\r\n\tIn conclusion, this book is intended for Engineers for research in the domains of speech signals and ECG denoising and also in the domain of image denoising. Many mathematical tools can be used for speech enhancement, ECG Denoising, and Image Denoising. Among those tools, we can mention wavelets, Empirical Mode Decomposition, Total Variation Denoising, Non-Local Means (NLMS), Kalman Filtering, Wiener Filtering, Deep Learning, etc.
",isbn:"978-1-83768-030-6",printIsbn:"978-1-83768-029-0",pdfIsbn:"978-1-83768-031-3",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,isNomenclature:!1,hash:"9885534183ae520bcc63a91d4d083390",bookSignature:"Dr. Mourad Talbi",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11943.jpg",keywords:"Speech Enhancement, Thresholding, Signal to Noise Ratio, Wavelets, ECG Denoising, Empirical Mode Decomposition, Total Variation Denoising, Image Denoising, SNR, Non-local Means (NLMS), Kalman Filtering, Wiener Filtering",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"May 11th 2022",dateEndSecondStepPublish:"July 12th 2022",dateEndThirdStepPublish:"September 10th 2022",dateEndFourthStepPublish:"November 29th 2022",dateEndFifthStepPublish:"January 28th 2023",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"7 days",secondStepPassed:!1,areRegistrationsClosed:!1,currentStepOfPublishingProcess:2,editedByType:null,kuFlag:!1,biosketch:"Assistant Professor Mourad Talbi obtained his Ph.D. in Electronics at the Faculty of Sciences of Tunis, Tunisia. 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\n
1. Introduction
\n
Macroscopic analysis refers to the method of observation, description, and analysis of the macroscopic features, such as shape, morphology, dimensional accuracy, cracks, processing defects, fracture surface, etc., of materials by the naked eye or using a magnifier at a low magnification (usually less than 50 times magnifying) [1, 2, 3]. Due to its simplicity and convenience, macroscopic analysis is widely used in the production and engineering practice. However, in recent years, with the development of the material characterization techniques and equipment, more and more engineers and technicians are inclined to rely on the advanced characterization equipment in the actual analysis and testing process, thus ignoring various macroscopic analysis methods. Particularly in the failure analysis of actual working parts, if due attention failed to be paid to macroanalysis, some wrong judgments can be easily made, which will eventually lead to the catastrophic consequences [4, 5].
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In the process of failure analysis, macroanalysis is usually the first and the most important step. Through the macroanalysis, the failure mode, such as wear, corrosion, severe plastic deformation or fracture, etc., can be determined rapidly. In addition, the specific location of the failing point in the entire component can be determined by macroanalysis, such as whether the failed position bear the maximum force, whether the stress is concentrated at specific locations, and whether a processing defect exists near the fracture surface, etc. These judgments are helpful to find the specific cause of the failure.
\n
The application of macroscopic analysis in metal materials mainly consists of etching, imprinting, nondestructive testing, and fracture surface observation methods [6]. Among them, the etching and imprinting methods are mainly used for detecting metallurgical defects such as microstructural segregation, inclusion, looseness, and pores in metal parts and are also used for cleaning the fracture surface of the failed samples [7, 8]. However, with the continuous improvement of manufacturing processes and technologies in recent years, the metallurgical defects in metal parts have been greatly reduced, and the failure of metal parts is rarely caused by metallurgical defects. Therefore, the application of etching and imprinting methods in failure analysis became fewer. Comparing to the etching and imprinting methods, nondestructive testing technique is an important means for detecting the sample surface and subsurface or internal defects without spoiling the metal parts. It is often used for testing sample quality and assisting the failure analysis process [9, 10, 11].
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In the actual failure cases, fracture failure is the most important failure mode of mechanical parts. Therefore, the fracture surface observation method plays an important role in the failure analysis and is one of the most important and commonly used methods in the failure analysis process [12]. The stress condition and the failure process can be judged through observing the position of the fracture surface. By observing the characteristics of the fracture surface, the position of the crack source can be accurately determined [13], which provides an important basis for further analysis of the causes of subsequent fractures.
\n
Railway fasteners, used for connecting the rails with the roadbed and playing a role of shock absorption, are important working parts in the railway transportation [14, 15, 16]. It will seriously affect the safety of the train if the fracture occurs. Based on the railway fastener cases failed in different ways, this chapter reveals the causes of the fracture from the perspective of macroanalysis and discusses the position and role of macroanalysis in the failure analysis.
\n
\n
\n
2. Macroanalysis of the railway fastener fracture cases
\n
\n
2.1 The premature fatigue failure of fasteners caused by processing defects
\n
\n\nFigure 1\n shows the fracture condition of a rail fastening clip after the fatigue test of 4 × 105 cycles. However, according to the TB/T2329-2002 Chinese standard for the fatigue tests of rail fasteners, the samples should not fracture after 5 × 106 cycles. In order to find out the reasons of the premature failure, macroscopic analysis was conducted on the failed sample. As shown in \nFigure 1a\n, the fracture surface is not located in the position bearing the maximum stress during fatigue tests. The detailed observation reveals that a processing defect exists near the crack initiation region, as is shown in \nFigure 1b\n. This defect is mainly caused by the excessive extrusion of the hot plastic mold during induction heating, resulting in a local stress concentration at the defect. Subsequent quenching further increased the local stress at defects. During the fatigue tests, crack initiated from the stress concentrated position at the defects leading to the premature failure of the tested sample. As shown in \nFigure 1c\n, the characteristics of the fracture surface were revealed by the macroscopic analysis. The fracture surface shows the feature of a typical fatigue failure mode. The crack initiation region, crack expansion zone, and the final fracture region can be clearly observed on the fracture surface as marked in \nFigure 1c\n. Since the crack expansion zone occupies a large area, it indicates that, after the cracks initiated at the surface defect, the sample undergoes a crack expansion period under the cyclic load before the final fracture. According to the theoretical equation reported in the literature [17, 18], the fracture strength of the tested rail fastening clip can be calculated based on the area of the instantaneous fracture zone and the maximum load applied.
\n
Figure 1.
Macroscopic analysis of the premature fatigue fractured rail fastening clip caused by surface processing defects: (a) the overall morphology of the fractured clip, (b) the processing defects near the crack initiation region, and (c) the morphology of the fractured surface.
\n
In addition to the macroscopic analysis of the failed sample itself, analysis of the manufacturing environment, production conditions, and the service environment of the samples is also required. Sometimes, the external environments and service conditions can also play a key role on the sample failure. For example, oil was used as a common cooling medium in the heat treatment for many alloy steels. When the humidity in the heat treatment plant is high, the content of water in the quenching oil will increase continuously with the increasing of time. Therefore, the cooling rate will increase significantly when quenching is carried out in the oil with a certain concentration of water. When quenching alloy steels with a good hardenability, the internal stress will increase greatly due to the higher cooling rate, which leads to the increased risk of cracking after quenching of the sample [19].
\n
\n
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2.2 The premature failure caused by improper heat treatments
\n
Another example shows the effect of the producing process on the failure conditions of the rail fasteners. In order to improve production efficiency and reduce cost, the rail fasteners are subjected to medium frequency induction heating treatment before being deformed into the “M” shape. Then, the railway fasteners were quenched by the residual heat of induction heating after the thermoforming. In order to further reduce costs and improve efficiency, a company replaced the original intermediate frequency induction heating with high frequency induction heating in the production of railway fasteners. Because the heat generated by the high-frequency induction heating is more concentrated on the sample surface, it is easy to cause the uneven heating of the samples, resulting in large residual stress. In addition, the macroscopic factors such as insufficient heating time, insufficient heating power, or incorrect heating location of the sample may cause the inhomogeneity of the microstructure in the heat-treated samples. This type of microstructural inhomogeneity will lead to the property difference in certain regions, which can greatly reduce the fatigue life of the railway fasteners and cause the premature fatigue failure. \nFigure 2\n shows the fracture condition of railway fasteners, and the fatigue test is carried out after the high-frequency-inducing heating process. The premature failure occurred after 1.2 × 106 fatigue cycles (normally 5 × 106 cycles without fracture).
\n
Figure 2.
The macroscopic morphology of the premature fatigue fracture samples processed by the high-frequency-inducing heating.
\n
Compared with the case shown in \nFigure 1\n (case 1), the fracture position of the fastener is at the region bearing the maximum stress (as marked by the arrow in \nFigure 2a\n). The appearance of the failed region is normal, no obvious processing defect can be observed, and the fracture morphology also has typical fatigue fracture morphology including the crack initiation region, crack expansion zone, and the final fracture region [20, 21]. The area of the crack expansion region is comparable to that of case 1, but its fatigue life is much higher than the case 1, indicating that the fatigue crack growth rate is significantly lower than case 1. However, because the sample still did not reach the fatigue life of the typical fastener, it belongs to the abnormal fracture type. Different from case 1, the reason of the premature failure of case 2 cannot be directly found from the macroscopic analysis, and the microscopic analysis is therefore required. Since the fastener was produced by high-frequency heating rather than the original intermediate frequency heating, it is suspected that the uneven distribution of microstructure caused the premature fatigue fracture. Therefore, the metallographic microstructure analysis was carried out on the normal and the prematurely failed fastener at the position bearing the maximum stress during fatigue test. The position for extracting the sample parts and the corresponding microstructure are shown in \nFigure 3\n.
\n
Figure 3.
The sample extraction position of normal (a) and prematurely failed railway (b) fasteners. (b, c) and (e, f) are the corresponding metallographic microstructure of the normal and prematurely failed fasteners, respectively.
\n
As shown in \nFigure 3a\n and \nb\n, the samples for microstructure observation of the normal and prematurely failed fasteners were cut from the same position near the fracture surface. The samples were ground by SiC paper and polished. The Nital solution (4% alcohol solution of nitric acid) was used as the etching solution. An optical microscope was used to complete the microstructure observation of the samples, and the results are shown in \nFigure 3c\n–\nf\n. \nFigure 3c\n and \nd\n shows the microstructure of the normal railway fastener after quenching and tempering in the medium temperature range; the typical tempered troostite and a small amount of ferrite can be clearly observed. The troostite and ferrite grains are fine, and they distributed evenly in the microstructure. \nFigure 3e\n and \nf\n shows the microstructure of the prematurely fractured samples. The obvious microstructure segregation can be observed from \nFigure 3e\n, which is caused by the large amount of dissolved cementite due to the fast heating rate of the high-frequency-inducing heating. The cementite came from the pearlite before heat treatment. As can be seen from \nFigure 3f\n, the grains are coarser, and in addition to the undissolved cementite, large block-shaped ferrite can also be observed. This is mainly due to the high heating rate and high temperature caused by the high-frequency-inducing heating. The rapid heating speed leads to the existence of a large amount of undissolved cementite. The heating temperature is too high, resulting in the formation of coarse microstructures [22]. This microstructural inhomogeneity can seriously affect the fatigue performance of the samples. Cracks are more prone to initiate at the microstructure with poor mechanical properties under the applied cyclic load, resulting in the premature fatigue fracture. This example shows that in the process of failure analysis, in addition to the analysis of the macroscopic characteristics of the sample, the macroscopic factors such as the production environment and the service environment of the sample parts are also important and sometimes are important causes of sample failure. It is sometimes difficult to directly and accurately determine the cause of failure from macroanalysis. This requires a combination of macroanalysis and microanalysis to achieve the accurate failure analysis results.
\n
\n
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2.3 The effect of the service condition on the failure of railway fasteners
\n
In addition to the manufacturing processes, the service environment is sometimes critical to the macroanalysis of failures. For example, in the following case, an e-type fastener widely used in the subway track has a premature fatigue fracture when it has been used in practice for about 1 year (the designed service life is 10 years). This kind of fastener breakage will cause major safety hazards to the safe operation of the train. It is necessary to analyze the causes of the failure in order to eliminate potential dangers in time and ensure the safe operation of the train. In order to analyze the cause of the fracture, a macroscopic observation of the broken subway track fastener clip was first carried out; the results are shown in \nFigure 4\n.
\n
Figure 4.
The macroscopic morphology and surface wear scars of the fractured metro fastener: (a) the macroscopic morphology of the failed fastener showing the position of the fracture surface and the wear marks, (b) the obvious wear scar that can be observed on the surface of the straight section of the fastener clip, and (c) the enlarged view of wear scar.
\n
As can be seen from \nFigure 4a\n, the breaking position located at the root of the straight section of the fastener, and this straight section is installed in the fixed slot. The fracture happened at the boundary between the straight section and the residual curved part, in which the maximum stress is loaded in the broken position in the actual working condition. A detailed observation of the sample surface reveals obvious wear marks. Moreover, the wear marks are in the same direction along the transverse arc of the fastener sample (see \nFigure 4b\n). As can be observed from the magnified view shown in \nFigure 4c\n, the wear marks have a certain depth, and their propagation direction is consistent. Based on the direction and depth of the wear scar, it can be preliminarily concluded that the wear scars on the surface of the straight section of the railway fastener were caused by the relative rotation with the spring clip slot it contacted with. However, in the normal circumstances, this type of rotation is not allowed, because the rotation will reduce the pressure between the fastener and the railway track, affecting the train safety. Combined with the relatively deep wear marks, the broken fastener is subjected to a large external force before failure. The reason causing this large external force can only be determined by the on-site investigation with the understanding of the service situation.
\n
According to the investigation of the service scene, the subway operates along a circle line, and the fasteners with premature fatigue failure occurred mostly at or near the curve region of the railway track. This indicates that in addition to the force of caused by the vibration of the track when a train passed, the spring bar is also subjected to the centrifugal force when the train is adjusting directions. Under the combined force of the vibration and the centrifugal force, the fastener rotated relatively in the slot, resulting in a surface with a consistent direction of wear scar. After multiple friction, the wear marks at the position where the fastener is in contact with the edge of the slot became deeper and deeper, and thus fatigue cracks were generated. Due to the large external force, the crack spreads rapidly, resulting in the final premature fracture failure of the fastener. In order to more accurately determine the cause of the failure of the elastic strip, combined with the macroscopic analysis of the fracture surface, the metallographic microstructures near the fracture surface were further observed and analyzed. The results are presented in \nFigure 5\n.
\n
Figure 5.
The macroscopic morphology of the fracture surface and the microstructure of the samples near the fracture surface: (a) the fracture surface morphology, (b) the cross-sectional microstructure of the sample near the fracture surface, and (c) the microstructure of core region of the sample near the fracture surface.
\n
From the macroscopic analysis of the fracture surface as shown in \nFigure 5a\n, the crack initiation region has a certain area, and the color is dark blue and slightly black, which is mainly due to the inconsistent deformation of the elastic strips on both sides of the crack, and the oxidation of the fracture surface resulted from the temperature rising caused by the relative extrusion and friction. This again proves that the elastic strips underwent severe torsional deformation during actual service. From the morphology of the crack extension area in \nFigure 5a\n, the extended area has obvious macroscopic fan-shaped stripes, and the spacing between the strips is large. The spacing between the fan-shaped stripes is large, which indicates that under the load of the torsion force, the severe wear scars were first produced on the surface where the stress reaches the maximum value. Then, micro-cracks were formed in the most severely worn areas. Under the combined load caused by the vibration of the rail tracks and the centrifugal force, the cracks expanded rapidly, resulting in the final premature fracture. At the same time, samples near the fracture surface were extracted for the preparation of the metallographic sample. The surface and center microstructure of the surface of the prepared samples is shown in \nFigure 5b\n and \nc\n. It can be observed that the tempered troostite (or tempered torsite) and a small amount of ferrite are the main microstructure of the elastic stripe after quenching with medium temperature tempering, which is the normal microstructure. A layer of anticorrosion treatment can be observed on the surface, which is a conventional treatment for railway fasteners.
\n
The early failure of the railway fasteners caused by the external service environment indicates that in addition to considering the material selection and processing technology and performance of the product, the actual working environments should also be taken into consideration. In order to ensure the operation safety of the equipment, the design and manufacture of the product can be improved based on the actual working condition of the components. Only then can the safety factor in the actual service process be increased.
\n
\n
\n
\n
3. The function of macroscopic analysis in the failure analysis of railway fastening clips
\n
Based on the above analyses of several failure cases of the railway fasteners, it can be concluded that the macroscopic analysis plays a key role in the process of failure analysis. Combined with the macroscopic characteristics of the sample, the failure site, the background data, the service environment, and other macro factors, the mode and cause of the failure can be preliminarily judged after careful observation and analysis. On the basis of macroanalysis, with the help of modern analytical test methods, microanalysis, and computer simulation techniques, the failure mechanism can be further explored to accurately determine the cause of failure. Moreover, the solutions can be given based on the causes of the failure for avoiding the occurrence of disasters.
\n
In Section 2.1, if the macroscopic analysis is not carried out, the processing defects near the crack source cannot be found, and the causes of the premature fracture of the fasteners will not be accurately determined, which will have a serious impact on the production and sales of the products. If the unqualified products with surface defects flow into the market, it will cause serious danger to the safety of the train operation. Moreover, as discussed in Section 2.2, combined with the macroscopic factors of the changes of production conditions (medium-frequency induction heating to high-frequency induction heating), it is preliminarily believed that the premature fatigue failure of the railway fastener is caused by the uneven heating. Then, under the guidance of the macroanalysis, the microscopic analysis is carried out, and the cause of the premature fatigue failure is finally determined. Based the failure analysis results, the manufacturers were told to make improvements in time to avoid major economic losses and safety hazards. Similarly, in the example of Section 2.3, the causes of the fastener premature fracture were determined by combining the macroscopic damage on the appearance of the failed fastener with the complex force during service, through the investigation of the on-site service environment. It provides an important basis for the further improvement of the performance of railway fasteners.
\n
All in all, macroanalysis is the first and most important step in failure analysis. Firstly, through macroanalysis, the position of the failure and the failure mode can be accurately determined, which lays a foundation for further analyzing the failure causes. Secondly, with the understanding of the failure location and the failure mode, the fracture reasons can be determined based on the force analysis, the service environment, and the manufacturing processes. Finally, combined with the verification experiments, microanalysis methods and computer simulation, the causes of the failure can be accurately determined, and solutions and suggestions can be given to eliminate potential safety hazards and avoid disasters.
\n
With the development of modern technology and manufacturing equipment, product defects caused by design, materials, and processing technology are becoming less and less, and accidents caused by the product failure are also declining year by year. However, the assembly of components, special service environment, sudden natural disasters, etc. will seriously affect the operational safety of various types of equipment and facilities, in which special attention should be paid in the failure analysis. In particular, in recent years, with the development of science and technology, a large number of high-performance new materials and products are widely used, which brings new challenges to failure analysis. It is also necessary to continuously develop and innovate failure analysis methods, means, and concepts and lay the foundation for adapting to accurate failure analysis in the new situation and environment.
\n
\n
Acknowledgments
\n
The authors gratefully acknowledge financial support from the Sichuan Education Reform Project (No. JG2018-158).
\n
\n',keywords:"failure analysis, macroscopic analysis, railway fastener, fracture, crack initiation",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/69147.pdf",chapterXML:"https://mts.intechopen.com/source/xml/69147.xml",downloadPdfUrl:"/chapter/pdf-download/69147",previewPdfUrl:"/chapter/pdf-preview/69147",totalDownloads:886,totalViews:0,totalCrossrefCites:0,totalDimensionsCites:0,totalAltmetricsMentions:0,impactScore:0,impactScorePercentile:33,impactScoreQuartile:2,hasAltmetrics:0,dateSubmitted:"March 29th 2019",dateReviewed:"August 20th 2019",datePrePublished:"September 20th 2019",datePublished:"May 6th 2020",dateFinished:"September 20th 2019",readingETA:"0",abstract:"Macroscopic analysis plays an important role in failure analysis, which cannot be replaced by other analyzing methods. In recent years, with the development of characterization techniques, more and more engineers and technicians rely on the advanced analytical testing methods in the process of failure analysis, ignoring the methods and means of macroscopic analysis. This can easily lead to some wrong judgments. Therefore, this chapter will combine with the cases to explain the position and role of macroanalysis in the failure analysis of rail fastening clips and to offer references for engineers and technicians in relevant fields.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/69147",risUrl:"/chapter/ris/69147",book:{id:"9373",slug:"engineering-failure-analysis"},signatures:"Guodong Cui, Shuaijiang Yan, Chengsong Zhang, Dazhi Chen and Chuan Yang",authors:[{id:"300022",title:"Dr.",name:"Guodong",middleName:null,surname:"Cui",fullName:"Guodong Cui",slug:"guodong-cui",email:"gdcui@swjtu.edu.cn",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"302915",title:"Mr.",name:"Shuaijiang",middleName:null,surname:"Yan",fullName:"Shuaijiang Yan",slug:"shuaijiang-yan",email:"ysj@my.swjtu.edu.cn",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"Southwest Jiaotong University",institutionURL:null,country:{name:"China"}}},{id:"302917",title:"Dr.",name:"Chengsong",middleName:null,surname:"Zhang",fullName:"Chengsong Zhang",slug:"chengsong-zhang",email:"cszhang@home.swjtu.edu.cn",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"Southwest Jiaotong University",institutionURL:null,country:{name:"China"}}},{id:"302919",title:"Prof.",name:"Chuan",middleName:null,surname:"Yang",fullName:"Chuan Yang",slug:"chuan-yang",email:"chyang@home.swjtu.edu.cn",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"Southwest Jiaotong University",institutionURL:null,country:{name:"China"}}},{id:"309194",title:"Dr.",name:"Dazhi",middleName:null,surname:"Chen",fullName:"Dazhi Chen",slug:"dazhi-chen",email:"cdz@swjtu.edu.cn",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"Southwest Jiaotong University",institutionURL:null,country:{name:"China"}}}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Macroanalysis of the railway fastener fracture cases",level:"1"},{id:"sec_2_2",title:"2.1 The premature fatigue failure of fasteners caused by processing defects",level:"2"},{id:"sec_3_2",title:"2.2 The premature failure caused by improper heat treatments",level:"2"},{id:"sec_4_2",title:"2.3 The effect of the service condition on the failure of railway fasteners",level:"2"},{id:"sec_6",title:"3. The function of macroscopic analysis in the failure analysis of railway fastening clips",level:"1"},{id:"sec_7",title:"Acknowledgments",level:"1"}],chapterReferences:[{id:"B1",body:'\nZhang T, Bao R, Fei B. Load effects on macroscopic scale fatigue crack growth path in 2324-T39 aluminium alloy thin plates. International Journal of Fatigue. 2014;58:193-201. DOI: 10.1016/j.ijfatigue.2013.04.014\n'},{id:"B2",body:'\nTang XS, Wei TT. Microscopic inhomogeneity coupled with macroscopic homogeneity: A localized zone of energy density for fatigue crack growth. International Journal of Fatigue. 2015;70:270-277. DOI: 10.1016/j.ijfatigue.2014.10.003\n'},{id:"B3",body:'\nGarcía-Martínez M, García de Blas Villanueva FJ, Valles González MP, Pastor Muro A. Failure analysis of the rod-end bearing of an actuating cylinder. Engineering Failure Analysis. 2019;104:292-299. DOI: 10.1016/j.engfailanal.2019.06.006\n'},{id:"B4",body:'\nVukelic G, Brcic M. Failure analysis of a motor vehicle coil spring. Procedia Structural Integrity. 2016;2:2944-2950. DOI: 10.1016/j.prostr.2016.06.368\n'},{id:"B5",body:'\nGuo R, Xue S, Zheng L, Deng A, Liu L. Fracture failure analysis of DY08 aluminum alloy elastic coupling. Engineering Failure Analysis. 2019;104:1030-1039. DOI: 10.1016/j.engfailanal.2019.06.074\n'},{id:"B6",body:'\nVander Voort GF. Metallography and failure analysis. Materials Characterization. 1994;33:193. DOI: 10.1016/1044-5803(94)90044-2\n'},{id:"B7",body:'\nXu J, Sun Y, Liu B, Zhu M, Yao X, Yan Y, et al. Experimental and macroscopic investigation of dynamic crack patterns in PVB laminated glass sheets subject to light-weight impact. Engineering Failure Analysis. 2011;18:1605-1612. DOI: 10.1016/j.engfailanal.2011.05.004\n'},{id:"B8",body:'\nYou JH. Triple-scale failure estimation for a composite-reinforced structure based on integrated modeling approaches. Part 2: Meso- and macroscopic scale analysis. Engineering Fracture Mechanics. 2009;76:1437-1449. DOI: 10.1016/j.engfracmech.2008.10.017\n'},{id:"B9",body:'\nDwivedi SK, Vishwakarma M, Soni PA. Advances and researches on non destructive testing: A review. Materials Today: Proceedings. 2018;5:3690-3698. DOI: 10.1016/j.matpr.2017.11.620\n'},{id:"B10",body:'\nBrown M, Wright D, M’Saoubi R, McGourlay J, Wallis M, Mantle A, et al. Destructive and non-destructive testing methods for characterization and detection of machining-induced white layer: A review paper. CIRP Journal of Manufacturing Science and Technology. 2018;23:39-53. DOI: 10.1016/j.cirpj.2018.10.001\n'},{id:"B11",body:'\nStarke P, Wu H. Use of non-destructive testing methods in a new one-specimen test strategy for the estimation of fatigue data. International Journal of Fatigue. 2018;111:177-185. DOI: 10.1016/j.ijfatigue.2018.02.011\n'},{id:"B12",body:'\nKobayashi T, Shockey DA. The relationship between fracture surface roughness and fatigue load parameters. International Journal of Fatigue. 2001;23:135-142. DOI: 10.1016/S0142-1123(01)00149-9\n'},{id:"B13",body:'\nPark CY, Grandt AF. Effect of load transfer on the cracking behavior at a countersunk fastener hole. International Journal of Fatigue. 2007;29:146-157. DOI: 10.1016/j.ijfatigue.2006.01.014\n'},{id:"B14",body:'\nLi L, Thompson D, Xie Y, Zhu Q , Luo Y, Lei Z. Influence of rail fastener stiffness on railway vehicle interior noise. Applied Acoustics. 2019;145:69-81. DOI: 10.1016/j.apacoust.2018.09.006\n'},{id:"B15",body:'\nWei X, Yang Z, Liu Y, Wei D, Jia L, Li Y. Railway track fastener defect detection based on image processing and deep learning techniques: A comparative study. Engineering Applications of Artificial Intelligence. 2019;80:66-81. DOI: 10.1016/j.engappai.2019.01.008\n'},{id:"B16",body:'\nCao Z, Brake MRW, Zhang D. The failure mechanisms of fasteners under multi-axial loading. Engineering Failure Analysis. 2019;105:708-726. DOI: 10.1016/j.engfailanal.2019.06.100\n'},{id:"B17",body:'\nZhang J, Song Q , Zhang N, Lu L, Zhang M, Cui G. Very high cycle fatigue property of high-strength austempered ductile iron at conventional and ultrasonic frequency loading. International Journal of Fatigue. 2015;70:235-240. DOI: 10.1016/j.ijfatigue.2014.09.021\n'},{id:"B18",body:'\nYu M, Wei C, Niu L, Li S, Yu Y. Calculation for tensile strength and fracture toughness of granite with three kinds of grain sizes using three-point-bending test. PLoS ONE. 2018;13:e0180880. DOI: 10.1371/journal.pone.0180880\n'},{id:"B19",body:'\nMa Z, Wang Y, Ji S, Xiong L. Fatigue properties of Ti-6Al-4V alloy friction stir welding joint obtained under rapid cooling condition. Journal of Manufacturing Processes. 2018;36:238-247. DOI: 10.1016/j.jmapro.2018.10.006\n'},{id:"B20",body:'\nBurcham MN, Escobar R, Yenusah CO, Stone TW, Berry GN, Schemmel AL, et al. Characterization and failure analysis of an automotive ball joint. Journal of Failure Analysis and Prevention. 2017;17:262-274. DOI: 10.1007/s11668-017-0240-4\n'},{id:"B21",body:'\nRobin MC, Delagnes D, Logé R, Bouchard PO, Da Costa S, Monteagudo-Galindo M, et al. Thermo-mechanical fatigue behaviour of welded tubular parts made of ferritic stainless steel. International Journal of Fatigue. 2013;54:84-98. DOI: 10.1016/j.ijfatigue.2013.04.004\n'},{id:"B22",body:'\nXu L, Chen L, Sun W. Effects of soaking and tempering temperature on microstructure and mechanical properties of 65Si2MnWE spring steel. Vacuum. 2018;154:322-332. DOI: 10.1016/j.vacuum.2018.05.029\n'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Guodong Cui",address:"gdcui@swjtu.edu.cn",affiliation:'
School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, China
School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, China
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1. Introduction
The human body exists in close relation with numerous structurally and functionally diverse microbes inhabiting different parts of the body. The mouth, the gastrointestinal tract (GIT), and the vagina are most heavily populated. This composition is known as microbiota which is acquired soon after birth [1]. The microbiota that is exclusively found in GIT is referred to as ‘Gut microbiota.’ Gut microbiota is primarily non-pathogenic and plays a vital role in conferring health benefits to the host [2]. Through metabolic activities and physiological regulation such as resistance to pathogens, improvement of intestinal barrier function, promotion of nutrient absorption, formation of bioactive compounds [2]. It may also influence the physiology, biochemistry of the host [3].
The idea that bacteria can confer health benefits to humans was postulated 100 years ago by Elie Metchnikoff. The ‘probiotic’ word is derived from the Greek word, meaning “for life” and has had several different meanings over the years [4]. The increase in evidence of the benefits of probiotics and prebiotics, especially in health improvement, led to its applications in various food industries. This book chapter highlights the significance of gut microbiota and the emergence of probiotic concepts to benefit human health. In this chapter, we have made a little attempt to introduce the concept of probiotics and prebiotics, their benefits to humans’ health, and their probability of being applicable in various fields.
2. Gut microbiota
The human body harbors a complex ecosystem that includes more than 1000 various microorganisms [5, 6]. It means the number of bacteria within the gut is about ten times that of eukaryotic cells in the human body. In a healthy animal, the internal tissues such as blood, brain, muscle, etc. in a healthy animal are usually free of microorganisms. However, the surface tissues, such as skin and mucous membranes, are constantly in contact with environmental organisms and become readily colonized by various microbial species. The microbiota extends from mouth to anus and into the vaginal tract of women. In the healthy host, enteric bacteria colonize the alimentary tract soon after birth, and the composition of the intestinal microbiota remains relatively constant [7]. The normal flora of humans consists of a few eukaryotic fungi and protists, but bacteria are the most numerous and obvious microbial components of the normal flora. The total genomic content of microbiota is referred to as a microbiome that inhabits a specific anatomical site of the body [8]. The mixture of organisms regularly found at any anatomical site is referred to as the “normal flora”. However, researchers in the field who prefer the term “indigenous microbiota,” which includes resident microbiota, transient microbiota, and opportunistic microbiota.
The gut microbiome exhibits various interactions with the human body. It may be mutualistic or pathogenic. The interactions between the gut microbiome and host have evolved into symbiotic relations. It confers various benefits to the human body, significantly strengthens the host’s immune system, and protects against various diseases caused by harmful pathogens. Hence, it is helpful to study the symbiotic relationship of the gut microbiome with the host and its influence on the host’s overall health.
2.1 Composition of gut microbiota
The gut microbiota is composed of four main phyla: Firmicutes, Bacteroidetes, Actinobacteria, and Proteobacteria. Predominantly, anaerobic bacteria colonize the Gastrointestinal tract (GIT) [9].
GI tract consists of the stomach, small intestine, and large intestine. Various parts of the GI tract differ in their environmental characteristics, chemical compositions, and physiological properties. Therefore types and numbers of microbiota vary in different parts. In general, microorganisms increase in numbers from the stomach to the small intestine to the large intestine.
2.1.1 Microbiota of stomach
The microbes in the stomach are primarily of similar types that are present in the mouth and throat. Generally, aerobic microbes inhabit the stomach, and that too in a lesser amount than the population of mouth and stomach. The stomach receives many microbes from the mouth through food and water, but most of them are killed due to hydrochloric acid (HCl). Thus, few microorganisms that can tolerate high pH can form normal resident flora of the stomach.
Organisms generally found in the stomach are – Lactobacillus, Enterococcus, Streptococcus, Staphylococcus, Peptostreptococcus, Candida, Helicobacter pylori, etc. [10, 11]. Some of them are hazardous to health, such as Helicobacter pylori, which can cause chronic gastritis and peptic ulcers.
2.1.2 Microbiota of small intestine
The small intestine is a tube about 6 meters long-running from the stomach to the large intestine. The small intestine usually has three sections: duodenum, jejunum, and ileum. Each section reflects slightly different functions. The microbiota of the small bowel is the least well understood due to its inaccessibility for study.
Duodenum is adjacent to the stomach, and it is slightly acidic. The duodenum includes similar types of organisms that are found in the stomach. It mainly acquires acid-resistant organisms such as Lactobacillus and Enterococcus. The intestine becomes less acidic from the duodenum to the ileum; hence, the microbial population increases. In the jejunum, prominently, lactobacillus, Enterococci, Candida albicans, etc., are found. In ileum microbial population resembles that of the large intestine. It mainly includes obligate anaerobes such as Clostridium perfringes, anaerobic E. coli., Bacilli, Streptococcaceae. Actinomycinaeae and Corynebacteriaceae are abundant in the duodenum, jejunum, or ileum [12, 13].
2.1.3 Microbiota of large intestine
The large intestine follows on from the small intestine. The large intestine receives remains of food that enzymes have not digested. The chyme, on entering the large intestine, is referred to as feces. The large intestine is divided into three distinct parts: caecum, colon, and rectum. About 1100 different species of microbes are present in the large intestine [14].
The large intestine harbors obligate anaerobes and facultative anaerobes. The more common genera include Bacteroides, Clostridium, Eubacterium, Roseburia, Faecalibacterium, and Ruminococcus [15, 16]. The large bowel includes increased Lachnospiraceae (Firmicutes) proportions, and Bacteroidetes are found in the colon [13]. It also inhibits E.coli, Lactobacillus, Bifidobacterium, Enterococcus in smaller numbers.
2.2 Benefits of gut microbiota
Earlier, the gut microbiota was thought to be commensals whose only benefit was controlling the abundance of pathogenic bacteria. However, as the knowledge about these symbionts increased, their essential roles, such as aiding digestion and various metabolites, were also known to improve the immune system [17, 18]. The gut microbiota plays a crucial role in immunomodulation and the nervous system and intestinal mucosal system development. In addition, gut microbiota plays a crucial role in synthesizing essential vitamins such as vitamin B12, vitamin K, nicotinic acid, pyridoxine, thiamine [19]. The gut microbiota generates short-chain fatty acids (SCFAs) by fermenting complex carbohydrates. These SCFAs play a significant role in inflammatory response and regulation of immune response. The gut microbiota also influences epithelial homeostasis [19].
There are pieces of evidence that gut microbiota provides extra nutrition. It could be due to the digestion by enzymes of the resident microbiota. Another benefit of gut microbiota is a defense against a range of pathogens, including Listeria cytogenes, Clostridium botulinum, and Cryptosporidium parvum. The gut microbiota provides a hostile environment, produces antimicrobial substances, and strengthens the human body’s defenses to defend against pathogens. It also stimulates peristalsis, so gut contents are moved more quickly, making it more difficult for newly-arrived pathogens to be established.
2.3 Disturbance of gut microbiota
The composition of gut microbiota may vary between individuals though some key bacterial species are typically present in most. Diet is thought to explain over 50% of these microbial structural variations in mice and 20% in humans, signaling the potential for dietary strategies in disease management through gut microbiota modulation [20]. The gut microbiota shows drastic changes in infants with lactation followed by an introduction to solid food. The mode of intake, medication dosage may influence the gut microbiota. Gut microbes are regularly purged and have the ability to double in specific time intervals. The short-term and long-term dietary changes and modification in micronutrient intake can significantly change gut microbiota composition. The experiment conducted by Wu et al. showed a dramatic shift in the fecal microbiota of the participants due to high fat/low fiber and low fat/high fiber. Fiber content and type were thought to be primer determinants of the composition of the microbiota of the gut.
Through antibiotics, improvement in human health is achieved through the drugs have negative consequences also. Antibiotic drugs control the infections caused by pathogens, but other beneficial bacteria are also harmed. A disturbed microbiota may not function well against infections caused by new pathogens, resulting in the overgrowth of pathogens such as Clostridium difficile [21]. Several factors may influence the disturbance of gut microbiota caused by antibiotics: (i) the dose and duration of the drug (ii) the range of microbes affected by antibiotics (e.g., broad-spectrum or narrow-spectrum) (iii) the proportion of antibiotic that is being absorbed into the body or resides in the intestine.
Most antibiotics are taken orally, and some are given intravenously. The latter type has a significant influence to disturb microbiota. Different antibiotics have different effects, e.g., penicillin has minor effects on the gut microbiota, while ampicillin causes significant disturbance to the gut microbiota. Thus, there is a need to develop an alternative that is safer and effective for use. Increasing knowledge of probiotics and their efficacy against pathogens can aid the recovery of gut microbiota. Probiotics may be suitable to take after or simultaneously as antibiotics to reduce the risk of disease from disturbance of microbiota.
3. Probiotics
Probiotics are live organisms which when administered in an adequate amount, confers health benefits to the host (FAO and WHO, 2002). The characteristics of effective probiotics are their ability to survive the passage through the digestive tract and utilize the nutrients and substrates in a normal diet. Probiotics are healthy gut flora and thereby improve digestion. Several criteria have been used to prove any strain as novel probiotic strains, categorized into two groups: safety and functionality. The concept of probiotics deals with the constant introduction of the new microbes beneficial to the human host as an attempt to change the indigenous microbial population equilibrium to increase overall health [22].
3.1 History of Probiotics
The concept of using microbes to improve health is a hundred years old. During the twentieth century, probiotics gained much interest due to an increase in scientific evidence proving the beneficial effects of probiotics. The idea that bacteria could benefit human health was postulated almost 100 years ago by Elie Metchnikoff while working at the Pasteur Institute in Paris. Metchnikoff’s adoption of an idea to use beneficial bacteria to improve the bacterial population of the intestine arose from his inquiries into how old age could be delayed and life prolonged. Metchnikoff concluded that fermented milk drank by peasants of Bulgaria has a key role (Metchnikoff 1907) [21] in their longevity. He found a bacterium from peasant’s milk and named it Bacillus bulgaricus. He explained that the production of lactic acid by a bacterium reduces the harmful effects of other microorganisms. It is not sure which bacterium was found by Metchnikoff. It may be Lactobacillus bulgaricus, a strain that is commonly used in yogurt.
The term probiotic literally means ‘for life is derived from the Greek language. Lilly and Stillwell first coined this term in 1965 to describe “substances secreted by one microorganism which stimulates the growth of another” and thus was contrasted with the term antibiotic [23]. Parker modified this definition to “organisms which contribute to intestinal microbial balance” [24]. The concept of probiotics became weak after the early death of Metchnikoff and the development of antibiotic drugs. Though, interest in the general public did not fall entirely. One of the factors that gained the popularity of probiotics towards the end of the century is the rise of resistant strains of pathogens against different antibiotics.
3.2 Mechanism and action of probiotics
The mechanisms of probiotic action are diverse. The activities of these strains can influence other factors such as the presence of other bacteria in the intestinal environment or even the disease setting in which the strain is being used [25]. The characteristics of effective probiotics are their ability to survive the passage through the digestive tract and utilize the nutrients and substrates in a normal diet. However, some mechanisms have been reported for most of the probiotic strains, which include: colonization resistance, antimicrobial activity, antimutagenic effects, antigenotoxic effects, influence on enzyme activity, etc.
The probiotic bacteria have antagonistic effects on different microorganisms and competitive adherence to mucosa and epithelium. These characteristics also work as antimicrobial activity. By decreasing luminal pH, they are inhibiting other bacterial adherence, translocation, and secretion of antimicrobial substances such as antimicrobial peptides (e.g., bacteriocin), organic acids (lactic and acetic acid), hydrogen peroxide (in environments in which oxygen is present), diacetyl, β-hydroxypropionaldehyde [26, 27, 28, 29, 30]. The probiotics are also capable to modulate cell proliferation and apoptosis. Polysaccharide fermentation by probiotic strains increases the availability of short-chain fatty acids (SCFAs), which felicitate repair of epithelial damage. Some strains also produce mucus excessively, which enhances the intestinal barrier. It can separate bacteria from the lumen and prevent the colonization of the epithelium [31]. Probiotics can exert control over epithelial cells, dendritic cells, monocytes, macrophages, lymphocytes, IgA through different mechanisms for the stimulation of the human immune system; increased IgA decreases the number of pathogens, thus improving gut health [32, 33]. Figure 1 shows various mechanisms by which probiotics benefits health of host.
Figure 1.
Mechanism of probiotics.
3.3 Types of probiotic microbes
There is a growing number of microorganisms described as probiotics. Among the various types of microbes, bacteria are used as probiotics mainly. The potential of intestinal and dairy species Lactobacilli and Bifidobacteria as probiotics was postulated over a hundred years ago. At that time, the yearning to understand the microbial ecology of these groups in the human intestine was linked to the aspiration to manage and maintain human health. The link between Lactobacilli and human health was first proposed in the late 1800s by Metchnikoff [34].
The majority of the different species included in probiotics belong to the genus Lactobacillus. Metchnikoff favored this bacterium. They are normal flora of the small bowel as there is a wide range of food in that part of the small intestine. There are fewer lactobacilli present in the large bowel also. Lactobacilli are easy to grow, which aid as an essential factor in using probiotics at a commercial scale. Other characteristics of lactobacilli are resistance to gastric stress and the ability to grow in a microaerophilic environment that makes them well-suited to live in the gastrointestinal tract. Lactobacilli are heterofermentative and require many micronutrients to grow. The species most commonly used in probiotics are L. acidophilus, L. casei, L. crispatus, L. johnsonii, L. plantarum, L. reuteri, L. rhamnosus, L. salivarius. The probiotic effect of lactobacilli is as follow:
Secretion of lactic acid lowers the pH of GIT and eliminates harmful bacteria. Some lactobacilli produce acetic acid, which gives a more substantial effect than lactic acid against pathogens.
Lactobacilli produce antibiotic-like compounds referred to as bacteriocins, which restrict the growth of pathogens. Some of them also produce hydrogen, which exerts antibacterial effects.
Lactobacilli tend to attach to mucosa and form colonies, which is the primary requirement of good probiotics. They block the attachment of pathogens and may also influence the immune cells in the gut wall. Some lactobacilli also produce mucus in excess to discourage attachment of pathogens.
There are other genera of lactic acid-secreting bacteria. One of them is Enterococcus, which has species such as E. faecium that are used as probiotics. The mechanism is similar to those of lactobacilli.
Bifidobacteria are the second most commonly used type of bacteria in probiotic products. One of the reasons for their less popularity could be their incapability to grow and process commercially. Henry Tissier identified the unusually shaped Bifidobacterium from the stool of the baby. A large number of these bacteria in the intestine of the baby reassured that they are probably beneficial. Bifidobacteria reduce lactose intolerance, cholesterol levels, improve the gut immune system, and prevent gut infection in infants. Some of the species frequently used in probiotics are Bif. adolescentis, Bif. animals, Bif. bifidium, Bif. breve, Bif. longum, and Bif. infantis.
Like lactobacilli and bifidobacteria, other organisms such as E. coli, Bacillus subtilis, Saccharomyces cerevisiae, S. boulardii. Most E. coli are benign commensals, but some are opportunistic pathogens. E. coli Nissle 1971 (EcN) is the best known E. coli probiotic [35, 36]. Nissle bacteria are protected from stomach acid by added enteric coating. The coating won’t dissolve until it reaches the ileum and caecum. EcN strengthens the barrier function of epithelial cells against pathogens. EcN has been used as an anti-diarrhoeal and to treat constipation and ulcerative colitis [21]. Bacillus subtilis is a spore-forming bacterium; the spores protect the cells from gastric acid. Some of the spores germinate in the intestine and influence the gut immune system and stimulate lactobacilli’s growth. Some other Bacillus species are used as probiotics, such as B. coagulance, B. licheniformis, B. pumilus, and B. clausii. Saccharomyces boulardii, a sub-species of S. cerevisiae is used as probiotics. S. boulardiiis not normal flora of the gut, but it can live there temporarily and gives anti-diarrhoeal effects. Some probiotic organisms with Generally Regarded As Safe (GRAS) status are listed in Table 1.
Probiotic Lactic acid bacteria
Lactobacillus spp.
Bifidobacterium spp.
Lactobacillus rhamnosus
Bifidobacterium lactis
Lactobacillus plantarum
Bifidobacterium bifidum
Lactobacillusreuteri
Bifidobacterium animalis
Lactobacillus acidophilus
Bifidobacterium breve
Lactobacillus casei
Bifidobacterium infantis
Bifidobacterium longum
Other lactic acid bacteria
Non-lactic acid bacteria and yeast
Lactococcus lactis
Propionibacterium freudenreichii
Streptococcus thermophilus
Saccharomyces cerevisiae
Table 1.
List of probiotic microorganisms [21, 37, 38, 39].
4. Benefits of probiotics
There are certain diseases related to the disturbance of microbiota of the gastrointestinal tract. Some of them are infectious diarrhea, irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), lactose intolerance, antibiotic-associated diarrhea, constipation, gastritis, and stomach ulcers. There are evidences available showing influence of probiotics to treat such diseases. Other body parts may benefit from probiotics as microbiota is present in other body parts, not just the intestine. Furthermore, the immune system is connected to all parts of the body, so by influencing one part of the immune system, probiotics may influence others.
4.1 Effect of probiotics on diarrhea
Infectious diarrhea, traveler’s diarrhea (TD), antibiotic-associated diarrhea are various types of diarrhea caused by different conditions. Infectious diarrhea is generally caused by pathogenic microbes such as viruses, bacteria, yeast, or protozoan. Generally, normal bowel movements return after about three days, but they may not in children with acute diarrhea. In infants, rotavirus is the most common microbe responsible for diarrhea. Probiotics have been tried in many clinical studies as a supplement for rehydration therapy to treat infectious diarrhea in infants. The results have been positive and consistent [40]. In young children, the probiotics were also found to be effective in preventing the development of infectious diarrhea. The types of probiotic microbes used are lactobacilli, bifidobacteria, S. boulardii (yeast).
The traveler’s diarrhea may be caused by the water supply being contaminated with fecal matter, contaminated food. In the case of traveler’s diarrhea, the use of probiotics is more likely to be considered by adults. Though, the use of probiotics in TD has given a mixed response as the cause of TD differs depending on the local situation [41].
The use of antibiotics has revolutionized the treatment of bacterial infections. However, it promotes the rise of resistant bacteria and disturbs gut microbiota’s composition, which makes us vulnerable to pathogenic infection. Such infection of the intestine leads to diarrhea, referred to as ‘antibiotic-associated diarrhea (AAD)’. When the gut microbiota is disturbed, Clostridium difficile increases to infection level; this bacterium causes about one-fifth of AAD. In several studies, probiotic yeast S. boulardii was effective against C. difficile when given along with antibiotics [42]. In a number of cases, probiotic microbes such as LAB, S. boulardii, Clostridium butyricum prevented such diarrhea, although not all studies have shown probiotics to be effective [42, 43, 44, 45].
4.2 Effect of probiotics in Irritable Bowel Syndrome (IBS)
The irritable bowel syndrome is a common gastrointestinal disorder. In IBS an abnormal condition of gut contractions (motility) and increased gut sensations (visceral hypersensitivity) characterized by abdominal pain/discomfort, gas, bloating, mucous in stools, and irregular bowel habits with constipation or diarrhea. Several studies show the effect of probiotics on this disease; however, the mechanism by which probiotic organisms affect this condition is still unknown. A review and meta-analysis by Ford et al. concluded the beneficial effects of probiotics as a treatment on IBS symptoms, including RCTs published between 1939 and 2013, and it was emphasized that multi-strain probiotics had a more distinct effect on IBS symptoms [46, 47]. However, Lactobacillaceae and Bifidobacteriaceae (genus: Lactobacillus and Bifidobacterium) were the two most common families used in multi-strain probiotic supplements [47].
4.3 Effect of probiotics in inflammatory bowel disease (IBD)
Inflammatory bowel disease is a group of the chronic intestinal disease characterized by inflammation of the large or small intestine. Crohn’s disease (CD) and ulcerative colitis (UC) are the most common types of IBD. UC only affects the large bowel, and the inflammation is usually found in the rectum and the sigmoid colon but can be found anywhere along with the large bowel. CD can affect any part of the digestive tube from mouth to the anus but is most often found in the area of the junction of the ileum and caecum. The evidence of benefit from probiotics in UC is strong, while the evidence in Crohn’s is weak. There have been eight controlled trials involving people with UC in one study, and seven of them showed significant benefit from probiotics. Use of probiotics extended periods of remission or reduced active disease [48]. Some studies have been conducted with E. coli Nissle (EcN), Saccharomyces boulardii. These microbes have been reported to have some beneficial effects in IBD [41, 49]. E. coli probiotic was found to be as effective as a standard drug used in UC to prevent relapse. In comparison, only a small number of trials showed the benefit of probiotic yeast S. boulardii in Crohn’s disease.
4.4 Effect of probiotics in lactose intolerance
The inability of some adults to digest the sugar lactose, which is present in milk, is referred to as ‘lactose intolerance. The lactose is hydrolyzed by the enzyme lactase, which is also known as lactose- galactosehydrolase (EC 3.2.1.108). The lactose is digested into glucose and galactose, which is taken up by intestinal cells and transported to the bloodstream. The remaining lactose, which is not hydrolyzed, passes to the colon [36]. The person with lactose intolerance produces less lactase, which is inefficient in digesting much of the milk sugar. The undigested lactose causes intestinal difficulties. When lactose intolerant people consume milk, they may suffer from excess gas, diarrhea, cramps, bloating, abdominal rumblings, and flatulence. One of the reasons for excess gas could be the fermentation of glucose by gut microbiota. As lactose is an active osmotic compound, it causes osmotic pressure, leading to high water content in the feces, causing clinical symptoms as diarrhea [36]. Probiotics have gained attention as an alternative to compensate for the low level of lactase [41, 50]. Probiotic can affect at two levels: (i) By increasing hydrolytic activity in the small intestine (ii) By increasing colonic fermentation [51]. Several studies have shown the effect of probiotic yogurt in better lactose digestion in lactose-intolerant people. The probiotic bacteria used in yogurt (Lactobacillus bulgaricus and Streptococcus thermophilus) produce a significant amount of their own lactase. Evidence suggests that probiotic organisms can digest lactose in yogurt products and continue digestion in the small intestine when consumed [52]. They prevent excess gas production and reduce or eliminate diarrhea. The yogurt allows more time for lactase to digest lactose as yogurt has a thicker consistency; it takes a longer time to pass through the intestine. There is some evidence showing that Russian fermented milk- kefir or variants of kefir (sugary kefirs, kefir grains) effectively alleviate lactose intolerance [53]. There are probiotic products available in capsule, tablet, or powder form (e.g., Lactobacillus and Bifidobacterium species used in non-milk products); however, they do not appear to be as effective as yogurt.
4.5 Effect of probiotics in gastritis and stomach ulcers
A bacterium, Helicobacter pylori, causes inflammation of the mucosal barrier of the stomach. As well as frequent long-term use of nonsteroidal anti-inflammatory drugs is the major factor involved in gastric ulcer development [53]. Gastric mucosal damage is common; if not treated adequately, it may lead to gastric cancer. To eradicate H. pylori, three drugs are used simultaneously: two antibiotics and a proton pump inhibitor [54]. However, this treatment fails in most of the cases due to antibiotic-resistant strains of H. pylori; thus, a fourth antibiotic is added to standard triple therapy used previously. The therapy may cause side effects such as diarrhea, taste disturbance, and nausea.
The growing interest in probiotics to prevent or treat gastrointestinal diseases has attracted the attention of many researchers to explore the role of probiotics in the prevention and treatment of gastric ulcers [50]. Some studies have found out that when probiotics are used in conjunction with standard drugs, the rate of eradication was higher than drug therapy or probiotics alone [55]. However, side effects caused by drug therapy were reduced by probiotics. Most of the studies have used lactobacilli, but not all strains showed effects against H. pylori. Probiotic yeasts S. boulardii also showed potential therapeutic effects in gastric ulcers. S. boulardii acquires neuraminidase activity which removes sialic acid, which results in the prevention of binding of H. pylori to epithelial cells [53].
4.6 Effect of probiotic in vaginal infections
In a healthy woman, the vagina has a resident microbial population. These resident microbiota live on the lining of the vagina wall. Most of them are lactobacilli. The vaginal lactobacilli have a protective influence against urogenital infections [50]. The vaginal infections are referred to as vaginitis. In which pathogenic infections cause inflammation of the vaginal lining. If a bacterium causes vaginitis, it is known as bacterial vaginosis (BV). If vaginitis is caused by a fungus (generally Candida- a type of fungus), it is known as vaginal candidiasis (VC). Both types of vaginitis symptoms are similar, such as burning sensation during urination, itching in the vaginal area, and greyish or white discharge. Antibiotics or antifungals treat the infection. There is evidence that some women have H2O2 – secreting lactobacilli in their intestine, which lowers the risk of BV. This suggests that the rectum act as a reservoir supplement vaginal microbiota when it becomes disturbed. This information leads to the development of probiotics to protect the female reproductive system [56, 57]. Though studies have shown mixed responses. In the case of VC, a small number of clinical studies have been undertaken of probiotics against Candida. In most of the studies, probiotics didn’t show any significant effect. However, when probiotics were taken along with antifungal drugs, they improved the effectiveness of antifungal significantly [58].
4.7 Effect of probiotics in upper respiratory infections
The upper respiratory tract (URT) consists of the nose, throat, and windpipe. The nose and throat have microbiota, and the upper part of the windpipe has a changing microbial population as cilia move mucus upward to the throat. The various diseases associated with URT are common cold, sore throat, pharyngitis, epiglottitis, laryngitis, and diphtheria [29]. Most commonly, viruses such as rhinoviruses, coronaviruses, parainfluenza, and influenza viruses and bacteria such as streptococci, Mycoplasma pneumoniae, Chlamydia pneumoniae, Corynebacterium diphtheria, Staphylococcus aureus, Haemophilus influenzae type b, Streptococcus pyrogens, and Streptococcus pneumonia are associated with URT infection [59, 60]. Infection of URT may spread to the lungs, causing bronchitis and pneumonia. Some studies have shown that probiotics may reduce the severity and duration of the condition. Some probiotic bacteria such as Lactobacillus rhamnosus, Streptococcus thermophilus, Bifidobacterium animals were beneficial to reduce and prevent URT risks in children and adults [29]. Probiotics may also improve the effectiveness of influenza vaccination in the elderly. This improved immune reaction may enhance protection against acquiring influenza, although it is yet to be confirmed.
4.8 Effect of probiotics in constipation
Constipation is quite a common condition that can be acute or chronic. Constipation causes a general feeling of abdominal discomfort. To pass the stool straining may put pressure on the tissues and structures of the anal area with adverse consequences such as hemorrhoids (piles). Other diseases associated with constipation are irritable bowel syndrome and cancer of the large bowel. Several studies have been conducted using Lactobacillus rhamnosus, Lactobacillus casei, Bifidobacterium animalis, and probiotic E. coli. [61, 62]. Prebiotics also may be effective against constipation as FOS, GOS, and lactulose have mild laxative effects [63]. These laxative effects can be due to osmosis as prebiotics are soluble fibers. Prebiotics also boost bifidobacteria and lactobacilli, and these probiotic bacteria accelerate the transit of large bowel content. However, meta-analyses also indicate that groups of probiotics and synbiotics have more efficiency than individual probiotics [64].
4.9 Other benefits
The list of benefits of probiotics is not limited to the ones mentioned above. However, it includes a range of benefits that need to be explored for further human studies. Some evidences suggest that probiotics may influence cancer incidence [50]. As well as researchers are exploring various alternatives of drugs from probiotics that can be used to treat a disease like cancer and with lesser or no side effects. (i.e., L-asparaginase that is used in cancer treatment from L. casei, L. reuteri, etc. is being explored) [43, 65]. Furthermore, evidences suggests that food products with probiotic organisms may reduce serum cholesterol levels and control blood pressure. Probiotics may also prevent coronary heart disease [66, 67]. Several studies examined the effect of probiotics and prebiotics to treat allergic conditions. However, studies to prevent allergic conditions like asthma and allergic rhinitis did not show a positive response. However, studies examined that when pregnant women have probiotic intake, it improves the functioning of the mother’s immune system and indirectly improves the immature immune system of the infant, reducing the risk of allergies such as eczema and dermatitis [68]. But there are insufficient evidences to recommend probiotics as standard therapy to prevent allergies [44]. There is a close relationship between microbiota and the immune system of the skin. Consumption of probiotics has provided some protection against ultraviolet radiation from the sun. Vitreoscilla filiformis showed a beneficial effect on a patient with seborrhoeic dermatitis and atopic eczema [69]. As described earlier, LAB, especially lactobacilli and bifidobacteria, exert a beneficial effect in infants with atopic eczema. A prebiotic cream has been developed with encouraging results in controlling acne-associated organism Propionibacterium acne. However, much more exploration and research are needed to use probiotics routinely for the skin.
5. Application of probiotics
Due to the health benefits exerted by probiotic organisms, they have a wide range of applications in clinical uses and various industries such as food industries and agriculture industries. Most species of lactobacilli and bifidobacteria are used commercially. Among them L. rhamnosus, L. plantarum, L. casei, L.paracasei, B. animalis are widely used. With that in some products organism such as S. thermophilus is used.
5.1 Application of probiotics in the food industry
Increasing knowledge of probiotic benefits leads to the development of functional foods. Functional foods, also known as “nutraceuticals” or “designer foods,” are ingredients that offer health benefits that extend beyond their nutritional value. Some types contain supplements or other additional ingredients designed to improve health, and they are slowly emerging as ‘health food’ on supermarket shelves worldwide [70]. A wide variety of dairy products such as milk, yogurt, cheese, ice cream, chocolate mousse, quark, etc., include probiotic organisms to improve their nutrition characteristics [70, 71, 72, 73, 74]. Furthermore, whey-based and fortified dairy beverages are also available, including probiotic and prebiotic. L. rhamnosus GG is widely used in such beverages [75, 76]. The development of non-dairy-based products has gained attention in developed countries as a population with vegetarianism and lactose intolerance is higher [77]. Non-dairy based product includes fermented vegetable and fruit-based probiotics. Other non-dairy products such as cereal, soy, and meat-based probiotics such as fermented oats, sourdoughs, sausages, fish are available [78]. Probiotic organisms and substances secreted by them are used to preserve and enhance the quality of food. Various probiotic food products are listed in Table 2.
Other than human, probiotics application is extended to agriculture as well. One of them is probiotic farming, which is referred to as bio-intensive agriculture that combines various organic farming techniques to make soil healthier. It introduces beneficial microorganisms into the growing environment. The use of probiotics increases crop yield, limits the need for harmful fertilizers and pesticides and depletes damages caused by them. Probiotics also amplify plant’s resistance to pests and diseases. Due to antagonistic effects exhibited by probiotic bacteria by ‘induced systemic resistance,’ plants are protected from pathogenic microorganisms. Bacillus spp., LAB, Actinomycetous, etc. Protect plants from cropping hazards. Furthermore, plant probiotic microorganisms (PPM) can influence the synthesis of phytohormones and their balance in plants. Some commercial plant products that use probiotic cultures are Kodiak (Bacillus subtilis GB03), YiedShield (B. pumilis GB34), Rotex (Phlebiopsisgigantea) [21]. Probiotics used in animal feed supplements advantageously alter gastrointestinal flora and improve host animals’ health and productivity. Probiotic solely or in combination with prebiotic improves the pattern of microbial population in GIT and benefits host’s health [86]. Probiotic is generously applied in poultry and aquaculture. Some feed additives can modulate the intestinal milieu and exert beneficial substances in the intestine [87]. Probiotics gained attention to use as an alternative to antibiotics in poultry to get the product with quality and safety [88]. It also reduces their mortality rate and increases bone quality. In ruminants, probiotics increase forage intake, increasing fiber digestion rate, which results in improved weight gain, milk yield, and milk fat content [86]. Probiotic also decreases the prevalence of coliform infection in pre-ruminant calves. The use of probiotics in aquaculture prevents the adhesion of pathogens from fishing intestinal mucus.
5.3 Application of probiotics in clinical use
As described earlier, probiotics prevent or mitigate various diseases and severe symptoms by various mechanisms, but it is advisable to take care when used in immune-compromised patients. Encouraging evidences are emerging for probiotics’ efficiency in the management of pouchitis and pediatric atopic diseases. Probiotics are also helpful in preventing postoperative infections [89]. There is strong evidence that some bacterial strains are efficient in enhancing immune function. Probiotics are also beneficial in mental disorders and reduce carcinogenic activity, cholesterol level, and blood pressure [35]. The significance of probiotics in preventing traveler’s diarrhea, sepsis-associated with severe pancreatitis, ulcerative colitis, and reduction of hyper cholesterol is unproven [89, 90]. The chemotherapeutic drugs such as L-asparaginase with fewer side effects from probiotic bacteria are still being explored. A study reported the use of kimchi to treat cancer [21]. Furthermore, the development of alternative antibiotics such as lantibiotics, antimicrobial peptides (AMPs) from probiotic bacteria are being explored to reduce side effects caused by traditional drug therapies and as a next-generation drug system against resistant pathogens. LAB bacteriocin- Nisin is commercially used as a food preservative [35]. It also has biomedical applications as it exhibits antimicrobial activity against resistant pathogens and anti-biofilm properties to use in combination with therapeutic drugs [91]. Although probiotics have shown encouraging evidence of efficacy in various diseases, there is much exploration needed for standard clinical practice in humans.
6. Conclusion
Exploration of gut microbiota indicates that beneficial gut microbiota plays a crucial and constructive role in maintaining the health of host (human). The symbiotic relation of gut microbiota with host and benefits exhibited by them leads to the development of probiotics and prebiotics. Studies on various mechanisms of probiotics have shown their abilities to prevent or treat various diseases in human. Due to this efficiency, probiotics and prebiotics and their applications in various fields have shown a substantial increase in the last two decades. Probiotics are mainly applied in the food industry to develop functional foods and supplements to benefit consumers. The applications of probiotics are also extended to the agriculture industry to boost the productivity and quality of crops and animals. The emergence of encouraging evidence has given a sight to use probiotics in clinical practices with minimum side effects. However, clinical use of probiotics as standard practice is under the umbrella of research yet.
\n',keywords:"Probiotics, Prebiotics, Food products, Gut microbiome, Benefits",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/77597.pdf",chapterXML:"https://mts.intechopen.com/source/xml/77597.xml",downloadPdfUrl:"/chapter/pdf-download/77597",previewPdfUrl:"/chapter/pdf-preview/77597",totalDownloads:139,totalViews:0,totalCrossrefCites:0,dateSubmitted:"May 11th 2021",dateReviewed:"June 10th 2021",datePrePublished:"July 16th 2021",datePublished:"April 6th 2022",dateFinished:"July 16th 2021",readingETA:"0",abstract:"Most of our gut microbiota live with us in a mutually beneficial life-long relationship. The gut microbiota plays a vital role in the host’s overall health through its metabolic activities. Human microbiota might be supported by consuming friendly bacteria (probiotics) and consuming foods to improve the microbiota (prebiotics). During the last two decades, probiotics’ interest has increased with rising scientific shreds of evidence of benefits on human health. Hence, they have been exploited as various food products, mainly fermented foods. Probiotics as a treatment modality may restore normal microbiota and functioning of the gastrointestinal (GI) tract. Strong scientific evidence is associating these bacteria with the prevention and therapy of various GI disorders. (In light of the ongoing trend of probiotics, further research is needed to obtain the perspective of potential applications for better health. Probiotic applications have been extended from health applications to food and agricultural applications. The benefits of probiotics led to its applications in probiotic ‘health food’ industries and agricultural sectors.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/77597",risUrl:"/chapter/ris/77597",signatures:"Amishi Bhatt, Dhyey Kothari, Charmy Kothari and Ramesh Kothari",book:{id:"10746",type:"book",title:"Prebiotics and Probiotics",subtitle:"From Food to Health",fullTitle:"Prebiotics and Probiotics - From Food to Health",slug:"prebiotics-and-probiotics-from-food-to-health",publishedDate:"April 6th 2022",bookSignature:"Elena Franco Robles",coverURL:"https://cdn.intechopen.com/books/images_new/10746.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:"978-1-83969-576-6",printIsbn:"978-1-83969-575-9",pdfIsbn:"978-1-83969-577-3",isAvailableForWebshopOrdering:!0,editors:[{id:"219102",title:"Dr.",name:"Elena",middleName:null,surname:"Franco-Robles",slug:"elena-franco-robles",fullName:"Elena Franco-Robles"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"278193",title:"Prof.",name:"Ramesh",middleName:null,surname:"Kothari",fullName:"Ramesh Kothari",slug:"ramesh-kothari",email:"kothari1971@gmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"353395",title:"Ms.",name:"Amishi",middleName:null,surname:"Bhatt",fullName:"Amishi Bhatt",slug:"amishi-bhatt",email:"amishibhatt007@gmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"Saurashtra University",institutionURL:null,country:{name:"India"}}},{id:"353396",title:"Dr.",name:"Charmy",middleName:null,surname:"Kothari",fullName:"Charmy Kothari",slug:"charmy-kothari",email:"dr.charmykothari@gmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"426628",title:"Dr.",name:"Dhyey",middleName:null,surname:"Kothari",fullName:"Dhyey Kothari",slug:"dhyey-kothari",email:"kotharidhyey17@gmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Gut microbiota",level:"1"},{id:"sec_2_2",title:"2.1 Composition of gut microbiota",level:"2"},{id:"sec_2_3",title:"2.1.1 Microbiota of stomach",level:"3"},{id:"sec_3_3",title:"2.1.2 Microbiota of small intestine",level:"3"},{id:"sec_4_3",title:"2.1.3 Microbiota of large intestine",level:"3"},{id:"sec_6_2",title:"2.2 Benefits of gut microbiota",level:"2"},{id:"sec_7_2",title:"2.3 Disturbance of gut microbiota",level:"2"},{id:"sec_9",title:"3. Probiotics",level:"1"},{id:"sec_9_2",title:"3.1 History of Probiotics",level:"2"},{id:"sec_10_2",title:"3.2 Mechanism and action of probiotics",level:"2"},{id:"sec_11_2",title:"3.3 Types of probiotic microbes",level:"2"},{id:"sec_13",title:"4. Benefits of probiotics",level:"1"},{id:"sec_13_2",title:"4.1 Effect of probiotics on diarrhea",level:"2"},{id:"sec_14_2",title:"4.2 Effect of probiotics in Irritable Bowel Syndrome (IBS)",level:"2"},{id:"sec_15_2",title:"4.3 Effect of probiotics in inflammatory bowel disease (IBD)",level:"2"},{id:"sec_16_2",title:"4.4 Effect of probiotics in lactose intolerance",level:"2"},{id:"sec_17_2",title:"4.5 Effect of probiotics in gastritis and stomach ulcers",level:"2"},{id:"sec_18_2",title:"4.6 Effect of probiotic in vaginal infections",level:"2"},{id:"sec_19_2",title:"4.7 Effect of probiotics in upper respiratory infections",level:"2"},{id:"sec_20_2",title:"4.8 Effect of probiotics in constipation",level:"2"},{id:"sec_21_2",title:"4.9 Other benefits",level:"2"},{id:"sec_23",title:"5. Application of probiotics",level:"1"},{id:"sec_23_2",title:"5.1 Application of probiotics in the food industry",level:"2"},{id:"sec_24_2",title:"5.2 Application of probiotics in agriculture",level:"2"},{id:"sec_25_2",title:"5.3 Application of probiotics in clinical use",level:"2"},{id:"sec_27",title:"6. Conclusion",level:"1"}],chapterReferences:[{id:"B1",body:'Lebeer S, Vanderleyden J, De Keersmaecker SC. Genes and molecules of lactobacilli supporting probiotic action. Microbiology and Molecular Biology Reviews. 2008 Dec 1;72(4):728-64.'},{id:"B2",body:'Grimoud J, Durand H, Courtin C, Monsan P, Ouarné F, Theodorou V, Roques C. In vitro screening of probiotic lactic acid bacteria and prebiotic glucooligosaccharides to select effective synbiotics. Anaerobe. 2010 Oct 1;16(5):493-500.'},{id:"B3",body:'Ghoshal UC, Park H, Gwee KA. Bugs and irritable bowel syndrome: the good, the bad and the ugly. Journal of gastroenterology and hepatology. 2010 Feb;25(2):244-51.'},{id:"B4",body:'Fuller R. History and development of probiotics. InProbiotics 1992 (pp. 1-8). Springer, Dordrecht.'},{id:"B5",body:'Ridlon JM, Kang DJ, Hylemon PB, Bajaj JS. Bile acids and the gut microbiome. Current opinion in gastroenterology. 2014 May;30(3):332.'},{id:"B6",body:'Van den Abbeele P, Van de Wiele T, Verstraete W, Possemiers S. The host selects mucosal and luminal associations of coevolved gut microorganisms: a novel concept. FEMS microbiology reviews. 2011 Jul 1;35(4):681-704.'},{id:"B7",body:'Arnold JW, Roach J, Azcarate-Peril MA. Emerging technologies for gut microbiome research. Trends in microbiology. 2016 Nov 1;24(11):887-901.'},{id:"B8",body:'Bhattarai Y, Si J, Pu M, Ross OA, McLean PJ, Till L, Moor W, Grover M, Kandimalla KK, Margolis KG, Farrugia G. Role of gut microbiota in regulating gastrointestinal dysfunction and motor symptoms in a mouse model of Parkinson’s disease. Gut Microbes. 2021 Jan 1;13(1):1866974.'},{id:"B9",body:'Ogunrinola GA, Oyewale JO, Oshamika OO, Olasehinde GI. The human microbiome and its impacts on health. International Journal of Microbiology. 2020 Jun 12;2020.'},{id:"B10",body:'Cresci GA, Izzo K. Gut Microbiome. InAdult Short Bowel Syndrome 2019 Jan 1 (pp. 45-54). Academic Press.'},{id:"B11",body:'Simon GL, Gorbach SL. The human intestinal microflora. Digestive diseases and sciences. 1986 Sep 1;31(9):147-62.'},{id:"B12",body:'Hsiao WW, Metz C, Singh DP, Roth J. The microbes of the intestine: an introduction to their metabolic and signaling capabilities. Endocrinology and metabolism clinics of North America. 2008 Dec 1;37(4):857-71.'},{id:"B13",body:'Dieterich W, Schink M, Zopf Y. Microbiota in the gastrointestinal tract. Medical Sciences. 2018 Dec;6(4):116.'},{id:"B14",body:'Qin J, Li R, Raes J, Arumugam M, Burgdorf KS, Manichanh C, Nielsen T, Pons N, Levenez F, Yamada T, Mende DR. A human gut microbial gene catalogue established by metagenomic sequencing. nature. 2010 Mar;464(7285):59-65.'},{id:"B15",body:'Kho ZY, Lal SK. The human gut microbiome–a potential controller of wellness and disease. Frontiers in microbiology. 2018 Aug 14;9:1835.'},{id:"B16",body:'Tap J, Mondot S, Levenez F, Pelletier E, Caron C, Furet JP, Ugarte E, Muñoz-Tamayo R, Paslier DL, Nalin R, Dore J. Towards the human intestinal microbiota phylogenetic core. Environmental microbiology. 2009 Oct;11(10):2574-84.'},{id:"B17",body:'Anwar H, Irfan S, Hussain G, Faisal MN, Muzaffar H, Mustafa I, Mukhtar I, Malik S, Ullah MI. Gut microbiome: A new organ system in body. InParasitology and Microbiology Research 2019 Nov 5 (pp. 1-20). IntechOpen.'},{id:"B18",body:'Ghaisas S, Maher J, Kanthasamy A. Gut microbiome in health and disease: Linking the microbiome–gut–brain axis and environmental factors in the pathogenesis of systemic and neurodegenerative diseases. Pharmacology & therapeutics. 2016 Feb 1;158:52-62.'},{id:"B19",body:'Thursby E, Juge N. Introduction to the human gut microbiota. 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Functional milks and dairy beverages. International Journal of Dairy Technology. 2010 Feb;63(1):1-5.'},{id:"B39",body:'Żukiewicz-Sobczak W, Wróblewska P, Adamczuk P, Silny W. Probiotic lactic acid bacteria and their potential in the prevention and treatment of allergic diseases. Central-European journal of immunology. 2014;39(1):104.'},{id:"B40",body:'Floch MH, Montrose DC. Use of probiotics in humans: an analysis of the literature. Gastroenterology Clinics. 2005 Sep 1;34(3):547-70.'},{id:"B41",body:'Syngai GG, Gopi R, Bharali R, Dey S, Lakshmanan GA, Ahmed G. Probiotics-the versatile functional food ingredients. Journal of food science and technology. 2016 Feb 1;53(2):921-33.'},{id:"B42",body:'Blaabjerg S, Artzi DM, Aabenhus R. Probiotics for the prevention of antibiotic-associated diarrhea in outpatients—a systematic review and meta-analysis. 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Expert review of anti-infective therapy. 2006 Apr 1;4(2):261-75.'},{id:"B53",body:'Acik M, ÇAKIROĞLU FP, Altan M, BAYBO T. Alternative source of probiotics for lactose intolerance and vegan individuals: sugary kefir. Food Science and Technology. 2020 Sep;40(3):523-31.'},{id:"B54",body:'Lionetti E, Indrio F, Pavone L, Borrelli G, Cavallo L, Francavilla R. Role of probiotics in pediatric patients with Helicobacter pylori infection: a comprehensive review of the literature. Helicobacter. 2010 Apr;15(2):79-87.'},{id:"B55",body:'Franceschi F, Cazzato A, Nista EC, Scarpellini E, Roccarina D, Gigante G, Gasbarrini G, Gasbarrini A. Role of probiotics in patients with Helicobacter pylori infection. Helicobacter. 2007 Nov;12:59-63.'},{id:"B56",body:'Santos CM, Pires MC, Leao TL, Hernández ZP, Rodriguez ML, Martins AK, Miranda LS, Martins FS, Nicoli JR. Selection of Lactobacillus strains as potential probiotics for vaginitis treatment. Microbiology. 2016 Jul 1;162(7):1195-207.'},{id:"B57",body:'Reid G. Probiotics for urogenital health. Nutrition in Clinical Care. 2002 Jan;5(1):3-8.'},{id:"B58",body:'Kajander K, Myllyluoma E, Rajilić-Stojanović M, Kyrönpalo S, Rasmussen M, Järvenpää S, Zoetendal EG, De Vos WM, Vapaatalo H, Korpela R. Clinical trial: multispecies probiotic supplementation alleviates the symptoms of irritable bowel syndrome and stabilizes intestinal microbiota. Alimentary pharmacology & therapeutics. 2008 Jan;27(1):48-57.'},{id:"B59",body:'Dasaraju PV, Liu C. Chapter 93: infections of the respiratory system. Medical Microbiology. 4th ed. Galveston: University of Texas Medical Branch at Galveston. 1996.'},{id:"B60",body:'Thomas M, Bomar PA. Upper respiratory tract infection. StatPearls [Internet]. 2020 Oct 28.'},{id:"B61",body:'Fernàndez-Banares F. Nutritional care of the patient with constipation. Best Practice & Research Clinical Gastroenterology. 2006 Jan 1;20(3):575-87.'},{id:"B62",body:'Xinias I, Mavroudi A. Constipation in Childhood. An update on evaluation and management. Hippokratia. 2015 Jan;19(1):11.'},{id:"B63",body:'Macfarlane GT, Steed H, Macfarlane S. Bacterial metabolism and health-related effects of galacto-oligosaccharides and other prebiotics. Journal of applied microbiology. 2008 Feb;104(2):305-44.'},{id:"B64",body:'Kamiński M, Skonieczna-Żydecka K, Łoniewski I, Koulaouzidis A, Marlicz W. Are probiotics useful in the treatment of chronic idiopathic constipation in adults? A review of existing systematic reviews, meta-analyses, and recommendations. Przegladgastroenterologiczny. 2020;15(2):103.'},{id:"B65",body:'Aishwarya SS, Selvarajan E, Iyappan S, Rajnish KN. Recombinant l-Asparaginase II from Lactobacillus casei subsp. casei ATCC 393 and Its Anticancer Activity. Indian journal of microbiology. 2019 Sep;59(3):313-20.'},{id:"B66",body:'Wang L, Guo MJ, Gao Q, Yang JF, Yang L, Pang XL, Jiang XJ. The effects of probiotics on total cholesterol: A meta-analysis of randomized controlled trials. Medicine. 2018 Feb;97(5).'},{id:"B67",body:'Kechagia M, Basoulis D, Konstantopoulou S, Dimitriadi D, Gyftopoulou K, Skarmoutsou N, Fakiri EM. Health benefits of probiotics: a review. International Scholarly Research Notices. 2013;2013.'},{id:"B68",body:'Dotterud CK, Storrø O, Johnsen R, Øien T. Probiotics in pregnant women to prevent allergic disease: a randomized, double-blind trial. British Journal of Dermatology. 2010 Sep;163(3):616-23.'},{id:"B69",body:'Nakatsuji T, Gallo RL. Dermatological therapy by topical application of non-pathogenic bacteria. Journal of Investigative Dermatology. 2014 Jan 1;134(1):11-4.'},{id:"B70",body:'Lang T. Functional foods.'},{id:"B71",body:'Heller KJ, Bockelmann W, Schrezenmeir J, deVrese M. Cheese and its potential as a probiotic food. Handbook of fermented functional foods. 2003 Mar 26:203-25.'},{id:"B72",body:'Đurić MS, Iličić MD, Milanović SD, Carić MĐ, Tekić MN. Nutritive characteristics of probiotic quark as influenced by type of starter. Acta periodicatechnologica. 2007(38):11-9.'},{id:"B73",body:'Aragon-Alegro LC, Alegro JH, Cardarelli HR, Chiu MC, Saad SM. Potentially probiotic and synbiotic chocolate mousse. LWT-Food Science and technology. 2007 May 1;40(4):669-75.'},{id:"B74",body:'Cruz AG, Antunes AE, Sousa AL, Faria JA, Saad SM. Ice-cream as a probiotic food carrier. Food Research International. 2009 Nov 1;42(9):1233-9.'},{id:"B75",body:'Succi M, Tremonte P, Reale A, Sorrentino E, Grazia L, Pacifico S, Coppola R. Bile salt and acid tolerance of Lactobacillus rhamnosus strains isolated from Parmigiano Reggiano cheese. FEMS microbiology letters. 2005 Mar 1;244(1):129-37.'},{id:"B76",body:'Ong L, Henriksson A, Shah NP. Chemical analysis and sensory evaluation of Cheddar cheese produced with Lactobacillus acidophilus, Lb. casei, Lb. paracasei or Bifidobacterium sp. International Dairy Journal. 2007 Aug 1;17(8):937-45.'},{id:"B77",body:'Granato D, Branco GF, Nazzaro F, Cruz AG, Faria JA. Functional foods and nondairy probiotic food development: trends, concepts, and products. Comprehensive reviews in food science and food safety. 2010 May;9(3):292-302.'},{id:"B78",body:'Charalampopoulos D, Wang R, Pandiella SS, Webb C. Application of cereals and cereal components in functional foods: a review. International journal of food microbiology. 2002 Nov 15;79(1-2):131-41.'},{id:"B79",body:'Farag MA, El Hawary EA, Elmassry MM. Rediscovering acidophilus milk, its quality characteristics, manufacturing methods, flavor chemistry and nutritional value. Critical reviews in food science and nutrition. 2020 Oct 10;60(18):3024-41.'},{id:"B80",body:'Plengvidhya V, Breidt F, Lu Z, Fleming HP. DNA fingerprinting of lactic acid bacteria in sauerkraut fermentations. Applied and Environmental Microbiology. 2007 Dec 1;73(23):7697-702.'},{id:"B81",body:'Stanton C, Gardiner G, Meehan H, Collins K, Fitzgerald G, Lynch PB, Ross RP. Market potential for probiotics. The American journal of clinical nutrition. 2001 Feb 1;73(2):476s-83s.'},{id:"B82",body:'Ross RP, Fitzgerald G, Collins K, Stanton C. Cheese delivering biocultures--probiotic cheese. Australian Journal of Dairy Technology. 2002 Jul 1;57(2):71.'},{id:"B83",body:'Nielsen ES, Garnås E, Jensen KJ, Hansen LH, Olsen PS, Ritz C, Krych L, Nielsen DS. Lacto-fermented sauerkraut improves symptoms in IBS patients independent of product pasteurisation–a pilot study. Food & function. 2018;9(10):5323-35.'},{id:"B84",body:'Sun P, Wang JQ, Zhang HT. Effects of Bacillus subtilis natto on performance and immune function of preweaning calves. Journal of Dairy Science. 2010 Dec 1;93(12):5851-5.'},{id:"B85",body:'Bartkiene E, Lele V, Ruzauskas M, Domig KJ, Starkute V, Zavistanaviciute P, Bartkevics V, Pugajeva I, Klupsaite D, Juodeikiene G, Mickiene R. Lactic acid bacteria isolation from spontaneous sourdough and their characterization including antimicrobial and antifungal properties evaluation. Microorganisms. 2020 Jan;8(1):64.'},{id:"B86",body:'Yirga H. The use of probiotics in animal nutrition. J. Prob. Health. 2015;3(2):1-0.'},{id:"B87",body:'Kabir SM. The role of probiotics in the poultry industry. International Journal of Molecular Sciences. 2009 Aug;10(8):3531-46.'},{id:"B88",body:'Langhout P. New additives for broiler chickens. World poultry. 2000;16(3):22-7.'},{id:"B89",body:'Gill HS, Guarner F. Probiotics and human health: a clinical perspective. Postgraduate Medical Journal. 2004 Sep 1;80(947):516-26.'},{id:"B90",body:'Tanriover MD, Aksoy DY, Unal S. Use of probiotics in various diseases: Evidence and promises. Pol Arch Med Wewn. 2012 Jan 1;122(Suppl 1):S72-7.'},{id:"B91",body:'Shin JM, Gwak JW, Kamarajan P, Fenno JC, Rickard AH, Kapila YL. Biomedical applications of nisin. Journal of applied microbiology. 2016 Jun;120(6):1449-65.'}],footnotes:[],contributors:[{corresp:null,contributorFullName:"Amishi Bhatt",address:null,affiliation:'
Department of Biosciences, Saurashtra University, India
Department of Biosciences, Saurashtra University, India
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The objective of this research was to estimate the carrying capacity (K), the catchability coefficient (q), the maximum sustainable yield (MSY) (tons), and the optimal fishing effort (fMSY) (traps). For this, a time series from 1998 to 2012 was used for the catch and number. The Fox (1970) and Schaefer (1954) models included in A Surplus-Production Model Incorporating Covariates (ASPIC) software were employed for this study. A set of statistical variability estimators and the Akaike?s, Bayesian, and Hannan-Quinn information criteria were used for the selection of models. The results obtained by the fox model were K = 54,000, q = 0.00008798, MSY = 2567 and fMSY = 146,900 traps, whereas for the Schaefer model, the results were K = 28,370, q = 0.00002425, MSY = 2008, and fMSY = 58,390. The model with the best adjustment was that of Schaefer. It is concluded that the fishing resource has been overexploited during the period 2003–2011, with an average annual surplus of 670 tons and 25,000 traps. It is recommended to consider the MSY and fMSY values of the Schaefer model for the National Fishing Charter (NFC).",signatures:"Jorge Homero Rodriguez Castro, Sandra Edith Olmeda de la Fuente, Wanda Ortiz Baez, Alfonso Correa Sandoval and Jose Alberto Ramirez de León",authors:[{id:"297469",title:"Dr.",name:"Jorge Homero",surname:"Rodríguez-Castro",fullName:"Jorge Homero Rodríguez-Castro",slug:"jorge-homero-rodriguez-castro",email:"rodriguezjh@hotmail.com"},{id:"298745",title:"MSc.",name:"Sandra Edith",surname:"Olmeda-De-La-Fuente",fullName:"Sandra Edith Olmeda-De-La-Fuente",slug:"sandra-edith-olmeda-de-la-fuente",email:"olmedasandrafuente@hotmail.com"},{id:"298746",title:"Dr.",name:"Alfonso",surname:"Correa-Sandoval",fullName:"Alfonso Correa-Sandoval",slug:"alfonso-correa-sandoval",email:"alf_correas@hotmail.com"},{id:"298747",title:"Dr.",name:"Jose Alberto",surname:"Ramírez-De-Leon",fullName:"Jose Alberto Ramírez-De-Leon",slug:"jose-alberto-ramirez-de-leon",email:"ramirez@docentes.uat.edu.mx"}],book:{id:"8159",title:"Crustacea",slug:"crustacea",productType:{id:"1",title:"Edited Volume"}}}],collaborators:[{id:"181100",title:"Ph.D.",name:"Luis",surname:"Mejia-Ortiz",slug:"luis-mejia-ortiz",fullName:"Luis Mejia-Ortiz",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Quintana Roo",institutionURL:null,country:{name:"Mexico"}}},{id:"185425",title:"Dr.",name:"Marilu",surname:"Lopez-Mejia",slug:"marilu-lopez-mejia",fullName:"Marilu Lopez-Mejia",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"185428",title:"Prof.",name:"Keith",surname:"Crandall",slug:"keith-crandall",fullName:"Keith Crandall",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"185429",title:"Dr.",name:"Oscar",surname:"Frausto-Martinez",slug:"oscar-frausto-martinez",fullName:"Oscar Frausto-Martinez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/185429/images/17673_n.jpg",biography:"Dr.-Ing. Geo.",institutionString:null,institution:null},{id:"215819",title:"MSc.",name:"Juan C.",surname:"Tejeda-Mazariegos",slug:"juan-c.-tejeda-mazariegos",fullName:"Juan C. Tejeda-Mazariegos",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"296673",title:"Dr.",name:"Osikemekha",surname:"Anani",slug:"osikemekha-anani",fullName:"Osikemekha Anani",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:"Dr. O.A, Anani is a Lecturer in the Department of Biological Science, Edo University Iyamho, Nigeria. \r\nHe leads a research group in the Laboratory of Ecotoxicology and Forensic Biology, Department of Biological Science, Edo University Iyamho and the University of Benin, Benin City, Nigeria that focuses on the Ecological and Health risk Assessment on portable water and consumables using geospatial modeling and several Environmentric approaches. \r\nHe is currently proposing a study on the impacts of climate on the distribution of freshwater aquatic species and sediment enzymology.",institutionString:null,institution:{name:"Edo University Iyamho",institutionURL:null,country:{name:"Nigeria"}}},{id:"296677",title:"Prof.",name:"John",surname:"Olomukoro",slug:"john-olomukoro",fullName:"John Olomukoro",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"296834",title:"Dr.",name:"Walter",surname:"Reyes",slug:"walter-reyes",fullName:"Walter Reyes",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"297543",title:"Mr.",name:"Jesus E.",surname:"Cupul-Pool",slug:"jesus-e.-cupul-pool",fullName:"Jesus E. Cupul-Pool",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"297544",title:"Mr.",name:"Alfredo G.",surname:"Baez-Melendres",slug:"alfredo-g.-baez-melendres",fullName:"Alfredo G. Baez-Melendres",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null}]},generic:{page:{slug:"prior-publication-policy",title:"Prior Publication Policy",intro:"
The Internet has irrevocably changed the dynamics of scholarly communication and publishing. Consequently, we find it necessary to indicate, unambiguously, our definition of what we consider to be a published scientific work.
A significant number of working papers, early drafts, and similar work in progress are openly shared online between members of the scientific community. It has become common to announce one’s own research on a personal website or a blog to gather comments and suggestions from other researchers. Such works and online postings are, indeed, published in the sense that they are made publicly available. However, this does not mean that if submitted for publication by IntechOpen they are not original works. We differentiate between reviewed and non-reviewed works when determining whether a work is original and has been published in a scholarly sense or not.
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The significance of Peer Review cannot be overstated when it comes to defining, in our terms, what constitutes a published scientific work. Peer Review is widely considered to be the cornerstone of modern publishing processes and the key value-adding contribution to a scholarly manuscript that a publisher can make.
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Other than the issue of originality, research misconduct is another major issue that all publishers have to address. IntechOpen’s Retraction & Correction Policy and various publication ethics guidelines identify both redundant publication and (self)plagiarism to fall within the definition of research misconduct, thus constituting grounds for rejection or the issue of a Retraction if the work has already been published.
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In order to facilitate the tracking of a manuscript’s publishing history and its development from its earliest draft to the manuscript submitted, we encourage Authors to disclose any instances of a manuscript’s prior publication, whether it be through a conference presentation, a newspaper article, a working paper publicly available in a repository or a blog post.
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A note to the Academic Editor containing detailed information about a submitted manuscript’s previous public availability is the preferred means of reporting prior publication. This helps us determine if there are any earlier versions of a manuscript that should be disclosed to our readers or if any of those earlier versions should be cited and listed in a manuscript’s references.
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Some basic information about the editorial treatment of different varieties of prior publication is laid out below:
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1. CONFERENCE PAPERS & PRESENTATIONS
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Given that conference papers and presentations generally pass through some sort of peer or editorial review, we consider them to be published in the accepted scholarly sense, particularly if they are published as a part of conference proceedings.
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All submitted manuscripts originating from a previously published conference paper must contain at least 50% of new original content to be accepted for review and considered for publication.
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Authors are required to report any links their manuscript might have with their earlier conference papers and presentations in a note to the Academic Editor, as well as in the manuscript itself. Additionally, Authors should obtain any necessary permissions from the publisher of their conference paper if copyright transfer occurred during the publishing process. Failure to do so may prevent Us from publishing an otherwise worthy work.
\\n\\n
2. NEWSPAPER & MAGAZINE ARTICLES
\\n\\n
Newspaper and magazine articles usually do not pass through any extensive peer or editorial review and we do not consider them to be published in the scholarly sense. Articles appearing in newspapers and magazines rarely possess the depth and structure characteristic of scholarly articles.
\\n\\n
Submitted manuscripts stemming from a previous newspaper or magazine article will be accepted for review and considered for publication. However, Authors are strongly advised to report any such publication in an accompanying note to the External Editor.
\\n\\n
As with the conference papers and presentations, Authors should obtain any necessary permissions from the newspaper or magazine that published the work, and indicate that they have done so in a note to the External Editor.
\\n\\n
3. GREY LITERATURE
\\n\\n
White papers, working papers, technical reports and all other forms of papers which fall within the scope of the ‘Luxembourg definition’ of grey literature do not pass through any extensive peer or editorial review and we do not consider them to be published in the scholarly sense.
\\n\\n
Although such papers are regularly made publicly available via personal websites and institutional repositories, their general purpose is to gather comments and feedback from Authors’ colleagues in order to further improve a manuscript intended for future publication.
\\n\\n
When submitting their work, Authors are required to disclose the existence of any publicly available earlier drafts in a note to the Academic Editor. In cases where earlier drafts of the submitted version of the manuscript are publicly available, any overlap between the versions will generally not be considered an instance of self-plagiarism.
\\n\\n
4. SOCIAL MEDIA, BLOG & MESSAGE BOARD POSTINGS
\\n\\n
We feel that social media, blogs and message boards are generally used with the same intention as grey literature, to formulate ideas for a manuscript and gather early feedback from like-minded researchers in order to improve a particular piece of work before submitting it for publication. Therefore, we do not consider such internet postings to be publication in the scholarly sense.
\\n\\n
Nevertheless, Authors are encouraged to disclose the existence of any internet postings in which they outline and describe their research or posted passages of their manuscripts in a note to the Academic Editor. Please note that we will not strictly enforce this request in the same way that we would instructions we consider to be part of our conditions of acceptance for publication. We understand that it may be difficult to keep track of all one’s internet postings in which the researcher´s current work might be mentioned.
\\n\\n
In cases where there is any overlap between the Author´s submitted manuscript and related internet postings, we will generally not consider it to be an instance of self-plagiarism. This also holds true for any co-Author as well.
A significant number of working papers, early drafts, and similar work in progress are openly shared online between members of the scientific community. It has become common to announce one’s own research on a personal website or a blog to gather comments and suggestions from other researchers. Such works and online postings are, indeed, published in the sense that they are made publicly available. However, this does not mean that if submitted for publication by IntechOpen they are not original works. We differentiate between reviewed and non-reviewed works when determining whether a work is original and has been published in a scholarly sense or not.
\n\n
The significance of Peer Review cannot be overstated when it comes to defining, in our terms, what constitutes a published scientific work. Peer Review is widely considered to be the cornerstone of modern publishing processes and the key value-adding contribution to a scholarly manuscript that a publisher can make.
\n\n
Other than the issue of originality, research misconduct is another major issue that all publishers have to address. IntechOpen’s Retraction & Correction Policy and various publication ethics guidelines identify both redundant publication and (self)plagiarism to fall within the definition of research misconduct, thus constituting grounds for rejection or the issue of a Retraction if the work has already been published.
\n\n
In order to facilitate the tracking of a manuscript’s publishing history and its development from its earliest draft to the manuscript submitted, we encourage Authors to disclose any instances of a manuscript’s prior publication, whether it be through a conference presentation, a newspaper article, a working paper publicly available in a repository or a blog post.
\n\n
A note to the Academic Editor containing detailed information about a submitted manuscript’s previous public availability is the preferred means of reporting prior publication. This helps us determine if there are any earlier versions of a manuscript that should be disclosed to our readers or if any of those earlier versions should be cited and listed in a manuscript’s references.
\n\n
Some basic information about the editorial treatment of different varieties of prior publication is laid out below:
\n\n
1. CONFERENCE PAPERS & PRESENTATIONS
\n\n
Given that conference papers and presentations generally pass through some sort of peer or editorial review, we consider them to be published in the accepted scholarly sense, particularly if they are published as a part of conference proceedings.
\n\n
All submitted manuscripts originating from a previously published conference paper must contain at least 50% of new original content to be accepted for review and considered for publication.
\n\n
Authors are required to report any links their manuscript might have with their earlier conference papers and presentations in a note to the Academic Editor, as well as in the manuscript itself. Additionally, Authors should obtain any necessary permissions from the publisher of their conference paper if copyright transfer occurred during the publishing process. Failure to do so may prevent Us from publishing an otherwise worthy work.
\n\n
2. NEWSPAPER & MAGAZINE ARTICLES
\n\n
Newspaper and magazine articles usually do not pass through any extensive peer or editorial review and we do not consider them to be published in the scholarly sense. Articles appearing in newspapers and magazines rarely possess the depth and structure characteristic of scholarly articles.
\n\n
Submitted manuscripts stemming from a previous newspaper or magazine article will be accepted for review and considered for publication. However, Authors are strongly advised to report any such publication in an accompanying note to the External Editor.
\n\n
As with the conference papers and presentations, Authors should obtain any necessary permissions from the newspaper or magazine that published the work, and indicate that they have done so in a note to the External Editor.
\n\n
3. GREY LITERATURE
\n\n
White papers, working papers, technical reports and all other forms of papers which fall within the scope of the ‘Luxembourg definition’ of grey literature do not pass through any extensive peer or editorial review and we do not consider them to be published in the scholarly sense.
\n\n
Although such papers are regularly made publicly available via personal websites and institutional repositories, their general purpose is to gather comments and feedback from Authors’ colleagues in order to further improve a manuscript intended for future publication.
\n\n
When submitting their work, Authors are required to disclose the existence of any publicly available earlier drafts in a note to the Academic Editor. In cases where earlier drafts of the submitted version of the manuscript are publicly available, any overlap between the versions will generally not be considered an instance of self-plagiarism.
\n\n
4. SOCIAL MEDIA, BLOG & MESSAGE BOARD POSTINGS
\n\n
We feel that social media, blogs and message boards are generally used with the same intention as grey literature, to formulate ideas for a manuscript and gather early feedback from like-minded researchers in order to improve a particular piece of work before submitting it for publication. Therefore, we do not consider such internet postings to be publication in the scholarly sense.
\n\n
Nevertheless, Authors are encouraged to disclose the existence of any internet postings in which they outline and describe their research or posted passages of their manuscripts in a note to the Academic Editor. Please note that we will not strictly enforce this request in the same way that we would instructions we consider to be part of our conditions of acceptance for publication. We understand that it may be difficult to keep track of all one’s internet postings in which the researcher´s current work might be mentioned.
\n\n
In cases where there is any overlap between the Author´s submitted manuscript and related internet postings, we will generally not consider it to be an instance of self-plagiarism. This also holds true for any co-Author as well.
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There are two hosts for the transmission of Babesia spp., viz. invertebrate (tick) and vertebrate host. Dogs are one among the many targets of Babesia spp., causing canine babesiosis, and now there are clinical evidences of possible vertical transmission too. Dogs of all ages can be affected with Babesia spp., but young puppies are more commonly affected. Considering advanced diagnostic techniques, for an early and specific detection of acute infections, an AgELISA that is potentially translatable to a rapid diagnostic test design is reported. Different molecular techniques used for identification and differentiation of the various species of Babesia are semi-nested PCR, reverse line blotting and PCR-restriction fragment length polymorphism analysis. Treatment consists of three components: treatment with antiprotozoal agents to eliminate the parasite, blood transfusions to treat severe anaemia and supportive care for the complications and metabolic derangements. 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Lucas, Linda Le-Wendling and F. Kayser Enneking",authors:[{id:"74071",title:"Dr.",name:"F. Kayser",middleName:null,surname:"Enneking",slug:"f.-kayser-enneking",fullName:"F. Kayser Enneking"},{id:"74078",title:"Dr.",name:"Stephen",middleName:null,surname:"Lucas",slug:"stephen-lucas",fullName:"Stephen Lucas"},{id:"74084",title:"Dr.",name:"Linda",middleName:null,surname:"Le-Wendling",slug:"linda-le-wendling",fullName:"Linda Le-Wendling"}]},{id:"65176",title:"Veterinary Drug Residues in Meat and Meat Products: Occurrence, Detection and Implications",slug:"veterinary-drug-residues-in-meat-and-meat-products-occurrence-detection-and-implications",totalDownloads:2969,totalCrossrefCites:9,totalDimensionsCites:18,abstract:"Application of veterinary drugs in livestock production is inevitable as they are essential for treatment of diseases, prevention of diseases, modification of physiological functions, improvement of growth and productivity as well as for ensuring food safety. However, recent reports have revealed that the use of veterinary drugs in large amounts and consistently could result in deposition of antimicrobial residues in muscle and organs of animal. Consumption of these residues in animal products may pose health risk to consumers including development of antibiotic resistance bacteria, allergy, reproductive disorder and hypersensitivity reaction. It is in line with this that this chapter seeks to examine the cause, occurrence, mode of detection, health implication and possible solution to veterinary drugs residues in meat and meat products.",book:{id:"8634",slug:"veterinary-medicine-and-pharmaceuticals",title:"Veterinary Medicine and Pharmaceuticals",fullTitle:"Veterinary Medicine and Pharmaceuticals"},signatures:"Andrew Bamidele Falowo and Oluwakamisi Festus Akimoladun",authors:[{id:"271285",title:"Dr.",name:"Andrew",middleName:"Bamidele",surname:"Falowo",slug:"andrew-falowo",fullName:"Andrew Falowo"},{id:"288263",title:"Mr.",name:"Oluwakamisi Festus",middleName:null,surname:"Akimoladun",slug:"oluwakamisi-festus-akimoladun",fullName:"Oluwakamisi Festus Akimoladun"}]},{id:"26133",title:"Creation of New Local Anesthetics Based on Quinoline Derivatives and Related Heterocycles",slug:"creation-of-new-local-anesthetics-based-on-quinoline-derivatives-and-related-heterocycles",totalDownloads:3283,totalCrossrefCites:0,totalDimensionsCites:0,abstract:null,book:{id:"761",slug:"pain-management-current-issues-and-opinions",title:"Pain Management",fullTitle:"Pain Management - Current Issues and Opinions"},signatures:"Igor Ukrainets",authors:[{id:"88171",title:"Dr.",name:"Igor",middleName:null,surname:"Ukrainets",slug:"igor-ukrainets",fullName:"Igor Ukrainets"}]},{id:"26152",title:"Non-Pharmacological Therapies in Pain Management",slug:"non-pharmacological-therapies-in-pain-management",totalDownloads:59099,totalCrossrefCites:7,totalDimensionsCites:20,abstract:null,book:{id:"761",slug:"pain-management-current-issues-and-opinions",title:"Pain Management",fullTitle:"Pain Management - Current Issues and Opinions"},signatures:"Yurdanur Demir",authors:[{id:"80570",title:"Dr.",name:"Yurdanur",middleName:null,surname:"Demir",slug:"yurdanur-demir",fullName:"Yurdanur Demir"}]},{id:"63964",title:"Antimicrobial Usage and Resistance in Dairy Cattle Production",slug:"antimicrobial-usage-and-resistance-in-dairy-cattle-production",totalDownloads:1022,totalCrossrefCites:3,totalDimensionsCites:6,abstract:"Antimicrobial resistance (AMR) has been a public health threat globally, with millions of lives lost due to AMR infections each year. The cases of AMR continue to escalate and cause devastating effect to both humans and animals. AMR contributes to high morbidity and mortality of the livestock, which results in staggering economic losses to the livestock producers. The main factor for AMR to arise in this industry is mainly due to the eagerness of livestock producers to meet high demand by using antimicrobials to promote animal growth and disease prevention. From a public health perspective, AMR in dairy cattle can also jeopardize human population due to the potential dissemination of AMR pathogens to humans via consumption of infected dairy products or direct contact with infected dairy cattle. At the current rate of unrestricted antimicrobial usage, AMR will be expedited and soon we will run out of effective treatment for even the simplest infection. World Health Organization (WHO) has issued a set of guidelines for the use of medically important antimicrobials on animals to mitigate the adverse consequences of AMR on human. Thus, this chapter will explain antimicrobial usage in dairy cattle production and the recent approaches and challenges on AMR.",book:{id:"8634",slug:"veterinary-medicine-and-pharmaceuticals",title:"Veterinary Medicine and Pharmaceuticals",fullTitle:"Veterinary Medicine and Pharmaceuticals"},signatures:"Enli Loo, Kok Song Lai and Rozaihan Mansor",authors:[{id:"221544",title:"Dr.",name:"Kok-Song",middleName:null,surname:"Lai",slug:"kok-song-lai",fullName:"Kok-Song Lai"},{id:"240934",title:"Dr.",name:"Rozaihan",middleName:null,surname:"Mansor",slug:"rozaihan-mansor",fullName:"Rozaihan Mansor"},{id:"264957",title:"Mr.",name:"Loo",middleName:null,surname:"Enli",slug:"loo-enli",fullName:"Loo Enli"}]}],onlineFirstChaptersFilter:{topicId:"1193",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:89,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:32,numberOfPublishedChapters:318,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:133,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:5,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:15,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. 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\r\n\tTransforming our World: the 2030 Agenda for Sustainable Development endorsed by United Nations and 193 Member States, came into effect on Jan 1, 2016, to guide decision making and actions to the year 2030 and beyond. Central to this Agenda are 17 Goals, 169 associated targets and over 230 indicators that are reviewed annually. The vision envisaged in the implementation of the SDGs is centered on the five Ps: People, Planet, Prosperity, Peace and Partnership. This call for renewed focused efforts ensure we have a safe and healthy planet for current and future generations.
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\r\n\tThis Series focuses on covering research and applied research involving the five Ps through the following topics:
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\r\n\t1. Sustainable Economy and Fair Society that relates to SDG 1 on No Poverty, SDG 2 on Zero Hunger, SDG 8 on Decent Work and Economic Growth, SDG 10 on Reduced Inequalities, SDG 12 on Responsible Consumption and Production, and SDG 17 Partnership for the Goals
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\r\n\t2. Health and Wellbeing focusing on SDG 3 on Good Health and Wellbeing and SDG 6 on Clean Water and Sanitation
\r\n
\r\n\t
\r\n
\r\n\t3. Inclusivity and Social Equality involving SDG 4 on Quality Education, SDG 5 on Gender Equality, and SDG 16 on Peace, Justice and Strong Institutions
\r\n
\r\n\t
\r\n
\r\n\t4. Climate Change and Environmental Sustainability comprising SDG 13 on Climate Action, SDG 14 on Life Below Water, and SDG 15 on Life on Land
\r\n
\r\n\t
\r\n
\r\n\t5. Urban Planning and Environmental Management embracing SDG 7 on Affordable Clean Energy, SDG 9 on Industry, Innovation and Infrastructure, and SDG 11 on Sustainable Cities and Communities.
\r\n
\r\n\t
\r\n
\r\n\tThe series also seeks to support the use of cross cutting SDGs, as many of the goals listed above, targets and indicators are all interconnected to impact our lives and the decisions we make on a daily basis, making them impossible to tie to a single topic.
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He is also a faculty member in the Molecular Oncology Program. He obtained his MSc and Ph.D. at Oregon State University and Texas Tech University, respectively. He pursued his postdoctoral studies at Rutgers University Medical School and the National Institutes of Health (NIH/NIDDK), USA. His research focuses on biochemistry, biophysics, genetics, molecular biology, and molecular medicine with specialization in the fields of drug design, protein structure-function, protein folding, prions, microRNA, pseudogenes, molecular cancer, epigenetics, metabolites, proteomics, genomics, protein expression, and characterization by spectroscopic and calorimetric methods.",institutionString:"University of Health Sciences",institution:null},{id:"180528",title:"Dr.",name:"Hiroyuki",middleName:null,surname:"Kagechika",slug:"hiroyuki-kagechika",fullName:"Hiroyuki Kagechika",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180528/images/system/180528.jpg",biography:"Hiroyuki Kagechika received his bachelor’s degree and Ph.D. in Pharmaceutical Sciences from the University of Tokyo, Japan, where he served as an associate professor until 2004. He is currently a professor at the Institute of Biomaterials and Bioengineering (IBB), Tokyo Medical and Dental University (TMDU). From 2010 to 2012, he was the dean of the Graduate School of Biomedical Science. Since 2012, he has served as the vice dean of the Graduate School of Medical and Dental Sciences. He has been the director of the IBB since 2020. Dr. Kagechika’s major research interests are the medicinal chemistry of retinoids, vitamins D/K, and nuclear receptors. He has developed various compounds including a drug for acute promyelocytic leukemia.",institutionString:"Tokyo Medical and Dental University",institution:{name:"Tokyo Medical and Dental University",country:{name:"Japan"}}},{id:"94311",title:"Prof.",name:"Martins",middleName:"Ochubiojo",surname:"Ochubiojo Emeje",slug:"martins-ochubiojo-emeje",fullName:"Martins Ochubiojo Emeje",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94311/images/system/94311.jpeg",biography:"Martins Emeje obtained a BPharm with distinction from Ahmadu Bello University, Nigeria, and an MPharm and Ph.D. from the University of Nigeria (UNN), where he received the best Ph.D. award and was enlisted as UNN’s “Face of Research.” He established the first nanomedicine center in Nigeria and was the pioneer head of the intellectual property and technology transfer as well as the technology innovation and support center. Prof. Emeje’s several international fellowships include the prestigious Raman fellowship. He has published more than 150 articles and patents. He is also the head of R&D at NIPRD and holds a visiting professor position at Nnamdi Azikiwe University, Nigeria. He has a postgraduate certificate in Project Management from Walden University, Minnesota, as well as a professional teaching certificate and a World Bank certification in Public Procurement. Prof. Emeje was a national chairman of academic pharmacists in Nigeria and the 2021 winner of the May & Baker Nigeria Plc–sponsored prize for professional service in research and innovation.",institutionString:"National Institute for Pharmaceutical Research and Development",institution:{name:"National Institute for Pharmaceutical Research and Development",country:{name:"Nigeria"}}},{id:"268659",title:"Ms.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/268659/images/8143_n.jpg",biography:"Dr. Zhan received his undergraduate and graduate training in the fields of preventive medicine and epidemiology and statistics at the West China University of Medical Sciences in China during 1989 to 1999. He received his post-doctoral training in oncology and cancer proteomics for two years at the Cancer Research Institute of Human Medical University in China. In 2001, he went to the University of Tennessee Health Science Center (UTHSC) in USA, where he was a post-doctoral researcher and focused on mass spectrometry and cancer proteomics. Then, he was appointed as an Assistant Professor of Neurology, UTHSC in 2005. He moved to the Cleveland Clinic in USA as a Project Scientist/Staff in 2006 where he focused on the studies of eye disease proteomics and biomarkers. He returned to UTHSC as an Assistant Professor of Neurology in the end of 2007, engaging in proteomics and biomarker studies of lung diseases and brain tumors, and initiating the studies of predictive, preventive, and personalized medicine (PPPM) in cancer. In 2010, he was promoted to Associate Professor of Neurology, UTHSC. Currently, he is a Professor at Xiangya Hospital of Central South University in China, Fellow of Royal Society of Medicine (FRSM), the European EPMA National Representative in China, Regular Member of American Association for the Advancement of Science (AAAS), European Cooperation of Science and Technology (e-COST) grant evaluator, Associate Editors of BMC Genomics, BMC Medical Genomics, EPMA Journal, and Frontiers in Endocrinology, Executive Editor-in-Chief of Med One. He has\npublished 116 peer-reviewed research articles, 16 book chapters, 2 books, and 2 US patents. His current main research interest focuses on the studies of cancer proteomics and biomarkers, and the use of modern omics techniques and systems biology for PPPM in cancer, and on the development and use of 2DE-LC/MS for the large-scale study of human proteoforms.",institutionString:null,institution:{name:"Xiangya Hospital Central South University",country:{name:"China"}}},{id:"40482",title:null,name:"Rizwan",middleName:null,surname:"Ahmad",slug:"rizwan-ahmad",fullName:"Rizwan Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/40482/images/system/40482.jpeg",biography:"Dr. Rizwan Ahmad is a University Professor and Coordinator, Quality and Development, College of Medicine, Imam Abdulrahman bin Faisal University, Saudi Arabia. Previously, he was Associate Professor of Human Function, Oman Medical College, Oman, and SBS University, Dehradun. Dr. Ahmad completed his education at Aligarh Muslim University, Aligarh. He has published several articles in peer-reviewed journals, chapters, and edited books. His area of specialization is free radical biochemistry and autoimmune diseases.",institutionString:"Imam Abdulrahman Bin Faisal University",institution:{name:"Imam Abdulrahman Bin Faisal University",country:{name:"Saudi Arabia"}}},{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/41865/images/system/41865.jpg",biography:"Farid A. Badria, Ph.D., is the recipient of several awards, including The World Academy of Sciences (TWAS) Prize for Public Understanding of Science; the World Intellectual Property Organization (WIPO) Gold Medal for best invention; Outstanding Arab Scholar, Kuwait; and the Khwarizmi International Award, Iran. He has 250 publications, 12 books, 20 patents, and several marketed pharmaceutical products to his credit. He continues to lead research projects on developing new therapies for liver, skin disorders, and cancer. Dr. Badria was listed among the world’s top 2% of scientists in medicinal and biomolecular chemistry in 2019 and 2020. He is a member of the Arab Development Fund, Kuwait; International Cell Research Organization–United Nations Educational, Scientific and Cultural Organization (ICRO–UNESCO), Chile; and UNESCO Biotechnology France",institutionString:"Mansoura University",institution:{name:"Mansoura University",country:{name:"Egypt"}}},{id:"329385",title:"Dr.",name:"Rajesh K.",middleName:"Kumar",surname:"Singh",slug:"rajesh-k.-singh",fullName:"Rajesh K. Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329385/images/system/329385.png",biography:"Dr. Singh received a BPharm (2003) and MPharm (2005) from Panjab University, Chandigarh, India, and a Ph.D. (2013) from Punjab Technical University (PTU), Jalandhar, India. He has more than sixteen years of teaching experience and has supervised numerous postgraduate and Ph.D. students. He has to his credit more than seventy papers in SCI- and SCOPUS-indexed journals, fifty-five conference proceedings, four books, six Best Paper Awards, and five projects from different government agencies. He is currently an editorial board member of eight international journals and a reviewer for more than fifty scientific journals. He received Top Reviewer and Excellent Peer Reviewer Awards from Publons in 2016 and 2017, respectively. He is also on the panel of The International Reviewer for reviewing research proposals for grants from the Royal Society. He also serves as a Publons Academy mentor and Bentham brand ambassador.",institutionString:"Punjab Technical University",institution:{name:"Punjab Technical University",country:{name:"India"}}},{id:"142388",title:"Dr.",name:"Thiago",middleName:"Gomes",surname:"Gomes Heck",slug:"thiago-gomes-heck",fullName:"Thiago Gomes Heck",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/142388/images/7259_n.jpg",biography:null,institutionString:null,institution:{name:"Universidade Regional do Noroeste do Estado do Rio Grande do Sul",country:{name:"Brazil"}}},{id:"336273",title:"Assistant Prof.",name:"Janja",middleName:null,surname:"Zupan",slug:"janja-zupan",fullName:"Janja Zupan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/336273/images/14853_n.jpeg",biography:"Janja Zupan graduated in 2005 at the Department of Clinical Biochemistry (superviser prof. dr. Janja Marc) in the field of genetics of osteoporosis. Since November 2009 she is working as a Teaching Assistant at the Faculty of Pharmacy, Department of Clinical Biochemistry. In 2011 she completed part of her research and PhD work at Institute of Genetics and Molecular Medicine, University of Edinburgh. She finished her PhD entitled The influence of the proinflammatory cytokines on the RANK/RANKL/OPG in bone tissue of osteoporotic and osteoarthritic patients in 2012. From 2014-2016 she worked at the Institute of Biomedical Sciences, University of Aberdeen as a postdoctoral research fellow on UK Arthritis research project where she gained knowledge in mesenchymal stem cells and regenerative medicine. She returned back to University of Ljubljana, Faculty of Pharmacy in 2016. She is currently leading project entitled Mesenchymal stem cells-the keepers of tissue endogenous regenerative capacity facing up to aging of the musculoskeletal system funded by Slovenian Research Agency.",institutionString:null,institution:{name:"University of Ljubljana",country:{name:"Slovenia"}}},{id:"357453",title:"Dr.",name:"Radheshyam",middleName:null,surname:"Maurya",slug:"radheshyam-maurya",fullName:"Radheshyam Maurya",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/357453/images/16535_n.jpg",biography:null,institutionString:null,institution:{name:"University of Hyderabad",country:{name:"India"}}},{id:"418340",title:"Dr.",name:"Jyotirmoi",middleName:null,surname:"Aich",slug:"jyotirmoi-aich",fullName:"Jyotirmoi Aich",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038Ugi5QAC/Profile_Picture_2022-04-15T07:48:28.png",biography:"Biotechnologist with 15 years of research including 6 years of teaching experience. Demonstrated record of scientific achievements through consistent publication record (H index = 13, with 874 citations) in high impact journals such as Nature Communications, Oncotarget, Annals of Oncology, PNAS, and AJRCCM, etc. Strong research professional with a post-doctorate from ACTREC where I gained experimental oncology experience in clinical settings and a doctorate from IGIB where I gained expertise in asthma pathophysiology. A well-trained biotechnologist with diverse experience on the bench across different research themes ranging from asthma to cancer and other infectious diseases. An individual with a strong commitment and innovative mindset. Have the ability to work on diverse projects such as regenerative and molecular medicine with an overall mindset of improving healthcare.",institutionString:"DY Patil Deemed to Be University",institution:null},{id:"349288",title:"Prof.",name:"Soumya",middleName:null,surname:"Basu",slug:"soumya-basu",fullName:"Soumya Basu",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035QxIDQA0/Profile_Picture_2022-04-15T07:47:01.jpg",biography:"Soumya Basu, Ph.D., is currently working as an Associate Professor at Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India. With 16+ years of trans-disciplinary research experience in Drug Design, development, and pre-clinical validation; 20+ research article publications in journals of repute, 9+ years of teaching experience, trained with cross-disciplinary education, Dr. Basu is a life-long learner and always thrives for new challenges.\r\nHer research area is the design and synthesis of small molecule partial agonists of PPAR-γ in lung cancer. She is also using artificial intelligence and deep learning methods to understand the exosomal miRNA’s role in cancer metastasis. Dr. Basu is the recipient of many awards including the Early Career Research Award from the Department of Science and Technology, Govt. of India. She is a reviewer of many journals like Molecular Biology Reports, Frontiers in Oncology, RSC Advances, PLOS ONE, Journal of Biomolecular Structure & Dynamics, Journal of Molecular Graphics and Modelling, etc. She has edited and authored/co-authored 21 journal papers, 3 book chapters, and 15 abstracts. She is a Board of Studies member at her university. She is a life member of 'The Cytometry Society”-in India and 'All India Cell Biology Society”- in India.",institutionString:"Dr. D.Y. Patil Vidyapeeth, Pune",institution:{name:"Dr. D.Y. Patil Vidyapeeth, Pune",country:{name:"India"}}},{id:"354817",title:"Dr.",name:"Anubhab",middleName:null,surname:"Mukherjee",slug:"anubhab-mukherjee",fullName:"Anubhab Mukherjee",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0033Y0000365PbRQAU/ProfilePicture%202022-04-15%2005%3A11%3A18.480",biography:"A former member of Laboratory of Nanomedicine, Brigham and Women’s Hospital, Harvard University, Boston, USA, Dr. Anubhab Mukherjee is an ardent votary of science who strives to make an impact in the lives of those afflicted with cancer and other chronic/acute ailments. He completed his Ph.D. from CSIR-Indian Institute of Chemical Technology, Hyderabad, India, having been skilled with RNAi, liposomal drug delivery, preclinical cell and animal studies. He pursued post-doctoral research at College of Pharmacy, Health Science Center, Texas A & M University and was involved in another postdoctoral research at Department of Translational Neurosciences and Neurotherapeutics, John Wayne Cancer Institute, Santa Monica, California. In 2015, he worked in Harvard-MIT Health Sciences & Technology as a visiting scientist. He has substantial experience in nanotechnology-based formulation development and successfully served various Indian organizations to develop pharmaceuticals and nutraceutical products. He is an inventor in many US patents and an author in many peer-reviewed articles, book chapters and books published in various media of international repute. Dr. Mukherjee is currently serving as Principal Scientist, R&D at Esperer Onco Nutrition (EON) Pvt. Ltd. and heads the Hyderabad R&D center of the organization.",institutionString:"Esperer Onco Nutrition Pvt Ltd.",institution:null},{id:"319365",title:"Assistant Prof.",name:"Manash K.",middleName:null,surname:"Paul",slug:"manash-k.-paul",fullName:"Manash K. Paul",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/319365/images/system/319365.png",biography:"Manash K. Paul is a Principal Investigator and Scientist at the University of California Los Angeles. He has contributed significantly to the fields of stem cell biology, regenerative medicine, and lung cancer. His research focuses on various signaling processes involved in maintaining stem cell homeostasis during the injury-repair process, deciphering lung stem cell niche, pulmonary disease modeling, immuno-oncology, and drug discovery. He is currently investigating the role of extracellular vesicles in premalignant lung cell migration and detecting the metastatic phenotype of lung cancer via machine-learning-based analyses of exosomal signatures. Dr. Paul has published in more than fifty peer-reviewed international journals and is highly cited. He is the recipient of many awards, including the UCLA Vice Chancellor’s award, a senior member of the Institute of Electrical and Electronics Engineers (IEEE), and an editorial board member for several international journals.",institutionString:"University of California Los Angeles",institution:{name:"University of California Los Angeles",country:{name:"United States of America"}}},{id:"311457",title:"Dr.",name:"Júlia",middleName:null,surname:"Scherer Santos",slug:"julia-scherer-santos",fullName:"Júlia Scherer Santos",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/311457/images/system/311457.jpg",biography:"Dr. Júlia Scherer Santos works in the areas of cosmetology, nanotechnology, pharmaceutical technology, beauty, and aesthetics. Dr. Santos also has experience as a professor of graduate courses. Graduated in Pharmacy, specialization in Cosmetology and Cosmeceuticals applied to aesthetics, specialization in Aesthetic and Cosmetic Health, and a doctorate in Pharmaceutical Nanotechnology. Teaching experience in Pharmacy and Aesthetics and Cosmetics courses. She works mainly on the following subjects: nanotechnology, cosmetology, pharmaceutical technology, aesthetics.",institutionString:"Universidade Federal de Juiz de Fora",institution:{name:"Universidade Federal de Juiz de Fora",country:{name:"Brazil"}}},{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",slug:"abdulsamed-kukurt",fullName:"Abdulsamed Kükürt",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/219081/images/system/219081.png",biography:"Dr. Kükürt graduated from Uludağ University in Turkey. He started his academic career as a Research Assistant in the Department of Biochemistry at Kafkas University. In 2019, he completed his Ph.D. program in the Department of Biochemistry at the Institute of Health Sciences. He is currently working at the Department of Biochemistry, Kafkas University. He has 27 published research articles in academic journals, 11 book chapters, and 37 papers. He took part in 10 academic projects. He served as a reviewer for many articles. He still serves as a member of the review board in many academic journals. He is currently working on the protective activity of phenolic compounds in disorders associated with oxidative stress and inflammation.",institutionString:null,institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"178366",title:"Dr.",name:"Volkan",middleName:null,surname:"Gelen",slug:"volkan-gelen",fullName:"Volkan Gelen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178366/images/system/178366.jpg",biography:"Volkan Gelen is a Physiology specialist who received his veterinary degree from Kafkas University in 2011. Between 2011-2015, he worked as an assistant at Atatürk University, Faculty of Veterinary Medicine, Department of Physiology. In 2016, he joined Kafkas University, Faculty of Veterinary Medicine, Department of Physiology as an assistant professor. Dr. Gelen has been engaged in various academic activities at Kafkas University since 2016. There he completed 5 projects and has 3 ongoing projects. He has 60 articles published in scientific journals and 20 poster presentations in scientific congresses. His research interests include physiology, endocrine system, cancer, diabetes, cardiovascular system diseases, and isolated organ bath system studies.",institutionString:"Kafkas University",institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"418963",title:"Dr.",name:"Augustine Ododo",middleName:"Augustine",surname:"Osagie",slug:"augustine-ododo-osagie",fullName:"Augustine Ododo Osagie",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/418963/images/16900_n.jpg",biography:"Born into the family of Osagie, a prince of the Benin Kingdom. I am currently an academic in the Department of Medical Biochemistry, University of Benin. 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She is a fellow member of the Royal Society of Chemistry UK and the American Chemical Society of the United States.",institutionString:"King Saud University",institution:{name:"King Saud University",country:{name:"Saudi Arabia"}}},{id:"49848",title:"Dr.",name:"Wen-Long",middleName:null,surname:"Hu",slug:"wen-long-hu",fullName:"Wen-Long Hu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49848/images/system/49848.jpg",biography:"Wen-Long Hu is Chief of the Division of Acupuncture, Department of Chinese Medicine at Kaohsiung Chang Gung Memorial Hospital, as well as an adjunct associate professor at Fooyin University and Kaohsiung Medical University. Wen-Long is President of Taiwan Traditional Chinese Medicine Medical Association. He has 28 years of experience in clinical practice in laser acupuncture therapy and 34 years in acupuncture. He is an invited speaker for lectures and workshops in laser acupuncture at many symposiums held by medical associations. He owns the patent for herbal preparation and producing, and for the supercritical fluid-treated needle. Dr. Hu has published three books, 12 book chapters, and more than 30 papers in reputed journals, besides serving as an editorial board member of repute.",institutionString:"Kaohsiung Chang Gung Memorial Hospital",institution:{name:"Kaohsiung Chang Gung Memorial Hospital",country:{name:"Taiwan"}}},{id:"298472",title:"Prof.",name:"Andrey V.",middleName:null,surname:"Grechko",slug:"andrey-v.-grechko",fullName:"Andrey V. Grechko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/298472/images/system/298472.png",biography:"Andrey Vyacheslavovich Grechko, Ph.D., Professor, is a Corresponding Member of the Russian Academy of Sciences. He graduated from the Semashko Moscow Medical Institute (Semashko National Research Institute of Public Health) with a degree in Medicine (1998), the Clinical Department of Dermatovenerology (2000), and received a second higher education in Psychology (2009). Professor A.V. Grechko held the position of Сhief Physician of the Central Clinical Hospital in Moscow. He worked as a professor at the faculty and was engaged in scientific research at the Medical University. Starting in 2013, he has been the initiator of the creation of the Federal Scientific and Clinical Center for Intensive Care and Rehabilitology, Moscow, Russian Federation, where he also serves as Director since 2015. He has many years of experience in research and teaching in various fields of medicine, is an author/co-author of more than 200 scientific publications, 13 patents, 15 medical books/chapters, including Chapter in Book «Metabolomics», IntechOpen, 2020 «Metabolomic Discovery of Microbiota Dysfunction as the Cause of Pathology».",institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"199461",title:"Prof.",name:"Natalia V.",middleName:null,surname:"Beloborodova",slug:"natalia-v.-beloborodova",fullName:"Natalia V. Beloborodova",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/199461/images/system/199461.jpg",biography:'Natalia Vladimirovna Beloborodova was educated at the Pirogov Russian National Research Medical University, with a degree in pediatrics in 1980, a Ph.D. in 1987, and a specialization in Clinical Microbiology from First Moscow State Medical University in 2004. She has been a Professor since 1996. Currently, she is the Head of the Laboratory of Metabolism, a division of the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russian Federation. N.V. Beloborodova has many years of clinical experience in the field of intensive care and surgery. She studies infectious complications and sepsis. She initiated a series of interdisciplinary clinical and experimental studies based on the concept of integrating human metabolism and its microbiota. Her scientific achievements are widely known: she is the recipient of the Marie E. Coates Award \\"Best lecturer-scientist\\" Gustafsson Fund, Karolinska Institutes, Stockholm, Sweden, and the International Sepsis Forum Award, Pasteur Institute, Paris, France (2014), etc. Professor N.V. Beloborodova wrote 210 papers, five books, 10 chapters and has edited four books.',institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"354260",title:"Ph.D.",name:"Tércio Elyan",middleName:"Azevedo",surname:"Azevedo Martins",slug:"tercio-elyan-azevedo-martins",fullName:"Tércio Elyan Azevedo Martins",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/354260/images/16241_n.jpg",biography:"Graduated in Pharmacy from the Federal University of Ceará with the modality in Industrial Pharmacy, Specialist in Production and Control of Medicines from the University of São Paulo (USP), Master in Pharmaceuticals and Medicines from the University of São Paulo (USP) and Doctor of Science in the program of Pharmaceuticals and Medicines by the University of São Paulo. Professor at Universidade Paulista (UNIP) in the areas of chemistry, cosmetology and trichology. Assistant Coordinator of the Higher Course in Aesthetic and Cosmetic Technology at Universidade Paulista Campus Chácara Santo Antônio. Experience in the Pharmacy area, with emphasis on Pharmacotechnics, Pharmaceutical Technology, Research and Development of Cosmetics, acting mainly on topics such as cosmetology, antioxidant activity, aesthetics, photoprotection, cyclodextrin and thermal analysis.",institutionString:null,institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"334285",title:"Ph.D. Student",name:"Sameer",middleName:"Kumar",surname:"Jagirdar",slug:"sameer-jagirdar",fullName:"Sameer Jagirdar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334285/images/14691_n.jpg",biography:"I\\'m a graduate student at the center for biosystems science and engineering at the Indian Institute of Science, Bangalore, India. I am interested in studying host-pathogen interactions at the biomaterial interface.",institutionString:null,institution:{name:"Indian Institute of Science Bangalore",country:{name:"India"}}},{id:"329248",title:"Dr.",name:"Md. Faheem",middleName:null,surname:"Haider",slug:"md.-faheem-haider",fullName:"Md. Faheem Haider",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329248/images/system/329248.jpg",biography:"Dr. Md. Faheem Haider completed his BPharm in 2012 at Integral University, Lucknow, India. In 2014, he completed his MPharm with specialization in Pharmaceutics at Babasaheb Bhimrao Ambedkar University, Lucknow, India. He received his Ph.D. degree from Jamia Hamdard University, New Delhi, India, in 2018. He was selected for the GPAT six times and his best All India Rank was 34. Currently, he is an assistant professor at Integral University. Previously he was an assistant professor at IIMT University, Meerut, India. He has experience teaching DPharm, Pharm.D, BPharm, and MPharm students. He has more than five publications in reputed journals to his credit. Dr. Faheem’s research area is the development and characterization of nanoformulation for the delivery of drugs to various organs.",institutionString:"Integral University",institution:{name:"Integral University",country:{name:"India"}}},{id:"329795",title:"Dr.",name:"Mohd Aftab",middleName:"Aftab",surname:"Siddiqui",slug:"mohd-aftab-siddiqui",fullName:"Mohd Aftab Siddiqui",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329795/images/system/329795.png",biography:"Dr. Mohd Aftab Siddiqui is an assistant professor in the Faculty of Pharmacy, Integral University, Lucknow, India, where he obtained a Ph.D. in Pharmacology in 2020. He also obtained a BPharm and MPharm from the same university in 2013 and 2015, respectively. His area of research is the pharmacological screening of herbal drugs/natural products in liver cancer and cardiac diseases. He is a member of many professional bodies and has guided many MPharm and PharmD research projects. Dr. Siddiqui has many national and international publications and one German patent to his credit.",institutionString:"Integral University",institution:null},{id:"255360",title:"Dr.",name:"Usama",middleName:null,surname:"Ahmad",slug:"usama-ahmad",fullName:"Usama Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255360/images/system/255360.png",biography:"Dr. Usama Ahmad holds a specialization in Pharmaceutics from Amity University, Lucknow, India. He received his Ph.D. from Integral University, Lucknow, India, with his work titled ‘Development and evaluation of silymarin nanoformulation for hepatic carcinoma’. Currently, he is an Assistant Professor of Pharmaceutics, at the Faculty of Pharmacy, Integral University. He has been teaching PharmD, BPharm, and MPharm students and conducting research in the novel drug delivery domain. From 2013 to 2014 he worked on a research project funded by SERB-DST, Government of India. He has a rich publication record with more than twenty-four original journal articles, two edited books, four book chapters, and several scientific articles to his credit. He is a member of the American Association for Cancer Research, the International Association for the Study of Lung Cancer, and the British Society for Nanomedicine. Dr. Ahmad’s research focus is on the development of nanoformulations to facilitate the delivery of drugs.",institutionString:"Integral University",institution:{name:"Integral University",country:{name:"India"}}},{id:"333824",title:"Dr.",name:"Ahmad Farouk",middleName:null,surname:"Musa",slug:"ahmad-farouk-musa",fullName:"Ahmad Farouk Musa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333824/images/22684_n.jpg",biography:"Dato’ Dr Ahmad Farouk Musa\nMD, MMED (Surgery) (Mal), Fellowship in Cardiothoracic Surgery (Monash Health, Aust), Graduate Certificate in Higher Education (Aust), Academy of Medicine (Mal)\n\n\n\nDato’ Dr Ahmad Farouk Musa obtained his Doctor of Medicine from USM in 1992. He then obtained his Master of Medicine in Surgery from the same university in the year 2000 before subspecialising in Cardiothoracic Surgery at Institut Jantung Negara (IJN), Kuala Lumpur from 2002 until 2005. He then completed his Fellowship in Cardiothoracic Surgery at Monash Health, Melbourne, Australia in 2008. He has served in the Malaysian army as a Medical Officer with the rank of Captain upon completing his Internship before joining USM as a trainee lecturer. He is now serving as an academic and researcher at Monash University Malaysia. He is a life-member of the Malaysian Association of Thoracic & Cardiovascular Surgery (MATCVS) and a committee member of the MATCVS Database. He is also a life-member of the College of Surgeons, Academy of Medicine of Malaysia; a life-member of Malaysian Medical Association (MMA), and a life-member of Islamic Medical Association of Malaysia (IMAM). Recently he was appointed as an Interim Chairperson of Examination & Assessment Subcommittee of the UiTM-IJN Cardiothoracic Surgery Postgraduate Program. As an academic, he has published numerous research papers and book chapters. He has also been appointed to review many scientific manuscripts by established journals such as the British Medical Journal (BMJ). He has presented his research works at numerous local and international conferences such as the European Association for Cardiothoracic Surgery (EACTS) and the European Society of Cardiovascular Surgery (ESCVS), to name a few. He has also won many awards for his research presentations at meetings and conferences like the prestigious International Invention, Innovation & Technology Exhibition (ITEX); Design, Research and Innovation Exhibition, the National Conference on Medical Sciences and the Annual Scientific Meetings of the Malaysian Association for Thoracic and Cardiovascular Surgery. He was awarded the Darjah Setia Pangkuan Negeri (DSPN) by the Governor of Penang in July, 2015.",institutionString:null,institution:{name:"Monash University Malaysia",country:{name:"Malaysia"}}},{id:"30568",title:"Prof.",name:"Madhu",middleName:null,surname:"Khullar",slug:"madhu-khullar",fullName:"Madhu Khullar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/30568/images/system/30568.jpg",biography:"Dr. Madhu Khullar is a Professor of Experimental Medicine and Biotechnology at the Post Graduate Institute of Medical Education and Research, Chandigarh, India. She completed her Post Doctorate in hypertension research at the Henry Ford Hospital, Detroit, USA in 1985. She is an editor and reviewer of several international journals, and a fellow and member of several cardiovascular research societies. 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Fungal infectious illness prevalence and prognosis are determined by the exposure between fungi and host, host immunological state, fungal virulence, and early and accurate diagnosis and treatment. \r\nPatients with both congenital and acquired immunodeficiency are more likely to be infected with opportunistic mycosis. Fungal infectious disease outbreaks are common during the post- disaster rebuilding era, which is characterised by high population density, migration, and poor health and medical conditions.\r\nSystemic or local fungal infection is mainly associated with the fungi directly inhaled or inoculated in the environment during the disaster. The most common fungal infection pathways are human to human (anthropophilic), animal to human (zoophilic), and environment to human (soilophile). Diseases are common as a result of widespread exposure to pathogenic fungus dispersed into the environment. \r\nFungi that are both common and emerging are intertwined. In Southeast Asia, for example, Talaromyces marneffei is an important pathogenic thermally dimorphic fungus that causes systemic mycosis. Widespread fungal infections with complicated and variable clinical manifestations, such as Candida auris infection resistant to several antifungal medicines, Covid-19 associated with Trichoderma, and terbinafine resistant dermatophytosis in India, are among the most serious disorders. \r\nInappropriate local or systemic use of glucocorticoids, as well as their immunosuppressive effects, may lead to changes in fungal infection spectrum and clinical characteristics. Hematogenous candidiasis is a worrisome issue that affects people all over the world, particularly ICU patients. CARD9 deficiency and fungal infection have been major issues in recent years. Invasive aspergillosis is associated with a significant death rate. Special attention should be given to endemic fungal infections, identification of important clinical fungal infections advanced in yeasts, filamentous fungal infections, skin mycobiome and fungal genomes, and immunity to fungal infections.\r\nIn addition, endemic fungal diseases or uncommon fungal infections caused by Mucor irregularis, dermatophytosis, Malassezia, cryptococcosis, chromoblastomycosis, coccidiosis, blastomycosis, histoplasmosis, sporotrichosis, and other fungi, should be monitored. \r\nThis topic includes the research progress on the etiology and pathogenesis of fungal infections, new methods of isolation and identification, rapid detection, drug sensitivity testing, new antifungal drugs, schemes and case series reports. It will provide significant opportunities and support for scientists, clinical doctors, mycologists, antifungal drug researchers, public health practitioners, and epidemiologists from all over the world to share new research, ideas and solutions to promote the development and progress of medical mycology.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/4.jpg",keywords:"Emerging Fungal Pathogens, Invasive Infections, Epidemiology, Cell Membrane, Fungal Virulence, Diagnosis, Treatment"},{id:"5",title:"Parasitic Infectious Diseases",scope:"Parasitic diseases have evolved alongside their human hosts. In many cases, these diseases have adapted so well that they have developed efficient resilience methods in the human host and can live in the host for years. Others, particularly some blood parasites, can cause very acute diseases and are responsible for millions of deaths yearly. Many parasitic diseases are classified as neglected tropical diseases because they have received minimal funding over recent years and, in many cases, are under-reported despite the critical role they play in morbidity and mortality among human and animal hosts. The current topic, Parasitic Infectious Diseases, in the Infectious Diseases Series aims to publish studies on the systematics, epidemiology, molecular biology, genomics, pathogenesis, genetics, and clinical significance of parasitic diseases from blood borne to intestinal parasites as well as zoonotic parasites. We hope to cover all aspects of parasitic diseases to provide current and relevant research data on these very important diseases. In the current atmosphere of the Coronavirus pandemic, communities around the world, particularly those in different underdeveloped areas, are faced with the growing challenges of the high burden of parasitic diseases. At the same time, they are faced with the Covid-19 pandemic leading to what some authors have called potential syndemics that might worsen the outcome of such infections. Therefore, it is important to conduct studies that examine parasitic infections in the context of the coronavirus pandemic for the benefit of all communities to help foster more informed decisions for the betterment of human and animal health.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/5.jpg",keywords:"Blood Borne Parasites, Intestinal Parasites, Protozoa, Helminths, Arthropods, Water Born Parasites, Epidemiology, Molecular Biology, Systematics, Genomics, Proteomics, Ecology"},{id:"6",title:"Viral Infectious Diseases",scope:"The Viral Infectious Diseases Book Series aims to provide a comprehensive overview of recent research trends and discoveries in various viral infectious diseases emerging around the globe. The emergence of any viral disease is hard to anticipate, which often contributes to death. A viral disease can be defined as an infectious disease that has recently appeared within a population or exists in nature with the rapid expansion of incident or geographic range. This series will focus on various crucial factors related to emerging viral infectious diseases, including epidemiology, pathogenesis, host immune response, clinical manifestations, diagnosis, treatment, and clinical recommendations for managing viral infectious diseases, highlighting the recent issues with future directions for effective therapeutic strategies.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/6.jpg",keywords:"Novel Viruses, Virus Transmission, Virus Evolution, Molecular Virology, Control and Prevention, Virus-host Interaction"}],annualVolumeBook:{},thematicCollection:[{type:"book",id:"11672",title:"Chemokines Updates",subtitle:null,isOpenForSubmission:!0,hash:"c00855833476a514d37abf7c846e16e9",slug:null,bookSignature:"Prof. Murat Şentürk",coverURL:"https://cdn.intechopen.com/books/images_new/11672.jpg",editedByType:null,submissionDeadline:"May 6th 2022",editors:[{id:"14794",title:"Prof.",name:"Murat",middleName:null,surname:"Şentürk",slug:"murat-senturk",fullName:"Murat Şentürk",profilePictureURL:"https://mts.intechopen.com/storage/users/14794/images/system/14794.jpeg",biography:"Dr. Murat Şentürk obtained a baccalaureate degree in Chemistry in 2002, a master’s degree in Biochemistry in 2006, and a doctorate degree in Biochemistry in 2009 from Atatürk University, Turkey. Dr. Şentürk currently works as an professor of Biochemistry in the Department of Basic Pharmacy Sciences, Faculty of Pharmacy, Ağri Ibrahim Cecen University, Turkey. \nDr. Şentürk published over 120 scientific papers, reviews, and book chapters and presented several conferences to scientists. \nHis research interests span enzyme inhibitor or activator, protein expression, purification and characterization, drug design and synthesis, toxicology, and pharmacology. \nHis research work has focused on neurodegenerative diseases and cancer treatment. Dr. Şentürk serves as the editorial board member of several international journals.",institutionString:"Ağrı İbrahim Çeçen University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"Ağrı İbrahim Çeçen University",institutionURL:null,country:{name:"Turkey"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}],selectedSeries:{title:"Infectious Diseases",id:"6"},selectedSubseries:null},seriesLanding:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. This Biochemistry Series will address the current research on biomolecules and the emerging trends with great promise.",coverUrl:"https://cdn.intechopen.com/series/covers/11.jpg",latestPublicationDate:"June 29th, 2022",hasOnlineFirst:!0,numberOfOpenTopics:4,numberOfPublishedChapters:318,numberOfPublishedBooks:32,editor:{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},subseries:[{id:"14",title:"Cell and Molecular Biology",keywords:"Omics (Transcriptomics; Proteomics; Metabolomics), Molecular Biology, Cell Biology, Signal Transduction and Regulation, Cell Growth and Differentiation, Apoptosis, Necroptosis, Ferroptosis, Autophagy, Cell Cycle, Macromolecules and Complexes, Gene Expression",scope:"The Cell and Molecular Biology topic within the IntechOpen Biochemistry Series aims to rapidly publish contributions on all aspects of cell and molecular biology, including aspects related to biochemical and genetic research (not only in humans but all living beings). We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics include, but are not limited to: Advanced techniques of cellular and molecular biology (Molecular methodologies, imaging techniques, and bioinformatics); Biological activities at the molecular level; Biological processes of cell functions, cell division, senescence, maintenance, and cell death; Biomolecules interactions; Cancer; Cell biology; Chemical biology; Computational biology; Cytochemistry; Developmental biology; Disease mechanisms and therapeutics; DNA, and RNA metabolism; Gene functions, genetics, and genomics; Genetics; Immunology; Medical microbiology; Molecular biology; Molecular genetics; Molecular processes of cell and organelle dynamics; Neuroscience; Protein biosynthesis, degradation, and functions; Regulation of molecular interactions in a cell; Signalling networks and system biology; Structural biology; Virology and microbiology.",annualVolume:11410,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"79367",title:"Dr.",name:"Ana Isabel",middleName:null,surname:"Flores",fullName:"Ana Isabel Flores",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRpIOQA0/Profile_Picture_1632418099564",institutionString:null,institution:{name:"Hospital Universitario 12 De Octubre",institutionURL:null,country:{name:"Spain"}}},{id:"328234",title:"Ph.D.",name:"Christian",middleName:null,surname:"Palavecino",fullName:"Christian Palavecino",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000030DhEhQAK/Profile_Picture_1628835318625",institutionString:null,institution:{name:"Central University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"186585",title:"Dr.",name:"Francisco Javier",middleName:null,surname:"Martin-Romero",fullName:"Francisco Javier Martin-Romero",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSB3HQAW/Profile_Picture_1631258137641",institutionString:null,institution:{name:"University of Extremadura",institutionURL:null,country:{name:"Spain"}}}]},{id:"15",title:"Chemical Biology",keywords:"Phenolic Compounds, Essential Oils, Modification of Biomolecules, Glycobiology, Combinatorial Chemistry, Therapeutic peptides, Enzyme Inhibitors",scope:"Chemical biology spans the fields of chemistry and biology involving the application of biological and chemical molecules and techniques. In recent years, the application of chemistry to biological molecules has gained significant interest in medicinal and pharmacological studies. This topic will be devoted to understanding the interplay between biomolecules and chemical compounds, their structure and function, and their potential applications in related fields. Being a part of the biochemistry discipline, the ideas and concepts that have emerged from Chemical Biology have affected other related areas. This topic will closely deal with all emerging trends in this discipline.",annualVolume:11411,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null,editorialBoard:[{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",fullName:"Abdulsamed Kükürt",profilePictureURL:"https://mts.intechopen.com/storage/users/219081/images/system/219081.png",institutionString:null,institution:{name:"Kafkas University",institutionURL:null,country:{name:"Turkey"}}},{id:"241413",title:"Dr.",name:"Azhar",middleName:null,surname:"Rasul",fullName:"Azhar Rasul",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRT1oQAG/Profile_Picture_1635251978933",institutionString:null,institution:{name:"Government College University, Faisalabad",institutionURL:null,country:{name:"Pakistan"}}},{id:"178316",title:"Ph.D.",name:"Sergey",middleName:null,surname:"Sedykh",fullName:"Sergey Sedykh",profilePictureURL:"https://mts.intechopen.com/storage/users/178316/images/system/178316.jfif",institutionString:null,institution:{name:"Novosibirsk State University",institutionURL:null,country:{name:"Russia"}}}]},{id:"17",title:"Metabolism",keywords:"Biomolecules Metabolism, Energy Metabolism, Metabolic Pathways, Key Metabolic Enzymes, Metabolic Adaptation",scope:"Metabolism is frequently defined in biochemistry textbooks as the overall process that allows living systems to acquire and use the free energy they need for their vital functions or the chemical processes that occur within a living organism to maintain life. Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. Thus all studies on metabolism will be considered for publication.",annualVolume:11413,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",fullName:"Anca Pantea Stoian",profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"203824",title:"Dr.",name:"Attilio",middleName:null,surname:"Rigotti",fullName:"Attilio Rigotti",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institutionString:null,institution:{name:"Pontifical Catholic University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"300470",title:"Dr.",name:"Yanfei (Jacob)",middleName:null,surname:"Qi",fullName:"Yanfei (Jacob) Qi",profilePictureURL:"https://mts.intechopen.com/storage/users/300470/images/system/300470.jpg",institutionString:null,institution:{name:"Centenary Institute of Cancer Medicine and Cell Biology",institutionURL:null,country:{name:"Australia"}}}]},{id:"18",title:"Proteomics",keywords:"Mono- and Two-Dimensional Gel Electrophoresis (1-and 2-DE), Liquid Chromatography (LC), Mass Spectrometry/Tandem Mass Spectrometry (MS; MS/MS), Proteins",scope:"With the recognition that the human genome cannot provide answers to the etiology of a disorder, changes in the proteins expressed by a genome became a focus in research. Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. The Proteomics topic aims to attract contributions on all aspects of MS-based proteomics that, by pushing the boundaries of MS capabilities, may address biological problems that have not been resolved yet.",annualVolume:11414,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null,editorialBoard:[{id:"72288",title:"Dr.",name:"Arli Aditya",middleName:null,surname:"Parikesit",fullName:"Arli Aditya Parikesit",profilePictureURL:"https://mts.intechopen.com/storage/users/72288/images/system/72288.jpg",institutionString:null,institution:{name:"Indonesia International Institute for Life Sciences",institutionURL:null,country:{name:"Indonesia"}}},{id:"40928",title:"Dr.",name:"Cesar",middleName:null,surname:"Lopez-Camarillo",fullName:"Cesar Lopez-Camarillo",profilePictureURL:"https://mts.intechopen.com/storage/users/40928/images/3884_n.png",institutionString:null,institution:{name:"Universidad Autónoma de la Ciudad de México",institutionURL:null,country:{name:"Mexico"}}},{id:"81926",title:"Dr.",name:"Shymaa",middleName:null,surname:"Enany",fullName:"Shymaa Enany",profilePictureURL:"https://mts.intechopen.com/storage/users/81926/images/system/81926.png",institutionString:"Suez Canal University",institution:{name:"Suez Canal University",institutionURL:null,country:{name:"Egypt"}}}]}]}},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"chapter.detail",path:"/chapters/69147",hash:"",query:{},params:{id:"69147"},fullPath:"/chapters/69147",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()