\\n\\n
These books synthesize perspectives of renowned scientists from the world’s most prestigious institutions - from Fukushima Renewable Energy Institute in Japan to Stanford University in the United States, including Columbia University (US), University of Sidney (AU), University of Miami (USA), Cardiff University (UK), and many others.
\\n\\nThis collaboration embodied the true essence of Open Access by simplifying the approach to OA publishing for Academic editors and authors who contributed their research and allowed the new research to be made available free and open to anyone anywhere in the world.
\\n\\nTo celebrate the 50 books published, we have gathered them at one location - just one click away, so that you can easily browse the subjects of your interest, download the content directly, share it or read online.
\\n\\n\\n\\n\\n"}]',published:!0,mainMedia:null},components:[{type:"htmlEditorComponent",content:'
IntechOpen and Knowledge Unlatched formed a partnership to support researchers working in engineering sciences by enabling an easier approach to publishing Open Access content. Using the Knowledge Unlatched crowdfunding model to raise the publishing costs through libraries around the world, Open Access Publishing Fee (OAPF) was not required from the authors.
\n\nInitially, the partnership supported engineering research, but it soon grew to include physical and life sciences, attracting more researchers to the advantages of Open Access publishing.
\n\n\n\nThese books synthesize perspectives of renowned scientists from the world’s most prestigious institutions - from Fukushima Renewable Energy Institute in Japan to Stanford University in the United States, including Columbia University (US), University of Sidney (AU), University of Miami (USA), Cardiff University (UK), and many others.
\n\nThis collaboration embodied the true essence of Open Access by simplifying the approach to OA publishing for Academic editors and authors who contributed their research and allowed the new research to be made available free and open to anyone anywhere in the world.
\n\nTo celebrate the 50 books published, we have gathered them at one location - just one click away, so that you can easily browse the subjects of your interest, download the content directly, share it or read online.
\n\n\n\n\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"3143",leadTitle:null,fullTitle:"The Mediterranean Genetic Code - Grapevine and Olive",title:"The Mediterranean Genetic Code",subtitle:"Grapevine and Olive",reviewType:"peer-reviewed",abstract:'The book "The Mediterranean Genetic Code - Grapevine and Olive" collects relevant papers documenting the results of research in grapevine and olive genetics, as a contribution to overall compendium of the existing biodiversity for both species with insight into molecular mechanisms responsible for their desirable and important traits. 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With team research becoming more prevalent across disciplines [1], there remain some unresolved issues. One unresolved issue is in conceptualizing or theorizing teams as complex adaptive systems (CAS; [1]). Even though this advancement in conceptualizing teams as CAS has started to gain momentum, empirical research has yet to catch up [1]. One advantage of viewing teams as CAS is that it better positions research and theory building efforts in a team’s natural setting, occurring closer to the phenomena [1]. Complex adaptive systems adapt and change due to environmental conditions thus making them dynamic and challenging to understand [2]. Due to this self-organizing adaptation, models of CAS are lacking and are “hard to formulate” [2]. Complex adaptive systems are also hard to comprehend in that these systems are not just the aggregate of the actions of the individual parts; it is the composite of the interactions of the parts [2]. deMattos et al. [3] expressed this by highlighting complexity as the result of “the inter-relationship, inter-action, and inter-connectivity of elements within a system”. To better understand CAS we must be able to understand how behaviors emerge from these interactions [2].
The composite of these interactions within CAS is often a function of leadership. Leadership in CAS is based on driving and facilitating these interactions. Leadership, in this perspective, “is about inter-action, influencing others, and encompasses a relationality that is dyadic and networked” [4]. Within CAS, leadership often takes the form of shared leadership in which individuals, or team members, share power and roles with other members based on task and situational demands [5]. Leadership for CAS has also been found in boundary spanning in which the leader establishes required interactions with team members and external agents when needed [5]. For each type of leadership style, leading in CAS requires a change in focus, redirecting the flow of practice toward new interactions and in new directions [4].
The current theoretical article provides a model for CAS by utilizing an existing team model, the Team Emergence Leadership Development and Evaluation (TELDE) model [6]. Identifying teams as CAS, the TELDE model helps to conceptualize the behaviors and interactions that take place in a team setting to understand, drive, and predict these emergent transformations. As emergent transformations are a response to environmental forces, teams are better able to adapt and share resources to achieve a new entity to better manage these new external changes, thus requiring leadership to also share roles and resources. The theoretical model presented in the current article utilizes naturally occurring team functions as the structure (TELDE) for CAS. Collectively, these CAS that utilize the TELDE model as its structure has the potential of scaling to the broader organizational, industrial, or community levels. The theoretical model presented here is titled Complex Adaptive Team Systems (CATS). The CATS model utilizes natural occurring team functions to drive more substantial organizational activities, such as the implementing knowledge management functions [7].
The style of theorizing for the current article is the narrative style of theorizing [8, 9]. The narrative style to theorizing is in response to recent calls from researchers to add more diversity to theory development styles that are currently published [8]. Also, the narrative style to theorizing is advantageous when the goal is to show patterns and to make broad connections, providing the ability to “see the big picture” [9].
The following sections provide a review of complexity theory and some of its key components. Next, a coverage of CAS is provided with a look at utilizing interactions as the level of analysis when viewing CAS. Finally, a review of the TELDE model is presented along with a model of CAS that utilizes the TELDE model and natural occurring team processes. This model, the Complex Adaptive Team System (CATS) model, provides the structure that organizations can implement when addressing today’s complexity.
Borzillo and Kaminska-Labbe [10] highlighted enabling leadership for communities of practice, indicating the role of leadership is to create situations that increase the social interactions of individuals. Here complexity theory addresses knowledge creation by facilitating the number of interactions or connections among agents. Within organizational settings and from a learning organization perspective, Borzillo and Kaminska-Labbe [10] identified the leaders’ role as being one that increases connectivity for the enhancement of cooperation and learning. Complexity theory has seen growth within the leadership literature: strategic leadership [11]; managerial leadership [12]; organizational leadership [13]; in viewing leadership as an
Anderson et al. [16] identified complexity in the interactions between individual parts of an open system and to the unpredictable patterns that emerged from these interactions. Antonacopoulou and Chiva [17] identified both interaction and inter-dependence processes across different levels (i.e., individual, team, department, organization) as being critical to emergence in complex systems. These functions highlight individual agents and their social structures as being synonymous with fractals, they have the potential to operate both as a part of the system and as a whole at the same time [17]. Understanding complexity and the systems that make up social complex systems is essential in making sense of the dynamics leading to the interactions, resulting in interdependence between agents or systems [17]. Complexity theory, or complexity science, is viewed as being one method to investigate the properties and behaviors of these non-linear dynamic systems [3].
A distinction between complex and chaos systems is in order. Complex systems are non-deterministic whereas chaos systems are deterministic [13], however both are non-linear systems. Non-deterministic systems provide no means of predicting future states while deterministic systems allow for prediction of future states. Complexity theory is:
Complexity theory is also useful for understanding nonlinear systems [13, 19, 20]. Similarly, complex systems have been described as exhibiting
Complexity theory provides a framework for understanding complex systems by identifying and recognizing the behaviors of interdependent, heterogeneous, and autonomous agents or systems. Here it is the patterns of the interactions from autonomous agents acting interdependently within a network or system that are under investigation [10]. Hunt et al. [12] identified emergence resulting from the interdependence of agents and their components. Hanseth and Lyytinen [24] placed complexity in the field of information technology (IT) as being related to increasing heterogeneous components and their relationships, dynamics, and interactions. Likewise, Uhl-Bien et al. [14] highlighted heterogeneous agents interacting in networks that produce patterns of behavior.
Bode and Wagner [25] defined complex systems as those with a variety of parts that interact in unpredictable ways. Expanding upon this definition, Bode and Wagner [25] separated complexity into two conceptualizations, structural and behavioral. Structural complexity related to the number and variety of the elements while dynamic complexity (behavioral) related to the interactions between the systems’ parts or elements [25]. Similarly, Mowles [26] identified three kinds of social problems when viewed from the lens of complexity theory: simple, complicated, and complex. Simple problems relate to those that can be solved using known recipes, complicated problems consist of many sub-problems that can be resolved collectively to solve a bigger problem, and complex problems have no recipe or formula with changing variables [26] and often require dynamic solutions as the problem’s variables change.
Anderson et al. [16] acknowledged that complex systems present a lack of predictability due to the interactions that take place among the components of a system. These interactions produce unexpected change compared to complicated systems that do not involve multiple and multi-level interactions within and among the system components, thus reducing the potential for systemic change from occurring. Complicated systems are predictable, and their components are either managed or designed to perform specific functions [16]. Bode and Wagner [25] identified that the more complex a system, the number of elements increase along with a rise in the number of potential interactions between the elements, resulting in a variety of different states that the system could exhibit at any one time.
Complex systems also produce higher levels of uncertainty or ambiguity. Mowles [26] identified four levels of uncertainty as being: a clear enough future, alternative future, a range of future, and true ambiguity. The latter levels of having either a range of futures or true ambiguity relate to the dynamics of complexity [26]. As the level of uncertainty and ambiguity increase, strategy requires processes to become intertwined [26] due to the interconnections and dynamism within the sub-systems [16]. As the level of complexity increases, it becomes more essential for leadership to be more distributed among agents of the CAS as no one individual can be expected to be an expert on all tasks and activities required of the CAS [27].
Different domains can emerge within the same system, organization, or institution given the right circumstances. Richardson [28] described a domain as an autonomous structure that is different from the whole, also identified as
While CAS (e.g., teams, organizations) operate between the state of equilibrium and disequilibrium, they may appear to be operating randomly. However, this false perception of random behavior is the emergence that “guides agent-based systems to potential new levels of collective behavior” [11]. Complex adaptive systems have been viewed as a
This concept of emergent domains can be both positive as well as negative. For example, teams are utilized in the workplace to perform functions that individuals are unable to do on their own. The resources, collective experience and knowledge, afforded by functional teams, aid in the team’s overall outcome. In some cases, this outcome is not only better than expected, but it can often be unexpected as well, making the team process one of emergence. Likewise, emergence can also be detrimental, making things more complicated. Take for example the concept of wicked problems. Aagaard [31] identified wicked problems developing through turbulent environments with continually changing expectations and solutions. These constant fluctuations present problems with ever–changing variables being derived based on the current environmental conditions, as environmental conditions change so to do the variables. These cyclical dynamics could be viewed as a form of emergence that reformulates a problem organically as environmental conditions fluctuate. Addressing wicked problems requires organizations and institutions to become more adaptive in their problem-solving methodologies [31]. Wicked problems have been viewed as being influenced by CAS where institutions, “such as nations, oil companies, and utilities are important actors” [32]. Traditional problem defining practices are not practical when addressing wicked problems. Here, one addresses wicked problems with an understanding of adaptability, emergence, and interconnectivity.
The function of self-organizing is a process [33], one in which the components of the system communicate with each other and cooperate in their coordinated efforts. This self-organizing process is critical to the emergence outcome, a co-creator of emergence [33]. Adaptability is vital in that self-organizing processes allow for systems to become adaptable and react to both external (environmental changes) and internal (organizational policies and processes) forces, leading closer to emergence. Also, this adaptability leads to a system being open and non-linear as compared to a closed and linear system. Chiva et al. [30] described adaptability as a “system’s capacity to adjust to changes in the environment without endangering its essential organizational features”. Adaptability is what differentiates closed systems from open systems; closed systems maintain the status quo while open systems adapt to external forces [34]. This distinction, between closed and open systems, is an important one. Closed systems can be self-organizing; however only open systems can be adaptive through self-organization without any external (managerial) intervention. However, there are times when an organization’s features do change after adaptability forces react, this is where emergence comes into play. Emergence changes the system’s structure to a new transformed structure allowing it to better adapt to external forces.
Organizations are complex systems made up of interdependent agents [11, 29] with overlapping functions. These complex systems can often be identified as networks, projects, hierarchies [31], teams, task forces, and departments to name only a few. Anderson et al. [16] identified entrepreneurship as being a complex system in which individual entrepreneurship efforts aggregate into the macroeconomy, with each micro process being unique, self-organizing, and different from the next. Alternatively, Aritua et al. [35] called on the profession of project management to develop new techniques and methodologies by viewing multi-projects as CAS. They identified one problem was with the field treating multi-projects as the aggregate of single project techniques and methodologies, which has not been very successful.
Complex adaptive systems are composed of individual actors acting interdependently, and autonomously [19], toward common goals. These CAS also learn through interactions and adapt behaviors based on this new knowledge [29], with the ability to evolve and self-organize [24]. Complex adaptive systems are the building blocks for higher level agents or systems (e.g., organizations, economies) while continuously adapting to environmental changes, called
Complex adaptive systems are responsive systems consisting of multiple agents that “cannot be created, designed or controlled by individual actors. But the system can be influenced, nurtured and exploited by a group of actors” [31]. This responsive aspect refers to the ability of the agents to act freely [16], interdependently [31], to learn and adapt [3, 29], and are linked dynamically [14]. Agents within CAS interact in response to internal and external threats, producing both complex and adaptive behavior patterns [11]. The interactivity among independent agents makes complex systems difficult to predict [36]. Patterns, or outcomes, are unpredictable and nonlinear [21] due to the nature of complexity involved and the interconnectivity across the sub-systems. Emergence results from these interactions in which a new system evolves from constant revising and rearranging the system components [33], providing the system with new capabilities of addressing internal and external threats.
The following definition for CAS will guide the theoretical model presented in the current research:
Complex adaptive systems, in its purest form, have been characterized as systems exhibiting characteristics of complexity theory [35]. For example, within the strategic management literature researchers identified the concept of strategic renewal as: “The incremental process through which an organization continuously adapts to the environment and explores opportunities to invoke change in its activity choices and outputs” [36]. As an evolutionary process, renewal occurs from relational exchanges (interactions) that provide organizations with systematic methods of addressing environmental change [37]. Strategic renewal views activity systems (e.g., CAS) from either an inertial view or from an adaptive view [36, 37]. The inertial view concentrates on the distribution of interdependencies (pattern) while the adaptive view focuses on information and resource flows (rules):
the interdependency pattern, the relative distribution of interdependencies among a focal firm’s activities, and
the interdependency rules, the prescriptive guidance of resource and information flows among interdependent activities [36].
Within the strategic management literature, it is the interdependency that enables strategic renewal in organizations [36]. Activity systems are complicated, in part due to their degree of modularity, concentration, and openness [36]. Modularity involves the number of subsystems within each system, concentration involves central control in one subsystem affecting other peripheral systems, and openness relates to one system’s dependency in making its own decisions, procedures, and policies separate from the other systems [36]. The more interdependent and interactive these components become, the more complex the system.
In the organizational learning literature, Antonacopoulou and Chiva [17] highlighted something similar to strategic renewal. They described the process of interdependence as a balancing act in which agents co-exist and co-evolve simultaneously. Interdependence allows processes to navigate between stability and change as part of an adaptive process. Complex adaptive systems have been identified as having the following essential components: “diversity and individuality of components, localized interactions among those components, and an autonomous process that uses the outcomes of those interactions to select a subset of those components for replication or enhancement” [3]. Similarly, Gregory et al. [38] and Hammer et al. [22] identified a total of 16 characteristics of CAS categorized into four facets: continuous varying interactions (CVI), patterns development (PD), people factors (PF), and self-organization (SO). The CVI facet involves types of interactions, the PD represents patterns that emerge from these interactions, the PF represents humans as social systems and, SO is constantly present in the background of the CAS [22].
Inter-relationships are common in social systems when taking a systems theory point of view. However, while systems theory mainly addresses closed and simple systems, complexity theory addresses complexity in open systems via CAS. In contrast to closed systems that do not interact with their external environment, open systems do. The more open a system becomes, the more it is affected by changes in its external environment. Just as individuals act in similar ways to those in proximity, the same could be said about other systems. Groups act similarly to other groups in proximity (i.e., organizational departments, executive boards), organizations act similarly to other organizations in proximity (i.e., industry, sector), communities act similarly to other communities in proximity (i.e., sister cities, smart cities), and so on. Emergence occurs when a set of individuals, as in a team setting, combine efforts to develop something positive, innovative, and unexpected. The same is true when multiple groups get together, when organizations get together, when governments get together, and so on. This perspective, that emergence can yield from interactions among collectives, has been highlighted in the literature: “Complex adaptive systems show that surprising and innovative behaviors can emerge from the interaction of groups of agents, seemingly without the necessity of centralized control” [11]. Although having a positive result is desired, negative results could also occur (i.e., riots, war), but the focus for the current article is on positive emergence. Feedback is a key component to any system, open or closed, in that it supports learning within the system and aids in identifying new properties when emergence occurs. Having the ability to adapt and learn is one primary characteristic of a CAS [3].
Open systems operating in complexity are, by definition, non-linear. Changes within and external of the system affect all other parts of the system in unpredictable (non-linear) ways. These non-linear states of dis-equilibrium do not behave randomly either; they operate on the edge of chaos [11]. With too much order the system tends to revert toward the original state of equilibrium, while too little order causes the system to potentially reach its undesirable state of chaos [39]. Given the right amount of complexity, systems can self-organize [39] and find their optimal balance.
Waldrop provided seven conditions that must be present for CAS:
A network of many agents acting in parallel.
Control is highly dispersed.
Coherent behavior in the system arising from competition and co-operation among the agents themselves.
Many levels of organization, with agents at one level serving as the building blocks for agents as a higher level.
Constant revising and rearranging of their building blocks as they gain experience.
Constant testing of its implicit or explicit assumptions about the way things are out there.
Exploitation of the many niches in the system by agents adapted to fill those niches [33].
These seven conditions [33] expand upon Holland’s [2] original conception of the essential components of CAS: parallelism, competition, and recombination. Other literature identified the following four critical characteristics of CAS as being; nonlinearity, order emerges from interactions, irreversibility, and unpredictable outcomes [24]. These four characteristics are described below:
nonlinearity, that is small changes in the input or the initial state can lead to order of magnitude differences in the output or the final state
order emerges from complex interactions
irreversibility of system states, that is, that change is path dependent; and
unpredictability of system outcomes. [24]
A leader facilitating the interactions that take place within and among CAS needs to begin at the individual level and work their way up to the organizational, industry, or network level, depending on the goal of the interaction or change initiative. This bottom-up approach is the desired approach when leading CAS. The following mechanisms are ways in which leadership can alter and support CAS. Leadership has the ability to alter:
the size of the system and the number of sub-units within it (N),
the interdependence among component units (K),
the collective schema of members (P), and
the interdependence of the system on others (C) [12].
Here, fostering and leading CAS is a function of the structure of the system, its interdependence, its collective cognitive structure, and its interdependence (f [N + K + P + C]). To facilitate the structure of a CAS the current research utilized Turner and Baker’s [6] TELDE model. Within the TELDE model the systems components act interdependently (K), team members develop collective cognitive structures (P), while operating interdependently (C) to obtain the team’s task. The size of the system and its sub-units (N), as identified by Hunt et al. [12], is a function of the number of TELDE models operating in succession. Collectively, the TELDE model along with the facilitating functions of [K + P + C] is presented in the following theoretical model as the Complex Adaptive Team System (CATS). The CATS model can be structured as a multi-team model or as a larger networking model, depending on the structure and the number of sub-units (TELDE models) in the CATS model. The CATS model provides a tool for organizations to recombine organizational resources, or to re-architect their business unit portfolios (40), when adapting to changing markets.
The following sections provide a review of Turner and Baker’s [6] TELDE model and its components, presents interactions as a new level of analysis for the CATS model, identifies the different CATS levels, discusses the role that leadership plays in implementing CATS, and places the CATS model in context (OL/LO, Organizational Change, Collective Cognitive Structures, Innovation, Cross-Business-Unit Collaborations).
The Team Emergence Leadership Development and Evaluation Model (TELDE) provides a visual representation of leadership development that derives natural, organic, leadership growth and team learning [6]. Typically, teams are not structured in a way that allow each group member to share in the team’s leadership role, provide feedback to other members during their leadership role, and reflect on their personal performance during their tenure as the team leader. While it is typical for team members to learn from other team members during teamwork (e.g., achieving the team’s tasks), it is rare for team members to learn both individually and collectively during these teamwork episodes (e.g., transition from one task to the next). Teams have historically consisted of a single leader with members relying on the leader for direction and guidance, this traditional model is still widely used today [11]. The TELDE model presents an approach in which each team member, regardless of rank within the organization, acts as the team leader for one of the team’s task-episodes (sub-task), ultimately resulting in all team members taking a leadership position while observing and providing feedback to other team members during their leadership tenure. This model provides the characteristic of “leadership development, team development, shared leadership, coaching, self-organizing and practice” [6], the characteristics of leadership development is also achieved by each team member by them taking a leadership role during one of the team’s task-episodes.
The model, as shown in Figure 1, illustrates a four-member team performing a project with four task-episodes (one task, four subtasks). The tasks are shown on the X-axis with the team members on the y-axis. As team member one takes ownership of his/her task and begins to drive it to completion, they are building their own leadership skills, as well as displaying leadership traits and characteristics for the rest of the team. As the first task concludes and team member two is taking over for the next task, a phenomenon known as transference occurs, where team member two is applying and growing in their own leadership capabilities by applying what they learned from team member one, further adapting to their own task situation. This same pattern continues for team members three and four, each member learning from the previous leader’s task achievement and eventually bringing the project to completion. At the height of each team member’s development there is a point known as leadership emergence [6]. This is the peak of adaptation to the leadership role and the high point of application of their new skills that the team members experience in their time as task leader.
The Team Emergence Leadership Development & Evaluation (TELDE) Model. Note: From Turner and Baker [
The TELDE model focused on leadership development at the individual level (team members) while addressing leadership as a group construct [6]. The TELDE model was presented as a model for organizational leadership development and leadership; however, this model has far-reaching potential in obtaining other organizational developmental objectives. This model could be implemented to achieve organizational change initiatives, to implement organizational culture interventions, as a means of adopting a new organizational policy, to training or onboarding new employees. The TELDE model’s utility is further expanded upon in the current research by incorporating it as the fundamental structure for the CATS model due to it being a CAS with individual agents working independently and interdependently toward a common goal while adapting and operating in a self-organizing manner toward emergence.
Complex adaptive systems are non-linear by definition, with an unlimited number of ways to abstract its processes. Richardson [28] highlighted this point by stating:
Richardson [28] continued by indicating that there is no one right abstraction or model when addressing non-linear models. Here, the only way to accurately model non-linear models, as in CAS, is to construct the CAS from the bottom up [28]. Rather than working backwards from some desired state of which we have limited knowledge [28], CAS should be addressed from what is known, the interactions that lead to complex patterns and emergence [12]. The function of leadership when operating in CAS is to foster and direct these interactions, leadership is inter-actional [4] through shared roles and responsibilities among the agents, resulting in a bottom-up process.
The CATS model takes the connectionist perspective for viewing, understanding, and predicting CAS. The level of analysis does not take place at either the macro level (i.e., team, department, organization) or the micro level (individual). The level of analysis identified here is new; it views the interactions between two independent agents within a system as a level of analysis worth considering. This dyadic event becomes the beginning of the overall process that leads toward emergence; thus, it should be considered as a means of better identifying and representing this process. The current article defines interactions as “the network of linkages across which information flows and connects” [14]. While the rules of engagement among individual agents in a system are critical factors of emergence in that individuals act to form these interactions, the individual and the interaction are considered two separate levels of analysis. The CATS model presents a theoretical model that provides an approach to understanding and guiding CAS. This theoretical model concentrates on the outcome that results from these interactions moving toward emergence rather than on the rules-based approach trying to understand the rules of engagement that led to these interactions.
This interaction level is believed to be the driving factor that fosters emergence that takes place in, and spans across, all levels, rather than the levels driving interaction. This interaction level is where leadership should focus a large portion of their efforts toward when operating in CAS. Concerning CAS, and more importantly to the CATS model, interactions that begin at the individual level within the TELDE model hold the potential to emerge into larger organizational, and even global, patterns.
As identified, it is the interaction between the agents of CATS that result in individual learning, the formation of new cognitive structures that contribute to emergent properties. Also, interactions among CATS produce much needed emergent properties; organizational learning and learning organization properties that allow organizations to better address wicked problems and to operate in today’s complex globalized environment. In viewing the level of analysis as the interaction, we identified four different CATS interaction levels: one to one/dyad, dyad to many/team, team to team/organization, and organization to network/industry. Figure 2 identifies each of these interaction levels.
Reciprocal Interactions at Various Organizational Levels.
Each of these four interaction levels consist of variations on micro- and macro-level perspectives. Micro-level represents the lower or smaller entity when compared to a higher or larger, macro entity. These micro- and macro-levels are utilized when representing multilevel models or theories. When a higher level affects a lower level, for example when new governmental regulations affect organizational policies, this process is identified as being top-down. Likewise, when a lower level affects a higher level as in poor employee engagement affecting organizational performance, this is identified as being a bottom-up process. Kozlowski and Klein [41] identified top-down processes as macro-levels exerting influence over micro-levels. Alternatively, bottom-up processes were defined as higher emergent properties that originated at lower levels [41]. In sum, top-down processes provide influence (e.g., mission statement, vision) while bottom-up processes have the potential of producing emergent properties. Because emergent properties come from bottom-up processes, and these processes are driven by the interactions among the agents involved, the focal point when addressing interactions as the level of analysis should be at bottom-up processes. However, even though the interactions and emergence come from bottom-up processes, the influence from the macro-level onto the micro-level (top-down) should not be disregarded. Both the bottom-up and the top-down processes should be considered in totality. This is depicted in Figure 2 by the arrows, an arrow from a micro-level to a macro-level represent emergent, bottom-up, processes. Likewise, an arrow from a macro-level to a micro-level represents influential, top-down, processes.
These levels of interaction are similar to the enabling functions identified by Uhl-Bien and Marion [15]. Their enabling functions began at the micro level (individual level) and aggregate into macro levels which, in turn, also affect the messo level. Figure 3 provides a representation of how these different interactions would take place within a single organization, inter-organizationally. In Figure 3, interactions take place at the individual level within each TELDE model, intra-team. Also, with multiple TELDE models operating sequentially (the CATS model) interactions take place across each team, inter-team to represent the macro-level.
CATS Model: Multiple TELDE Models Acting Inter-Organizationally.
In the inter-organizational model (Figure 3), each system (TELDE model) has peripheral influence over other, adjacent, systems. Here modularity is present as identified by [36].
The aggregate of the micro- and macro-level interactions, along with replication of the CATS model in additional organizations or entities, represents the messo-level interactions. These messo-level interactions are best represented in Figure 4 in which the CATS model is replicated, resulting in interactions inter-organizationally or across different networks (messo-level interactions). He et al. [42] provided one example of this when the researchers looked at how industrial clusters (CAS) formed, they formed through the interactions of the micro-organizations: “clusters form from micro-interactions and spontaneously evolve over time without any intervention”. These micro-interactions emerged across the micro-organizations and eventually influenced the formation of industrial clusters. In essence it is the initial dynamics that evolve into an organization’s adaptability [15], this set of interactive dynamics should be facilitated, not managed, by utilizing the CATS model.
CATS Model Intra-Organizationally or Across Networks (Globally).
The best way to manage CATS is to promote and flourish the interactions that take place within and between TELDE systems. Luoma [43] stressed that managers must be capable of leading in times of rapid change. Managements’ role within complex systems expands beyond traditional human relation functions to one that manages systems and networks [44]. Facilitating these interactions and acting as a change agent within such systems is another function of management. However, this function can only guide emergent processes and cannot control it due to its non-linear and non-predictable nature. A successful agent succeeds by triggering change to meet its own systemic needs [33]. Bovaird [33] identified this process as a
Organizations and systems are unable to remain in a state of equilibrium, successful organizations and systems avoid equilibrium [33] in favor of operating on the edge of chaos. Organizations should, due to this
Organizations need to view leadership as an emerging construct that facilitates self-organizing behavior to achieve desirable outcomes [20]. Leadership also needs to take a more integrated approach that accounts for both inter-system (e.g., inter-team, inter-organization, inter-network) and intra-system (e.g., intra-team, intra-organization, intra-network) dynamics [49]. Tong and Arvey [44] identified three managerial behaviors for leading in complexity; enabling, sensmaking, and facilitating shared leadership. Enabling behaviors allow leaders to enable adaptive outcomes rather than control them, sensmaking relates to a leader’s ability to identify what information is important and where a team’s attention needs to be focused, and facilitating shared leadership involves collective leadership compared to one overarching leader [44]. The CATS model enables members to adapt as needed, allowing the system to emerge in response to internal and external environmental forces. Sensemaking results in the collection of individual accounts [44], which is inherent in the CATS model. The CATS model provides the collective leadership needed in that it views the team as the leader in the TELDE model [6].
This transformation to a new leadership is in alignment with the
Antonacopoulou and Chiva [17] identified social complexity to highlight the need for learning in OL processes. They highlighted learning as being central to complexity because learning highlights the conditions of, and the outcomes from, interactions that fosters self-organizing activities which lead to emergence. Mowles [26] introduced this process as
Organizational change is often delayed due to four primary processes: structural, institutional, political, and learning processes [51]. The CATS model provides a model that potentially addresses all four delayed processes. The CATS model provides a structural model (structure) for driving organizational change as a bottom-up, self-organizing, process (learning) while achieving organizational and stakeholder objectives (institutional) in response to any environmental forces from the community, the government, or due to globalization (political).
Organizational change has been identified as occurring in cascades where change leads to additional change which, in turn, leads to even more change [51]. Here cascades occur within each TELDE model, ultimately resulting in organizational change through the aggregate from the CATS model.
At the network level, as shown in Figure 4, community ecology looks at the interdependence among differing organizations in which an organization’s legitimacy is related to its similarity and proximity to already legitimate organizations [52]. This network model, supported by the CATS model, provides a platform for collectives to structure similar cognitive spaces. This network model is representative of organizational interdependence models in that it provides interdependence between systems while also providing a proximate association. Organizational interdependence occurs at all levels of analysis; networks, populations, communities, global [52]. In addition to providing a model for organizational interdependence, identifying the interaction as the level of analysis for these network systems aid organizations, communities, and governments with a new architecture to facilitate global change. Further research is needed to test the CATS model to determine its impact on organizational change and organizational interdependence.
Learning within dynamic and complex systems, agents have the capability of being emergent and transformative [53], similar to the concept of transference in Turner and Baker’s [6] TELDE model. Through observation, practice, feedback, and reflection individual agents learn individually as well as collectively. This process was described by Boal and Schultz [11] as shared schemas where interactions lead to the development of similar cognitive structures or schemas. Likewise, Borzillo and Kaminska-Labbe [10] contrasted individual intelligence (interconnected neurons) with collective corporate intelligence (interconnectedness among agents). Turner et al. [54] identified similar team or group cognition models that explain how information is structured and processed collectively: shared mental models, SMM [55]; team mental models, TMM [56, 57]; information sharing, IS [58] transitive memory systems, TMS [59]; cognitive consensus, [60]; and group learning, [61, 62]. Using complexity science to understand corporate entrepreneurship strategy, Crawford and Kreiser [21] identified two organizational antecedents: “the
Chiva et al. [30] associated OL with competitive issues such as innovation. They identified innovation as involving new organizational processes along with more traditional concepts: new products, new services, and new knowledge [30]. Innovation is presented as being a collective construct, requiring the organization to learn and to develop new knowledge for the innovative product or process while, at the same time, learn from the innovative processes through feedback channels [30]. This reciprocal process includes both bottom-up and top-down processes at the same time. The CATS model needs to be tested to determine its impact on organizational innovation. The CATS model is one tool that could be utilized to manage innovative processes within organizations, providing self-organizing systems to be innovative (bottom-up) while addressing organizational problems (top-down).
Martin and Eisenhardt [40] introduced restructuring as one method for organizations to address changes in the market. One such effort is in cross-business-unit collaborations. Unfortunately, there is a lack of theoretical models and research addressing “how executives create high-performing cross-BU collaborations” [40]. Their research showed that executive decision-making was effective in multi-business settings when executives were part of a multibusiness team, acting collectively while consensually agreeing to decisions. These multibusiness teams act in a manner that is consistent with the TELDE model which could foster future research efforts. When these multibusiness teams operate across different businesses or industries, they act similarly to the CATS model. The CATS theory adds to the multibusiness organization literature by including a model that incorporates complexity theory and complex adaptive systems. Thus, making a fundamental contribution and meeting the requirements of a new theory [40].
The Columbia response effort began as “idiosyncratic local organizing actions” [29] among the participating agencies (i.e., NASA, FEMA, DOD, EPA). In order to respond quickly and to organize efforts between the multiple agencies that became involved, Beck and Plowman [29] identified four main categories that led to the successful collaborative efforts that came from the initial chaos:
Initial contextual conditions precipitated the collaborative effort.
The organizing actions taken by independent agencies.
The development of trust.
The development of a collective identity.
Success from the Columbia response effort resulted, not from any one agency being in charge, but from the in-charge agency (FEMA) acting as an enabler for the other agencies [29]. Their case study exemplified the support function from the host organization as a means for self-organization to take place. This support function included providing guidance, resources, and tools to the team/group as needed so they could complete their tasks. Also, the interactions that took place within the CAS were facilitated by the host organization. By providing the right direction and resources, the team/group could focus more attention on self-organizing activities aimed toward goal attainment, and in some cases, emergence. The agents involved in the Columbia response effort practiced an aggregated form of the CATS model in which agents acted interdependently toward one common goal that was facilitated by FEMA.
Complexity theory takes a different perspective when viewing systems. Rather than examining systems using reductionistic methods, complexity takes a connectionist perspective in understanding that emerging properties arise from the interactions among and between the system’s elements. As systems evolve from being complicated to being complex, typically by increases in the number of components and interactions within a system, CAS are formed requiring leadership to be distributed. Linearity is often associated with models that provide predictability and causal relationships [43] while CAS are associated with non-linearity, open systems, and non-predictablility. One method of facilitating and managing CAS is through the implementation of Turner and Baker’s [6] TELDE model. A CAS that utilizes the TELDE model as a means of driving change is known as the CATS model.
Micro-level activity and interactions aggregate, and eventually reflect higher-level activities [21]. This results in organizational outcomes being the result of micro-level adaptive and emergent forces through CAS and CATS. Crawford and Kreiser [21] explained: “Unless a new activity pattern emerges or is imposed by top-down tensions, the higher level aggregate activity will
Chiva et al. [30] presented innovation as introducing either new products, processes, markets, or organizational innovations. Organizational innovation involves incorporating new organizational methods, such as in implementing the TELDE model as the foundation of building CATS to drive organizational initiatives such as leadership development, new employee orientation, change initiatives, diversity training, organizational culture exercises, and new technology orientation, to only name a few. Today’s new leadership is best identified as being capable of influencing systems [12]. This influence comes, in part, through leaders’ managing the interactions between teams and agents as depicted in the CATS model. Leaders’ focusing on these interactions result in building connections and connecting agents, providing a new direction for leaders in today’s complexity: “What might get lost in leadership in the flow of practice is the basic connection (relationships) between the organizational agents” [4]. Utilizing and implementing CATS as standard practice to drive knowledge creation and innovation, and in making new connections within organizations, is one tool that is available for today’s leaders to operate in today’s complex and challenging environment.
The global consumption of energy and hydrocarbon-related commodities will continue to increase as the world population increases. The three sources of energy oil, gas, and coal are still dominating over 80% of the global energy matrix. However, natural gas is considered as the bridge fuel between the fossil fuel of today and the renewable fuel of tomorrow. It is cheap, more abundant than oil, and has lower CO2 emissions compared with oil and coal. These factors place natural gas, and by extension methane, as a principal candidate for replacing petroleum as a chemical feedstock and addressing various environmental issues. Natural gas is a flammable substance obtained from oil or gas fields and coal mines. At present, the confirmed natural gas reserves have a total volume of 187 trillion metric, of which 24.8% is found in the Middle East, 30.4% in Europe and Eurasia, 8.4% in the Asia Pacific region, 7.5% in Africa, 6.8% in North America and 4.1% in Middle and South America [1, 2, 3, 4, 5]. Natural gas is typically used as a fuel for power generation and for domestic heating. In 1971, global primary energy consumption was based on 48% oil, 29% coal and 18% natural gas. However, in 2015, the consumption of 13.1 billion tonnes (oil equivalent) of fuel was based on 33% oil, 30% coal and 24% natural gas [1], reflecting a shift from oil to natural gas. This transition from oil to natural gas consumption is expected to gradually increase until 2035 [1, 2, 3].
\nNatural gas resources are located in remote areas, and its utilisation is affected by high transportation costs. Therefore, conversion of natural gas to high value chemicals is the most promising solution. Methane and ethane are the main components of natural gas; they are stable and have no functional group, magnetic moment or polar distribution to facilitate chemical attacks. The C-H bonds of these light hydrocarbons are strong and require high reaction conditions to be activated.
\nOne of the most challenging processes in the chemical industry is the conversion of natural gas or methane to methanol, which is an important intermediate source of energy in our daily lives. Methanol can be used as a convenient energy storage material, a fuel, and a feedstock to synthesise hydrocarbons which mankind get from fossil fuel nowadays [2, 3] One of the importances of methanol comes from its direct use as a fuel or blending with gasoline to improve the octane number although it has half the volumetric energy density (15.6 MJ/L) relative to gasoline (34.2 MJ/L) and diesel (38.6 MJ/L) [4, 5, 6]. There had been 15,000 methanol-powered cars during the 1990s granted by the Environmental Protection Agency (EPA), but the use was discontinued due to an increased natural gas price [7]. Methanol is also a key feedstock for chemical manufacturing. The most major derivatives from methanol are formaldehyde, acetic acid, methyl tertiary butyl ether (MTBE) and dimethyl ether (DME). In recent years, methanol to hydrocarbons (MTH) research has been growing rapidly including methanol-to-gasoline (MTG) and methanol-to olefins (MTO) technology [8, 9, 10].
\nIn industries, an indirect route for the conversion of natural gas to methanol is used. In this reaction, methane is first converted to synthesis gas by steam reforming, and the synthesis gas is then converted to methanol. However, the production of syngas is an energy-intensive process, which is operated between 800 and 1000°C, and more than 25% of the feed (natural gas) has to be burned to provide the heat of reaction. The direct conversion of methane to methanol in a single step without going through the reforming step is a desired alternative to the current technology [2, 4, 5]. In spite of the fact that there are no actual plants yet for the process of direct methane to methanol (DMTM), previous experimental and theoretical works have demonstrated the feasibility of this route [2, 4, 5]. Here, this chapter will mainly focus on the recent efforts on the direct conversion of methane to oxygenates.
\nThis reaction is a free radical conducted under high temperature and pressure. The thermodynamic and kinetics studies identified the partial oxidation of methane as the rate limiting step due to the formation of methyl radical [7, 11]. Many studies with different oxidants have been conducted in this route. Babero et al. studied the partial oxidation of methane at 500 C temperature using nitrogen oxide as an oxidant [12]. Another study compared between oxygen and nitrogen oxide for the partial oxidation of methane in the gas phase [13]. The effect of adding small quantities of hydrocarbons such as ethane was investigated to promote the activation of methane and increase the selectivity of methanol [14]. Pressure is one of the most important factors which has a pronounced effect on the selectivity of methane oxidation. Dozens of studies have been performed in attempts to promote the selectivity toward oxygenates using high pressures and temperatures [8, 9, 15]. The results of these studies show that a conversion of 5–10% and a methanol yield of 30–40% can be achieved at a temperature of 723–773 K and pressures of 30–60 bar in the gas phase reaction. There are several works that investigated the reactor design and modifications. Zhang et al. designed a new tubular reactor based on quartz-line and stainless-steel line. The reaction was conducted at a temperature of 430–470°C and 5.0 Mpa pressure, and a high yield of methanol was obtained [9].
\nThe methane conversion to methanol was also conducted in the absence of catalysts at high reaction conditions. Methanol yields as high as 7–8% are obtained in the absence of catalysts operating at 350–500°C and 50 bar [10, 11, 16]. As reactor inertness is essential for obtaining good selectivity to methanol, the feed gas should be isolated from the metal wall by using quartz and Pyrex glass-lined reactors [17]. A typical experimental conversion-selectivity plot for the gas-phase partial oxidation of methane is shown in Figure 1 [18]. This plot ably demonstrates that any improvement in the direct conversion of methane to methanol must come from the enhancement of selectivity without reducing the conversion per pass. The Huels process uses cold-flame burners operating at 60 bar, with a selectivity of 71% to methanol and 14% to formaldehyde, and a recycle ratio of 200 to 1 [8].
\nHomogeneous gas-phase partial oxidation of methane from several studies: (1) Lott and Sliepcevich; (3) Tripathy; (4) Brockhaus; (6) Hunter; (8) Rytz and Baiker [
The suggested mechanism for the direct conversion of methane to methanol via homogeneous gas phase reactions is shown in Figure 2 [19].
\nSchematic diagram of the methane conversion via homogeneous gas phase reaction.
At moderate conditions, catalysts play an important role in the partial oxidation conversion of methane to methanol in terms of controlling the selectivity of the desired yield. Several catalysts have been investigated at 1 atm and mild temperatures.
\nIn homogeneous systems, in the early 1970s, it was shown that methane could be converted to methanol by Pt(II) and Pt(IV) complexes because these complexes do not oxidise CH3OH to COx [20]. Since that breakthrough, several oxidation catalysts based on Pt(II), Pd(II) and Hg(II) salts have been proven to functionalize C-H bonds [21, 22], leading to good yields of partially oxidised products (Eq. (1)). For example, [(2,2′-bipyrimidine)PtCl2] catalyses the selective oxidation of CH4 in fuming sulphuric acid to give methyl bisulphate in a 72% one-pass yield at 81% selectivity based on methane. Methyl bisulphate is then hydrolysed to methanol (Eq. (2)).
The major drawbacks of the liquid phase include not only the difficulty of separating the methanol product from the solvent but also solvents such as sulphuric acid need expensive corrosion-resistant materials and periodic regeneration of the consumed H2SO4. A new class of solid catalyst based on immobilised complexes has recently been reported for the direct low-temperature oxidation of methane to methanol [23]. This solid catalyst has a covalent triazine-based framework (CTF) with numerous accessible bipyridyl structure units, which should allow the coordination of platinum (Figure 3a and b) [23]. The performance of these new catalysts showed that the activity is maintained throughout several cycles, and selectivity for methanol formation above 75% could be reached.
\n(a) Bipyrimidyl Pt(II) complex used in the oxidation of methane to methyl bisulphate in concentrated sulphuric acid. (b) Covalent triazine-based framework (CTF) with numerous accessible bipyridyl structure units which are suitable to coordinate the Pt(II) complex.
In nature, methane monooxygenase enzymes (MMO) transform CH4 to CH3OH in water under ambient conditions [11]. A number of metal complexes have been proposed to mimic the chemistry of these enzymes [11, 24, 25], but the systems which generate active oxygen species capable of converting CH4 to CH3OH are yet to be created. In contrast to organometallic CH4 activation, MMO proceeds via a different mechanism by creating a very strong oxidising di-iron species able to attack a C-H bond in CH4. An essential feature of MMO is an active site containing two iron centres [11]. Metallophthalocyanines (MPc), and more specifically iron phthalocyanines (FePc), are good catalysts for clean oxidation processes. More specifically, FePc supported in μ-oxo dimeric form (Fe-O-Fe fragment) has better catalytic properties in CH4 conversion in the presence of hydrogen peroxide as an oxidant than its monomer counterpart (FePc). The heterolytic cleavage of the O-O bond in the FeIVNFeIIIOOH complex and the formation of very strong oxidising FeIVNFeV = O species are favoured in the presence of acid by the protonation of peroxide oxygen [11, 24, 25]. A new oxidation mechanism based on the use of metal clusters to harness the ‘singlet oxene’, the most reactive form of the oxygen atom, has recently been proposed [11, 26]. In this proposal, the key to oxygen insertion is a complex containing three copper atoms, in which the atomic charges vary. By synthesising a series of ligands to complex three copper atoms, mimicking the likely structure of the active site in pMMO, facile O-atom insertion into C-C and C-H bonds has been demonstrated in a number of simple organic substrates under ambient conditions of temperature and pressure. The ligands were designed to form the proper spatial and electronic geometry to harness a ‘singlet oxene’ [11, 25, 26]. It has been shown that the activity for methanol synthesis is 5 mol (CH3OH) kg (catalyst)−1 h−1 for sMMO as a complete enzyme with NADH present and this result represents the bench-market by which MMO catalysts should be judged. However, when NADH cofactor is removed, H2O2 can be used as the terminal oxidant with the enzyme but the catalytic activity decreases to 0.076 mol (CH3OH) h−1 kg (MMOH)−1 [27].
\nIn heterogeneous catalytic systems, many attempts have been conducted for the oxidation of methane. In most cases, SiO2 was used as a support with different metals, and O2 as oxidant. It was claimed that [28, 29] with a similar condition, HCHO might be produced with one-pass yield from 0 to 4%. However, high one pass HCHO yields were reported in some publications, but the results were not confirmed by other groups. It is stated that the results by different researchers have always been quite different, and some of them were even contradictory to one other [25, 30]. For instance, in one published work, a high selectivity (90%) to oxygenates (CH3OH + HCHO) was obtained at CH4 conversion of 20–25% at 873 K in an excess amount of water vapour over MoO3/SiO2 catalysts prepared by a sol-gel method [31]. Another work conducted the experiments under similar reactions with MoO3/SiO2 catalyst prepared by a similar method, but the yield of oxygenates was not greater than 4% [25]. Another example of contradiction showed that by using N2O as an oxidant, CH3OH could be achieved with a noticeable selectivity in the presence of H2O over MoO3/SiO2 [32]. Results published by other groups used similar catalytic systems, but the results showed no detectable formation of CH3OH [33, 34]. Metal-containing zeolites such as Co, Cu, and Fe have been studied at low temperature in batch mode [35, 36]. The direct conversion of methane to methanol over this metal-containing zeolite consists of three steps: (1) formation of active species by calcinations in air, (2) reaction of the active species with methane at low temperature and (3) extraction of methanol, using a polar protic solvent [37]. However, these catalytic systems are not yet a continuous process as an extraction procedure for methanol is required [36, 37]. A series of catalysts based on MoO3 and WO3 were studied, and the WO3-based catalysts were less effective for the production of methanol. The Ga2O3/MoO3 catalyst showed the maximum methanol yield [38].
\nIn a series of seminal publications, Hutchings and co-workers demonstrated that Fe-ZSM-5- and Fe-Cu-ZSM-5-based zeolites and Au-Pd supported on titania could activate methane at temperatures under 100°C using aqueous hydrogen peroxide as the terminal oxidant [39, 40]. The initial product of reaction was shown to be methyl hydroperoxide which subsequently reacted to yield methanol and formic acid. Figure 4 shows the time on line activity over Au-Pd/TiO2.
\nTime on line activity reaction temperature: 50°C, [H2O2]: 5000 μmol, solvent: H2O, 10 mL. Catalyst: 1.0 × 10−5 mol of metal, 28 mg 2.5 wt% Au-2.5 wt% Pd/TiO.
The turnover frequencies based on Fe were high with albeit very low conversions. More recently, Al-Shihri et al. [41] showed that the reaction pathway of oxidation in aqueous hydrogen peroxide over ZSM-5 catalysts followed the reaction sequence CH4 → CH3OOH → HCHO → formic acid. Although at the reaction conditions used the formaldehyde was oxidised rapidly to formic acid, it was also converted to low molecular weight polyoxomethylene polymer. Similar findings were achieved in preliminary results using Au-Pd catalysts. However, the use of aqueous hydrogen peroxide to oxidise methane is unlikely to prove economic unless its parallel catalysed decomposition into oxygen and H2O can be supressed. Thus, the development of a viable liquid phase process based on the use of aqueous hydrogen peroxide as the terminal oxidant would be challenging.
\nAn attractive alternative approach is to couple in situ direct generation of hydrogen peroxide from hydrogen and oxygen with methane oxidation in a tandem process. Au-Pd catalysts have proved to be highly active for the direct hydrogen peroxide synthesis reaction and capable of enhancing the tandem catalytic oxidation of alcohols, especially using nanostructured oxide supports [42, 43]. However, while the production rate of hydrogen peroxide is high, the achievable concentration in the liquid phase remains low due to the catalysed decomposition of the formed hydrogen peroxide. This means that a tandem process in the liquid phase is more likely to find application in the selective oxidation of high value chemicals. For direct selective oxidation of light hydrocarbons to oxygenated compounds, a gas phase continuous process based on the use of heterogeneous catalysts would be more attractive. In a tandem oxidation process, the oxidant would be oxygen, air or N2O mixed with hydrogen to generate surface hydroperoxy in situ by the surface reaction of hydrogen-oxygen.
\nIn a preliminary study, Al-Shihri et al. demonstrated that Au-Pd catalysts were able to catalyse the gas phase direct selective oxidation of methane at moderate conditions using the tandem synthesis of hydrogen peroxide from hydrogen-oxygen mixtures. The products of reaction were trapped and found to be methylhydroperoxide, polyoxomethylene, and a small amount of formic acid. Based on analogy with the liquid phase reaction sequence described above [41], the production of polyoxomethylene would be expected to involve initially the formation of formaldehyde as a reaction intermediate, although none was detected. This aspect is currently being investigated prior to publication of these exciting new results. The production of methyl hydroperoxide, formaldehyde and polyoxomethylene from methane is highly desirable. Polyoxomethylenes are valuable polymeric materials and also potential hydrogen storage materials; methyl hydroperoxide can be utilised to form methanol or react to form other compounds. In our preliminary study, the most promising Au-Pd catalysts were based on the use of nanostructured oxide supports. However, the catalysts were prepared by simple impregnation and were far from optimum in terms of metal particle dispersion and degree of Au-Pd alloy formation. These factors are important in the activity, selectivity, and maximising the selectivity in the use of the hydrogen, that is, avoiding direct combustion to water.
\nShan et al. showed that mononuclear rhodium species supported by zeolite or titanium dioxide in aqueous solution can convert methane to methanol and acetic acid with high selectivity, using oxygen and carbon monoxide under mild conditions [44]. In a recent study, the direct conversion of methane to methanol was investigated using experimental and computational study. The results of this study showed that low Ni loadings on a CeO2(111) support can perform a direct catalytic cycle for the generation of methanol at low temperature using oxygen and water as reactants, with a higher selectivity than ever reported for ceria-based catalysts [45].
\nGold-based catalysts have also shown interesting performance for the activation of C-H bond in alkane selective oxidation with dioxygen. A particular focus has been put on the synthesis of cyclohexanone and cyclohexanol. Zhao and co-workers [46] first applied gold catalysis in the activation of cyclohexane: Au/ZSM-5 and Au/MCM-41 favoured selectivity around 90% and conversions of 10–15% at 150°C, even though a loss in both activity and selectivity after their reuse is a drawback for industrial application. Two recent studies on the selective cyclohexane oxidation were performed by tailoring a supported gold on different materials, namely amorphous silica doped with titania and alumina prepared by a modified direct anionic exchange method [47].
\nIn the direct gas phase oxidation of methane to methanol, no noble metal except Pd was investigated, and there was no promising results obtained when Pd was used and that might be due to the excessive interaction between Pd and the supports [25, 48]. Therefore, in order to overcome the extent of interaction between Pd and the support, and to increase selectivity toward methanol, bimetallic systems seem to be a more promising solution. Great success has been achieved in a variety of catalytic processes by combining two metallic elements in bimetallic catalysts, such as the platinum-iridium (Pt-Ir) system for petroleum reforming, platinum-tin (Pt-Sn) for alkane dehydrogenation, the nickel-gold (Ni-Au) system for steam reforming of alkanes, and the palladium-gold (Pd-Au) for selective oxidations [49].
\nThe industrial production of methanol is executed via indirect way, in which methane is first converted to synthesise gas in highly intensive energy step. The synthesis gas is then converted to methanol. The intensive energy synthesis gas step occurs in operational plant at pressure range between 200 and 600 psi and temperature range between 700 and 1000°C [50]. This step is responsible for 60% of the capital cost of the plant. Therefore, the direct conversion of methane to methanol is highly desirable. Several approaches have been investigated and reported; however, no breakthrough has been achieved yet.
\nThe homogeneous gas phase partial oxidation has the potential to replace the industrial method. In a technical evaluation study of this method, it was shown that a methanol selectivity of over 70% at 15% methane conversion can be achieved. However, the low conversion of methane per pass and relatively low methanol selectivity is still observed in most of the academic reports [51, 52]. The problem is due to kinetic and thermodynamic reasons [53]. This way requires a pressure of around 10 atm and temperature (1000°C) to activate methane and convert it to methanol with reasonable selectivity. The C-H bond in methane (440 kJ/mol) is stronger than the same bond in methanol (389 kJ/mol). That means at high temperatures, the methanol is more reactive than methane, which might lead to the decomposition of methanol to low grade product [52, 54, 55, 56]. In addition, the gas phase homogeneous is a free radical reaction, which means that it is difficult to control the process on the large scale [51, 54, 57].
\nThe catalysts play an important role in activating methane at low reaction conditions and produce methanol with low byproducts [58, 59]. Two advantages of this method are the reduction of energy consumption used for methane conversion to methanol, and the low concentration of CO2 produced in this process [58, 59]. The important factor in this process is to find catalysts that could activate methane at moderate conditions and convert it selectively to methanol. Although intensive work has been reported, no catalytic system has achieved the target conversion and selectivity.
\nA low temperature homogeneous catalyst in solutions is another way to convert methane to methanol at low temperatures. However, two challenges of this method is first the introduction of the catalysts with reasonable reactivity and selectivity that also tolerates oxidising and protic conditions [11]. The second challenge is the use of acid as a solvent such as sulphuric acid, which is applied in many studies. The main disadvantage of using sulphuric acid as solvent is the difficulty in separating the methanol from the solvent. Moreover, the acid might corrode and poison the catalysts through the reaction [11].
\nIn nature, methane monooxygenases (MMOs) demonstrate high activity for methanol synthesis with a production rate of 5 mol (CH3OH) kg (catalyst)-1 h−1 at ambient conditions. However, this method is still not practical yet due to the difficulty in purifying these proteins and the further oxidation reaction of methanol to formaldehyde.
\nPlasma can be used in many applications including oxidation of methane to methanol [60]. In plasma, the oxidation of methane to methanol can be conducted under atmospheric gas pressure. Plasma is often referred to as the fourth state of matter, and it includes several components: positive ions, negative ions, electrons and neutral species. Plasma technology can be classified into thermal plasma and non-thermal plasma [61]. Thermal plasma can be described as a gas consisting of electrons, highly excited atoms, ions, radicals, photons and neutral particles, while electrons that have much higher energy than other surrounding particles populate non-thermal plasma. Okazaki et al. [62] reported that the conversion of methane to methanol was achieved using non-equilibrium plasma chemical reactions under atmospheric pressure by ultra-short pulsed barrier discharge in an extremely thin glass tube reactor. Various designs for plasma reactors for the oxidation of methane have been proposed to enhance the selectivity toward methanol. For example, in thermal plasma reactors, the dielectric barrier discharge (DBD) reactor was used for the synthesis of methanol from methane. This reactor was able to reduce the required temperature and pressure needed [63]. Another reactor is a new non-thermal discharge micro-reactor, which is used for a single-step, non-catalytic, direct and selective synthesis of methanol via methane partial oxidation at room temperature [64]. The non-thermal plasma can be developed by integrating the reactor with catalyst to improve the activity and selectivity of methane oxidation. In a recent study, the Cu-doped Ni was loaded on CeO2, which led to enhance the selectivity of methanol until 36% [65]. In another study, multicomponent catalysts were combined with plasma in two different approaches, in-plasma catalysis (IPC) and post-plasma catalysis (PPC), for achieving high levels in both methane conversion and aimed methanol selectivity through the synergetic effect of the Fe2O3\n−CuO/γ-Al2O3 catalyst [66].
\nThe photocatalytic process is a photochemical reaction that is carried out with external energy provided by ultraviolet light radiation that has energy equal to or greater than the energy band gap of a semiconductor. Several of oxidation and reduction processes are involved in the photo-generated electron and hole. TiO2 catalysts have been used as semiconductor photocatalysts for a wide range of environmental applications [67]. In addition, tungsten oxide (WO3) is also a good photocatalyst due to its high chemical stability in aqueous solution under acidic conditions in the presence of an oxidising agent [68]. For example, one study demonstrated that the WO3 photocatalyst produced hydroxyl radicals that react with a methane molecule to produce a methyl radical, which promote the formation of methanol [69]. Another study [70] investigated different experimental parameters for the methane conversion such as catalyst concentration, laser power, laser exposure time, effects of free radical generator (H2O2) and electron capture agent (Fe3+), using visible laser light. Also, this study examined the comparison between WO3 and TiO2, and it was found that the WO3 showed the highest methane conversion [70, 71]. A recent work has studied the introduction of some electron scavengers such as (Fe3+, Cu2+, and Ag+) and H2O2 species to the WO3 catalyst to enhance the selectivity of methanol. They found that WO3/Fe3+ is the most active catalyst with a methanol selectivity of 58.5% [68]. Another photocatalyst for the methane oxidation to methanol is vanadium oxide supported by MCM-41. Nitric oxide (NO) was used as an oxidant for the oxidation of methane under UV irradiation at 295 [72]. Figure 5 shows an example of methane conversion to methanol via photocatalysis.
\nGraphical representation of reaction of conversion of methane to methanol via photocatalysts [
The supercritical water oxidation (SCWO) is a reaction that occurs in water at elevated temperatures and pressures above the thermodynamic critical point of the mixture. Under the supercritical fluid conditions, the properties of water such as viscosity and dielectric constant can be adjusted between high gas-like diffusion rates and high liquid-like collision rates by varying pressure and temperature [60]. The catalytic oxidation of methane was examined over Cr2O3 under supercritical water conditions, and it was found that this catalytic system under supercritical conditions enhances the conversion rate of ethane and promotes the selectivity of methanol [74]. Another study investigated the isothermal conditions with a laminar reactor in SCWO for the direct partial oxidation of methane to methanol. They achieved a methanol selectivity of 35% at a conversion of 3% at temperatures of 400–410°C [75]. Savage PE et al., [76] have examined two types of reactors, glass-lined reactors and stainless steel reactors. A parametric study has been conducted using both reactors, and the glass lined reactor showed higher conversion of methane to methanol.
\nMembrane technology has been used for methane conversion to methanol using membrane reactor at moderate conditions. The advantage of using a membrane reactor is the fact that it can perform two functions at once, reaction and separation. The membrane can be classified based on the type of materials and porosity. The membrane can be made either by polymeric or organic materials with different porosity [60]. The organic membrane has advantages over the polymer in terms of the tolerance to chemical and temperature effects. Moreover, the organic membrane is mainly composed of metallic or ceramic materials and has greater physiochemical stability. Two research works studied the methane oxidation to produce methanol using Methylosinus trichosporium OB3b with a high concentration of Cu2+ and they found that the optimization of the conversion rate was positively affected by several parameters including the temperature, pH and concentrations of sodium formate, phosphate buffer and cyclopropanol [77, 78]. In another study, the methane oxidation was carried out using a membrane reactor where the methane and oxygen were introduced by two separate dense silicone tubes. A high methanol production of 1.12 g/L and 60% methane conversion were reported [79].
\nThe unconventional technologies such as plasma, photocatalysts, supercritical and biological are long-term processes, and still away from practical. The methane oxidation under plasma conditions is considered as a clean method as there are no harmful emissions produced such as CO2 and CO [80]. The plasma reactor is simple, benign and cheap. However, the productivity of methanol is low due to the limitation of methane solubility in the reaction medium at ambient conditions.
\nPhotocatalysis technology is an attractive way to convert methane to methanol, as the basic requirement for this method is the use of three abundant reactants of light, water and methane. Despite the two decades of work on photocatalysis, the selectivity of methanol is still low [68, 70].
\nSupercritical water oxidation is an efficient process to treat a variety of hazardous and non-hazardous wastes. However, there are some factors that limit the application of this technology in methane oxidation such as the complication of the reactor design, the high temperature used and the high corrosion rate when using halogens such as chlorine for some waste treatment [60, 81].
\nThe use of membrane technology for methane conversion to methanol is feasible due to the advantage of the effective separation of methane and methanol. However, some challenges still exist for large scale application: first, the relatively high energy requirement for large scale plant, second, the low tolerance of polymer-based membrane to high temperatures and chemicals, third, the high conversion of methane will produce different organic compounds, and that might cause swelling or breakage of the membrane [60, 81].
\nIn this chapter, we discussed the utilisation of methane as the main component of natural gas that can be converted to methanol. We discussed various processes that can activate methane and convert it in a single step to methanol, including their feasibility, recent progress and challenges associated with the conventional and unconventional methods. We showed that these processes have advantages and disadvantages. However, most of them suffer from the low yield of methanol. The unconventional methods are long-term processes and still far away from practical. The low temperature route using heterogeneous catalysts has a great potential and can be alternative to the current industrial process as some catalytic systems were shown to activate methane at moderate reaction conditions using different oxidants. Nevertheless, the selectivity toward methanol is still low. Therefore, more effort is needed to design and synthesise robust and cheap catalysts that could convert methane directly and selectively to methanol using air as an oxidant in a continuous flow reaction system.
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He is currently an Assistant Professor with the University of British Colombia, Canada.",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",institutionURL:null,country:{name:"Canada"}}}]}]},openForSubmissionBooks:{paginationCount:3,paginationItems:[{id:"11580",title:"Recent Advances in Canine Medicine",coverURL:"https://cdn.intechopen.com/books/images_new/11580.jpg",hash:"1806716f60b9be14fc05682c4a912b41",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"March 23rd 2022",isOpenForSubmission:!0,editors:[{id:"258334",title:"Dr.",name:"Carlos Eduardo",surname:"Fonseca-Alves",slug:"carlos-eduardo-fonseca-alves",fullName:"Carlos Eduardo Fonseca-Alves"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11579",title:"Animal Welfare - New Insights",coverURL:"https://cdn.intechopen.com/books/images_new/11579.jpg",hash:"12e4f41264cbe99028655e5463fa941a",secondStepPassed:!1,currentStepOfPublishingProcess:2,submissionDeadline:"June 1st 2022",isOpenForSubmission:!0,editors:[{id:"51520",title:"Dr.",name:"Shao-Wen",surname:"Hung",slug:"shao-wen-hung",fullName:"Shao-Wen Hung"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11578",title:"Antibiotics and Probiotics in Animal Food - Impact and Regulation",coverURL:"https://cdn.intechopen.com/books/images_new/11578.jpg",hash:"3731c009f474c6ed4293f348ca7b27ac",secondStepPassed:!1,currentStepOfPublishingProcess:2,submissionDeadline:"June 3rd 2022",isOpenForSubmission:!0,editors:[{id:"225390",title:"Dr.",name:"Asghar Ali",surname:"Kamboh",slug:"asghar-ali-kamboh",fullName:"Asghar Ali Kamboh"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},onlineFirstChapters:{paginationCount:1,paginationItems:[{id:"81831",title:"Deep Network Model and Regression Analysis using OLS Method for Predicting Lung Vital Capacity",doi:"10.5772/intechopen.104737",signatures:"Harun Sümbül",slug:"deep-network-model-and-regression-analysis-using-ols-method-for-predicting-lung-vital-capacity",totalDownloads:0,totalCrossrefCites:null,totalDimensionsCites:0,authors:null,book:{title:"Decision Science - Recent Advances and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/11604.jpg",subseries:{id:"86",title:"Business and Management"}}}]},subseriesFiltersForOFChapters:[{caption:"Business and Management",value:86,count:1,group:"subseries"}],publishedBooks:{paginationCount:1,paginationItems:[{type:"book",id:"11392",title:"Leadership in a Changing World",subtitle:"A Multidimensional Perspective",coverURL:"https://cdn.intechopen.com/books/images_new/11392.jpg",slug:"leadership-in-a-changing-world-a-multidimensional-perspective",publishedDate:"May 11th 2022",editedByType:"Edited by",bookSignature:"Muhammad Mohiuddin, Bilal Khalid, Md. Samim Al Azad and Slimane Ed-dafali",hash:"86a6d33cf601587e591064ce92effc02",volumeInSeries:1,fullTitle:"Leadership in a Changing World - A Multidimensional Perspective",editors:[{id:"418514",title:"Dr.",name:"Muhammad",middleName:null,surname:"Mohiuddin",slug:"muhammad-mohiuddin",fullName:"Muhammad Mohiuddin",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038UqSfQAK/Profile_Picture_2022-05-13T10:39:03.jpg",institutionString:null,institution:{name:"Université Laval",institutionURL:null,country:{name:"Canada"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Business and Management",value:86,count:1}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:1}],authors:{paginationCount:249,paginationItems:[{id:"274452",title:"Dr.",name:"Yousif",middleName:"Mohamed",surname:"Abdallah",slug:"yousif-abdallah",fullName:"Yousif Abdallah",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/274452/images/8324_n.jpg",biography:"I certainly enjoyed my experience in Radiotherapy and Nuclear Medicine, particularly it has been in different institutions and hospitals with different Medical Cultures and allocated resources. Radiotherapy and Nuclear Medicine Technology has always been my aspiration and my life. As years passed I accumulated a tremendous amount of skills and knowledge in Radiotherapy and Nuclear Medicine, Conventional Radiology, Radiation Protection, Bioinformatics Technology, PACS, Image processing, clinically and lecturing that will enable me to provide a valuable service to the community as a Researcher and Consultant in this field. My method of translating this into day to day in clinical practice is non-exhaustible and my habit of exchanging knowledge and expertise with others in those fields is the code and secret of success.",institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"313277",title:"Dr.",name:"Bartłomiej",middleName:null,surname:"Płaczek",slug:"bartlomiej-placzek",fullName:"Bartłomiej Płaczek",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/313277/images/system/313277.jpg",biography:"Bartłomiej Płaczek, MSc (2002), Ph.D. (2005), Habilitation (2016), is a professor at the University of Silesia, Institute of Computer Science, Poland, and an expert from the National Centre for Research and Development. His research interests include sensor networks, smart sensors, intelligent systems, and image processing with applications in healthcare and medicine. He is the author or co-author of more than seventy papers in peer-reviewed journals and conferences as well as the co-author of several books. He serves as a reviewer for many scientific journals, international conferences, and research foundations. Since 2010, Dr. Placzek has been a reviewer of grants and projects (including EU projects) in the field of information technologies.",institutionString:"University of Silesia",institution:{name:"University of Silesia",country:{name:"Poland"}}},{id:"35000",title:"Prof.",name:"Ulrich H.P",middleName:"H.P.",surname:"Fischer",slug:"ulrich-h.p-fischer",fullName:"Ulrich H.P Fischer",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/35000/images/3052_n.jpg",biography:"Academic and Professional Background\nUlrich H. P. has Diploma and PhD degrees in Physics from the Free University Berlin, Germany. He has been working on research positions in the Heinrich-Hertz-Institute in Germany. Several international research projects has been performed with European partners from France, Netherlands, Norway and the UK. He is currently Professor of Communications Systems at the Harz University of Applied Sciences, Germany.\n\nPublications and Publishing\nHe has edited one book, a special interest book about ‘Optoelectronic Packaging’ (VDE, Berlin, Germany), and has published over 100 papers and is owner of several international patents for WDM over POF key elements.\n\nKey Research and Consulting Interests\nUlrich’s research activity has always been related to Spectroscopy and Optical Communications Technology. Specific current interests include the validation of complex instruments, and the application of VR technology to the development and testing of measurement systems. He has been reviewer for several publications of the Optical Society of America\\'s including Photonics Technology Letters and Applied Optics.\n\nPersonal Interests\nThese include motor cycling in a very relaxed manner and performing martial arts.",institutionString:null,institution:{name:"Charité",country:{name:"Germany"}}},{id:"341622",title:"Ph.D.",name:"Eduardo",middleName:null,surname:"Rojas Alvarez",slug:"eduardo-rojas-alvarez",fullName:"Eduardo Rojas Alvarez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/341622/images/15892_n.jpg",biography:null,institutionString:null,institution:{name:"University of Cuenca",country:{name:"Ecuador"}}},{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/215610/images/system/215610.jpeg",biography:"Muhammad Sarfraz is a professor in the Department of Information Science, Kuwait University, Kuwait. His research interests include optimization, computer graphics, computer vision, image processing, machine learning, pattern recognition, soft computing, data science, and intelligent systems. Prof. Sarfraz has been a keynote/invited speaker at various platforms around the globe. He has advised/supervised more than 110 students for their MSc and Ph.D. theses. He has published more than 400 publications as books, journal articles, and conference papers. He has authored and/or edited around seventy books. Prof. Sarfraz is a member of various professional societies. He is a chair and member of international advisory committees and organizing committees of numerous international conferences. He is also an editor and editor in chief for various international journals.",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"32650",title:"Prof.",name:"Lukas",middleName:"Willem",surname:"Snyman",slug:"lukas-snyman",fullName:"Lukas Snyman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/32650/images/4136_n.jpg",biography:"Lukas Willem Snyman received his basic education at primary and high schools in South Africa, Eastern Cape. He enrolled at today's Nelson Metropolitan University and graduated from this university with a BSc in Physics and Mathematics, B.Sc Honors in Physics, MSc in Semiconductor Physics, and a Ph.D. in Semiconductor Physics in 1987. After his studies, he chose an academic career and devoted his energy to the teaching of physics to first, second, and third-year students. After positions as a lecturer at the University of Port Elizabeth, he accepted a position as Associate Professor at the University of Pretoria, South Africa.\r\n\r\nIn 1992, he motivates the concept of 'television and computer-based education” as means to reach large student numbers with only the best of teaching expertise and publishes an article on the concept in the SA Journal of Higher Education of 1993 (and later in 2003). The University of Pretoria subsequently approved a series of test projects on the concept with outreach to Mamelodi and Eerste Rust in 1993. In 1994, the University established a 'Unit for Telematic Education ' as a support section for multiple faculties at the University of Pretoria. In subsequent years, the concept of 'telematic education” subsequently becomes well established in academic circles in South Africa, grew in popularity, and is adopted by many universities and colleges throughout South Africa as a medium of enhancing education and training, as a method to reaching out to far out communities, and as a means to enhance study from the home environment.\r\n\r\nProfessor Snyman in subsequent years pursued research in semiconductor physics, semiconductor devices, microelectronics, and optoelectronics.\r\n\r\nIn 2000 he joined the TUT as a full professor. Here served for a period as head of the Department of Electronic Engineering. Here he makes contributions to solar energy development, microwave and optoelectronic device development, silicon photonics, as well as contributions to new mobile telecommunication systems and network planning in SA.\r\n\r\nCurrently, he teaches electronics and telecommunications at the TUT to audiences ranging from first-year students to Ph.D. level.\r\n\r\nFor his research in the field of 'Silicon Photonics” since 1990, he has published (as author and co-author) about thirty internationally reviewed articles in scientific journals, contributed to more than forty international conferences, about 25 South African provisional patents (as inventor and co-inventor), 8 PCT international patent applications until now. Of these, two USA patents applications, two European Patents, two Korean patents, and ten SA patents have been granted. A further 4 USA patents, 5 European patents, 3 Korean patents, 3 Chinese patents, and 3 Japanese patents are currently under consideration.\r\n\r\nRecently he has also published an extensive scholarly chapter in an internet open access book on 'Integrating Microphotonic Systems and MOEMS into standard Silicon CMOS Integrated circuitry”.\r\n\r\nFurthermore, Professor Snyman recently steered a new initiative at the TUT by introducing a 'Laboratory for Innovative Electronic Systems ' at the Department of Electrical Engineering. The model of this laboratory or center is to primarily combine outputs as achieved by high-level research with lower-level system development and entrepreneurship in a technical university environment. Students are allocated to projects at different levels with PhDs and Master students allocated to the generation of new knowledge and new technologies, while students at the diploma and Baccalaureus level are allocated to electronic systems development with a direct and a near application for application in industry or the commercial and public sectors in South Africa.\r\n\r\nProfessor Snyman received the WIRSAM Award of 1983 and the WIRSAM Award in 1985 in South Africa for best research papers by a young scientist at two international conferences on electron microscopy in South Africa. He subsequently received the SA Microelectronics Award for the best dissertation emanating from studies executed at a South African university in the field of Physics and Microelectronics in South Africa in 1987. In October of 2011, Professor Snyman received the prestigious Institutional Award for 'Innovator of the Year” for 2010 at the Tshwane University of Technology, South Africa. This award was based on the number of patents recognized and granted by local and international institutions as well as for his contributions concerning innovation at the TUT.",institutionString:null,institution:{name:"University of South Africa",country:{name:"South Africa"}}},{id:"317279",title:"Mr.",name:"Ali",middleName:"Usama",surname:"Syed",slug:"ali-syed",fullName:"Ali Syed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/317279/images/16024_n.png",biography:"A creative, talented, and innovative young professional who is dedicated, well organized, and capable research fellow with two years of experience in graduate-level research, published in engineering journals and book, with related expertise in Bio-robotics, equally passionate about the aesthetics of the mechanical and electronic system, obtained expertise in the use of MS Office, MATLAB, SolidWorks, LabVIEW, Proteus, Fusion 360, having a grasp on python, C++ and assembly language, possess proven ability in acquiring research grants, previous appointments with social and educational societies with experience in administration, current affiliations with IEEE and Web of Science, a confident presenter at conferences and teacher in classrooms, able to explain complex information to audiences of all levels.",institutionString:null,institution:{name:"Air University",country:{name:"Pakistan"}}},{id:"75526",title:"Ph.D.",name:"Zihni Onur",middleName:null,surname:"Uygun",slug:"zihni-onur-uygun",fullName:"Zihni Onur Uygun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/75526/images/12_n.jpg",biography:"My undergraduate education and my Master of Science educations at Ege University and at Çanakkale Onsekiz Mart University have given me a firm foundation in Biochemistry, Analytical Chemistry, Biosensors, Bioelectronics, Physical Chemistry and Medicine. After obtaining my degree as a MSc in analytical chemistry, I started working as a research assistant in Ege University Medical Faculty in 2014. In parallel, I enrolled to the MSc program at the Department of Medical Biochemistry at Ege University to gain deeper knowledge on medical and biochemical sciences as well as clinical chemistry in 2014. In my PhD I deeply researched on biosensors and bioelectronics and finished in 2020. Now I have eleven SCI-Expanded Index published papers, 6 international book chapters, referee assignments for different SCIE journals, one international patent pending, several international awards, projects and bursaries. In parallel to my research assistant position at Ege University Medical Faculty, Department of Medical Biochemistry, in April 2016, I also founded a Start-Up Company (Denosens Biotechnology LTD) by the support of The Scientific and Technological Research Council of Turkey. Currently, I am also working as a CEO in Denosens Biotechnology. The main purposes of the company, which carries out R&D as a research center, are to develop new generation biosensors and sensors for both point-of-care diagnostics; such as glucose, lactate, cholesterol and cancer biomarker detections. My specific experimental and instrumental skills are Biochemistry, Biosensor, Analytical Chemistry, Electrochemistry, Mobile phone based point-of-care diagnostic device, POCTs and Patient interface designs, HPLC, Tandem Mass Spectrometry, Spectrophotometry, ELISA.",institutionString:null,institution:{name:"Ege University",country:{name:"Turkey"}}},{id:"246502",title:"Dr.",name:"Jaya T.",middleName:"T",surname:"Varkey",slug:"jaya-t.-varkey",fullName:"Jaya T. Varkey",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246502/images/11160_n.jpg",biography:"Jaya T. Varkey, PhD, graduated with a degree in Chemistry from Cochin University of Science and Technology, Kerala, India. She obtained a PhD in Chemistry from the School of Chemical Sciences, Mahatma Gandhi University, Kerala, India, and completed a post-doctoral fellowship at the University of Minnesota, USA. She is a research guide at Mahatma Gandhi University and Associate Professor in Chemistry, St. Teresa’s College, Kochi, Kerala, India.\nDr. Varkey received a National Young Scientist award from the Indian Science Congress (1995), a UGC Research award (2016–2018), an Indian National Science Academy (INSA) Visiting Scientist award (2018–2019), and a Best Innovative Faculty award from the All India Association for Christian Higher Education (AIACHE) (2019). She Hashas received the Sr. Mary Cecil prize for best research paper three times. She was also awarded a start-up to develop a tea bag water filter. \nDr. Varkey has published two international books and twenty-seven international journal publications. She is an editorial board member for five international journals.",institutionString:"St. Teresa’s College",institution:null},{id:"250668",title:"Dr.",name:"Ali",middleName:null,surname:"Nabipour Chakoli",slug:"ali-nabipour-chakoli",fullName:"Ali Nabipour Chakoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/250668/images/system/250668.jpg",biography:"Academic Qualification:\r\n•\tPhD in Materials Physics and Chemistry, From: Sep. 2006, to: Sep. 2010, School of Materials Science and Engineering, Harbin Institute of Technology, Thesis: Structure and Shape Memory Effect of Functionalized MWCNTs/poly (L-lactide-co-ε-caprolactone) Nanocomposites. Supervisor: Prof. Wei Cai,\r\n•\tM.Sc in Applied Physics, From: 1996, to: 1998, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Determination of Boron in Micro alloy Steels with solid state nuclear track detectors by neutron induced auto radiography, Supervisors: Dr. M. Hosseini Ashrafi and Dr. A. Hosseini.\r\n•\tB.Sc. in Applied Physics, From: 1991, to: 1996, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Design of shielding for Am-Be neutron sources for In Vivo neutron activation analysis, Supervisor: Dr. M. Hosseini Ashrafi.\r\n\r\nResearch Experiences:\r\n1.\tNanomaterials, Carbon Nanotubes, Graphene: Synthesis, Functionalization and Characterization,\r\n2.\tMWCNTs/Polymer Composites: Fabrication and Characterization, \r\n3.\tShape Memory Polymers, Biodegradable Polymers, ORC, Collagen,\r\n4.\tMaterials Analysis and Characterizations: TEM, SEM, XPS, FT-IR, Raman, DSC, DMA, TGA, XRD, GPC, Fluoroscopy, \r\n5.\tInteraction of Radiation with Mater, Nuclear Safety and Security, NDT(RT),\r\n6.\tRadiation Detectors, Calibration (SSDL),\r\n7.\tCompleted IAEA e-learning Courses:\r\nNuclear Security (15 Modules),\r\nNuclear Safety:\r\nTSA 2: Regulatory Protection in Occupational Exposure,\r\nTips & Tricks: Radiation Protection in Radiography,\r\nSafety and Quality in Radiotherapy,\r\nCourse on Sealed Radioactive Sources,\r\nCourse on Fundamentals of Environmental Remediation,\r\nCourse on Planning for Environmental Remediation,\r\nKnowledge Management Orientation Course,\r\nFood Irradiation - Technology, Applications and Good Practices,\r\nEmployment:\r\nFrom 2010 to now: Academic staff, Nuclear Science and Technology Research Institute, Kargar Shomali, Tehran, Iran, P.O. Box: 14395-836.\r\nFrom 1997 to 2006: Expert of Materials Analysis and Characterization. Research Center of Agriculture and Medicine. Rajaeeshahr, Karaj, Iran, P. O. Box: 31585-498.",institutionString:"Atomic Energy Organization of Iran",institution:{name:"Atomic Energy Organization of Iran",country:{name:"Iran"}}},{id:"248279",title:"Dr.",name:"Monika",middleName:"Elzbieta",surname:"Machoy",slug:"monika-machoy",fullName:"Monika Machoy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248279/images/system/248279.jpeg",biography:"Monika Elżbieta Machoy, MD, graduated with distinction from the Faculty of Medicine and Dentistry at the Pomeranian Medical University in 2009, defended her PhD thesis with summa cum laude in 2016 and is currently employed as a researcher at the Department of Orthodontics of the Pomeranian Medical University. She expanded her professional knowledge during a one-year scholarship program at the Ernst Moritz Arndt University in Greifswald, Germany and during a three-year internship at the Technical University in Dresden, Germany. She has been a speaker at numerous orthodontic conferences, among others, American Association of Orthodontics, European Orthodontic Symposium and numerous conferences of the Polish Orthodontic Society. She conducts research focusing on the effect of orthodontic treatment on dental and periodontal tissues and the causes of pain in orthodontic patients.",institutionString:"Pomeranian Medical University",institution:{name:"Pomeranian Medical University",country:{name:"Poland"}}},{id:"252743",title:"Prof.",name:"Aswini",middleName:"Kumar",surname:"Kar",slug:"aswini-kar",fullName:"Aswini Kar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252743/images/10381_n.jpg",biography:"uploaded in cv",institutionString:null,institution:{name:"KIIT University",country:{name:"India"}}},{id:"204256",title:"Dr.",name:"Anil",middleName:"Kumar",surname:"Kumar Sahu",slug:"anil-kumar-sahu",fullName:"Anil Kumar Sahu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204256/images/14201_n.jpg",biography:"I have nearly 11 years of research and teaching experience. I have done my master degree from University Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur, Chhattisgarh India. I have published 16 review and research articles in international and national journals and published 4 chapters in IntechOpen, the world’s leading publisher of Open access books. I have presented many papers at national and international conferences. I have received research award from Indian Drug Manufacturers Association in year 2015. My research interest extends from novel lymphatic drug delivery systems, oral delivery system for herbal bioactive to formulation optimization.",institutionString:null,institution:{name:"Chhattisgarh Swami Vivekanand Technical University",country:{name:"India"}}},{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",biography:"An assistant professor at Department of Biomedical Computer Systems, at Institute of Computer Science, Silesian University in Katowice. Scientific interests: computer analysis and processing of images, biomedical images, databases and programming languages. He is an author and co-author of scientific publications covering analysis and processing of biomedical images and development of database systems.",institutionString:"University of Silesia",institution:null},{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",biography:"Dr. Hadi Mohammadi is a biomedical engineer with hands-on experience in the design and development of many engineering structures and medical devices through various projects that he has been involved in over the past twenty years. Dr. Mohammadi received his BSc. and MSc. degrees in Mechanical Engineering from Sharif University of Technology, Tehran, Iran, and his PhD. degree in Biomedical Engineering (biomaterials) from the University of Western Ontario. He was a postdoctoral trainee for almost four years at University of Calgary and Harvard Medical School. He is an industry innovator having created the technology to produce lifelike synthetic platforms that can be used for the simulation of almost all cardiovascular reconstructive surgeries. He’s been heavily involved in the design and development of cardiovascular devices and technology for the past 10 years. He is currently an Assistant Professor with the University of British Colombia, Canada.",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",country:{name:"Canada"}}},{id:"254463",title:"Prof.",name:"Haisheng",middleName:null,surname:"Yang",slug:"haisheng-yang",fullName:"Haisheng Yang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/254463/images/system/254463.jpeg",biography:"Haisheng Yang, Ph.D., Professor and Director of the Department of Biomedical Engineering, College of Life Science and Bioengineering, Beijing University of Technology. He received his Ph.D. degree in Mechanics/Biomechanics from Harbin Institute of Technology (jointly with University of California, Berkeley). Afterwards, he worked as a Postdoctoral Research Associate in the Purdue Musculoskeletal Biology and Mechanics Lab at the Department of Basic Medical Sciences, Purdue University, USA. He also conducted research in the Research Centre of Shriners Hospitals for Children-Canada at McGill University, Canada. Dr. Yang has over 10 years research experience in orthopaedic biomechanics and mechanobiology of bone adaptation and regeneration. He earned an award from Beijing Overseas Talents Aggregation program in 2017 and serves as Beijing Distinguished Professor.",institutionString:"Beijing University of Technology",institution:null},{id:"255757",title:"Dr.",name:"Igor",middleName:"Victorovich",surname:"Lakhno",slug:"igor-lakhno",fullName:"Igor Lakhno",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255757/images/system/255757.jpg",biography:"Lakhno Igor Victorovich was born in 1971 in Kharkiv (Ukraine). \nMD – 1994, Kharkiv National Medical Univesity.\nOb&Gyn; – 1997, master courses in Kharkiv Medical Academy of Postgraduate Education.\nPhD – 1999, Kharkiv National Medical Univesity.\nDSc – 2019, PL Shupik National Academy of Postgraduate Education \nLakhno Igor has been graduated from an international training courses on reproductive medicine and family planning held in Debrecen University (Hungary) in 1997. Since 1998 Lakhno Igor has worked as an associate professor of the department of obstetrics and gynecology of VN Karazin National University and an associate professor of the perinatology, obstetrics and gynecology department of Kharkiv Medical Academy of Postgraduate Education. Since June 2019 he’s a professor of the department of obstetrics and gynecology of VN Karazin National University and a professor of the perinatology, obstetrics and gynecology department of Kharkiv Medical Academy of Postgraduate Education . He’s an author of about 200 printed works and there are 17 of them in Scopus or Web of Science databases. Lakhno Igor is a rewiever of Journal of Obstetrics and Gynaecology (Taylor and Francis), Informatics in Medicine Unlocked (Elsevier), The Journal of Obstetrics and Gynecology Research (Wiley), Endocrine, Metabolic & Immune Disorders-Drug Targets (Bentham Open), The Open Biomedical Engineering Journal (Bentham Open), etc. He’s defended a dissertation for DSc degree \\'Pre-eclampsia: prediction, prevention and treatment”. Lakhno Igor has participated as a speaker in several international conferences and congresses (International Conference on Biological Oscillations April 10th-14th 2016, Lancaster, UK, The 9th conference of the European Study Group on Cardiovascular Oscillations). His main scientific interests: obstetrics, women’s health, fetal medicine, cardiovascular medicine.",institutionString:"V.N. Karazin Kharkiv National University",institution:{name:"Kharkiv Medical Academy of Postgraduate Education",country:{name:"Ukraine"}}},{id:"89721",title:"Dr.",name:"Mehmet",middleName:"Cuneyt",surname:"Ozmen",slug:"mehmet-ozmen",fullName:"Mehmet Ozmen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/89721/images/7289_n.jpg",biography:null,institutionString:null,institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"243698",title:"M.D.",name:"Xiaogang",middleName:null,surname:"Wang",slug:"xiaogang-wang",fullName:"Xiaogang Wang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243698/images/system/243698.png",biography:"Dr. Xiaogang Wang, a faculty member of Shanxi Eye Hospital specializing in the treatment of cataract and retinal disease and a tutor for postgraduate students of Shanxi Medical University, worked in the COOL Lab as an international visiting scholar under the supervision of Dr. David Huang and Yali Jia from October 2012 through November 2013. Dr. Wang earned an MD from Shanxi Medical University and a Ph.D. from Shanghai Jiao Tong University. Dr. Wang was awarded two research project grants focused on multimodal optical coherence tomography imaging and deep learning in cataract and retinal disease, from the National Natural Science Foundation of China. He has published around 30 peer-reviewed journal papers and four book chapters and co-edited one book.",institutionString:"Shanxi Eye Hospital",institution:{name:"Shanxi Eye Hospital",country:{name:"China"}}},{id:"242893",title:"Ph.D. Student",name:"Joaquim",middleName:null,surname:"De Moura",slug:"joaquim-de-moura",fullName:"Joaquim De Moura",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/242893/images/7133_n.jpg",biography:"Joaquim de Moura received his degree in Computer Engineering in 2014 from the University of A Coruña (Spain). In 2016, he received his M.Sc degree in Computer Engineering from the same university. He is currently pursuing his Ph.D degree in Computer Science in a collaborative project between ophthalmology centers in Galicia and the University of A Coruña. His research interests include computer vision, machine learning algorithms and analysis and medical imaging processing of various kinds.",institutionString:null,institution:{name:"University of A Coruña",country:{name:"Spain"}}},{id:"267434",title:"Dr.",name:"Rohit",middleName:null,surname:"Raja",slug:"rohit-raja",fullName:"Rohit Raja",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRZkkQAG/Profile_Picture_2022-05-09T12:55:18.jpg",biography:null,institutionString:null,institution:null},{id:"294334",title:"B.Sc.",name:"Marc",middleName:null,surname:"Bruggeman",slug:"marc-bruggeman",fullName:"Marc Bruggeman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/294334/images/8242_n.jpg",biography:"Chemical engineer graduate, with a passion for material science and specific interest in polymers - their near infinite applications intrigue me. \n\nI plan to continue my scientific career in the field of polymeric biomaterials as I am fascinated by intelligent, bioactive and biomimetic materials for use in both consumer and medical applications.",institutionString:null,institution:null},{id:"244950",title:"Dr.",name:"Salvatore",middleName:null,surname:"Di Lauro",slug:"salvatore-di-lauro",fullName:"Salvatore Di Lauro",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0030O00002bSF1HQAW/ProfilePicture%202021-12-20%2014%3A54%3A14.482",biography:"Name:\n\tSALVATORE DI LAURO\nAddress:\n\tHospital Clínico Universitario Valladolid\nAvda Ramón y Cajal 3\n47005, Valladolid\nSpain\nPhone number: \nFax\nE-mail:\n\t+34 983420000 ext 292\n+34 983420084\nsadilauro@live.it\nDate and place of Birth:\nID Number\nMedical Licence \nLanguages\t09-05-1985. Villaricca (Italy)\n\nY1281863H\n474707061\nItalian (native language)\nSpanish (read, written, spoken)\nEnglish (read, written, spoken)\nPortuguese (read, spoken)\nFrench (read)\n\t\t\nCurrent position (title and company)\tDate (Year)\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. Private practise.\t2017-today\n\n2019-today\n\t\n\t\nEducation (High school, university and postgraduate training > 3 months)\tDate (Year)\nDegree in Medicine and Surgery. University of Neaples 'Federico II”\nResident in Opthalmology. Hospital Clinico Universitario Valladolid\nMaster in Vitreo-Retina. IOBA. University of Valladolid\nFellow of the European Board of Ophthalmology. Paris\nMaster in Research in Ophthalmology. University of Valladolid\t2003-2009\n2012-2016\n2016-2017\n2016\n2012-2013\n\t\nEmployments (company and positions)\tDate (Year)\nResident in Ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl.\nFellow in Vitreo-Retina. IOBA. University of Valladolid\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. \n\t2012-2016\n2016-2017\n2017-today\n\n2019-Today\n\n\n\t\nClinical Research Experience (tasks and role)\tDate (Year)\nAssociated investigator\n\n' FIS PI20/00740: DESARROLLO DE UNA CALCULADORA DE RIESGO DE\nAPARICION DE RETINOPATIA DIABETICA BASADA EN TECNICAS DE IMAGEN MULTIMODAL EN PACIENTES DIABETICOS TIPO 1. Grant by: Ministerio de Ciencia e Innovacion \n\n' (BIO/VA23/14) Estudio clínico multicéntrico y prospectivo para validar dos\nbiomarcadores ubicados en los genes p53 y MDM2 en la predicción de los resultados funcionales de la cirugía del desprendimiento de retina regmatógeno. Grant by: Gerencia Regional de Salud de la Junta de Castilla y León.\n' Estudio multicéntrico, aleatorizado, con enmascaramiento doble, en 2 grupos\nparalelos y de 52 semanas de duración para comparar la eficacia, seguridad e inmunogenicidad de SOK583A1 respecto a Eylea® en pacientes con degeneración macular neovascular asociada a la edad' (CSOK583A12301; N.EUDRA: 2019-004838-41; FASE III). Grant by Hexal AG\n\n' Estudio de fase III, aleatorizado, doble ciego, con grupos paralelos, multicéntrico para comparar la eficacia y la seguridad de QL1205 frente a Lucentis® en pacientes con degeneración macular neovascular asociada a la edad. (EUDRACT: 2018-004486-13). Grant by Qilu Pharmaceutical Co\n\n' Estudio NEUTON: Ensayo clinico en fase IV para evaluar la eficacia de aflibercept en pacientes Naive con Edema MacUlar secundario a Oclusion de Vena CenTral de la Retina (OVCR) en regimen de tratamientO iNdividualizado Treat and Extend (TAE)”, (2014-000975-21). Grant by Fundacion Retinaplus\n\n' Evaluación de la seguridad y bioactividad de anillos de tensión capsular en conejo. Proyecto Procusens. Grant by AJL, S.A.\n\n'Estudio epidemiológico, prospectivo, multicéntrico y abierto\\npara valorar la frecuencia de la conjuntivitis adenovírica diagnosticada mediante el test AdenoPlus®\\nTest en pacientes enfermos de conjuntivitis aguda”\\n. National, multicenter study. Grant by: NICOX.\n\nEuropean multicentric trial: 'Evaluation of clinical outcomes following the use of Systane Hydration in patients with dry eye”. Study Phase 4. Grant by: Alcon Labs'\n\nVLPs Injection and Activation in a Rabbit Model of Uveal Melanoma. Grant by Aura Bioscience\n\nUpdating and characterization of a rabbit model of uveal melanoma. Grant by Aura Bioscience\n\nEnsayo clínico en fase IV para evaluar las variantes genéticas de la vía del VEGF como biomarcadores de eficacia del tratamiento con aflibercept en pacientes con degeneración macular asociada a la edad (DMAE) neovascular. Estudio BIOIMAGE. IMO-AFLI-2013-01\n\nEstudio In-Eye:Ensayo clínico en fase IV, abierto, aleatorizado, de 2 brazos,\nmulticçentrico y de 12 meses de duración, para evaluar la eficacia y seguridad de un régimen de PRN flexible individualizado de 'esperar y extender' versus un régimen PRN según criterios de estabilización mediante evaluaciones mensuales de inyecciones intravítreas de ranibizumab 0,5 mg en pacientes naive con neovascularización coriodea secunaria a la degeneración macular relacionada con la edad. CP: CRFB002AES03T\n\nTREND: Estudio Fase IIIb multicéntrico, randomizado, de 12 meses de\nseguimiento con evaluador de la agudeza visual enmascarado, para evaluar la eficacia y la seguridad de ranibizumab 0.5mg en un régimen de tratar y extender comparado con un régimen mensual, en pacientes con degeneración macular neovascular asociada a la edad. CP: CRFB002A2411 Código Eudra CT:\n2013-002626-23\n\n\n\nPublications\t\n\n2021\n\n\n\n\n2015\n\n\n\n\n2021\n\n\n\n\n\n2021\n\n\n\n\n2015\n\n\n\n\n2015\n\n\n2014\n\n\n\n\n2015-16\n\n\n\n2015\n\n\n2014\n\n\n2014\n\n\n\n\n2014\n\n\n\n\n\n\n\n2014\n\nJose Carlos Pastor; Jimena Rojas; Salvador Pastor-Idoate; Salvatore Di Lauro; Lucia Gonzalez-Buendia; Santiago Delgado-Tirado. Proliferative vitreoretinopathy: A new concept of disease pathogenesis and practical\nconsequences. Progress in Retinal and Eye Research. 51, pp. 125 - 155. 03/2016. DOI: 10.1016/j.preteyeres.2015.07.005\n\n\nLabrador-Velandia S; Alonso-Alonso ML; Di Lauro S; García-Gutierrez MT; Srivastava GK; Pastor JC; Fernandez-Bueno I. Mesenchymal stem cells provide paracrine neuroprotective resources that delay degeneration of co-cultured organotypic neuroretinal cultures.Experimental Eye Research. 185, 17/05/2019. DOI: 10.1016/j.exer.2019.05.011\n\nSalvatore Di Lauro; Maria Teresa Garcia Gutierrez; Ivan Fernandez Bueno. Quantification of pigment epithelium-derived factor (PEDF) in an ex vivo coculture of retinal pigment epithelium cells and neuroretina.\nJournal of Allbiosolution. 2019. ISSN 2605-3535\n\nSonia Labrador Velandia; Salvatore Di Lauro; Alonso-Alonso ML; Tabera Bartolomé S; Srivastava GK; Pastor JC; Fernandez-Bueno I. Biocompatibility of intravitreal injection of human mesenchymal stem cells in immunocompetent rabbits. Graefe's archive for clinical and experimental ophthalmology. 256 - 1, pp. 125 - 134. 01/2018. DOI: 10.1007/s00417-017-3842-3\n\n\nSalvatore Di Lauro, David Rodriguez-Crespo, Manuel J Gayoso, Maria T Garcia-Gutierrez, J Carlos Pastor, Girish K Srivastava, Ivan Fernandez-Bueno. A novel coculture model of porcine central neuroretina explants and retinal pigment epithelium cells. Molecular Vision. 2016 - 22, pp. 243 - 253. 01/2016.\n\nSalvatore Di Lauro. Classifications for Proliferative Vitreoretinopathy ({PVR}): An Analysis of Their Use in Publications over the Last 15 Years. Journal of Ophthalmology. 2016, pp. 1 - 6. 01/2016. DOI: 10.1155/2016/7807596\n\nSalvatore Di Lauro; Rosa Maria Coco; Rosa Maria Sanabria; Enrique Rodriguez de la Rua; Jose Carlos Pastor. Loss of Visual Acuity after Successful Surgery for Macula-On Rhegmatogenous Retinal Detachment in a Prospective Multicentre Study. Journal of Ophthalmology. 2015:821864, 2015. DOI: 10.1155/2015/821864\n\nIvan Fernandez-Bueno; Salvatore Di Lauro; Ivan Alvarez; Jose Carlos Lopez; Maria Teresa Garcia-Gutierrez; Itziar Fernandez; Eva Larra; Jose Carlos Pastor. Safety and Biocompatibility of a New High-Density Polyethylene-Based\nSpherical Integrated Porous Orbital Implant: An Experimental Study in Rabbits. Journal of Ophthalmology. 2015:904096, 2015. DOI: 10.1155/2015/904096\n\nPastor JC; Pastor-Idoate S; Rodríguez-Hernandez I; Rojas J; Fernandez I; Gonzalez-Buendia L; Di Lauro S; Gonzalez-Sarmiento R. Genetics of PVR and RD. Ophthalmologica. 232 - Suppl 1, pp. 28 - 29. 2014\n\nRodriguez-Crespo D; Di Lauro S; Singh AK; Garcia-Gutierrez MT; Garrosa M; Pastor JC; Fernandez-Bueno I; Srivastava GK. Triple-layered mixed co-culture model of RPE cells with neuroretina for evaluating the neuroprotective effects of adipose-MSCs. Cell Tissue Res. 358 - 3, pp. 705 - 716. 2014.\nDOI: 10.1007/s00441-014-1987-5\n\nCarlo De Werra; Salvatore Condurro; Salvatore Tramontano; Mario Perone; Ivana Donzelli; Salvatore Di Lauro; Massimo Di Giuseppe; Rosa Di Micco; Annalisa Pascariello; Antonio Pastore; Giorgio Diamantis; Giuseppe Galloro. Hydatid disease of the liver: thirty years of surgical experience.Chirurgia italiana. 59 - 5, pp. 611 - 636.\n(Italia): 2007. ISSN 0009-4773\n\nChapters in books\n\t\n' Salvador Pastor Idoate; Salvatore Di Lauro; Jose Carlos Pastor Jimeno. PVR: Pathogenesis, Histopathology and Classification. Proliferative Vitreoretinopathy with Small Gauge Vitrectomy. Springer, 2018. ISBN 978-3-319-78445-8\nDOI: 10.1007/978-3-319-78446-5_2. \n\n' Salvatore Di Lauro; Maria Isabel Lopez Galvez. Quistes vítreos en una mujer joven. Problemas diagnósticos en patología retinocoroidea. Sociedad Española de Retina-Vitreo. 2018.\n\n' Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor Jimeno. iOCT in PVR management. OCT Applications in Opthalmology. pp. 1 - 8. INTECH, 2018. DOI: 10.5772/intechopen.78774.\n\n' Rosa Coco Martin; Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor. amponadores, manipuladores y tinciones en la cirugía del traumatismo ocular.Trauma Ocular. Ponencia de la SEO 2018..\n\n' LOPEZ GALVEZ; DI LAURO; CRESPO. OCT angiografia y complicaciones retinianas de la diabetes. PONENCIA SEO 2021, CAPITULO 20. (España): 2021.\n\n' Múltiples desprendimientos neurosensoriales bilaterales en paciente joven. Enfermedades Degenerativas De Retina Y Coroides. SERV 04/2016. \n' González-Buendía L; Di Lauro S; Pastor-Idoate S; Pastor Jimeno JC. Vitreorretinopatía proliferante (VRP) e inflamación: LA INFLAMACIÓN in «INMUNOMODULADORES Y ANTIINFLAMATORIOS: MÁS ALLÁ DE LOS CORTICOIDES. RELACION DE PONENCIAS DE LA SOCIEDAD ESPAÑOLA DE OFTALMOLOGIA. 10/2014.",institutionString:null,institution:null},{id:"265335",title:"Mr.",name:"Stefan",middleName:"Radnev",surname:"Stefanov",slug:"stefan-stefanov",fullName:"Stefan Stefanov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/265335/images/7562_n.jpg",biography:null,institutionString:null,institution:null},{id:"318905",title:"Prof.",name:"Elvis",middleName:"Kwason",surname:"Tiburu",slug:"elvis-tiburu",fullName:"Elvis Tiburu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Ghana",country:{name:"Ghana"}}},{id:"336193",title:"Dr.",name:"Abdullah",middleName:null,surname:"Alamoudi",slug:"abdullah-alamoudi",fullName:"Abdullah Alamoudi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"318657",title:"MSc.",name:"Isabell",middleName:null,surname:"Steuding",slug:"isabell-steuding",fullName:"Isabell Steuding",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Harz University of Applied Sciences",country:{name:"Germany"}}},{id:"318656",title:"BSc.",name:"Peter",middleName:null,surname:"Kußmann",slug:"peter-kussmann",fullName:"Peter Kußmann",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Harz University of Applied Sciences",country:{name:"Germany"}}},{id:"338222",title:"Mrs.",name:"María José",middleName:null,surname:"Lucía Mudas",slug:"maria-jose-lucia-mudas",fullName:"María José Lucía Mudas",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Carlos III University of Madrid",country:{name:"Spain"}}},{id:"147824",title:"Mr.",name:"Pablo",middleName:null,surname:"Revuelta Sanz",slug:"pablo-revuelta-sanz",fullName:"Pablo Revuelta Sanz",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Carlos III University of Madrid",country:{name:"Spain"}}}]}},subseries:{item:{id:"12",type:"subseries",title:"Human Physiology",keywords:"Anatomy, Cells, Organs, Systems, Homeostasis, Functions",scope:"Human physiology is the scientific exploration of the various functions (physical, biochemical, and mechanical properties) of humans, their organs, and their constituent cells. The endocrine and nervous systems play important roles in maintaining homeostasis in the human body. Integration, which is the biological basis of physiology, is achieved through communication between the many overlapping functions of the human body's systems, which takes place through electrical and chemical means. Much of the basis of our knowledge of human physiology has been provided by animal experiments. Because of the close relationship between structure and function, studies in human physiology and anatomy seek to understand the mechanisms that help the human body function. 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His interest later turned to the molecular mechanism and attenuating strategy of sarcopenia (age-related muscle atrophy). His opinion is to attenuate sarcopenia by improving autophagic defects using nutrient- and pharmaceutical-based treatments.",institutionString:null,institution:{name:"Tokyo Institute of Technology",institutionURL:null,country:{name:"Japan"}}},editorTwo:null,editorThree:{id:"331519",title:"Dr.",name:"Kotomi",middleName:null,surname:"Sakai",slug:"kotomi-sakai",fullName:"Kotomi Sakai",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000031QtFXQA0/Profile_Picture_1637053227318",biography:"Senior researcher Kotomi Sakai, Ph.D., MPH, works at the Research Organization of Science and Technology in Ritsumeikan University. She is a researcher in the geriatric rehabilitation and public health field. She received Ph.D. from Nihon University and MPH from St.Luke’s International University. 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In recent years, the application of chemistry to biological molecules has gained significant interest in medicinal and pharmacological studies. This topic will be devoted to understanding the interplay between biomolecules and chemical compounds, their structure and function, and their potential applications in related fields. Being a part of the biochemistry discipline, the ideas and concepts that have emerged from Chemical Biology have affected other related areas. 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Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. 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Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. 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