Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\\n\\n
We wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
IntechOpen is proud to announce that 191 of our authors have made the Clarivate™ Highly Cited Researchers List for 2020, ranking them among the top 1% most-cited.
\n\n
Throughout the years, the list has named a total of 261 IntechOpen authors as Highly Cited. Of those researchers, 69 have been featured on the list multiple times.
\n\n\n\n
Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\n\n
We wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
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1. Introduction
In this chapter, we introduce a new methodology to measure the stress-train relation for ductile materials subjected to a continuum axial load; this loading was carried out by means of a universal testing machine. To obtain the stress-strain relation, materials were submitted to standardized compression tests, and to develop the technique, we used a laser beam impacting the cross section of the materials; the laser reflection was studied through Gaussian beam propagation equations and digital image processing. The scope of the present research is to determine a relation between the free propagation of a Gaussian beam and the stress-strain evolution of a ductile material.
Stress-strain diagrams are very important in understanding the behavior of materials under different loads [1]; these diagrams show the elastic, plastic, and rupture characteristics of materials. There are two methods to obtain these diagrams.
First, the invasive methods from which mechanics draw by doing physical tests, such as the test tube in which a standardized probe is placed on a testing machine; a continuum load is applied to it, and the resulting deformation is measured [2]. Other invasive methods are optical methods, which can determine residual stress, in-field displacements, and strain. Here, hole drilling is the most used technique. Originally developed in 1930 by Mathar [3], it is nowadays a standardized technique by the ASTM [4].
Second, nondestructive or noninvasive optical methods such as multiple laser displacement sensors which are applied to piping systems [5], stress measurements using crystal curvature technique during film growths [6], and another technique called deflectometry [7, 8], in which light passes through arrays that measure the curvature of objects; they are proposed as mirrors. The reflection caused by these objects is seen in a CCD camera, and the pattern is studied with standard phase shift techniques; most of the used objects are aspherical.
An image was defined as a two-dimensional function: fxy where x and y are plane coordinates and the amplitude f at any pair of coordinates xy is called the intensity referred as a gray level of the image at that point [9]. One of the first applications of digital images was in the newspaper industry through the introduction of the Bartlane cable picture transmission system in the early 1920s, where specialized printing equipment coded pictures for cable transmission and then reconstructed them at the receiving end [9]. However, the image processing method itself required storage and computational power; nevertheless, by this time, it was not possible to talk about processing since the development of the computer hadn’t arrived. One of the first works in this field was done by Harry Andrews [10], whom introduced techniques in order to work with images as matrixes; another book about the treatment of pictures was introduced by 1976 [11].
Digital image processing has been applied widely, in such cases as in control level for industries [12], which is based on the treatment of a special light shape generated by a laser, also measuring displacements in infrastructures by a matrix of points [13]. Some researchers around the application in engineering are evaluating the curvature of a pipeline using a parabolic function to determine its deformation [14], analyzing the location of cracks in reinforced concrete by monitoring the surface deformation with two cameras [15], strain measurements during film stretching process following the digital changes of the marker [16], and measuring the strain in time for standardized fatigue tests [17], among others.
In this chapter we introduce a novel methodology to measure the stress-strain behavior of ductile materials; this technique uses a laser beam focused on the cross section of a material probe which is under a compression test. We propose that the materials (1018 steel and aluminum alloy) will act as optical spherical mirrors. This is due to their surface transformation; the laser focuses in a surface which is completely flat, and it will deform as a reaction of the compression test. Therefore, the laser strikes this surface, and acting as a “mirror,” it will reflect and scatter the beam. Thus, the reflected laser area will increase as the deformation increases. This laser reflection is analyzed with Gaussian beam propagation equations by using digital image processing to measure each increasing area. This is the procedure we follow to obtain a relation between the laser-beam-free propagation and the strain, which we propose to be similar to the cross-section deformation of both materials. We show the accuracy, error, and sensitivity of the methodology, and we theoretically demonstrate how the laser beam spreads; the present research can be a suitable technique as it only uses a single laser beam for stress-strain characterization.
2. Theory
2.1 Gaussian beam analysis
The Gaussian beam is the simplest, the most known, and the most worked with, because its characteristics and evolution are well-known [18]. The amplitude function represented from Gaussian beams can be deduced by applying boundary conditions in the optical resonator, where the laser radiation is produced; this amplitude is described by
Exz=E0ω0ωz·exp−x2ωz2−kx22Rz−kz+ηz,E1
where E0 is the electric field amplitude, ω0 is the beam waist, ω(z) is how the beam propagates, k is the wave number (k=2π/λ), λ is the wavelength, R(z) is the curvature radius of the spherical waves, and ƞ(z) is the beam phase angle [19]. Laser beams are able to pass through different media; the light reflection occurs when it arrives to the boundary separating two media of different optical densities, and some of the energy is reflected back into the first medium [20]; taking this outset, if a laser beam strikes a mirror, the reflection can be studied as a Gaussian propagation. In our case, the metallic surface will be modeled as a convex mirror. As it is well-known, there is a relation between the focal length and the curvature radius of a mirror. Using this relation the phase of the transmitted wave is altered to
φxz=2ηz−kx2z1+z02z2+kx2f,E2
where z0 is the initial Rayleigh distance and f is the focal length of the mirror [21]. To study the propagation through a lens phenomenon, the Gaussian propagation equations are established in which ω0 and z0 turns into ω1 and z1, respectively, after a distance f and they are calculated by
ω1=ω01+z02f2,E3
z1=f1+f2z02.E4
This pair of equations involves how Gaussian beam propagates [21], so in order to calculate the new beam waist in the propagation axis, we have
ωzp=ω11+zp2z12,E5
where ω(zp) is the new beam waist at zp which is the propagation distance.
The goal of this research is to reach a general relation between the strains caused in any material by measuring with one laser beam, its reflection and relating it to a focal length transformation. As we implicate the focal length, we need these Gaussian propagation equations to calculate the changes in the focal length during the compression test. Substituting Eqs. (3), (4) in (5) it can be deduced:
zp2z04·x2+x1−ωzp2ω02−z02=0.E6
The parameter zp is calculated doing DIP, taking each area increment per second during the compression test. Once the result from Eq. (6) is obtained, the variation of the focal length is determined applying
ξ=ff−fifi,E7
where ff is the final focal length and fi is the initial focal length; following this procedure, we obtained a dimensionless variable.
2.2 Compression tests
Mechanical tests are used to know the mechanical properties of materials; a compression test enables the user to understand the behavior of a material under a continuum axial load; from this test it is possible to obtain the stress-strain diagram of any material [2]. In this chapter we worked with samples of steel with dimensions of 2.5 × 2.5 × 2.2 cm and aluminum samples of 1 × 1 × 0.9 cm according to the small-type standard dimensions [22]; all samples undergo into compression test according to ASTM E-9 [22]. The tests were performed with a speed ratio of 0.2 cm/s up to 90 MPa for steel and up to 20 MPa for aluminum. Since we are working on the elastic part of the diagram, therefore we can apply Hooke’s law:
σ=E·ε,E8
where σ is the engineering stress, E is the Young’s module of the material (200 and 70 GPa) for steel and aluminum, respectively, and ε is the engineering strain. We propose that the experimental stress is going to behave similar to the Hooke’s law; thus, we relate Eq. (8) to the focal length by
σ=E·K·ξ,E9
where K is a material coefficient proposed in this chapter and ξ is the dimensionless value obtained in Eq. (7). The coefficient K is obtained from the relation between the slopes of both graphs of interest: stress-strain diagram and DIP plot.
2.3 Theoretical analysis
In this research, we used a He-Ne laser with specific parameters such as initial intensity, beam waist, and Rayleigh distance that are shown in its handbook [23].
In Figure 1 we plot Eqs. (1) and (2) substituting the results from Eq. (7), the initial parameters of our laser and propagating formally this laser beam. In this figure, we can observe that when the focal length increases, the beam waist has also an increase, in this theoretical demonstration; we propose that these increments are proportional as we assume that ε ≈ f.
Figure 1.
Gaussian propagation: intensity profile.
By using Fresnel diffraction and the treatment of lens transmission [24], we have
Replacing Eqs. (11) and (12) into Eq. (10), expanding formally and changing coordinates, we obtain
Uρ=iπaλfexpik2f+b24a·ρ2,E13
where
a=1−ik2f,E14
b=ikf,E15
According to the present research, the initial area of the reflected laser was A ∼ 0.009 m2.
3. Methodology
As we established before, we use two ductile materials: steel and aluminum; in total, seven samples were hand-sanded and polished in the same manner to mirror grade in the laser-impact section, and they were placed in the machine perpendicular to the piston to begin the compression test. A diagram of this method is shown schematically in Figure 2a. The output of a He-Ne laser (L), with a wavelength λ = 632 nm and a power of 1 mW, is placed 15 cm from the sample (Sa) in order to irradiate the polished face, and then, the reflected beam impacts a screen (Sc) which is placed 10 cm beside the laser beam and parallel to the sample. The material is first completely flat, with no stress, and as it is compressed with the universal machine (M), the size of the cross section will decrease as a reaction (Figure 2b). During the tests, the deformation rate was 0.2 cm/s with duration of 5 min approximately, and while they were taking place, the reflected light was recorded with a video camera (Vc) which is placed in front and parallel to the screen aside the sample. All tests were done at room temperature, and samples were compressed around 2 mm.
Figure 2.
Experimental setup: (a) material with no strain; (b) the strained material will scatter light.
When we finish the mechanical test, a post-processing is carried out:
First, we need to transfer the video from the video card to the computer.
Then, we use the free software called Video to JPG converter; it helps us to divide the entire video into each frame. The software enabled us to turn our videos with an average of 54 frames per second.
A program is written in Matlab® for digital image processing.
To do the image processing, we used some Matlab® toolbox functions, mention, and describe them:
imread: this function loads the image as a matrix.
rgb2grey: this code turns the colored image into a gray scale level.
im2bw: this is necessary to convert the image matrix into a binary code.
bwarea: we call this function at the end of the code to calculate by binary code the total area of the reflected laser beam.
Along Figure 3, we can observe how the code works: in Figure 3a it is seen how imread works; when we call it, the image is loaded; for Figure 3b we can observe how rgb2grey converts the colored image into a grayscale; in Figure 3c we called im2bw to do a binary code of the image. At this step we can apply the function bwarea to know the area of this “circle.” We can observe in Figure 3d and e how the beam diameter increases, for a ti = 0 s and tf = Δt s. By following the methodology described and using Eq. (6), we can obtain the change in the focal length and relate it to the deformation in the material.
Figure 3.
Image processing: (a) how the image is loaded; (b) grayscale image; (c) binary image; (d) initial beam diameter; (e) beam diameter at t = ti + Δt.
The code was written to repeat this process iteratively for every image. We propose that the calculated area is the parameter ω(zp). Therefore Eq. (6) is used to calculate the focal length. We know that as a result of doing a mechanical test, we can obtain a stress-strain diagram; it is calculated through strain gages and special software incorporated to the machine. At the end of the iterative process, we plot the focal length differences following Eq. (7).
4. Results
Along this chapter, we have mentioned that we prepared four steel samples and three aluminum probes, to test them under standardized compression test; for each one we obtained two graphs of interest, the stress-strain diagram and the DIP plot; Figure 4 shows these two graphs of interest. Figures 4–8 correspond to steel samples.
Figure 4.
Stress-strain diagrams: (a) obtained from universal machine, (b) experimentally from optical treatment.
In Figure 4a we show the stress-strain diagram obtained from the software of the machine; in Figure 4b we can observe the related stress-focal length diagram obtained by following the experimental procedure and using Eq. (9). In the graphs we can observe a linear behavior. In section 2.2, we propose an equation related to Hooke’s law, where the K value is calculated using the slopes of each graph and Δε is taken from 0.1 to 0.3%ε. Therefore the calculated slope of the real stress-strain diagram is 0.00351 and for the experimental data is 0.001401; K coefficient between them is 2.5.
In Figure 5 we show the first steel sample comparison between the real strain (Real Def.) and the experimental related-strain (Exp. Def.); both are represented in % as strain has no dimensions, and also some statistical results are shown in Table 1. From here, the following graphs are going to be presented the same way.
Figure 5.
Comparison between stress-strain diagrams for steel’s sample 1.
First sample
K factor
2.5
Young’s modulus E
188 ± 12 GPa
% difference from 200 GPa
11%
Standard deviation
0.011
Table 1.
Statistical result for steel’s sample 1 during the compression tests and Gaussian beam analysis.
We repeat this procedure for the next three samples, obtaining K factor and comparing the real stress-strain diagram with the experimental plot and showing the statistical results for each one.
For the second test, we can see in Table 2 that K factor remains in a value of 2.5; in this test we obtained an accurate result of 88% as compared to the real graph. In the third and fourth tests, we see in Tables 3 and 4 that the value of the proposed K factor decreases to 2.4, but we obtained the same approach in reproducing the stress-strain diagram.
Second sample
K factor
2.5
Young’s modulus E
188 ± 12 GPa
% difference from 200 GPa
11%
Standard deviation
0.010
Table 2.
Statistical results for steel’s sample 2 during the compression tests and Gaussian beam analysis.
Third sample
K factor
2.4
Young’s modulus E
188 ± 12 GPa
% difference from 200 GPa
11%
Standard deviation
0.012
Table 3.
Statistical results for steel’s sample 3 during the compression tests and Gaussian beam analysis.
Fourth sample
K factor
2.4
Young’s modulus E
187 ± 13 GPa
% difference from 200 GPa
11%
Standard deviation
0.013
Table 4.
Statistical results for sample 4 during the compression tests and Gaussian beam analysis.
In Figures 5 and 7, the behavior of the experimental graph is above the real stress-strain diagram; for Figures 6 and 8, the behavior has an intersection—it first starts below then crosses above it. We propose that the behavior of the area increase is due to the material surface, as it was hand-sanded and polished; light is not reflecting equally in every sample of material.
Figure 6.
Comparison between stress-strain diagrams for steel’s sample 2.
Figure 7.
Comparison between stress-strain diagrams for steel’s sample 3.
Figure 8.
Comparison between stress-strain diagrams for steel’s sample 4.
In Table 5 we summarize the accuracy and mean error for this four strain measurements; we can observe that the mean accuracy of our methodology is 89%.
Sample
Accuracy (%)
K
1
89
2.5
2
89
2.5
3
89
2.4
4
89
2.4
Table 5.
Accuracy and error of the four tests.
With this novel technique, taking the focal length as a parameter for measuring the stress-strain relation of a material, we proved an 89% effectiveness following standardized compression tests using steel samples; also we obtained a K value for this material of 2.5, which establishes the relation between the slopes of the real and the experimental graphs [25].
In this section, we present the statistical results and stress-strain diagrams obtained from aluminum samples. We are following the same process by comparing the DIP graph with the real stress-strain obtained from the universal machine software. Figure 9 and Table 6 show the results for the first aluminum sample; with this material we obtained a K value of 4.52 and an approach of 90%.
Figure 9.
Comparison between stress-strain diagrams for aluminum’s sample 1.
First sample
K factor
4.52
Young’s modulus E
63 ± 7 GPa
% difference from 70 GPa
10%
Standard deviation
0.015
Table 6.
Statistical results for aluminum’s sample 1 during the compression tests and Gaussian beam analysis.
Using aluminum samples, we obtained similar approximations to the steel ones. In Table 7 we can observe a K value of 4.54 and a slightly less approach than sample 1, obtaining 89%. In Table 8 we observe a K value of 4.5 and an approach of 88%.
Second sample
K factor
4.54
Young’s modulus E
62 ± 8 GPa
% difference from 70 GPa
11%
Standard deviation
0.013
Table 7.
Statistical results for aluminum’s sample 2 during the compression tests and Gaussian beam analysis.
Third sample
K factor
4.5
Young’s modulus E
61 ± 9 GPa
% difference from 70 GPa
12%
Standard deviation
0.018
Table 8.
Statistical results for aluminum’s sample 3 during the compression tests and Gaussian beam analysis.
By comparing Figures 9–11 to steel results, we can see that aluminum alloys behave differently than steel ones. In these figures we can appreciate that the experimental graph goes above the real diagram at the same point (0.08%). In Figures 10 and 11, the experimental result goes first below, then above the real stress-strain diagram. These differences, such as steel ones, are due to the sample surface; during the process of making mirror-grade samples, we can accidentally cause nonuniform surfaces, and thus light reflection is not always the same.
Figure 10.
Comparison between stress-strain diagrams for aluminum’s sample 2.
Figure 11.
Comparison between stress-strain diagrams for aluminum’s sample 3.
In Table 9 we summarize the accuracy and mean error for these three measurements; it is seen that the mean accuracy of our method is 89%.
Probe
Accuracy (%)
K
1
90
4.54
2
89
4.52
3
88
4.5
Table 9.
Accuracy and error of the three tests.
With this developed technique, taking the focal length as a parameter for measuring the stress-strain relation of a material, we proved an 89% effectiveness following standardized compression tests using aluminum samples; we also obtained a K value for this material of 4.5, which stablishes the relation between the slopes of the real and the experimental graphs [26].
Summarizing these tests, steel and aluminum, we observed that the present methodology can measure the stress-strain relation of a ductile material with an average error of 11%. We established that by recording the video, we obtained 54 images in average; therefore, we calculate the mean differences between measurement in a 10-s time interval, thus to obtain the sensitivity of this methodology, which resulted to 27 microdeformations.
5. Conclusion
The stress-strain relation of two ductile materials under standardized compression test was measured using one laser beam, its reflection, and digital image processing treatment; we obtained 89% of accuracy and a relation of 27 microdeformation. Also it was demonstrated that the diameter of the laser reflection has an increment according to the increase in the focal length; we also showed following Fresnel diffraction and the transmission through a lens that the comparison between the reflected area and the experimental results is congruent.
Acknowledgments
Alonso Saldaña Heredia wants to thank CONACYT for the grant no. 360140.
Conflict of interest
The authors declare no conflict of interest for this chapter.
\n',keywords:"compression test, stress-strain, Gaussian beam, Fourier analysis, image processing",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/68748.pdf",chapterXML:"https://mts.intechopen.com/source/xml/68748.xml",downloadPdfUrl:"/chapter/pdf-download/68748",previewPdfUrl:"/chapter/pdf-preview/68748",totalDownloads:625,totalViews:0,totalCrossrefCites:0,totalDimensionsCites:1,totalAltmetricsMentions:0,introChapter:null,impactScore:0,impactScorePercentile:40,impactScoreQuartile:2,hasAltmetrics:0,dateSubmitted:"March 23rd 2019",dateReviewed:"July 19th 2019",datePrePublished:"February 14th 2020",datePublished:"May 13th 2020",dateFinished:"August 23rd 2019",readingETA:"0",abstract:"Digital image processing is a useful tool that improves pictorial information for human interpretation and is mainly used for storage, transmission, and representation of different data. In this chapter, we want to introduce an optical technique which couples physical analysis with image processing for a measurement system. Optical methods were used to obtain the stress-strain relation by different invasive and noninvasive methods. This chapter talks about a novel noninvasive methodology to measure stress-strain evolution; this technique is based upon a single laser beam reflected on the cross section of ductile materials (steel and aluminum) while they are under a compression load. The way we measure one laser beam is by using the Gaussian beam propagation equations; we propose that the reflection area of the laser is going to change as the material surface area is compressed and we analyze these differences by using digital image processing. With this technique we are able to construct a stress-strain diagram.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/68748",risUrl:"/chapter/ris/68748",book:{id:"9239",slug:"digital-imaging"},signatures:"Alonso Saldaña-Heredia, Pedro Antonio Márquez-Aguilar, Álvaro Zamudio Lara and Arturo Molina-Ocampo",authors:[{id:"51029",title:"Dr.",name:"Pedro Antonio",middleName:null,surname:"Marquez Aguilar",fullName:"Pedro Antonio Marquez Aguilar",slug:"pedro-antonio-marquez-aguilar",email:"pmarquez@uaem.mx",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"Universidad Autónoma del Estado de Morelos",institutionURL:null,country:{name:"Mexico"}}},{id:"299407",title:"Dr.",name:"Alonso",middleName:null,surname:"Saldaña Heredia",fullName:"Alonso Saldaña Heredia",slug:"alonso-saldana-heredia",email:"alonso.saldana@uaem.mx",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"Universidad Autónoma del Estado de Morelos",institutionURL:null,country:{name:"Mexico"}}},{id:"299409",title:"Dr.",name:"Álvaro",middleName:null,surname:"Zamudio Lara",fullName:"Álvaro Zamudio Lara",slug:"alvaro-zamudio-lara",email:"azamudio@uaem.mx",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"Universidad Autónoma del Estado de Morelos",institutionURL:null,country:{name:"Mexico"}}},{id:"306535",title:"Dr.",name:"Arturo",middleName:null,surname:"Molina Ocampo",fullName:"Arturo Molina Ocampo",slug:"arturo-molina-ocampo",email:"arturo_molina@uaem.mx",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"Universidad Autónoma del Estado de Morelos",institutionURL:null,country:{name:"Mexico"}}}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Theory",level:"1"},{id:"sec_2_2",title:"2.1 Gaussian beam analysis",level:"2"},{id:"sec_3_2",title:"2.2 Compression tests",level:"2"},{id:"sec_4_2",title:"2.3 Theoretical analysis",level:"2"},{id:"sec_6",title:"3. Methodology",level:"1"},{id:"sec_7",title:"4. Results",level:"1"},{id:"sec_8",title:"5. Conclusion",level:"1"},{id:"sec_9",title:"Acknowledgments",level:"1"},{id:"sec_12",title:"Conflict of interest",level:"1"}],chapterReferences:[{id:"B1",body:'Figliola R, Beasley F. Theory and Design for Mechanical Measurements. 5th ed. USA: John Wiley & Sons; 2011. 605 p. ISBN: 978-0-470-54741-0'},{id:"B2",body:'Gere J, Goodno B. Mecánica de Materiales. 8th ed. Cengage Learning: Mexico; 2016. 1125 p. ISBN: 978-1-111-57773-5'},{id:"B3",body:'Mathar J. Determination of initial stresses by measuring the deformation around drilled holes. Transactions of the ASME. 1934;56(4):249-254'},{id:"B4",body:'ASTM. Determining residual stresses by the hole-drilling strain gage method. In: ASTM Standard Test Method E837-08. West Conshohocken, PA: American Society for Testing and Materials; 2008'},{id:"B5",body:'Maekawa A et al. Development of noncontact measurement methods using multiple laser displacement sensors for bending and torsional vibration stresses in piping systems. International Journal of Pressure Vessels and Piping. 2015;137:38-45. DOI: 10.1016/j.ijpvp.2015.05.002'},{id:"B6",body:'Premper J et al. In situ stress measurements during pulsed laser deposition of BaTiO3 and SrTiO3 atomic layers on Pt(0 0 1). Applied Surface Science. 2015;335:44-49'},{id:"B7",body:'Liu Y et al. Fast and accurate deflectometry with crossed fringes. Advanced Optical Technologies. 2014;3(4):441-445'},{id:"B8",body:'Huang E et al. Measuring aspheric surfaces with reflection deflectometry. SPIE Newsroom. 2013. 3 p. DOI: 10.1117/2.1201309.005087. Available from: https://www.researchgate.net/publication/275085156_Measuring_aspheric_surfaces_with_reflection_deflectometry/link/554d1c9f0cf21ed2135f5dca/download'},{id:"B9",body:'González R, Woods R. Digital Image Processing. 2nd ed. New Jersey: Prentice Hall; 2002. 793 p. ISBN: 978-0-201-18075-6'},{id:"B10",body:'Andrews HC. Computer Techniques in Image Processing. NY: Academic Press; 1970'},{id:"B11",body:'Rosenfeld A, Kak CA. Digital Picture Processing. NY: Academic Press; 1982'},{id:"B12",body:'Li C et al. Digital image processing technology applied in level measurement and control system. Procedia Engineering. 2011;24:226-231'},{id:"B13",body:'Kim S-W, Kim N-S. Multi-point displacement response measurement of civil infrastructures using digital image processing. Procedia Engineering. 2011;14:195-203'},{id:"B14",body:'Iwamoto T, Kanie S. Evaluation of bending behavior of flexible pipe using digital image processing. 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Washington DC: Optical Society of America; 1988. 846 p. ISBN: 155-752-0631'},{id:"B21",body:'Saleh AEB, Teich MC. Fundamentals of Photonics. 1st ed. New York: John Wiley & Sons; 1991. 982 p. ISBN: 978-0-585-32147-9'},{id:"B22",body:'ASTM E-9, ICS Number Code 77.040.10 (Mechanical testing of metals). DOI: 10.1520/E0009-09'},{id:"B23",body:'JDSU Self-Contained Helium-Neon Laser Systems 1500 series Specification Sheet. JDS Uniphase Corporation 10138846 005 0512 SCHNL1500.DS.CL.AE. 2012'},{id:"B24",body:'Goodman JW. Introduction to Fourier Optics. 3rd ed. United States: Roberts & Company; 2005. 509 p. ISBN: 0-9747077-2-4'},{id:"B25",body:'Saldaña HA, Márquez APA, Molina OA. Laser-beam reflection for steel stress-strain characterization. Measurement. 2018;113:92-98'},{id:"B26",body:'Saldaña HA, Márquez APA, Molina OA. Aluminum strain measurement by beam propagation. In: Martínez-García A et al., editors. Emerging Challenges for Experimental Mechanics in Energy and Environmental Applications. Proceedings of the 5th International Symposium on Experimental Mechanics and 9th Symposium on Optics in Industry (ISEM-SOI), Conference Proceedings of the Society for Experimental Mechanics Series. 2015. DOI: 10.1007/978-3-319-28513-9_2'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Alonso Saldaña-Heredia",address:"aheredia@upmh.edu.mx",affiliation:'
Metropolitan Polytechnic University of Hidalgo—UPMH, Mexico
'},{corresp:null,contributorFullName:"Pedro Antonio Márquez-Aguilar",address:null,affiliation:'
Research Center on Engineering and Applied Sciences—IICBA, Autonomous University of Morelos State, Mexico
Research Center on Engineering and Applied Sciences—IICBA, Autonomous University of Morelos State, Mexico
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1. Introduction
The protein system in bovine milk is made up of two main protein families: casein (insoluble) and whey proteins (soluble). Casein is the major portion 80% of total protein content weight by weight (w/w) and is easy to separate from non-fat milk through isoelectric precipitation (by adding acid or producing it in situ) or rennet-driven coagulation, and the leftover is whey. Whey proteins consists of spherical molecules as well as amino acids either acidic/basic or hydrophilic/hydrophobic in composition of their polypeptide chains that are evenly distributed to form a helical shape [1]. Profiling of whey protein including it chemical and physiological properties like β-lactoglobulin (β-LG), a-lactalbumin (α-LA), immunoglobulins (IG), bovine serum albumin (BSA), bovine lactoferrin (BLF), and lactoperoxidase (LP) along with other constituents are all contained in whey proteins [2]. Whey protein concentrations varies depending on its type (acidic or sweet), milk source (bovine, caprine, or ovine), phase of the year, the kind of feedstuff, lactation phase, and productivity.
2. Components and types of whey proteins
Acid whey, which has a pH of 5.1 or less, is made by acidifying milk directly, as is used in the production of cottage cheese. After rennet-coagulation, sweet whey with a pH of 5.6 or higher is produced, as it is used in most cheese-making processes around the world [3]. Whey protein (protein not precipitated by acid or rennet) accounts for about 0.6 to 0.7 percent of total milk content and accounts for about 20% of overall milk proteins. Whey proteins are high in nutrients that are beneficial to wellbeing of humans. α-lactalbumin, β-lactoglobulin, lactoferin, lactoperoxidase, immunoglobulins, and glycomacropetide are among the proteins present in it [4]. Percentage of each component of whey protein is mentioned in Table 1.
Approximate concentration of proteins in whey in different species.
The development of processing techniques, particularly those based on selectively permeable membranes, has allowed a range of whey protein constituents to emerge as common food additives in the last two decades. The membrane based processing techniques results in ultrafiltration (UF) to concentrate proteins and diafiltration (DF) to eliminate most lactose, minerals and low molecular weight components and hence producing versatile whey products with distinct qualitative and quantitative profiles of proteins, minerals, lipids, sugars and whey protein concentrate (WPC). There are WPC that produce 35, 50, 65 and 80% (w/w) protein, subject to their concentration. When the protein content reaches 90% (w/w), a whey protein isolate (WPI) is made, that is a high-grade and pure protein concentrate. When added to foods, each of these compounds function as carriers for the stimulation of a variety of biological characters. When whey is heated, α-LA denatures quickly, allowing the fraction to be divided by precipitation [14]. Whey protein hydrolysate (WPH) is the “predigested” type of whey protein since it has already passed through partial hydrolysis, which is needed for the body to consume protein. WPH is easier to absorb than the other two types of whey protein [15, 16, 17]. Flow sheet of all types of whey proteins is mentioned under Figure 1.
Figure 1.
Types of whey proteins; this classification is based on protein processing and refining [18, 19].
3. Physiological and biological roles of whey proteins
Whey protein is high in bioactive peptides, which can help with chronic disease control by nutrition. The conventional and evolving implications of whey proteins are elaborated in below para [20, 21].
Whey proteins and their constituents have been found to have a variety of health advantages. In a study, bovine whey proteins showed positive impacts on the lipid profile in serum and liver, including overall lipid and triglyceride alteration and reduction [22]. Enzymatic breakdown (natural digestion in the GI tract, enzyme mediated hydrolysis, milk fermentation) of whey proteins produces antihypertensive peptides (ACE-I) [23]. Whey proteins derivatives like short chain and peptides resistant to water have been shown in studies to reduce blood pressure and stress hypertension by increasing ACE inhibitory action [24, 25]. Whey proteins are a predecessor or foundation of glutathione (GSH) that performs oxidation against reactive oxygen species (ROS), responsible for tissue harm, especially in the central nervous system’s neurons and glial cells [26]. Whey proteins are unusual in their capacity to increase glutathione (GSH) levels in different tissues that optimizes the functionality and structure of the immune system [27]. GSH defends cells from free radical destruction, contaminants, chemicals, infection, and UV exposure as part of antioxidant defense mechanism of body [28]. GSH levels are usually low in people who have cancer, HIV, persistent fatigue syndrome, or other immune-suppressing diseases [29]. GSH levels drop with age, and it’s thought to play a role in diseases like Alzheimer’s, cataracts, Parkinson’s, and arteriosclerosis. Whey proteins provide a number of health benefits, including improving the acquired immune system. The most active fractions were whey protein extracts from β-lactoglobulin and α-lactalbumin, which had an additive impact on neutrophils, making them more sensitive to a subsequent stimulus [30]. Supplementing athletes with whey protein during rigorous endurance training can help them boost the immunity in between and afterward of workout and physical activity [29, 30]. In infants, an improved immune response may aid in the prevention of bacteriological and pathological syndromes, as well as illnesses including gastroenteritis. Thus, including whey proteins in one’s diet can benefit people of all ages, not just those with a weakened immune system [31]. Whey protein has been shown to prohibit the progression of pathogenic bacteria, suggesting that it may be used to regulate the development and reinfection of E. coli (O157:H7), Listeria monocytogenes, and Salmonella typhimurium in ready to eat meat by using WPI as a defensive film covering ingredient [32, 33, 34, 35]. Rises in the levels of alanine in plasma and aspartate aminotransferase activities, production of lactate dehydrogenase, and bilirubin concentration that refers to hepatitis indicators, as well as hyaluronic acid concentration which is fibrosis marker can be suppressed by a whey protein-rich diet [36, 37].
The active ingredient of whey protein found to have a vital role in growth and development of bones as well as a possible healing impact on osteoporosis by stimulating osteoblasts [38, 39]. The biochemical role of peptides in whey protein is as food additives is to improve calcium absorption (by preventing calcium phosphate formation) and avoid bone disorders [40]. Branched-chain amino acids (BCAAs) are well-known in whey proteins. While the need for BCAAs rises with endurance activity, whey protein may be used to supplement these BCAAs during the healing process to boost protein synthesis and muscle development [41]. Since both whey and skeletal muscle almost have identical amino acid profiling, it is highly effective to speedup muscle protein synthesis [42]. As a result, whey protein, by its necessary amino acids, aids in the production of skeletal muscle protein and the avoidance of sarcopenia (muscle wasting) after strenuous exercise [43, 44]. Current researches depicts that whey proteins may help athletes with resistance training boost their lean body mass and efficiency [45]. Increased brain tryptophan and serotonin activities boost cognitive function in stress-prone subjects because of efflux of whey protein in α-lactalbumin [46]. In milk, glycomacropeptides (GMPs) and whey protein concentrate may help probiotic bacteria like bifidobacterium lactis development. Gut wellbeing has been seen to be improved by a variety of probiotic bacteria [47]. Cancer prevention is essential. Whey protein in the diet can lower serum C-peptide levels and duodenal SREBP-1c mRNA profusion, as well as lessen the risk of duodenal tumors [48, 49]. Growth stimulator established in whey proteins showed positive impacts on various mammalian cells of the culture media. These growth stimulators work by suppressing protein degeneration and enhancing synthesis of protein and DNA inside the cells. As a result, whey protein can aid in tissue regeneration as well as the prevention of psoriasis and ulcers [50]. Incorporating whey protein concentrates and glycomacropeptides (GMPs) into the diet may increase satiety and reduce food consumption. GMP that activates cholecystokinin (CCK), which is a hormone to suppress hunger, is shown to have variety of important roles in gastrointestinal activity, including food intake control [51]. Various other proteins, in the patients suffering from type 2 diabetes, established to be overtaken by whey proteins for the improvement of postprandial lipemia, when taken as a complement to a fat-rich diet, likely due to the development of less chylomicrons or improved clearance of chylomicrons [25, 52] as shown in Figure 2.
Figure 2.
Biological roles of whey proteins summarized from different literature [53, 54, 55, 56, 57, 58, 59, 60].
4. Inflammatory cytokines in inflammatory process
Cytokines are tiny secreted proteins (<40 kDa) that virtually every cell produces to control and affect immune response [20]. The discharge of pro-inflammatory cytokines causes immune cell initiation and development, along with the discharge of additional cytokines [61]. When the word “cytokine storm” first appeared, it was used to describe inflammation as a rapid immediate discharge of cytokines to activate an inflammatory mechanism [62]. Current work of scientists suggests that in every immune reaction, the simultaneous release of pro- and anti-inflammatory cytokines is needed [63]. Interleukins, chemokines, and growth factors are only some of the terms used to describe cytokines [64]. Super families of cytokines exist, which do not actually describe common genes but rather related structures [64]. Furthermore, the same cytokine may be generated by various cell populations. Cytokines have pleiotropic effects and their effects are dependent on the cell they are targeting [65]. Furthermore, various cytokines may have the same impact, making them redundant. However, they could have a synergistic influence. Finally, they can initiate signaling cascades, allowing even tiny amounts of protein to have catastrophic consequences [66].
5. Whey proteins leads to activation and production of pro-inflammatory cytokines
As cellular antioxidants struggle to keep up with ROS, the organism suffers from oxidative stress [67]. Inflammation causes damage to tissue by releasing free radicals from macrophages and neutrophils [68]. By transporting iron, whey proteins are essential for maintaining oxidative stress [69]. They produce the cytotoxic protection mechanism of neutrophils as well as free radicals [70, 71]. Whey proteins are involved in the preservation of inflammation through reducing lipid peroxidation and oxygen radicals via the production of antioxidant glutathione. Inflammatory cytokines are generated in large part by whey proteins. Whey proteins supplementation restored a high degree of IL-1β and TNF-α. IL-1β and TNF-α influenced the expression of chemokines and the adhesion of molecules required for the recruitment of inflammatory cells [72, 73]. According to a review, whey protein can increase neutrophil infiltration by inhibiting oxidative markers and reactive oxygen species. In whey protein treated mice, the number of bone marrow-derived dendritic cells, T-cells, and B-cells increased in response to CCL-21 and CXCL-12 [74]. Cytokines released by neutrophils increase the proliferative and remodeling processes of cells; via this, the earliest signals responsible for the activation of fibroblasts and keratinocytes are produced [75, 76]. Neutrophils are involved in the early stages of the anti-inflammatory cascade by removing bacteria and phagocytosing cellular waste [77]. Various experiments have shown that priming blood neutrophils with proteins can trigger oxidative explosion, chemotaxis, degranulation, and phagocytosis [78]. Whey protein promotes the development of inflammatory proteins such as IL-1β, IL-8, IL-6 and TNF-α in macrophages [78, 79]. The initiation of NF-kB, which contributes to the development of inflammatory cascades and the release of pro-inflammatory cytokines for instance IL-1β, TNF-α, and IL-6 is one of whey protein’s anti-inflammatory processes [80, 81]. Inflammatory cytokines such as IL-1, IL-1, IL-10, and TNF-α were shown to be lower in the blood of mice feeding whey protein concentrate. Contrary to this, the amounts of cytokines such as IL-2, IL-4, IL-7, and IL-8, which are accountable for maintaining a healthy immune system, increased. The proliferative capacity of lymphocytes, monocytes, and macrophages in reaction to antigens was intensified [82].
6. Whey proteins role as anti-cancerous agents through production of inflammatory cytokines
Cancer is associated with a high rate of morbidity and mortality. According to a worldwide study, 27 main cancers were responsible for millions of deaths per year [81]. Dietetic modification has been proposed as an encouraging prophylactic strategy. Metabolites that modulate biomarkers of cancer began to emerge. Whey protein seems to be effective in this respect, and the assumptions have been supported by some data. In vitro, isolates of whey proteins had an impact on melanoma B16F10 cells that is cytotoxic in nature, as shown by the release of high caspase-3 [83]. According to a study performed on the rats suffering from gut cancer, fed whey protein hydrolysate, there were less tumor foci [84]. Before and after chemotherapy, a cervical cancer patient received whey protein (10 g three times quotidian) and a monthly testosterone infusion, which increased body lean mass, physical movement, and life quality [85]. Lactoferrin has been shown in vivo to stimulate cytokines in the guts and suppressing cancer growth in colon. Research established that consuming 3.0 g of bovine lactoferrin on a regular basis enhance the IFN levels that reduces the propagation of colorectal polyps [86]. While the available evidence is limited and the conclusion is far from definitive, but it might play a role of foundation for further research regarding anticancer experiments [21].
7. Whey protein as immunomodulators through maintenance of inflammatory cytokines
The complex network of lymphoid glands, effector cells, and molecules that make up the host immune defense is critical for survival [87]. Pathogenesis, metabolic, and degenerative disorders results as immunity lost. Dietary ingredients including probiotics, oligosaccharides, and β-glucans have been shown to have immune-boosting properties [88]. Whey proteins have been found to boost tolerance during childhood and thereby eliminate certain immune problems [89]. Whey proteins, upon digestion, found to activate variation among cells of immune system and recruitment of secondary lymphoid glands, according to a rodent report [89]. A comparative study among child’s who fed whey incorporated formula were and the kids who consumed bovine milk, the chances of atopic dermatitis were 16 percent less in the former than later group [90]. Psoriasis patients’ skin healed by taking 20 grams of whey protein isolate a day [21]. Although the psoriasis region and intensity score ranged from 4.9 to 28.8, it improved from 0.8 to 8.4 after 3 months of therapy. Higher glutathione levels and reduced systemic inflammation were linked to a reduction in autoimmune disorder symptoms [91].
8. Whey protein role in metabolic syndrome related to amelioration in pro-inflammatory cytokines
Hormones, cytokines and various other compounds involved to prohibit insulin sensitivity are produced by adipose tissue, an endocrine organ [66]. It is established that in the obese people, there is an increased discharge of adipocytokines through adipose tissue and macrophages [92]. Pal & Ellis [93] found that supplementing whey protein (54 g) for 12 weeks had little effect on pro-inflammatory markers (IL-6, C-reactive protein-CRP, and TNF-α) in overweight and obese participants. In rats with D-galactosamine-induced hepatitis and liver fibrosis, however, whey protein intake significantly decreased plasma amounts of pro-inflammatory cytokines (IL-1β: 59 percent and IL-6: 29 percent) as paralleled to casein consumption [37]. Since consuming whey protein and its amino acids, a decrease in pro-inflammatory cytokines can be linked to a reduction in body weight gain [94]. In streptozotocin-induced diabetic rats, whey protein fed in 100 mg amount related to body weight in kg and results showed the decrease in number of oxidative stress markers, like; MDA, nitric oxide, and ROS concentrations, as well as pro-inflammatory cytokines (IL-1, TNF-α, IL-6, and IL-4) and raised glutathione amount [81]. A study in which rats were fed with a food of more carbohydrate content, no fat diet to cause fatty livers (nonalcoholic fatty liver model) plus orally directed whey protein (0.15 g/d/rat) for 28 days resulted in decreased MDA and elevated glutathione levels [95]. Hence it can be concluded that whey proteins plays a vital role to enhance endogenous antioxidant enzymes (glutathione peroxidase, catalase, and superoxide dismutase) and limits oxidative stress markers in obese, diabetic, or stroke patients, along with low expression of pro-inflammatory cytokines (IL-1, IL-6, and TNF-α) [94]. TBARs are commonly used to measure lipid peroxidation products in cell and MDA is used as an oxidative stress marker. Summary of all cytokines related to whey proteins is discussed in Figure 3.
Figure 3.
Cytokine profile related to whey proteins; by inhibiting IL-1α, IL-1β, IL-6, TNF- α, CRP and IL-10 whey protein show anti-inflammatory effect while release of IL-2, IL-4, IL-7, IL-8 and TNF- α showed its immunity related function [60, 96, 97].
9. Whey protein hydrolysate downregulate inflammation-related genes
Bioactive peptides with anti-inflammatory effects, as well as amino acids, are used in dairy protein hydrolysates [98]. After the consumption of milk or yogurt, postprandial mRNA levels of inflammatory markers were shown to be lower in an acute clinical trial [99]. These findings indicate that dairy nutrients, as shown in mice, may control the transcriptome [100]. Low-grade systemic inflammation has been related to endothelial dysfunction and the progression of atherosclerosis in obese and/or T2D people [101]. Reduced nitric oxide (NO) supply and hence endothelial nitric oxide synthase (eNOS) activity characterize endothelial dysfunction. The research showed that lower the availability of NO, enhances the invasion of macrophages linked to adhering molecules like vascular cellular adhesion molecule (VCAM)–1, along with the discharge of proinflammatory cytokines like interleukins (ILs) and tumor necrosis factor (TNF–α) [102]. Antioxidant enzymes including superoxide dismutases (SOD) may even deactivate reactive oxygen species (ROS) that are connected to endothelial dysfunction [103]. Endothelial cells play an important role in inflammation. Dairy products’ special protein and amino acid composition can influence cytokine gene expression and development. However, mechanistic experiments comparing various dairy protein compounds are rare [104]. Whey proteins and their chief amino acids, BCAAs, shown an increased anti-inflammatory capacity compared to other proteins.
Whey protein hydrolysate and BCAA have anti-inflammatory properties by lowering TNF and VCAM-1 expression and thereby attenuating TNF-α induced gene expression. Similarly, whey proteins were found to have an anti-inflammatory impact in Caco-2 intestinal cells by lowering IL-8 production [105]. Whey proteins’ protective effects may be regulated by BCAAs. In HUVECs, BCAAs reduced the inflammatory reaction caused by TNF. In obese mice, induction of BCAAs, particularly leucine, reduced the appearance of genes involved in inflammation in the adipose tissue and liver, as well as macrophage infiltration [106].
In a rodent model of endothelial dysfunction, glutamine reduced the levels of circulating inflammatory markers (IL-6, IL-1, MIP-1, GM-CSF, MIP-2, IFN, and E-selectin) [107]. SOD2 expression is influenced by whey proteins and amino acids in the absence of TNF stimulation. WPH have been shown in to reduce inflammatory responses by constraining the nuclear factor κB (NF-κB) pathway [108]. Furthermore, glutamine, leucine, and proline have the ability to block the NF-κB pathway [109]. NF-κB is a transcription factor that controls the transcription of several inflammatory genes when it is triggered by proinflammatory signals like TNF-α. TNF, VCAM-1, and SOD2 are among the genes controlled by NF-κB [110], and these were the genes most affected by whey protein combinations in this study. As a result, it is established that by a route of NF-κB pathway, clear reduction in TNF-linked appearance of genes for inflammation through hydro-lysates and BCAAs of whey proteins could be achieved. Whey protein isolate, caseins, and WPC are entire proteins that can require other pathways. Autophagy, for example, has an effect on the functionality of mitochondria and oxidative stress, and that could be stimulated by proteins [111, 112].
10. IFN-γ, IL-8 and TGF-β expressions are downregulated by whey proteins
The most notable result of cow milk (CM0 whey therapy was the full abolition of interferon gamma (IFN-γ), as shown by extensive research. IFN-γ has a direct anti-proliferative effect on cancer cell lines. Studies have shown that mice lacking IFN-γ or IFN-γ receptor [113] as well as IFN-γ gene knockout (KO) mice grow cancer more quickly [114]. The late colitis stage and early neoplasms are reflected in the mouse examination and sample selection at 12th week. Dextral Sulfate Sodium (DSS) induced colitis was linked to an elevated level of IFN-γ, which was linked to decrease in weight and more death ratio [115]. Thus, the decreased IFN-γ amount results in the prohibition of immune cell recruitment to the inflammatory region and more tissue harm can clarify CM-mediated inhibition of inflammation. As a result, the neoplasm formation in CM-treated mice may have been influenced by lower mucosal inflammation. In a related vein, it has been shown that CM therapy reduced IFN-γ levels in chronic hepatitis B patients [116].
IL-8 has been shown to play a multifunctional role in cancer development, including encouraging tumor cell proliferation, improving cancer cell survival, and controlling adhesion and invasion [117]. Findings showed that cow milk (CM) significantly reduced IL-8 expression in colon tissue, suggesting that these results may reflect CM’s anti-inflammatory mechanism. It was found in a report on immunomodulatory function of milk proteins that IL-8 was recruited by Caco2 gut cells lined with the both α-lactalbumin and β-lactoglobulin of a non-fat bovine milk (BM) whey [118]. This phenomenon occurred by the activation of Caco2 cells by IL-1β. However, it is still needs to be confirmed that either the abstinence of β-LG in CM whey has any link to drop the IL-8 scale or graph in the CM treated population in model. Many studies have shown that all milk ingredients have a synergistic role in lowering IL-8 gene expression [118].
In addition, milk whey treatment reduced transforming growth factor (TGF-β) expression. TGF-β, a cytokine has double role in cancer growth and alteration in the TGF-β pathway within epithelial cells, promotes the enlargement and evolution of colonic tumors [118]. TGF-β signaling in tumor-infiltrating T-lymphocytes, on the other hand, led to the growth of dysplastic epithelial cells in experimental colorectal cancers (CRCs), according to contradictory findings [119]. Varying results on the role of TGF-β in CRC models could be described by the phase of cancer studied or the signaling pathway targeted by the cytokine in specific immune cells.
11. Conclusions
An interesting and verified phenomenon of bovine milk whey proteins is that they are known to act as anti-inflammatory and immune-stimulatory agents in connection with inflammatory and metabolic disorders.
According to molecular hypothesis, whey proteins decrease inflammatory cytokines (IL-1α, IL-1β, IL-10, and TNF-α) by molecularly inhibiting ACE and NF-κB expression, promoting Fas signaling, and increasing caspase-3 expression, while elevating GLP-1, PYY, CCK, GIP, and leptin, as well as chelating and binding iron, manganese, and zinc.
In this chapter, we have described about whey proteins’ essential significance in the molecular mechanisms associated with inflammatory health conditions. Whey protein also possesses many other impacts on different health issues on molecular level.
Acknowledgments
Authors acknowledge the role Food and Nutrition Society Gilgit Baltistan Pakistan for giving free access to journals.
Conflict of interest
Authors declare no conflict of interest.
Notes/thanks/other declarations
Authors pay special thanks to everyone for contribution.
nuclear factor kappa-light-chain-enhancer of activated B cells
PYY
Peptide YY
SOD2
Superoxide dismutase 2
SREBP-1c
Sterol regulatory element-binding protein 1
T2D
type 2 diabetes
TBARS
Thiobarbituric acid reactive substances
TGF-β
Transforming growth factor beta
TNF-a
Tumor Necrosis Factor alpha
UV
ultraviolet
w/w
weight per weight
WPCN
whey protein/casein mixture
(VCAM)–1
Vascular cellular adhesion molecule
\n',keywords:"Whey Proteins, Inflammatory Cytokines, Molecular Signaling",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/77716.pdf",chapterXML:"https://mts.intechopen.com/source/xml/77716.xml",downloadPdfUrl:"/chapter/pdf-download/77716",previewPdfUrl:"/chapter/pdf-preview/77716",totalDownloads:129,totalViews:0,totalCrossrefCites:1,dateSubmitted:"March 18th 2021",dateReviewed:"July 3rd 2021",datePrePublished:"August 17th 2021",datePublished:null,dateFinished:"July 28th 2021",readingETA:"0",abstract:"Whey proteins in bovine milk are a mixture of globular proteins manufactured from whey which is a byproduct of cheese industry. Whey protein is categorized to contain plethora of healthy components due to wide range of pH, promising nutritional profile with cost effective and diverse functionality. Reportedly there are three categories of whey protein, whey protein concentrate (WPC) (29–89%); whey protein isolate (WPI) 90% and whey protein hydrolysate (WPH) on the basis of proteins present in them. Whey proteins is composed of β-lactoglobulin (45–57%), immunoglobulins (10–15%) α-lactalbumin (15–25%), glicomacropeptide (10–15%), lactoperoxidase (<1%) and lactoferrin nearly (1%). Whey protein plays an important role and is validated to confer anti-inflammatory and immunostimulatory roles related to all metabolic syndromes. According to molecular point of view whey proteins decrease inflammatory cytokines (IL-1α, IL-1β, IL-10 and TNF- α); inhibits ACE and NF-κB expression; promotes Fas signaling and caspase-3 expression; elevates GLP-1, PYY, CCK, G1P and leptin; chelate and binds Fe+3, Mn+3 and Zn+2. In this chapter we will discuss significant biological role of whey proteins related to inflammatory health issues.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/77716",risUrl:"/chapter/ris/77716",signatures:"Anwar Ali, Quratul Ain, Ayesha Saeed, Waseem Khalid, Munir Ahmed and Ahmed Bostani",book:{id:"10887",type:"book",title:"New Advances in the Dairy Industry",subtitle:null,fullTitle:"New Advances in the Dairy Industry",slug:null,publishedDate:null,bookSignature:"Prof. Muhammad Subhan Qureshi",coverURL:"https://cdn.intechopen.com/books/images_new/10887.jpg",licenceType:"CC BY 3.0",editedByType:null,isbn:"978-1-83962-747-7",printIsbn:"978-1-83962-746-0",pdfIsbn:"978-1-83962-750-7",isAvailableForWebshopOrdering:!0,editors:[{id:"321396",title:"Prof.",name:"Muhammad Subhan",middleName:null,surname:"Qureshi",slug:"muhammad-subhan-qureshi",fullName:"Muhammad Subhan Qureshi"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:null,sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Components and types of whey proteins",level:"1"},{id:"sec_3",title:"3. Physiological and biological roles of whey proteins",level:"1"},{id:"sec_4",title:"4. Inflammatory cytokines in inflammatory process",level:"1"},{id:"sec_5",title:"5. Whey proteins leads to activation and production of pro-inflammatory cytokines",level:"1"},{id:"sec_6",title:"6. Whey proteins role as anti-cancerous agents through production of inflammatory cytokines",level:"1"},{id:"sec_7",title:"7. Whey protein as immunomodulators through maintenance of inflammatory cytokines",level:"1"},{id:"sec_8",title:"8. Whey protein role in metabolic syndrome related to amelioration in pro-inflammatory cytokines",level:"1"},{id:"sec_9",title:"9. Whey protein hydrolysate downregulate inflammation-related genes",level:"1"},{id:"sec_10",title:"10. IFN-γ, IL-8 and TGF-β expressions are downregulated by whey proteins",level:"1"},{id:"sec_11",title:"11. Conclusions",level:"1"},{id:"sec_12",title:"Acknowledgments",level:"1"},{id:"sec_15",title:"Conflict of interest",level:"1"},{id:"sec_12",title:"Notes/thanks/other declarations",level:"1"},{id:"sec_13",title:"Abbreviations",level:"1"}],chapterReferences:[{id:"B1",body:'Madureira AR, Pereira CI, Gomes AM, Pintado ME, Malcata FXJFRI. Bovine whey proteins–Overview on their main biological properties. 2007;40(10):1197-211.'},{id:"B2",body:'de Castro RJS, Domingues MAF, Ohara A, Okuro PK, dos Santos JG, Brexó RP, et al. Whey protein as a key component in food systems: Physicochemical properties, production technologies and applications. 2017;14:17-29.'},{id:"B3",body:'Pelegrine D, Gasparetto CJL-FS, Technology. Whey proteins solubility as function of temperature and pH. 2005;38(1):77-80.'},{id:"B4",body:'Zarogoulidis P, Tsakiridis K, Karapantzou C, Lampaki S, Kioumis I, Pitsiou G, et al. 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A multi-label classifier for predicting the subcellular localization of gram-negative bacterial proteins with both single and multiple sites. 2011;6(6):e20592.'},{id:"B108",body:'Malinowski J, Klempt M, Clawin-Rädecker I, Lorenzen PC, Meisel HJFc. Identification of a NFκB inhibitory peptide from tryptic β-casein hydrolysate. 2014;165:129-33.'},{id:"B109",body:'van Meijl LE, Popeijus HE, Mensink RPJMn, research f. Amino acids stimulate Akt phosphorylation, and reduce IL-8 production and NF-κB activity in HepG2 liver cells. 2010;54(11):1568-73.'},{id:"B110",body:'Kumar A, Takada Y, Boriek AM, Aggarwal BBJJomm. Nuclear factor-κB: its role in health and disease. 2004;82(7):434-48.'},{id:"B111",body:'Lee J, Giordano S, Zhang JJBJ. Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling. 2012;441(2):523-40.'},{id:"B112",body:'Da Silva MS, Bigo C, Barbier O, Rudkowska IJNR. Whey protein hydrolysate and branched-chain amino acids downregulate inflammation-related genes in vascular endothelial cells. 2017;38:43-51.'},{id:"B113",body:'Wang L, Wang Y, Song Z, Chu J, Qu XJJoI, Research C. Deficiency of interferon-gamma or its receptor promotes colorectal cancer development. 2015;35(4):273-80.'},{id:"B114",body:'Osawa E, Nakajima A, Fujisawa T, Kawamura YI, Toyama-Sorimachi N, Nakagama H, et al. Predominant T helper type 2-inflammatory responses promote murine colon cancers. 2006;118(9):2232-6.'},{id:"B115",body:'Ito R, Shin-Ya M, Kishida T, Urano A, Takada R, Sakagami J, et al. Interferon-gamma is causatively involved in experimental inflammatory bowel disease in mice. 2006;146(2):330-8.'},{id:"B116",body:'Saltanat H, Li H, Xu Y, Wang J, Liu F, Geng XJXbyfzmyxzzCjoc, et al. The influences of camel milk on the immune response of chronic hepatitis B patients. 2009;25(5):431-3.'},{id:"B117",body:'Rubie C, Frick VO, Pfeil S, Wagner M, Kollmar O, Kopp B, et al. Correlation of IL-8 with induction, progression and metastatic potential of colorectal cancer. 2007;13(37):4996.'},{id:"B118",body:'Ustunol Z, Wong CJJods. Effect of nonfat dry milk and major whey components on interleukin-6 and interleukin-8 production in human intestinal epithelial-like Caco-2 cells. 2010;93(6):2311-4.'},{id:"B119",body:'Becker C, Fantini MC, Schramm C, Lehr HA, Wirtz S, Nikolaev A, et al. TGF-β suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling. 2004;21(4):491-501.'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Anwar Ali",address:"206908003@csu.edu.cn",affiliation:'
Department of Epidemiology and Health Statistics, Xingya School of Public Health, Central South University, China
Department of Tourism and Hospitality Management, Dongbei University of Finance and Economics, China
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Definition of Terms:
\n\n
Book - collection of Works distributed in a book format, whose selection, coordination, preparation, and arrangement has been performed and published by IntechOpen, and in which the Work is included in its entirety in an unmodified form along with one or more other contributions, each constituting separate and independent sections, but together assembled into a collective whole.
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Work - a book Chapter (as well as Conference Papers), including any and all content, graphics, images and/or other materials forming part of, or accompanying, the Chapter/Conference Paper.
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Attribution – appropriate credit for the used Work or book.
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Creative Commons licenses – enable licensors to retain copyright while allowing others to use their Works in an appropriate way.
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Rules of Attribution for Works Published by IntechOpen
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With the purpose of protecting Authors' copyright and the transparent reuse of OA (Open Access) content, IntechOpen has developed Rules of Attribution of Works licensed under Creative Commons licenses.
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All Chapters published in IntechOpen books prior to October 2011 are licensed under the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported license (CC BY-NC-SA 3.0);
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All Chapters published in IntechOpen books after October 2011 are licensed under the Creative Commons Attribution 3.0 Unported license (CC BY 3.0);
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In case you reuse or republish any of the Works licensed under CC licenses, you must abide by the guidelines outlined below:
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1. Rules for reusing of books in their entirety or significant parts of books
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All rights to Books and other compilations published on the IntechOpen platform and in print are reserved by IntechOpen. The Copyright to Books and other compilations is subject to a separate Copyright from any that exists in the included Works.
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A Book in its entirety or a significant part of a Book cannot be translated freely without specific written consent by the publisher. Further information can be obtained at permissions@intechopen.com.
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In instances where permission is obtained from the publisher for reusing or republishing the Book, or significant parts of the Book, all of the following conditions apply:
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Information about the first publisher must be provided – please note the fact that the material was originally published by IntechOpen as an OA (Open Access) publication must be acknowledged;
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All original Academic Editor(s) must be credited;
\\n\\t
Since you are reusing content that someone else created and allowed you to use freely, you must credit all Authors involved;
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The type of license that is available for the Works must be indicated, as well as a link to the license provided, so that others can investigate the terms of the license. You will be aware that the material can be used for free in consequence of the CC license attribution, so you must acknowledge that fact. It is not sufficient that the material is Creative Commons, because that says nothing about how the material can actually be used. There are different CC licenses and you have to identify the specific license that is being used;
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Any original Copyright Notices associated, with the Works which constitute the Book must be kept intact;
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Provision of the original title of the Book, as well as the original titles of any individual Works;
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Provision of the URL where the Book is hosted, with a notice to the effect that the Book is an OA (Open Access) publication;
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Provision of the URL to every individual Work which constitutes the Book with a notice that the Work is an OA (Open Access) publication. As the material has been accessed for free, it is incumbent upon you to provide the source so that others can also access it for free.
\\n
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Every single Work that is used has to be attributed in the way described. If you are unsure about proper attribution, please write to permissions@intechopen.com.
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2. Rules of attribution for works published by IntechOpen
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Individual Works originally published in IntechOpen books are licensed under Creative Commons licenses and can be freely used under terms of the respective CC license, if properly attributed. In order to properly attribute the Work you must respect all the conditions outlined below:
\\n\\n
\\n\\t
Credit all Authors – since you are reusing contents that someone created and allowed you to use freely, you have to acknowledge authorship;
\\n\\t
Indicate the type of license under which the Work is available and provide the URL to the license so others can find out the license terms. Preferably keep intact any original Copyright Notice associated with the Chapter (if any). You will be aware that the material can be used for free in consequence of the CC license attribution, so you must acknowledge that fact. It is not sufficient that the material is Creative Commons, because that says nothing about how the material can actually be used. There are different CC licenses and you have to identify the specific license that is being used;
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Provide the URL where the Work is hosted, preferably providing the original title of the Work, as well as the original title of the Book with a notification that the Work is an OA (Open Access) publication. As the material has been accessed for free, it is incumbent upon you to provide the source so that others can also access it for free;
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Provide information about the first publisher – please note the fact that the material was originally published by IntechOpen as an OA (Open Access) Work must be acknowledged.
\\n
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Every single Work that is used has to be attributed in the way as described. If you are unsure about proper attribution, please contact Us at permissions@intechopen.com.
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In the event that you use more than one of IntechOpen's Works published in one or more books (but not a significant part of the book that is under separate Copyright), each of these have to be properly attributed in the way described.
\\n\\n
IntechOpen does not have any claims on newly created copyrighted Works, but the Works originally published by IntechOpen must be properly attributed.
\\n\\n
All these rules apply to BOTH online and offline use.
\\n\\n
Parts of the Rules of Attribution are based on Work Attributing Creative Commons Materials published by the Australian Research Council Centre of Excellence for Creative Industries and Innovation, in partnership with Creative Commons Australia, which can be found at creativecommons.org.au licensed under Creative Commons Attribution 2.5 Australia license, and Best practices for attribution published by Creative Commons, which can be found at wiki.creativecommons.org under the Creative Commons Attribution 4.0 license.
\\n\\n
All the above rules are subject to change, IntechOpen reserves the right to take appropriate action if any of the conditions outlined above are not met.
Work - a book Chapter (as well as Conference Papers), including any and all content, graphics, images and/or other materials forming part of, or accompanying, the Chapter/Conference Paper.
\n\n
Attribution – appropriate credit for the used Work or book.
\n\n
Creative Commons licenses – enable licensors to retain copyright while allowing others to use their Works in an appropriate way.
\n\n
Rules of Attribution for Works Published by IntechOpen
\n\n
With the purpose of protecting Authors' copyright and the transparent reuse of OA (Open Access) content, IntechOpen has developed Rules of Attribution of Works licensed under Creative Commons licenses.
\n\n
\n\t
All Chapters published in IntechOpen books prior to October 2011 are licensed under the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported license (CC BY-NC-SA 3.0);
\n\t
All Chapters published in IntechOpen books after October 2011 are licensed under the Creative Commons Attribution 3.0 Unported license (CC BY 3.0);
\n
\n\n
In case you reuse or republish any of the Works licensed under CC licenses, you must abide by the guidelines outlined below:
\n\n
1. Rules for reusing of books in their entirety or significant parts of books
\n\n
All rights to Books and other compilations published on the IntechOpen platform and in print are reserved by IntechOpen. The Copyright to Books and other compilations is subject to a separate Copyright from any that exists in the included Works.
\n\n
A Book in its entirety or a significant part of a Book cannot be translated freely without specific written consent by the publisher. Further information can be obtained at permissions@intechopen.com.
\n\n
In instances where permission is obtained from the publisher for reusing or republishing the Book, or significant parts of the Book, all of the following conditions apply:
\n\n
\n\t
Information about the first publisher must be provided – please note the fact that the material was originally published by IntechOpen as an OA (Open Access) publication must be acknowledged;
\n\t
All original Academic Editor(s) must be credited;
\n\t
Since you are reusing content that someone else created and allowed you to use freely, you must credit all Authors involved;
\n\t
The type of license that is available for the Works must be indicated, as well as a link to the license provided, so that others can investigate the terms of the license. You will be aware that the material can be used for free in consequence of the CC license attribution, so you must acknowledge that fact. It is not sufficient that the material is Creative Commons, because that says nothing about how the material can actually be used. There are different CC licenses and you have to identify the specific license that is being used;
\n\t
Any original Copyright Notices associated, with the Works which constitute the Book must be kept intact;
\n\t
Provision of the original title of the Book, as well as the original titles of any individual Works;
\n\t
Provision of the URL where the Book is hosted, with a notice to the effect that the Book is an OA (Open Access) publication;
\n\t
Provision of the URL to every individual Work which constitutes the Book with a notice that the Work is an OA (Open Access) publication. As the material has been accessed for free, it is incumbent upon you to provide the source so that others can also access it for free.
\n
\n\n
Every single Work that is used has to be attributed in the way described. If you are unsure about proper attribution, please write to permissions@intechopen.com.
\n\n
2. Rules of attribution for works published by IntechOpen
\n\n
Individual Works originally published in IntechOpen books are licensed under Creative Commons licenses and can be freely used under terms of the respective CC license, if properly attributed. In order to properly attribute the Work you must respect all the conditions outlined below:
\n\n
\n\t
Credit all Authors – since you are reusing contents that someone created and allowed you to use freely, you have to acknowledge authorship;
\n\t
Indicate the type of license under which the Work is available and provide the URL to the license so others can find out the license terms. Preferably keep intact any original Copyright Notice associated with the Chapter (if any). You will be aware that the material can be used for free in consequence of the CC license attribution, so you must acknowledge that fact. It is not sufficient that the material is Creative Commons, because that says nothing about how the material can actually be used. There are different CC licenses and you have to identify the specific license that is being used;
\n\t
Provide the URL where the Work is hosted, preferably providing the original title of the Work, as well as the original title of the Book with a notification that the Work is an OA (Open Access) publication. As the material has been accessed for free, it is incumbent upon you to provide the source so that others can also access it for free;
\n\t
Provide information about the first publisher – please note the fact that the material was originally published by IntechOpen as an OA (Open Access) Work must be acknowledged.
\n
\n\n
Every single Work that is used has to be attributed in the way as described. If you are unsure about proper attribution, please contact Us at permissions@intechopen.com.
\n\n
In the event that you use more than one of IntechOpen's Works published in one or more books (but not a significant part of the book that is under separate Copyright), each of these have to be properly attributed in the way described.
\n\n
IntechOpen does not have any claims on newly created copyrighted Works, but the Works originally published by IntechOpen must be properly attributed.
\n\n
All these rules apply to BOTH online and offline use.
\n\n
Parts of the Rules of Attribution are based on Work Attributing Creative Commons Materials published by the Australian Research Council Centre of Excellence for Creative Industries and Innovation, in partnership with Creative Commons Australia, which can be found at creativecommons.org.au licensed under Creative Commons Attribution 2.5 Australia license, and Best practices for attribution published by Creative Commons, which can be found at wiki.creativecommons.org under the Creative Commons Attribution 4.0 license.
\n\n
All the above rules are subject to change, IntechOpen reserves the right to take appropriate action if any of the conditions outlined above are not met.
\n\n
Policy last updated: 2016-06-09
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On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. 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In this work, an attempt is made to develop generic meta-heuristic scale for both known and unknown attacks with a high detection rate and low false alarm rate by adopting efficient feature optimization techniques.",book:{id:"8368",slug:"computer-and-network-security",title:"Computer and Network Security",fullTitle:"Computer and Network Security"},signatures:"Veeramreddy Jyothsna and Koneti Munivara Prasad",authors:[{id:"269941",title:"Mrs.",name:"Jyothsna",middleName:null,surname:"Veeramreddy",slug:"jyothsna-veeramreddy",fullName:"Jyothsna Veeramreddy"},{id:"321710",title:"Dr.",name:"Koneti Munivara",middleName:null,surname:"Prasad",slug:"koneti-munivara-prasad",fullName:"Koneti Munivara Prasad"}]},{id:"69737",title:"The DICOM Image Compression and Patient Data Integration using Run Length and Huffman Encoder",slug:"the-dicom-image-compression-and-patient-data-integration-using-run-length-and-huffman-encoder",totalDownloads:872,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"Maintaining human healthcare is one of the biggest challenges that most of the increasing population in Asian countries are facing today. There is an unrelenting need in our medical community to develop applications that are low on cost, with high compression, as huge number of patient’s data and images need to be transmitted over the network to be reviewed by the physicians for diagnostic purpose. This implemented work represents discrete wavelet-based threshold approach. Using this approach by applying N-level decomposition on 2D wavelet types like Biorthogonal, Haar, Daubechies, Coiflets, Symlets, Reverse Biorthogonal, and Discrete Meyer, various levels of wavelet coefficients are obtained. The lossless hybrid encoding algorithm, which combines run-length encoder and Huffman encoder, has been used for compression and decompression purpose. This work is proposed to examine the efficiency of different wavelet types and to determine the best. 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For Protecting the data communication between two communicating devices—three standard protocols i.e., WEP (Wired Equivalent Privacy), TKIP (Temporal Key Integrity Protocol) and AES-CCMP (Advanced Encryption Standard—Counter mode with CBC-MAC protocol) are used. Out of these, AES-CCMP protocol is secure enough and mostly used in enterprises. In WLAN environment lightweight authentication is an asset, provided it also satisfies other security properties like protecting the authentication stream or token along with securing the transmitted message. CAPWAP (Control and Provisioning of Wireless Access Points), HOKEY (Hand Over Keying) and IEEE 802.11r are major protocols for executing the secure handoff. In WLANs, handoff should not only be performed within time limits as required by the real time applications but should also be used to transfer safely the keying material for further communication. In this chapter, a comparative study of the security mechanisms under the above-mentioned research domains is provided.",book:{id:"8368",slug:"computer-and-network-security",title:"Computer and Network Security",fullTitle:"Computer and Network Security"},signatures:"Rajeev Singh and Teek Parval Sharma",authors:[{id:"267784",title:"Dr.",name:"Rajeev",middleName:null,surname:"Singh",slug:"rajeev-singh",fullName:"Rajeev Singh"},{id:"268313",title:"Dr.",name:"Teek Parval",middleName:null,surname:"Sharma",slug:"teek-parval-sharma",fullName:"Teek Parval Sharma"}]},{id:"64915",title:"Secure Communication Using Cryptography and Covert Channel",slug:"secure-communication-using-cryptography-and-covert-channel",totalDownloads:792,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"The keys which are generated by cryptography algorithms have still been compromised by attackers. So, they extra efforts to enhance security, time consumption and communication overheads. Encryption can achieve confidentiality but cannot achieve integrity. Authentication is needed beside encryption technique to achieve integrity. The client can send data indirectly to the server through a covert channel. The covert channel needs pre-shared information between parties before using the channel. The main challenges of covert channel are security of pre-agreement information and detectability. In this chapter, merging between encryption, authentication, and covert channel leads to a new covert channel satisfying integrity and confidentiality of sending data. This channel is used for secure communication that enables parties to agree on keys that are used for future communication.",book:{id:"8368",slug:"computer-and-network-security",title:"Computer and Network Security",fullTitle:"Computer and Network Security"},signatures:"Tamer S.A. Fatayer",authors:[{id:"267294",title:"Dr.",name:"Tamer",middleName:null,surname:"Fatayer",slug:"tamer-fatayer",fullName:"Tamer Fatayer"}]},{id:"67181",title:"Efficient Depth Estimation Using Sparse Stereo-Vision with Other Perception Techniques",slug:"efficient-depth-estimation-using-sparse-stereo-vision-with-other-perception-techniques",totalDownloads:1778,totalCrossrefCites:3,totalDimensionsCites:5,abstract:"The stereo vision system is one of the popular computer vision techniques. The idea here is to use the parallax error to our advantage. A single scene is recorded from two different viewing angles, and depth is estimated from the measure of parallax error. This technique is more than a century old and has proven useful in many applications. This field has made a lot of researchers and mathematicians to devise novel algorithms for the accurate output of the stereo systems. This system is particularly useful in the field of robotics. It provides them with the 3D understanding of the scene by giving them estimated object depths. This chapter, along with a complete overview of the stereo system, talks about the efficient estimation of the depth of the object. It stresses on the fact that if coupled with other perception techniques, stereo depth estimation can be made a lot more efficient than the current techniques. The idea revolves around the fact that stereo depth estimation is not necessary for all the pixels of the image. This fact opens room for more complex and accurate depth estimation techniques for the fewer regions of interest in the image scene. Further details about this idea are discussed in the subtopics that follow.",book:{id:"7623",slug:"coding-theory",title:"Coding Theory",fullTitle:"Coding Theory"},signatures:"Satyarth Praveen",authors:[{id:"277334",title:"Mr.",name:"Satyarth",middleName:null,surname:"Praveen",slug:"satyarth-praveen",fullName:"Satyarth Praveen"}]}],onlineFirstChaptersFilter:{topicId:"537",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:139,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:122,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:21,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:10,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. 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\r\n\tScientists have long researched to understand the environment and man’s place in it. The search for this knowledge grows in importance as rapid increases in population and economic development intensify humans’ stresses on ecosystems. Fortunately, rapid increases in multiple scientific areas are advancing our understanding of environmental sciences. Breakthroughs in computing, molecular biology, ecology, and sustainability science are enhancing our ability to utilize environmental sciences to address real-world problems. \r\n\tThe four topics of this book series - Pollution; Environmental Resilience and Management; Ecosystems and Biodiversity; and Water Science - will address important areas of advancement in the environmental sciences. They will represent an excellent initial grouping of published works on these critical topics.
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Dr. Summers is a systems ecologist and began his career at the EPA in 1989 and has worked in various programs and capacities. This includes leading the National Coastal Assessment in collaboration with the Office of Water which culminated in the award-winning National Coastal Condition Report series (four volumes between 2001 and 2012), and which integrates water quality, sediment quality, habitat, and biological data to assess the ecosystem condition of the United States estuaries. He was acting National Program Director for Ecology for the EPA between 2004 and 2006. He has authored approximately 150 peer-reviewed journal articles, book chapters, and reports and has received many awards for technical accomplishments from the EPA and from outside of the agency. Dr. Summers holds a BA in Zoology and Psychology, an MA in Ecology, and Ph.D. in Systems Ecology/Biology.",institutionString:null,institution:{name:"Environmental Protection Agency",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"38",title:"Pollution",coverUrl:"https://cdn.intechopen.com/series_topics/covers/38.jpg",isOpenForSubmission:!0,annualVolume:11966,editor:{id:"110740",title:"Dr.",name:"Ismail M.M.",middleName:null,surname:"Rahman",slug:"ismail-m.m.-rahman",fullName:"Ismail M.M. Rahman",profilePictureURL:"https://mts.intechopen.com/storage/users/110740/images/2319_n.jpg",biography:"Ismail Md. Mofizur Rahman (Ismail M. M. Rahman) assumed his current responsibilities as an Associate Professor at the Institute of Environmental Radioactivity, Fukushima University, Japan, in Oct 2015. He also has an honorary appointment to serve as a Collaborative Professor at Kanazawa University, Japan, from Mar 2015 to the present. \nFormerly, Dr. Rahman was a faculty member of the University of Chittagong, Bangladesh, affiliated with the Department of Chemistry (Oct 2002 to Mar 2012) and the Department of Applied Chemistry and Chemical Engineering (Mar 2012 to Sep 2015). Dr. Rahman was also adjunctly attached with Kanazawa University, Japan (Visiting Research Professor, Dec 2014 to Mar 2015; JSPS Postdoctoral Research Fellow, Apr 2012 to Mar 2014), and Tokyo Institute of Technology, Japan (TokyoTech-UNESCO Research Fellow, Oct 2004–Sep 2005). \nHe received his Ph.D. degree in Environmental Analytical Chemistry from Kanazawa University, Japan (2011). He also achieved a Diploma in Environment from the Tokyo Institute of Technology, Japan (2005). Besides, he has an M.Sc. degree in Applied Chemistry and a B.Sc. degree in Chemistry, all from the University of Chittagong, Bangladesh. \nDr. Rahman’s research interest includes the study of the fate and behavior of environmental pollutants in the biosphere; design of low energy and low burden environmental improvement (remediation) technology; implementation of sustainable waste management practices for treatment, handling, reuse, and ultimate residual disposition of solid wastes; nature and type of interactions in organic liquid mixtures for process engineering design applications.",institutionString:null,institution:{name:"Fukushima University",institutionURL:null,country:{name:"Japan"}}},editorTwo:{id:"201020",title:"Dr.",name:"Zinnat Ara",middleName:null,surname:"Begum",slug:"zinnat-ara-begum",fullName:"Zinnat Ara Begum",profilePictureURL:"https://mts.intechopen.com/storage/users/201020/images/system/201020.jpeg",biography:"Zinnat A. 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The research focus of Dr. Zinnat includes the effect of the relative stability of metal-chelator complexes in the environmental remediation process designs and the development of eco-friendly soil washing techniques using biodegradable chelators.",institutionString:null,institution:{name:"Fukushima University",institutionURL:null,country:{name:"Japan"}}},editorThree:null},{id:"39",title:"Environmental Resilience and Management",coverUrl:"https://cdn.intechopen.com/series_topics/covers/39.jpg",isOpenForSubmission:!0,annualVolume:11967,editor:{id:"137040",title:"Prof.",name:"Jose",middleName:null,surname:"Navarro-Pedreño",slug:"jose-navarro-pedreno",fullName:"Jose Navarro-Pedreño",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRAXrQAO/Profile_Picture_2022-03-09T15:50:19.jpg",biography:"Full professor at University Miguel Hernández of Elche, Spain, previously working at the University of Alicante, Autonomous University of Madrid and Polytechnic University of Valencia. Graduate in Sciences (Chemist), graduate in Geography and History (Geography), master in Water Management, Treatment, master in Fertilizers and Environment and master in Environmental Management; Ph.D. in Environmental Sciences. His research is focused on soil-water and waste-environment relations, mainly on soil-water and soil-waste interactions under different management and waste reuse. His work is reflected in more than 230 communications presented in national and international conferences and congresses, 29 invited lectures from universities, associations and government agencies. 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He has developed his research activity in the fields of fauna and soil ecology, and in the treatment of organic waste, having been the founder and principal investigator of the Environmental Biotechnology Group of the University of Vigo.\r\nHis research activity in the field of Environmental Biotechnology has been focused on the development of novel organic waste treatment systems through composting. The result of this line of work are three invention patents and various scientific and technical publications in prestigious international journals.",institutionString:null,institution:{name:"University of Vigo",institutionURL:null,country:{name:"Spain"}}},editorTwo:{id:"60498",title:"Prof.",name:"Josefina",middleName:null,surname:"Garrido",slug:"josefina-garrido",fullName:"Josefina Garrido",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRj1VQAS/Profile_Picture_2022-03-31T10:06:51.jpg",biography:"Josefina Garrido González (Paradela de Abeleda, Ourense 1959), is a doctor in biology from the University of León and a Professor of Zoology at the Department of Ecology and Animal Biology at the University of Vigo. She has focused her research activity on the taxonomy, fauna and ecology of aquatic beetles, in addition to other lines of research such as the conservation of biodiversity in freshwater ecosystems; conservation of protected areas (Red Natura 2000) and assessment of the effectiveness of wetlands as priority areas for the conservation of aquatic invertebrates; studies of water quality in freshwater ecosystems through biological indicators and physicochemical parameters; surveillance and research of vector arthropods and invasive alien species.",institutionString:null,institution:{name:"University of Vigo",institutionURL:null,country:{name:"Spain"}}},editorThree:{id:"464288",title:"Dr.",name:"Francisco",middleName:null,surname:"Ramil",slug:"francisco-ramil",fullName:"Francisco Ramil",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003RI7lHQAT/Profile_Picture_2022-03-31T10:15:35.png",biography:"Fran Ramil Blanco (Porto de Espasante, A Coruña, 1960), is a doctor in biology from the University of Santiago de Compostela and a Professor of Zoology at the Department of Ecology and Animal Biology at the University of Vigo. His research activity is linked to the taxonomy, fauna and ecology of marine benthic invertebrates and especially the Cnidarian group. Since 2004, he has been part of the EcoAfrik project, aimed at the study, protection and conservation of biodiversity and benthic habitats in West Africa. He also participated in the study of vulnerable marine ecosystems associated with seamounts in the South Atlantic and is involved in training young African researchers in the field of marine research.",institutionString:null,institution:{name:"University of Vigo",institutionURL:null,country:{name:"Spain"}}}},{id:"41",title:"Water Science",coverUrl:"https://cdn.intechopen.com/series_topics/covers/41.jpg",isOpenForSubmission:!0,annualVolume:11969,editor:{id:"349630",title:"Dr.",name:"Yizi",middleName:null,surname:"Shang",slug:"yizi-shang",fullName:"Yizi Shang",profilePictureURL:"https://mts.intechopen.com/storage/users/349630/images/system/349630.jpg",biography:"Prof. Dr. Yizi Shang is a pioneering researcher in hydrology and water resources who has devoted his research career to promoting the conservation and protection of water resources for sustainable development. He is presently associate editor of Water International (official journal of the International Water Resources Association). He was also invited to serve as an associate editor for special issues of the Journal of the American Water Resources Association. He has served as an editorial member for international journals such as Hydrology, Journal of Ecology & Natural Resources, and Hydro Science & Marine Engineering, among others. He has chaired or acted as a technical committee member for twenty-five international forums (conferences). Dr. Shang graduated from Tsinghua University, China, in 2010 with a Ph.D. in Engineering. Prior to that, he worked as a research fellow at Harvard University from 2008 to 2009. Dr. Shang serves as a senior research engineer at the China Institute of Water Resources and Hydropower Research (IWHR) and was awarded as a distinguished researcher at National Taiwan University in 2017.",institutionString:"China Institute of Water Resources and Hydropower Research",institution:{name:"China Institute of Water Resources and Hydropower Research",institutionURL:null,country:{name:"China"}}},editorTwo:null,editorThree:null}]},overviewPageOFChapters:{paginationCount:19,paginationItems:[{id:"82804",title:"Psychiatric Problems in HIV Care",doi:"10.5772/intechopen.106077",signatures:"Seggane Musisi and Noeline Nakasujja",slug:"psychiatric-problems-in-hiv-care",totalDownloads:1,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Future Opportunities and Tools for Emerging Challenges for HIV/AIDS Control",coverURL:"https://cdn.intechopen.com/books/images_new/11575.jpg",subseries:{id:"6",title:"Viral Infectious Diseases"}}},{id:"82827",title:"Epidemiology and Control of Schistosomiasis",doi:"10.5772/intechopen.105170",signatures:"Célestin Kyambikwa Bisangamo",slug:"epidemiology-and-control-of-schistosomiasis",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"New Horizons for Schistosomiasis Research",coverURL:"https://cdn.intechopen.com/books/images_new/10829.jpg",subseries:{id:"5",title:"Parasitic Infectious Diseases"}}},{id:"82817",title:"Perspective Chapter: Microfluidic Technologies for On-Site Detection and Quantification of Infectious Diseases - The Experience with SARS-CoV-2/COVID-19",doi:"10.5772/intechopen.105950",signatures:"Andres Escobar and Chang-qing Xu",slug:"perspective-chapter-microfluidic-technologies-for-on-site-detection-and-quantification-of-infectious",totalDownloads:2,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"SARS-CoV-2 Variants - Two Years After",coverURL:"https://cdn.intechopen.com/books/images_new/11573.jpg",subseries:{id:"6",title:"Viral Infectious Diseases"}}},{id:"82667",title:"Perspective Chapter: Analysis of SARS-CoV-2 Indirect Spreading Routes and Possible Countermeasures",doi:"10.5772/intechopen.105914",signatures:"Cesare Saccani, Marco Pellegrini and Alessandro Guzzini",slug:"perspective-chapter-analysis-of-sars-cov-2-indirect-spreading-routes-and-possible-countermeasures",totalDownloads:8,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"SARS-CoV-2 Variants - Two Years After",coverURL:"https://cdn.intechopen.com/books/images_new/11573.jpg",subseries:{id:"6",title:"Viral Infectious Diseases"}}}]},overviewPagePublishedBooks:{paginationCount:13,paginationItems:[{type:"book",id:"6667",title:"Influenza",subtitle:"Therapeutics and Challenges",coverURL:"https://cdn.intechopen.com/books/images_new/6667.jpg",slug:"influenza-therapeutics-and-challenges",publishedDate:"September 19th 2018",editedByType:"Edited by",bookSignature:"Shailendra K. 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Saxena",hash:"d92a4085627bab25ddc7942fbf44cf05",volumeInSeries:2,fullTitle:"Current Perspectives in Human Papillomavirus",editors:[{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Bacterial Infectious Diseases",value:3,count:2},{group:"subseries",caption:"Parasitic Infectious Diseases",value:5,count:4},{group:"subseries",caption:"Viral Infectious Diseases",value:6,count:7}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:2},{group:"publicationYear",caption:"2021",value:2021,count:4},{group:"publicationYear",caption:"2020",value:2020,count:3},{group:"publicationYear",caption:"2019",value:2019,count:3},{group:"publicationYear",caption:"2018",value:2018,count:1}],authors:{paginationCount:250,paginationItems:[{id:"274452",title:"Dr.",name:"Yousif",middleName:"Mohamed",surname:"Abdallah",slug:"yousif-abdallah",fullName:"Yousif Abdallah",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/274452/images/8324_n.jpg",biography:"I certainly enjoyed my experience in Radiotherapy and Nuclear Medicine, particularly it has been in different institutions and hospitals with different Medical Cultures and allocated resources. Radiotherapy and Nuclear Medicine Technology has always been my aspiration and my life. As years passed I accumulated a tremendous amount of skills and knowledge in Radiotherapy and Nuclear Medicine, Conventional Radiology, Radiation Protection, Bioinformatics Technology, PACS, Image processing, clinically and lecturing that will enable me to provide a valuable service to the community as a Researcher and Consultant in this field. My method of translating this into day to day in clinical practice is non-exhaustible and my habit of exchanging knowledge and expertise with others in those fields is the code and secret of success.",institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"313277",title:"Dr.",name:"Bartłomiej",middleName:null,surname:"Płaczek",slug:"bartlomiej-placzek",fullName:"Bartłomiej Płaczek",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/313277/images/system/313277.jpg",biography:"Bartłomiej Płaczek, MSc (2002), Ph.D. (2005), Habilitation (2016), is a professor at the University of Silesia, Institute of Computer Science, Poland, and an expert from the National Centre for Research and Development. His research interests include sensor networks, smart sensors, intelligent systems, and image processing with applications in healthcare and medicine. He is the author or co-author of more than seventy papers in peer-reviewed journals and conferences as well as the co-author of several books. He serves as a reviewer for many scientific journals, international conferences, and research foundations. Since 2010, Dr. Placzek has been a reviewer of grants and projects (including EU projects) in the field of information technologies.",institutionString:"University of Silesia",institution:{name:"University of Silesia",country:{name:"Poland"}}},{id:"35000",title:"Prof.",name:"Ulrich H.P",middleName:"H.P.",surname:"Fischer",slug:"ulrich-h.p-fischer",fullName:"Ulrich H.P Fischer",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/35000/images/3052_n.jpg",biography:"Academic and Professional Background\nUlrich H. P. has Diploma and PhD degrees in Physics from the Free University Berlin, Germany. He has been working on research positions in the Heinrich-Hertz-Institute in Germany. Several international research projects has been performed with European partners from France, Netherlands, Norway and the UK. He is currently Professor of Communications Systems at the Harz University of Applied Sciences, Germany.\n\nPublications and Publishing\nHe has edited one book, a special interest book about ‘Optoelectronic Packaging’ (VDE, Berlin, Germany), and has published over 100 papers and is owner of several international patents for WDM over POF key elements.\n\nKey Research and Consulting Interests\nUlrich’s research activity has always been related to Spectroscopy and Optical Communications Technology. Specific current interests include the validation of complex instruments, and the application of VR technology to the development and testing of measurement systems. He has been reviewer for several publications of the Optical Society of America\\'s including Photonics Technology Letters and Applied Optics.\n\nPersonal Interests\nThese include motor cycling in a very relaxed manner and performing martial arts.",institutionString:null,institution:{name:"Charité",country:{name:"Germany"}}},{id:"341622",title:"Ph.D.",name:"Eduardo",middleName:null,surname:"Rojas Alvarez",slug:"eduardo-rojas-alvarez",fullName:"Eduardo Rojas Alvarez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/341622/images/15892_n.jpg",biography:null,institutionString:null,institution:{name:"University of Cuenca",country:{name:"Ecuador"}}},{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/215610/images/system/215610.jpeg",biography:"Muhammad Sarfraz is a professor in the Department of Information Science, Kuwait University. His research interests include computer graphics, computer vision, image processing, machine learning, pattern recognition, soft computing, data science, intelligent systems, information technology, and information systems. Prof. Sarfraz has been a keynote/invited speaker on various platforms around the globe. He has advised various students for their MSc and Ph.D. theses. He has published more than 400 publications as books, journal articles, and conference papers. He is a member of various professional societies and a chair and member of the International Advisory Committees and Organizing Committees of various international conferences. Prof. Sarfraz is also an editor-in-chief and editor of various international journals.",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"32650",title:"Prof.",name:"Lukas",middleName:"Willem",surname:"Snyman",slug:"lukas-snyman",fullName:"Lukas Snyman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/32650/images/4136_n.jpg",biography:"Lukas Willem Snyman received his basic education at primary and high schools in South Africa, Eastern Cape. He enrolled at today's Nelson Metropolitan University and graduated from this university with a BSc in Physics and Mathematics, B.Sc Honors in Physics, MSc in Semiconductor Physics, and a Ph.D. in Semiconductor Physics in 1987. After his studies, he chose an academic career and devoted his energy to the teaching of physics to first, second, and third-year students. After positions as a lecturer at the University of Port Elizabeth, he accepted a position as Associate Professor at the University of Pretoria, South Africa.\r\n\r\nIn 1992, he motivates the concept of 'television and computer-based education” as means to reach large student numbers with only the best of teaching expertise and publishes an article on the concept in the SA Journal of Higher Education of 1993 (and later in 2003). The University of Pretoria subsequently approved a series of test projects on the concept with outreach to Mamelodi and Eerste Rust in 1993. In 1994, the University established a 'Unit for Telematic Education ' as a support section for multiple faculties at the University of Pretoria. In subsequent years, the concept of 'telematic education” subsequently becomes well established in academic circles in South Africa, grew in popularity, and is adopted by many universities and colleges throughout South Africa as a medium of enhancing education and training, as a method to reaching out to far out communities, and as a means to enhance study from the home environment.\r\n\r\nProfessor Snyman in subsequent years pursued research in semiconductor physics, semiconductor devices, microelectronics, and optoelectronics.\r\n\r\nIn 2000 he joined the TUT as a full professor. Here served for a period as head of the Department of Electronic Engineering. Here he makes contributions to solar energy development, microwave and optoelectronic device development, silicon photonics, as well as contributions to new mobile telecommunication systems and network planning in SA.\r\n\r\nCurrently, he teaches electronics and telecommunications at the TUT to audiences ranging from first-year students to Ph.D. level.\r\n\r\nFor his research in the field of 'Silicon Photonics” since 1990, he has published (as author and co-author) about thirty internationally reviewed articles in scientific journals, contributed to more than forty international conferences, about 25 South African provisional patents (as inventor and co-inventor), 8 PCT international patent applications until now. Of these, two USA patents applications, two European Patents, two Korean patents, and ten SA patents have been granted. A further 4 USA patents, 5 European patents, 3 Korean patents, 3 Chinese patents, and 3 Japanese patents are currently under consideration.\r\n\r\nRecently he has also published an extensive scholarly chapter in an internet open access book on 'Integrating Microphotonic Systems and MOEMS into standard Silicon CMOS Integrated circuitry”.\r\n\r\nFurthermore, Professor Snyman recently steered a new initiative at the TUT by introducing a 'Laboratory for Innovative Electronic Systems ' at the Department of Electrical Engineering. The model of this laboratory or center is to primarily combine outputs as achieved by high-level research with lower-level system development and entrepreneurship in a technical university environment. Students are allocated to projects at different levels with PhDs and Master students allocated to the generation of new knowledge and new technologies, while students at the diploma and Baccalaureus level are allocated to electronic systems development with a direct and a near application for application in industry or the commercial and public sectors in South Africa.\r\n\r\nProfessor Snyman received the WIRSAM Award of 1983 and the WIRSAM Award in 1985 in South Africa for best research papers by a young scientist at two international conferences on electron microscopy in South Africa. He subsequently received the SA Microelectronics Award for the best dissertation emanating from studies executed at a South African university in the field of Physics and Microelectronics in South Africa in 1987. In October of 2011, Professor Snyman received the prestigious Institutional Award for 'Innovator of the Year” for 2010 at the Tshwane University of Technology, South Africa. This award was based on the number of patents recognized and granted by local and international institutions as well as for his contributions concerning innovation at the TUT.",institutionString:null,institution:{name:"University of South Africa",country:{name:"South Africa"}}},{id:"317279",title:"Mr.",name:"Ali",middleName:"Usama",surname:"Syed",slug:"ali-syed",fullName:"Ali Syed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/317279/images/16024_n.png",biography:"A creative, talented, and innovative young professional who is dedicated, well organized, and capable research fellow with two years of experience in graduate-level research, published in engineering journals and book, with related expertise in Bio-robotics, equally passionate about the aesthetics of the mechanical and electronic system, obtained expertise in the use of MS Office, MATLAB, SolidWorks, LabVIEW, Proteus, Fusion 360, having a grasp on python, C++ and assembly language, possess proven ability in acquiring research grants, previous appointments with social and educational societies with experience in administration, current affiliations with IEEE and Web of Science, a confident presenter at conferences and teacher in classrooms, able to explain complex information to audiences of all levels.",institutionString:null,institution:{name:"Air University",country:{name:"Pakistan"}}},{id:"75526",title:"Ph.D.",name:"Zihni Onur",middleName:null,surname:"Uygun",slug:"zihni-onur-uygun",fullName:"Zihni Onur Uygun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/75526/images/12_n.jpg",biography:"My undergraduate education and my Master of Science educations at Ege University and at Çanakkale Onsekiz Mart University have given me a firm foundation in Biochemistry, Analytical Chemistry, Biosensors, Bioelectronics, Physical Chemistry and Medicine. After obtaining my degree as a MSc in analytical chemistry, I started working as a research assistant in Ege University Medical Faculty in 2014. In parallel, I enrolled to the MSc program at the Department of Medical Biochemistry at Ege University to gain deeper knowledge on medical and biochemical sciences as well as clinical chemistry in 2014. In my PhD I deeply researched on biosensors and bioelectronics and finished in 2020. Now I have eleven SCI-Expanded Index published papers, 6 international book chapters, referee assignments for different SCIE journals, one international patent pending, several international awards, projects and bursaries. In parallel to my research assistant position at Ege University Medical Faculty, Department of Medical Biochemistry, in April 2016, I also founded a Start-Up Company (Denosens Biotechnology LTD) by the support of The Scientific and Technological Research Council of Turkey. Currently, I am also working as a CEO in Denosens Biotechnology. The main purposes of the company, which carries out R&D as a research center, are to develop new generation biosensors and sensors for both point-of-care diagnostics; such as glucose, lactate, cholesterol and cancer biomarker detections. My specific experimental and instrumental skills are Biochemistry, Biosensor, Analytical Chemistry, Electrochemistry, Mobile phone based point-of-care diagnostic device, POCTs and Patient interface designs, HPLC, Tandem Mass Spectrometry, Spectrophotometry, ELISA.",institutionString:null,institution:{name:"Ege University",country:{name:"Turkey"}}},{id:"267434",title:"Dr.",name:"Rohit",middleName:null,surname:"Raja",slug:"rohit-raja",fullName:"Rohit Raja",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/267434/images/system/267434.jpg",biography:"Dr. Rohit Raja received Ph.D. in Computer Science and Engineering from Dr. CVRAMAN University in 2016. His main research interest includes Face recognition and Identification, Digital Image Processing, Signal Processing, and Networking. Presently he is working as Associate Professor in IT Department, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur (CG), India. He has authored several Journal and Conference Papers. He has good Academics & Research experience in various areas of CSE and IT. He has filed and successfully published 27 Patents. He has received many time invitations to be a Guest at IEEE Conferences. He has published 100 research papers in various International/National Journals (including IEEE, Springer, etc.) and Proceedings of the reputed International/ National Conferences (including Springer and IEEE). He has been nominated to the board of editors/reviewers of many peer-reviewed and refereed Journals (including IEEE, Springer).",institutionString:"Guru Ghasidas Vishwavidyalaya",institution:{name:"Guru Ghasidas Vishwavidyalaya",country:{name:"India"}}},{id:"246502",title:"Dr.",name:"Jaya T.",middleName:"T",surname:"Varkey",slug:"jaya-t.-varkey",fullName:"Jaya T. Varkey",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246502/images/11160_n.jpg",biography:"Jaya T. Varkey, PhD, graduated with a degree in Chemistry from Cochin University of Science and Technology, Kerala, India. She obtained a PhD in Chemistry from the School of Chemical Sciences, Mahatma Gandhi University, Kerala, India, and completed a post-doctoral fellowship at the University of Minnesota, USA. She is a research guide at Mahatma Gandhi University and Associate Professor in Chemistry, St. Teresa’s College, Kochi, Kerala, India.\nDr. Varkey received a National Young Scientist award from the Indian Science Congress (1995), a UGC Research award (2016–2018), an Indian National Science Academy (INSA) Visiting Scientist award (2018–2019), and a Best Innovative Faculty award from the All India Association for Christian Higher Education (AIACHE) (2019). She Hashas received the Sr. Mary Cecil prize for best research paper three times. She was also awarded a start-up to develop a tea bag water filter. \nDr. Varkey has published two international books and twenty-seven international journal publications. She is an editorial board member for five international journals.",institutionString:"St. Teresa’s College",institution:null},{id:"250668",title:"Dr.",name:"Ali",middleName:null,surname:"Nabipour Chakoli",slug:"ali-nabipour-chakoli",fullName:"Ali Nabipour Chakoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/250668/images/system/250668.jpg",biography:"Academic Qualification:\r\n•\tPhD in Materials Physics and Chemistry, From: Sep. 2006, to: Sep. 2010, School of Materials Science and Engineering, Harbin Institute of Technology, Thesis: Structure and Shape Memory Effect of Functionalized MWCNTs/poly (L-lactide-co-ε-caprolactone) Nanocomposites. Supervisor: Prof. Wei Cai,\r\n•\tM.Sc in Applied Physics, From: 1996, to: 1998, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Determination of Boron in Micro alloy Steels with solid state nuclear track detectors by neutron induced auto radiography, Supervisors: Dr. M. Hosseini Ashrafi and Dr. A. Hosseini.\r\n•\tB.Sc. in Applied Physics, From: 1991, to: 1996, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Design of shielding for Am-Be neutron sources for In Vivo neutron activation analysis, Supervisor: Dr. M. Hosseini Ashrafi.\r\n\r\nResearch Experiences:\r\n1.\tNanomaterials, Carbon Nanotubes, Graphene: Synthesis, Functionalization and Characterization,\r\n2.\tMWCNTs/Polymer Composites: Fabrication and Characterization, \r\n3.\tShape Memory Polymers, Biodegradable Polymers, ORC, Collagen,\r\n4.\tMaterials Analysis and Characterizations: TEM, SEM, XPS, FT-IR, Raman, DSC, DMA, TGA, XRD, GPC, Fluoroscopy, \r\n5.\tInteraction of Radiation with Mater, Nuclear Safety and Security, NDT(RT),\r\n6.\tRadiation Detectors, Calibration (SSDL),\r\n7.\tCompleted IAEA e-learning Courses:\r\nNuclear Security (15 Modules),\r\nNuclear Safety:\r\nTSA 2: Regulatory Protection in Occupational Exposure,\r\nTips & Tricks: Radiation Protection in Radiography,\r\nSafety and Quality in Radiotherapy,\r\nCourse on Sealed Radioactive Sources,\r\nCourse on Fundamentals of Environmental Remediation,\r\nCourse on Planning for Environmental Remediation,\r\nKnowledge Management Orientation Course,\r\nFood Irradiation - Technology, Applications and Good Practices,\r\nEmployment:\r\nFrom 2010 to now: Academic staff, Nuclear Science and Technology Research Institute, Kargar Shomali, Tehran, Iran, P.O. Box: 14395-836.\r\nFrom 1997 to 2006: Expert of Materials Analysis and Characterization. Research Center of Agriculture and Medicine. Rajaeeshahr, Karaj, Iran, P. O. Box: 31585-498.",institutionString:"Atomic Energy Organization of Iran",institution:{name:"Atomic Energy Organization of Iran",country:{name:"Iran"}}},{id:"248279",title:"Dr.",name:"Monika",middleName:"Elzbieta",surname:"Machoy",slug:"monika-machoy",fullName:"Monika Machoy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248279/images/system/248279.jpeg",biography:"Monika Elżbieta Machoy, MD, graduated with distinction from the Faculty of Medicine and Dentistry at the Pomeranian Medical University in 2009, defended her PhD thesis with summa cum laude in 2016 and is currently employed as a researcher at the Department of Orthodontics of the Pomeranian Medical University. She expanded her professional knowledge during a one-year scholarship program at the Ernst Moritz Arndt University in Greifswald, Germany and during a three-year internship at the Technical University in Dresden, Germany. She has been a speaker at numerous orthodontic conferences, among others, American Association of Orthodontics, European Orthodontic Symposium and numerous conferences of the Polish Orthodontic Society. She conducts research focusing on the effect of orthodontic treatment on dental and periodontal tissues and the causes of pain in orthodontic patients.",institutionString:"Pomeranian Medical University",institution:{name:"Pomeranian Medical University",country:{name:"Poland"}}},{id:"252743",title:"Prof.",name:"Aswini",middleName:"Kumar",surname:"Kar",slug:"aswini-kar",fullName:"Aswini Kar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252743/images/10381_n.jpg",biography:"uploaded in cv",institutionString:null,institution:{name:"KIIT University",country:{name:"India"}}},{id:"204256",title:"Dr.",name:"Anil",middleName:"Kumar",surname:"Kumar Sahu",slug:"anil-kumar-sahu",fullName:"Anil Kumar Sahu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204256/images/14201_n.jpg",biography:"I have nearly 11 years of research and teaching experience. I have done my master degree from University Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur, Chhattisgarh India. I have published 16 review and research articles in international and national journals and published 4 chapters in IntechOpen, the world’s leading publisher of Open access books. I have presented many papers at national and international conferences. I have received research award from Indian Drug Manufacturers Association in year 2015. My research interest extends from novel lymphatic drug delivery systems, oral delivery system for herbal bioactive to formulation optimization.",institutionString:null,institution:{name:"Chhattisgarh Swami Vivekanand Technical University",country:{name:"India"}}},{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",biography:"An assistant professor at Department of Biomedical Computer Systems, at Institute of Computer Science, Silesian University in Katowice. Scientific interests: computer analysis and processing of images, biomedical images, databases and programming languages. He is an author and co-author of scientific publications covering analysis and processing of biomedical images and development of database systems.",institutionString:"University of Silesia",institution:{name:"University of Silesia",country:{name:"Poland"}}},{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",biography:"Dr. Hadi Mohammadi is a biomedical engineer with hands-on experience in the design and development of many engineering structures and medical devices through various projects that he has been involved in over the past twenty years. Dr. Mohammadi received his BSc. and MSc. degrees in Mechanical Engineering from Sharif University of Technology, Tehran, Iran, and his PhD. degree in Biomedical Engineering (biomaterials) from the University of Western Ontario. He was a postdoctoral trainee for almost four years at University of Calgary and Harvard Medical School. He is an industry innovator having created the technology to produce lifelike synthetic platforms that can be used for the simulation of almost all cardiovascular reconstructive surgeries. He’s been heavily involved in the design and development of cardiovascular devices and technology for the past 10 years. He is currently an Assistant Professor with the University of British Colombia, Canada.",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",country:{name:"Canada"}}},{id:"254463",title:"Prof.",name:"Haisheng",middleName:null,surname:"Yang",slug:"haisheng-yang",fullName:"Haisheng Yang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/254463/images/system/254463.jpeg",biography:"Haisheng Yang, Ph.D., Professor and Director of the Department of Biomedical Engineering, College of Life Science and Bioengineering, Beijing University of Technology. He received his Ph.D. degree in Mechanics/Biomechanics from Harbin Institute of Technology (jointly with University of California, Berkeley). Afterwards, he worked as a Postdoctoral Research Associate in the Purdue Musculoskeletal Biology and Mechanics Lab at the Department of Basic Medical Sciences, Purdue University, USA. He also conducted research in the Research Centre of Shriners Hospitals for Children-Canada at McGill University, Canada. Dr. Yang has over 10 years research experience in orthopaedic biomechanics and mechanobiology of bone adaptation and regeneration. He earned an award from Beijing Overseas Talents Aggregation program in 2017 and serves as Beijing Distinguished Professor.",institutionString:null,institution:{name:"Beijing University of Technology",country:{name:"China"}}},{id:"89721",title:"Dr.",name:"Mehmet",middleName:"Cuneyt",surname:"Ozmen",slug:"mehmet-ozmen",fullName:"Mehmet Ozmen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/89721/images/7289_n.jpg",biography:null,institutionString:null,institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"265335",title:"Mr.",name:"Stefan",middleName:"Radnev",surname:"Stefanov",slug:"stefan-stefanov",fullName:"Stefan Stefanov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/265335/images/7562_n.jpg",biography:null,institutionString:null,institution:{name:"Medical University Plovdiv",country:{name:"Bulgaria"}}},{id:"242893",title:"Ph.D. Student",name:"Joaquim",middleName:null,surname:"De Moura",slug:"joaquim-de-moura",fullName:"Joaquim De Moura",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/242893/images/7133_n.jpg",biography:"Joaquim de Moura received his degree in Computer Engineering in 2014 from the University of A Coruña (Spain). In 2016, he received his M.Sc degree in Computer Engineering from the same university. He is currently pursuing his Ph.D degree in Computer Science in a collaborative project between ophthalmology centers in Galicia and the University of A Coruña. His research interests include computer vision, machine learning algorithms and analysis and medical imaging processing of various kinds.",institutionString:null,institution:{name:"University of A Coruña",country:{name:"Spain"}}},{id:"294334",title:"B.Sc.",name:"Marc",middleName:null,surname:"Bruggeman",slug:"marc-bruggeman",fullName:"Marc Bruggeman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/294334/images/8242_n.jpg",biography:"Chemical engineer graduate, with a passion for material science and specific interest in polymers - their near infinite applications intrigue me. \n\nI plan to continue my scientific career in the field of polymeric biomaterials as I am fascinated by intelligent, bioactive and biomimetic materials for use in both consumer and medical applications.",institutionString:null,institution:null},{id:"255757",title:"Dr.",name:"Igor",middleName:"Victorovich",surname:"Lakhno",slug:"igor-lakhno",fullName:"Igor Lakhno",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255757/images/system/255757.jpg",biography:"Igor Victorovich Lakhno was born in 1971 in Kharkiv (Ukraine). \nMD – 1994, Kharkiv National Medical Univesity.\nOb&Gyn; – 1997, master courses in Kharkiv Medical Academy of Postgraduate Education.\nPh.D. – 1999, Kharkiv National Medical Univesity.\nDSC – 2019, PL Shupik National Academy of Postgraduate Education \nProfessor – 2021, Department of Obstetrics and Gynecology of VN Karazin Kharkiv National University\nHead of Department – 2021, Department of Perinatology, Obstetrics and gynecology of Kharkiv Medical Academy of Postgraduate Education\nIgor Lakhno has been graduated from international training courses on reproductive medicine and family planning held at Debrecen University (Hungary) in 1997. Since 1998 Lakhno Igor has worked as an associate professor in the department of obstetrics and gynecology of VN Karazin National University and an associate professor of the perinatology, obstetrics, and gynecology department of Kharkiv Medical Academy of Postgraduate Education. Since June 2019 he’s been a professor in the department of obstetrics and gynecology of VN Karazin National University and a professor of the perinatology, obstetrics, and gynecology department. He’s affiliated with Kharkiv Medical Academy of Postgraduate Education as a Head of Department from November 2021. Igor Lakhno has participated in several international projects on fetal non-invasive electrocardiography (with Dr. J. A. Behar (Technion), Prof. D. Hoyer (Jena University), and José Alejandro Díaz Méndez (National Institute of Astrophysics, Optics, and Electronics, Mexico). He’s an author of about 200 printed works and there are 31 of them in Scopus or Web of Science databases. Igor Lakhno is a member of the Editorial Board of Reproductive Health of Woman, Emergency Medicine, and Technology Transfer Innovative Solutions in Medicine (Estonia). He is a medical Editor of “Z turbotoyu pro zhinku”. Igor Lakhno is a reviewer of the Journal of Obstetrics and Gynaecology (Taylor and Francis), British Journal of Obstetrics and Gynecology (Wiley), Informatics in Medicine Unlocked (Elsevier), The Journal of Obstetrics and Gynecology Research (Wiley), Endocrine, Metabolic & Immune Disorders-Drug Targets (Bentham Open), The Open Biomedical Engineering Journal (Bentham Open), etc. He’s defended a dissertation for a DSc degree “Pre-eclampsia: prediction, prevention, and treatment”. Three years ago Igor Lakhno has participated in a training course on innovative technologies in medical education at Lublin Medical University (Poland). Lakhno Igor has participated as a speaker in several international conferences and congresses (International Conference on Biological Oscillations April 10th-14th 2016, Lancaster, UK, The 9th conference of the European Study Group on Cardiovascular Oscillations). His main scientific interests: are obstetrics, women’s health, fetal medicine, and cardiovascular medicine. \nIgor Lakhno is a consultant at Kharkiv municipal perinatal center. He’s graduated from training courses on endoscopy in gynecology. He has 28 years of practical experience in the field.",institutionString:null,institution:null},{id:"244950",title:"Dr.",name:"Salvatore",middleName:null,surname:"Di Lauro",slug:"salvatore-di-lauro",fullName:"Salvatore Di Lauro",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0030O00002bSF1HQAW/ProfilePicture%202021-12-20%2014%3A54%3A14.482",biography:"Name:\n\tSALVATORE DI LAURO\nAddress:\n\tHospital Clínico Universitario Valladolid\nAvda Ramón y Cajal 3\n47005, Valladolid\nSpain\nPhone number: \nFax\nE-mail:\n\t+34 983420000 ext 292\n+34 983420084\nsadilauro@live.it\nDate and place of Birth:\nID Number\nMedical Licence \nLanguages\t09-05-1985. Villaricca (Italy)\n\nY1281863H\n474707061\nItalian (native language)\nSpanish (read, written, spoken)\nEnglish (read, written, spoken)\nPortuguese (read, spoken)\nFrench (read)\n\t\t\nCurrent position (title and company)\tDate (Year)\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. Private practise.\t2017-today\n\n2019-today\n\t\n\t\nEducation (High school, university and postgraduate training > 3 months)\tDate (Year)\nDegree in Medicine and Surgery. University of Neaples 'Federico II”\nResident in Opthalmology. Hospital Clinico Universitario Valladolid\nMaster in Vitreo-Retina. IOBA. University of Valladolid\nFellow of the European Board of Ophthalmology. Paris\nMaster in Research in Ophthalmology. University of Valladolid\t2003-2009\n2012-2016\n2016-2017\n2016\n2012-2013\n\t\nEmployments (company and positions)\tDate (Year)\nResident in Ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl.\nFellow in Vitreo-Retina. IOBA. University of Valladolid\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. \n\t2012-2016\n2016-2017\n2017-today\n\n2019-Today\n\n\n\t\nClinical Research Experience (tasks and role)\tDate (Year)\nAssociated investigator\n\n' FIS PI20/00740: DESARROLLO DE UNA CALCULADORA DE RIESGO DE\nAPARICION DE RETINOPATIA DIABETICA BASADA EN TECNICAS DE IMAGEN MULTIMODAL EN PACIENTES DIABETICOS TIPO 1. Grant by: Ministerio de Ciencia e Innovacion \n\n' (BIO/VA23/14) Estudio clínico multicéntrico y prospectivo para validar dos\nbiomarcadores ubicados en los genes p53 y MDM2 en la predicción de los resultados funcionales de la cirugía del desprendimiento de retina regmatógeno. Grant by: Gerencia Regional de Salud de la Junta de Castilla y León.\n' Estudio multicéntrico, aleatorizado, con enmascaramiento doble, en 2 grupos\nparalelos y de 52 semanas de duración para comparar la eficacia, seguridad e inmunogenicidad de SOK583A1 respecto a Eylea® en pacientes con degeneración macular neovascular asociada a la edad' (CSOK583A12301; N.EUDRA: 2019-004838-41; FASE III). Grant by Hexal AG\n\n' Estudio de fase III, aleatorizado, doble ciego, con grupos paralelos, multicéntrico para comparar la eficacia y la seguridad de QL1205 frente a Lucentis® en pacientes con degeneración macular neovascular asociada a la edad. (EUDRACT: 2018-004486-13). Grant by Qilu Pharmaceutical Co\n\n' Estudio NEUTON: Ensayo clinico en fase IV para evaluar la eficacia de aflibercept en pacientes Naive con Edema MacUlar secundario a Oclusion de Vena CenTral de la Retina (OVCR) en regimen de tratamientO iNdividualizado Treat and Extend (TAE)”, (2014-000975-21). Grant by Fundacion Retinaplus\n\n' Evaluación de la seguridad y bioactividad de anillos de tensión capsular en conejo. Proyecto Procusens. Grant by AJL, S.A.\n\n'Estudio epidemiológico, prospectivo, multicéntrico y abierto\\npara valorar la frecuencia de la conjuntivitis adenovírica diagnosticada mediante el test AdenoPlus®\\nTest en pacientes enfermos de conjuntivitis aguda”\\n. National, multicenter study. Grant by: NICOX.\n\nEuropean multicentric trial: 'Evaluation of clinical outcomes following the use of Systane Hydration in patients with dry eye”. Study Phase 4. Grant by: Alcon Labs'\n\nVLPs Injection and Activation in a Rabbit Model of Uveal Melanoma. Grant by Aura Bioscience\n\nUpdating and characterization of a rabbit model of uveal melanoma. Grant by Aura Bioscience\n\nEnsayo clínico en fase IV para evaluar las variantes genéticas de la vía del VEGF como biomarcadores de eficacia del tratamiento con aflibercept en pacientes con degeneración macular asociada a la edad (DMAE) neovascular. Estudio BIOIMAGE. IMO-AFLI-2013-01\n\nEstudio In-Eye:Ensayo clínico en fase IV, abierto, aleatorizado, de 2 brazos,\nmulticçentrico y de 12 meses de duración, para evaluar la eficacia y seguridad de un régimen de PRN flexible individualizado de 'esperar y extender' versus un régimen PRN según criterios de estabilización mediante evaluaciones mensuales de inyecciones intravítreas de ranibizumab 0,5 mg en pacientes naive con neovascularización coriodea secunaria a la degeneración macular relacionada con la edad. CP: CRFB002AES03T\n\nTREND: Estudio Fase IIIb multicéntrico, randomizado, de 12 meses de\nseguimiento con evaluador de la agudeza visual enmascarado, para evaluar la eficacia y la seguridad de ranibizumab 0.5mg en un régimen de tratar y extender comparado con un régimen mensual, en pacientes con degeneración macular neovascular asociada a la edad. CP: CRFB002A2411 Código Eudra CT:\n2013-002626-23\n\n\n\nPublications\t\n\n2021\n\n\n\n\n2015\n\n\n\n\n2021\n\n\n\n\n\n2021\n\n\n\n\n2015\n\n\n\n\n2015\n\n\n2014\n\n\n\n\n2015-16\n\n\n\n2015\n\n\n2014\n\n\n2014\n\n\n\n\n2014\n\n\n\n\n\n\n\n2014\n\nJose Carlos Pastor; Jimena Rojas; Salvador Pastor-Idoate; Salvatore Di Lauro; Lucia Gonzalez-Buendia; Santiago Delgado-Tirado. Proliferative vitreoretinopathy: A new concept of disease pathogenesis and practical\nconsequences. Progress in Retinal and Eye Research. 51, pp. 125 - 155. 03/2016. DOI: 10.1016/j.preteyeres.2015.07.005\n\n\nLabrador-Velandia S; Alonso-Alonso ML; Di Lauro S; García-Gutierrez MT; Srivastava GK; Pastor JC; Fernandez-Bueno I. Mesenchymal stem cells provide paracrine neuroprotective resources that delay degeneration of co-cultured organotypic neuroretinal cultures.Experimental Eye Research. 185, 17/05/2019. DOI: 10.1016/j.exer.2019.05.011\n\nSalvatore Di Lauro; Maria Teresa Garcia Gutierrez; Ivan Fernandez Bueno. Quantification of pigment epithelium-derived factor (PEDF) in an ex vivo coculture of retinal pigment epithelium cells and neuroretina.\nJournal of Allbiosolution. 2019. ISSN 2605-3535\n\nSonia Labrador Velandia; Salvatore Di Lauro; Alonso-Alonso ML; Tabera Bartolomé S; Srivastava GK; Pastor JC; Fernandez-Bueno I. Biocompatibility of intravitreal injection of human mesenchymal stem cells in immunocompetent rabbits. Graefe's archive for clinical and experimental ophthalmology. 256 - 1, pp. 125 - 134. 01/2018. DOI: 10.1007/s00417-017-3842-3\n\n\nSalvatore Di Lauro, David Rodriguez-Crespo, Manuel J Gayoso, Maria T Garcia-Gutierrez, J Carlos Pastor, Girish K Srivastava, Ivan Fernandez-Bueno. A novel coculture model of porcine central neuroretina explants and retinal pigment epithelium cells. Molecular Vision. 2016 - 22, pp. 243 - 253. 01/2016.\n\nSalvatore Di Lauro. Classifications for Proliferative Vitreoretinopathy ({PVR}): An Analysis of Their Use in Publications over the Last 15 Years. Journal of Ophthalmology. 2016, pp. 1 - 6. 01/2016. DOI: 10.1155/2016/7807596\n\nSalvatore Di Lauro; Rosa Maria Coco; Rosa Maria Sanabria; Enrique Rodriguez de la Rua; Jose Carlos Pastor. Loss of Visual Acuity after Successful Surgery for Macula-On Rhegmatogenous Retinal Detachment in a Prospective Multicentre Study. Journal of Ophthalmology. 2015:821864, 2015. DOI: 10.1155/2015/821864\n\nIvan Fernandez-Bueno; Salvatore Di Lauro; Ivan Alvarez; Jose Carlos Lopez; Maria Teresa Garcia-Gutierrez; Itziar Fernandez; Eva Larra; Jose Carlos Pastor. Safety and Biocompatibility of a New High-Density Polyethylene-Based\nSpherical Integrated Porous Orbital Implant: An Experimental Study in Rabbits. Journal of Ophthalmology. 2015:904096, 2015. DOI: 10.1155/2015/904096\n\nPastor JC; Pastor-Idoate S; Rodríguez-Hernandez I; Rojas J; Fernandez I; Gonzalez-Buendia L; Di Lauro S; Gonzalez-Sarmiento R. Genetics of PVR and RD. Ophthalmologica. 232 - Suppl 1, pp. 28 - 29. 2014\n\nRodriguez-Crespo D; Di Lauro S; Singh AK; Garcia-Gutierrez MT; Garrosa M; Pastor JC; Fernandez-Bueno I; Srivastava GK. Triple-layered mixed co-culture model of RPE cells with neuroretina for evaluating the neuroprotective effects of adipose-MSCs. Cell Tissue Res. 358 - 3, pp. 705 - 716. 2014.\nDOI: 10.1007/s00441-014-1987-5\n\nCarlo De Werra; Salvatore Condurro; Salvatore Tramontano; Mario Perone; Ivana Donzelli; Salvatore Di Lauro; Massimo Di Giuseppe; Rosa Di Micco; Annalisa Pascariello; Antonio Pastore; Giorgio Diamantis; Giuseppe Galloro. Hydatid disease of the liver: thirty years of surgical experience.Chirurgia italiana. 59 - 5, pp. 611 - 636.\n(Italia): 2007. ISSN 0009-4773\n\nChapters in books\n\t\n' Salvador Pastor Idoate; Salvatore Di Lauro; Jose Carlos Pastor Jimeno. PVR: Pathogenesis, Histopathology and Classification. Proliferative Vitreoretinopathy with Small Gauge Vitrectomy. Springer, 2018. ISBN 978-3-319-78445-8\nDOI: 10.1007/978-3-319-78446-5_2. \n\n' Salvatore Di Lauro; Maria Isabel Lopez Galvez. Quistes vítreos en una mujer joven. Problemas diagnósticos en patología retinocoroidea. Sociedad Española de Retina-Vitreo. 2018.\n\n' Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor Jimeno. iOCT in PVR management. OCT Applications in Opthalmology. pp. 1 - 8. INTECH, 2018. DOI: 10.5772/intechopen.78774.\n\n' Rosa Coco Martin; Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor. amponadores, manipuladores y tinciones en la cirugía del traumatismo ocular.Trauma Ocular. Ponencia de la SEO 2018..\n\n' LOPEZ GALVEZ; DI LAURO; CRESPO. OCT angiografia y complicaciones retinianas de la diabetes. PONENCIA SEO 2021, CAPITULO 20. (España): 2021.\n\n' Múltiples desprendimientos neurosensoriales bilaterales en paciente joven. Enfermedades Degenerativas De Retina Y Coroides. SERV 04/2016. \n' González-Buendía L; Di Lauro S; Pastor-Idoate S; Pastor Jimeno JC. Vitreorretinopatía proliferante (VRP) e inflamación: LA INFLAMACIÓN in «INMUNOMODULADORES Y ANTIINFLAMATORIOS: MÁS ALLÁ DE LOS CORTICOIDES. RELACION DE PONENCIAS DE LA SOCIEDAD ESPAÑOLA DE OFTALMOLOGIA. 10/2014.",institutionString:null,institution:null},{id:"243698",title:"Dr.",name:"Xiaogang",middleName:null,surname:"Wang",slug:"xiaogang-wang",fullName:"Xiaogang Wang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243698/images/system/243698.png",biography:"Dr. Xiaogang Wang, a faculty member of Shanxi Eye Hospital specializing in the treatment of cataract and retinal disease and a tutor for postgraduate students of Shanxi Medical University, worked in the COOL Lab as an international visiting scholar under the supervision of Dr. David Huang and Yali Jia from October 2012 through November 2013. Dr. Wang earned an MD from Shanxi Medical University and a Ph.D. from Shanghai Jiao Tong University. Dr. Wang was awarded two research project grants focused on multimodal optical coherence tomography imaging and deep learning in cataract and retinal disease, from the National Natural Science Foundation of China. He has published around 30 peer-reviewed journal papers and four book chapters and co-edited one book.",institutionString:null,institution:null},{id:"7227",title:"Dr.",name:"Hiroaki",middleName:null,surname:"Matsui",slug:"hiroaki-matsui",fullName:"Hiroaki Matsui",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Tokyo",country:{name:"Japan"}}},{id:"312999",title:"Dr.",name:"Bernard O.",middleName:null,surname:"Asimeng",slug:"bernard-o.-asimeng",fullName:"Bernard O. Asimeng",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Ghana",country:{name:"Ghana"}}},{id:"318905",title:"Prof.",name:"Elvis",middleName:"Kwason",surname:"Tiburu",slug:"elvis-tiburu",fullName:"Elvis Tiburu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Ghana",country:{name:"Ghana"}}},{id:"336193",title:"Dr.",name:"Abdullah",middleName:null,surname:"Alamoudi",slug:"abdullah-alamoudi",fullName:"Abdullah Alamoudi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"318657",title:"MSc.",name:"Isabell",middleName:null,surname:"Steuding",slug:"isabell-steuding",fullName:"Isabell Steuding",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Harz University of Applied Sciences",country:{name:"Germany"}}},{id:"318656",title:"BSc.",name:"Peter",middleName:null,surname:"Kußmann",slug:"peter-kussmann",fullName:"Peter Kußmann",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Harz University of Applied Sciences",country:{name:"Germany"}}}]}},subseries:{item:{id:"10",type:"subseries",title:"Animal Physiology",keywords:"Physiology, Comparative, Evolution, Biomolecules, Organ, Homeostasis, Anatomy, Pathology, Medical, Cell Division, Cell Signaling, Cell Growth, Cell Metabolism, Endocrine, Neuroscience, Cardiovascular, Development, Aging, Development",scope:"Physiology, the scientific study of functions and mechanisms of living systems, is an essential area of research in its own right, but also in relation to medicine and health sciences. The scope of this topic will range from molecular, biochemical, cellular, and physiological processes in all animal species. Work pertaining to the whole organism, organ systems, individual organs and tissues, cells, and biomolecules will be included. Medical, animal, cell, and comparative physiology and allied fields such as anatomy, histology, and pathology with physiology links will be covered in this topic. 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Dr. Rutland also obtained an MMedSci (Medical Education) and a Postgraduate Certificate in Higher Education (PGCHE). She is the author of more than sixty peer-reviewed journal articles, twelve books/book chapters, and more than 100 research abstracts in cardiovascular biology and oncology. She is a board member of the European Association of Veterinary Anatomists, Fellow of the Anatomical Society, and Senior Fellow of the Higher Education Academy. 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