The inner cellular network code techniques.
\r\n\tGlobalization does not represent a pure and generous process for humanity or other species, but rather it implies social exclusion and also provokes situations of vulnerability in groups of people, forced exclusion, and apartheid: poor job opportunities, lack of access to education, worse socio-sanitary conditions. Specifically, it can be said that social segregation entails the apartheid of social groups of different ages, genders, and ethnicities; these groups live a reality manifested through the deepening of poverty, in terms of increased vulnerability of the poor and groups with little economic, social, cultural, labor and health stability.
\r\n\r\n\tThis book aims to talk about some topics that are neglected in the discourses of academic communities and political elites. The inequality process is deeply rooted among humans and is part of many people's lives in the form of modern apartheid, gender segregation, lack of health access, and cultural gap. All those structural inequality processes are the product of the biopower perpetuated and produced in the macrosystem, exosystem, mesosystem, and microsystem. For many people from the academy, the information-consuming public, and the society in general, it is a problem to talk about these processes, since they have either lost interest or have normalized the structural and social inequity. For this reason, we see it as transcendental to explain how this situation occurs from the most internal fibers to the most evident processes, intending to make it more visible and thus expose the situation for possible solutions.
",isbn:"978-1-83768-406-9",printIsbn:"978-1-83768-405-2",pdfIsbn:"978-1-83768-407-6",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,isNomenclature:!1,hash:"cefab077e403fd1695fb2946e7914942",bookSignature:"Ph.D. Yaroslava Robles-Bykbaev",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11473.jpg",keywords:"Wage Gap, Gender Segregation, Fundamental Human Rights, Health Access, Social Inequity Processes, Modern Apartheid, Resilience, Cultural Gaps, Globalization, Geopolitics of Social Inequality, Public Policies, Social Vulnerability",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"June 15th 2022",dateEndSecondStepPublish:"July 13th 2022",dateEndThirdStepPublish:"September 11th 2022",dateEndFourthStepPublish:"November 30th 2022",dateEndFifthStepPublish:"January 29th 2023",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"9 days",secondStepPassed:!1,areRegistrationsClosed:!1,currentStepOfPublishingProcess:2,editedByType:null,kuFlag:!1,biosketch:"Dr. Bykbaev is a member of the UNESCO Chair of Politecnica Salesiana University. She has contributed as co-author and author to approximately thirty scientific publications in the field of statistics, inclusive education, and social and cultural anthropology. These publications focus on the visibility of problems in the field of public health and focus on the creation of proposals to improve community health. Dr. Bykbaev is an active member of the NODO Ecuadorian Network of Women Scientists (REMCI).",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"313341",title:"Ph.D.",name:"Yaroslava",middleName:null,surname:"Robles-Bykbaev",slug:"yaroslava-robles-bykbaev",fullName:"Yaroslava Robles-Bykbaev",profilePictureURL:"https://mts.intechopen.com/storage/users/313341/images/system/313341.jpg",biography:null,institutionString:"Politecnica Salesiana University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"Politecnica Salesiana University",institutionURL:null,country:{name:"Ecuador"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"23",title:"Social Sciences",slug:"social-sciences"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"444316",firstName:"Blanka",lastName:"Gugic",middleName:null,title:"Mrs.",imageUrl:"https://mts.intechopen.com/storage/users/444316/images/20016_n.jpg",email:"blanka@intechopen.com",biography:"As an Author Service Manager, my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact."}},relatedBooks:[{type:"book",id:"6926",title:"Biological Anthropology",subtitle:"Applications and Case Studies",isOpenForSubmission:!1,hash:"5bbb192dffd37a257febf4acfde73bb8",slug:"biological-anthropology-applications-and-case-studies",bookSignature:"Alessio Vovlas",coverURL:"https://cdn.intechopen.com/books/images_new/6926.jpg",editedByType:"Edited by",editors:[{id:"313084",title:"Dr.",name:"Alessio",surname:"Vovlas",slug:"alessio-vovlas",fullName:"Alessio Vovlas"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6942",title:"Global Social Work",subtitle:"Cutting Edge Issues and Critical Reflections",isOpenForSubmission:!1,hash:"222c8a66edfc7a4a6537af7565bcb3de",slug:"global-social-work-cutting-edge-issues-and-critical-reflections",bookSignature:"Bala Raju Nikku",coverURL:"https://cdn.intechopen.com/books/images_new/6942.jpg",editedByType:"Edited by",editors:[{id:"263576",title:"Dr.",name:"Bala",surname:"Nikku",slug:"bala-nikku",fullName:"Bala Nikku"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"314",title:"Regenerative Medicine and Tissue Engineering",subtitle:"Cells and Biomaterials",isOpenForSubmission:!1,hash:"bb67e80e480c86bb8315458012d65686",slug:"regenerative-medicine-and-tissue-engineering-cells-and-biomaterials",bookSignature:"Daniel Eberli",coverURL:"https://cdn.intechopen.com/books/images_new/314.jpg",editedByType:"Edited by",editors:[{id:"6495",title:"Dr.",name:"Daniel",surname:"Eberli",slug:"daniel-eberli",fullName:"Daniel Eberli"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"57",title:"Physics and Applications of Graphene",subtitle:"Experiments",isOpenForSubmission:!1,hash:"0e6622a71cf4f02f45bfdd5691e1189a",slug:"physics-and-applications-of-graphene-experiments",bookSignature:"Sergey Mikhailov",coverURL:"https://cdn.intechopen.com/books/images_new/57.jpg",editedByType:"Edited by",editors:[{id:"16042",title:"Dr.",name:"Sergey",surname:"Mikhailov",slug:"sergey-mikhailov",fullName:"Sergey Mikhailov"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1373",title:"Ionic Liquids",subtitle:"Applications and Perspectives",isOpenForSubmission:!1,hash:"5e9ae5ae9167cde4b344e499a792c41c",slug:"ionic-liquids-applications-and-perspectives",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/1373.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"65262",title:"The Adaptive Coding Techniques for Dependable Medical Network Channel",doi:"10.5772/intechopen.83615",slug:"the-adaptive-coding-techniques-for-dependable-medical-network-channel",body:'\nA medical telemonitoring system is one of the telecommunication techniques that access delivery to healthcare services and one of the main applications for Medical Information Communication Technology (MICT). Recently, Information and Communication Technology (ICT) for medical and healthcare application has drawn substantial attention, which plays an important role to support dependable and effective medical technologies to solve significant problems in any society. The WBAN technology has proved out newly in the latest standardization as IEEE 802.15.6 [1]. WBAN standard aims to provide an international standard for short range, low power, and extremely reliable wireless communication within the surrounding area of the human body, supporting an enormous range of data rates from 75.9 Kbps narrow band (NB) up to 15.6 Mbps ultra-wide band (UWB) for various sets of applications [2]. WBAN technology is growing as a key technology for MICT to transfigure the future of healthcare; therefore, WBANs have been attracting a great treaty of attentions from researchers both in academia and industry in the last few years [3]. A QoS is a major concern for WBAN medical application. Therefore, the researcher concerning QoS issues in WBANs should handle all of that very seriously in an effective way [4]. The cellular standards have been adopted by the European Union (EU) as a mandatory standard for member states and are spreading throughout much of the world. The cellular standards have been developed by considering enhancement in all aspects such as transmission speed, transmission way, data rate, error correction capabilities, channel capacity and QoS as general. UMTS is the main standard of the third generation (3G) with Wide Code Division Multiply Access (WCDMA) air interface, and LTE is the main standard of the fourth generation (4G). The bandwidth of a WCDMA is 5 MHz, and it is enough to provide data rates of 144 and 384 Kbps and even 2 Mbps in good conditions. On the other hand, LTE provides UL peak rates of 75 Mb/s, and QoS facilities permitting a transfer latency of less than 5 ms in the radio access network and supports accessible carrier bandwidth from 1.4 to 20 MHz. UMTS and LTE are used to cover both Frequency Division Duplex (FDD) and Time Division Duplex (TDD) operations and integrate a wide variety of wireless multimedia services with high data transmission rates, capable of providing much more than basic voice calls [5, 6, 7].
\nThe way to connect WBAN technology network with other networks such as cellular networks UMTS and LTE is a key point for this chapter to serve the WBAN medical data transmission through the readily existing cellular networks. Therefore, the concept is to use the error controlling coding and decoding based on the concatenated channel codes with the cellular readily existing codes to design the “Medical Network Channel (MNC)” system. Reliable transmission of medical data is critical and essential since it is related to diagnosis and treatments of human body diseases. In ICT field, the reliable transmission procedures must guarantee detection and correction of erroneous transmissions. However, the transmission channel is often subject to various disturbances and interferences from the external environment conditions (noise).
\nThe chapter focuses on the dependability of medical telemonitoring system from WBANs through UMTS and LTE via “Medical Network Channel (MNC)” system. Dependability of medical data transmission via MNC is defined as the probability of the “Medical Network Channel (MNC)” system to operate successfully, which means transmitted medical data reach their destination completely uncorrupted and guarantee minimum performances with lower error rate as much as possible under different environmental conditions. There are different methods that can be employed to overcome the channel impairments, such as increasing transmission power or the use of error control coding schemes in information theory field. A high level of reliability can be obtained by introducing redundancy bits in the signal transmission (encoding).
\nMedical Network Channel (MNC) system has been introduced to solve the reliability issues for medical data transmission when considering different QoS levels. The WBAN medical data are sensitive and any type of noise can corrupt them during transmission. Although the cellular standards include significant amounts of error detection and correction techniques, which are designed for daily life conversation mainly, some errors may still be present in the received data, and these transmission errors are not serious for the daily communication, but when considered for medical uses, they can have fatal outcomes. For that reason, the UMTS and LTE codes are designed for certain levels of channel condition, and if the error becomes more than the estimated condition, then the error becomes more serious and the cellular network standards perform worse using the preexisting error detection and correction capability. The Medical QoS levels have different reliability required based on the BER for different medical data and other constraints [8].
\nThe error control coding plays an important role in modifying the reliability issues. The concatenated codes are one of the error control coding techniques that have been widely adopted due to their simplicity and effectiveness [10]. Therefore, the chapter proposes a novel way of conducting error control encoding and decoding with QoS constraints by using the concatenated code techniques to build the MNC system. Consequently, the MNC intends to add extra channel code in order to combine the WBANs and the cellular networks and optimize the technical parameters for this extra channel depending on the reliability required for the medical data QoS levels and channel conditions as well. Therefore, the adaptive external channel code choice has six pairs of encoding and decoding, three for QoS levels (high, medium, and low) and then two for the channel condition (normal and worse). The restriction of UMTS or LTE channel codes is a standard, which is fixed by the European Telecommunication Standard Institute (ETSI) [5, 6, 7]. The technical parameters cannot be changed in order to provide good system performance. The only way is to design and optimize good adaptive extra outer channel codes with strong decoding capabilities resulting in better performance for MNC to transmit the WBAN medical data robustly.
\nThe objective of the chapter is to design a reliable and dependable MNC system through the cellular networks to provide reliable transmission for all QoS medical data coming from WBANs. The structural design of MNC is based on channel coding of those using concatenated channel code techniques in the serial manner which adds extra channel codes to the cellular UMTS or LTE codes. The inner channel codes in MNC are cellular network standard UMTS or LTE error correction codes that cannot be changed in order to enhance the error performances, with regard to the international standards. On the other hand, the extra outer channel code in MNC is a changeable parameter for achieving different QoS constraints of medical data, which used the convolution code as the main error correction technique. Then, it will add end-to-end connection of WBANs to this MNC system using WBAN standard error correction techniques itself. According to QoS of WBANs O/P, MNC can be with or without extra code.
\nThis chapter reflects about categorizing the eighth level QoS of WBANs to three different QoS (lower, medium, and higher) set levels. To achieve the chosen QoS, there is a need for adaptive external code with limited or strong error correcting capability with high, medium, or low coding rate and redundancy. Through those techniques, the MNC system is adaptive to varying propagation conditions and also adaptive to various QoS constraints. Therefore, the work here focuses to overcome different PHY errors that may occur during the transmission in an unpredictable way, making the channel situation time-to-time change, such as Gaussian noise AWGN, Rayleigh fading, or burst noise.
\nThe “Medical Network Channel (MNC)” system is a new system adopted in this chapter, which works to serve transmission of medical data robustly from WBANs through the cellular standard networks. It is mainly based on the error control coding techniques to ensure the dependability required for such medical data. The idea of the concatenated codes was used for connecting the WBANs with the cellular networks. The purpose is to have reliable and dependable medical data transmissions through the readily existing cellular network.
\n\n\nFigure 1\n shows the whole “Medical Network Channel (MNC)” system that is the core base of this chapter. The different medical data QoS levels from the WBANs have been considered in designing the phase as well as the different assumed channel conditions. The structural design of the proposal is described in \nFigure 2\n by using the concatenated code techniques for different QoS of WBANs. The inner code for the MNC structure is introduced in \nTable 1\n. The UMTS and LTE provide both error detection and error correction as channel coding scheme. Here, it is assumed that the inner channel of the “Medical Network Channel (MNC)” system uses uplink UMTS channel as Common Packet Channel (CPCH) working by the convolution code rate 1/2. Similarly, the downlink UMTS channel was assumed using Forward Access Channel (FACH) working by the convolution code rate 1/3. Furthermore, LTE was assumed using Broadcast Channel (BCH) working by the convolution code rate 1/3.
\nMedical network channel codes via cellular networks.
The medical network channel system for QoS of WBAN medical data.
\n | TRCH type | \nCoding type | \nCoding rate R and constraint length K | \nNumber of encoded bits | \n
---|---|---|---|---|
\n | \nCPCH | \nConvolution | \nR = 1/2 & K = 9 | \nDi = 2*Ki + 16 | \n
\n | \nFACH | \nConvolution | \nR = 1/3 & K = 9 | \nDi = 3*Ki + 24 | \n
\n | \nBCH | \nConvolution | \nR = 1/3 & K = 7 | \nDi = 3*Ki + 18 | \n
The inner cellular network code techniques.
The technical parameters for the extra channel detailed here by using extra outer encoder as convolution encoder are concatenated to the inner cellular standard channel codes. Among all the FEC codes, the convolution codes have great advantages using continuous data streams and can manage the performance with only two parameters: the code rate R and the constraint length K. Also, convolution codes have high error correction in comparison to block codes and less complexity in comparison to turbo codes. The soft decoding algorithm and the hard decoding algorithm, can make easily changes in the performances. Since the extra channel is a key point to have high performance for “Medical Network Channel (MNC)”-proposed system, the choice here of the extra code is driven by convolution codes. The outer channel is the existing WBAN channel that uses BCH code as a main code to correct the error. The system “Medical Network Channel (MNC)” has been considering the performance with and without end-to-end connection of the WBAN codes. The assumption is that the medical data coming from the WBANs with transmission rate 75.9Kb/s are entering the extra outer channel that will be the only optimized channel in “Medical Network Channel (MNC)” system, and then are entering the inner cellular channels within data rate less than the channel capacities.
\nThe “Medical Network Channel (MNC)”-proposed system is dependable, which ensures to give the different QoS level of medical data transmission within acceptable performance capability such as 10−3,10−5 and 10−7 BER for low, medium, and high QoS levels within higher required bit energy to interference (Eb/No) values as possible under different assumed noise conditions. The WBAN has eight QoS levels. The QoS levels for the medical data have divided to three parts as lower priority QoS level, medium priority QoS level, and higher priority QoS level. Depending on these priority levels, the proposed system MNC has been designed as shown in \nFigure 2\n.
\n\n\nTable 2\n shows all the error-correcting capabilities related to the UL and DL inner channels’ technical capabilities for the UMTS and LTE with regard to the international standards of error correction code.
\n\n | Data rate | \nR | \nK | \nG | \nDfree\n | \nError (t) | \nGuard space (g) | \nTrellis paths (E) | \nSum Wd\n | \n
---|---|---|---|---|---|---|---|---|---|
\n | \n144Kb/s | \n1/2 | \n9 | \n[561 753] | \n12 | \n6 | \n\n\n | \n256*L | \n122,694 | \n
\n | \n144Kb/s | \n1/3 | \n9 | \n[557 663 711] | \n18 | \n9 | \n\n\n | \n256*L | \n2275 | \n
\n | \n75 Mb/s | \n1/3 | \n7 | \n[133 171 165] | \n15 | \n7 | \n\n\n | \n64*L | \n416 | \n
The inner cellular network code capabilities.
The criteria of the extra code selections in “Medical Network Channel (MNC)” system have two main parts in the structure: the fixed parts, which are related to the cellular standard networks or WBAN technology, and the changeable parts, which are external that are added to receive the medical data only.
\nThe assumption in this chapter is a WBAN chip installed in the mobile device to carry-on the medical data via the cellular systems through the “Medical Network Channel (MNC)” system to ensure the reliability required for the different sets of medical data. The extra code is adaptive by carrying parameters that are selectable with regard to the two main requirements: first, with regard to various kinds of the QoS of medical data entering the extra code from the WBAN code and second, with regard to the kind of the channel conditions that affected the transmission in PHY channels.
\nThe goal of “Medical Network Channel (MNC)” is figured out by designing the extra code with regard to the QoS by analyzing the WBAN medical data QoS needed. \nTable 3\n categorizes the QoS of the WBAN medical data into three sets, with regard to the priority level, in order to design the MNC system. The first set is the highest priority level such as a biological signal (ECG, EMG, and EEG), the second set is a medium priority level such as medical data (temperature, blood pressure, and blood sugar), and the third set is the lowest priority level such as data management, audio, and video.
\nQoS data sets | \nCode | \nR & K | \nG | \ndfree\n | \nt | \nSum Wd\n | \nII Size | \n
---|---|---|---|---|---|---|---|
\n | \n\n | \n1/2 & 8 | \n[247 371] | \n10 | \n5 | \n10,970 | \n126 bits/block | \n
\n | \nOuter | \n1/3 & 8 | \n[225 331 367] | \n16 | \n8 | \n425 | \n189 bits/block | \n
\n | \n\n | \n1/4 & 8 | \n[235 275 313 357] | \n22 | \n11 | \n169 | \n252 bits/block | \n
Designing parameters of MNC adaptive codes related to QoS priority levels.
“Medical Network Channel (MNC)” used the three sets later to design and optimize the MNC system depending on that. The first set highest priority level will carry on through strong design MNC achieving 10−7 BER, then the second set medium priority design system achieves 10−5 BER, and then the third set lowest priority design system achieves 10−3 BER within higher Eb/No as possible.
\nIn the “Medical Network Channel (MNC)” super PHY channel, the remaining error from the inner cellular decoder optimized the technical parameters of the extra outer code as shown in \nTable 3\n.
\nThe system design that is detailed above has been adjusted for the different QoS levels of medical data. The technical parameters of the extra channel codes have been fixed for the “Medical Network Channel (MNC).” The capabilities have been determined for the AWGN channel and for the Rayleigh fading with a parameter distribution function equal to 0.55. However, for seeking the reality, these channel conditions may be good or worse than those determined. \nTable 4\n details all the “Medical Network Channel (MNC)” adaptive design parameters with regard to the capability of correcting the channel errors.
\nI/P | \n100 Kb/s [51 bits/s length] | \n||
---|---|---|---|
\n | \n\n | \n||
\n | \n\n | \n\n | \n\n | \n
\n | \n(2,1,8) Dfree 10 T = 5 I/P 63b/s O/P 126 b/s | \n(3,1,8) Dfree 16 T = 8 I/P 63b/s O/P 189 b/s | \n(4,1,8) Dfree 22 T = 11 I/P 63b/s O/P 252 b/s | \n
\n | \n(2,1,9) Dfree 12 T = 6 I/P 126 b/s O/P 252 b/s | \n(2,1,9) Dfree 12 T = 6 I/P 189 b/s O/P 378 b/s | \n(2,1,9) Dfree 12 T = 6 I/P 252 b/s O/P 504 b/s | \n
\n | \n(3,1,9) Dfree 18 T = 9 I/P 126 b/s O/P 378 b/s | \n(3,1,9) Dfree 18 T = 9 I/P 189 b/s O/P 567 b/s | \n(3,1,9) Dfree 18 T = 9 I/P 252 b/s O/P 756 b/s | \n
\n | \n(3,1,7) Dfree 15 T = 7 I/P 126 b/s O/P 378 b/s | \n(3,1,7) Dfree 15 T = 7 I/P 189 b/s O/P 567 b/s | \n(3,1,7) Dfree 15 T = 7 I/P 252 b/s O/P 756 b/s | \n
All error-correcting capabilities for MNC-proposed system codes.
The error-bound probabilities are calculated depending on the inner, outer, and extra outer decoders separately. Continuously, the code performance is analyzed in terms of decoded BER. BER is normally calculated as a function of Eb/No. Here Eb represents the average energy transmitted per information bit and No represents the single-sided power spectral density of the assumed AWGN channel.
\nThe performance bounds theoretically are driven under AWGN with and without adding WBANs end to end to “Medical Network Channel (MNC)”-proposed system. Then, the performance bounds theoretically are driven under Rayleigh fading channel without adding WBANs end to end; this step is only to demonstrate the feasibility of the “Medical Network Channel (MNC)” system and to find out the numbers of errors in the output of inner cellular decoders and to test the optimized extra channel code theoretically in “Medical Network Channel (MNC)” for different QoS medical data levels under AWGN and Rayleigh fading channels.
\n\n\nTable 5\n explains all the technical parameters used in the theoretical evaluations. The theoretical bound follows number of steps to calculate the error probabilities for the adaptive “Medical Network Channel (MNC)” concatenated channel codes: the first step in the O/P of the inner cellular decoders, then second in the O/P of the extra channels decoders (the three sets for different QoS levels), and at last, in the O/P of the WBAN outer decoders. These numerical evaluations have been done in the two assumed inner cellular channel codes: UMTS and LTE.
\nQoS data | \nCode | \nR & K | \nG | \ndf\n | \n\n\n | \nSum of Wd\n | \n
---|---|---|---|---|---|---|
\n | \n\n | \n1/3&7 | \n[133 171 165] | \n15 | \n29!/15! × 14! 77558760 | \nWd = ∑[7 8 22 44 22 94 219] = 416 | \n
\n | \nInner | \n1/2&9 | \n[561 753] | \n12 | \n23!/12! × 11! 1352078 | \nWd = ∑ [33 281 2179 15035 105166] = 122694 | \n
\n | \n\n | \n1/3&9 | \n[557 663 711] | \n18 | \n35!/18! × 17! 4.5376e+009 | \nWd = ∑[11 32 195 564 1473] = 2275 | \n
\n | \n\n | \n1/2&8 | \n[247 371] | \n10 | \n19!/10! × 9! 92378 | \nWd = ∑[2 22 60 148 340 1008 2642 6748] = 10970 | \n
\n | \nOuter | \n1/3&8 | \n[225 331 367] | \n16 | \n32!/16! × 15! 300540195 | \nWd = ∑[1 24 113 287] = 425 | \n
\n | \n\n | \n1/4&8 | \n[235 275 313 357] | \n22 | \n43!/22! × 21! 1.0520e+012 | \nWd = ∑[2 10 108 10 11 54 64] = 169 | \n
Error correcting code capabilities for MNC system.
The theoretical calculations for the error bound of the “Medical Network Channel (MNC)”-proposed system via AWGN could be done as many steps in the decoding side as in (Eq. (1)–(11)). The inner and extra channel used convolutional decoder that works using Viterbi algorithm and the outer WBAN channel used the block code decoder. First of all, the UMTS inner decoder calculates the first inner probability bit errors
where
where
Generally speaking, the data stream coming from the cellular inner codes feed to the extra outer codes. The code performance of the extra outer code is a function of the cellular inner code. Second, the extra outer decoder calculates the second outer probability bit errors
The outer code performances of the MNC system can be calculated by Eq. (6) for lower, medium, and higher QoS classes of medical data depending on the parameters applied to the extra channel. The last step is introduced by calculating the final outer code performance of the system. The WBAN decoder (63, 51, 2) calculates the last probability bit error
By using Eq. (9) as a function of Eq. (6) to calculate the final bound, we can have Eq. (10).
\nThen, by applying Eq. (10) in Eq. (7), we will have the final MNC system by adding WBAN code end to end for all QoS assumed and via AWGN channel in Eq. (11).
\nThe theoretical calculations for the error bound of the MNC system via Rayleigh fading channel could be done by the same steps of calculating it via AWGN channel without end-to-end connection of the WBANs. For this part, the
where \n
where
Generally speaking, the data stream coming from the cellular inner code feeds the extra channel code. The code performance of the extra outer code is a function of the inner cellular code. Second, the outer decoder calculates the second outer probability bit errors
Then, the extra outer code performances of super PHY channel MNC system under Rayleigh fading can be calculated by Eq. (19).
\nThe theoretical performances have been calculated for the MNC system with different QoS levels by using the cellular standards as an inner code via AWGN and Rayleigh fading noisy channels.
\nThe first case is via WBANs. In this case, where the inner codes work as a UMTS channel, there are two kinds of codes, when using the cellular parameters in \nTable 2\n. One is the error probability as in Eq. (20) for UL and other is the error probability as in Eq. (21) for DL.
\nIn the second step in the O/P of the extra channel code, there are three targeting QoS levels. Therefore, the probability of the error can be calculated from Eq. (5) as in Eq. (22)–Eq. (24) for the different code sets.
\nFrom here, the error probability for the “Medical Network Channel (MNC)”-proposed system without end-to-end connection of WBANs can be calculated from Eq. (6) as six levels of error probability as in Eq. (25).
\nThe final steps here can be done when the WBANs are connected end to end through the system. Therefore, using Eq. (25) in Eq. (11), we can have the final error probability of the system.
\nThe second case is via WBANs. In this case where the inner codes work as an LTE channel, when using the LTE cellular parameters in \nTable 2\n, we will have the probability of errors as in Eq. (27).
\nIn the second step in the O/P of the extra channel code, there are three targeting QoS levels. Therefore, the probability of the error can be calculated from Eq. (5) as in Eq. (22)–(24) for the different code sets. From here, the error probability for the MNC system without end-to-end connection of WBANs through the LTE can be calculated from Eq. (6) as six levels of error probability as in Eq. (28).
\nThe final step here can be done when the WBANs are connected end to end through the proposed system. Therefore, using Eq. (28) in Eq. (11), we can have the final error probability of the “Medical Network Channel (MNC)” system.
\nThe third case is via Rayleigh fading. In this case where the inner codes work as a UMTS channel, there are two kinds of codes: UL and DL. By using the cellular parameters, we will have the probability of errors as in Eq. (30) in the case of UL and Eq. (31) in the case of DL.
\nIn the second step in the O/P of the extra channel code, there are three targeting QoS levels. Therefore, the probability of the error can be calculated from Eq. (18) as in Eq. (32)–(34).
\nFrom here, the error probability for the “Medical Network Channel (MNC)”-proposed system without end-to-end connection of WBANs could be calculated from Eq. (19) as three levels of error probability as in Eq. (35).
\nThe fourth case is via Rayleigh fading. In the case where the inner codes work as an LTE channel, when using the cellular parameters in Eq. (17), we will have the probability of errors as Eq. (36).
\nThen, from here, the error probability for the “Medical Network Channel (MNC)” system without end-to-end connection of WBANs can be calculated from Eq. (19) as three levels of error probability as in Eq. (37).
\nFinally, \nTable 6\n shows the numerical evaluation of the “Medical Network Channel (MNC)” system with different categories, with the inner channel as UMTS UL, DL, and LTE as well. Regarding to the figures results, \nFigure 3\n shows the theoretical performance when the channel is affected by AWGN for MNC via UMTS networks. \nFigure 4\n shows the theoretical performance when the channel is affected by Rayleigh fading for MNC via UMTS networks. \nFigure 5\n shows the theoretical performance when the channel is affected by AWGN for MNC via LTE networks. Finally, \nFigure 6\n shows the theoretical performance when the channel is affected by Rayleigh fading for MNC via LTE networks.
\nThe results via AWGN | \n||||||
---|---|---|---|---|---|---|
Eb/No\n | \n0 dB | \n1 dB | \n2 dB | \n3 dB | \n4 dB | \n5 dB | \n
WBANs | \n0.1763 | \n0.1379 | \n0.0933 | \n0.0515 | \n0.0215 | \n0.0062 | \n
LTE | \n0.3256 | \n0.0807 | \n0.0143 | \n0.0017 | \n0.0001 | \n0.0000 | \n
Low-QoS | \n2.7957 | \n0.1717 | \n0.0054 | \n0.0001 | \n0.0000 | \n0.0000 | \n
Medium-QoS | \n0.0755 | \n0.0042 | \n0.0001 | \n0.0000 | \n0.0000 | \n0.0000 | \n
High-QoS | \n0.0251 | \n0.0014 | \n0.0000 | \n0.0000 | \n0.0000 | \n0.0000 | \n
Low-QoS-WBANs | \n1.0000 | \n0.0506 | \n0.0000 | \n0.0000 | \n0.0000 | \n0.0000 | \n
Medium-QoS-WBANs | \n0.0127 | \n0.0000 | \n0.0000 | \n0.0000 | \n0.0000 | \n0.0000 | \n
High-QoS-WBANs | \n0.5854 | \n0.0000 | \n0.0000 | \n0.0000 | \n0.0000 | \n0.0000 | \n
\n | \n||||||
Eb/No\n | \n0 dB | \n1 dB | \n2 dB | \n3 dB | \n4 dB | \n5 dB | \n
UMTS-UL | \n4.9532 | \n0.0001 | \n0.0000 | \n0.0000 | \n0.0000 | \n0.0000 | \n
Low-QoS | \n1.9352 | \n0.0000 | \n0.0000 | \n0.0000 | \n0.0000 | \n0.0000 | \n
Medium-QoS | \n9.0438 | \n0.0000 | \n0.0000 | \n0.0000 | \n0.0000 | \n0.0000 | \n
High-QoS | \n4.5376 | \n0.0000 | \n0.0000 | \n0.0000 | \n0.0000 | \n0.0000 | \n
Theoretical error bit performances for MNC system.
All priority results via UMTS under AWGN theoretically.
All priority results via UMTS under Rayleigh fading theoretically.
All priority results via LTE under AWGN theoretically.
All priority results via LTE under Rayleigh fading theoretically.
The main purpose of “Medical Network Channel (MNC)” systems is to have a reliable medical network channel via the cellular infrastructure networks by end-to-end WBAN connection. Therefore, the stanchions establishment of “Medical Network Channel (MNC)” with error controlling coding and decoding through existing infrastructure networks such as UMTS and LTE is introduced in this chapter with an end-to-end connection of WBANs and without the connection of WBANs considering the medical data coming from different sources. The understanding of the eight levels of the QoS medical data has been done well; however, the optimizations here have been classified into three classes (lower, medium, and higher) for all medical QoS data. Therefore, the MNC system is a novel way considering the dependability issues by this way for the first time with regard to the QoS constraint for the different medical applications of WBANs. Although the adaptive extra outer code for “Medical Network Channel (MNC)” is based on the convolution code, the choice of the technical parameters is different from one to another depending on the QoS targeted and on the capability of cellular standard itself, which is a remaining error in the O/P of the inner cellular code.
\nAlthough the current cellular standard has strong error detection and correction capability, it is designed well for the daily life communication without considering medical data transmission, and in some hard noisy channel situations that exceed the design capabilities, the cellular network cannot perform well. Therefore, the Medical Networks channel MNC system has been introduced new novel approach to connect WBANs end-to-end via the cellular networks by providing very large BER for the different assumed QoS levels of medical data to be transmit robustly and achieving the enhancement Eb/No gap under all the environments condition that assumed in compare to conventional cellular system alone. Then the adaptive “Medical Network Channel (MNC)” system overcomes the weakness of cellular networks with regard to the dependability issues and provides even better performance than the cellular network for the purpose of medical data transmission. These performances allow MNC equivalence for transmitting medical data by the highest possible level of the dependability required. In regard to achieving different QoS of WBAN requirements, the results in \nTable 6\n and BER \nFigures 3\n–\n6\n cleared all the study cases carefully for adaptive “Medical Network Channel (MNC)” system. Generally, the adaptive medical network channel introduced in this chapter is through the cellular networks. However, all communication network standards can be applied using error correcting techniques to be adaptive for medical data transmission.
\nThe first author would like to express thanks to the academic supervisor Prof. Ryuji Kohno for his help and guidance and to all Kohno-Lab members in Yokohama National University. Correspondingly, the first author would like to express thanks to the dean and engineering members in Sudan International University.
\nThere is no conflict of interest for this work from anyone.
Electrospinning is the most preferred method because of its low cost compared to nanofiber production methods, production of long and continuous nanofibers, controllable nanofiber diameter, and industrial processing potential. When all these properties are evaluated, it would be appropriate to produce a nanofiber for wound healing by electrospinning. On the other hand, in recent years, interest in polymer materials obtained by the electrospinning method has increased significantly. Materials such as polymers and nanofiber composites can be produced directly by electrospinning. The post-processing of electrospun fibers forms other materials, such as ceramics and carbon nanotubes [1]. Polymer nanofibers obtained by the electrospinning method have a high surface area-volume ratio, flexible in surface functions, have superior mechanical performance, and are versatile in design [2].
Because of all these advantages, the most common and simple method used for tissue framework production is electrospinning. The principle of operation is based on filling the syringe with the polymer solution or melting in the high potential area and spraying it from the tip of the syringe to the collector by applying a voltage to an electrode connected to the tip of the syringe (Figure 1). Here, since the solution sprayed from the syringe is subjected to an electrical field, it elongates at the tip of the needle, and a conical appearance called a Taylor cone is obtained. A typical electrospinning process must be between a high voltage source with positive or negative polarity and a grounded surface so that the fibers can clump together. Spraying the solution in the syringe starts when the potential difference applied from the voltage source reaches the threshold value and equalizes to the electrostatic forces, and is completed by spraying it on the grounded surface. Since the fibers collected on the surface are sprayed with a high amount of pulling, they should be in a fine and regular structure [3, 4, 5].
Schematic representation of the electrospinning process.
The surface tension of the liquid (γ), and the gravitational force (Fg) affect the droplet when the solution, which is the first step of the electrospinning process, comes out of the syringe by forming a droplet. The capillary of internal radius (R), density of the liquid (ρ), and gravitational constant (g) values of the pipe through which the polymer flows are effective in the formation of the radius of the droplet (r0).
When a sufficiently high voltage is applied, the electric force FE, the gravitational force Fg encounter surface forces (Fγ = FE + Fg), and the radius of the droplet decreases from (r0) to r (r < r0) [6].
After droplet formation, the polymer solution overcomes the surface forces under the influence of Coloumb repulsive forces, forming a Taylor cone with an apex angle of 49.3°. Initially straight, the jet segment may become unstable over time and may show twisting and undulating movements as it passes toward the collector. The jet in this region exhibits components of predominantly non-axial electrostatic repulsion forces. Three types of instability can occur as demonstrated by the polymer jet. These instability forms are listed as classical Rayleigh instability, axisymmetric electric field current, and whipping instability. Whipping instability results in a radial torque from the center of the jet, resulting in a high degree of bending instability. The resulting radial jets push each other and separate from the main jet. The interaction between increasing charge density on the one hand and viscous and surface tension forces resisting elongation on the other determines the complexity of the resulting instability [6, 7].
This chapter focused that the electrospinning process, parameters affecting the process such as solution and ambient. After then, it was explained herbal extracts were used to obtain nanofibers by electrospinning method and their application areas. This chapter will provide an overview of the principles of the electrospinning process with various herbal extracts for potential applications in many fields especially biomedical areas.
There are three main parameters of the electrospinning process. These are due to the polymer solution, process, and environmental conditions. In this section, the factors affecting each parameter will be discussed in detail. These parameters and their effects in Table 1 are also shown.
Parameters | Effect of Fiber Morphology |
---|---|
Solution Viscosity ↑ | Fiber Diameter ↑ (within the optimum range) |
Surface Tension↓ | Fiber Diameter ↑ |
Solution Conductivity ↑ | Fiber Diameter ↓(wide diameter distribution) |
Solution Dielectric Constant↑ | Fiber Diameter ↓ |
Voltage ↑ | Fiber Diameter ↓ later ↑ |
Flow Rate ↑ | Fiber Diameter ↑ (if the flow rate is too high, a bead appearance occurs.) |
Temperature↑ | Fiber Diameter ↓ (as the viscosity will decrease) |
Distance Between Tip and Collector↑ | Fiber Diameter ↓ (if the distance between the tip and the collector is too short, a bead appearance occurs) |
Humidity (Moisture) ↑ | Fiber Diameter ↑ (with the optimum range) |
Electrospinning parameters affecting fiber morphology.
To carry out the electrospinning process, the polymer must be in liquid form, in the form of a molten polymer or polymer solution. The physical and chemical properties of the solutions play an active role in the electrospinning process and the resulting fiber morphology. During the electrospinning process, the polymer solution is drawn from the tip of the needle. For this reason, the electrical properties, surface tension, and viscosity of the solution determine the amount of stress in the solution. The evaporation rate also affects the viscosity of the solution as it is stretched. The solubility of the polymer in the solvent determines not only the viscosity of the solution but also the types of polymers that can be mixed with each other [1].
Viscosity is the most important factor determining the flow rate of the solution. In the electrospinning process, the flow rate increases at low viscosity [8]. However, when the viscosity of the solution is too low, fluidity may occur and polymer particles may form instead of fibers. In solutions with lower viscosity, the polymer chain is generally less synthesized with each other [9], less chain entanglement occurs, and thus jet stability is lost. The fibers are collected into the collector as droplets, which first turn into spindle-like structures and then into beaded nanofibers [3]. As the viscosity increases, the formation of the bead structure decreases, and more regular nanofibers are obtained [9]. Therefore, factors that affect the viscosity of the solution also affect the electrospinning process and the resulting fibers.
The molecular weight of the polymer used in the electrospinning process has a direct effect on properties such as viscosity, surface tension, and conductivity, and this interaction determines the nanofiber formation. Molecular weight is explained as the length of the chains of the polymer from which nanofibers will be obtained [4]. The length of the polymer chain will determine the amount of entanglement of the polymer chains in the solvent [1]. Since the viscosity will be higher in polymer solutions with high molecular weight, the formation of beads decreases [10]. Although the increase in molecular weight provides regular fiber formation, if this increase is high, it causes the formation of microstrip structure [11, 12].
When a very small drop of waterfalls into the air, the droplet usually takes on a spherical shape. The liquid surface property that causes this phenomenon, which occurs when the electrical forces are around zero, is known as surface tension [1]. An excessive increase in surface tension adversely affects the electrospinning process. Some surfactants with low concentrations are used to lower the surface tension. The decrease in the surface tension of the solution ensures the formation of finer and smoother fibers and a problem-free electrospinning process [4]. The concentration change in the solutions used directly affects the surface tension [13].
Electrospinning is a method of obtaining nanofibers that repel the charges on the surface by stretching the solution and transfer the electric charge from the electrode to the polymer solution [1, 14]. In the electrospinning system, low electrical conductivity can form beaded fibers as it will create instability and cause the jet to not be able to extend sufficiently, while with high electrical conductivity, the polymer jet can stretch more with the loads it carries and form fibers with a smoother and finer structure [3]. For this reason, it is aimed to increase the electrical conductivity by increasing the concentration. Some additives can also be added to increase conductivity in low-concentration or insufficiently ionic solutions [4]. If the conductivity of the solution increases, the electrospinning jet can carry more charge. For example, the conductivity of the solution can be increased by the addition of ions [1]. By adding salt to an uncharged solution, although electrical neutrality is maintained, salt molecules can dissociate into independently acting positive and negative ions, thereby increasing the electrical conductivity of a solution [15, 16]. These ions can also be obtained by dissolving most drugs or proteins in water. As a result, when a small amount of salt or polyelectrolyte is added to the solution, the increased loads carried by the solution will increase the stretching of the solution and the formation of beaded fibers will be prevented [1].
The insulation constant or dielectric constant is defined as a coefficient that measures the ability of a material to store charge on it [17]. As the dielectric constant of the solutions increases, the charge distribution across the surface of the bubble formed at the needle tip will be more uniform, as there will be more net charge density. Therefore, the ordered structure of the obtained nanofiber is also increasing [3, 4]. It is thought that as the dielectric constant increases, obtaining finer and smoother fibers is due to the application of more tension force to the fluid jet [18].
Another important parameter affecting the electrospinning process is various external factors applied to the electrospinning jet. These factors are voltage, flow rate, temperature, collector effect, nozzle diameter, and the distance between the tip and the collector. Although these parameters are less important than solution parameters, they have a certain effect on fiber morphology.
Voltage is a parameter that induces charges in the solution, overcomes electrostatic forces, and initiates the electrospinning process [1]. As the amount of applied voltage increases, the diameters of the obtained nanofibers will decrease [4]. There are three main reasons for this. The first reason is because of a higher voltage will lead to greater stretching of the solution due to the larger columbic forces in the jet and the stronger electric field. This will reduce the fiber diameter. The second factor is that by using a lower viscosity solution, at a higher voltage, the formation of secondary jets during electrospinning is achieved. Thus, the fiber diameters can become narrower. Another factor that can affect the fiber diameter is the flight time of the electrospinning jet. A longer flight time will allow more time for the fibers to stretch and elongate before being placed on the collecting plate. Therefore, at a lower voltage, the diminished acceleration of the jet and the weaker electric field can increase the flight time of the electrospinning jet, facilitating the formation of finer fibers [1].
In many studies [19, 20, 21], it was observed that the formation of beads on the surface formed with the increase of voltage increased. The increase in bead density due to tension is explained because of increased instability of the jet as it is drawn into the syringe needle in the Taylor cone [1]. Here, bead formation occurs with the excessive acceleration of voltage increase, jet movement, and evaporation [4]. It is also suggested that increasing voltage will increase bead density and at even higher voltage, beads will form fibers of thicker diameter [1].
Despite these studies that the voltage increase creates a bead surface, it has been observed that the production of nanofibers at very low voltage also creates a beaded surface [22]. In this sense, the important thing is to work at a voltage where the flow balance will be stable. With the increase in voltage, the jets coming out of the cone tip reach the collector in an orderly manner, increasing their speed in the electrical field. Here, excessive speed increase or decrease is a factor that will lead to the formation of a beaded surface. In other words, the applied voltage must have an upper and lower limit.
The feeding rate determines the amount of feed in the electrospinning system. A certain feeding rate is needed to maintain the Taylor cone in the system. When the feeding rate increases, there will be an increase in the fiber diameter or the size of the beads formed in the fibers, as there will be more solution volume at the nozzle tip [1]. At low feeding rate, nanofiber production will not be possible because there will not be sufficient feed for the Taylor cone.
As the applied voltage changes, the resulting Taylor cone will also change. At low applied voltages, a hanging drop forms at the tip of the array. The Taylor cone is then formed at the tip of the array. However, as the applied voltage increases (moving from left to right), the volume of the hanging drop decreases until a Taylor cone is formed at the tip of the array. Increasing the applied voltage results in the ejection of the spray through the syringe, which is associated with an increase in bead formation [5].
The temperature parameter consists of three environmental variables: melt temperature, solution temperature, and ambient temperature. As the melt temperature increases, less tension is required due to the decrease in viscosity and fiber diameters decrease [7]. Similar to melt temperature, the temperature of a solution has the effect of both increasing the evaporation rate and reducing the viscosity of the polymer solution. This is because the solution has a lower viscosity and greater solubility of the polymer in the solvent, allowing the solution to be stretched more evenly. With a lower viscosity, Columbic forces can exert a greater tensile force on the solution, thus resulting in smaller diameter fibers [1].
There must be an electric field between the source and the collector (collector) for the electrospinning process to start. Therefore, in most electrospinning systems, the collector plate is made of a conductive material such as aluminum foil, which is electrically grounded such that there is a constant potential difference between the source and the collector. If a non-conductive material is used as a collector, charges from the electrospinning jet will quickly build upon the collector, resulting in less fiber deposition. Fibers collected on non-conductive material generally have a lower packing density than those collected on a conductive surface. This is due to the repulsive forces of the loads that build upon the collector as more fibers accumulate. For a conductive collector, the loads on the fibers are distributed so that more fibers are drawn into the collector. As a result, the fibers can be wrapped closely together [1].
The most commonly used collector types in the electrospinning method are generally flat plates, grids and frames. Apart from these, rotating cylinder, rotating disc, rotating cones, parallel rings, liquid bath and wrapper, pyramid-shaped platform, conveyor belt, two parallel frames, rotor, and thin conductive rod are listed as [7].
The nozzle diameter has a certain effect on the electrospinning process. As the nozzle diameter gets smaller, it provides clogging of the diameter and reduces the amount of beads on the nanofibers. The reduction in occlusion is due to less exposure of the solution to the atmosphere during electrospinning. The decrease in the inner diameter of the hole causes a decrease in the diameter of the nanofibers. As the size of the droplet at the tip of the hole decreases, the surface tension of the droplet increases. It reduces jet acceleration when the same amount of voltage is applied, allowing more time for the solution to stretch and stretch before the collector. The nanofibers formed in this way are finer [1].
The nozzle could be blockage when electrospinning with electrospinning chloroform solutions of PLA. When more than one nozzle is formed, the solvent density may increase, but this will increase the difficulty of solvent removal and nozzle cleaning and compose the deposition of nonwoven fiber in thicknesses >10 mm [23].
The distance between the needle tip and the collector provides the necessary time for the solvent in the polymer jet sprayed from the nozzle tip to evaporate [4]. Changing the distance between the tip and the collector has a direct effect on both the flight time and the electric field strength. As the distance between the tip and the collector decreases, the jet will have a shorter distance to travel before reaching the collector plate. In addition, the electric field strength will increase at the same time, which will increase the acceleration of the jet going to the collector. As a result, there may not be enough time for solvents to evaporate when they hit the collector. When the distance is too low, excess solvent causes the fibers to coalesce where they come into contact [1].
Environmental conditions in the electrospinning process are the factors affecting the electrospinning process. In this sense, humidity, atmospheric type, and pressure cause physical and morphological changes in the formed fibers.
The increase in humidity in the environment adversely affects the electrospinning process. High humidity causes circular pores to form on the nanofiber surfaces obtained. The pore depth increases with increasing humidity. However, the depth, diameter, and number of pores remain constant above a certain humidity [1]. It is not possible to carry out the electrospinning process at very high humidity values [3]. As the humidity level decreases, volatile solvents evaporate quickly, causing drying and making the electrospinning process difficult [9]. For this reason, keeping the humidity level at an optimum level is an important factor.
The type of atmosphere in which the electrospinning process takes place is very important for the smooth running of the process. Different gases have different behavior under the high electrostatic field. For example, helium decomposes under a high electrostatic field and therefore electrospinning is not possible [1]. For another example, with excessively volatile solvents the Taylor cone could dry out. To prevent evaporation in the cone, it is feasible to introduce a local stream of solvent-saturated gas around the cone [23]. The decrease in pressure in the environment adversely affects the electrospinning process [1].
Pressure changes in the electrospinning process make it difficult to ensure the stability of the drafting process. The reduction in pressure surrounding the electrospinning jet adversely affects the electrospinning process. When the ambient pressure drops below atmospheric pressure, the polymer solution in the syringe will have a greater tendency to flow through the needle, resulting in an unstable spray start. As the pressure decreases, rapid solution foaming occurs at the needle tip. At very low pressure, electrospinning is not possible due to the direct discharge of electric charges [1].
Reasons such as health problems, population density, environmental pollution, and increased consumption have encouraged people to seek natural solutions. The use of herbal products in the field of health for their healing properties is increasing day by day. In recent years, plants derived from natural substances such as flavonoids, terpenoids, steroids have received considerable attention due to their different pharmacological properties, including antibacterial, antioxidant, and anticancer activity.
The olive leaf plant, which draws attention with its biocompatible, biodegradable, antioxidant, and antimicrobial properties, has been used by many researchers [24, 25, 26, 27] in the electrospinning process for use in the biomedical field. Similarly, because of its biocompatible, biodegradable and antimicrobial properties, and rosemary plant [28, 29] has been used as a bioactive packaging material and to obtain nanofibers by electrospinning for use in the biomedical field. Many plant extracts such as aloe vera [30, 31], thyme [10], grape seed [32], chamomile [33], green tea [34], grewia mollis [35], gotu kola [36], calendula [37], mangosteen [38], lavender [39] are mixed with different polymers and used in the production of nanofibers for use in the medical field.
The fact that different plants grow in every geography, each plant has different and many effects and the ability to obtain biocompatible, sustainable, organic, and environmentally friendly products have encouraged researchers to work in this field. The use of plants obtained from natural sources as active agents is increasing day by day in areas such as wound healing, tissue engineering, and drug release.
The skin forms the largest part of body weight and is very vulnerable to external forces and effects such as tissue traumas and injuries. Today, wound dressings play a vital role in the healing of such wounds, and wound healing depends on several factors such as selection of wound dressing, physiological state of the wound, and degree of damage. An ideal wound dressing should facilitate wound healing, remove exudates from the wound bed, be non-toxic and allergenic, and act as a barrier against microbes [4, 30]. Conventional wound dressings are generally used to close the wound and absorb the excess discharge. Although in previous studies, it was stated that the dressing should keep the wound dry, it is known that a warm and moist environment on the wound increases the healing of the wound [40]. However, it is a fact that excessive moisture causes wetting and softening of the scar tissues and prolongs the wound healing process [4]. Keeping the humidity level at an optimum level is very important for wound treatment. In addition to the ideal moisture level of modern wound dressings, effective oxygen circulation, air permeability, and low bacterial contamination are the essential qualities sought [40].
Modern wound dressings are composed of water-absorbent granular hydrocolloids, alginate containing mannuronic and guluronic acids, and hydrogel, in which water-absorbing polymers are structured into a three-dimensional network [40]. In recent years, with the rapid development of tissue engineering, nanofiber-based ECM (extracellular matrix) scaffold structures have become widespread [4]. ECM is a collagenous substance commonly found in skin, tendons, cartilage, and bone [11]. Compared to other wound dressings, nanofiber wound dressings have advantages such as hemostasis, high porosity, good fluid absorption capacity, small pore sizes, and large surface area [4]. Hyaluronic acid, collagen, chitosan-based nanofibers are generally used in new generation nanofiber-containing bioactive wound dressings due to their biocompatible, biodegradable, and antibacterial properties [40]. Thus, it ensures the healing of the wound by releasing the active substance in the nanofiber structure onto the wound in a controlled manner.
In recent studies [24, 29, 41, 42, 43], herbal extracts seem to be helpful in fighting infection and accelerating the wound healing process. The use of herbal extracts as wound dressings can nourish the wound site with healing properties such as antimicrobial, anti-inflammatory, analgesic, and tissue regeneration [30]. The long-term toxicity and harmful side effects of herbal extracts are generally insignificant compared to synthetic drugs. The main disadvantage of herbal medicines is that they need to be used in higher dosages than synthetic medicines. Large amounts of herbal medicines extracted from plants reduce their solubility in water or other chemical solvents. Therefore, dissolution of plant extracts almost never occurs in polymer-carriers such as capsules, nanofiber mats, and casting films containing herbal medicines. This may cause adverse effects in applications such as drug release behavior. Despite these problems, herbal drugs promise great success compared to chemical drugs due to their superior performance in wound treatments [10]. The important point here is to extract the herbal extracts in a suitable solvent, to obtain a biocompatible polymer and a nanofibrous structure that preserves its existing effects such as anti-inflammatory and antibacterial and supports the repair of opened wounds.
Tissue engineering is a field that aims to heal damaged or diseased tissues/organs, to maintain, regenerate and develop the functions of normal tissues/organs, and to form tissue scaffolds with repair capability for this purpose. Electrospinning is an application with high potential in many tissue engineering fields such as vasculature, bone, neural, and tendon/ligament. With the electrospinning process, the ability to form aligned scaffolds for anisotropic mechanical and biological properties in the field of vascular grafts, as well as the ability to inhibit smooth muscle cell migration, is provided. In addition, possibilities have been presented to improve vascular grafts with tissue scaffolds that can be obtained by tissue engineering [5, 44].
Nanofibers in tissue engineering must have such as biocompatible, biodegradable (with an acceptable shelf life), tissue-appropriate degradation rate, tissue-appropriate mechanical (strength, stiffness, and modulus) and structural (pore sizes, shape, and structure) properties, and sterilizability [45]. Tissues consist of multiple cell types and works in conjunction with the cell-surrounding extracellular matrix (ECM), which is the tissue scaffold, concealed by regular, micro-sized cells. The ECM is responsible for providing the cells with the needed mechanical support and protecting the cells. The materials used in tissue engineering applications should allow a certain interaction with the cell, the cell’s attachment, proliferation, change, ECM production, and proper progression of this process should be ensured. It should form a supporting function in the formation of new tissues [3, 44].
Approximately, 25% of current prescription drugs are derived from trees, medicinal plants, shrubs, and herbs in nature. The use of herbal extracts with nanofibers produced by electrospinning provides a good potential to form scaffolds for skin regeneration [46]. For example, it has been seen that the nanofibrous structure of the chamomile plant supports collagen fiber accumulation and tissue formation in the dermis [33], and the olive leaf plant has a good potential for tissue scaffolding in biomedical applications thanks to its high antioxidant effect [3]. There are studies on tissue scaffolds containing edible, non-toxic, biocompatible, biodegradable plant extracts with many different contents. It is thought that the applications of plant-based tissue scaffolds will increase in future studies.
Drug delivery systems aim to deliver the drug to the unhealthy region in a controlled and regular manner and to ensure its effectiveness in this region. While drug delivery is generally associated with the delivery of therapeutic agents for the treatment of certain disease states such as cancer, the delivery systems for tissue engineering applications can also apply to the delivery of bioactive agents such as proteins and DNA [5].
In conventional drug delivery systems, successive doses of the drug cause a fluctuating profile of the drug concentration in the blood throughout the treatment period. Therefore, at certain times, concentrations may exceed the recommended maximum (Cmax) concentration with the risk of biotoxicity or fall below the minimum concentration (Cmin), limiting the therapeutic effect. To obtain the highest therapeutic value from the drug, the optimum concentration (C), (Cmin < C < Cmax) in body tissue should be maintained throughout the entire treatment period. Via controlled delivery techniques, the bioavailability of the drug has been designed throughout to be close to this optimum value. In addition, the amount of drug required to be administered is relatively lower in the controlled release mode, minimizing potential side effects [6].
In tissue engineering, the design of the polymer scaffold requires the release of growth factors and other bioactive substances into the growing tissue over a period of time. In nanofiber applications such as wound dressings or artificial leather, the local controlled release of antibiotic substances can aid the healing process. Polymer-based delivery systems can produce controlled drug release by diffusion or chemical bioerosion of the matrix or biodegradation of the linkages connecting the drug to the matrix [6]. These advantages are of great importance in their preference and use.
Polymer-based drug delivery systems; nano or microparticles, hydrogels, micelles, and fibrillar systems. Fibrillated systems form nanofiber-based drug release systems [3]. The release kinetics of the drug is controlled by the morphology of the polymer/drug composite as well as the semi-crystalline structure of the polymer. First, the drug is dissolved at the molecular level in the polymer matrix. The drug is separated as crystalline or amorphous particles in the polymer matrix [6, 47].
The use of herbal-based nanofiber structures in drug delivery systems has increased in recent years. There are different applications such as designing coaxial nanofibers by using olive leaf extract as a bioactive agent [25], producing nanofiber membranes containing aloe vera [48], using nanofibers prepared using the bark of Tecomella undulate (rohida) plant in in-vitro drug release [49]. It is expected that nanofiber drug delivery systems containing herbal extracts will increase therapeutic efficacy, reduce toxicity and ensure compatibility with patients by delivering drugs to the affected area at a controlled rate for a certain period.
Electrospinning is a nanofiber production method that is the most preferred because it is simple, economical, and environmentally friendly, and has many production parameters including solution, process, and environmental conditions. Production of nanofibers by electrospinning process; It is a subject that draws attention with its applications in many fields such as tissue engineering, drug release, filtration, automotive, energy, food industry, cosmetics, agriculture, biosensing. Although polymer contents with synthetic infrastructures are generally preferred in these applications, approaches to using natural agents with few side effects, biocompatible, sustainable, economical, biodegradable, and free from toxic components are increasing [10, 27, 33, 41, 42]. The use of natural components containing active agents in the production of nanofibers is becoming more and more common in the fight against potential health problems that may occur due to the rapidly increasing world population and environmental pollution. Herbal extracts are promising in electrospinning applications with their biodiversity, ability to maintain their biological functionality even after exposure to high electrical voltage, and wound healing effects against pathogenic microorganisms. In addition, it is thought that the use of herbal extracts in different applications in the field of health will become widespread, as they have fewer side effects, and versatile therapeutic properties compared to chemical agents.
The authors declare no conflict of interest.
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This work allows analyzing the optical flow over small regions in an optimal way in relation to precision (and computational cost), enabling its application to area, such as cardiology, in the prediction of infarction.",book:{id:"10652",title:"Information Extraction and Object Tracking in Digital Video",coverURL:"https://cdn.intechopen.com/books/images_new/10652.jpg"},signatures:"Ronaldo Ferreira, Joaquim José de Castro Ferreira and António José Ribeiro Neves"},{id:"81558",title:"Thresholding Image Techniques for Plant Segmentation",slug:"thresholding-image-techniques-for-plant-segmentation",totalDownloads:20,totalDimensionsCites:0,doi:"10.5772/intechopen.104587",abstract:"There are challenges in the image-based research to obtain information from the objects in the scene. Moreover, an image is a set of data points that can be processed as an object in similarity way. In addition, the research fields can be merged to generate a method for information extraction and pixel classification. A complete method is proposed to extract information from the data and generate a classification model capable to isolate those pixels that are plant from others are not. Some quantitative and qualitative results are shown to compare methods to extract information and create the best model. Classical and threshold-based state-of-art methods are grouped in the present work for reference and application in image segmentation, obtaining acceptable results in the plant isolation.",book:{id:"10652",title:"Information Extraction and Object Tracking in Digital Video",coverURL:"https://cdn.intechopen.com/books/images_new/10652.jpg"},signatures:"Miguel Ángel Castillo-Martínez, Francisco Javier Gallegos-Funes, Blanca E. Carvajal-Gámez, Guillermo Urriolagoitia-Sosa and Alberto J. Rosales-Silva"},{id:"81234",title:"Cognitive Visual Tracking of Hand Gestures in Real-Time RGB Videos",slug:"cognitive-visual-tracking-of-hand-gestures-in-real-time-rgb-videos",totalDownloads:40,totalDimensionsCites:0,doi:"10.5772/intechopen.103170",abstract:"Real-time visual hand tracking is quite different from commonly tracked objects in RGB videos. Because the hand is a biological object and hence suffers from both physical and behavioral variations during its movement. Furthermore, the hand acquires a very small area in the image frame, and due to its erratic pattern of movement, the quality of images in the video is affected considerably, if recorded from a simple RGB camera. In this chapter, we propose a hybrid framework to track the hand movement in RGB video sequences. The framework integrates the unique features of the Faster Region-based Convolutional Neural Network (Faster R-CNN) built on Residual Network and Scale-Invariant Feature Transform (SIFT) algorithm. This combination is enriched with the discriminative learning power of deep neural networks and the fast detection capability of hand-crafted features SIFT. Thus, our method online adapts the variations occurring in real-time hand movement and exhibits high efficiency in cognitive recognition of hand trajectory. The empirical results shown in the chapter demonstrate that the approach can withstand the intrinsic as well as extrinsic challenges associated with visual tracking of hand gestures in RGB videos.",book:{id:"10652",title:"Information Extraction and Object Tracking in Digital Video",coverURL:"https://cdn.intechopen.com/books/images_new/10652.jpg"},signatures:"Richa Golash and Yogendra Kumar Jain"},{id:"80064",title:"Robust Template Update Strategy for Efficient Visual Object Tracking",slug:"robust-template-update-strategy-for-efficient-visual-object-tracking",totalDownloads:64,totalDimensionsCites:0,doi:"10.5772/intechopen.101800",abstract:"Real-time visual object tracking is an open problem in computer vision, with multiple applications in the industry, such as autonomous vehicles, human-machine interaction, intelligent cinematography, automated surveillance, and autonomous social navigation. The challenge of tracking a target of interest is critical to all of these applications. Recently, tracking algorithms that use siamese neural networks trained offline on large-scale datasets of image pairs have achieved the best performance exceeding real-time speed on multiple benchmarks. Results show that siamese approaches can be applied to enhance the tracking capabilities by learning deeper features of the object’s appearance. SiamMask utilized the power of siamese networks and supervised learning approaches to solve the problem of arbitrary object tracking in real-time speed. However, its practical applications are limited due to failures encountered during testing. In order to improve the robustness of the tracker and make it applicable for the intended real-world application, two improvements have been incorporated, each addressing a different aspect of the tracking task. The first one is a data augmentation strategy to consider both motion-blur and low-resolution during training. It aims to increase the robustness of the tracker against a motion-blurred and low-resolution frames during inference. The second improvement is a target template update strategy that utilizes both the initial ground truth template and a supplementary updatable template, which considers the score of the predicted target for an efficient template update strategy by avoiding template updates during severe occlusion. All of the improvements were extensively evaluated and have achieved state-of-the-art performance in the VOT2018 and VOT2019 benchmarks. Our method (VPU-SiamM) has been submitted to the VOT-ST 2020 challenge, and it is ranked 16th out of 38 submitted tracking methods according to the Expected average overlap (EAO) metrics. VPU_SiamM Implementation can be found from the VOT2020 Trackers repository1.",book:{id:"10652",title:"Information Extraction and Object Tracking in Digital Video",coverURL:"https://cdn.intechopen.com/books/images_new/10652.jpg"},signatures:"Awet Haileslassie Gebrehiwot, Jesus Bescos and Alvaro Garcia-Martin"},{id:"80109",title:"Siamese-Based Attention Learning Networks for Robust Visual Object Tracking",slug:"siamese-based-attention-learning-networks-for-robust-visual-object-tracking",totalDownloads:101,totalDimensionsCites:0,doi:"10.5772/intechopen.101698",abstract:"Tracking with the siamese network has recently gained enormous popularity in visual object tracking by using the template-matching mechanism. However, using only the template-matching process is susceptible to robust target tracking because of its inability to learn better discrimination between target and background. Several attention-learning are introduced to the underlying siamese network to enhance the target feature representation, which helps to improve the discrimination ability of the tracking framework. The attention mechanism is beneficial for focusing on the particular target feature by utilizing relevant weight gain. This chapter presents an in-depth overview and analysis of attention learning-based siamese trackers. We also perform extensive experiments to compare state-of-the-art methods. Furthermore, we also summarize our study by highlighting the key findings to provide insights into future visual object tracking developments.",book:{id:"10652",title:"Information Extraction and Object Tracking in Digital Video",coverURL:"https://cdn.intechopen.com/books/images_new/10652.jpg"},signatures:"Md. Maklachur Rahman and Soon Ki Jung"},{id:"79005",title:"Smart-Road: Road Damage Estimation Using a Mobile Device",slug:"smart-road-road-damage-estimation-using-a-mobile-device",totalDownloads:120,totalDimensionsCites:0,doi:"10.5772/intechopen.100289",abstract:"Mexico is located on five tectonic plates, which when moving, generate telluric movements. These movements, depending on their intensity, affect the telecommunications infrastructure. Earthquakes tend to cause landslides, subsidence, damage to structures in houses, buildings, and roads. In the case of road damage, it is reflected in cracks in the pavement, which are classified according to their size, shape, and depth. The methods that are currently implemented to inspect roads mainly use human perception and are limited to a superficial inspection of the terrain, causing this process ineffective for the timely detection of damage. This work presents a method of road analysis using a drone to acquire images. For the processing and recognition of damages, a mobile device is used, allowing to determine the damage type on the road. Artificial intelligence techniques are implemented to classify them into linear cracks or zig-zag cracks.",book:{id:"10652",title:"Information Extraction and Object Tracking in Digital Video",coverURL:"https://cdn.intechopen.com/books/images_new/10652.jpg"},signatures:"Izyalith E. Álvarez-Cisneros, Blanca E. Carvajal-Gámez, David Araujo-Díaz, Miguel A. Castillo-Martínez and L. Méndez-Segundo"}],onlineFirstChaptersTotal:8},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:89,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:32,numberOfPublishedChapters:318,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:106,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:5,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:15,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. This Biochemistry Series will address the current research on biomolecules and the emerging trends with great promise.",coverUrl:"https://cdn.intechopen.com/series/covers/11.jpg",latestPublicationDate:"June 29th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:32,editor:{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",slug:"miroslav-blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"14",title:"Cell and Molecular Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",isOpenForSubmission:!0,editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",slug:"rosa-maria-martinez-espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",biography:"Dr. Rosa María Martínez-Espinosa has been a Spanish Full Professor since 2020 (Biochemistry and Molecular Biology) and is currently Vice-President of International Relations and Cooperation development and leader of the research group 'Applied Biochemistry” (University of Alicante, Spain). Other positions she has held at the university include Vice-Dean of Master Programs, Vice-Dean of the Degree in Biology and Vice-Dean for Mobility and Enterprise and Engagement at the Faculty of Science (University of Alicante). She received her Bachelor in Biology in 1998 (University of Alicante) and her PhD in 2003 (Biochemistry, University of Alicante). She undertook post-doctoral research at the University of East Anglia (Norwich, U.K. 2004-2005; 2007-2008).\nHer multidisciplinary research focuses on investigating archaea and their potential applications in biotechnology. She has an H-index of 21. She has authored one patent and has published more than 70 indexed papers and around 60 book chapters.\nShe has contributed to more than 150 national and international meetings during the last 15 years. Her research interests include archaea metabolism, enzymes purification and characterization, gene regulation, carotenoids and bioplastics production, antioxidant\ncompounds, waste water treatments, and brines bioremediation.\nRosa María’s other roles include editorial board member for several journals related\nto biochemistry, reviewer for more than 60 journals (biochemistry, molecular biology, biotechnology, chemistry and microbiology) and president of several organizing committees in international meetings related to the N-cycle or respiratory processes.",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"15",title:"Chemical Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",isOpenForSubmission:!0,editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",slug:"sukru-beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",biography:"Dr. Şükrü Beydemir obtained a BSc in Chemistry in 1995 from Yüzüncü Yıl University, MSc in Biochemistry in 1998, and PhD in Biochemistry in 2002 from Atatürk University, Turkey. He performed post-doctoral studies at Max-Planck Institute, Germany, and University of Florence, Italy in addition to making several scientific visits abroad. He currently works as a Full Professor of Biochemistry in the Faculty of Pharmacy, Anadolu University, Turkey. Dr. Beydemir has published over a hundred scientific papers spanning protein biochemistry, enzymology and medicinal chemistry, reviews, book chapters and presented several conferences to scientists worldwide. He has received numerous publication awards from various international scientific councils. He serves in the Editorial Board of several international journals. Dr. Beydemir is also Rector of Bilecik Şeyh Edebali University, Turkey.",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",slug:"deniz-ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",biography:"Dr. Deniz Ekinci obtained a BSc in Chemistry in 2004, MSc in Biochemistry in 2006, and PhD in Biochemistry in 2009 from Atatürk University, Turkey. He studied at Stetson University, USA, in 2007-2008 and at the Max Planck Institute of Molecular Cell Biology and Genetics, Germany, in 2009-2010. Dr. Ekinci currently works as a Full Professor of Biochemistry in the Faculty of Agriculture and is the Head of the Enzyme and Microbial Biotechnology Division, Ondokuz Mayıs University, Turkey. He is a member of the Turkish Biochemical Society, American Chemical Society, and German Genetics society. Dr. Ekinci published around ninety scientific papers, reviews and book chapters, and presented several conferences to scientists. He has received numerous publication awards from several scientific councils. Dr. Ekinci serves as the Editor in Chief of four international books and is involved in the Editorial Board of several international journals.",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null},{id:"17",title:"Metabolism",coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",isOpenForSubmission:!0,editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",slug:"yannis-karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",biography:"Yannis Karamanos, born in Greece in 1953, completed his pre-graduate studies at the Université Pierre et Marie Curie, Paris, then his Masters and Doctoral degree at the Université de Lille (1983). He was associate professor at the University of Limoges (1987) before becoming full professor of biochemistry at the Université d’Artois (1996). He worked on the structure-function relationships of glycoconjugates and his main project was the investigations on the biological roles of the de-N-glycosylation enzymes (Endo-N-acetyl-β-D-glucosaminidase and peptide-N4-(N-acetyl-β-glucosaminyl) asparagine amidase). From 2002 he contributes to the understanding of the Blood-brain barrier functioning using proteomics approaches. He has published more than 70 papers. His teaching areas are energy metabolism and regulation, integration and organ specialization and metabolic adaptation.",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null},{id:"18",title:"Proteomics",coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",isOpenForSubmission:!0,editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",slug:"paolo-iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",biography:"Paolo Iadarola graduated with a degree in Chemistry from the University of Pavia (Italy) in July 1972. He then worked as an Assistant Professor at the Faculty of Science of the same University until 1984. In 1985, Prof. Iadarola became Associate Professor at the Department of Biology and Biotechnologies of the University of Pavia and retired in October 2017. Since then, he has been working as an Adjunct Professor in the same Department at the University of Pavia. His research activity during the first years was primarily focused on the purification and structural characterization of enzymes from animal and plant sources. During this period, Prof. Iadarola familiarized himself with the conventional techniques used in column chromatography, spectrophotometry, manual Edman degradation, and electrophoresis). Since 1995, he has been working on: i) the determination in biological fluids (serum, urine, bronchoalveolar lavage, sputum) of proteolytic activities involved in the degradation processes of connective tissue matrix, and ii) on the identification of biological markers of lung diseases. In this context, he has developed and validated new methodologies (e.g., Capillary Electrophoresis coupled to Laser-Induced Fluorescence, CE-LIF) whose application enabled him to determine both the amounts of biochemical markers (Desmosines) in urine/serum of patients affected by Chronic Obstructive Pulmonary Disease (COPD) and the activity of proteolytic enzymes (Human Neutrophil Elastase, Cathepsin G, Pseudomonas aeruginosa elastase) in sputa of these patients. More recently, Prof. Iadarola was involved in developing techniques such as two-dimensional electrophoresis coupled to liquid chromatography/mass spectrometry (2DE-LC/MS) for the proteomic analysis of biological fluids aimed at the identification of potential biomarkers of different lung diseases. He is the author of about 150 publications (According to Scopus: H-Index: 23; Total citations: 1568- According to WOS: H-Index: 20; Total Citations: 1296) of peer-reviewed international journals. He is a Consultant Reviewer for several journals, including the Journal of Chromatography A, Journal of Chromatography B, Plos ONE, Proteomes, International Journal of Molecular Science, Biotech, Electrophoresis, and others. He is also Associate Editor of Biotech.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",slug:"simona-viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",biography:"Simona Viglio is an Associate Professor of Biochemistry at the Department of Molecular Medicine at the University of Pavia. She has been working since 1995 on the determination of proteolytic enzymes involved in the degradation process of connective tissue matrix and on the identification of biological markers of lung diseases. She gained considerable experience in developing and validating new methodologies whose applications allowed her to determine both the amount of biomarkers (Desmosine and Isodesmosine) in the urine of patients affected by COPD, and the activity of proteolytic enzymes (HNE, Cathepsin G, Pseudomonas aeruginosa elastase) in the sputa of these patients. Simona Viglio was also involved in research dealing with the supplementation of amino acids in patients with brain injury and chronic heart failure. She is presently engaged in the development of 2-DE and LC-MS techniques for the study of proteomics in biological fluids. The aim of this research is the identification of potential biomarkers of lung diseases. She is an author of about 90 publications (According to Scopus: H-Index: 23; According to WOS: H-Index: 20) on peer-reviewed journals, a member of the “Società Italiana di Biochimica e Biologia Molecolare,“ and a Consultant Reviewer for International Journal of Molecular Science, Journal of Chromatography A, COPD, Plos ONE and Nutritional Neuroscience.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null}]},overviewPageOFChapters:{paginationCount:36,paginationItems:[{id:"82195",title:"Endoplasmic Reticulum: A Hub in Lipid Homeostasis",doi:"10.5772/intechopen.105450",signatures:"Raúl Ventura and María Isabel Hernández-Alvarez",slug:"endoplasmic-reticulum-a-hub-in-lipid-homeostasis",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Updates on Endoplasmic Reticulum",coverURL:"https://cdn.intechopen.com/books/images_new/11674.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"82409",title:"Purinergic Signaling in Covid-19 Disease",doi:"10.5772/intechopen.105008",signatures:"Hailian Shen",slug:"purinergic-signaling-in-covid-19-disease",totalDownloads:5,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Purinergic System",coverURL:"https://cdn.intechopen.com/books/images_new/10801.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"82374",title:"The Potential of the Purinergic System as a Therapeutic Target of Natural Compounds in Cutaneous Melanoma",doi:"10.5772/intechopen.105457",signatures:"Gilnei Bruno da Silva, Daiane Manica, Marcelo Moreno and Margarete Dulce Bagatini",slug:"the-potential-of-the-purinergic-system-as-a-therapeutic-target-of-natural-compounds-in-cutaneous-mel",totalDownloads:10,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Purinergic System",coverURL:"https://cdn.intechopen.com/books/images_new/10801.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"82103",title:"The Role of Endoplasmic Reticulum Stress and Its Regulation in the Progression of Neurological and Infectious Diseases",doi:"10.5772/intechopen.105543",signatures:"Mary Dover, Michael Kishek, Miranda Eddins, Naneeta Desar, Ketema Paul and Milan Fiala",slug:"the-role-of-endoplasmic-reticulum-stress-and-its-regulation-in-the-progression-of-neurological-and-i",totalDownloads:6,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Updates on Endoplasmic Reticulum",coverURL:"https://cdn.intechopen.com/books/images_new/11674.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}}]},overviewPagePublishedBooks:{paginationCount:32,paginationItems:[{type:"book",id:"7006",title:"Biochemistry and Health Benefits of Fatty Acids",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7006.jpg",slug:"biochemistry-and-health-benefits-of-fatty-acids",publishedDate:"December 19th 2018",editedByType:"Edited by",bookSignature:"Viduranga Waisundara",hash:"c93a00abd68b5eba67e5e719f67fd20b",volumeInSeries:1,fullTitle:"Biochemistry and Health Benefits of Fatty Acids",editors:[{id:"194281",title:"Dr.",name:"Viduranga Y.",middleName:null,surname:"Waisundara",slug:"viduranga-y.-waisundara",fullName:"Viduranga Y. 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He received his Ph.D. in Molecular Biology with his thesis “Genetic variability of the tick-borne encephalitis virus in natural foci of Novosibirsk city and its suburbs.” His primary field is molecular virology with research emphasis on vector-borne viruses, especially tick-borne encephalitis virus, Kemerovo virus and Omsk hemorrhagic fever virus, rabies virus, molecular genetics, biology, and epidemiology of virus pathogens.",institutionString:"Russian Academy of Sciences",institution:{name:"Russian Academy of Sciences",country:{name:"Russia"}}},{id:"310962",title:"Dr.",name:"Amlan",middleName:"Kumar",surname:"Patra",slug:"amlan-patra",fullName:"Amlan Patra",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/310962/images/system/310962.jpg",biography:"Amlan K. Patra, FRSB, obtained a Ph.D. in Animal Nutrition from Indian Veterinary Research Institute, India, in 2002. He is currently an associate professor at West Bengal University of Animal and Fishery Sciences. He has more than twenty years of research and teaching experience. He held previous positions at the American Institute for Goat Research, The Ohio State University, Columbus, USA, and Free University of Berlin, Germany. His research focuses on animal nutrition, particularly ruminants and poultry nutrition, gastrointestinal electrophysiology, meta-analysis and modeling in nutrition, and livestock–environment interaction. He has authored around 175 articles in journals, book chapters, and proceedings. Dr. Patra serves on the editorial boards of several reputed journals.",institutionString:null,institution:{name:"West Bengal University of Animal and Fishery Sciences",country:{name:"India"}}},{id:"53998",title:"Prof.",name:"László",middleName:null,surname:"Babinszky",slug:"laszlo-babinszky",fullName:"László Babinszky",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/53998/images/system/53998.png",biography:"László Babinszky is Professor Emeritus, Department of Animal Nutrition Physiology, University of Debrecen, Hungary. He has also worked in the Department of Animal Nutrition, University of Wageningen, Netherlands; the Institute for Livestock Feeding and Nutrition (IVVO), Lelystad, Netherlands; the Agricultural University of Vienna (BOKU); the Institute for Animal Breeding and Nutrition, Austria; and the Oscar Kellner Research Institute for Animal Nutrition, Rostock, Germany. In 1992, Dr. Babinszky obtained a Ph.D. in Animal Nutrition from the University of Wageningen. His main research areas are swine and poultry nutrition. He has authored more than 300 publications (papers, book chapters) and edited four books and fourteen international conference proceedings.",institutionString:"University of Debrecen",institution:{name:"University of Debrecen",country:{name:"Hungary"}}},{id:"201830",title:"Dr.",name:"Fernando",middleName:"Sanchez",surname:"Davila",slug:"fernando-davila",fullName:"Fernando Davila",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/201830/images/5017_n.jpg",biography:"I am a professor at UANL since 1988. My research lines are the development of reproductive techniques in small ruminants. We also conducted research on sexual and social behavior in males.\nI am Mexican and study my professional career as an engineer in agriculture and animal science at UANL. Then take a masters degree in science in Germany (Animal breeding). Take a doctorate in animal science at the UANL.",institutionString:null,institution:{name:"Universidad Autónoma de Nuevo León",country:{name:"Mexico"}}},{id:"309250",title:"Dr.",name:"Miguel",middleName:null,surname:"Quaresma",slug:"miguel-quaresma",fullName:"Miguel Quaresma",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/309250/images/9059_n.jpg",biography:"Miguel Nuno Pinheiro Quaresma was born on May 26, 1974 in Dili, Timor Island. He is married with two children: a boy and a girl, and he is a resident in Vila Real, Portugal. He graduated in Veterinary Medicine in August 1998 and obtained his Ph.D. degree in Veterinary Sciences -Clinical Area in February 2015, both from the University of Trás-os-Montes e Alto Douro. He is currently enrolled in the Alternative Residency of the European College of Animal Reproduction. He works as a Senior Clinician at the Veterinary Teaching Hospital of UTAD (HVUTAD) with a role in clinical activity in the area of livestock and equine species as well as to support teaching and research in related areas. He teaches as an Invited Professor in Reproduction Medicine I and II of the Master\\'s in Veterinary Medicine degree at UTAD. Currently, he holds the position of Chairman of the Portuguese Buiatrics Association. He is a member of the Consultive Group on Production Animals of the OMV. He has 19 publications in indexed international journals (ISIS), as well as over 60 publications and oral presentations in both Portuguese and international journals and congresses.",institutionString:"University of Trás-os-Montes and Alto Douro",institution:{name:"University of Trás-os-Montes and Alto Douro",country:{name:"Portugal"}}},{id:"38652",title:"Prof.",name:"Rita",middleName:null,surname:"Payan-Carreira",slug:"rita-payan-carreira",fullName:"Rita Payan-Carreira",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRiFPQA0/Profile_Picture_1614601496313",biography:"Rita Payan Carreira earned her Veterinary Degree from the Faculty of Veterinary Medicine in Lisbon, Portugal, in 1985. She obtained her Ph.D. in Veterinary Sciences from the University of Trás-os-Montes e Alto Douro, Portugal. After almost 32 years of teaching at the University of Trás-os-Montes and Alto Douro, she recently moved to the University of Évora, Department of Veterinary Medicine, where she teaches in the field of Animal Reproduction and Clinics. Her primary research areas include the molecular markers of the endometrial cycle and the embryo–maternal interaction, including oxidative stress and the reproductive physiology and disorders of sexual development, besides the molecular determinants of male and female fertility. She often supervises students preparing their master's or doctoral theses. She is also a frequent referee for various journals.",institutionString:null,institution:{name:"University of Évora",country:{name:"Portugal"}}},{id:"283019",title:"Dr.",name:"Oudessa",middleName:null,surname:"Kerro Dego",slug:"oudessa-kerro-dego",fullName:"Oudessa Kerro Dego",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/283019/images/system/283019.png",biography:"Dr. Kerro Dego is a veterinary microbiologist with training in veterinary medicine, microbiology, and anatomic pathology. Dr. Kerro Dego is an assistant professor of dairy health in the department of animal science, the University of Tennessee, Institute of Agriculture, Knoxville, Tennessee. He received his D.V.M. (1997), M.S. (2002), and Ph.D. (2008) degrees in Veterinary Medicine, Animal Pathology and Veterinary Microbiology from College of Veterinary Medicine, Addis Ababa University, Ethiopia; College of Veterinary Medicine, Utrecht University, the Netherlands and Western College of Veterinary Medicine, University of Saskatchewan, Canada respectively. He did his Postdoctoral training in microbial pathogenesis (2009 - 2015) in the Department of Animal Science, the University of Tennessee, Institute of Agriculture, Knoxville, Tennessee. Dr. Kerro Dego’s research focuses on the prevention and control of infectious diseases of farm animals, particularly mastitis, improving dairy food safety, and mitigation of antimicrobial resistance. Dr. Kerro Dego has extensive experience in studying the pathogenesis of bacterial infections, identification of virulence factors, and vaccine development and efficacy testing against major bacterial mastitis pathogens. Dr. Kerro Dego conducted numerous controlled experimental and field vaccine efficacy studies, vaccination, and evaluation of immunological responses in several species of animals, including rodents (mice) and large animals (bovine and ovine).",institutionString:"University of Tennessee at Knoxville",institution:{name:"University of Tennessee at Knoxville",country:{name:"United States of America"}}},{id:"251314",title:"Dr.",name:"Juan Carlos",middleName:null,surname:"Gardón",slug:"juan-carlos-gardon",fullName:"Juan Carlos Gardón",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/251314/images/system/251314.jpeg",biography:"Juan Carlos Gardón Poggi received University degree from the Faculty of Agrarian Science in Argentina, in 1983. Also he received Masters Degree and PhD from Córdoba University, Spain. He is currently a Professor at the Catholic University of Valencia San Vicente Mártir, at the Department of Medicine and Animal Surgery. He teaches diverse courses in the field of Animal Reproduction and he is the Director of the Veterinary Farm. He also participates in academic postgraduate activities at the Veterinary Faculty of Murcia University, Spain. His research areas include animal physiology, physiology and biotechnology of reproduction either in males or females, the study of gametes under in vitro conditions and the use of ultrasound as a complement to physiological studies and development of applied biotechnologies. Routinely, he supervises students preparing their doctoral, master thesis or final degree projects.",institutionString:"Catholic University of Valencia San Vicente Mártir, Spain",institution:null},{id:"125292",title:"Dr.",name:"Katy",middleName:null,surname:"Satué Ambrojo",slug:"katy-satue-ambrojo",fullName:"Katy Satué Ambrojo",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/125292/images/system/125292.jpeg",biography:"Katy Satué Ambrojo received her Veterinary Medicine degree, Master degree in Equine Technology and doctorate in Veterinary Medicine from the Faculty of Veterinary, CEU-Cardenal Herrera University in Valencia, Spain. She is a Full Professor at the Department of Medicine and Animal Surgery at the same University. She developed her research activity in the field of Endocrinology, Hematology, Biochemistry and Immunology of horses. She is a scientific reviewer of several international journals : American Journal of Obstetrics and Gynecology, Comparative Clinical Pathology, Veterinary Clinical Pathology, Journal of Equine Veterinary Science, Reproduction in Domestic Animals, Research Veterinary Science, Brazilian Journal of Medical and Biological Research, Livestock Production Science and Theriogenology. Since 2014, she has been the Head of the Clinical Analysis Laboratory of the Hospital Clínico Veterinario from the Faculty of Veterinary, CEU-Cardenal Herrera University.",institutionString:"CEU-Cardenal Herrera University",institution:{name:"CEU Cardinal Herrera University",country:{name:"Spain"}}},{id:"309529",title:"Dr.",name:"Albert",middleName:null,surname:"Rizvanov",slug:"albert-rizvanov",fullName:"Albert Rizvanov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/309529/images/9189_n.jpg",biography:'Albert A. Rizvanov is a Professor and Director of the Center for Precision and Regenerative Medicine at the Institute of Fundamental Medicine and Biology, Kazan Federal University (KFU), Russia. He is the Head of the Center of Excellence “Regenerative Medicine” and Vice-Director of Strategic Academic Unit \\"Translational 7P Medicine\\". Albert completed his Ph.D. at the University of Nevada, Reno, USA and Dr.Sci. at KFU. He is a corresponding member of the Tatarstan Academy of Sciences, Russian Federation. Albert is an author of more than 300 peer-reviewed journal articles and 22 patents. He has supervised 11 Ph.D. and 2 Dr.Sci. dissertations. Albert is the Head of the Dissertation Committee on Biochemistry, Microbiology, and Genetics at KFU.\nORCID https://orcid.org/0000-0002-9427-5739\nWebsite https://kpfu.ru/Albert.Rizvanov?p_lang=2',institutionString:"Kazan Federal University",institution:{name:"Kazan Federal University",country:{name:"Russia"}}},{id:"210551",title:"Dr.",name:"Arbab",middleName:null,surname:"Sikandar",slug:"arbab-sikandar",fullName:"Arbab Sikandar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/210551/images/system/210551.jpg",biography:"Dr. Arbab Sikandar, PhD, M. Phil, DVM was born on April 05, 1981. He is currently working at the College of Veterinary & Animal Sciences as an Assistant Professor. He previously worked as a lecturer at the same University. \nHe is a Member/Secretory of Ethics committee (No. CVAS-9377 dated 18-04-18), Member of the QEC committee CVAS, Jhang (Regr/Gen/69/873, dated 26-10-2017), Member, Board of studies of Department of Basic Sciences (No. CVAS. 2851 Dated. 12-04-13, and No. CVAS, 9024 dated 20/11/17), Member of Academic Committee, CVAS, Jhang (No. CVAS/2004, Dated, 25-08-12), Member of the technical committee (No. CVAS/ 4085, dated 20,03, 2010 till 2016).\n\nDr. Arbab Sikandar contributed in five days hands-on-training on Histopathology at the Department of Pathology, UVAS from 12-16 June 2017. He received a Certificate of appreciation for contributions for Popularization of Science and Technology in the Society on 17-11-15. He was the resource person in the lecture series- ‘scientific writing’ at the Department of Anatomy and Histology, UVAS, Lahore on 29th October 2015. He won a full fellowship as a principal candidate for the year 2015 in the field of Agriculture, EICA, Egypt with ref. to the Notification No. 12(11) ACS/Egypt/2014 from 10 July 2015 to 25th September 2015.; he received a grant of Rs. 55000/- as research incentives from Director, Advanced Studies and Research, UVAS, Lahore upon publications of research papers in IF Journals (DR/215, dated 19-5-2014.. He obtained his PhD by winning a HEC Pakistan indigenous Scholarship, ‘Ph.D. fellowship for 5000 scholars – Phase II’ (2av1-147), 17-6/HEC/HRD/IS-II/12, November 15, 2012. \n\nDr. Sikandar is a member of numerous societies: Registered Veterinary Medical Practitioner (life member) and Registered Veterinary Medical Faculty of Pakistan Veterinary Medical Council. The Registration code of PVMC is RVMP/4298 and RVMF/ 0102.; Life member of the University of Veterinary and Animal Sciences, Lahore, Alumni Association with S# 664, dated: 6-4-12. ; Member 'Vets Care Organization Pakistan” with Reference No. VCO-605-149, dated 05-04-06. :Member 'Vet Crescent” (Society of Animal Health and Production), UVAS, Lahore.",institutionString:"University of Veterinary & Animal Science",institution:{name:"University of Veterinary and Animal Sciences",country:{name:"Pakistan"}}},{id:"311663",title:"Dr.",name:"Prasanna",middleName:null,surname:"Pal",slug:"prasanna-pal",fullName:"Prasanna Pal",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/311663/images/13261_n.jpg",biography:null,institutionString:null,institution:{name:"National Dairy Research Institute",country:{name:"India"}}},{id:"202192",title:"Dr.",name:"Catrin",middleName:null,surname:"Rutland",slug:"catrin-rutland",fullName:"Catrin Rutland",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",biography:"Catrin Rutland is an Associate Professor of Anatomy and Developmental Genetics at the University of Nottingham, UK. She obtained a BSc from the University of Derby, England, a master’s degree from Technische Universität München, Germany, and a Ph.D. from the University of Nottingham. She undertook a post-doctoral research fellowship in the School of Medicine before accepting tenure in Veterinary Medicine and Science. Dr. Rutland also obtained an MMedSci (Medical Education) and a Postgraduate Certificate in Higher Education (PGCHE). She is the author of more than sixty peer-reviewed journal articles, twelve books/book chapters, and more than 100 research abstracts in cardiovascular biology and oncology. She is a board member of the European Association of Veterinary Anatomists, Fellow of the Anatomical Society, and Senior Fellow of the Higher Education Academy. Dr. Rutland has also written popular science books for the public. https://orcid.org/0000-0002-2009-4898. www.nottingham.ac.uk/vet/people/catrin.rutland",institutionString:null,institution:{name:"University of Nottingham",country:{name:"United Kingdom"}}},{id:"283315",title:"Prof.",name:"Samir",middleName:null,surname:"El-Gendy",slug:"samir-el-gendy",fullName:"Samir El-Gendy",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRduYQAS/Profile_Picture_1606215849748",biography:"Samir El-Gendy is a Professor of anatomy and embryology at the faculty of veterinary medicine, Alexandria University, Egypt. Samir obtained his PhD in veterinary science in 2007 from the faculty of veterinary medicine, Alexandria University and has been a professor since 2017. Samir is an author on 24 articles at Scopus and 12 articles within local journals and 2 books/book chapters. His research focuses on applied anatomy, imaging techniques and computed tomography. Samir worked as a member of different local projects on E-learning and he is a board member of the African Association of Veterinary Anatomists and of anatomy societies and as an associated author at local and international journals. Orcid: https://orcid.org/0000-0002-6180-389X",institutionString:null,institution:{name:"Alexandria University",country:{name:"Egypt"}}},{id:"246149",title:"Dr.",name:"Valentina",middleName:null,surname:"Kubale",slug:"valentina-kubale",fullName:"Valentina Kubale",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246149/images/system/246149.jpg",biography:"Valentina Kubale is Associate Professor of Veterinary Medicine at the Veterinary Faculty, University of Ljubljana, Slovenia. Since graduating from the Veterinary faculty she obtained her PhD in 2007, performed collaboration with the Department of Pharmacology, University of Copenhagen, Denmark. She continued as a post-doctoral fellow at the University of Copenhagen with a Lundbeck foundation fellowship. She is the editor of three books and author/coauthor of 23 articles in peer-reviewed scientific journals, 16 book chapters, and 68 communications at scientific congresses. Since 2008 she has been the Editor Assistant for the Slovenian Veterinary Research journal. She is a member of Slovenian Biochemical Society, The Endocrine Society, European Association of Veterinary Anatomists and Society for Laboratory Animals, where she is board member.",institutionString:"University of Ljubljana",institution:{name:"University of Ljubljana",country:{name:"Slovenia"}}},{id:"258334",title:"Dr.",name:"Carlos Eduardo",middleName:null,surname:"Fonseca-Alves",slug:"carlos-eduardo-fonseca-alves",fullName:"Carlos Eduardo Fonseca-Alves",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/258334/images/system/258334.jpg",biography:"Dr. Fonseca-Alves earned his DVM from Federal University of Goias – UFG in 2008. He completed an internship in small animal internal medicine at UPIS university in 2011, earned his MSc in 2013 and PhD in 2015 both in Veterinary Medicine at Sao Paulo State University – UNESP. Dr. Fonseca-Alves currently serves as an Assistant Professor at Paulista University – UNIP teaching small animal internal medicine.",institutionString:null,institution:{name:"Universidade Paulista",country:{name:"Brazil"}}},{id:"245306",title:"Dr.",name:"María Luz",middleName:null,surname:"Garcia Pardo",slug:"maria-luz-garcia-pardo",fullName:"María Luz Garcia Pardo",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/245306/images/system/245306.png",biography:"María de la Luz García Pardo is an agricultural engineer from Universitat Politècnica de València, Spain. She has a Ph.D. in Animal Genetics. Currently, she is a lecturer at the Agrofood Technology Department of Miguel Hernández University, Spain. Her research is focused on genetics and reproduction in rabbits. The major goal of her research is the genetics of litter size through novel methods such as selection by the environmental sensibility of litter size, with forays into the field of animal welfare by analysing the impact on the susceptibility to diseases and stress of the does. Details of her publications can be found at https://orcid.org/0000-0001-9504-8290.",institutionString:null,institution:{name:"Miguel Hernandez University",country:{name:"Spain"}}},{id:"350704",title:"M.Sc.",name:"Camila",middleName:"Silva Costa",surname:"Ferreira",slug:"camila-ferreira",fullName:"Camila Ferreira",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/350704/images/17280_n.jpg",biography:"Graduated in Veterinary Medicine at the Fluminense Federal University, specialist in Equine Reproduction at the Brazilian Veterinary Institute (IBVET) and Master in Clinical Veterinary Medicine and Animal Reproduction at the Fluminense Federal University. She has experience in analyzing zootechnical indices in dairy cattle and organizing events related to Veterinary Medicine through extension grants. I have experience in the field of diagnostic imaging and animal reproduction in veterinary medicine through monitoring and scientific initiation scholarships. I worked at the Equus Central Reproduction Equine located in Santo Antônio de Jesus – BA in the 2016/2017 breeding season. I am currently a doctoral student with a scholarship from CAPES of the Postgraduate Program in Veterinary Medicine (Pathology and Clinical Sciences) at the Federal Rural University of Rio de Janeiro (UFRRJ) with a research project with an emphasis on equine endometritis.",institutionString:null,institution:null},{id:"41319",title:"Prof.",name:"Lung-Kwang",middleName:null,surname:"Pan",slug:"lung-kwang-pan",fullName:"Lung-Kwang Pan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/41319/images/84_n.jpg",biography:null,institutionString:null,institution:null},{id:"201721",title:"Dr.",name:"Beatrice",middleName:null,surname:"Funiciello",slug:"beatrice-funiciello",fullName:"Beatrice Funiciello",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/201721/images/11089_n.jpg",biography:"Graduated from the University of Milan in 2011, my post-graduate education included CertAVP modules mainly on equines (dermatology and internal medicine) and a few on small animal (dermatology and anaesthesia) at the University of Liverpool. After a general CertAVP (2015) I gained the designated Certificate in Veterinary Dermatology (2017) after taking the synoptic examination and then applied for the RCVS ADvanced Practitioner status. After that, I completed the Postgraduate Diploma in Veterinary Professional Studies at the University of Liverpool (2018). My main area of work is cross-species veterinary dermatology.",institutionString:null,institution:null},{id:"291226",title:"Dr.",name:"Monica",middleName:null,surname:"Cassel",slug:"monica-cassel",fullName:"Monica Cassel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/291226/images/8232_n.jpg",biography:'Degree in Biological Sciences at the Federal University of Mato Grosso with scholarship for Scientific Initiation by FAPEMAT (2008/1) and CNPq (2008/2-2009/2): Project \\"Histological evidence of reproductive activity in lizards of the Manso region, Chapada dos Guimarães, Mato Grosso, Brazil\\". Master\\\'s degree in Ecology and Biodiversity Conservation at Federal University of Mato Grosso with a scholarship by CAPES/REUNI program: Project \\"Reproductive biology of Melanorivulus punctatus\\". PhD\\\'s degree in Science (Cell and Tissue Biology Area) \n at University of Sao Paulo with scholarship granted by FAPESP; Project \\"Development of morphofunctional changes in ovary of Astyanax altiparanae Garutti & Britski, 2000 (Teleostei, Characidae)\\". She has experience in Reproduction of vertebrates and Morphology, with emphasis in Cellular Biology and Histology. She is currently a teacher in the medium / technical level courses at IFMT-Alta Floresta, as well as in the Bachelor\\\'s degree in Animal Science and in the Bachelor\\\'s degree in Business.',institutionString:null,institution:null},{id:"442807",title:"Dr.",name:"Busani",middleName:null,surname:"Moyo",slug:"busani-moyo",fullName:"Busani Moyo",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Gwanda State University",country:{name:"Zimbabwe"}}},{id:"423023",title:"Dr.",name:"Yosra",middleName:null,surname:"Soltan",slug:"yosra-soltan",fullName:"Yosra Soltan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Alexandria University",country:{name:"Egypt"}}},{id:"349788",title:"Dr.",name:"Florencia Nery",middleName:null,surname:"Sompie",slug:"florencia-nery-sompie",fullName:"Florencia Nery Sompie",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Sam Ratulangi University",country:{name:"Indonesia"}}},{id:"208123",title:"Dr.",name:"Mari-Carmen",middleName:null,surname:"Uribe",slug:"mari-carmen-uribe",fullName:"Mari-Carmen Uribe",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"National Autonomous University of Mexico",country:{name:"Mexico"}}},{id:"345713",title:"Dr.",name:"Csaba",middleName:null,surname:"Szabó",slug:"csaba-szabo",fullName:"Csaba Szabó",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Debrecen",country:{name:"Hungary"}}},{id:"345719",title:"Mrs.",name:"Márta",middleName:null,surname:"Horváth",slug:"marta-horvath",fullName:"Márta Horváth",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Debrecen",country:{name:"Hungary"}}},{id:"420151",title:"Prof.",name:"Novirman",middleName:null,surname:"Jamarun",slug:"novirman-jamarun",fullName:"Novirman Jamarun",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Andalas University",country:{name:"Indonesia"}}}]}},subseries:{item:{id:"91",type:"subseries",title:"Sustainable Economy and Fair Society",keywords:"Sustainable, Society, Economy, Digitalization, KPIs, Decision Making, Business, Digital Footprint",scope:"\r\n\tGlobally, the ecological footprint is growing at a faster rate than GDP. This phenomenon has been studied by scientists for many years. However, clear strategies and actions are needed now more than ever. Every day, humanity, from individuals to businesses (public and private) and governments, are called to change their mindset in order to pursue a virtuous combination for sustainable development. Reasoning in a sustainable way entails, first and foremost, managing the available resources efficiently and strategically, whether they are natural, financial, human or relational. In this way, value is generated by contributing to the growth, improvement and socio-economic development of the communities and of all the players that make up its value chain. In the coming decades, we will need to be able to transition from a society in which economic well-being and health are measured by the growth of production and material consumption, to a society in which we live better while consuming less. In this context, digitization has the potential to disrupt processes, with significant implications for the environment and sustainable development. There are numerous challenges associated with sustainability and digitization, the need to consider new business models capable of extracting value, data ownership and sharing and integration, as well as collaboration across the entire supply chain of a product. In order to generate value, effectively developing a complex system based on sustainability principles is a challenge that requires a deep commitment to both technological factors, such as data and platforms, and human dimensions, such as trust and collaboration. Regular study, research and implementation must be part of the road to sustainable solutions. Consequently, this topic will analyze growth models and techniques aimed at achieving intergenerational equity in terms of economic, social and environmental well-being. 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