Comparison between the 3rd and the 4th WHO classification of pituitary adenomas.
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Barely three months into the new year and we are happy to announce a monumental milestone reached - 150 million downloads.
\n\nThis achievement solidifies IntechOpen’s place as a pioneer in Open Access publishing and the home to some of the most relevant scientific research available through Open Access.
\n\nWe are so proud to have worked with so many bright minds throughout the years who have helped us spread knowledge through the power of Open Access and we look forward to continuing to support some of the greatest thinkers of our day.
\n\nThank you for making IntechOpen your place of learning, sharing, and discovery, and here’s to 150 million more!
\n\n\n\n\n'}],latestNews:[{slug:"intechopen-supports-asapbio-s-new-initiative-publish-your-reviews-20220729",title:"IntechOpen Supports ASAPbio’s New Initiative Publish Your Reviews"},{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"}]},book:{item:{type:"book",id:"6103",leadTitle:null,fullTitle:"Highway Engineering",title:"Highway Engineering",subtitle:null,reviewType:"peer-reviewed",abstract:"Highway engineering is an engineering discipline branching from civil engineering that involves the planning, design, construction, operation, and maintenance of roads, bridges, and tunnels to ensure safe and effective transportation of people and goods. The book Highway Engineering includes the main topics and the basic principles of highway engineering and provides the full scope of current information necessary for effective and cost-conscious contemporary highway. The book reflects new engineering and building developments, the most current design methods, as well as the latest industry standards and policies. This book provides a comprehensive overview of significant characteristics for highway engineering. It highlights recent advancements, requirements, and improvements and details the latest techniques in the global market. Highway Engineering contains a collection of the latest research developments on highway engineering. This book comprehensively covers the basic theory and practice in sufficient depth to provide a solid grounding to highway engineers. This book helps readers maximize effectiveness in all facets of highway engineering. This professional book as a credible source and a valuable reference can be very applicable and useful for all professors, researchers, engineers, practicing professionals, trainee practitioners, students, and others interested in highway projects.",isbn:"978-953-51-3670-5",printIsbn:"978-953-51-3669-9",pdfIsbn:"978-953-51-4582-0",doi:"10.5772/intechopen.68229",price:119,priceEur:129,priceUsd:155,slug:"highway-engineering",numberOfPages:114,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"9c66d18cec90a84fdfd9a64451dc421a",bookSignature:"Hamid Yaghoubi",publishedDate:"December 6th 2017",coverURL:"https://cdn.intechopen.com/books/images_new/6103.jpg",numberOfDownloads:8871,numberOfWosCitations:7,numberOfCrossrefCitations:5,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:10,numberOfDimensionsCitationsByBook:0,hasAltmetrics:0,numberOfTotalCitations:22,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"April 13th 2017",dateEndSecondStepPublish:"May 4th 2017",dateEndThirdStepPublish:"July 31st 2017",dateEndFourthStepPublish:"October 29th 2017",dateEndFifthStepPublish:"December 28th 2017",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6,7",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"103965",title:"Dr.",name:"Hamid",middleName:null,surname:"Yaghoubi",slug:"hamid-yaghoubi",fullName:"Hamid Yaghoubi",profilePictureURL:"https://mts.intechopen.com/storage/users/103965/images/system/103965.jpeg",biography:"Dr. Hamid Yaghoubi is the director of Iran Maglev Technology (IMT). He became the Iran top researcher in 2010. In this regard, he was awarded by the Iranian president; the Iranian Minister of Science, Research and Technology; and the Iranian Minister of Information and Communication Technology. He became the 2011 and 2012 Outstanding Reviewer for the Journal of Transportation Engineering (JTE), American Society of Civil Engineers (ASCE), USA. One of his journal papers became the 2011 Top Download Paper for JTE. He received the ICCTP2011 Award for the 11th International Conference of Chinese Transportation Professionals (ICCTP2011), ASCE. He is an assistant chief editor and an editorial board member for some journals. He has been a reviewer for the majority of journals, books and conferences. He has also been an editor for some books. He has cooperated with hundreds of international conferences as a chairman, a keynote speaker, a chair of session, a publication chair, and a member of committees, including scientific, organizing, steering, advisory, technical program, and so on. He is also a member of several international committees.",institutionString:"Iran Maglev Technology (IMT)",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"3",totalChapterViews:"0",totalEditedBooks:"4",institution:{name:"Iran University of Science and Technology",institutionURL:null,country:{name:"Iran"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"709",title:"Highway Engineering",slug:"highway-engineering"}],chapters:[{id:"57083",title:"Reserve Capacity Model for Optimizing Traffic Signal Timings with an Equity Constraint",doi:"10.5772/intechopen.70883",slug:"reserve-capacity-model-for-optimizing-traffic-signal-timings-with-an-equity-constraint",totalDownloads:1429,totalCrossrefCites:4,totalDimensionsCites:4,hasAltmetrics:0,abstract:"This paper represents a solution algorithm for optimizing traffic signal timings in urban road networks by considering reserve capacity with an equity constraint. It is well known that the variation of signal timings in a road network may cause an inequity issue with regard to the travel costs of road users travelling between origin-destination (O-D) pairs. That is, the users may be influenced differently by changing traffic signal timings. In this context, the bilevel programming model is proposed for finding reserve capacity for signalized road networks by taking into account the equity issue. In the upper level, the reserve capacity is maximized with an equity constraint, whereas deterministic user equilibrium problem is dealt in the lower level. In order to solve the proposed model, a heuristic solution algorithm based on harmony search combined with a penalty function approach is developed. The application of the proposed model is illustrated for an example road network taken from a literature.",signatures:"Ozgur Baskan and Cenk Ozan",downloadPdfUrl:"/chapter/pdf-download/57083",previewPdfUrl:"/chapter/pdf-preview/57083",authors:[{id:"15540",title:"Prof.",name:"Ozgur",surname:"Baskan",slug:"ozgur-baskan",fullName:"Ozgur Baskan"},{id:"207460",title:"Dr.",name:"Cenk",surname:"Ozan",slug:"cenk-ozan",fullName:"Cenk Ozan"}],corrections:null},{id:"56756",title:"Effects on the Design of Transport Systems of Pedestrian Dynamics",doi:"10.5772/intechopen.70496",slug:"effects-on-the-design-of-transport-systems-of-pedestrian-dynamics",totalDownloads:1582,totalCrossrefCites:1,totalDimensionsCites:4,hasAltmetrics:1,abstract:"In the study, transportation-architecture-people-focused triple, urban transportation, design of transportation systems, pedestrian-oriented design and pedestrian walkable spaces will be emphasized. However, by analyzing the effects of pedestrian dynamics, transport systems aim to present a mechanism with an improved model that will define dynamics for the first time to explain the processes underlying design decisions. Four hundred and twelve healthy volunteers were selected from 18–65 years of age. First, three-dimensional (3D) virtual city is designed to understand the experiences of the pedestrians. Later, it was provided to navigate the three-dimensional virtual glasses in the city where the broadcasts were designed. During this navigation, pedestrian dynamics were observed, and spaces where pedestrians cautioned were identified. Following this determination, the “attractive” locations will be shown on the macroscale, with the eye-tracking method, it has been in both virtual city navigation and analysis with eye-tracking technology, the cognitive activities of the broadcasts were tested with electroencephalogram (EEG). This approach will in general bridge an empirical and theoretical link between transport-architectural literature in understanding pedestrian movements/behaviors and combining architectural-pedestrian interactions with transport research. However, by analyzing the way-finding behavior, the study interprets its effects on the spatial area.",signatures:"İlker Erkan",downloadPdfUrl:"/chapter/pdf-download/56756",previewPdfUrl:"/chapter/pdf-preview/56756",authors:[{id:"206561",title:"Dr.",name:"Ilker",surname:"Erkan",slug:"ilker-erkan",fullName:"Ilker Erkan"}],corrections:null},{id:"57087",title:"Analysis of Highway Acceleration in Regard to Cargo Security",doi:"10.5772/intechopen.70829",slug:"analysis-of-highway-acceleration-in-regard-to-cargo-security",totalDownloads:1454,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Cargo security during road transportation particularly presents a current topic in the context of transport safety. One of the key factors influencing the magnitude of impact (acceleration coefficients) during transportation is the quality of the road networks. Acceleration coefficient values directly affect the rate of inertia forces influencing the cargo. Given that the inertia force magnitudes (acceleration coefficients) are not known prior to commencing the actual transport, acceleration coefficient values known from regulations or otherwise (for example, empirically) certain established values must be used. Values of acceleration coefficients were established in EN 12195–1, a regulation typically used within the European Union. This chapter covers the approaches of this standard and provides comparison of acceleration coefficients established through regulations with those measured. Data (coefficient acceleration) from both highway transport and unpaved roads (in off-road conditions) were measured and statistically processed for comparison purposes. The transportation model presented subsequently demonstrates differences in the magnitude of inertia forces using three sets of data—acceleration coefficients obtained from the standard, from highway transport, and from off-road transport. At the same time, these secured cargoes were set into an insufficient context, where unsuitable or insufficient security of the cargo represents one of the significant risks in the occurrence of an accident.",signatures:"Martin Vlkovský",downloadPdfUrl:"/chapter/pdf-download/57087",previewPdfUrl:"/chapter/pdf-preview/57087",authors:[{id:"207708",title:"Ph.D.",name:"Martin",surname:"Vlkovský",slug:"martin-vlkovsky",fullName:"Martin Vlkovský"}],corrections:null},{id:"57709",title:"Joint Road Safety Analysis in Open Roads and Tunnels",doi:"10.5772/intechopen.71734",slug:"joint-road-safety-analysis-in-open-roads-and-tunnels",totalDownloads:1290,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"From the user’s (drivers) point of view, a road is a unique linear infrastructure although it is clear for a driver that such a linear infrastructure consists of open terrain (open roads) and occasionally closed environment (tunnels). Since the two environments present different safety issues, the related analyses are usually conducted on the field by different experts; those conclusions are sometimes not well interlinked and harmonised, leading to safety gaps particularly, but not only, in the transition areas. Joint safety analyses conducted in the same time by a group of road safety and tunnel safety experts can fill such a gap and increase the safety level of the whole infrastructure. During the year 2016, an international group of road safety experts and tunnel experts visited five road sections with open roads and tunnel in Europe and performed joint safety analyses together with the infrastructure managers. Such analyses were conducted according to a predefined experimental procedure to check the effectiveness of the joint analyses with respect to the usual ones. The key results are that joint safety operations in tunnels and open roads are possible and extremely useful: their cost can be very low when well planned.",signatures:"Carlo Polidori, Adewole Adesiyun, Antonio Avenoso, Kallistratos\nDionelis, Liljana Cela, Christophe Nicodème and Thierry Goger",downloadPdfUrl:"/chapter/pdf-download/57709",previewPdfUrl:"/chapter/pdf-preview/57709",authors:[{id:"206556",title:"Dr.Ing.",name:"Carlo",surname:"Polidori",slug:"carlo-polidori",fullName:"Carlo Polidori"},{id:"207601",title:"Dr.",name:"Adewole",surname:"Adesiyun",slug:"adewole-adesiyun",fullName:"Adewole Adesiyun"},{id:"207602",title:"Dr.",name:"Liljana",surname:"Cela",slug:"liljana-cela",fullName:"Liljana Cela"},{id:"207603",title:"Mr.",name:"Antonio",surname:"Avenoso",slug:"antonio-avenoso",fullName:"Antonio Avenoso"},{id:"207604",title:"Dr.",name:"Christophe",surname:"Nicodème",slug:"christophe-nicodeme",fullName:"Christophe Nicodème"},{id:"207605",title:"Mr.",name:"Kallistratos",surname:"Dionelis",slug:"kallistratos-dionelis",fullName:"Kallistratos Dionelis"}],corrections:null},{id:"57639",title:"Empowering Added Value in Highway Project: A Strategy to Improve the Feasibility",doi:"10.5772/intechopen.71778",slug:"empowering-added-value-in-highway-project-a-strategy-to-improve-the-feasibility",totalDownloads:1572,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Most mega-project infrastructure such as highway construction requires an enormous amount of cost. This situation might be a problem to developing countries that have limited national budget plan. On the other hand, the capability to transfer the funding of infrastructure depends on the project attractiveness to the private sector. The evaluation to involve in the project should be supported by a significant value for money from the business perspective. Optimum feasibility plays a vital role in bridging the partnership between the government and private interests. The study uses a case study of highway project development of Trans-Sumatera highway road (TSHR) that spans about 2700 km to elaborate on how project feasibility can be improved through creative method. Value engineering (VE) approach as a systematic way to generate innovative ideas by combining multidiscipline backgrounds perspective is used. The study shows that additional functions for the project include integration with motorbike toll road, dry port, and railway line; others also include tourism, fiber optic, and service area development. The innovative ideas have contributed to the significant increase in the internal rate of return (IRR) to the project from 7.79 to 12.76%. The study also formulates institutional scheme through build operate sharing transfer (BOST) which administers government’s role in the project development.",signatures:"Mohammed Ali Berawi",downloadPdfUrl:"/chapter/pdf-download/57639",previewPdfUrl:"/chapter/pdf-preview/57639",authors:[{id:"207251",title:"Dr.",name:"Mohammed Ali",surname:"Berawi",slug:"mohammed-ali-berawi",fullName:"Mohammed Ali Berawi"}],corrections:null},{id:"57612",title:"Nondestructive Tests in Highway Engineering",doi:"10.5772/intechopen.71615",slug:"nondestructive-tests-in-highway-engineering",totalDownloads:1544,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"In highway engineering, one needs to know the information about the thickness and elastic modulus of each pavement layer. The thickness and elastic modulus of each pavement component then become input to elasticity analysis or finite element computation to calculate the service life of the highway. An application was Multichannel Analysis of Surface Waves (MASW) measurement on highway in North Jakarta. The measurement was carried out on highway traffic, because we were not allowed to stop traffic of one of the busiest roads in Jakarta. The street is heading to Tanjung Priok, the port of Jakarta. However, we acquired fairly good data by applying stacking method. The number of stacking was 10 (ten) to overcome traffic noise. After inversion, we came up with the result of MASW measurement of the pavement. The result of MASW measurement in terms of elastic modulus and thicknesses of pavement layer becomes important input of finite element analysis to compute fatigue damage of pavement components.",signatures:"Gunawan Handayani",downloadPdfUrl:"/chapter/pdf-download/57612",previewPdfUrl:"/chapter/pdf-preview/57612",authors:[{id:"206588",title:"Ph.D.",name:"Gunawan",surname:"Handayani",slug:"gunawan-handayani",fullName:"Gunawan Handayani"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"5423",title:"Urban Transport Systems",subtitle:null,isOpenForSubmission:!1,hash:"222b5d90a7014dbff7e33f3dcde6bc1d",slug:"urban-transport-systems",bookSignature:"Hamid Yaghoubi",coverURL:"https://cdn.intechopen.com/books/images_new/5423.jpg",editedByType:"Edited by",editors:[{id:"103965",title:"Dr.",name:"Hamid",surname:"Yaghoubi",slug:"hamid-yaghoubi",fullName:"Hamid Yaghoubi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6395",title:"Bridge Engineering",subtitle:null,isOpenForSubmission:!1,hash:"1d5fcf0ef5708024ef95eb8b3d7310be",slug:"bridge-engineering",bookSignature:"Hamid Yaghoubi",coverURL:"https://cdn.intechopen.com/books/images_new/6395.jpg",editedByType:"Edited by",editors:[{id:"103965",title:"Dr.",name:"Hamid",surname:"Yaghoubi",slug:"hamid-yaghoubi",fullName:"Hamid Yaghoubi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7524",title:"High-Speed Rail",subtitle:null,isOpenForSubmission:!1,hash:"0e248745ed8a460687701d02462cb874",slug:"high-speed-rail",bookSignature:"Hamid Yaghoubi",coverURL:"https://cdn.intechopen.com/books/images_new/7524.jpg",editedByType:"Edited by",editors:[{id:"103965",title:"Dr.",name:"Hamid",surname:"Yaghoubi",slug:"hamid-yaghoubi",fullName:"Hamid Yaghoubi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8747",title:"Asphalt and Asphalt Mixtures",subtitle:null,isOpenForSubmission:!1,hash:"6083f7c9881029f1e033a1e512af7e20",slug:"asphalt-and-asphalt-mixtures",bookSignature:"Haitao Zhang",coverURL:"https://cdn.intechopen.com/books/images_new/8747.jpg",editedByType:"Edited by",editors:[{id:"260604",title:"Prof.",name:"Haitao",surname:"Zhang",slug:"haitao-zhang",fullName:"Haitao Zhang"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. 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Lewis",slug:"elfed-lewis",email:"Elfed.Lewis@ul.ie",position:null,institution:{name:"University of Limerick",institutionURL:null,country:{name:"Ireland"}}},{id:"259703",title:"Dr.",name:"Dinesh Babu",middleName:null,surname:"Duraibabu",fullName:"Dinesh Babu Duraibabu",slug:"dinesh-babu-duraibabu",email:"dineshbabu.duraibabu@ul.ie",position:null,institution:{name:"University of Limerick",institutionURL:null,country:{name:"Ireland"}}},{id:"269578",title:"Dr.",name:"Gabriel",middleName:null,surname:"Leen",fullName:"Gabriel Leen",slug:"gabriel-leen",email:"Gabriel.Leen@ul.ie",position:null,institution:{name:"University of Limerick",institutionURL:null,country:{name:"Ireland"}}},{id:"269579",title:"M.Sc.",name:"Fintan",middleName:null,surname:"McGuinness",fullName:"Fintan McGuinness",slug:"fintan-mcguinness",email:"Fintan.McGuinness@ul.ie",position:null,institution:{name:"University of 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3.0",editedByType:"Edited by",editors:[{id:"220902",title:"Dr.",name:"Christian",middleName:null,surname:"Cuadrado-Laborde",slug:"christian-cuadrado-laborde",fullName:"Christian Cuadrado-Laborde"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"27036",title:"Dr.",name:"Daniel",middleName:null,surname:"Toal",fullName:"Daniel Toal",slug:"daniel-toal",email:"daniel.toal@ul.ie",position:null,institution:{name:"University of Limerick",institutionURL:null,country:{name:"Ireland"}}},{id:"85846",title:"Prof.",name:"Elfed",middleName:null,surname:"Lewis",fullName:"Elfed Lewis",slug:"elfed-lewis",email:"Elfed.Lewis@ul.ie",position:null,institution:{name:"University of Limerick",institutionURL:null,country:{name:"Ireland"}}},{id:"259703",title:"Dr.",name:"Dinesh Babu",middleName:null,surname:"Duraibabu",fullName:"Dinesh Babu Duraibabu",slug:"dinesh-babu-duraibabu",email:"dineshbabu.duraibabu@ul.ie",position:null,institution:{name:"University of Limerick",institutionURL:null,country:{name:"Ireland"}}},{id:"269578",title:"Dr.",name:"Gabriel",middleName:null,surname:"Leen",fullName:"Gabriel Leen",slug:"gabriel-leen",email:"Gabriel.Leen@ul.ie",position:null,institution:{name:"University of Limerick",institutionURL:null,country:{name:"Ireland"}}},{id:"269579",title:"M.Sc.",name:"Fintan",middleName:null,surname:"McGuinness",fullName:"Fintan McGuinness",slug:"fintan-mcguinness",email:"Fintan.McGuinness@ul.ie",position:null,institution:{name:"University of Limerick",institutionURL:null,country:{name:"Ireland"}}},{id:"269580",title:"Dr.",name:"Gerard",middleName:null,surname:"Dooly",fullName:"Gerard Dooly",slug:"gerard-dooly",email:"Gerard.Dooly@ul.ie",position:null,institution:{name:"University of Limerick",institutionURL:null,country:{name:"Ireland"}}}]},book:{id:"8271",title:"Applications of Optical Fibers for 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\r\n\tChronic Obstructive Pulmonary Disease (COPD) is an age-old ailment that has plagued humankind since eons ago. The epidemic of COPD is largely caused by cigarette smoking and air pollution. COPD is an illness that does not respect the culture, geography, socio-economic status, or education. Consequently, it is a highly prevalent disease worldwide. Notwithstanding the current viral pandemic which has been ravaging the world, the health burden of COPD remains high, especially in low and middle-income countries. Confronting COPD is straining healthcare resources and involves a plethora of healthcare personnel from diverse backgrounds and disciplines. Thus, an educational resource for COPD necessitates an inter-disciplinary and multi-disciplinary approach to be considered comprehensive.
\r\n\r\n\tThis book aims to provide such a perspective. From bench to bedside and beyond, this compendium of publications on COPD seeks to provide clinicians as well as non-clinicians a multi-faceted view of a truly global disease. The renaissance of humanistic perspectives of medicine is intended to provide interesting aspects of dealing with this ancient and global malady.
",isbn:"978-1-80356-768-6",printIsbn:"978-1-80356-767-9",pdfIsbn:"978-1-80356-769-3",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!1,isSalesforceBook:!1,isNomenclature:!1,hash:"a654d23b4e684207c0c5fb8793b5cb6b",bookSignature:"Dr. Kian Chung Ong",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11827.jpg",keywords:"Risk Factors, Epidemiology, Symptoms, Airway Dysfunction, Inflammation, Asthma, Lung Volume Reduction, Steroids, Non-invasive Ventilation, Health Geography, Sociology, Interdisciplinary",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"March 25th 2022",dateEndSecondStepPublish:"June 3rd 2022",dateEndThirdStepPublish:"August 2nd 2022",dateEndFourthStepPublish:"October 21st 2022",dateEndFifthStepPublish:"December 20th 2022",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"2 months",secondStepPassed:!0,areRegistrationsClosed:!0,currentStepOfPublishingProcess:4,editedByType:null,kuFlag:!1,biosketch:"A pioneering pulmonologist in pulmonary rehabilitation, exercise testing, non-invasive ventilation, hospital-at-home programs, with a keen interest in developing new modalities in disease management. Member of Academy of Medicine (Singapore), Royal College of Physicians (UK), American College of Chest Physicians.",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"103585",title:"Dr.",name:"Kian Chung",middleName:null,surname:"Ong",slug:"kian-chung-ong",fullName:"Kian Chung Ong",profilePictureURL:"https://mts.intechopen.com/storage/users/103585/images/system/103585.jpeg",biography:"Dr. Ong is a respiratory physician and intensivist of twenty-five years' experience. He is currently the medical director of Chestmed Pte Ltd, Mount Elizabeth Medical Centre, Singapore. He is also the founding and current president of the Chronic Obstructive Pulmonary Disease Association (Singapore) and is a member of the Global Initiative for Chronic Obstructive Lung Disease (GOLD) Assembly. He is the principal author of multiple publications in international peer-reviewed medical journals such as CHEST, European Respiratory Journal, American Journal of Respiratory and Critical Care Medicine, and Respiratory Medicine. He is also the editor of several textbooks: Chronic Obstructive Pulmonary Disease – Current Concepts and Practice, Lung Inflammation, Chronic Obstructive Pulmonary Disease - a Current Conspectus.",institutionString:"Mount Elizabeth Medical Centre",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"3",institution:{name:"Mount Elizabeth Hospital",institutionURL:null,country:{name:"Singapore"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"16",title:"Medicine",slug:"medicine"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"453624",firstName:"Martina",lastName:"Scerbe",middleName:null,title:"Ms.",imageUrl:"https://mts.intechopen.com/storage/users/453624/images/20399_n.jpg",email:"martina.s@intechopen.com",biography:null}},relatedBooks:[{type:"book",id:"648",title:"Chronic Obstructive Pulmonary Disease",subtitle:"Current Concepts and Practice",isOpenForSubmission:!1,hash:"d52ddc19c473a70b91e5a64f41760a04",slug:"chronic-obstructive-pulmonary-disease-current-concepts-and-practice",bookSignature:"Kian-Chung Ong",coverURL:"https://cdn.intechopen.com/books/images_new/648.jpg",editedByType:"Edited by",editors:[{id:"103585",title:"Dr.",name:"Kian Chung",surname:"Ong",slug:"kian-chung-ong",fullName:"Kian Chung Ong"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3843",title:"Lung Inflammation",subtitle:null,isOpenForSubmission:!1,hash:"92938e8752fa3444849d88b776cd7892",slug:"lung-inflammation",bookSignature:"Kian Chung Ong",coverURL:"https://cdn.intechopen.com/books/images_new/3843.jpg",editedByType:"Edited by",editors:[{id:"103585",title:"Dr.",name:"Kian Chung",surname:"Ong",slug:"kian-chung-ong",fullName:"Kian Chung Ong"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10330",title:"Chronic Obstructive Pulmonary Disease",subtitle:"A Current Conspectus",isOpenForSubmission:!1,hash:"ed4471e26a96efbcc23ba3683ad5ea69",slug:"chronic-obstructive-pulmonary-disease-a-current-conspectus",bookSignature:"Kian Chung Ong",coverURL:"https://cdn.intechopen.com/books/images_new/10330.jpg",editedByType:"Edited by",editors:[{id:"103585",title:"Dr.",name:"Kian Chung",surname:"Ong",slug:"kian-chung-ong",fullName:"Kian Chung Ong"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6550",title:"Cohort Studies in Health Sciences",subtitle:null,isOpenForSubmission:!1,hash:"01df5aba4fff1a84b37a2fdafa809660",slug:"cohort-studies-in-health-sciences",bookSignature:"R. 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Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"67246",title:"Social Isolation Experienced by Youth in Social Withdrawal: Toward an Interdisciplinary Analysis and Practice",doi:"10.5772/intechopen.86503",slug:"social-isolation-experienced-by-youth-in-social-withdrawal-toward-an-interdisciplinary-analysis-and-",body:'\nSocial isolation experienced by young people refers to a state in which social interactions with others are limited or even absent for a long period of time. This can take place as a result of involuntary circumstances such as school bullying, peer exclusion, hospitalization, institutionalization, or absence/incarceration of family members or alternatively by voluntary social withdrawal from interacting with others to avoid bullying, frustration, social anxiety, or stress [1, 2]. In the discipline of developmental psychology, involuntary social withdrawal is considered equivalent to social isolation or school disaffection suffered by children and adolescents particularly in educational settings, who are characterized by apparent shyness, asocialness, unsociability, aloneness, and peer avoidance [3]. Social isolation resulted from peer exclusion may not necessarily lead to a sense of loneliness particularly when young people feel that some intimate others and adult mentors are still around to listen and help. However, when the quantity of interpersonal network is limited and the quality of social support is inadequate, socially withdrawn children and adolescents are more at risk of failing to develop appropriate social and interpersonal skills for engaging in positive interaction with peers in school or community settings. When objective social isolation is further perpetuated as a consequence of involuntary peer exclusion or voluntary social withdrawal as the last resort to react against unfavorable circumstances beyond one’s control, loneliness understood as a subjective experience or as “perceived social isolation” would take place [4, 5].
\nUnlike those student counterparts experiencing a state of social isolation and a sense of loneliness who are usually the targets of study in developmental psychology/psychopathology, this chapter focuses on discussing social isolation experienced by young people in social withdrawal as atomistic individuals, who seclude at home and lead a hermetic way of life without making face-to-face social contacts or having social relationships and interactions with the world other than their family members for a protracted period of time [5, 6]. Young people experiencing social isolation in the form of social withdrawal are characterized by their socially avoidant behavior and their invisibility from the care of helping professionals and the scrutiny of the public [7, 8], who are labeled as “hikikomori” (i.e., young hermits) in Japan [9] and as “hidden youth” in Hong Kong [10]. Young people who seclude themselves at home are asocial in behavioral and relational terms and thus silently trapped in the state of asocialness without enjoying much emotional and instrumental support. However, in the case of young people who are having a psychiatric problem, physical illness, or disability, which has prevented them from participating in the community, they would not be considered as “pure” or “primary” social withdrawal cases. They are instead regarded as secondary social withdrawal cases as a consequence of primary psychiatric or physical problems [11]. In other words, social withdrawal is not primarily a mental health or disability problem, but an anomic behavioral response to difficulties encountered by young people [12]. However, it is entirely possible for primary social withdrawal cases to develop symptoms of depression or social anxiety if they are left alone and feel alone at home for an incredibly long period of time without receiving any professional service.
\nThis chapter first defines social withdrawal experienced by youth with reference to four parameters so as to highlight the nature of social isolation confronted by these young people who are turned invisible, voiceless, and disengaged. Informed by the principle of “starting where the client is,” we then discuss different forms of in-home and community-based social work intervention targeted to self-secluded young people who are socially isolated from others other than their family. By using the empirical data drawn from a longitudinal study of youth with social withdrawal experience at home, the next session addresses the importance of interdisciplinary research and practice which is deemed important to facilitate young people to regain a sense of agency and a sense of expectancy for overcoming social isolation and its alienating relational and health outcomes. Before drawing a conclusion, we highlight the importance of advocacy work and its relationship with interdisciplinary research and practice.
\nThe first two are the interlocking parameters of time and place; the third one is the lack of face-to-face contacts and interactions other than family members; and the final one is the deprivation of a legitimate social status [4].
\nAccording to the Japanese government, social withdrawal or
Most of the youth respondents were happy with their secluded lives in the first few months as they could take a break without being interfered, play online games, surf the Internet, and do many other things they were fond of doing. Nevertheless, dispensing with social relationships with others for a long time has deskilled young people in the sense that it leads them to forget how to engage in normal interactions and relationships with others and, accordingly, heightens their anxiety to venture into the community [5, 8]. As shown in research studies in Japan,
An extended absence of a variety of face-to-face contacts and interactions at home and beyond the home boundary is likely to lead to the deskilling of young people in relation to intimate others such as parents, siblings, and friends and outsiders such as neighbors and strangers. The longer the period of social withdrawal, the higher the likelihood young people will find it difficult to read facial expressions, respond to causal greetings, and engage in causal chats, which in turn results in a downward spiral or vicious cycle of social isolation. Being confined at home without interacting with people face to face does not preclude the possibility of young people’s interaction with previous close friends and “virtual others” on the Internet platform. They may have online chatting with peers and ex-classmates on an occasional basis particularly in the beginning phase of self-isolation. But they would likely stop doing so when their ex-peers’ pacing and environment of life have become so different from theirs. Self-secluded individuals at home may chat with online players even though without knowing them personally. Virtual online interaction may be interpreted as a manifestation of their desire to make contact with the outside world. This kind of “virtual chatting,” however, is not conducive to developing trustful relationship particularly in view of the lack of offline interaction and companionship [5].
\nUnlike their student counterparts suffering from social isolation in school settings, young people in social withdrawal at home do not lead a life with a social status as a student, worker, or trainee. They are instead labeled as NEET youth who are socially excluded from the institution of education, employment, or training. After staying for a long while without resuming study at school, going out to find a job in the labor market, or learning something useful in nearby community center, conflicts with their parents and siblings will take place. The conflict taking place on the same generation and across generations in the family context is usually focused on achieving a legitimate youth status as a student, worker, or trainee just like their normal youth counterparts. However, the concern of the family is different from that of the focal person who is too anxious and frightened to map out their transition to a socially legitimate social status. The following verbatim quotes from the first author’s field data are representative of clients’ reactions against practitioners or outsiders’ intrusions into their safe “cocoon” [6]:
\nAs for the school worker, since he works in the school, he must speak for the school. So I did not want to talk to him. And the other one […] I did not know where he came from […] he did not look like a social worker. He looked like a construction worker […] I was very scared and ran into my room. At last, he talked to my mom instead of talking to me, saying something that I did not want to hear at all. I just hope that he will never come to disturb me again. (Sam, a client with social withdrawal experience)
\nI did not know where they had come from. I just thought they must be the allies of my parents. I can still remember that woman just asked me to stop surfing the internet and listen to her bullshit […] Another woman just told me “[I] would make my mom unhappy and disappointed if [I] kept on staying at home” […] She did not attempt to listen to me or understand my worries. (Peter, a client with social withdrawal experience)
\nWhat is obvious is that making a transition from the state of NEET to that of engagement in education, employment, or training will be a long rugged journey characterized by ups and downs. Unlike their NEET counterparts with antisocial behavior, self-secluded and socially isolated home hermits are characterized by their asocial, non-prosocial, and socially avoidant behavior. NEET is just an umbrella term which covers a wide spectrum of youth behaviors, ranging from antisocial to asocial. Many of these NEET youth just look like normal youth with sociable and prosocial behavior with the only exception of whether making a successful transition to work or study.
\nHowever, without enjoying a socially legitimate social status as a student, worker, or trainee, it does not mean that these self-secluded and finally socially isolated youth at home are not engaged in activities at all. Many of them were surfing information related to heritage and ecology preservation, leading an eco-friendly life at home, helping out household chores to reduce the care burden of their mother, and developing interest on their own by ongoing googling and/or practice at home, e.g., photo-taking, pet care, handicraft, production of eco-friendly stuff for domestic use, etc. [5, 6, 7, 8]. The next session discusses in what way these home-based activities undertaken by secluded youth are taken as interaction points for rapport building and intervention in a space the latter feel secure.
\nThe perpetuation of social isolation is not only personal but also structural. If social isolation of youth with chronic social withdrawal experience is to be overcome, social inclusion with concerted efforts made on personal, interpersonal, and structural levels have to be made. Viewed from a social exclusion perspective, the purpose of antisocial exclusion policy and measures paving for the way for social inclusion is to address two interrelated dimensions: exclusion from work and exclusion from social relations [18]. To take a step further, Walker and Walker further argue that social exclusion should be understood “as a dynamic process of being shut out, fully or partially, from any of the social, economic, political or cultural systems which determine the social integration of a person in society” [19]. That is, the structural causes of various forms of social exclusion or disengagement experienced by disadvantaged youth have to be thoroughly addressed even though each of their unique strengths, interests, experiences, and dreams, which are embedded into their transition stories, has to be taken into account.
\nFollowing aforementioned discussion, professional interventions designed for facilitating youth transition to the world of study, work, or training for those who have been trapped in alienating circumstances of self-seclusion and social isolation in a tiny home space for so long should not be taken as the goal of intervention in the beginning phase. Instead, what matters most in the initial stage of intervention is to build up rapport or initial trust with involuntary, vulnerable, secluded clients who are resistant to visitors and strangers. In the case of outreaching young hermits, the social work motto “to start where the client is” can be read in a literal sense of taking home as a secure place for initial interaction and intervention. Home-based intervention is more than home visitations, and it involves activities with a modest level of conversations or dialogue [20]. Before doing any home visiting, it is considered strategic to listen to the concern of the family and the client’s mother in particular who was usually the one to seek for help from social workers. At the meantime, helping professionals such as social workers, counselors, or youth workers have to seek relevant information about the client, e.g., personal particulars, length of self-seclusion at home, daily routines or activities, personal interest, relationship with family members, etc.
\nAccording to the practice wisdom of experienced social workers, it took on average nine contacts for building up an initial working relationship with each youth client, including but not restricted to home visiting, celebrating client’s birthday or doing festival celebration at home, presenting a small gift with the name of the client on it, telephone chatting, leaving behind a handwritten note for Internet or mobile phone contact, texting by using text messaging apps, etc. [5, 6, 7, 8]. In the first few home visitations, social workers usually go in pair, as the primary social worker was to initiate interaction with or minimal conversations with the client on something he or she felt interested about, and the other worker was to talk with other family members outside the home environment particularly when they were moralizing the issue or blaming their child. The underlying principle is to start where the client is, which is understood in two interlocking senses: the first of which is to talk about something different from the family’s primary concern or about the previous traumatic experience of the client; and the second is to be sensitive to the home environment in terms of both statics and dynamics of which the former refers to family photos, pictures, toys, books, magazines, gifts, souvenirs, etc., whereas the latter refers to family conversations and interactions, activities, or interests that the client was engaged in such as cooking, making desserts, taking care of a pet or two, cleaning goldfish tanks, taking photos of the street, playing online game, etc. Acknowledging the skills and knowledge involved in undertaking all these interest activities or daily routines can open up a space for engaging secluded youth in social interaction and minimal conversations that they have not experienced for so long.
\nIn a home setting, the artifacts available for providing clues to possible talking points include family ornaments, souvenirs, furniture, and so on. In case of difficulties to engage in direct conversation with clients because of their resistance to visitors, it was through talking about artifacts or pictures in the living room that the parents, usually the mothers, were able to elicit happy memories with their beloved children in relation to their unique strengths and abilities. As most of the cases of the first authors’ studies were of working class background, their living space was tiny, and the partitioned walls in the clients’ homes were not a barrier to their overhearing conversations taking place in the living room. The explicit absence of clients, hidden away from any interaction with social workers as strangers, did not rule out their implicit presence in hearing what is said positive about them. This could help youth clients recall the previous harmonious relationship with their family. These conversations provide a contrast with more recent and current stories filled with frustration, conflict, and anger. This indirect intervention approach can at least help build up an initial working relationship with clients’ family and may arouse clients’ curiosity about the friendly attitude of helping professionals.
\nStarting where the clients are does not mean ending up where they are. After gaining initial trust with the worker, the client could be invited to initiate some ideas that they would like to pursue at home, for example, learn to develop one’s interest at home in the presence of the worker perhaps with the company and instruction from a youth mentor or try out some new interest that they could not afford to do or dare to dream of doing so, e.g., learn to play magic, keyboard, drum, or guitar, use recycled materials for handicraft making, or even do home-based volunteering or simple paid job by designing a poster for promoting an agency’s program targeted to others in need [5]. In this sense, secluded youth at home could develop a sense of agency and a sense of contribution which are all good for rebuilding their self-esteem.
\nAnother innovative means to build initial rapport at clients’ homes is to work with animal-assisted therapists or practitioners to use a therapy dog for doing home visitations and interactions. In accordance to the verbatim drawn from a study of the first author, a social worker working with youth in social withdrawal made a related remark as follows:
\nThe dog is called “Fat Fat,” which is a tiny dog. Fat Fat is very nice and friendly…Tiny dogs are more acceptable for home visitations, as security guards usually turned a blind eye to this. It’s harder if we use therapy dogs of a bigger size...Fat Fat was shortsighted, and he was used to smell and greet others at close distance. Whenever he smelt the presence of young people at proximity, the latter would feel less on guard…. (Adrian, a social worker).
\nAffective relations with pet or therapeutic animals go beyond the conventional understanding of human relations [21]. The interaction process with the therapy dog Fat Fat opened up the space for dialogues between clients and social workers. The clients were less defensive to relate to social workers as visitors, since the focus of conversation was around the therapy dog rather than taking clients as the focus of concern. The use of therapeutic dogs is not only effective for icebreaking and building trust and rapport with social workers but also affective by giving youth clients a sense of warmth and a sense of touch that they had not experienced with their family members and any others outside the home for so long.
\nAs to youth with extended self-seclusion experience, anywhere beyond the home environment is a groan zone where they find it risky and uncomfortable. The longer these isolated young people stay at home without making any face-to-face contacts and interactions with others in the community, the more difficult they will find it to make a move outside their comfort zone. One of the effective ways to give these young people an incentive to destabilize their sense of “homeboundedness” is for their entrusted social worker to accompany them to do an unfinished task or two they aspired to settle. The needs and tasks may be as simple as fixing a computer, enjoying a trip to the countryside, having a haircut, buying something in nearby commercial arcade, seeing some heritage buildings, taking photos of beautiful flowers, etc. Acknowledging clients’ intention to do or settle something beyond their home environment, though seemingly minute to the rest of the world, can serve as a starting point for making a breakthrough against home confinement, spatially and mentally. Social workers can make use of this opportunity to facilitate homebound youth to plan ahead, make decision, and do mental rehearsal for the tasks they would like to pursue with the company and support from social workers. The experience of venturing into the community can provide secluded youth a solid base for driving out their fear and anxiety for meeting strangers outside their home environment and reflecting on the experience for drawing learnings that could be applied for the next outing.
\nNGOs with a drop-in corner or activity rooms can provide homebound youth an ideal setting to learn new things of interest to them, as the service environment has given tangible resources and mentoring support that are conducive to rebuilding the trust of homebound youth to outsiders. That is, the focus is placed on interest-based learning for satisfying their learning needs and resuming normal social interactions with others rather than on seeking formal educational or vocational qualifications which were too demanding to them. Another advantage of giving young people with social withdrawal experience a variety of choices of one-off events or short-term courses with just a few sessions is to give them a chance to make decision on their own, try out new things without making any commitment, and make new friends who may have the same interests or the same background of having self-seclusion and social isolation experience. In an environment that is relatively free of name-calling, teasing, and testing out behaviors, and in an environment where people are more sympathetic and supportive to each other, young people with shyness or social phobia are more able to develop sociable and prosocial behaviors for exploring and experimenting informal relationships in the real world. This reminds social workers the importance of working with youth clients in a professional yet informal manner which can provide them a secure place for appreciating and building informal and faithful peer relations that will last much longer than formal worker-client relationship [5].
\nIn another career intervention program supervised by the first author, young people with seclusion experience were invited to visit shelter dogs which had abused or abandoned experience before and engaged in human-canine activities designed to promote a positive relationship between humans and animals. Narrative review is used to help youth participants explore the values, attitudes, skills, and knowledge involved in caring for sheltered dogs and find meaning in life. Young people reported that a reciprocal relationship was experienced in the process of caring for the dogs, which offered trust, acceptance, unconditional love, and nonjudgmental contact. The youth participants offered love, care, companionship, and a secure interacting environment for the dogs, which encouraged them to believe in their ability to care for living beings. A positive self-identity with a greater sense of achievement and self-worth was built up. The interaction was also beneficial to the dogs as they became trusting, confident, and accepting of human care. Such a positive response from the dogs further reinforced a sense of contribution among the youth participants. Many of them were inspired to explore animal care work and to promote animal welfare. The program also supported young people to become mentors, to share their transformations with new members of the program and with parents, teachers, and other community stakeholders. And through the provision of workplace learning and mentoring opportunities, they were facilitated to explore about the possibility of continuing doing volunteering in animal care and animal rights and developing a vocational career related to animal care or pet care industries. In a career and life adventure planning project funded by the Hong Kong Jockey Club Charities Trust which is the number one donor in Hong Kong, the experience to date shows that when young people such as those with chronic social withdrawal experience are provided an enabling environment with resources, opportunities, and networks, they can archive, reflect, and develop their own set of transferable values, attitudes, skills, and knowledge across different domains of paid and unpaid work experiences [22] and define their own meaningful career roadmap; they can and will make positive contributions toward a better and more inclusive world [23].
\nIn a brand-new interdisciplinary study conducted by a team of academics and researchers of the background of nursing and social work professions in Hong Kong, a total of 104 youth clients with social withdrawal experience were invited to participate in a research study as respondents by means of completing a set of questionnaires and going through some anthropometric and physical measurements. Measurements were taken by a well-trained nursing student, which include body weight, height, length and width of ears, blood pressure, pulse rate, respiratory rate, and waist and hip circumference which were recorded and used for calculating the body mass index and waist-hip ratio. This interdisciplinary study across nursing and social work professions is the first ever study studying the physical health aspects of
This group of youth respondents living with a
This positive change in terms of health actions taken by the respondents could be related to two episodes of experiences. First, the respondents were informed by the nursing researcher the measures in an archived format immediately after the physical assessment, which could trigger their health awareness and their eagerness to take actions to make improvements for the next round of follow-up assessments 6 and 12 months after. Second, although social workers are not health professionals by themselves, they can use the archived record as a talking point and remind their clients to lead a healthy lifestyle by doing more exercises and developing healthier diet habits. That is, taking actions for making improvement with health and physical measures to impress oneself and others over time is considered conducive to creating a sense of expectancy among the respondents. The practice of using archived records for talking and reminder purpose consistent with the health belief model which emphasizes beholders’ awareness of threat perception (risk) and positive initiatives (opportunity) is the key to trigger appropriate actions for realizing positive health outcomes [26, 27]. This implies that promoting interdisciplinary collaboration across healthcare and social care disciplines is not only good for breeding new ideas for conducting research studies but also for producing health measures in the form of visible archive for engaging secluded youth to develop a sense of expectancy and a sense of agency for making improvements with their lifestyle and health outcomes.
\nAs viewed from the nursing perspective, the focus is placed on providing care using a holistic approach and with interdisciplinary collaboration to ensure the best possible outcome for the client. Nursing care models and the “nursing process” help guide and organize how care is provided to clients. As demonstrated in the aforementioned interdisciplinary study of youth living a
In cooperation with other healthcare professionals, nursing interventions offer access to empirical health data as well as clients’ specimens for a better understanding of the pathophysiology. Biomedical scientists look into the potential biomarkers for making accurate diagnosis and to explain the pathological pathways, in order to allow for effective medical treatments. Recently, based on the assumption of avoidant personality disorder as the most common comorbidity of
Socially withdrawn youth suffering from social isolation have not been able to receive regular targeted funding support from the Social Welfare Department (SWD) which is responsible for allocating and administering the bulk of government-funded social welfare services in Hong Kong, whether in statutory, governmental, or NGO settings. On many different occasions, SWD bureaucrats just replied that integrated youth service teams are capable of outreaching secluded youth in the community. These integrated teams are established to provide a wide range of services including children and youth center services, school social work services, and outreaching youth work under one management to meet the multifarious needs of children and youth aged 6–24. However, as these homebound cases are very much demanding of time and effort, and the integrated teams are under pressure to deliver sufficient service output to satisfy the Funding and Service Agreement requirements of the SWD, this invisible group of atomistic individuals would be subject to the risk of receiving inadequate attention and services from integrated teams. Wong argued that government inaction on this specific “hidden problem” which does not upset the community like their street counterparts with antisocial behavior has resulted in ironing out the diversity and differences of NEET youth [6], thus reproducing the inverse care law: availability of services tends to vary inversely with the need of the population served [30]. Advocating for a concerted social policy and more financial and manpower resources to set up separate teams all over Hong Kong to outreach young people in social withdrawal can prevent extended social isolation and consequential poor physical and mental health outcomes from taking place. With the consolidation of practice wisdom and evidence-based practice developed on interdisciplinary collaboration platforms with input from a diversity of health and social care professionals such as social workers, teachers, nurses, doctors, animal-assisted therapists, physiotherapists, physical exercise experts, etc., and with resources, opportunities, and networks by means of engaging multiple stakeholders including employers, parents, and mentors, youth with chronic social withdrawal and social isolation experience can be facilitated to make a transition into the community as a student, trainee, or worker in the conventional sense or as a lifelong learner eager to be engaged in paid and unpaid work experiences and other life-wide experiences in order to map out their career pathway with life’s deep meanings.
\nAll this does not rule out the possibility that with the support of solid research work and studies, social workers and youth work practitioners can share their practice wisdom and evidence-based practices with their professional counterparts working in school, center-wise, and other community-based settings. And it is entirely possible for different professional parties to work in a collaborative manner to involve multiple stakeholders including employers to provide seamless provision of services ranging from a variety of home-based interventions to a plurality of initiatives and measures including interest development, workplace learning, and other on-the-job and corporate mentoring programs.
\nSocial isolation experienced by young people in the form of extended or chronic social withdrawal at home for a protracted period of time is characterized by its invisibility and inaccessibility to adequate social provisions. For each single and unique case of youth with social withdrawal experience, helping professionals have to address the temporal, spatial, relational, and status-wise parameters in a comprehensive manner in order to map out the context and direction of professional intervention.
\nHowever, self-seclusion with resulted stagnation in transition to a legitimate social status does not imply any clientele inactivity at home. Starting where the clients are is to stay tuned with their current interest, routines, and activities they do at home, which can provide the basis for interaction, rapport building, and modest level of conversations. This can help scaffold their further interest- and activity-based learning at home and pave the way for pursuing beyond home learning and fulfilling unfinished tasks in the community.
\nIndividual young people have to learn to interact with others, kick off learning momentum, develop a healthy diet, do exercises, step out their alienating comfort zone, reengage with the community, try out workplace learning, map out their career roadmap, and make contributions to others and the community, but it will not be effective if they are confronted with blaming-the-victim discourses and circumstances unfavorable for realizing their abilities, strengths, and aspirations. Examples of such circumstances include the inadequacy of structural and institutional support; the lack of institutional, organizational, and professional flexibility; the lack of social networks and social capital; the lack of cross-sectoral and interdisciplinary collaboration; and the lack of the provision of an enabling environment where young people can enjoy access to resources, opportunities, and networks for reflecting and developing transferable values, attitudes, skills, and knowledge across different life domains.
\nGiving young people an enabling environment by means of engaging the participation and involvement of multiple stakeholders for the sake of enhancing youth’s agency, esteem and expectancy can nourish their hopes and raise their aspirations. Again, it is important to seek research funding support to conduct empirical interdisciplinary research studies that could address both the personal and the structural aspects of social withdrawal and social isolation and deliver an analysis of problems and interventions. The causes of social isolation of young people in the form of extended social withdrawal at home are both personal and structural, and thus the conceptualization and delivery of viable measures and interventions have to address both personal and structural dimensions [5, 31]. Interdisciplinary collaboration in terms of practice and research is expected to play a growing important role to do advocacy along this line in the journey ahead.
\nThe empirical findings were drawn from a number of research projects supported by the following funding bodies: the Health and Medical Research Fund (Project No. 13144071) from the Food and Health Bureau of Hong Kong, the General Research Fund (Project No. GRF/244707) from the Research Grants Council of Hong Kong, the Faculty Research Grant (Project No. FRG/05-06/I-01-30-05-101) from Hong Kong Baptist University, and the Trust-Initiated Project Fund (Project No. HKBU/HKJCCT-33-14-211) from the Hong Kong Jockey Club Charities Trust.
\nThe authors declare no conflict of interest.
Classification of pituitary adenomas is still changing; it requires morphological and hormonal immunohistochemical assessments. These adenomas reveal various histopathological patterns and tinctorial properties which proved to be unreliable and do not always correlate with the functional or immunohistochemical findings.
The 3rd WHO classification of adenohypophyseal cell lineage in pituitary adenomas in 2004 was based on functional properties using histological study, immunohistochemical properties, ultrastructural features, biochemical imaging, and surgical findings [1].
The 4th WHO classification of pituitary adenomas in 2017 [2] is mostly based on the adenohypophyseal cell lineage designation according to immunohistochemical markers such as pituitary hormones and pituitary-specific transcription factors. Comparison between the 3rd and the 4th WHO classification is shown in Table 1.
The 3rd WHO classification of pituitary adenomas [1] | The 4th WHO classification of pituitary adenomas [3] |
---|---|
Growth hormone producing adenoma | Somatotroph adenoma |
Prolactin producing adenoma | Lactotroph adenoma |
Thyrotropin producing adenoma | Thyrotroph adenoma |
ACTH producing adenoma | Corticotroph adenoma |
Gonadotropin producing adenoma | Gonadotroph adenoma |
Null cell adenoma | Null cell adenoma |
Plurihormonal adenoma | Plurihormonal and double adenoma |
Comparison between the 3rd and the 4th WHO classification of pituitary adenomas.
Some transcription factors and cofactors have a known role in the differentiation of pituitary cell lineages [2, 3, 4], e.g., PIT1 (pituitary transcription factor 1 for growth hormone also known as POUF1 [3]), ER-alpha (nuclear estrogen receptor alpha), SF1 (splicing factor 1), and TPIT (transcription factor for pituitary corticotroph cell lineage).
Many adenomas secrete one hormone; though secretion of more than one hormone is well documented, the following combinations of hormones are reported [1, 3]:
GH (growth hormone) and PRL (prolactin)
FSH and LH
FSH, LH, TSH, and a-SU (alpha subunit is identical for gonadotropin hormones and TSH)
Tumor cells in these cases are originating from the same cell lineage.
Immunostaining is achieving a progressively important role in pituitary adenomas. The 4th WHO classification of pituitary adenomas in 2017 [2] is mostly based on the adenohypophyseal cell lineage designation according to immunohistochemical markers for the main secreting hormones; for example, the new designation “somatotroph adenoma” defines a group of tumors that are derived from a PIT1 lineage and secrete growth hormone; this replaces the former term growth hormone-producing adenoma as previously designed in the 3rd WHO classification [1].
Immunohistochemical markers allow for differentiation between clinically relevant histological subtypes that was mainly ultrastructural features. Electron microscopy is now rarely used to classify pituitary tumors; it is not necessary for the routine investigation of pituitary tumors. However, ultrastructural evaluation may be useful in the differential diagnosis of undifferentiated tumors and in a very limited number of adenoma subtypes, such as plurihormonal PIT1-positive adenoma [2].
Transcription factors for pituitary cell lineages are as follows [3, 4]:
Somatotroph lineage: PIT1, which is a pituitary transcription factor 1 for growth hormone also known as POUF1.
Lactotroph differentiation: PIT1 and ER-alpha.
Thyrotroph differentiation: PIT1 and GATA2. GATA2 is a nuclear protein regulating gene expression.
Gonadotroph differentiation: GATA2 and SF1. SF1 is splicing factor 1, also known as zinc finger protein 162.
Corticotroph cell lineage: TPIT.
Plurihormonal pituitary adenomas are defined as tumors that show immunoreactivity for more than one hormone that cannot be explained by normal cytophysiology or developmental mechanism [5]. They can be monomorphous, consisting of a single cell type producing two or more hormones, or plurimorphous, consisting of two or more different cell lineages.
Plurihormonality is reported in the literature; it is estimated rare in most studied series while they are more frequent in other series [5, 6, 7, 8]. Most plurihormonal adenomas are silent [2]. Various combinations are described in the literature in the studied series:
PRL and LH; PRL and TSH [7]
ACTH, LH, and TSH [7]
PRL, LH, FSH, and TSH [7]
GH, PRL, TSH, and a-SU [5]
GH, PRL, TSH, FSH, and aSU [15]
Other less common combinations are also published [5]. Original examples of plurihormonal adenomas in the author series [7] are shown in Figures 1–3.
(A) Pituitary adenoma revealing a trabecular and nested structure (HE stain, x200), composed of two distinct types of cells. (B) ACTH secretion in the same adenoma (x400, ACTH-antibody, Dako). (C) Prolactin secretion in the same adenoma (x400, PRL-antibody, Dako). Positive stain is demonstrated in different cells than cells positive for ACTH. Detection of other pituitary hormones was negative.
(A) Pituitary adenoma revealing a pseudoglandular and microcystic structure (x400, HE stain). (B). Prolactin secretion in some tumor cells (x400, PRL-antibody, Dako). (C) TSH secretion in the same tumor, apparently in different cells than prolactin secretion (x400, TSH-antibody, Dako). (D) FSH secretion in the same tumor, apparently in different cells than prolactin and TSH secretion (x400, FSH-antibody, Dako).
(A) Crooke cell adenoma (x400, HE stain). (B) ACTH secretion in the same Crooke cell adenoma (x400, ACTH-antibody, Dako). (C). Prolactin secretion in the same crook cell adenoma, apparently positive in the same cells as ACTH (x400, PRL-antibody, Dako). Detection of other pituitary hormones was negative.
Some of the secretions might remain subclinical and only detected by immunohistochemical studies.
It was noted that half of the somatotroph adenomas, particularly densely granulated adenomas, secrete other hormones; these hormones are not clinically relevant [1, 3].
A combination of hormone secretion was also reported in double pituitary adenoma base on two separate tumors on MRI imaging or histopathologic examination [5].
Pituitary adenomas with the combination of different hormone groups from the same cell lineage (GH and prolactin or FSH and LH) are relatively common, but true plurihormonal adenomas with immunoreactivities that cross the cytogenetic lineage are rare in most series as “in Refs. [5, 6, 13].”
The challenging points are:
How many cells that are positive for each type of hormones or pituitary transcription factors can allow the diagnosis of plurihormonal adenoma?
The new definition of the null cell adenoma requires the demonstration of immunonegativity for pituitary transcription factors and adenohypophyseal hormones [2, 16]; however, does the observation of rare or few positive cells for immunohistochemical markers allow to rule out the diagnosis of null cell adenoma?
Many studies tried to find out the criteria for predicting the prognosis and development of pituitary adenomas; though most of them have benign outcomes, others might have adverse outcomes and be able to invade locally, resist conventional therapy, or might recur or metastasize [2].
The following question is raised: Is any relationships exist between hormone secretion and prognosis of pituitary adenomas?
Certain subtypes of pituitary adenomas are found tending to show more aggressive clinical behavior and designed by some authors as aggressive adenomas [2]; these are: sparsely granulated somatotroph adenoma (SGSA), lactotroph macroadenoma in men, Crooke cell adenoma, silent corticotroph adenoma, and plurihormonal PIT1-positive adenoma (previously called silent subtype 3 adenomas [1, 2, 3, 5]). It is also reported that pituitary adenomas found in MEN1 (multiple endocrine neoplasia type 1) tend to be plurihormonal and more aggressive [12].
The defined criteria for this adenoma in the last 4th WHO classification for pituitary adenomas are, as “in Refs. [2, 3, 17]”:
Rapid growth
Radiological invasion
High Ki-67 proliferation index more than 3%
This adenoma tends to predict recurrence and resistance to conventional therapy [2].
It is not clear whether all potentially “aggressive pituitary adenomas” are “high-risk adenomas,” as the first term depends on hormone secretion, while the second term depends on clinical and radiological data plus the immunohistochemical study for Ki-67 proliferation index. P53 is not considered as an independent risk factor [2].
A high risk adenoma with histological signs of aggressiveness is shown in Figure 4.
Aggressive and high-risk pituitary adenoma revealing vascular invasion and mitotic figures (x200, HE stain). It demonstrated immunonegativity for hormone secretion.
The term “atypical adenoma” was previously used in the 3rd WHO classification [1]; it is defined by a high mitotic index, Ki-67 mitotic index more than 3%, and strong nuclear P53 staining. This term is no more used in the 4th classification [2], as it did not prove any utility. Atypical adenoma is replaced by the definition of “high-risk adenoma.” Strong positive nuclear expression of P53 is not proved to be an independent factor of high-risk adenoma [2].
Plurihormonal PIT1-positive adenomas are aggressive in terms of their size, growth rate, and invasiveness, with cavernous sinus invasion occurring in 67% of cases and 31% rate of recurrence [5].
The only conclusive criterion of malignancy is actually metastasis. The last WHO classification of pituitary adenomas strictly defined pituitary carcinoma as a tumor of adenohypophyseal cells that metastasizes craniospinally or is associated with systemic metastasis. This definition is independent of the histological appearance; as histologically, about 60% of primary tumors have features of a conventional adenoma [2, 18].
Pre-metastatic lesions and metastases can be hormonally active or clinically nonfunctioning. There are no clinical or biochemical features specific to an adenoma that will metastasize [18]. No confirmed relationship is demonstrated between non-secreting adenoma, plurihormonality, and malignancy; though, plurihormonal PIT1-positive carcinomas have also been reported [18].
This term is recently proposed in 2017 for pituitary adenoma by the International Pituitary Pathology Club to explain the highly variable clinical impact of pituitary adenomas on patients and the poor reproducibility of the actual predictive markers [19] though the margins are not clear between pituitary adenomas and neuroendocrine tumors.
Pituitary carcinomas are demonstrated positive for neuroendocrine differentiation like synaptophysin and chromogranin A [18].
Pathologists and clinicians might ask the following questions:
Is it necessary to make histological study to every pituitary adenoma?
Is it necessary to demonstrate hormonal production in all pituitary adenomas studied by pathologists?
How many antibodies should a pathologist use to study this adenoma?
Which antibodies have clinical utility for treatment and prognostic prediction?
Can we predict the aggressiveness of a pituitary adenoma before that it becomes clinically and radiologically aggressive?
We might find answers on the previous questions in the following findings:
Classification of pituitary adenomas requires morphological and hormonal immunohistochemical assessment [2, 3].
Nonfunctional adenomas, with no hormone detection in the serum, are not necessarily nonproducing adenomas. Detection of hormonal production by immunostaining leads to term them “silent adenomas” [2, 3]. Some authors recently proposed to term them “poorly differentiated Pit-1 lineage adenomas” [20].
Immunostaining is important to diagnose some of the potentially “aggressive adenomas” subtypes as mentioned before.
Detection of PIT1 and hormonal production is important for the diagnosis of plurihormonal PIT1-positive pituitary adenomas (previously called silent subtype 3 adenomas) that are considered as potentially “aggressive adenoma” [2, 5].
Detection of the somatostatin receptor by immunohistochemistry may be a useful predictor of treatment response, as SGSAs are less responsive to somatostatin antagonists and may require treatment with the GH receptor antagonist pegvisomant [21].
Demonstration of immunonegativity for hormones and transcription factors, especially Pit-1, is important for the differential diagnosis between silent adenomas and null cell adenoma, as the latter has good prognosis. Some silent adenomas, notably silent corticotroph adenoma and plurihormonal PIT1-positive adenoma (previously called silent subtype 3 adenomas), are considered potentially “aggressive adenomas” [2, 17, 22].
Demonstration of NSE, chromogranin A and synaptophysin helps to diagnose PitNET and might predict more aggressive potential even before that the tumor comes clinically and radiologically aggressive.
It is important to demonstrate hormone production, transcription factors for functional differentiation, and proliferation index that indicate prediction. Practically, the following immunohistochemical stains are recommended in studying a pituitary adenoma as they cover wide area of diagnosis and prediction:
GH, prolactin, TSH-beta, ACTH, FSH-beta, LH-beta, and alpha-SU to make an accurate classification of the studied pituitary adenoma.
Pit-1 and TPIT transcription factors and ER-alpha are recommended when there is immunonegativity for pituitary hormones, to rule out potentially aggressive silent adenomas. SF1, the transcription factor for gonadotroph cell lineage does not seem to have prognostic importance, as gonadotroph adenomas are usually not aggressive.
Ki-67 proliferation index, for the demonstration of “high-risk adenomas.”
Chromogranin A and synaptophysin diagnose PitNET that might predict more aggressive behavior.
P53 is not an independent risk factor of aggressiveness; so it is not necessary to demonstrate it.
Immunohistochemical studies have increasing importance in pituitary adenomas. Demonstration of hormones, some transcription factors and cofactors for functional differentiation, and proliferation index have important roles in the classification, prediction, and treatment of these adenomas, as demonstration of neuroendocrine differentiation.
I declare that there is no “conflict of interest” in this chapter.
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\n\nAfter we receive your proof corrections and a final typeset of the manuscript is approved, your manuscript is sent to our in house DTP department for technical formatting and online publication preparation.
\n\nAdditionally, you will be asked to provide a profile picture (face or chest-up portrait photograph) and a short summary of the book which is required for the book cover design.
\n\n6. INVOICE PAYMENT
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For this, the development of human resources should be emphasized and a suitable atmosphere should be prepared for this widespread prosperity.",book:{id:"5819",slug:"research-and-development-evolving-trends-and-practices-towards-human-institutional-and-economic-sectors-growth",title:"Research and Development Evolving Trends and Practices",fullTitle:"Research and Development Evolving Trends and Practices - Towards Human, Institutional and Economic Sectors Growth"},signatures:"Orhan Özçatalbaş",authors:[{id:"170206",title:"Prof.",name:"Dr. Orhan",middleName:null,surname:"Özçatalbaş",slug:"dr.-orhan-ozcatalbas",fullName:"Dr. Orhan Özçatalbaş"}]},{id:"66110",doi:"10.5772/intechopen.84770",title:"Gold Recovery Process from Primary and Secondary Resources Using Bioadsorbents",slug:"gold-recovery-process-from-primary-and-secondary-resources-using-bioadsorbents",totalDownloads:2038,totalCrossrefCites:2,totalDimensionsCites:3,abstract:"Bioadsorbents were prepared in a simple manner only by treating in boiling concentrated sulfuric acid from various biomass materials such as various polysaccharides, persimmon tannin, cotton, paper and biomass wastes such as orange juice residue and microalgae residue after extracting biofuel. These bioadsorbents exhibited high selectivity only to gold over other metals and extraordinary high loading capacity for gold(III), which were elucidated to be attributable to the selective reduction of gold(III) ion to elemental gold due to its highest oxidation-reduction potential of gold(III) of metal ions, catalyzed by the surface of bioadsorbents prepared in boiling sulfuric acid. By using these biosorbents, recovery of gold from actual samples of printed circuit boards of spent mobile phones and Mongolian gold ore was investigated. Recovery of trace concentration of gold(I) from simulated spent alkaline cyanide solution was also investigated using the bioadsorbent. Application of bioadsorbents to some recovery processes of gold from cyanide solutions was proposed.",book:{id:"8150",slug:"elements-of-bioeconomy",title:"Elements of Bioeconomy",fullTitle:"Elements of Bioeconomy"},signatures:"Katsutoshi Inoue, Durga Parajuli, Manju Gurung, Bimala Pangeni, Kanjana Khunathai, Keisuke Ohto and Hidetaka Kawakita",authors:[{id:"198951",title:"Prof.",name:"Keisuke",middleName:null,surname:"Ohto",slug:"keisuke-ohto",fullName:"Keisuke Ohto"},{id:"259238",title:"Dr.",name:"Hidetaka",middleName:null,surname:"Kawakita",slug:"hidetaka-kawakita",fullName:"Hidetaka Kawakita"},{id:"289372",title:"Dr.",name:"Katsutoshi",middleName:null,surname:"Inoue",slug:"katsutoshi-inoue",fullName:"Katsutoshi Inoue"},{id:"298633",title:"Dr.",name:"Bimala",middleName:null,surname:"Pangeni",slug:"bimala-pangeni",fullName:"Bimala Pangeni"},{id:"298634",title:"Dr.",name:"Manju",middleName:null,surname:"Gurung",slug:"manju-gurung",fullName:"Manju Gurung"},{id:"298635",title:"Dr.",name:"Kanjana",middleName:null,surname:"Khunathai",slug:"kanjana-khunathai",fullName:"Kanjana Khunathai"},{id:"298636",title:"Dr.",name:"Durga",middleName:null,surname:"Parajuli",slug:"durga-parajuli",fullName:"Durga Parajuli"}]},{id:"66428",doi:"10.5772/intechopen.84833",title:"Review of Biofuel Technologies in WtL and WtE",slug:"review-of-biofuel-technologies-in-wtl-and-wte",totalDownloads:1216,totalCrossrefCites:1,totalDimensionsCites:3,abstract:"Processing of biomass feedstocks to produce energy, fuels, and chemicals via a combination of different applied technologies is considered a promising pathway to achieve sustainable waste management, with many environmental and economic benefits. In this chapter, we review the current state of the main processes associated with energy recovery and biofuel production under the concept of waste biorefineries. The reviewed technologies are classified into thermochemical, biological, and chemical, including combustion, gasification, steam explosion, pyrolysis, hydrothermal liquefaction, and torrefaction; anaerobic digestion, fermentation, enzymatic treatment, and microbial electrolysis; and hydrolysis, solvent extraction, transesterification, and supercritical conversion. Their brief history, current status, and future developments are discussed within a perspective of valorization and managing of current waste streams with no solution.",book:{id:"8150",slug:"elements-of-bioeconomy",title:"Elements of Bioeconomy",fullTitle:"Elements of Bioeconomy"},signatures:"Bruno B. Garcia, Gonçalo Lourinho, Paulo Brito and Pedro Romano",authors:[{id:"261653",title:"Prof.",name:"Paulo",middleName:null,surname:"Brito",slug:"paulo-brito",fullName:"Paulo Brito"},{id:"261654",title:"Prof.",name:"Pedro",middleName:null,surname:"Romano",slug:"pedro-romano",fullName:"Pedro Romano"},{id:"291751",title:"B.Sc.",name:"Bruno B.",middleName:"B",surname:"Garcia",slug:"bruno-b.-garcia",fullName:"Bruno B. Garcia"},{id:"291752",title:"MSc.",name:"Gonçalo",middleName:null,surname:"Lourinho",slug:"goncalo-lourinho",fullName:"Gonçalo Lourinho"}]},{id:"65966",doi:"10.5772/intechopen.84664",title:"Life Cycle Assessment as a Tool to Implement Sustainable Development in the Bioeconomy and Circular Economy",slug:"life-cycle-assessment-as-a-tool-to-implement-sustainable-development-in-the-bioeconomy-and-circular-",totalDownloads:1334,totalCrossrefCites:0,totalDimensionsCites:2,abstract:"In this chapter, the life cycle assessment was presented as a tool to implement sustainable development in the bioeconomy and circular economy. Bulky waste includes large items such as furniture, doors, flooring and mattresses. The management of bulky waste is a serious problem for European countries. The URBANREC project proposed a solution to this problem through the use of new technologies for the bulky waste processing. The aim of the URBANREC project is to implement an eco-innovative, integrated system of bulky waste management and demonstrate its effectiveness in various regions of Europe. The project has received funding from the European Union. In this chapter, the LCA environmental analysis was performed for the technology of grinding bulky waste using a water jet by the Ecofrag company. The calculations were carried out using SimaPro 8.5.2.0. The LCA analysis shows that the reuse of foams and mattresses contributes to the avoidance of their targeted production, which is related with the reduction of greenhouse gas emission and consumption of fossil raw materials.",book:{id:"8150",slug:"elements-of-bioeconomy",title:"Elements of Bioeconomy",fullTitle:"Elements of Bioeconomy"},signatures:"Izabela Samson-Bręk, Marta Gabryszewska, Justyna Wrzosek and Barbara Gworek",authors:[{id:"281239",title:"Dr.",name:"Izabela",middleName:null,surname:"Samson-Brek",slug:"izabela-samson-brek",fullName:"Izabela Samson-Brek"},{id:"290299",title:"Mrs.",name:"Marta",middleName:null,surname:"Gabryszewska",slug:"marta-gabryszewska",fullName:"Marta Gabryszewska"},{id:"290300",title:"Dr.",name:"Justyna",middleName:null,surname:"Wrzosek",slug:"justyna-wrzosek",fullName:"Justyna Wrzosek"},{id:"290301",title:"Prof.",name:"Barbara",middleName:null,surname:"Gworek",slug:"barbara-gworek",fullName:"Barbara Gworek"}]}],mostDownloadedChaptersLast30Days:[{id:"66110",title:"Gold Recovery Process from Primary and Secondary Resources Using Bioadsorbents",slug:"gold-recovery-process-from-primary-and-secondary-resources-using-bioadsorbents",totalDownloads:2038,totalCrossrefCites:2,totalDimensionsCites:3,abstract:"Bioadsorbents were prepared in a simple manner only by treating in boiling concentrated sulfuric acid from various biomass materials such as various polysaccharides, persimmon tannin, cotton, paper and biomass wastes such as orange juice residue and microalgae residue after extracting biofuel. These bioadsorbents exhibited high selectivity only to gold over other metals and extraordinary high loading capacity for gold(III), which were elucidated to be attributable to the selective reduction of gold(III) ion to elemental gold due to its highest oxidation-reduction potential of gold(III) of metal ions, catalyzed by the surface of bioadsorbents prepared in boiling sulfuric acid. By using these biosorbents, recovery of gold from actual samples of printed circuit boards of spent mobile phones and Mongolian gold ore was investigated. Recovery of trace concentration of gold(I) from simulated spent alkaline cyanide solution was also investigated using the bioadsorbent. Application of bioadsorbents to some recovery processes of gold from cyanide solutions was proposed.",book:{id:"8150",slug:"elements-of-bioeconomy",title:"Elements of Bioeconomy",fullTitle:"Elements of Bioeconomy"},signatures:"Katsutoshi Inoue, Durga Parajuli, Manju Gurung, Bimala Pangeni, Kanjana Khunathai, Keisuke Ohto and Hidetaka Kawakita",authors:[{id:"198951",title:"Prof.",name:"Keisuke",middleName:null,surname:"Ohto",slug:"keisuke-ohto",fullName:"Keisuke Ohto"},{id:"259238",title:"Dr.",name:"Hidetaka",middleName:null,surname:"Kawakita",slug:"hidetaka-kawakita",fullName:"Hidetaka Kawakita"},{id:"289372",title:"Dr.",name:"Katsutoshi",middleName:null,surname:"Inoue",slug:"katsutoshi-inoue",fullName:"Katsutoshi Inoue"},{id:"298633",title:"Dr.",name:"Bimala",middleName:null,surname:"Pangeni",slug:"bimala-pangeni",fullName:"Bimala Pangeni"},{id:"298634",title:"Dr.",name:"Manju",middleName:null,surname:"Gurung",slug:"manju-gurung",fullName:"Manju Gurung"},{id:"298635",title:"Dr.",name:"Kanjana",middleName:null,surname:"Khunathai",slug:"kanjana-khunathai",fullName:"Kanjana Khunathai"},{id:"298636",title:"Dr.",name:"Durga",middleName:null,surname:"Parajuli",slug:"durga-parajuli",fullName:"Durga Parajuli"}]},{id:"56708",title:"Human Development and Research-Development-Extension Relationships",slug:"human-development-and-research-development-extension-relationships",totalDownloads:1775,totalCrossrefCites:1,totalDimensionsCites:5,abstract:"Human capital is the most important strategic factor for development; as new technologies emerge, the market demand for better and healthier products and consumer demand in terms of quality and delivery time are changing. In today’s world, it becomes increasingly important to know how information can be accessed, how it is adopted, and how it can be assimilated. In this respect, each country allocates budget for training, education, and extension according to its own conditions. This budget may be intended for rural community-based social assistance, but the economic and welfare effect is essential. In this way, it is aimed to increase the living standards of the families living in the rural areas. This will naturally contribute to national income and to the prosperity of society. The subject has been discussed generally in the world, especially in the case of Turkey. According to this, all over the world, particularly in developing countries, research and extension (R&E) is very important and should be considered at least as much as research and development (R&D). However, it will be ensured that societies meet with the technology produced. For this, the development of human resources should be emphasized and a suitable atmosphere should be prepared for this widespread prosperity.",book:{id:"5819",slug:"research-and-development-evolving-trends-and-practices-towards-human-institutional-and-economic-sectors-growth",title:"Research and Development Evolving Trends and Practices",fullTitle:"Research and Development Evolving Trends and Practices - Towards Human, Institutional and Economic Sectors Growth"},signatures:"Orhan Özçatalbaş",authors:[{id:"170206",title:"Prof.",name:"Dr. Orhan",middleName:null,surname:"Özçatalbaş",slug:"dr.-orhan-ozcatalbas",fullName:"Dr. Orhan Özçatalbaş"}]},{id:"68851",title:"Introductory Chapter: Objectives and Scope of Bioeconomy",slug:"introductory-chapter-objectives-and-scope-of-bioeconomy",totalDownloads:996,totalCrossrefCites:0,totalDimensionsCites:0,abstract:null,book:{id:"8150",slug:"elements-of-bioeconomy",title:"Elements of Bioeconomy",fullTitle:"Elements of Bioeconomy"},signatures:"Krzysztof Biernat",authors:[{id:"155009",title:"Prof.",name:"Krzysztof",middleName:null,surname:"Biernat",slug:"krzysztof-biernat",fullName:"Krzysztof Biernat"}]},{id:"68007",title:"Overview of the Process of Enzymatic Transformation of Biomass",slug:"overview-of-the-process-of-enzymatic-transformation-of-biomass",totalDownloads:1412,totalCrossrefCites:4,totalDimensionsCites:5,abstract:"Cellulase is an enzyme which depolymerizes the cellulose into glucose. Cellulases are produced by a diverse array of microbes including fungi, bacteria, yeast and actinomycetes. Considerable research for understanding the mechanism of cellulases began in early 1950s because of the significant use of these enzymes in various industries. This review provides a general account structure and availability of lignocellulosic biomass, pretreatment strategies for effective digestion, cellulase producing organisms, cellulase activity assay, and enzymology of cellulose degradation. Cellulase production, optimization, purification and characterization studies in addition to the industrial application of cellulase have also been discussed. At last a brief account of present market scenario of cellulases and future prospects of the study are also taken into account.",book:{id:"8150",slug:"elements-of-bioeconomy",title:"Elements of Bioeconomy",fullTitle:"Elements of Bioeconomy"},signatures:"Namita Singh, Anita Devi, Manju Bala Bishnoi, Rajneesh Jaryal, Avni Dahiya, Oleksandr Tashyrev and Vira Hovorukha",authors:[{id:"278205",title:"Prof.",name:"Namita",middleName:null,surname:"Singh",slug:"namita-singh",fullName:"Namita Singh"},{id:"282352",title:"Dr.",name:"Anita",middleName:null,surname:"Devi",slug:"anita-devi",fullName:"Anita Devi"},{id:"282353",title:"MSc.",name:"Avni",middleName:null,surname:"Dahiya",slug:"avni-dahiya",fullName:"Avni Dahiya"},{id:"282354",title:"MSc.",name:"Manju Bala",middleName:null,surname:"Bishnoi",slug:"manju-bala-bishnoi",fullName:"Manju Bala Bishnoi"},{id:"282355",title:"Dr.",name:"Oleksandr",middleName:null,surname:"Tashyrev",slug:"oleksandr-tashyrev",fullName:"Oleksandr Tashyrev"},{id:"282356",title:"Dr.",name:"Rajneesh",middleName:null,surname:"Jaryal",slug:"rajneesh-jaryal",fullName:"Rajneesh Jaryal"},{id:"282939",title:"Dr.",name:"Vira",middleName:null,surname:"Hovorukha",slug:"vira-hovorukha",fullName:"Vira Hovorukha"}]},{id:"67691",title:"The Use of Waste Management Techniques to Enhance Household Income and Reduce Urban Water Pollution",slug:"the-use-of-waste-management-techniques-to-enhance-household-income-and-reduce-urban-water-pollution",totalDownloads:1044,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"Appropriate waste management options are major concerns in the developing world. Current methods include incineration in the open and accumulation of wastes in designated places where they constitute nuisance to the environment. Apart from air pollution from the incinerators, leachates from decomposed wastes are either washed off where they serve as source of pollutants to the adjourning streams and rivers or contaminate groundwater through deep percolation. We present viable options for managing agricultural wastes in this chapter. The options presented are so simple and sustainable such that it can be managed by individuals. Hence, they are independent of the government bureaucratic bottlenecks that have been the bane of the previous government interventions. If embraced, it will also serve as sources of income for the concerned household, hence enhance their livelihood.",book:{id:"8150",slug:"elements-of-bioeconomy",title:"Elements of Bioeconomy",fullTitle:"Elements of Bioeconomy"},signatures:"Olayiwola A. Akintola, Olufunmilayo O. Idowu, Suraju A. Lateef, Gbenga A. Adebayo, Adekemi O. Shokalu and Omolara I. Akinyoola",authors:[{id:"293178",title:"Dr.",name:"Olayiwola A.",middleName:null,surname:"Akintola",slug:"olayiwola-a.-akintola",fullName:"Olayiwola A. Akintola"},{id:"297217",title:"Dr.",name:"Olufunmilayo O.",middleName:null,surname:"Idowu",slug:"olufunmilayo-o.-idowu",fullName:"Olufunmilayo O. Idowu"},{id:"297218",title:"Dr.",name:"Suraju A.",middleName:null,surname:"Lateef",slug:"suraju-a.-lateef",fullName:"Suraju A. Lateef"},{id:"297219",title:"Dr.",name:"Gbenga A.",middleName:null,surname:"Adebayo",slug:"gbenga-a.-adebayo",fullName:"Gbenga A. Adebayo"},{id:"297221",title:"Dr.",name:"Adekemi O.",middleName:null,surname:"Shokalu",slug:"adekemi-o.-shokalu",fullName:"Adekemi O. Shokalu"},{id:"297222",title:"Mrs.",name:"Omolara I.",middleName:null,surname:"Akinyoola",slug:"omolara-i.-akinyoola",fullName:"Omolara I. Akinyoola"}]}],onlineFirstChaptersFilter:{topicId:"455",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:108,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:141,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:124,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:22,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:12,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"13",title:"Veterinary Medicine and Science",doi:"10.5772/intechopen.73681",issn:"2632-0517",scope:"Paralleling similar advances in the medical field, astounding advances occurred in Veterinary Medicine and Science in recent decades. These advances have helped foster better support for animal health, more humane animal production, and a better understanding of the physiology of endangered species to improve the assisted reproductive technologies or the pathogenesis of certain diseases, where animals can be used as models for human diseases (like cancer, degenerative diseases or fertility), and even as a guarantee of public health. Bridging Human, Animal, and Environmental health, the holistic and integrative “One Health” concept intimately associates the developments within those fields, projecting its advancements into practice. This book series aims to tackle various animal-related medicine and sciences fields, providing thematic volumes consisting of high-quality significant research directed to researchers and postgraduates. It aims to give us a glimpse into the new accomplishments in the Veterinary Medicine and Science field. By addressing hot topics in veterinary sciences, we aim to gather authoritative texts within each issue of this series, providing in-depth overviews and analysis for graduates, academics, and practitioners and foreseeing a deeper understanding of the subject. Forthcoming texts, written and edited by experienced researchers from both industry and academia, will also discuss scientific challenges faced today in Veterinary Medicine and Science. In brief, we hope that books in this series will provide accessible references for those interested or working in this field and encourage learning in a range of different topics.",coverUrl:"https://cdn.intechopen.com/series/covers/13.jpg",latestPublicationDate:"August 7th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:11,editor:{id:"38652",title:"Prof.",name:"Rita",middleName:null,surname:"Payan-Carreira",slug:"rita-payan-carreira",fullName:"Rita Payan-Carreira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRiFPQA0/Profile_Picture_1614601496313",biography:"Rita Payan Carreira earned her Veterinary Degree from the Faculty of Veterinary Medicine in Lisbon, Portugal, in 1985. She obtained her Ph.D. in Veterinary Sciences from the University of Trás-os-Montes e Alto Douro, Portugal. After almost 32 years of teaching at the University of Trás-os-Montes and Alto Douro, she recently moved to the University of Évora, Department of Veterinary Medicine, where she teaches in the field of Animal Reproduction and Clinics. Her primary research areas include the molecular markers of the endometrial cycle and the embryo–maternal interaction, including oxidative stress and the reproductive physiology and disorders of sexual development, besides the molecular determinants of male and female fertility. She often supervises students preparing their master's or doctoral theses. She is also a frequent referee for various journals.",institutionString:null,institution:{name:"University of Évora",institutionURL:null,country:{name:"Portugal"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:3,paginationItems:[{id:"19",title:"Animal Science",coverUrl:"https://cdn.intechopen.com/series_topics/covers/19.jpg",isOpenForSubmission:!0,editor:{id:"259298",title:"Dr.",name:"Edward",middleName:null,surname:"Narayan",slug:"edward-narayan",fullName:"Edward Narayan",profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",biography:"Dr. Edward Narayan graduated with Ph.D. degree in Biology from the University of the South Pacific and pioneered non-invasive reproductive and stress endocrinology tools for amphibians - the novel development and validation of non-invasive enzyme immunoassays for the evaluation of reproductive hormonal cycle and stress hormone responses to environmental stressors. \nDr. Narayan leads the Stress Lab (Comparative Physiology and Endocrinology) at the University of Queensland. A dynamic career research platform which is based on the thematic areas of comparative vertebrate physiology, stress endocrinology, reproductive endocrinology, animal health and welfare, and conservation biology. \nEdward has supervised 40 research students and published over 60 peer reviewed research.",institutionString:null,institution:{name:"University of Queensland",institutionURL:null,country:{name:"Australia"}}},editorTwo:null,editorThree:null},{id:"20",title:"Animal Nutrition",coverUrl:"https://cdn.intechopen.com/series_topics/covers/20.jpg",isOpenForSubmission:!0,editor:{id:"175967",title:"Dr.",name:"Manuel",middleName:null,surname:"Gonzalez Ronquillo",slug:"manuel-gonzalez-ronquillo",fullName:"Manuel Gonzalez Ronquillo",profilePictureURL:"https://mts.intechopen.com/storage/users/175967/images/system/175967.png",biography:"Dr. Manuel González Ronquillo obtained his doctorate degree from the University of Zaragoza, Spain, in 2001. He is a research professor at the Faculty of Veterinary Medicine and Animal Husbandry, Autonomous University of the State of Mexico. He is also a level-2 researcher. He received a Fulbright-Garcia Robles fellowship for a postdoctoral stay at the US Dairy Forage Research Center, Madison, Wisconsin, USA in 2008–2009. He received grants from Alianza del Pacifico for a stay at the University of Magallanes, Chile, in 2014, and from Consejo Nacional de Ciencia y Tecnología (CONACyT) to work in the Food and Agriculture Organization’s Animal Production and Health Division (AGA), Rome, Italy, in 2014–2015. He has collaborated with researchers from different countries and published ninety-eight journal articles. 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Singh",profilePictureURL:"https://mts.intechopen.com/storage/users/329385/images/system/329385.png",institutionString:"Punjab Technical University",institution:{name:"Punjab Technical University",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8018",title:"Extracellular Matrix",subtitle:"Developments and Therapeutics",coverURL:"https://cdn.intechopen.com/books/images_new/8018.jpg",slug:"extracellular-matrix-developments-and-therapeutics",publishedDate:"October 27th 2021",editedByType:"Edited by",bookSignature:"Rama Sashank Madhurapantula, Joseph Orgel P.R.O. and Zvi Loewy",hash:"c85e82851e80b40282ff9be99ddf2046",volumeInSeries:23,fullTitle:"Extracellular Matrix - Developments and Therapeutics",editors:[{id:"212416",title:"Dr.",name:"Rama Sashank",middleName:null,surname:"Madhurapantula",slug:"rama-sashank-madhurapantula",fullName:"Rama Sashank Madhurapantula",profilePictureURL:"https://mts.intechopen.com/storage/users/212416/images/system/212416.jpg",institutionString:"Illinois Institute of Technology",institution:{name:"Illinois Institute of Technology",institutionURL:null,country:{name:"United States of America"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Proteomics",value:18,count:4},{group:"subseries",caption:"Metabolism",value:17,count:6},{group:"subseries",caption:"Cell and Molecular Biology",value:14,count:9},{group:"subseries",caption:"Chemical Biology",value:15,count:14}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:9},{group:"publicationYear",caption:"2021",value:2021,count:7},{group:"publicationYear",caption:"2020",value:2020,count:12},{group:"publicationYear",caption:"2019",value:2019,count:3},{group:"publicationYear",caption:"2018",value:2018,count:2}],authors:{paginationCount:148,paginationItems:[{id:"165328",title:"Dr.",name:"Vahid",middleName:null,surname:"Asadpour",slug:"vahid-asadpour",fullName:"Vahid Asadpour",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/165328/images/system/165328.jpg",biography:"Vahid Asadpour, MS, Ph.D., is currently with the Department of Research and Evaluation, Kaiser Permanente Southern California. He has both an MS and Ph.D. in Biomedical Engineering. He was previously a research scientist at the University of California Los Angeles (UCLA) and visiting professor and researcher at the University of North Dakota. He is currently working in artificial intelligence and its applications in medical signal processing. In addition, he is using digital signal processing in medical imaging and speech processing. Dr. Asadpour has developed brain-computer interfacing algorithms and has published books, book chapters, and several journal and conference papers in this field and other areas of intelligent signal processing. He has also designed medical devices, including a laser Doppler monitoring system.",institutionString:"Kaiser Permanente Southern California",institution:null},{id:"169608",title:"Prof.",name:"Marian",middleName:null,surname:"Găiceanu",slug:"marian-gaiceanu",fullName:"Marian Găiceanu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/169608/images/system/169608.png",biography:"Prof. Dr. Marian Gaiceanu graduated from the Naval and Electrical Engineering Faculty, Dunarea de Jos University of Galati, Romania, in 1997. He received a Ph.D. (Magna Cum Laude) in Electrical Engineering in 2002. Since 2017, Dr. Gaiceanu has been a Ph.D. supervisor for students in Electrical Engineering. He has been employed at Dunarea de Jos University of Galati since 1996, where he is currently a professor. Dr. Gaiceanu is a member of the National Council for Attesting Titles, Diplomas and Certificates, an expert of the Executive Agency for Higher Education, Research Funding, and a member of the Senate of the Dunarea de Jos University of Galati. He has been the head of the Integrated Energy Conversion Systems and Advanced Control of Complex Processes Research Center, Romania, since 2016. He has conducted several projects in power converter systems for electrical drives, power quality, PEM and SOFC fuel cell power converters for utilities, electric vehicles, and marine applications with the Department of Regulation and Control, SIEI S.pA. (2002–2004) and the Polytechnic University of Turin, Italy (2002–2004, 2006–2007). He is a member of the Institute of Electrical and Electronics Engineers (IEEE) and cofounder-member of the IEEE Power Electronics Romanian Chapter. He is a guest editor at Energies and an academic book editor for IntechOpen. He is also a member of the editorial boards of the Journal of Electrical Engineering, Electronics, Control and Computer Science and Sustainability. Dr. Gaiceanu has been General Chairman of the IEEE International Symposium on Electrical and Electronics Engineering in the last six editions.",institutionString:'"Dunarea de Jos" University of Galati',institution:{name:'"Dunarea de Jos" University of Galati',country:{name:"Romania"}}},{id:"4519",title:"Prof.",name:"Jaydip",middleName:null,surname:"Sen",slug:"jaydip-sen",fullName:"Jaydip Sen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/4519/images/system/4519.jpeg",biography:"Jaydip Sen is associated with Praxis Business School, Kolkata, India, as a professor in the Department of Data Science. His research areas include security and privacy issues in computing and communication, intrusion detection systems, machine learning, deep learning, and artificial intelligence in the financial domain. He has more than 200 publications in reputed international journals, refereed conference proceedings, and 20 book chapters in books published by internationally renowned publishing houses, such as Springer, CRC press, IGI Global, etc. Currently, he is serving on the editorial board of the prestigious journal Frontiers in Communications and Networks and in the technical program committees of a number of high-ranked international conferences organized by the IEEE, USA, and the ACM, USA. He has been listed among the top 2% of scientists in the world for the last three consecutive years, 2019 to 2021 as per studies conducted by the Stanford University, USA.",institutionString:"Praxis Business School",institution:null},{id:"320071",title:"Dr.",name:"Sidra",middleName:null,surname:"Mehtab",slug:"sidra-mehtab",fullName:"Sidra Mehtab",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00002v6KHoQAM/Profile_Picture_1584512086360",biography:"Sidra Mehtab has completed her BS with honors in Physics from Calcutta University, India in 2018. She has done MS in Data Science and Analytics from Maulana Abul Kalam Azad University of Technology (MAKAUT), Kolkata, India in 2020. Her research areas include Econometrics, Time Series Analysis, Machine Learning, Deep Learning, Artificial Intelligence, and Computer and Network Security with a particular focus on Cyber Security Analytics. Ms. Mehtab has published seven papers in international conferences and one of her papers has been accepted for publication in a reputable international journal. She has won the best paper awards in two prestigious international conferences – BAICONF 2019, and ICADCML 2021, organized in the Indian Institute of Management, Bangalore, India in December 2019, and SOA University, Bhubaneswar, India in January 2021. Besides, Ms. Mehtab has also published two book chapters in two books. Seven of her book chapters will be published in a volume shortly in 2021 by Cambridge Scholars’ Press, UK. Currently, she is working as the joint editor of two edited volumes on Time Series Analysis and Forecasting to be published in the first half of 2021 by an international house. Currently, she is working as a Data Scientist with an MNC in Delhi, India.",institutionString:"NSHM College of Management and Technology",institution:{name:"Association for Computing Machinery",country:{name:"United States of America"}}},{id:"226240",title:"Dr.",name:"Andri Irfan",middleName:null,surname:"Rifai",slug:"andri-irfan-rifai",fullName:"Andri Irfan Rifai",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/226240/images/7412_n.jpg",biography:"Andri IRFAN is a Senior Lecturer of Civil Engineering and Planning. He completed the PhD at the Universitas Indonesia & Universidade do Minho with Sandwich Program Scholarship from the Directorate General of Higher Education and LPDP scholarship. He has been teaching for more than 19 years and much active to applied his knowledge in the project construction in Indonesia. His research interest ranges from pavement management system to advanced data mining techniques for transportation engineering. He has published more than 50 papers in journals and 2 books.",institutionString:null,institution:{name:"Universitas Internasional Batam",country:{name:"Indonesia"}}},{id:"314576",title:"Dr.",name:"Ibai",middleName:null,surname:"Laña",slug:"ibai-lana",fullName:"Ibai Laña",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/314576/images/system/314576.jpg",biography:"Dr. Ibai Laña works at TECNALIA as a data analyst. He received his Ph.D. in Artificial Intelligence from the University of the Basque Country (UPV/EHU), Spain, in 2018. He is currently a senior researcher at TECNALIA. His research interests fall within the intersection of intelligent transportation systems, machine learning, traffic data analysis, and data science. He has dealt with urban traffic forecasting problems, applying machine learning models and evolutionary algorithms. He has experience in origin-destination matrix estimation or point of interest and trajectory detection. Working with large volumes of data has given him a good command of big data processing tools and NoSQL databases. He has also been a visiting scholar at the Knowledge Engineering and Discovery Research Institute, Auckland University of Technology.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"314575",title:"Dr.",name:"Jesus",middleName:null,surname:"L. Lobo",slug:"jesus-l.-lobo",fullName:"Jesus L. Lobo",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/314575/images/system/314575.png",biography:"Dr. Jesús López is currently based in Bilbao (Spain) working at TECNALIA as Artificial Intelligence Research Scientist. In most cases, a project idea or a new research line needs to be investigated to see if it is good enough to take into production or to focus on it. That is exactly what he does, diving into Machine Learning algorithms and technologies to help TECNALIA to decide whether something is great in theory or will actually impact on the product or processes of its projects. So, he is expert at framing experiments, developing hypotheses, and proving whether they’re true or not, in order to investigate fundamental problems with a longer time horizon. He is also able to design and develop PoCs and system prototypes in simulation. He has participated in several national and internacional R&D projects.\n\nAs another relevant part of his everyday research work, he usually publishes his findings in reputed scientific refereed journals and international conferences, occasionally acting as reviewer and Programme Commitee member. Concretely, since 2018 he has published 9 JCR (8 Q1) journal papers, 9 conference papers (e.g. ECML PKDD 2021), and he has co-edited a book. He is also active in popular science writing data science stories for reputed blogs (KDNuggets, TowardsDataScience, Naukas). Besides, he has recently embarked on mentoring programmes as mentor, and has also worked as data science trainer.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"103779",title:"Prof.",name:"Yalcin",middleName:null,surname:"Isler",slug:"yalcin-isler",fullName:"Yalcin Isler",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRyQ8QAK/Profile_Picture_1628834958734",biography:"Yalcin Isler (1971 - Burdur / Turkey) received the B.Sc. degree in the Department of Electrical and Electronics Engineering from Anadolu University, Eskisehir, Turkey, in 1993, the M.Sc. degree from the Department of Electronics and Communication Engineering, Suleyman Demirel University, Isparta, Turkey, in 1996, the Ph.D. degree from the Department of Electrical and Electronics Engineering, Dokuz Eylul University, Izmir, Turkey, in 2009, and the Competence of Associate Professorship from the Turkish Interuniversity Council in 2019.\n\nHe was Lecturer at Burdur Vocational School in Suleyman Demirel University (1993-2000, Burdur / Turkey), Software Engineer (2000-2002, Izmir / Turkey), Research Assistant in Bulent Ecevit University (2002-2003, Zonguldak / Turkey), Research Assistant in Dokuz Eylul University (2003-2010, Izmir / Turkey), Assistant Professor at the Department of Electrical and Electronics Engineering in Bulent Ecevit University (2010-2012, Zonguldak / Turkey), Assistant Professor at the Department of Biomedical Engineering in Izmir Katip Celebi University (2012-2019, Izmir / Turkey). He is an Associate Professor at the Department of Biomedical Engineering at Izmir Katip Celebi University, Izmir / Turkey, since 2019. In addition to academics, he has also founded Islerya Medical and Information Technologies Company, Izmir / Turkey, since 2017.\n\nHis main research interests cover biomedical signal processing, pattern recognition, medical device design, programming, and embedded systems. He has many scientific papers and participated in several projects in these study fields. He was an IEEE Student Member (2009-2011) and IEEE Member (2011-2014) and has been IEEE Senior Member since 2014.",institutionString:null,institution:{name:"Izmir Kâtip Çelebi University",country:{name:"Turkey"}}},{id:"339677",title:"Dr.",name:"Mrinmoy",middleName:null,surname:"Roy",slug:"mrinmoy-roy",fullName:"Mrinmoy Roy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/339677/images/16768_n.jpg",biography:"An accomplished Sales & Marketing professional with 12 years of cross-functional experience in well-known organisations such as CIPLA, LUPIN, GLENMARK, ASTRAZENECA across different segment of Sales & Marketing, International Business, Institutional Business, Product Management, Strategic Marketing of HIV, Oncology, Derma, Respiratory, Anti-Diabetic, Nutraceutical & Stomatological Product Portfolio and Generic as well as Chronic Critical Care Portfolio. A First Class MBA in International Business & Strategic Marketing, B.Pharm, D.Pharm, Google Certified Digital Marketing Professional. Qualified PhD Candidate in Operations and Management with special focus on Artificial Intelligence and Machine Learning adoption, analysis and use in Healthcare, Hospital & Pharma Domain. Seasoned with diverse therapy area of Pharmaceutical Sales & Marketing ranging from generating revenue through generating prescriptions, launching new products, and making them big brands with continuous strategy execution at the Physician and Patients level. Moved from Sales to Marketing and Business Development for 3.5 years in South East Asian Market operating from Manila, Philippines. Came back to India and handled and developed Brands such as Gluconorm, Lupisulin, Supracal, Absolut Woman, Hemozink, Fabiflu (For COVID 19), and many more. In my previous assignment I used to develop and execute strategies on Sales & Marketing, Commercialization & Business Development for Institution and Corporate Hospital Business portfolio of Oncology Therapy Area for AstraZeneca Pharma India Ltd. Being a Research Scholar and Student of ‘Operations Research & Management: Artificial Intelligence’ I published several pioneer research papers and book chapters on the same in Internationally reputed journals and Books indexed in Scopus, Springer and Ei Compendex, Google Scholar etc. Currently, I am launching PGDM Pharmaceutical Management Program in IIHMR Bangalore and spearheading the course curriculum and structure of the same. I am interested in Collaboration for Healthcare Innovation, Pharma AI Innovation, Future trend in Marketing and Management with incubation on Healthcare, Healthcare IT startups, AI-ML Modelling and Healthcare Algorithm based training module development. I am also an affiliated member of the Institute of Management Consultant of India, looking forward to Healthcare, Healthcare IT and Innovation, Pharma and Hospital Management Consulting works.",institutionString:null,institution:{name:"Lovely Professional University",country:{name:"India"}}},{id:"310576",title:"Prof.",name:"Erick Giovani",middleName:null,surname:"Sperandio Nascimento",slug:"erick-giovani-sperandio-nascimento",fullName:"Erick Giovani Sperandio Nascimento",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0033Y00002pDKxDQAW/ProfilePicture%202022-06-20%2019%3A57%3A24.788",biography:"Prof. Erick Sperandio is the Lead Researcher and professor of Artificial Intelligence (AI) at SENAI CIMATEC, Bahia, Brazil, also working with Computational Modeling (CM) and HPC. He holds a PhD in Environmental Engineering in the area of Atmospheric Computational Modeling, a Master in Informatics in the field of Computational Intelligence and Graduated in Computer Science from UFES. He currently coordinates, leads and participates in R&D projects in the areas of AI, computational modeling and supercomputing applied to different areas such as Oil and Gas, Health, Advanced Manufacturing, Renewable Energies and Atmospheric Sciences, advising undergraduate, master's and doctoral students. He is the Lead Researcher at SENAI CIMATEC's Reference Center on Artificial Intelligence. In addition, he is a Certified Instructor and University Ambassador of the NVIDIA Deep Learning Institute (DLI) in the areas of Deep Learning, Computer Vision, Natural Language Processing and Recommender Systems, and Principal Investigator of the NVIDIA/CIMATEC AI Joint Lab, the first in Latin America within the NVIDIA AI Technology Center (NVAITC) worldwide program. He also works as a researcher at the Supercomputing Center for Industrial Innovation (CS2i) and at the SENAI Institute of Innovation for Automation (ISI Automação), both from SENAI CIMATEC. He is a member and vice-coordinator of the Basic Board of Scientific-Technological Advice and Evaluation, in the area of Innovation, of the Foundation for Research Support of the State of Bahia (FAPESB). He serves as Technology Transfer Coordinator and one of the Principal Investigators at the National Applied Research Center in Artificial Intelligence (CPA-IA) of SENAI CIMATEC, focusing on Industry, being one of the six CPA-IA in Brazil approved by MCTI / FAPESP / CGI.br. He also participates as one of the representatives of Brazil in the BRICS Innovation Collaboration Working Group on HPC, ICT and AI. He is the coordinator of the Work Group of the Axis 5 - Workforce and Training - of the Brazilian Strategy for Artificial Intelligence (EBIA), and member of the MCTI/EMBRAPII AI Innovation Network Training Committee. He is the coordinator, by SENAI CIMATEC, of the Artificial Intelligence Reference Network of the State of Bahia (REDE BAH.IA). He leads the working group of experts representing Brazil in the Global Partnership on Artificial Intelligence (GPAI), on the theme \"AI and the Pandemic Response\".",institutionString:"Manufacturing and Technology Integrated Campus – SENAI CIMATEC",institution:null},{id:"1063",title:"Prof.",name:"Constantin",middleName:null,surname:"Volosencu",slug:"constantin-volosencu",fullName:"Constantin Volosencu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/1063/images/system/1063.png",biography:"Prof. Dr. Constantin Voloşencu graduated as an engineer from\nPolitehnica University of Timișoara, Romania, where he also\nobtained a doctorate degree. He is currently a full professor in\nthe Department of Automation and Applied Informatics at the\nsame university. Dr. Voloşencu is the author of ten books, seven\nbook chapters, and more than 160 papers published in journals\nand conference proceedings. He has also edited twelve books and\nhas twenty-seven patents to his name. He is a manager of research grants, editor in\nchief and member of international journal editorial boards, a former plenary speaker, a member of scientific committees, and chair at international conferences. His\nresearch is in the fields of control systems, control of electric drives, fuzzy control\nsystems, neural network applications, fault detection and diagnosis, sensor network\napplications, monitoring of distributed parameter systems, and power ultrasound\napplications. He has developed automation equipment for machine tools, spooling\nmachines, high-power ultrasound processes, and more.",institutionString:'"Politechnica" University Timişoara',institution:null},{id:"221364",title:"Dr.",name:"Eneko",middleName:null,surname:"Osaba",slug:"eneko-osaba",fullName:"Eneko Osaba",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/221364/images/system/221364.jpg",biography:"Dr. Eneko Osaba works at TECNALIA as a senior researcher. He obtained his Ph.D. in Artificial Intelligence in 2015. He has participated in more than twenty-five local and European research projects, and in the publication of more than 130 papers. He has performed several stays at universities in the United Kingdom, Italy, and Malta. Dr. Osaba has served as a program committee member in more than forty international conferences and participated in organizing activities in more than ten international conferences. He is a member of the editorial board of the International Journal of Artificial Intelligence, Data in Brief, and Journal of Advanced Transportation. He is also a guest editor for the Journal of Computational Science, Neurocomputing, Swarm, and Evolutionary Computation and IEEE ITS Magazine.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"275829",title:"Dr.",name:"Esther",middleName:null,surname:"Villar-Rodriguez",slug:"esther-villar-rodriguez",fullName:"Esther Villar-Rodriguez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/275829/images/system/275829.jpg",biography:"Dr. Esther Villar obtained a Ph.D. in Information and Communication Technologies from the University of Alcalá, Spain, in 2015. She obtained a degree in Computer Science from the University of Deusto, Spain, in 2010, and an MSc in Computer Languages and Systems from the National University of Distance Education, Spain, in 2012. Her areas of interest and knowledge include natural language processing (NLP), detection of impersonation in social networks, semantic web, and machine learning. Dr. Esther Villar made several contributions at conferences and publishing in various journals in those fields. Currently, she is working within the OPTIMA (Optimization Modeling & Analytics) business of TECNALIA’s ICT Division as a data scientist in projects related to the prediction and optimization of management and industrial processes (resource planning, energy efficiency, etc).",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"49813",title:"Dr.",name:"Javier",middleName:null,surname:"Del Ser",slug:"javier-del-ser",fullName:"Javier Del Ser",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49813/images/system/49813.png",biography:"Prof. Dr. Javier Del Ser received his first PhD in Telecommunication Engineering (Cum Laude) from the University of Navarra, Spain, in 2006, and a second PhD in Computational Intelligence (Summa Cum Laude) from the University of Alcala, Spain, in 2013. He is currently a principal researcher in data analytics and optimisation at TECNALIA (Spain), a visiting fellow at the Basque Center for Applied Mathematics (BCAM) and a part-time lecturer at the University of the Basque Country (UPV/EHU). His research interests gravitate on the use of descriptive, prescriptive and predictive algorithms for data mining and optimization in a diverse range of application fields such as Energy, Transport, Telecommunications, Health and Industry, among others. In these fields he has published more than 240 articles, co-supervised 8 Ph.D. theses, edited 6 books, coauthored 7 patents and participated/led more than 40 research projects. He is a Senior Member of the IEEE, and a recipient of the Biscay Talent prize for his academic career.",institutionString:"Tecnalia Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"278948",title:"Dr.",name:"Carlos Pedro",middleName:null,surname:"Gonçalves",slug:"carlos-pedro-goncalves",fullName:"Carlos Pedro Gonçalves",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRcmyQAC/Profile_Picture_1564224512145",biography:'Carlos Pedro Gonçalves (PhD) is an Associate Professor at Lusophone University of Humanities and Technologies and a researcher on Complexity Sciences, Quantum Technologies, Artificial Intelligence, Strategic Studies, Studies in Intelligence and Security, FinTech and Financial Risk Modeling. He is also a progammer with programming experience in:\n\nA) Quantum Computing using Qiskit Python module and IBM Quantum Experience Platform, with software developed on the simulation of Quantum Artificial Neural Networks and Quantum Cybersecurity;\n\nB) Artificial Intelligence and Machine learning programming in Python;\n\nC) Artificial Intelligence, Multiagent Systems Modeling and System Dynamics Modeling in Netlogo, with models developed in the areas of Chaos Theory, Econophysics, Artificial Intelligence, Classical and Quantum Complex Systems Science, with the Econophysics models having been cited worldwide and incorporated in PhD programs by different Universities.\n\nReceived an Arctic Code Vault Contributor status by GitHub, due to having developed open source software preserved in the \\"Arctic Code Vault\\" for future generations (https://archiveprogram.github.com/arctic-vault/), with the Strategy Analyzer A.I. module for decision making support (based on his PhD thesis, used in his Classes on Decision Making and in Strategic Intelligence Consulting Activities) and QNeural Python Quantum Neural Network simulator also preserved in the \\"Arctic Code Vault\\", for access to these software modules see: https://github.com/cpgoncalves. He is also a peer reviewer with outsanding review status from Elsevier journals, including Physica A, Neurocomputing and Engineering Applications of Artificial Intelligence. Science CV available at: https://www.cienciavitae.pt//pt/8E1C-A8B3-78C5 and ORCID: https://orcid.org/0000-0002-0298-3974',institutionString:"University of Lisbon",institution:{name:"Universidade Lusófona",country:{name:"Portugal"}}},{id:"241400",title:"Prof.",name:"Mohammed",middleName:null,surname:"Bsiss",slug:"mohammed-bsiss",fullName:"Mohammed Bsiss",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/241400/images/8062_n.jpg",biography:null,institutionString:null,institution:null},{id:"276128",title:"Dr.",name:"Hira",middleName:null,surname:"Fatima",slug:"hira-fatima",fullName:"Hira Fatima",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/276128/images/14420_n.jpg",biography:"Dr. Hira Fatima\nAssistant Professor\nDepartment of Mathematics\nInstitute of Applied Science\nMangalayatan University, Aligarh\nMobile: no : 8532041179\nhirafatima2014@gmal.com\n\nDr. Hira Fatima has received his Ph.D. degree in pure Mathematics from Aligarh Muslim University, Aligarh India. Currently working as an Assistant Professor in the Department of Mathematics, Institute of Applied Science, Mangalayatan University, Aligarh. She taught so many courses of Mathematics of UG and PG level. Her research Area of Expertise is Functional Analysis & Sequence Spaces. She has been working on Ideal Convergence of double sequence. She has published 17 research papers in National and International Journals including Cogent Mathematics, Filomat, Journal of Intelligent and Fuzzy Systems, Advances in Difference Equations, Journal of Mathematical Analysis, Journal of Mathematical & Computer Science etc. She has also reviewed few research papers for the and international journals. 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