The optimized antennas (all dimensions in mm) [27].
\r\n\t
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His current position is the Head of Biopolymers & Nanobiotechnology Group at the Center of Excellence, National Research Center in Egypt. \nProf. Elnashar’s fields of interest are in the production of Nano to Macro Beads, Biopolymers Grafting, Immobilized Enzymes, Drug Delivery Systems, Nano Magnetic Particles, Diagnostic Kits (Immunology) and Water Purification.",institutionString:"Curtin University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"2",institution:{name:"Curtin University",institutionURL:null,country:{name:"Australia"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"14",title:"Materials Science",slug:"materials-science"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"466998",firstName:"Dragan",lastName:"Miljak",middleName:"Anton",title:"Mr.",imageUrl:"https://mts.intechopen.com/storage/users/466998/images/21564_n.jpg",email:"dragan@intechopen.com",biography:"As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. 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Kawsar Alam",coverURL:"https://cdn.intechopen.com/books/images_new/6805.jpg",editedByType:"Edited by",editors:[{id:"199691",title:"Dr.",name:"Md. Kawsar",surname:"Alam",slug:"md.-kawsar-alam",fullName:"Md. 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Federal Communication Commission (FCC) issued a report in February 2002, allowing the commercial and unlicensed deployment of UWB applications in USA for both indoor and outdoor spectral mask. This wide frequency allocation initiated a lot of researches from both industry and academia [1]. UWB is used for short and medium range of radio communications and positioning applications.
The European regulatory body issue similar restrictions are shown in Figure 1. The key limitations for wireless communication using UWB are mentioned in [2, 3, 4].
European regulatory body spectrum.
UWB impulse radio system has several advantages over other conventional systems [5].
High data rate wireless transmission: UWB systems can support more than 500 Mb/s data transmission rate in the range of 10 m, which enables for new services and applications.
High precision ranging: UWB systems have good time-domain resolution and it could be provided centimeter accuracy for location and tracking applications.
UWB is used for location and tracking applications with cm accuracy.
UWB can operate under LOS and NLOS environments for signal penetrating obstacles.
UWB system is capable of resistance to multipath fading.
The power spectral density is very low so it is secure and can coexist with other services such as WLAN, GPS, cellular system, etc.
The UWB system has low cost due to using CMOS technology.
Due to UWB technology and using nanosecond pulses in many applications such as military and biotechnology applications [6, 7, 8], the need for very broadband circularly polarized antenna has emerged. These UWB CP antennas are the substitution of the narrowband CP microstrip patch antennas [8, 9, 10].
One of the most commonly used devices to control the spectrum of radio frequency signals and necessary in an UWB radio system whether in impulse system or multiband system, in order to reconfigure the UWB signal to satisfy the spectrum regulation is the filter. Ultra-wide band (UWB) band-pass filter that achieves ultra bandwidth from 3.1 to 10.6, low insertion loss, low and flat group delay, out-band performance can be considered a well-designed UWB band-pass filter.
In UWB band-pass filters, one can use many techniques in their design such as composite low-pass and high-pass structure [11], multiple-mode resonator structure [14], and short-circuited stub [12, 13]. Because UBW components occupy a large bandwidth which may be extended from 3.1 up to 10.6 GHz, interference attenuation due to coexisting services should be avoided. This is the motivation of using switchable or tunable narrow band notch within the passband of the UWB filter [15, 16, 17]. This may be achieved by many methods such as using additional notch resonators [18], embedded open stubs [19], asymmetric coupled fed lines [20], out-of-phase transmission cancelation [21], meander-line slots [22], and short-circuited stub resonators in a multilayer periodical structure [23].
To deal with different co-existed communication needs, the reconfigurable notch band implementation is required, but little research is concentrated on a UWB BPF with reconfigurable, switchable, or tunable notch bands as in [24, 25, 26].
An HFSS, FEM-based, 3D full wave electromagnetic solver simulator by ANSYS as well as CST were used for the design of all designed antennas. Also, ADS was used to design the filters and filtennas in addition to the above electromagnetic simulators in this chapter.
This chapter describes one example for printed millimeter wave antenna implementations, illustrating specific and interesting particular solutions for their design and two shapes of single UWB antenna in radio frequency range. In addition, two examples of UWB filters and one example of UWB filtennas are introduced.
Classical antenna as reflector, lens, and horn type antennas have been used in millimeter-wave devices. But for low-cost, these antennas are commercial expensive devices, bulky, heavy and require complex feeding in an array system. In addition, they are very difficult to integrate with solid-state devices [6, 7, 8, 9]. However, the microstrip antennas (MPAs) are narrow bandwidth and are large size about half-wavelength structures.
Three different types of broad multi-band linearly and circularly polarized slot antennas (rectangular-, circular-, and triangular-shaped slots) for millimeter wave wireless communication applications [27] are shown in Figures 2 and 3, respectively. Proposed antenna consists of a slot radiator on the top metal layer and coupled to a rectangular dielectric resonator above the slot. The conventional microstrip-line-feed is used for different shapes of slot antennas. Final designed antennas were fabricated, and their characteristics were measured as reflection coefficient. The bandwidth of |S11| < −10 dB was extended from 19.5 up to 75 GHz. This band covers wireless MM-wave applications and wireless networks, and the WLAN, WPAN, and W-bands and most of 5th Generation mobile [28, 29, 30, 31, 32]. The average radiation efficiency and gain over the entire operating band are about 60% and 6 dBi, respectively [27]. Printed different shapes of slot antenna show small dimensions (
Different shapes of slot antenna for LP (a) rectangular, (b) circular, (c) triangular, and (d) side view [
Shapes of slot antenna for circular polarization (a) rectangular, (b) circular, and (c) triangular [
7 | 10 | 4 | 2.9 | 11.6 | 0.25 | 4.5 | 0.6 | 0.7 | 4.5 |
8.6 | 8.5 | 0.56 | 0.6 | 4 | 0.7 | 0.7 | 0.6 | 0.7 | 4.5 |
The optimized antennas (all dimensions in mm) [27].
The first shape of antenna design is either square with side length = 3.5 mm or rectangular slot with dimensions
Antenna |S11| response with different slot shapes (a) rectangular, (b) circular, and (c) triangular [
Single-feed MPAs for CP are usually achieved by using traditional simple changes in the shape of the patch such as truncating corners, using nearly square or nearly circular patches, cutting a diagonal slot in the square or circular patches, protruding or inserting a pair of symmetric perturbation elements at the boundary of a circular patch [33, 34, 35]. However, this type produced narrow axial ratio (AR) bandwidth. The dual-fed and sequential array structure produced wider AR bandwidth, but this requires more complicated design and may occupy larger space. Slot antennas are expected to overcome the limited bandwidth problem as well as similar changes in the slot shape could be used to achieve CP.
Rectangular notches etched in the rectangular slot are used as a way to improve the 3 dB AR bandwidth as shown in Figure 5(a). The notch width C1 = C2 = 0.7 mm gives the best wideband AR. The comparison of AR between measured and simulated is also shown in Figure 5(a).
Axial ratio of the antennas with different slot shapes (a) rectangular, (b) circular, and (c) triangular [
In the proposed design, a square stub with dimension side K was added to the circular shaped slot to achieve the CP performance. The stub is added at a radial distance t from square stub. The locations of this stub set the AR bandwidth without degrading the antenna performance as shown in Figure 5(b). This figure shows that the stub with notch at a distance t = 3 mm gives the best performance AR bandwidth. However, AR bandwidth discontinuities appear from 40 to 55 GHz. The comparison results of AR values simulated and measured at t = 3 mm is shown in Figure 5(b). Finally, for the triangular slot shape, a truncated corner was used. To improve the AR bandwidth, an L-shaped strip was added at the other triangular corner with width 0.1 mm as shown in Figure 3. The bandwidth for simulated and measured AR values for the triangular CP antenna is shown in Figure 5(c). From previous shapes, it appears that rectangular shaped slot with notches gives wide axial ratio bandwidth without degrading the antenna bandwidth.
The proposed antenna designs were fabricated by using milling machine technology with 0.1 mm accuracy on Rogers 6035HTC substrate with a 0.25 dielectric thickness and 0.017-mm copper thickness. A 1.85-mm end launcher connector is used to measure the proposed antennas. The simulation reflection coefficient was verified by comparison with the experimental results of the antennas by using 37397C Anritsu vector network analyzer. Photos of the fabricated antennas are shown in Figures 6 and 7. The comparison between measured and simulated |S11| for linearly and circularly proposed antennas are shown in Figure 8(i) and (ii), respectively. The measurement and simulation result data are in a good agreement. Measured results ended at 65 GHz as it is the end-point of the network analyzer. The rectangular slot shape gives the best antenna performance for linearly and circularly polarized slots. These designs also have low profile, wide impedance bandwidth |S11| < −10 dB, and wide 3 dB axial ratio.
Photo of fabricated linear polarized slot antenna, (a) rectangular, (b) circular, and (c) triangular shaped [
Photo of fabricated circular polarized slot antenna, (a) rectangular, (b) circular, and (c) triangular shaped [
Measured and simulated |S11| of (i) linear polarized (a) rectangular, (b) circular, and (c) triangular slot shaped and (ii) circular polarized (a) rectangular, (b) circular, and (c) triangular slot shaped [
Planar microwave circuitry has generated attractive radiating structures with high gain, low weight, reliability, ease of manufacturing and integration such as the Vivaldi antennas [36, 37], and the tapered slot antenna [38] for UWB antennas. The printed planar log-periodic dipole (LPDA) is the most suitable solution microwave frequencies [39]. LPDAs have a lot of advantages, such as directive radiation pattern, linear polarization and low cross polarization ratio over a wide frequency range [5]. At the beginning, coaxial cable was used for feeding the printed LPDAs at the radio and the TV frequency bands; however, it was found that the performance became worse when frequency increases. Due to huge increase in data traffic, there is a requirement for wireless networks which support both data and voice transfer simultaneously for short-range wireless communication systems [1, 2].
This section presents a LPDA for UWB applications [39]. The antenna consists of cascading four U-shaped elements of different line lengths with balun circuit to improve the antenna impedance matching. The proposed antenna area dimensions are 50 × 50 mm2 built on FR4 substrate thickness 0.8 mm. Simulator HFSS is used for modeling the designed antenna. The pulse distortion is verified by measuring the proposed antenna performance with virtually steady group delay. The simulation and measurement results show that the designed antenna exhibits good impedance matching, stable radiation patterns throughout the whole operating frequency bands, acceptable gain and stable group delay over the entire operating band.
LPDA is UWB with the multiple resonance property; its bandwidth can be enhanced by increasing the number of the dipole elements [40, 41, 42]. Balanced structure, CPW fed antennas are very good candidates since the feed lines and the slots are on the same side of the substrate. There are many researches done to design LPDA but most of the published papers are not compact and their length is near from wavelength. The compact antenna dimensions, as shown in Figure 9, are 50 × 50 × 0.8 mm3. The proposed USLPDA antenna introduces USUWB with the multiple resonant property and compact size compared to earlier designs where UWB was realized using a rectangular slot [43], U-shaped dipole elements or stubs [38]. The bandwidth of this antenna at −10 dB reflection coefficient extends from 1.85 to 11 GHz which is wide enough to cover the FCC approved UWB in addition to wireless communications. The antenna exhibits good performance and can operate at wireless applications.
Layout of the proposed log periodic dipole antenna (semi-LPDA) [
The designed geometry antenna is shown in Figure 9; the antenna is composed of four different lengths with U-shaped stubs. The lengths and spacing of the elements of LPDA increase logarithmically from one end to the other. The design of the LPDA is used where a wide range of frequencies is needed while still having moderate gain and directionality. The simulator HFSS is used to validate and optimize by simulating the designed antenna. The designed antenna is built on a commercial FR4 substrate with dielectric constant εr = 4.6, and loss tangent tan δ = 0.02. The antenna is fed by a 50 Ω transmission line, which can be easily integrated with other microwave circuits printed on the same substrate. For designing procedure, the number of trial steps is needed, the scale-factor τ, spacing factor δ, and the number of the dipole elements N should be determined. Second, the length of the longest arm, which responses to the lowest resonance frequency f1, should be computed by following Eqs. (1)–(6) [39].
where λ1eff, Bo, N, and int i are the longest effective operating wavelength, the operating frequency, number of elements, and i is an integer that varies from 2 to 5, respectively. To improve the impedance, matching the balun circuit with suitable dimensions is used as shown in Figure 9. Table 2 introduces the dimensions of the proposed antenna [39].
50 | 13.5 | 50 | 24 | 15.3 | 11.7 | 8.5 | 0.9 | 0.6 | 6 |
7.6 | 2.1 | 45 | 2.8 | 3.6 | 3 | 6 | 8.5 | 4.5 | 1000 |
Dimensions of the proposed antenna (dimensions in mm) [39].
The designed antenna is fabricated by using photolithographic technique, as shown in Figure 10, and parameter performance is measured. The simulated and measured input reflection coefficient of the antennas is in good agreement, as shown in Figure 10(b). The designed dipole impedance bandwidth at −10 dB of antenna extended from 1.85 to 11 GHz to cover most of the wireless applications and FCC UWB regulation. The antenna gain data are compared between measured and simulated results as shown in Figure 11. The designed LPDA antenna achieves simulated average gain 5.5 dBi, and the peak realized gain around 6.5 dBi at 2.7 GHz as shown in Figure 11(a). The measured results show very good agreement with simulated results and about ±3 dBi difference on average over the operating band. Wheeler cap method [44] can be used to calculate the antenna radiation efficiency. The average radiation efficiency is around 70% over the operating band as shown in Figure 11(b).
(a) GD simulated structures and (b) comparison between measured and simulated GD of LPDA [
(a) Fabricated LPDA antenna and (b) |S11|comparison between simulated and measured results [
Then the radiation efficiency measured result is done by using horn antenna to complete the designed antenna radiation efficiency measurement as shown in Figure 11(b). In the designed antenna, the radiator and the ground plane are contributing to radiation. For UWB applications, omnidirectional radiation pattern is an important requirement. At lower frequency band of operation, the pattern resembles a conventional dipole antenna, but at higher end of the UWB spectrum, some ripples are observed which are attributed to higher order modes. There are discrepancies observed at higher frequency band spectrum, which arises due to measurement setup.
For UWB applications, group delay is an important factor in communication systems, for example, medical applications systems, security systems, and satellite communication systems, which are used for transmitting. To avoid occurring of distortion, it is recommended that the spectrum is treated in the same manner, over the proposed bandwidth of frequencies. When GD ripples are large, they may cause unsatisfactory distortion in the signal of a transmitting radio system. So, in radio system designs, there are specifications for how much a GD may be accepted. In nonlinear systems, nonlinear distortion happens since the magnitude of frequency response is not constant, and the phase response is nonlinear. The phase distortion could be used to measure GD, the phase characteristics must have a linear slope so that the ratio is constant for all frequencies and this represents a constant GD [44]. To measure the GD between two antennas with spacing d = 1 m, the usual practice is to derive Q/ω for |S21| phase. However, it is desirable that the same antenna is used for transition and receiving. High GD variations occur due to the steep phase shift over frequency, which may cause unsatisfactory distortions in the signal. Figure 12 illustrates the simulated GD, and it can be noticed that the average group delay is about 1.5 × 10−9 second.
Comparison between simulated and measured results (a) gain and (b) radiation efficiency of LPDA [
This section presents designed steps to model an UWB monopole antenna. The designed antenna is composed of three different lengths of semi-circular shapes connected with circular disk and half circular modified ground plane. The designed antenna has an area equal 50 × 50 mm2 on a low cost FR4 substrate [45]. The antenna demonstrates impedance bandwidth of −10 dB extended from 1.5 to 11 GHz with discontinuous bandwidth at different interior operating bands. Two pairs of SRR as metamaterial structure cells are inserted closely located from feeding transmission line of the antenna to achieve good impedance matching over the entire band of operation and improve the antenna performance. The fundamental parameters of the antenna including reflection coefficient, gain, radiation pattern, and group delay are obtained, and they meet the acceptable UWB antenna standard. Simulator HFSS ver. 14 is used as full wave electromagnetic solver then the prototypes are fabricated and measured. Results show that the antenna is very suitable for the applications in UWB as well as wireless communication systems.
For use in UWB systems, printed monopole patch antenna (PMPA) is an extremely attractive candidate because of its wide impedance bandwidth, omnidirectional azimuthal radiation pattern, low profile, and ease of integration with active devices and fabrication [46]. The design equation for lower band edge frequency has been reported in the literature. Moreover, these antennas are analyzed by using the frequency domain characteristics like return loss, gain, radiation pattern, surface current distribution, and group delay. Different narrowband services like WLAN, WiMax, GSM, UMTS, Wi-Fi, WMTS, ISM, UNII, DECT, European Hiper LAN I, II, and UWB (3.1–10.6 GHz) applications [1] could be obtained by using single UWB antenna.
A SRR is one of the electrically smallest resonant elements. It has many applications ranging from compact filters to advanced metamaterials. SRR has also a significant importance in electrically small antennas [46]. Metamaterials are good candidate for enhancement of the performances of different antennas. There are varieties of SRR structures that have been reported in the literature like square, circular, triangular, omega, and labyrinth resonator [47].
The designed antenna structure is composed of three connected semicircular arc monopoles with circular patch fed by microstrip transmission line and modified half circular shaped ground plane as shown in Figure 13. The initial design is validated and optimized by simulating the proposed antenna. The proposed antenna is designed on FR4 substrate with height 1.6 mm, dielectric constant εr = 4.6, and loss tangent tan δ = 0.02. The antenna is fed by a 50-Ω transmission line (TL).
Evolution of the design steps of the proposed printed monopole. (a) First step, (b) second step, (c) third step, (d) fourth step, (e) fifth step, and (f) sixth step [
The main design parameter for UWB antenna is the lower frequency edge (fL) rather than the resonance frequency (fr) as in Eq. (7). The lower band edge frequency of the designed antenna is calculated approximately by equating their surface area with that of an equivalent cylindrical monopole antenna of the same height as given by [45]. If R1 is the height of the planar monopole antenna in cm, which is taken the same as that of an equivalent cylindrical monopole, and r in cm is the effective radius of the equivalent cylindrical monopole antenna, which is determined by equating area of the planar and cylindrical monopole antennas, then the lower band edge frequency is given as [45]:
where
The design started with first semi arc 1800 with radius 25 mm and with 5 mm width modified ground plane Lg = 19 mm as shown in Figure 13(a), and related |S11| is shown in Figure 14. To improve the bandwidth, second semi sector with radius 17 mm and width 3.5 mm as shown in Figure 13(b) with the same previous dimensions is added to add second resonant as shown in Figure 14. Third sector with radius 7.5 mm and width 2.5 mm is added, and keeping previous dimensions the same as shown in Figure 13(c), a third resonance is achieved as shown in Figure 14. Another extension of the bandwidth is done by adding circular disk with radius 4 mm as shown in Figure 13(d), and related reflection coefficient is shown in Figure 14. Modified ground plane is used to improve the bandwidth with ellipse with major radius 25 mm and minor radius 15 mm, as shown in Figure 13(e), is suggested, and the related reflection is shown in Figure 14. The evolution of designing the proposed configuration is demonstrated in Figure 13(f), and their corresponding optimized dimensions are tabulated in Table 3. The antenna gain and radiation efficiency are also studied as shown in Figure 15. The proposed antenna with SRR achieves an average gain of 7.5 dBi, and the peak realized gain around 22.5 dBi at 7.5 GHz as shown in Figure 15(a). The designed antenna gain without SRR achieves an average gain around 5.5 dBi, while peak gain realized is 15 dBi at 8.5 and 10 GHz. The gain of the designed antenna is also measured, and there is good agreement between results especially at high frequency. The antenna radiation efficiency was simulated for both monopole antennas with and without SRR by using wheeler cap method [44]. The average radiation efficiency is around 70% over the operating bands for PMPA with SRR and around 65% without SRR as shown in Figure 15(b).
50 | 50 | 5 | 3.5 | 2.5 | 25 | 17 |
7.5 | 4 | 5 | 2.4 | 3 | 20 | 20 |
Dimensions of the proposed antenna (all dimensions in mm) [45].
Design procedures of the proposed antenna [
(a) Antenna gain versus frequency and (b) simulated radiation efficiency with and without SRR [
The prototype of the proposed antenna is shown in Figure 16. The performance parameters of the fabricated designed antennas are measured. The comparison results of simulated and measured input |S11| of the antennas are found to be in very good agreement, as shown in Figure 17. The −10 dB bandwidth of the designed monopole antenna with SRR extended from 1.5 to 11 GHz to cover most wireless application and FCC UWB regulation. It is fabricated by using photolithographic technique, and the measurements were carried out by using a Rohde & Schwarz ZVA67 vector network analyzer from 50 MHz to 67 GHz.
Fabricated antenna (a) upper layer without SRR (b) upper layer with SRR, and (c) bottom layer [
Simulated and measured results of (a) monopole without SRR and (b) monopole with SRR [
A filter is a two-port network that is used to control frequency response in a system. Filters can be classified into three main groups of active (requiring external power source), passive (no need for external power), and hybrid filters. Microwave systems are often involved with power conservation and noise control, and therefore, active filters are generally considered as last alternative. Passive filters are, however, further divided into lumped and distributed. The former consists of lumped components (including capacitors, inductors, resistors, and magnetic and electromechanical components), and the latter comprises a periodic conducting structure with various dielectric media. Inductors and capacitors form LC filters whereas resistors and capacitors form RC filters. Although resistors introduce loss to the circuit, they are generally used for broad banding (matching) purposes.
A compact UWB BPF with reconfigurable notch bands based on CRLH transmission line unit cell has been designed, simulated, and fabricated [48]. Two packages of software are used, namely, CST MWS and 3D EM commercial software HFSS version 13.0. The simulated and measured results are comparable. This filter has the advantage of very small size, and it also has four notched frequencies in its passband. The notched bands suppress the narrow-band services such as WLAN and WiMAX. One can control the center frequency of the notched band by varying the length L6 of the stub. The total area of the filter is 16.4 × 5 mm2. This small area makes it suitable for modern applications which need miniaturization.
The proposed filter is designed based on the filter described in Ref. [49] but with a new contribution which is notched controllable tunable four sharp rejection bands by adjusting the length of the coupling stub using diode switching matrix tools (instead of using PIN diodes).
Figure 18 shows the proposed microstrip UWB-BPF with tuned notched passband based on CRLH transmission-line unit cell. The optimized dimensions of the proposed filter are as shown in Table 4.
The proposed filter [
9.3 | 3.4 | 4 | 5.2 | 7.2 | 5.3 | 3.3 | 0.3 | 0.2 |
0.3 | 0.9 | 0.9 | 0.2 | 0.3 | 0.4 | 0.2 | 0.2 | 0.5 |
Optimized dimensions of the proposed filter (all dimensions are in mm) [48].
The dimension of the multi-mode section as shown in Figure 18 is 4.4 × 1.5 mm, the length of the shunted inductive line is 3.1 mm, and the overall dimension of the proposed filter is 16.4 × 5.0 mm. Based on the above description, the design procedure can be as follows:
The notched band depends on the coupling stub (L6) in the output section.
The notch frequency of the filter can be changed by adjusting the length of the coupling stub L6. As L6 increases, the center notch frequency decreases as shown in Table 5. The length L6 is controlled by using switching matrix equipment (mini circuit) where the character D refers to the diode.
Diode states | L6 (mm) | fnotch (GHz) |
---|---|---|
D1, D2, D3 (off) | 2 | 6.18 |
D1(on), D2, D3 (off) | 3.1 | 5.9 |
D1, D2(on), D3(off) | 4.2 | 5.7 |
D1, D2, D3 (on) | 5.3 | 5.5 |
(fnotch) against (L6) variation [48].
The filter was fabricated using a photolithographic technique on Rogers RT/Duroid 5880 with εr = 2.2, h = 0.787 mm, and tan δ = 0.0009. The photograph of the fabricated filter is shown in Figure 19. The measured and simulated S11 and S21 for different stub lengths are shown in Figure 20(a)–(d). The UWB bandwidth extends between 3.1 and 10.6 GHz. There are four notched frequencies for the different stub lengths (L6 = 2.2, 3.1, 4.2 and 5.3 mm). The overall dimension of the filter is 16.4 × 5 mm, which is considered very compact compared to other published designs with the same characteristics. Figure 20(a) shows the measured and simulated S11 and S21 with L6 = 2 mm and fnotch = 6.18 GHz. Figure 20(b) shows the measured and simulated S11 and S21 with L6 = 3.1 mm and fnotch = 5.9 GHz. Figure 20(c) shows the measured and simulated S11 and S21 with L6 = 4.2 mm and fnotch = 5.7 GHz. Figure 20(d) shows the measured and simulated S11 and S21 with L6 = 5.3 mm and fnotch = 5.5 GHz. Good agreement was found between the measured data and simulated results.
A photo for the fabricated filter [
The simulated and measured S11 and S21 for different L6 lengths, (a) L6 = 2.0 mm, (b) L6 = 3.1 mm, (c) L6 = 4.2 mm, and (d) L6 = 5.3 mm [
Ref. [50] proposed a suitable UWB to dual-band band-pass filter with defected ground structure DGS. This filter consists of four parts, namely, meandered inter digital coupled line sections, stepped impedance open stubs, coupled lines, and rectangular DGS. The filter is miniaturized and has a total area of 12.5 × 10 mm, Figure 21. This filter is fabricated on Duroid Teflon substrate with a dielectric constant of 2.2 and a dielectric height of 0.7874 mm. The UWB mode extends from 3.6 up to 10.6 GHz with attenuation greater than 20 dB up to 18 GHz (upper stopband). The dual passbands extended from 3.8 up to 18 GHz (upper stopband). The dual passbands extend from 3.8 up to 5 GHz and from 9.5 up to 10.8 GHz. The proposed filter suppresses WiMAX and X (military) band of satellite that extends from 7 up to 8 GHz. The filter is designed, fabricated, and measured. The mode of the filter is changed by using suitable matrix equipment [50].
The structure of the proposed filter [
DGS at input and output ports of the proposed filter produces two resonances at 7.5 and 9.6 GHz and improve the performance of proposed filter while an overall size reduction of 20% is obtained. The meander lines and stepped impedance open stub are also used to reduce the overall size. By adjusting the connection between the coupled lines in the center of the design, the center frequency and 3 dB frequency band can be easily adjusted. The proposed filter achieves UWB performance with good selectivity and low insertion loss in the passband from 3.6 to 10.5 GHz and good stopband from 10.6 to 18 GHz. Moreover, it achieves dual bands with good stopband from 5 to 9.5 GHz and from 10.8 to 18 GHz by using open circuit stub to suppress unwanted interference signals in the band of WLAN, WIMAX, and X (Military) band of satellite. All dimensions of the proposed filter are as follows: L1 = 3.75 mm, L2 = 1.95 mm, L3 = 1.8 mm, L4 = 7.5 mm, L5 = 2.1 mm, L6 = 1 mm, L7 = 5.65 mm, W1 = 0.2 mm, W2 = 0.5 mm, W3 = 0.15 mm, g1 = 0.2 mm, g2 = 0.2 mm, and g3 = 0.3 mm. The simulated S11 and S21 are shown in Figure 24.
Figure 22 shows the equivalent lumped circuit model of the proposed UWB BPF that is shown in Figure 21. The equivalent lumped circuit model results are obtained using circuit model tool of the Advanced Design System (ADS) 2017. The lumped element values are manually optimized by changing each element value, so that it can have good agreement with the simulated results obtained from the full wave simulator.
Equivalent lumped circuit model of the proposed UWB BPF shown in
The whole equivalent circuit of the proposed filter can be divided into the following subsections: DGS part at input and output ports, interdigital coupled lines and stepped impedance open stub. As shown in the lumped element model (Figure 22), Rd1, Cd1, Ld1, Rd2, Cd2, and Ld2 represent the equivalent resistance, inductance, and capacitance of the defected ground structure (DGS) [51]. L5, C5, L6, and C6 represent the equivalent inductance and capacitance of the stepped impedance resonator (SIR). Interdigital coupled arm is represented by the series capacitance with parasitic inductance and resistance, and shunt capacitances [52] as shown in Figure 22. The S-parameters versus frequency response of EM simulation and circuit model are compared. There is a very good agreement between the simulated and equivalent lumped circuit model results.
Photolithographic technique was used to fabricate this filter on Teflon substrate (Duroid RT 5880) with physical properties of εr =2.2 and tan∂ = 0.0009, while the dielectric thickness is 0.7874 mm. Figure 23 shows a photograph for the fabricated filter for both sides (the front and back sides). The soldered wires shown in Figure 23 are used to connect the filter with diode switch matrix tool. The filters are measured using the vector network analyzer (N9928A FieldFox Handheld Microwave Vector Network Analyzer, 26.5 GHz) [50].
A photo for the fabricated filter [
Figure 24(a) shows the measured and simulated results of the proposed filter at ON state with frequency range from 1 to 20 GHz. It should be noted that the frequency range is extended up to 20 GHz in order to show that the out of band rejection is good, and the measured 3 dB passband of the proposed filter is between 3.6 and 10.6 GHz. Figure 24(b) shows the measured and simulated results of the proposed filter at OFF state, and the dual bands with 3 dB passbands extend from 3.8 to 5 GHz and from 9 to 10.8 GHz [50].
The simulated and measured S11 and S21 without O.C stub. (a) D1 and D2 ON state (with frequency range from 1 to 20 GHz) and (b) D1 and D2 OFF state [
Photos for the fabricated filter with open stub are shown in Figure 25. Figure 26(a) shows the measured and simulated results of the proposed filter with open stub at D1, D2 ON state, and D3 OFF with frequency range from 1 to 20 GHz. It should be noted that the out of band rejection is good, and the measured 3 dB passband of the proposed filter is between 3.6 and 10.6 GHz. Figure 24(b) shows the measured and simulated results of the proposed filter with open stub at D1, D2 OFF state and D3 ON, and the dual bands with 3 dB passbands extend from 3.8 to 5 GHz and from 9.5 to 10.8 GHz [50].
A photo for the fabricated filter of
The simulated and measured S11 and S21 with O.C stub. (a) D1, D2 ON, and D3 OFF, (b) D1, D2 OFF and D3 ON [
In general, the filtenna consists of a filter and antenna that are combined in one structure. The proposed filtenna operates at three bands of frequency (2.4, 5.5, and 28 GHz) to cover the 4G/5G communication system. It consists of three parts, namely, Franklin strip monopole antenna to cover 4G, WLAN, and WiMAX and a rectangular patch antenna to cover 5G band. The third part consists of a modified CMRC low-pass filter that exists between the two antenna parts to isolate the Franklin antenna from the rectangular patch antenna at 5G band. It also allows feeding the Franklin antenna at low frequency bands. The total size of the filtenna is 45 × 40 × 0.508 mm3 and fabricated on Teflon dielectric substrate (Roger 5880). The proposed filtenna has wide impedance bandwidth (15.8, 23.5, and 11.3%) and high gain (1.95, 3.76, 7.35 dBi) [53]. The proposed multiband filtenna is shown in Figure 27.
The proposed multiband filtenna (a) front view and (b) back view [
A modified compact microstrip resonance cell (CMRC) low-pass filter (LPF) using novel fractal patches was proposed in [54], see Figure 28. The fractal patches produce additional transmission zeros to the stop-band, while the open-ended stubs cause an extension in the stopband achieving a compact ultrawide and deep stopband filter with good selectivity and low insertion loss in the passband. The results show −10 dB bandwidth from 3.3 to 67 GHz with 181.5% relative stopband bandwidth. The 3-dB cutoff frequency is 2.85 GHz and less than 1.5 dB insertion loss in the passband and 0.55 GHz transaction from −3 to −20 dB and − 20 dB suppression from 3.5 to 67 GHz, so that the filter can be expected to suppress the unwanted harmonics and prevent inter-modulation with the new systems with high frequency operating bands. The filter has been designed on a Rogers 5880 substrate with a relative dielectric constant of 2.2, substrate thickness of 0.508 mm, and 0.0009 loss tangent. Figure 28 shows the proposed filter design, and it consists of two traditional triangle taper resonance cells in one side of the transverse connecting narrow width transmission line which has almost the same performance of the complete CMRC structure, while two different sizes circular fractal patches are present on the other half. Each fractal consists of main circular patch and additional small circular patches at edges. The two fractals act as a dual behavior resonator to have additional transmission zeros in the stopband. Each fractal is resonating at certain frequency in addition with enhancing the low suppression bands of the entire stop-band. Also, four open ended stubs are used to extend the stopband by adding new transmission zeros without increasing the circuit size. The main dimensions are given in Table 6, all dimensions in millimeter.
The design of proposed low-pass filter [
Parameter | Cl | L | W | Cd1 | Cd2 | a11 | a12 | a13 | a21 |
---|---|---|---|---|---|---|---|---|---|
Value (mm) | 17.6 | 2.4 | 0.15 | 7.6 | 2.1 | 1.35 | 0.2 | 0.05 | 2.9 |
Parameter | a22 | a23 | X1 | X2 | Y1 | Y2 | T1 | T2 | W50 |
Value (mm) | 0.15 | 0.05 | 2.4 | 1.8 | 0.8 | 0.8 | 3.2 | 3.8 | 1.6 |
Circuit dimensional parameters [53].
Part C of the multiband rectenna system is a Franklin strip monopole dual-band antenna to be used to cover Bluetooth at 2.4 GHz, 4G, LTE bands at 2.3, 2.5 and 2.6 GHz, WiMAX at 2.5 and 5.5GHz, WLAN at 2.4, 5.2 GHz [53]. The geometry of the antenna is shown in Figure 29. The antenna has a rectangular stub on a curved partial ground. The length of the bending strip is about one-half of the guide wavelength at its first resonance frequency. The meander radius and the length of the Franklin strip are mainly determining the two resonance frequencies of the antenna, while the rectangular stub with a length of a quarter wavelength and curved ground have been used to increase the bandwidth of the upper band (5.5 GHz). The L-C equivalent circuit of the Franklin monopole antenna is shown in Figure 30. The dimensions of the antenna are shown in Table 7, while the equivalent circuit parameters are shown in Table 8.
The design of the proposed Franklin strip monopole antenna (a) front and (b) back [
The equivalent LC circuit of the proposed 4G Franklin monopole antenna,
35 | 45 | 18.5 | 14.9 | 5.1 | 9.9 |
1 | 1.1 | 1.6 | 1.5 | 13.4 | 14.9 |
Dimensions of the proposed Franklin antenna (all dimensions in mm) [53].
CTL | LTL | Cp | Lp | Rp | CS | LS | Ck | Ccs |
---|---|---|---|---|---|---|---|---|
2 | 1.7 | 2606 | 0.0007 | 0.05 | 0.1 | 0.05 | 18.4 | 42.4 |
Franklin monopole antenna equivalent circuit parameters [53].
The first part of the rectenna (part A) consists of a rectangular patch antenna with inset feed for matching and four CSRRs (complementary split ring resonator) in the other side (ground plane). This antenna covers the 5G range of frequency (28 GHz). This shape is chosen due to its simplicity and can be placed in the Franklin feeding line. Figure 31 shows the geometry of the rectangular patch with inset feeding. The final dimensions of the antenna after using optimization techniques of the CST simulator are introduced in Table 9. The L-C equivalent circuit of this antenna with CSRRs is shown in Figure 32. The rectangular patch is represented as two radiating slots each one represented by a parallel R L C circuit, while each one of the four CSRRs represented by parallel LC and the electric coupling between the CSRRs on the ground and radiating patch on the top side is represented by capacitor Ck and the magnetic coupling represented by the mutual inductance offered by the ADS software. All lumped element values are listed in Table 10 [53].
The design of 5G rectangular patch antenna. (a) Front view, (b) back view, and (c) the dimensions of the CSRR [
(a) The equivalent LC circuit of the proposed 5G rectangular patch antenna [
11 | 7.5 | 6 | 1.6 | 1 | 2.95 | 3.45 |
1.15 | 1.55 | 1.85 | 1.55 | 1.25 | 0.8 | 0.3 |
5G antenna dimensional parameters (all dimensions in mm).
CTL | LTL | Cp1 | Lp1 | Rp1 | Cp2 | Lp2 | Rp2 | Cc | Lc |
---|---|---|---|---|---|---|---|---|---|
17.5 | 0.16 | 1.06 | 0.26 | 93.6 | 10−12 | 0.02 | 54.9 | 0.79 | 1.2 |
5G antenna equivalent circuit parameters.
The equivalent circuit model simulation results of the filtenna system shown in Figure 27 is determined by merging the three parts component’s equivalent circuit, namely, 5G rectangular patch antenna, modified CMRC low-pass filter, and 4G Franklin monopole antenna extract using ADS software [53]. The filtenna was fabricated using the photolithographic technique.
Figure 32 shows a photo of the fabricated rectenna. The simulated and measured reflection coefficient is shown in Figure 33. The measured results show that the filtenna has −10 dB impedance of the first band from 2.16 to 2.53GHz, the second band is from 4.58 to 5.8GHz, and the third band is from 26.8 GHz to 30 GHz. The simulated and measured gains are shown in Figure 34. The first and second bands have peak measured gain level of 1.95 and 3.76 dBi, respectively. The third band achieves 7.35 dBi peak simulated gain level [53].
Photograph of fabricated antenna. (a) Front view, and (b) back view and (c) the measured and simulated reflection coefficient [
Simulated and measured gain at: (a) first band, (b) second band, and (c) simulated gain using CST and HFSS simulators for the third band [
Type 2 diabetes mellitus (T2DM) is among the most prevalent chronic disease [1], affecting approximately 463 million people in 2019, and more than 690 million are expected to be diagnosed by 2045 [2]. People diagnosed with T2DM have a 2–4-fold higher risk of developing cardiovascular disease (CVD) [3]. Despite significant advantages in the prevention strategies that lessen related risk factors, CVD remains the leading cause of morbidity and mortality in patients with T2DM [4].
T2DM and CVD both have multi-factorial etiology, and disorders of lipid metabolism is one of the coexistence features sharing by them. For the development of CVD, the cumulation of ApoB-containing lipoproteins in the arterial wall would lead to lipid deposition and an atheroma initiation, resulting in the progression of atherosclerotic plaques, and eventually atherosclerotic vascular disease [5]. Therefore, lipid-lowering drugs, such as statins, have been recommended as front-line therapy for primary prevention of atherosclerotic CVD [6], and the state-of-the-art therapy in dyslipidemia in diabetic patients [3, 7, 8]. For the potential mechanism between lipid metabolism and diabetes, one meta-analysis reported that lipid parameters, such as triglyceride (TG), and low-density lipoprotein (LDL), can reflect the risk of T2DM [9]. Other lipid subfractions, such as high-density lipoprotein cholesterol (HDL) and lipid-free ApoA-I, could also benefit glycemic control by increasing glucose uptake in skeletal muscle, improving beta-cell function, and decreasing insulin resistance through inhibiting the proinflammatory signal transduction pathways [10].
Considering the rather complex components of lipid and different directions for the associations between different lipid components and diabetes [11], more efforts are needed to elucidate the relationships between lipid profile and diabetes.
There are six major lipoproteins exist in blood: chylomicrons, very-low-density lipoprotein (VLDL), intermediate-density lipoprotein (IDL), low-density lipoprotein (LDL); lipoprotein(a) (Lp(a)), and high-density lipoprotein (HDL) [12]. Dyslipidemia represents a cluster of lipid and lipoprotein abnormalities, including elevation of both fasting and postprandial TG, apolipoprotein (Apo)A, or ApoB. The prevalence of dyslipidemia is getting severer worldwide. According to the 2015 Global Burden of Disease Study, the prevalence of elevated total cholesterol (TC) (≥200 mg/dL) was highest in the WHO European Region (54% for both sexes), followed by the WHO Region of the Americas (48% for both sexes). The WHO African Region and the WHO South-East Asia Region showed the lowest percentages (23% and 30%, respectively) [13]. In China, the prevalence of dyslipidemia was 42.8% overall [14], with 4.3%, 2.4%, 14.7%, and 17.4% for the age-standardized prevalence of high TC, LDL, TG, and HDL, respectively [15].
Evidence suggests that the development of T2DM was closely associated with lipid abnormality [16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26]. A study based on the 2010–2012 China National Nutrition and Health Survey (CNNHS) reported that the prevalence of dyslipidemia was 39.9%, 46.8%, and 59.3% in participants with normal glucose, prediabetes, and T2DM [16]. Zhu et al. ‘s meta-analysis reported that there were positive associations between different lipid parameters and T2DM. Moreover, the standardized mean difference for the Atherogenic index of plasma (AIP, lg(TG/HDL)) is 1.78 (95% confidence interval (CI): 1.04–2.52), which is higher than for other parameters (TG: 0.93, 95% CI: 0.78–1.09; TC: 0.46, 95% CI: 0.21–0.71; HDL-C: −0.89, 95%CI: −1.18 to −0.60; and LDL-C: 0.44, 95% CI: 0.11–0.77), suggesting AIP may be more closely associated with the risk of T2DM [9]. Results from the prospective cohort study (Multi-Ethnic Study of Atherosclerosis) found that elevated total ApoC-III concentrations were associated with a higher rate of diabetes, while ApoC-III-defined HDL subspecies displayed opposing associations: HDL lacking ApoC-III was inversely associated with incident diabetes, while no association was found for HDL containing ApoC-III. Further adjustment for plasma TG as a potential intermediate attenuated these associations [17]. Besides, not only baseline cross-sectional estimated or abnormal lipid level is related, Zheng et al. found that time-dependent TG/HDL ratios were also positively associated with future incident T2DM, which supports the change patterns for these parameters during the follow-up could intricate the development of diabetes [18]. Beshars et al. evaluated the relationship between diabetes and the increment in triglyceride levels within the normal range. Their results suggest that sustained increments in rising triglyceride levels, even within the accepted normal range, might pose a cumulative risk for the development of diabetes and impaired fasting glucose [19].
Despite the aforementioned epidemiologic evidence, the precise mechanisms of the associations are complex and remain unclear. Since the hallmark of T2DM is the inability of pancreatic beta-cells to produce adequate amounts of insulin, accompanied by reduced tissue responsiveness to insulin, also known as insulin resistance. Lipotoxicity caused by dyslipidemia plays an important role in the development and progression of insulin resistance [10]. It can disturb the utilization of insulin in peripheral target tissues (such as the liver), thus affecting the amount of lipids synthesis in the liver. So, elevated blood lipid can lead to insulin resistance, which in turn aggravates the generation of lipid metabolism disorder [27, 28, 29]. More recently, Seo et al. found that ApoJ is a novel hepatokine targeting muscle glucose metabolism and insulin sensitivity through low-density lipoprotein receptor-related protein-2 (LRP2)-dependent mechanism, coupled with the insulin receptor signaling cascade. In muscle, LRP2 is necessary for insulin receptor internalization, an initial trigger for insulin signaling, that is crucial in regulating downstream signaling and glucose uptake. Of physiologic significance, deletion of hepatic ApoJ or muscle LRP2 causes insulin resistance and glucose intolerance [30].
Lipid-lowering medication plays an essential role in the current healthcare system, not only for the optimization of the lipid profile but also to reduce cardiovascular risk [6, 12]. Recently, there is increased awareness of the possibility that lipid-lowering medications may affect glucose control and insulin resistance [31, 32, 33]. This phenomenon is reported in all classes of lipid-modifying agents, with differential effects of distinct drugs.
Some insights into this question emerged from some recent studies. Barak et al. systematically reviewed the related evidence and reported that both statins and niacin are associated with increased risk of impaired glucose control and development of new-onset diabetes, as opposed to bile-acid sequestrants which display concomitant moderate lipid and glucose-lowering effects, and fibrates (particularly the pan-PPAR agonist bezafibrate) which may produce beneficial effects on glucose metabolism and insulin sensitivity [34]. Another recently published meta-analysis, which included 163,688 nondiabetic patients from thirty-three randomized controlled trials, reported no significant association between 1-mmol/L reduction in LDL cholesterol and incident diabetes for statins or PCSK9 inhibitors. More intensive lipid-lowering therapy (defined as the more potent pharmacological strategy, such as PCSK9 inhibitors, higher intensity statins, or statins) was associated with a higher risk of incident diabetes compared with less intensive therapy (active control group or placebo/usual care of the trial). Meta-regression analysis suggested that these results were mainly driven by a higher risk of incident diabetes with statins, whereas PCSK9 inhibitors were not associated with incident diabetes (P = 0.02 for interaction). Thus, among intensive lipid-lowering therapies, there was no independent association between reduction in LDL cholesterol and incident diabetes [32].
The precise mechanisms for statin-induced diabetes remain unclear. However, several mechanisms have been proposed, including impaired insulin sensitivity, impaired insulin secretion, and compromised beta-cell function via enhanced intracellular cholesterol uptake due to inhibition of intracellular cholesterol synthesis by statins [34]. Recently, genetic studies have added more evidence to this. LDL-lowering alleles in
Diabetic dyslipidemia is a cluster of plasma lipid and lipoprotein abnormalities that are metabolically interrelated among diabetic patients. It is mainly characterized by increased TG levels, low HDL levels, and postprandial lipemia and contributes to the development of vascular complications [36]. Results from the 2010–2012 China National Nutrition and Health Survey (CNNHS) shown that the prevalence of dyslipidemia was 39.9%, 46.8%, and 59.3% in participants with normal glucose, prediabetes, and T2DM [16]. Another study using data from the 2010–2014 Diabetes Mellitus/Hypertension (DM/HT) study, which included 140,557 Thai adults with diabetes, reported that the dyslipidemia prevalence of 88.9% [37]. Despite the heterogeneity between different studies, the prevalence of diabetic dyslipidemia has grown gradually worldwide [4].
The pathophysiology of diabetic dyslipidemia is intricate and has not been fully understood [38]. Briefly speaking, changes in plasma lipoproteins among diabetic patients are affected by insufficient insulin function and hyperglycemia [39]. During the postprandial state, dietary fatty acids (FA) and cholesterol absorbed by the intestinal cells are incorporated as TG and cholesteryl esters into chylomicrons. In the capillary beds of adipocytes (especially in the fed state) and muscle, chylomicrons are the substrate for lipoprotein lipase (LPL), promoting lipolysis of chylomicrons TG and the release of FA. Insulin regulates LPL activity at several levels, including gene expression, protein synthesis, and secretion, and LPL is reduced in insulin-resistant individuals with T2DM with a consequent increase in plasma TG and decrease in HDL [40].
Both diabetes and dyslipidemia are important risk factors for CVD development, powered by the dyslipidemia-insulin resistance-hyperinsulinemia cycle [41]. This makes patients with diabetes dyslipidemia much more vulnerable to CVD outcomes. Results from the Multiple Risk Factor Intervention Trial (MRFIT) reported that among men who had diabetes at baseline, the absolute risk of coronary mortality at each level of blood cholesterol (for 20 mg/dL increments in TC starting from 180 mg/dL to >280 mg/dL), was 3–5 times higher in the presence of diabetes [42]. The United Kingdom Prospective Diabetes Study (UKPDS) has provided further evidence of a similarly direct and continuous association of coronary disease risk with LDL concentration. Among newly diagnosed T2DM, one mmol/L increase in LDL was associated with a 57% increased risk of myocardial infarction [43].
Many former studies have widely reported the causal association between dyslipidemia and CVD. Due to the rather complex components of lipid profile, diagnosis of diabetic dyslipidemia is not always revealed by the lipid measures used in clinical practice, as LDL levels may remain within the normal range. Therefore, it is suggested to use non-HDL levels to reflect the whole lipid spectrum [12]. The 2019 ESC/EAS Guidelines stated that ApoB analysis is recommended for risk assessment, particularly in people with high TG, diabetes, obesity, or metabolic syndrome. ApoB can be used as an alternative to LDL-C, if available, as the primary measurement for screening, diagnosis, and management [6].
Since a higher risk of atherosclerotic vascular disease in diabetic patients, lipid management has been recommended by diabetes-related clinical guidelines [3, 7, 8, 44, 45]. Consistent data have demonstrated the efficacy of statins, the first-choice lipid-lowering treatment, in preventing cardiovascular events and reducing cardiovascular mortality in patients with diabetes. A meta-analysis including 18,686 diabetic patients demonstrated that a statin-induced reduction of LDL by 1.0 mmol/L was associated with a 9% reduction in all-cause mortality and a 21% reduction in the incidence of major CV events [46]. The newly released ADA’s Standards of Medical Care in Diabetes-2020 has stated that statins should be used for both primary and secondary CVD prevention among diabetes. The detailed guideline are listed according to age groups: for 20–39 years-old diabetic patients with atherosclerotic cardiovascular disease risk factors, statin therapy is highly recommended in addition to lifestyle therapy; for patients with diabetes aged 40–75 years without atherosclerotic cardiovascular disease, use moderate-intensity statin therapy (lowers LDL by 30–49%) in addition to lifestyle therapy; while for patients aged 50–70 years with diabetes, high-intensity statin therapy (lowers LDL by ≥50%) is recommended [8]. The 2013 ACC/AHA guideline emphasized statin therapy recommended for all patients with diabetes 40 to 75 years of age-independent of baseline cholesterol [47].
Despite the CVD protective effect among diabetic patients, statin therapy has been associated with new-onset T2DM [31, 32]. A former study reported that for every 40 mmol/L reduction of LDL by statins, conversion to T2DM is increased by 10% [48, 49]. Nevertheless, the benefits in terms of cardiovascular event reduction greatly exceed the risks of statin therapy, and this has been confirmed in patients at low cardiovascular risk [46] (Tables 1 and 2).
Density (g/mL) | Diameter (nm) | TGs (%) | Cholesteryl esters (%) | PLs (%) | Cholesterol (%) | Apolipoproteins | ||
---|---|---|---|---|---|---|---|---|
Major | Others | |||||||
Chylomicrons | <0.95 | 80–100 | 90–95 | 2–4 | 2–6 | 1 | ApoB-48 | ApoA-I, A-II, A-IV, A-V |
VLDL | 0.95–1.006 | 30–80 | 50–65 | 8–14 | 12–16 | 4–7 | ApoB-100 | ApoA-I, C-II, C-III, E, A-V |
IDL | 1.006–1.019 | 25–30 | 25–40 | 20–35 | 16–24 | 7–11 | ApoB-100 | ApoC-II, C-III, E |
LDL | 1.019–1.063 | 20–25 | 4–6 | 34–35 | 22–26 | 6–15 | ApoB-100 | |
HDL | 1.063–1.210 | 8–13 | 7 | 10–20 | 55 | 5 | ApoA-I | ApoC-II, C-III, E, M |
Lp(a) | 1.006–1.125 | 25–30 | 4–8 | 35–46 | 17–24 | 6–9 | Apo(a) | ApoB-100 |
Physical and chemical characteristics of human plasma lipoproteins*.
Adapted from: “2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk.” By Mach F, Baigent C, Catapano AL, Koskinas KC, Casula M, Badimon L, et al. Eur Heart J. 2020;41 [1]:111–88.
Apo: apolipoprotein; HDL: high-density lipoprotein; IDL: intermediate-density lipoprotein; LDL: low-density lipoprotein; Lp(a): lipoprotein(a); PLs: phospholipids; TGs: triglycerides; VLDL: very-low-density lipoprotein.
For patients with diabetes aged 40–75 years without atherosclerotic cardiovascular disease, use moderate-intensity statin therapy in addition to lifestyle therapy. | ||
For patients with diabetes aged 20–39 years with additional atherosclerotic cardiovascular disease risk factors, it may be reasonable to initiate statin therapy in addition to lifestyle therapy. | ||
In patients with diabetes at higher risk, especially those with multiple atherosclerotic cardiovascular disease risk factors or aged 50–70 years, it is reasonable to use high-intensity statin therapy. | ||
In adults with diabetes and a 10-year atherosclerotic cardiovascular disease risk of 20% or higher, it may be reasonable to add ezetimibe to maximally tolerated statin therapy to reduce LDL cholesterol levels by 50% or more. | ||
In patients with T2D at moderate CV risk, an LDL-C target of <2.6 mmol/L (<100 mg/dL) is recommended. | Statins are recommended as the first-choice lipid-lowering treatment in patients with DM and high LDL-C levels: administration of statins is defined based on the CV risk profile of the patient and the recommended LDL-C (or non-HDL-C) target levels. | |
In patients with T2D at high CV risk, an LDL-C target of <1.8 mmol/L (<70 mg/dL) and LDL-C reduction of at least 50% is recommended. | ||
In patients with T2D at very high CV risk, an LDL-C target of <1.4 mmol/L (<55 mg/dL) and LDL-C reduction of at least 50% is recommended. | ||
The primary goal is to reduce LDL-C to the target (very high risk of ASCVD: <1.8 mmol/L, high risk of ASCVD: <2.6 mmol/L). | Statins are the preferred lipid-lowering drugs. Lipid-lowering therapy should start with a moderate-intensity statin, and the dose should be adjusted according to individual response to medication and tolerability. | |
LDL-C reduction by ≥50% may be used as an alternative target in the event of high baseline LDL-C and failure to reduce LDL-C to the target after 3 months of standard lipid-lowering therapy. | ||
The primary goal of antidyslipidemic therapy is to control the LDL-C level to <120 mg/dL in patients without a history of coronary artery disease. | Statins are the agents of choice for hyper-LDL-C in patients with diabetes. | |
The control goal for fasting triglyceride (TG) is <150 mg/dL. | ||
The control goal for HDL-C is ≥40 mg/dL. |
Guidelines for the management of diabetic dyslipidemia using statin.
Complex lipoprotein metabolism abnormalities could present both in the development and progression of type 2 diabetes, which indicates that lipid management can prevent cardiovascular complications among diabetic patients and involve in the prevention of diabetes. Epidemiological studies suggest that lipid components could be a marker for diabetes prediction, though it is still uncertain which lipid markers are of the most clinical value. Lipid control using a lipid-lowering medication, such as statins, could reduce CVD risk among the general population also diabetic people. However, it is necessary to consider statin diabetogenicity in clinical practice when the statin is indicated.
The authors declare no conflict of interest.
As this section deals with legal issues pertaining to the rights of individual Authors and IntechOpen, for the avoidance of doubt, each category of publication is dealt with separately. Consequently, much of the information, for example definition of terms used, is repeated to ensure that there can be no misunderstanding of the policies that apply to each category.
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\\n\\nHOW COPYRIGHT WORKS WITH OPEN ACCESS LICENSES?
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\\n\\nAll Works published on the IntechOpen platform and in print are licensed under a Creative Commons Attribution 3.0 Unported and Creative Commons 4.0 International License, a license which allows for the broadest possible reuse of published material.
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The CC BY 3.0 and CC BY 4.0 license permits Works to be freely shared in any medium or format, as well as the reuse and adaptation of the original contents of Works (e.g. figures and tables created by the Authors), as long as the source Work is cited and its Authors are acknowledged in the following manner:
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\\n\\nAll rights to Books and Journals and all other compilations published on the IntechOpen platform and in print are reserved by IntechOpen.
\\n\\nThe copyright to Books, Journals and other compilations is subject to separate copyright from those that exist in the included Works.
\\n\\nAll Long Form Monographs/Compacts are licensed under the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) license granted to all others.
\\n\\nCopyright to the individual Works (Chapters) belongs to their specific Authors, subject to an agreement with IntechOpen and the Creative Common license granted to all others to:
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\\n\\nNonCommercial - The use of the material for commercial purposes is prohibited. Commercial rights are reserved to IntechOpen or its licensees.
\\n\\nNo additional restrictions that apply legal terms or technological measures that restrict others from doing anything the license permits are allowed.
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\\n\\nEvery reproduction of a front cover image must be accompanied by an appropriate Copyright Notice displayed adjacent to the image. The exact Copyright Notice depends on who the Author of a particular cover image is. Users wishing to reproduce cover images should contact permissions@intechopen.com.
\\n\\nAll Video Lectures under IntechOpen's production are subject to copyright and are property of IntechOpen, unless defined otherwise, and are licensed under the Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license. This grants all others the right to:
\\n\\nShare — copy and redistribute the material in any medium or format
\\n\\nUnder the following terms:
\\n\\nUsers wishing to repost and share the Video Lectures are welcome to do so as long as they acknowledge the source in the following manner:
\\n\\n© {year} IntechOpen. Published under CC BY-NC-ND 4.0 license. Available from: {DOI}
\\n\\nUsers wishing to reuse, modify, or adapt the Video Lectures in a way not permitted by the license are welcome to contact us at permissions@intechopen.com to discuss waiving particular license terms.
\\n\\nAll software used on the IntechOpen platform, any used during the publishing process, and the copyright in the code constituting such software, is the property of IntechOpen or its software suppliers. As such, it may not be downloaded or copied without permission.
\\n\\nUnless otherwise indicated, all IntechOpen websites are the property of IntechOpen.
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\\n"}]'},components:[{type:"htmlEditorComponent",content:'Copyright is the term used to describe the rights related to the publication and distribution of original Works. Most importantly from a publisher's perspective, copyright governs how Authors, publishers and the general public can use, publish, and distribute publications.
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\n\nHOW COPYRIGHT WORKS WITH OPEN ACCESS LICENSES?
\n\nAgreement samples are listed here for the convenience of prospective Authors:
\n\nDEFINITIONS
\n\nThe following definitions apply in this Copyright Policy:
\n\nAuthor - in order to be identified as an Author, three criteria must be met: (i) Substantial contribution to the conception or design of the Work, or the acquisition, analysis, or interpretation of data for the Work; (ii) Participation in drafting or revising the Work; (iii) Approval of the final version of the Work to be published.
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\n\nCompilation - a collection of Works distributed in a Book that IntechOpen has selected, and for which the coordination of the preparation, arrangement and publication has been the responsibility of IntechOpen. Any Work included is accepted in its entirety in unmodified form and is published with one or more other contributions, each constituting a separate and independent Work, but which together are assembled into a collective whole.
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\n\nIntechOpen - Registered publisher with office at 5 Princes Gate Court, London, SW7 2QJ - UNITED KINGDOM
\n\nIntechOpen platform - IntechOpen website www.intechopen.com whose main purpose is to host Monographs in the format of Book Chapters, Long Form Monographs, Compacts, Conference Proceedings, Scientific Journals and Videos.
\n\nVideo Lecture – an audiovisual recording of a lecture or a speech given by a Lecturer, recorded, edited, owned and published by IntechOpen.
\n\nTERMS
\n\nAll Works published on the IntechOpen platform and in print are licensed under a Creative Commons Attribution 3.0 Unported and Creative Commons 4.0 International License, a license which allows for the broadest possible reuse of published material.
\n\nCopyright on the individual Works belongs to the specific Author, subject to an agreement with IntechOpen. The Creative Common license is granted to all others to:
\n\nAnd for any purpose, provided the following conditions are met:
\n\nAll Works are published under the CC BY 3.0 and CC BY 4.0 license. However, please note that book Chapters may fall under a different CC license, depending on their publication date as indicated in the table below:
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LICENSE | \n\t\t\tUSED FROM - | \n\t\t\tUP TO - | \n\t\t
\n\t\t\t Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported (CC BY-NC-SA 3.0) \n\t\t\t | \n\t\t\t1 July 2005 (2005-07-01) | \n\t\t\t3 October 2011 (2011-10-03) | \n\t\t
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The CC BY 3.0 and CC BY 4.0 license permits Works to be freely shared in any medium or format, as well as the reuse and adaptation of the original contents of Works (e.g. figures and tables created by the Authors), as long as the source Work is cited and its Authors are acknowledged in the following manner:
\n\nContent reuse:
\n\n© {year} {authors' full names}. Originally published in {short citation} under {license version} license. Available from: {DOI}
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\n\n© {year} {authors' full names}. Adapted from {short citation}; originally published under {license version} license. Available from: {DOI}
\n\nReposting & sharing:
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\n\nRepublishing – More about Attribution Policy can be found here.
\n\nThe same principles apply to Works published under the CC BY-NC-SA 3.0 license, with the caveats that (1) the content may not be used for commercial purposes, and (2) derivative works building on this content must be distributed under the same license. The restrictions contained in these license terms may, however, be waived by the copyright holder(s). Users wishing to circumvent any of the license terms are required to obtain explicit permission to do so from the copyright holder(s).
\n\nDISCLAIMER: Neither the CC BY 3.0 license, CC BY 4.0, nor any other license IntechOpen currently uses or has used before, applies to figures and tables reproduced from other works, as they may be subject to different terms of reuse. In such cases, if the copyright holder is not noted in the source of a figure or table, it is the responsibility of the User to investigate and determine the exact copyright status of any information utilised. Users requiring assistance in that regard are welcome to send an inquiry to permissions@intechopen.com.
\n\nAll rights to Books and Journals and all other compilations published on the IntechOpen platform and in print are reserved by IntechOpen.
\n\nThe copyright to Books, Journals and other compilations is subject to separate copyright from those that exist in the included Works.
\n\nAll Long Form Monographs/Compacts are licensed under the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) license granted to all others.
\n\nCopyright to the individual Works (Chapters) belongs to their specific Authors, subject to an agreement with IntechOpen and the Creative Common license granted to all others to:
\n\nUnder the following terms:
\n\nThere must be an Attribution, giving appropriate credit, provision of a link to the license, and indication if any changes were made.
\n\nNonCommercial - The use of the material for commercial purposes is prohibited. Commercial rights are reserved to IntechOpen or its licensees.
\n\nNo additional restrictions that apply legal terms or technological measures that restrict others from doing anything the license permits are allowed.
\n\nThe CC BY-NC 4.0 license permits Works to be freely shared in any medium or format, as well as reuse and adaptation of the original contents of Works (e.g. figures and tables created by the Authors), as long as it is not used for commercial purposes. The source Work must be cited and its Authors acknowledged in the following manner:
\n\nContent reuse:
\n\n© {year} {authors' full names}. Originally published in {short citation} under {license version} license. Available from: {DOI}
\n\nContent adaptation & reuse:
\n\n© {year} {authors' full names}. Adapted from {short citation}; originally published under {license version} license. Available from: {DOI}
\n\nReposting & sharing:
\n\nOriginally published in {full citation}. Available from: {DOI}
\n\nAll Book cover design elements, as well as Video image graphics are subject to copyright by IntechOpen.
\n\nEvery reproduction of a front cover image must be accompanied by an appropriate Copyright Notice displayed adjacent to the image. The exact Copyright Notice depends on who the Author of a particular cover image is. Users wishing to reproduce cover images should contact permissions@intechopen.com.
\n\nAll Video Lectures under IntechOpen's production are subject to copyright and are property of IntechOpen, unless defined otherwise, and are licensed under the Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license. This grants all others the right to:
\n\nShare — copy and redistribute the material in any medium or format
\n\nUnder the following terms:
\n\nUsers wishing to repost and share the Video Lectures are welcome to do so as long as they acknowledge the source in the following manner:
\n\n© {year} IntechOpen. Published under CC BY-NC-ND 4.0 license. Available from: {DOI}
\n\nUsers wishing to reuse, modify, or adapt the Video Lectures in a way not permitted by the license are welcome to contact us at permissions@intechopen.com to discuss waiving particular license terms.
\n\nAll software used on the IntechOpen platform, any used during the publishing process, and the copyright in the code constituting such software, is the property of IntechOpen or its software suppliers. As such, it may not be downloaded or copied without permission.
\n\nUnless otherwise indicated, all IntechOpen websites are the property of IntechOpen.
\n\nAll content included on IntechOpen Websites not forming part of contributed materials (such as text, images, logos, graphics, design elements, videos, sounds, pictures, trademarks, etc.), are subject to copyright and are property of, or licensed to, IntechOpen. Any other use, including the reproduction, modification, distribution, transmission, republication, display, or performance of the content on this site is strictly prohibited.
\n\nPolicy last updated: 2016-06-08
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His studies in robotics lead him not only to a PhD degree but also inspired him to co-found and build the International Journal of Advanced Robotic Systems - world's first Open Access journal in the field of robotics.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"441",title:"Ph.D.",name:"Jaekyu",middleName:null,surname:"Park",slug:"jaekyu-park",fullName:"Jaekyu Park",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/441/images/1881_n.jpg",biography:null,institutionString:null,institution:{name:"LG Corporation (South Korea)",country:{name:"Korea, South"}}},{id:"465",title:"Dr.",name:"Christian",middleName:null,surname:"Martens",slug:"christian-martens",fullName:"Christian Martens",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Rheinmetall (Germany)",country:{name:"Germany"}}},{id:"479",title:"Dr.",name:"Valentina",middleName:null,surname:"Colla",slug:"valentina-colla",fullName:"Valentina Colla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/479/images/358_n.jpg",biography:null,institutionString:null,institution:{name:"Sant'Anna School of Advanced Studies",country:{name:"Italy"}}},{id:"494",title:"PhD",name:"Loris",middleName:null,surname:"Nanni",slug:"loris-nanni",fullName:"Loris Nanni",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/494/images/system/494.jpg",biography:"Loris Nanni received his Master Degree cum laude on June-2002 from the University of Bologna, and the April 26th 2006 he received his Ph.D. in Computer Engineering at DEIS, University of Bologna. On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. His research interests include pattern recognition, bioinformatics, and biometric systems (fingerprint classification and recognition, signature verification, face recognition).",institutionString:null,institution:null},{id:"496",title:"Dr.",name:"Carlos",middleName:null,surname:"Leon",slug:"carlos-leon",fullName:"Carlos Leon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Seville",country:{name:"Spain"}}},{id:"512",title:"Dr.",name:"Dayang",middleName:null,surname:"Jawawi",slug:"dayang-jawawi",fullName:"Dayang Jawawi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Technology Malaysia",country:{name:"Malaysia"}}},{id:"528",title:"Dr.",name:"Kresimir",middleName:null,surname:"Delac",slug:"kresimir-delac",fullName:"Kresimir Delac",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/528/images/system/528.jpg",biography:"K. Delac received his B.Sc.E.E. degree in 2003 and is currentlypursuing a Ph.D. degree at the University of Zagreb, Faculty of Electrical Engineering andComputing. His current research interests are digital image analysis, pattern recognition andbiometrics.",institutionString:null,institution:{name:"University of Zagreb",country:{name:"Croatia"}}},{id:"557",title:"Dr.",name:"Andon",middleName:"Venelinov",surname:"Topalov",slug:"andon-topalov",fullName:"Andon Topalov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/557/images/1927_n.jpg",biography:"Dr. Andon V. Topalov received the MSc degree in Control Engineering from the Faculty of Information Systems, Technologies, and Automation at Moscow State University of Civil Engineering (MGGU) in 1979. He then received his PhD degree in Control Engineering from the Department of Automation and Remote Control at Moscow State Mining University (MGSU), Moscow, in 1984. From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. His current research interests are in the fields of intelligent control and robotics.",institutionString:null,institution:{name:"Technical University of Sofia",country:{name:"Bulgaria"}}},{id:"585",title:"Prof.",name:"Munir",middleName:null,surname:"Merdan",slug:"munir-merdan",fullName:"Munir Merdan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/585/images/system/585.jpg",biography:"Munir Merdan received the M.Sc. degree in mechanical engineering from the Technical University of Sarajevo, Bosnia and Herzegovina, in 2001, and the Ph.D. degree in electrical engineering from the Vienna University of Technology, Vienna, Austria, in 2009.Since 2005, he has been at the Automation and Control Institute, Vienna University of Technology, where he is currently a Senior Researcher. His research interests include the application of agent technology for achieving agile control in the manufacturing environment.",institutionString:null,institution:null},{id:"605",title:"Prof",name:"Dil",middleName:null,surname:"Hussain",slug:"dil-hussain",fullName:"Dil Hussain",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/605/images/system/605.jpg",biography:"Dr. Dil Muhammad Akbar Hussain is a professor of Electronics Engineering & Computer Science at the Department of Energy Technology, Aalborg University Denmark. Professor Akbar has a Master degree in Digital Electronics from Govt. College University, Lahore Pakistan and a P-hD degree in Control Engineering from the School of Engineering and Applied Sciences, University of Sussex United Kingdom. Aalborg University has Two Satellite Campuses, one in Copenhagen (Aalborg University Copenhagen) and the other in Esbjerg (Aalborg University Esbjerg).\n· He is a member of prestigious IEEE (Institute of Electrical and Electronics Engineers), and IAENG (International Association of Engineers) organizations. \n· He is the chief Editor of the Journal of Software Engineering.\n· He is the member of the Editorial Board of International Journal of Computer Science and Software Technology (IJCSST) and International Journal of Computer Engineering and Information Technology. \n· He is also the Editor of Communication in Computer and Information Science CCIS-20 by Springer.\n· Reviewer For Many Conferences\nHe is the lead person in making collaboration agreements between Aalborg University and many universities of Pakistan, for which the MOU’s (Memorandum of Understanding) have been signed.\nProfessor Akbar is working in Academia since 1990, he started his career as a Lab demonstrator/TA at the University of Sussex. After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. 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