Summary of the studies that evaluated the role of antireflux therapy and surgery in the management of IPF.
\\n\\n
More than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\\n\\nOur breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\\n\\n“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\\n\\nAdditionally, each book published by IntechOpen contains original content and research findings.
\\n\\nWe are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
\\n\\n\\n\\n
\\n"}]',published:!0,mainMedia:{caption:"IntechOpen Maintains",originalUrl:"/media/original/113"}},components:[{type:"htmlEditorComponent",content:'
Simba Information has released its Open Access Book Publishing 2020 - 2024 report and has again identified IntechOpen as the world’s largest Open Access book publisher by title count.
\n\nSimba Information is a leading provider for market intelligence and forecasts in the media and publishing industry. The report, published every year, provides an overview and financial outlook for the global professional e-book publishing market.
\n\nIntechOpen, De Gruyter, and Frontiers are the largest OA book publishers by title count, with IntechOpen coming in at first place with 5,101 OA books published, a good 1,782 titles ahead of the nearest competitor.
\n\nSince the first Open Access Book Publishing report published in 2016, IntechOpen has held the top stop each year.
\n\n\n\nMore than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\n\nOur breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\n\n“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\n\nAdditionally, each book published by IntechOpen contains original content and research findings.
\n\nWe are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
\n\n\n\n
\n'}],latestNews:[{slug:"intechopen-supports-asapbio-s-new-initiative-publish-your-reviews-20220729",title:"IntechOpen Supports ASAPbio’s New Initiative Publish Your Reviews"},{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"}]},book:{item:{type:"book",id:"6287",leadTitle:null,fullTitle:"Cyclodextrin - A Versatile Ingredient",title:"Cyclodextrin",subtitle:"A Versatile Ingredient",reviewType:"peer-reviewed",abstract:"The book is devoted to the highly versatile and potential ingredient Cyclodextrin, a family of cyclic oligosaccharides composed of ?-(1,4)-linked glucopyranose subunits. Its molecular complexation phenomena and negligible cytotoxic effects attribute toward its application such as in pharmaceuticals, cosmetics, food, agriculture, textile, separation process, analytical methods, catalysis, environment protection, and diagnostics. Efforts have also been made to concentrate on recent research outcomes along with future prospects of cyclodextrins to attract the interest of scientists from the industry and academia. The contributions of the authors are greatly acknowledged, without which this compilation would not have been possible.",isbn:"978-1-78923-069-7",printIsbn:"978-1-78923-068-0",pdfIsbn:"978-1-83881-379-6",doi:"10.5772/intechopen.69187",price:139,priceEur:155,priceUsd:179,slug:"cyclodextrin-a-versatile-ingredient",numberOfPages:332,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"27dcbf4c42d7e03a836fbce72ac5af7a",bookSignature:"Poonam Arora and Neelima Dhingra",publishedDate:"April 18th 2018",coverURL:"https://cdn.intechopen.com/books/images_new/6287.jpg",numberOfDownloads:16902,numberOfWosCitations:28,numberOfCrossrefCitations:24,numberOfCrossrefCitationsByBook:2,numberOfDimensionsCitations:66,numberOfDimensionsCitationsByBook:3,hasAltmetrics:1,numberOfTotalCitations:118,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"May 30th 2017",dateEndSecondStepPublish:"June 20th 2017",dateEndThirdStepPublish:"September 16th 2017",dateEndFourthStepPublish:"December 15th 2017",dateEndFifthStepPublish:"February 13th 2018",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6,7",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"133977",title:"Mrs.",name:"Poonam",middleName:null,surname:"Arora",slug:"poonam-arora",fullName:"Poonam Arora",profilePictureURL:"https://mts.intechopen.com/storage/users/133977/images/5431_n.jpg",biography:"Dr. Poonam obtained her B. Pharmacy and M. Pharmacy (Pharmaceutical Chemistry) degrees from Panjab University, Chandigarh, India and Ph.D. (Pharmaceutical Chemistry) in 2011 from the same institute. She is currently working as Assistant Professor at GHG Khalsa College of Pharmacy, Gurusar Sadhar, Ludhiana, Punjab. She has an experience of more than 10 years in teaching and research. Her major areas of research are cyclodextrin complexation studies of pharmaceutical drugs, polymorph/solvatomorph studies and design and synthesis of cocrystals and eutectic mixtures. Her research work has been credited with 2 national patents, 30 research and review articles in peer-reviewed national and international journals. Besides this, she has one book and two book chapters to her credit. She was awarded best poster award in 62nd Indian Pharmaceutical Congress held in Manipal, India in December 2010. She has guided eight M. Pharmacy research students and two research scholars are enrolled under her for Ph.D. studies.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"1",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:{id:"208896",title:"Dr.",name:"Neelima",middleName:null,surname:"Dhingra",slug:"neelima-dhingra",fullName:"Neelima Dhingra",profilePictureURL:"https://mts.intechopen.com/storage/users/208896/images/5433_n.jpg",biography:"Dr. Neelima Dhingra obtained her B. Pharmacy, M. Pharmacy (Pharmaceutical Chemistry), and Ph.D. (Pharmaceutical Chemistry) from the University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh. Presently, serving as an Assistant Professor at the Department of Pharmaceutical Chemistry, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh. She has more than 10 years of teaching and research experience. Her major area of research focuses on designing (2D-QSAR, 3D-QSAR), synthesis, spectroscopy analysis, physicochemical parameters and biological evaluation (in vitro, in vivo, in silico) of steroidal derivatives especially 5- alpha reductase inhibitors. Her research work has been credited with 2 US patents, 4 national patents, 26 research papers in the peer reviewed national and international journals, 8 national awards including INDIRA VASUDEVAN AWARD (Best Paper Award in the field of cancer research) and one international BEST RESEARCH PAPER AWARD at the second international conference on Pharmacology and Pharmaceutical Sciences in Singapore in 2014. Presently she is handling government agency (UGC, CSIR, DST) funded projects worth Rs 40 lakhs especially in the field of prostate, breast and lung cancer.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"0",institution:null},coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"494",title:"Bioorganic Chemistry",slug:"organic-chemistry-bioorganic-chemistry"}],chapters:[{id:"58579",title:"Cyclodextrins: Past and Present",doi:"10.5772/intechopen.72736",slug:"cyclodextrins-past-and-present",totalDownloads:1979,totalCrossrefCites:6,totalDimensionsCites:11,hasAltmetrics:0,abstract:"Cyclodextrins (CDs) are cyclic oligosaccharides produced by enzymatic degradation of starch. The most common CDs are the main natural ones, α, β and γ, which are constituted of 6, 7 and 8 glucopyranose units, respectively. The CD structure forms a torus or doughnut ring and the molecule actually exists as a truncated cone. The outer side of the toroid is hydrophilic in nature due to the hydroxyl groups of the glucopyranose units while the internal cavity is relatively apolar. Thus, CDs have a high potential to entrap entirely or partially a wide variety of compounds in a process known as complexation. This gives them new physico-chemical properties and characteristics. The main applications of CDs in drug formulation rely on CD complexation and include the protection of easily oxidizable molecules or the improvement of aqueous solubility. The use of CDs in analytical chemistry is based on his host-guest recognition property, known as supramolecular complex formation. Currently, CDs are successfully used in molecular recognition-based methods like chromatographic separations, spectroscopic and electroanalyses. Quiral analytical separations are a CD area of special relevance. In this work, attention is paid to more recent references, especially to selected reviews.",signatures:"Julia Martin, Enrique Jacobo Díaz-Montaña and Agustín G. Asuero",downloadPdfUrl:"/chapter/pdf-download/58579",previewPdfUrl:"/chapter/pdf-preview/58579",authors:[{id:"190870",title:"Dr.",name:"Agustín G.",surname:"Asuero",slug:"agustin-g.-asuero",fullName:"Agustín G. Asuero"},{id:"190871",title:"Dr.",name:"Julia",surname:"Martín",slug:"julia-martin",fullName:"Julia Martín"},{id:"221421",title:"Mr.",name:"Enrique",surname:"Diaz-Montaña",slug:"enrique-diaz-montana",fullName:"Enrique Diaz-Montaña"}],corrections:null},{id:"59110",title:"Aggregation of Cyclodextrins: Fundamental Issues and Applications",doi:"10.5772/intechopen.73532",slug:"aggregation-of-cyclodextrins-fundamental-issues-and-applications",totalDownloads:1189,totalCrossrefCites:3,totalDimensionsCites:12,hasAltmetrics:0,abstract:"The aggregation of cyclodextrins (CD) in aqueous solution is an old, yet still vastly unexplored topic that has been studied at least since the 1980s. At that time, few authors took into consideration the possibility of formation of aggregates for the interpretation of thermodynamic and thermophysical properties of CDs in aqueous solution. The aggregates appear at quite low CD concentrations and seem to encompass only a small number of CD molecules. They also occur in water in the presence of hydrophobic or amphiphilic moieties, including surfactants, assuming a preassembled state with the hydrophobic chains threading through one or two CDs. After a long period in which it has been neglected, CD aggregation is now a hot topic and one far from gathering consensus. In this chapter, a timely and critical review on the phenomenon of CD aggregation and the respective supramolecular properties, including some computational rationales, will be presented. A comprehensive summary of CD aggregates studied to date, indicating the formation conditions, characterization techniques, and applications, is also provided.",signatures:"Tânia F.G.G. Cova, Sandra M.A. Cruz, Artur J.M. Valente, Paulo E.\nAbreu, Jorge M.C. Marques and Alberto A.C.C. Pais",downloadPdfUrl:"/chapter/pdf-download/59110",previewPdfUrl:"/chapter/pdf-preview/59110",authors:[{id:"40736",title:"Dr.",name:"Sandra",surname:"Cruz",slug:"sandra-cruz",fullName:"Sandra Cruz"},{id:"212006",title:"Prof.",name:"Artur",surname:"Valente",slug:"artur-valente",fullName:"Artur Valente"},{id:"212012",title:"Dr.",name:"Tânia",surname:"Cova",slug:"tania-cova",fullName:"Tânia Cova"},{id:"212013",title:"Prof.",name:"Paulo",surname:"Abreu",slug:"paulo-abreu",fullName:"Paulo Abreu"},{id:"212014",title:"Prof.",name:"Jorge",surname:"Marques",slug:"jorge-marques",fullName:"Jorge Marques"},{id:"212015",title:"Prof.",name:"Alberto",surname:"Pais",slug:"alberto-pais",fullName:"Alberto Pais"}],corrections:null},{id:"59189",title:"Interactions between Bio-Based Compounds and Cyclodextrins",doi:"10.5772/intechopen.73531",slug:"interactions-between-bio-based-compounds-and-cyclodextrins",totalDownloads:1114,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Bio-based compounds, such as “green” surfactants and phytochemicals, are regarded as future sustainable resources for a vast range of applications in a modern society increasingly demanding economical, social, and environmental awareness. Natural compounds from plants (phytochemicals) are very sought by the pharmaceutical, cosmetic, and food industries. On the other hand, the growing interest in “green” surfactants (e.g., carbohydrate-based) is due to, inter alia, their preparation from renewable raw materials, ready biodegradability, and biocompatibility, among other reasons of fundamental, practical, economical, and environmental orders. Despite the wide range of potential applications of these bio-based compounds, their practical use is still limited due to many reasons such as poor aqueous solubility, volatility, reactivity, etc. Generally, when complexed with cyclodextrins, these bio-based compounds enhance considerably their performance and potential applications. Thus, this chapter aims at recalling some general fundamental aspects of phytochemicals and “green” surfactants, such as structure, function, and applications. In addition, their interactions with cyclodextrins are discussed from a physicochemical point of view with special focus on the techniques, mathematic modeling, and thermodynamic parameters (e.g., interactions, stoichiometries, association constants, etc.).",signatures:"Bruno Filipe Figueiras Medronho, Sandra Gonçalves, Raquel\nRodríguez-Solana, Artur J.M. Valente and Anabela Romano",downloadPdfUrl:"/chapter/pdf-download/59189",previewPdfUrl:"/chapter/pdf-preview/59189",authors:[{id:"212006",title:"Prof.",name:"Artur",surname:"Valente",slug:"artur-valente",fullName:"Artur Valente"},{id:"175614",title:"Dr.",name:"Bruno",surname:"Medronho",slug:"bruno-medronho",fullName:"Bruno Medronho"},{id:"193464",title:"Prof.",name:"Anabela",surname:"Romano",slug:"anabela-romano",fullName:"Anabela Romano"},{id:"193968",title:"Dr.",name:"Sandra",surname:"Gonçalves",slug:"sandra-goncalves",fullName:"Sandra Gonçalves"},{id:"232009",title:"Dr.",name:"Raquel",surname:"Rodríguez-Solana",slug:"raquel-rodriguez-solana",fullName:"Raquel Rodríguez-Solana"}],corrections:null},{id:"57792",title:"Use of 2-Hydroxypropyl-Beta-Cyclodextrin for Niemann-Pick Type C Disease",doi:"10.5772/intechopen.71970",slug:"use-of-2-hydroxypropyl-beta-cyclodextrin-for-niemann-pick-type-c-disease",totalDownloads:1168,totalCrossrefCites:0,totalDimensionsCites:4,hasAltmetrics:1,abstract:"Niemann-Pick disease type C (NPD-C) is a rare neurodegenerative disorder characterized by a lysosomal storage disorder. Treatment has been supportive and symptomatic. In animal studies, 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) showed a significant decrease in cerebellar damage, neurological progression, and higher lifespan. Based on these results, HP-β-CD has been tested in NPD-C patients for last 8 years. The first compassionate uses of intravenous HP-β-CD obtained a limited improvement in neurological symptoms, probably associated to the non-permeation of the blood-brain barrier. The change or combination with intrathecal administrations of HP-β-CD achieved higher benefits, especially improvement or stabilization of NPD-C progression. Biomarkers of neurological cholesterol homeostasis are being investigated in order to quantify the response of HP-β-CD treatment. The results of a clinical trial recently published have reproduced the slowing of NPD-C progression in 14 patients treated with a dose-escalation protocol of HP-β-CD intrathecal monthly infusions, with respect to a historical comparison cohort. The safety profile of this therapy is acceptable, being the loss of hearing as the most frequent adverse event. However, some severe toxicities have been reported in relation with HP-β-CD, including chemical meningitis and fever. The short experience with HP-β-CD suggested that it could be effective in the management of NPD-C.",signatures:"Juan Eduardo Megías-Vericat, María José Company-Albir, Ana\nAlejandra García-Robles and José Luis Poveda",downloadPdfUrl:"/chapter/pdf-download/57792",previewPdfUrl:"/chapter/pdf-preview/57792",authors:[{id:"185102",title:"Dr.",name:"Juan Eduardo",surname:"Megías-Vericat",slug:"juan-eduardo-megias-vericat",fullName:"Juan Eduardo Megías-Vericat"},{id:"185108",title:"Dr.",name:"Jose Luis",surname:"Poveda",slug:"jose-luis-poveda",fullName:"Jose Luis Poveda"},{id:"213456",title:"Dr.",name:"María José",surname:"Company-Albir",slug:"maria-jose-company-albir",fullName:"María José Company-Albir"},{id:"213457",title:"Dr.",name:"Ana Alejandra",surname:"García-Robles",slug:"ana-alejandra-garcia-robles",fullName:"Ana Alejandra García-Robles"}],corrections:null},{id:"59347",title:"Room at the Top as well as at the Bottom: Structure of Functional Food Inclusion Compounds",doi:"10.5772/intechopen.74162",slug:"room-at-the-top-as-well-as-at-the-bottom-structure-of-functional-food-inclusion-compounds",totalDownloads:1135,totalCrossrefCites:3,totalDimensionsCites:4,hasAltmetrics:0,abstract:"Cyclodextrins (CDs) have been hanging around research laboratories, since their discovery by Villiers. When Schardinger identified the three naturally occurring forms—α, alpha; β, beta; and γ, gamma—they were called “Schardinger sugars.” Then it was found that CDs have the ability to bind with many different types of molecules in their cavities. Cyclodextrins are oligosaccharides obtained by enzymatic means from starch-containing raw materials such as corn. The characteristic feature of cyclodextrins is their ring-shaped, three-dimensional structure, with a hydrophobic cavity in the center, which is capable of receiving a lipophilic “guest” molecule. The hydrophilic outer surface ensures compatibility with aqueous systems. The specific properties of CDs opened up a wide range of application in food fields. Molecular encapsulation of food ingredients through cyclodextrins is intended to improve the stability of the ingredients, by extending the shelf life of the products. The results of accelerated and long-term stability tests have demonstrated that the stability of food ingredients encapsulated by cyclodextrins has outpaced those of traditionally formulated ones. The technological advantages of using cyclodextrins in food systems and food processing technologies are also manifested in the improvement of sensory and nutritional properties. Examples of food products are presented to demonstrate the importance of cyclodextrin-based molecular inclusion technology in the food industry.",signatures:"Aida Moreira da Silva",downloadPdfUrl:"/chapter/pdf-download/59347",previewPdfUrl:"/chapter/pdf-preview/59347",authors:[{id:"214972",title:"Associate Prof.",name:"Aida",surname:"Moreira Da Silva",slug:"aida-moreira-da-silva",fullName:"Aida Moreira Da Silva"}],corrections:null},{id:"60182",title:"Cyclodextrin-Based Nanofibers and Membranes: Fabrication, Properties and Applications",doi:"10.5772/intechopen.74737",slug:"cyclodextrin-based-nanofibers-and-membranes-fabrication-properties-and-applications",totalDownloads:1162,totalCrossrefCites:2,totalDimensionsCites:5,hasAltmetrics:1,abstract:"Cyclodextrin (CD)-based electrospun nanofibers have become critical role players in the water treatment arena due to their high porosities, small diameters, high surface area-to-volume ratio and other unique properties they exhibit. Investigations demonstrate that nanofibers containing CD molecules can be facially blended with other polymeric species and/or photocatalytic and magnetic nanoparticles to enhance their rates of adsorption, inclusion complexation and selective photodegradation. These properties make them excellent candidates for the removal of water pollutants. On the other hand, the electrospinning process has become the method of choice in the fabrication of various types of CD nanofibrous mats due to its versatility, cost-effectiveness and its potential for the mass production of uniform nanofibers. CDs and CD-derivatives have also found application in membrane technologies, particularly in mixed matrix and thin film composite membranes. CD-blended membranes display improved performances in terms of selectivity, rejection, permeation and flux with reduced fouling propensities and can be used for drinking water purification and removal of emerging micropollutants. This chapter critically reviews CD-based electrospun nanofibers looking at their production, characterization methods and various applications. The use of CDs as membrane materials and how they can be fully explored in water treatment are also investigated.",signatures:"Mandla B. Chabalala, Bonisiwe C. Seshabela, Stijn W.H. Van Hulle,\nBhekie B. Mamba, Sabelo D. Mhlanga and Edward N. Nxumalo",downloadPdfUrl:"/chapter/pdf-download/60182",previewPdfUrl:"/chapter/pdf-preview/60182",authors:[{id:"178092",title:"Dr.",name:"Bhekie",surname:"Mamba",slug:"bhekie-mamba",fullName:"Bhekie Mamba"},{id:"185134",title:"Prof.",name:"Sabelo",surname:"Mhlanga",slug:"sabelo-mhlanga",fullName:"Sabelo Mhlanga"},{id:"211976",title:"M.Sc.",name:"Mandla",surname:"Chabalala",slug:"mandla-chabalala",fullName:"Mandla Chabalala"},{id:"212001",title:"Ms.",name:"Charlotte Bonisiwe",surname:"Seshabela",slug:"charlotte-bonisiwe-seshabela",fullName:"Charlotte Bonisiwe Seshabela"},{id:"212003",title:"Prof.",name:"Edward",surname:"Nxumalo",slug:"edward-nxumalo",fullName:"Edward Nxumalo"}],corrections:null},{id:"59844",title:"β-Cyclodextrins as Encapsulating Agents of Essential Oils",doi:"10.5772/intechopen.73568",slug:"-cyclodextrins-as-encapsulating-agents-of-essential-oils",totalDownloads:1809,totalCrossrefCites:7,totalDimensionsCites:13,hasAltmetrics:0,abstract:"Many scientific studies have made advances in the ability to encapsulate natural extracts by cyclodextrins. These studies have addressed the physical and chemical conditions of the encapsulation reactions, employed several types of essential oils and characterized the microcapsules as to their ability to release encapsulated active principles. The essential oils studies with cyclodextrin encapsulation processes have been highly varied. However, the most studied are the essential oils with antimicrobial and antioxidant capacities. The essential antimicrobial and antioxidant oils are easily degraded. In the presence of oxygen, they are oxidized, and at low temperatures, they are volatilized and decomposed. Thus, cyclodextrins are coatings capable of protecting these essential oils from environmental conditions and agents capable of promoting oil degradation, in addition to controlling their release. In this chapter of the book, we review scientific papers that examine the encapsulation of antimicrobial essential oils and antioxidant essential oils with β-cyclodextrins.",signatures:"Ana Paula Capelezzo, Laura Cassol Mohr, Francieli Dalcanton,\nJosiane Maria Muneron de Mello and Márcio Antônio Fiori",downloadPdfUrl:"/chapter/pdf-download/59844",previewPdfUrl:"/chapter/pdf-preview/59844",authors:[{id:"213360",title:"Dr.",name:"Márcio",surname:"Antônio Fiori",slug:"marcio-antonio-fiori",fullName:"Márcio Antônio Fiori"},{id:"215608",title:"Dr.",name:"Francieli",surname:"Dalcanton",slug:"francieli-dalcanton",fullName:"Francieli Dalcanton"},{id:"222177",title:"MSc.",name:"Laura Cassol",surname:"Mohr",slug:"laura-cassol-mohr",fullName:"Laura Cassol Mohr"},{id:"222178",title:"MSc.",name:"Ana Paula",surname:"Capelezzo",slug:"ana-paula-capelezzo",fullName:"Ana Paula Capelezzo"},{id:"222181",title:"Dr.",name:"Josiane Maria Muneron De",surname:"Mello",slug:"josiane-maria-muneron-de-mello",fullName:"Josiane Maria Muneron De Mello"}],corrections:null},{id:"60242",title:"Advanced Polymer-Surfactant Systems via Self-Assembling",doi:"10.5772/intechopen.74618",slug:"advanced-polymer-surfactant-systems-via-self-assembling",totalDownloads:1124,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"This chapter summarizes the formulation of supramolecular polymers built via noncovalent and β-cyclodextrin (β-CD) host-guest interactions. The self-assembling polymeric (SAP-AP) systems were formulated by mixing associative polymers with an anionic surfactant and β-CD. These SAP-AP systems were characterized by rheological analysis and several techniques to establish their stability under mechanical shear, high ionic strength, and high temperature. The experimental results demonstrate that the SAP-AP systems display enhanced viscoelastic properties, shear stability, superior structural strength, and tolerance to high-salinity brines relative to the corresponding baseline polymers.",signatures:"Laura Romero-Zerón and Xingzhi Jiang",downloadPdfUrl:"/chapter/pdf-download/60242",previewPdfUrl:"/chapter/pdf-preview/60242",authors:[{id:"109465",title:"Dr.",name:"Laura",surname:"Romero-Zerón",slug:"laura-romero-zeron",fullName:"Laura Romero-Zerón"},{id:"238120",title:"Mr.",name:"Xingzhi",surname:"Jiang",slug:"xingzhi-jiang",fullName:"Xingzhi Jiang"}],corrections:null},{id:"59730",title:"Supramolecular Polymer-Surfactant System for Heavy Oil Recovery",doi:"10.5772/intechopen.75368",slug:"supramolecular-polymer-surfactant-system-for-heavy-oil-recovery",totalDownloads:1209,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Water soluble polymers are widely used as mobility control agents for enhanced oil recovery (EOR). Yet, in harsh reservoir environments (i.e., elevated temperatures and high ionic strength), the applicability of conventional polymers is limited. This issue has been somewhat resolved through the chemical synthesis of polymers having functional moieties such as sulfonic acid groups and/or n-vinylpyrrolidone. Another approach to circumvent expensive chemical syntheses, it is the formulation of supramolecular polymers built via non-covalent and β-cyclodextrin (β-CD) host-guest interactions. In this study, an advanced polymer-surfactant (SAP-AP1) system formulated via the self-assembling of an associative polymer with an anionic surfactant and β-CD was evaluated as a mobility control agent to displace and recover heavy oil (i.e., 2560 cP at 25°C). Displacement tests employing unconsolidated sand-pack systems were carried out at simulated heavy oil reservoir conditions. The experimental results demonstrate that the SAP-AP1 produces a stable viscous displacement front that results in more efficient volumetric sweep, faster reduction of the water/oil ratio (WOR), and incremental oil recovery (e.g., 19% higher incremental oil recovery relative to the baseline polymer). The SAP-AP1 system shows potential for EOR applications at economically favorable conditions.",signatures:"Laura Romero-Zerón and Xingzhi Jiang",downloadPdfUrl:"/chapter/pdf-download/59730",previewPdfUrl:"/chapter/pdf-preview/59730",authors:[{id:"109465",title:"Dr.",name:"Laura",surname:"Romero-Zerón",slug:"laura-romero-zeron",fullName:"Laura Romero-Zerón"}],corrections:null},{id:"59567",title:"Promising Use of Cyclodextrin-Based Non-Viral Vectors for Gene and Oligonucleotide Drugs",doi:"10.5772/intechopen.74614",slug:"promising-use-of-cyclodextrin-based-non-viral-vectors-for-gene-and-oligonucleotide-drugs",totalDownloads:1148,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:0,abstract:"Genes, short-hairpin RNA (shRNA), small-interfering RNA (siRNA), and decoy DNA can be principally used as tools for the treatment and prevention of many disorders, including but not limited to cancers, genetic disorders, and inherited diseases. This is accomplished by introducing exogenous nucleic acids into mammalian cells to modulate gene expression. However, direct use of such oligonucleotide drugs is hampered by several barriers, including their degradation by nucleases present in the blood and extracellular fluid, cell-membrane impermeability, and their retention in endosomes. To address this issue, the development of safe and effective delivery vectors has emerged as the main fundamental challenge for successful gene and oligonucleotide therapy. Due to the intrinsic risks associated with viral vectors, non-viral vectors have attracted increasing attention as gene and oligonucleotide carriers. We originally developed various cyclodextrin (CyD) conjugates with polyamidoamine (PAMAM) dendrimers as novel CyD-based polymers for the delivery of plasmid DNA, siRNA, shRNA, and decoy DNA. In this review, we describe the recent findings on PAMAM dendrimer conjugates using CyDs as carriers for gene, shRNA, siRNA, and decoy DNA delivery.",signatures:"Ahmed F.A. Mohammed, Keiichi Motoyama, Taishi Higashi and\nHidetoshi Arima",downloadPdfUrl:"/chapter/pdf-download/59567",previewPdfUrl:"/chapter/pdf-preview/59567",authors:[{id:"211513",title:"Dr.",name:"Hidetoshi",surname:"Arima",slug:"hidetoshi-arima",fullName:"Hidetoshi Arima"}],corrections:null},{id:"59099",title:"Encapsulation of Essential Oils by Cyclodextrins: Characterization and Evaluation",doi:"10.5772/intechopen.73589",slug:"encapsulation-of-essential-oils-by-cyclodextrins-characterization-and-evaluation",totalDownloads:1584,totalCrossrefCites:1,totalDimensionsCites:8,hasAltmetrics:1,abstract:"The essential oils normally had low physicochemical stability and low solubility in water. These facts limit their industrial applications in general and in food formulations particularly. This chapter characterizes the physicochemical properties and the antioxidant and antimicrobial activities of three encapsulated essential oils – guava leaf, yarrow and black pepper essential oils – in hydroxypropyl-β-cyclodextrin (HPβCD).",signatures:"Jaruporn Rakmai, Benjamas Cheirsilp, Antonio Cid, Ana Torrado-\nAgrasar, Juan Carlos Mejuto and Jesus Simal-Gandara",downloadPdfUrl:"/chapter/pdf-download/59099",previewPdfUrl:"/chapter/pdf-preview/59099",authors:[{id:"107288",title:"Dr.",name:"Antonio",surname:"Cid",slug:"antonio-cid",fullName:"Antonio Cid"},{id:"161326",title:"Prof.",name:"Jesus",surname:"Simal-Gandara",slug:"jesus-simal-gandara",fullName:"Jesus Simal-Gandara"},{id:"192394",title:"Prof.",name:"Juan",surname:"Mejuto",slug:"juan-mejuto",fullName:"Juan Mejuto"},{id:"213327",title:"Dr.",name:"Jaruporn",surname:"Rakmai",slug:"jaruporn-rakmai",fullName:"Jaruporn Rakmai"},{id:"213328",title:"Prof.",name:"Benjamas",surname:"Cheirsilp",slug:"benjamas-cheirsilp",fullName:"Benjamas Cheirsilp"},{id:"213330",title:"Prof.",name:"Ana",surname:"Torrado-Agrasar",slug:"ana-torrado-agrasar",fullName:"Ana Torrado-Agrasar"}],corrections:null},{id:"59205",title:"β-Cyclodextrin as an Ionophore for Membrane Electrode",doi:"10.5772/intechopen.73597",slug:"-cyclodextrin-as-an-ionophore-for-membrane-electrode",totalDownloads:1128,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"This chapter included an explanation of the role of cyclodextrin as an ionophore for the preparation of voltammetric and potentiometric sensors for different compounds. There was a surveying of the different recorded cyclodextrin-based sensors for drug, organic, or inorganic cations. It also explained the performance characteristics for the first reported sensor for nickel based on β-cyclodextrin as an example.",signatures:"Mohsen M. Zareh",downloadPdfUrl:"/chapter/pdf-download/59205",previewPdfUrl:"/chapter/pdf-preview/59205",authors:[{id:"109097",title:"Prof.",name:"Mohsen",surname:"Zareh",slug:"mohsen-zareh",fullName:"Mohsen Zareh"}],corrections:null},{id:"58265",title:"Removal of an Azo Textile Dye from Wastewater by Cyclodextrin-Epichlorohydrin Polymers",doi:"10.5772/intechopen.72502",slug:"removal-of-an-azo-textile-dye-from-wastewater-by-cyclodextrin-epichlorohydrin-polymers",totalDownloads:1153,totalCrossrefCites:1,totalDimensionsCites:7,hasAltmetrics:0,abstract:"Native cyclodextrins (CDs), α-, β- and γ-CDs, were employed to synthetise three different cyclodextrin-based polymers using epichlorohydrin (EPI) as a cross-linker. These polymers were applied as adsorbent material to remove an azo textile dye, Direct Blue 78 (DB78), from water. The formation of inclusion complexes between the alone CDs and DB78 molecules were first studied in aqueous solutions. Then, adsorption experiments of the dye were performed by means of cyclodextrin/epichlorohydrin (CD/EPI) polymers. The effects of various parameters, such as contact time, adsorbent dosage, initial dye concentration, pH and temperature, were examined to determine the better adsorption conditions. The equilibrium isotherms and the adsorption kinetics were also analysed using opportune mathematic models. The chemical-physical characteristics and the morphology of the adsorbent polymers were, respectively, observed by differential scanning calorimetry and field emission scanning electron microscope. The CD/EPI polymers showed a very good ability in the removal of DB78 from aqueous solution; indeed, the maximum efficiencies in the dye removal were found to be about 99% for β-CD/EPI polymer and about 97% for γ-CD/EPI polymer, at pH 6 and 25°C conditions. It is possible to assume that the good adsorbent aptitude of CD/EPI polymers is due to their double peculiarity to include the dye in the inner cavity of CDs and to adsorb the dye on their porous surfaces by physical interaction.",signatures:"Paola Semeraro, José Antonio Gabaldón, Paola Fini, Estrella Núňez,\nJosé Antonio Pellicer, Vito Rizzi and Pinalysa Cosma",downloadPdfUrl:"/chapter/pdf-download/58265",previewPdfUrl:"/chapter/pdf-preview/58265",authors:[{id:"211706",title:"Prof.",name:"Pinalysa",surname:"Cosma",slug:"pinalysa-cosma",fullName:"Pinalysa Cosma"},{id:"222100",title:"Dr.",name:"Paola",surname:"Semeraro",slug:"paola-semeraro",fullName:"Paola Semeraro"},{id:"222102",title:"Prof.",name:"Josè Antonio",surname:"Gabaldon",slug:"jose-antonio-gabaldon",fullName:"Josè Antonio Gabaldon"},{id:"222103",title:"Dr.",name:"José Antonio",surname:"Pellicer",slug:"jose-antonio-pellicer",fullName:"José Antonio Pellicer"},{id:"222104",title:"Dr.",name:"Paola",surname:"Fini",slug:"paola-fini",fullName:"Paola Fini"},{id:"222105",title:"Dr.",name:"Vito",surname:"Rizzi",slug:"vito-rizzi",fullName:"Vito Rizzi"},{id:"222106",title:"Prof.",name:"Estrella",surname:"Nunez",slug:"estrella-nunez",fullName:"Estrella Nunez"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"2326",title:"Cellulose",subtitle:"Fundamental Aspects",isOpenForSubmission:!1,hash:"de85a5810169999b1c069d863593e56a",slug:"cellulose-fundamental-aspects",bookSignature:"Theo van de Ven and Louis Godbout",coverURL:"https://cdn.intechopen.com/books/images_new/2326.jpg",editedByType:"Edited by",editors:[{id:"130492",title:"Dr.",name:"Theo G.M.",surname:"Van De Ven",slug:"theo-g.m.-van-de-ven",fullName:"Theo G.M. 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The Universe outside their quantum model is a fragmented cosmos, where the matter is separated in different gradients of interaction of particles of fundamental level, which goes conforming scales of the matter until to shape the complex structures of all sidereal objects and the life that we know. However, in this process and for the alone presence of matter in the space is created a permanent will with persistent action and the long scope which is the gravitational field.
\nThe permanence of this field is the control aspects of regulation in the sidereal objects such as the movements, shape of the objects, shape of the local space, auto-gravitation, and conformation of the chemical structures. Also their self-recomposing, as well as the different natural process to the life as the kinematic equilibrium of the living beings, biorhythm, biochemical auto-regulations, etcetera, which requires sedimentation and other process that brings the gravitational field, as example, the connection in equilibrium levels depending of the position between all bodies in the space. In addition, the time is a consequence possible of the gravitational field which has an effect, the curvature, where the time being the distance between cause and effect; the instantons [1] 1 of the curvature energy is the distance between gravitational field and curvature in layers of the matter-energy that goes composing the sidereal objects and the Universe. Likewise, this determines an integrated action with the intention of connect the space-time with gravity as the encoding of the Universe, at least in the Einstein-Cartan field conception considering also the Dirac equation to the energy level.
\nLikewise, we have:
\n\n
Why the gravity intention is the cohesion? Because, in the beginning of the Universe, the only ingredient was energy. After the Big Bang, the energy was being fragmented in matter and other energy manifestations in the Universe, such as we know in our days. The gravity is the ingredient of that primal energy (the energy before the Big Bang), but this is the version of that primal energy when matter in the space and time appeared (as well as local time or global time in the Universe).
\nWhy the gravity intention is the shape? Because the Universe needs the gravity, to be used in the interpretations of elements of the Universe as are time, space, and energy. For example, space could be curvature, time could be second curvature (or torsion), and energy could be curvature energy in any of their modalities (first and second curvature energies).
\nThe Universe before their fragmentation (as has been interpreted in different cosmological theories in the beginning of the Universe) was conformed for energy due to the Big Bang. After when this was freeze gradually is conformed for a quantum process in an Early Universe composed in their totality by neutrinos as basic particles components. These neutrinos were differentiated for a natural process in new neutrinos giving some aspects of our Universe, as possibly the dark matter production. Other neutrino classes as the right-handed neutrinos were establishing with the baryon-genesis process; and other particles as the tachyons and the fermions/anti-fermions in a polarization process creating the charge
To establish the concept of agglutination and join of matter, first it is necessary to analyze the matter on their equivalence, the energy. Before, the Universe was only energy that was available, including the space and time. There was no space and time as we know. These were born after the Big Bang, when the quantum proliferation of particles begun, which conformed the matter particles, these atoms and after molecules. But, what determines this way to create matter. This requires an implicit conscience to create matter from microscopic level, and as this primal matter was part of an energy flow that defines space-time, the rest was stayed as matter energy but without the qualities of compactification of the mass. This gives the beginning to the gravitational energy, which is as natural as the manifestation of a field, the gravitational field.
\nBut, what happens with the space and time? How the gravity enters in the shape of the space and the time? Is gravity consequence of the intention of field in the Early Universe to control the inflation and of this way, to get a defined expansion with a causality-defined arrow?
\nThe torsion of the space is related with the electromagnetic phenomena of the space-time, and gravity more torsion can to define helicities, spins, and polarization rules between particles in the fundamental context of the matter, movement, and space.
\nSuch seems that the intentionality of the field in all the ages of the Universe has been maintaining the cohesion of the space-time such that the primordial component of field, which could be their connection will not be broken and the evolution obeys a sequence of microscopic model (Dirac model) of the Universe, where particles as neutrinos are re-combined. The Lagrangian model must involve the individual actions of gravity and torsion and their joint action,
\nthen the action involving the integral term of gravity and torsion is [3]:
\nwhere
The neutrinos and anti-neutrinos, as was mentioned before, are relevant and primordial in the production of matter to obtain gravity. The role of torsion is to explain the mechanisms of matter/anti-matter in gravity.
\nTo establish a Dirac model that gives explanation from the neutrinos and fermions (which establish the energy required to the coupling of torsion and gravity), the joint action between gravity and torsion comes through given torsion connections in the form:
\nHowever, there exist some ambiguities in the Einstein-Cartan theory with the Immirzi parameter. For example, actions can be modified by total derivatives, without effects to on-shell physics given to create movement (that is to say, equations of motion), but such terms confirm the structural coefficients to the quantum context. For other side, in pure gravity without torsion, one can add the following identically zero term due to Bianchi identities of symmetry properties of the Riemann tensor:
\nwhich confirm that the gravity establishes a global behavior in the Universe, not being true in the presence of torsion to the quantum level. For example, the action
\nwhere the tensor \n
But in the torsion case, the movement equations imply:
\nwhere is clear an inconsistent due to the equality between a vector
(a) Model of space-time with matter production without Immirzi parameter, but yes torsion. (b) Model of space-time with gravity and Immirzi parameter, including torsion. Observe the non-symmetric space created in the waving movement due to gravity.
The Holst term needs modification by the addition of fermions to become total derivative [3, 4], and provokes the coupling with the gravity to a global action on the space-time.
\nThe fermion-piece that will be added to the Holst action is:
\ntogether with Dirac kinetic term, the fermion action reads:
\nIf
which establish an equivalent to the Einstein-Cartan theory independent of Immirzi parameter
In Eq. (11),
which in simplified shape is written as
\nThen our model of cohesion by gravity is possible, since the scattering in the space-time is decreased under the last action (see \nFigure 1(a)\n).
\nLikewise, to energy level, let E be the energy, S be the space, and T be the time, and the corresponding topological spaces be \n
where in the context of the energy-(space-)time, an application
considering that f : T → E is a smooth mapping between manifolds (the composition
and analogy to the space S had a smooth mapping between manifolds S and E such as g : S → E, where the image \n
\n
Then a diffeomorphism between the space
that establishes the variation of the energy-(space-)time states in the covering space E [4]. Their differential is the curvature. Their integral is the variation principle
But how the energy states vary in this broth of space-(energy-)time given by the Universe \n
Let X, be a field acting in the space-time as energy that involves space and time [7]. An oriented string
\n
with the correspondence rule4\n
\nwhich is translated in the differential
\nWe observe that the diffeomorphism given in Eq. (22) is the field conscience operator (20) with topological definition in Eq. (6).
\nThe diffeomorphism
Then, the gravity conscience satisfies the identity by (20)–(22) as6:
\nwhere we have used the property of
where \n
The operator \n
\nExpression (24) proves the Conjecture 1.1, given in Section 1, since this demonstrates that the field is a matter-production source (the particle process does appear 2-spin particles expressed inside the energy integral) that is to say, the gravity is the performance of the space-time, and
\n
Likewise, the gravity intention ℑ
Finally, we can affirm considering the Dirac field equation and coordinates systems given for
Here is where appears the expression of difference of the energy-matter tensor to the equation of field (23), to the curvature tensor
In [13], it was concluded that the torsion field stays univocally determined through
Then this treatment to obtain a detailed description through microscopic context in field theory of the gravity (as matter-energy that is produced in the nucleon-synthesis, where is originated the matter and with it the fragmented Universe) is known with precision.
\nBut, these material products (such as planets, stars, galaxies, nebulas, etc.) are followed and joined by wave-links of gravity which conform their orbits and relative positions in the Universe.
\nWe could say that the dark matter is the result of energy-matter with hadrons in action.
\nAs was mentioned in the beginning of this chapter, the inflation is normed by the matter production and for the existence of inflatons (condensation of gravitinos, which come of the interactions in the leptogenesis (\nFigure 2\n)). This determines the first inflation in the double inflation determined in the conformal SUGRA model which corresponds to our string model
Evolution of the Universe and gravitational sequence of the energy-matter tensor [
Energy-matter tensor development in the lepto-genesis and baryon-genesis processes. The SB SUSY region or area is where takes form the space
Idiopathic Pulmonary Fibrosis (IPF) is the most common type of Idiopathic Interstitial Pneumonia. It is more prevalent in men, and its incidence increases with age, especially beyond the fifth decade [1]. Its incidence is estimated to be 3–9 cases per 100,000 per year in the western hemisphere [2]. As per a systematic review, the prevalence is estimated to be 0.5–27.9/100,000 [3]. Although newer therapies such as Pirfenidone and Nintedanib are available to slow the progression of the disease, the mortality and prognosis remain dismal, comparable to that of certain malignancies [4]. A key consideration has been the lack of optimal understanding of the pathophysiological mechanisms underlying the disease process, as interventions can then be targeted to modify the disease process and achieve better outcomes for the patients [4]. In a genetically susceptible individual, many risk factors have been proposed [1]. One such factor that has been closely associated with IPF is Gastroesophageal reflux disease (GERD) [1]. Their association has been hypothesized, studied, and targeted therapeutically. However, its role as a causative and aggravating factor has not yet been crystallized. Our chapter aims to review the association of GERD with IPF, its alleged role in causing or promoting lung injury, the effect of GERD therapy on IPF, recommendations from clinical guidelines, and the direction for future research.
GERD is a disease caused by reflux of stomach contents into the esophagus and beyond, causing troublesome symptoms and complications [5]. It causes esophageal and stomach symptoms characterized by chest pain, nausea, bloating, heartburn, and regurgitation. It can also cause extraesophageal symptoms such as throat pain, burning, lump in the throat, the sensation of needing to clear the throat, hoarseness of voice, cough, wheezing, bronchospasm, etc. [5, 6]. Importantly not all reflux events are symptomatic as there could be non-acid reflux [5, 6, 7].
Prevalence of GERD is very common in the western world, with North American estimates being 18.1–27.8% [8]. Europe, similarly, has a prevalence of up to 25% [8]. In a United Kingdom general practice database, IPF was much more likely to be associated with a diagnosis of GERD (65%) or use of anti-reflux therapy (71%) when compared to controls [4, 7, 9]. The prevalence of erosive esophagitis and hiatal hernia, both of which are associated with increased reflux, is also much higher in pulmonary fibrosis patients when compared to the general population [8, 10]. Hence there is a strong epidemiological association between these two disease entities.
GERD occurs commonly as a result of increased frequency of transient lower esophageal sphincter relaxations (TLESRs), which are defined as brief moments of lower esophageal sphincter tone inhibition that are independent of a swallow [11]. Other pathophysiological mechanisms implicated in the causation of GERD are reduced lower esophageal sphincter (LES) pressure, reduced upper esophageal sphincter pressure, reduced esophageal motility, Hiatal hernias, which distorts the gastroesophageal junctional anatomy, impairment of esophageal clearance, and sluggish gastric emptying [4, 5, 7]. A combination of these factors leads to the reflux establishing contact with mucosa in the upper gastrointestinal tract, pharynx, tracheobronchial tree, and lungs, causing extra esophageal symptoms as previously described [4, 5, 7].
Evaluation of GERD can be made by direct visual examination by esophagogastroduodenoscopy (EGD). The chief advantage is that the mucosa can be visualized directly and is helpful in the diagnosis of possible complications of GERD, including Barret’s esophagitis, esophagitis, gastritis, gastric and esophageal stricture, and malignancy. However, pH monitoring better evaluates reflux, wherein a pH measuring probe is placed in the esophagus [5]. The primary measurement is the amount of time spent with a pH less than 4.0 [5]. However, it has its inherent limitations, as non-acid reflux cannot be measured and can remain totally asymptomatic. This limitation has been overcome by the placement of channels that measure impedance. Liquid reflux has low impedance and high conductance, while gaseous reflux, such as belching, has high impedance with low conductance [12]. Combined 24-hr multichannel intraluminal impedance-pH monitoring (MII-pH) are available to determine the amount of refluxate, its proximal extent, and/or the presence of both acid and weakly acidic reflux [7, 13]. The chief metric when using MII-pH is the “Total number of refluxes” (Pathological when more than 80 and normal if less than 40 in a 24-hour period) and esophageal “Acid exposure time (AET)” as the percentage of time with pH less than 4.0 in the distal esophagus [14]. The use of MII-pH in GERD associated with extra esophageal disease, particularly in IPF, is rather novel and promising to help illuminate the pathophysiological mechanisms between the two diseases [15]. It is noteworthy that IPF belongs to a group of diseases that are only possibly or likely associated with GERD, and its role is only speculated [7]. The use and application of MII-pH for the study of extraesophageal diseases and symptoms has not been as productive as for typical GERD [7].
The relationship between IPF and GERD is quite intriguing. The epidemiological association suggests that there appear to be plausible biological and mechanical factors underlying this pathophysiology.
It is suggested that GERD is associated with decreased upper and lower esophageal sphincter tone (hypotensive esophagogastric junction) with or without increased frequency of transient lower esophageal sphincter relaxations (TLESRs), leading to increased refluxate with an associated micro-aspiration of the gastric contents into the trachea and lungs [16, 17, 18]. Contrary to this proposed theory, it has been proposed that lung fibrosis causes decreased lung compliance along with lower lung elasticity, resulting in increased negative intrathoracic pressure during inspiration that is transmitted to the mediastinal structures, including the esophagus and its sphincters [17]. This causes increased transient lower esophageal sphincter relaxations (TLESRs) with lower and upper esophageal sphincters [17]. There is also a pressure gradient across the diaphragm in respiratory diseases like IPF, which may promote these favorable refluxate mechanisms, especially during coughing, increased respiratory excursions during exacerbations, and may potentially be further aggravated by hypoxia/hypercapnia, medications like antacids, glucocorticoids, and obstructive sleep apnea/hypopnea syndromes [19]. Hiatal hernia alters the physical and physiologic function of the lower esophageal sphincter, thereby promoting reflux [20, 21, 22]. Furthermore, it has been proposed that esophageal dysmotility may contribute to reflux [23, 24]. Ultimately, the result of these phenomena is that the gastric refluxate, which contains both acidic and non-acidic contents, leads to delayed esophageal clearance and micro-aspiration in the tracheobronchial tree injure the pulmonary parenchyma consisting of both alveolar and interstitial components [4, 7, 19]. The healing of this injury eventually occurs by fibrosis, and the pulmonary remodeling that ensues culminates in a distorted fibrotic architecture [4, 7].
Many studies have been performed to provide evidence and study the relationship between GERD and IPF. Most of these studies have limitations and often conclude with contradictory results. Therefore, evidence has shown a co-existence and/or association between IPF and GERD. However, causality has yet to be determined [4, 7, 25].
Gao et al. conducted a study involving 69 IPF patients, 62 healthy volunteers, and 88 IPF negative GERD patients. The prevalence of GERD was high in patients with IPF, and in relation to their comparator group showed the variable presence of esophageal dysmotility and decreased lower and upper esophageal sphincter pressure. IPF patients also had increased reflux events proximally and impaired bolus transit time [16]. Raghu et al. studied 65 patients with IPF who were subjected to 24-h pH monitoring and esophageal manometry with a comparison group of 133 asthmatic patients and symptoms of GERD. The prevalence of abnormal gastroesophageal reflux in IPF patients was high at 87%, with 76% and 63% demonstrating abnormal distal and proximal esophageal acid exposures, respectively; a finding higher than within the comparison group [18]. The study also showed that the presence of GERD was not always symptomatic, and there was no correlation with IPF severity [18]. This was further confirmed in a study involving 28 patients with histologically confirmed IPF using hypopharyngeal multichannel intraluminal impedance (HMII) [26]. HMII used a specialized impedance catheter to directly measure laryngopharyngeal reflux (LPR) and full column reflux (reflux 2 cm distal to the upper esophageal sphincter). The study included 16 males and 12 females with a mean age of 60.4 years (range, 41–78) and a BMI of 28.4 (range, 21.1–38.1), respectively. Abnormal proximal exposure was present in 54% (15/28) of patients. This latter group was more likely to have a defective lower esophageal sphincter (LES) compared with those without (93% vs. 75%). Fourteen patients (56%) had abnormal esophageal motility, including aperistaltic esophagus (n = 9), suggesting that this may be common in this patient population [26].GERD was noted to be highly prevalent at more than 70% in patients with IPF; abnormal proximal reflux events such as LPR and full column reflux were also quite common despite a frequently negative DeMeester score (It is a composite of six different parameters which measures acid exposure giving a pH score used to diagnose GERD), suggesting that nonacid reflux (25% of patients) is prevalent in this patient population [26]. A high rate of esophageal mucosal injury and a longer acid clearance time was also noted [26].67–76% of the systematic review demonstrated abnormal esophageal acid exposure off PPI treatment [27].
In another study conducted by Savarino et al. [28], 40 IPF patients were studied alongside 40 non-IPF ILD patients and 50 healthy volunteers, who served as controls. Patients were off reflux therapy and underwent a High-resolution Lung CT scan (HRCT) and pH-impedance monitoring. Patients with IPF had significantly increased esophageal acid exposure, the number of acidic, weakly acidic, and proximal reflux events relative to the comparison groups. Pulmonary fibrosis HRCT scores correlated well with reflux episodes in both the distal and proximal esophagus. Patients with IPF had more bile acids and pepsin (p < 0.03) in bronchoalveolar lavage fluid (62% and 67%, respectively) and saliva (61% and 68%, respectively) relative to the comparison groups [28]. Gavini et al. conducted an elegant study involving 45 pre-transplants patients with IPF who had received pulmonary function tests within the last 3 months. Patients were off reflux therapy and had no reflux surgery. They measured GER on multichannel intraluminal impedance and pH study (MII-pH). Six pH/acid reflux parameters with corresponding MII/bolus reflux measures were prespecified. Multivariate analyses were applied using forward stepwise logistic regression. Severe pulmonary dysfunction was defined using diffusion capacity for carbon monoxide (DLCO) ≤40%. Abnormal total reflux episodes and prolonged bolus clearance time (OR = 1.21 p = 0.05), but not the refluxate pH values, were significantly associated with pulmonary dysfunction severity on univariate and multivariate analyses [29]. Overall, it appears that esophageal dysmotility, the total number of acidic, weakly acidic, and non-acidic refluxes with prolonged bolus clearance time, appear to impact the underlying lung pathology.
Animal and human studies have shown that the presence of gastric contents (pepsin, bile acids, gastric acid) via microaspiration in bronchoalveolar lavage (BAL) fluid can cause tissue damage and inflammatory infiltrate [28, 30, 31, 32, 33, 34, 35]. Histologically presence of thickened alveolar walls, collagen deposition in the interstitium, epithelial-mesenchymal transition, and presence of various fibrogenic factors has been found [28, 34, 35]. The latter consists of TGF-beta, NFκB, Farnesoid X receptor, and others. TGF-beta can be induced by gastric contents, leading to fibroblast proliferation and fibroproliferative changes [4, 7].
There has been a long-standing interest in the use of anti-secretory therapy/anti-reflux surgery in IPF patients, given that GERD has been thought of as having a relationship with IPF [4, 7]. While it is not unreasonable to give anti-secretory therapy to patients with symptomatic GERD patients, it has certainly been hard to objectively justify the use in all patients with IPF, some of whom may not have any reflux or reflux with non-acidic gastric contents [36]. This has indeed been a recommendation from international guidelines, albeit it was a week level of recommendation [37]. As per literature, PPIs are the most frequently used medications, and further discussion will relate henceforth to PPI.
PPIs are known for increasing the pH of gastric acid; a mechanism thought to prevent microaspiration of acidic contents into the lung and hence potentially protect against acid-induced pneumonitis [37]. In vitro studies show that PPIs like Esomeprazole have pleiotropic effects, can inhibit expression of pro-inflammatory molecules like vascular cell adhesion molecule-1, inducible nitric oxide synthase, tumor necrosis factor-alpha (TNF-α), and interleukins (IL-1β and IL-6), and exhibit antioxidant and anti-fibrotic properties by downregulation of profibrotic proteins including receptors for transforming growth factor β (TGFβ), fibronectin and matrix metalloproteinases (MMPs) [38, 39]. They may also inhibit apoptosis of pneumocytes expressing Surfactant (SP-C) [38, 39]. Retrospective studies have also demonstrated that PPIs may prolong transplant-free survival of IPF patients [38, 39].
However, PPIs are not without risks. They have been shown to alter the microbiome of the respiratory tract and increase the risk of pneumonia [17]. Furthermore, they increase the risk of micronutrient deficiencies like Vitamin B12, cause dementia,
Anti-reflux surgery is an important therapeutic option in patients with GERD. Nissen fundoplication and Laparoscopic anti-reflux surgery (LARS) are the two most performed surgeries, both of which are generally safe in IPF [4, 14]. Lee JS et al. reported a retrospective cohort of 204 IPF patients consisting of individuals with symptoms of GERD (34%), a history of GERD (45%), reported use of GERD medications (47%), and Nissen fundoplication (5%). After the multivariate adjustment, the use of GERD medication was associated with a lower radiologic fibrotic score. It was also an independent predictor of longer survival time in patients with IPF [41]. Lee JS et al. also reported the combined results of 3 prospectively collected randomized controlled trial data, including 242 patients only from the placebo arm. Although the data came from RCTs, this was not an RCT. Of the total 242 patients, 124 patients were taking PPI/H2RA, and 118 patients were not taking any antisecretory therapy. In IPF, a slower decline in Forced vital capacity (FVC) has shown a correlation with improved survival time in IPF [42]. The study showed that there was a slower decline in FVC in the PPI/H2RA group, which was statistically significant. Also, there were fewer acute exacerbations in the PPI/H2RA group, and this result did not contribute to the slower decline in FVC. However, there was no change in mortality, presumably due to the follow-up period not being sufficient. This study result generated an interesting hypothesis that the use of PPI/H2RA could slow disease progression [43].
Furthermore, Fidler et al. conducted a systematic review and meta-analysis, studying the effect of pharmacological therapy of GERD in IPF patients, which showed a significant improvement in IPF related survival (adjusted risk: HR 0.45) but no effect on all-cause mortality. There was a change in progression-free survival, FVC, acute exacerbation, and other Pulmonary function test parameters. In patients with FVC less than 70% of predicted, there was an increase in pulmonary infection, which was significant as this is a known side effect of PPI affecting patients with more advanced disease [44]. It follows from this discussion that the studies once again have small numbers, mostly observational, and hence have limitations providing poor or limited quality of evidence [44].
In a randomized controlled trial, Raghu et al. analyzed data from 27 patients who underwent Laparoscopic anti-reflux surgery (LARS) and 20 patients who did not undergo surgery with FVC measurement at 48 weeks as the endpoint in an intention to treat analysis. All patients had abnormal acid GER with a confirmed DeMeester score of ≥14·7; measured by 24-h pH monitoring and preserved forced vital capacity (FVC) of more than 50%. Patients were allowed to use Nintedanib and Pirfenidone. Patients in the surgery group had a slower decline in FVC, which was not statistically significant at 48 weeks in the non-surgery group (p = 0·28)}. Acute exacerbation of IPF, hospitalization for respiratory etiology, and mortality were also less in the surgical group, however not to statistical significance [45].
GERD has been known to be co-existent with many Pulmonary disorders such as Systemic Sclerosis, Chronic obstructive pulmonary disease (COPD), Bronchial Asthma, IPF, Bronchiectasis, Aspiration Pneumonia, Lung transplant complications such as Bronchiolitis obliterans (BOS), etc. [6]. These plethora’s of lung conditions being associated with GERD are likely due to the shared common genetic embryological and developmental origin of the two organ systems from the foregut [6, 60]. In addition, they share the intrathoracic cavity and also have the same vagal innervation [6, 60]. As such, two predominant theories are in vogue, the “Refluxate theory” and the “Reflux theory,” which attempt to explain the disease mechanisms with their common origin and development as background. The “Refluxate theory,” as previously described, implicates acid reflux from the GI tract and its micro-aspiration into the Respiratory tree, causing physicochemical damage to the latter culminating in fibrosis [6]. The “Reflex theory” pertains to the reflex increase in bronchoconstriction and airway resistance in response to the presence of acid in the esophagus and respiratory tree [6]. Furthermore, as discussed previously, the presence of pulmonary fibrosis may aggravate the gastroesophageal reflux due to decreased compliance, elasticity, and need for increased negative intrathoracic pressure generated during inspiration, causing increased gradient across thoracic and abdominal compartments [6]. Hence there is possibly a bidirectional relationship between the two organ systems, as depicted in Figure 1. A Summary of the studies that evaluated the role of antireflux therapy and surgery in the management of IPF is available in Table 1.
The bidirectional relationship between IPF and GERD.
Authors | Year | Study type | Anti-reflux therapy type | Population size | Outcomes |
---|---|---|---|---|---|
Cantu et al. [46] | 2004 | Retrospective cohort study | Fundoplication | 457 |
|
Raghu et al. [18] | 2006 | Case series | PPIs | 4 |
|
Linden et al. [47] | 2006 | Retrospective cohort study | Fundoplication | 45 |
|
Lee et al. [41] | 2011 | Retrospective cohort study | PPIs–H2RAs | 204 |
|
Fisichella et al. [48] | 2011 | Prospective study | LARS | 39 |
|
Noth et al. [10] | 2012 | Retrospective cohort study | PPIs–H2RAs | 74 |
|
Raghu et al. [49] | 2016 | Retrospective cohort study | LARS | 27 |
|
Lee et al. [43] | 2013 | Post hoc analysis of RCTs | PPIs–H2RAs | 242 |
|
Ghebremariam et al. [38] | 2015 | A retrospective analysis from 2 databases | PPIs | 215 |
|
Raghu et al. [37] | 2015 | Post hoc analysis of RCTs | PPIs–H2RAs | 1061 |
|
Kreuter et al. [50] | 2016 | PPIs–H2RAs | 624 |
| |
Lee et al. [51] | 2016 | Retrospective cohort study | PPIs | 786 |
|
Kreuter et al. [52] | 2016 | Retrospective cohort study | PPIs | 272 |
|
Elkstrom et al. [53] | 2016 | Prospective population-based study | PPIs–H2RAs | 462 |
|
Kulkarni et al. [54] | 2016 | Retrospective cohort study | PPIs–H2RAs | 284 |
|
Raghu et al. [55] | 2016 | Retrospective cohort study | LARS | 27 |
|
Kreuter et al. [56] | 2017 | Post hoc analysis of RCTs | PPIs–H2Ras | 632 |
|
Restivo et al. [57] | 2017 | Population-based study | PPIs–H2RAs | 6797 |
|
Raghu et al. [45] | 2018 | A prospective randomized controlled study | LARS | 58 |
|
Costabel et al. [58] | 2018 | PPIs–H2RAs | 406 |
| |
Helen et al. [59] | 2019 | A retrospective analysis from 1 database | PPIs–H2RAs | 587 |
|
Summary of the studies that evaluated the role of antireflux therapy and surgery in the management of IPF.
Abbreviations: BOS: bronchitis obliterans syndrome; PPIs: proton pump inhibitors; PFT: pulmonary function tests; H2RAs: H2 receptor antagonists; LARS: laparoscopic anti-reflux surgery; GERD: gastroesophageal reflux disease; IPF: idiopathic pulmonary fibrosis; DLCO: diffusion lung capacity for carbon monoxide; BALF: bronchoalveolar lavage fluid; RCTs: randomized controlled trials; FVC: forced vital capacity; ILD: interstitial lung disease; CI: confidence interval; HR: hazard ratio.
Studies designed to test the relationships between the two diseases entities have several limitations. They are mostly retrospective, have small sample sizes, with poorly defined inclusion and exclusion criteria, resulting in many confounders. While these limitations can be addressed partially by conducting prospective studies, randomized controlled data with a large sample size will remain elusive due to the prolonged time required for a disease process like IPF takes to evolve and manifest [25]. Besides, diseases like IPF are not clearly recognizable early, and GERD with non-acid reflux or poorly acidic reflux may not manifest with classic symptoms [6, 25], hence denying the opportunity for early recognition and follow up. Hence, our reliance on smaller case-controlled studies with a few well-conducted meta-analyses has only revealed an association between GERD and IPF, far from the nine causality criteria propounded by “Hill” [61, 62]. Although not ruling out causality, a weak association between the two diseases still needs to be viewed with an abundance of caution as the effects of residual confounding generate sufficient bias to prevent a robust causal inference from these types of studies [62]. Although such challenges will limit future studies, investigating therapeutic interventions like LARS and PPIs along with disease-modifying therapies like Nintedanib and Pirfenidone may improve outcomes for our IPF patients [25].
The large database-based clinical studies with robust timestamping of initiation of each disease entity will be helpful in establishing a temporal relationship. A machine learning model development is the need of the hour to answer this clinical question.
The co-existence of IPF and GERD is very common. There is likely a bidirectional pathophysiological relationship between the two disease entities. Although there is no causality established, current guidelines do recommend therapy with PPI in all patients with IPF. There remain many important challenges to the study of these coexisting conditions, and it may not be possible to obtain robust data establishing causality. Nevertheless, an attempt can be made to further conduct well-designed interventional studies to benefit patients in need.
Kristina Kardum Cvitan, Author Service Manager, IntechOpen.
The authors declare no conflict of interest.
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Assessing Hazards, Emergencies and Disaster Impacts"},signatures:"Jesús San-Miguel-Ayanz, Ernst Schulte, Guido Schmuck, Andrea Camia, Peter Strobl, Giorgio Liberta, Cristiano Giovando, Roberto Boca, Fernando Sedano, Pieter Kempeneers, Daniel McInerney, Ceri Withmore, Sandra Santos de Oliveira, Marcos Rodrigues, Tracy Durrant, Paolo Corti, Friderike Oehler, Lara Vilar and Giuseppe Amatulli",authors:[{id:"73894",title:"Dr.",name:"Jesús",middleName:null,surname:"San-Miguel-Ayanz",slug:"jesus-san-miguel-ayanz",fullName:"Jesús San-Miguel-Ayanz"},{id:"126055",title:"MSc.",name:"Ernst",middleName:null,surname:"Schulte",slug:"ernst-schulte",fullName:"Ernst Schulte"},{id:"126056",title:"Dr.",name:"Guido",middleName:null,surname:"Schmuck",slug:"guido-schmuck",fullName:"Guido Schmuck"},{id:"126057",title:"Dr.",name:"Andrea",middleName:null,surname:"Camia",slug:"andrea-camia",fullName:"Andrea Camia"},{id:"126058",title:"Dr.",name:"Peter",middleName:null,surname:"Strobl",slug:"peter-strobl",fullName:"Peter Strobl"},{id:"126059",title:"Mr.",name:"Giorgio",middleName:null,surname:"Liberta",slug:"giorgio-liberta",fullName:"Giorgio Liberta"},{id:"126060",title:"MSc.",name:"Cristiano",middleName:null,surname:"Giovando",slug:"cristiano-giovando",fullName:"Cristiano Giovando"},{id:"126061",title:"BSc.",name:"Roberto",middleName:null,surname:"Boca",slug:"roberto-boca",fullName:"Roberto Boca"},{id:"126062",title:"Dr.",name:"Fernando",middleName:null,surname:"Sedano",slug:"fernando-sedano",fullName:"Fernando Sedano"},{id:"126063",title:"Dr.",name:"Pieter",middleName:null,surname:"Kempeners",slug:"pieter-kempeners",fullName:"Pieter Kempeners"},{id:"126064",title:"Dr.",name:"Daniel",middleName:null,surname:"McInerney",slug:"daniel-mcinerney",fullName:"Daniel McInerney"},{id:"126066",title:"BSc.",name:"Ceri",middleName:null,surname:"Whitmore",slug:"ceri-whitmore",fullName:"Ceri Whitmore"},{id:"126068",title:"MSc.",name:"Sandra",middleName:null,surname:"Santos De Oliveira",slug:"sandra-santos-de-oliveira",fullName:"Sandra Santos De Oliveira"},{id:"126070",title:"MSc.",name:"Marcos",middleName:null,surname:"Rodrigues",slug:"marcos-rodrigues",fullName:"Marcos Rodrigues"},{id:"126072",title:"MSc.",name:"Tracy",middleName:null,surname:"Durrant",slug:"tracy-durrant",fullName:"Tracy Durrant"},{id:"126073",title:"MSc.",name:"Paolo",middleName:null,surname:"Corti",slug:"paolo-corti",fullName:"Paolo Corti"},{id:"126074",title:"MSc.",name:"Friderike",middleName:null,surname:"Oehler",slug:"friderike-oehler",fullName:"Friderike Oehler"},{id:"126075",title:"Dr.",name:"Lara",middleName:null,surname:"Vilar",slug:"lara-vilar",fullName:"Lara Vilar"},{id:"126076",title:"Dr.",name:"Giuseppe",middleName:null,surname:"Amatulli",slug:"giuseppe-amatulli",fullName:"Giuseppe Amatulli"}]},{id:"41478",doi:"10.5772/51387",title:"Monogenetic Basaltic Volcanoes: Genetic Classification, Growth, Geomorphology and Degradation",slug:"monogenetic-basaltic-volcanoes-genetic-classification-growth-geomorphology-and-degradation",totalDownloads:6189,totalCrossrefCites:72,totalDimensionsCites:142,abstract:null,book:{id:"3088",slug:"updates-in-volcanology-new-advances-in-understanding-volcanic-systems",title:"Updates in Volcanology",fullTitle:"Updates in Volcanology - 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Hundreds of thousand people lost their lives and loss of billions of dollars’ properties occurred in these disasters. Occurred medium or high-intensity magnitude earthquakes in last twenty years showed that these loses continue. For reinforced concrete (R/C) buildings, inappropriate design such as soft and weak stories, strong beam–weak column, short column, hammering, unconfined gable wall and in-plane/out-of-plane movement of the walls causes damages. These are the main reasons. In addition to this, low quality of structural materials, poor workmanship, lack of engineering services, and construction with insufficient detailing of the structural elements are the another reasons of damages. Main reasons of masonry building damages in terms of design faults can be shown as heavy earthen roofs, inappropriate detailing of wall to wall connection and wall to roof connection, absence of bond beams, large openings. However, construction of buildings by using local materials with poor workmanship on the base of traditional rules is the other reason of failures for these buildings. In this book chapter, earthquakes and reasons of damages arose from earthquakes for reinforced concrete and masonry structures were presented. In addition to this, appropriate solutions are suggested.",book:{id:"5499",slug:"earthquakes-tectonics-hazard-and-risk-mitigation",title:"Earthquakes",fullTitle:"Earthquakes - Tectonics, Hazard and Risk Mitigation"},signatures:"Burak Yön, Erkut Sayın and Onur Onat",authors:[{id:"192483",title:"Dr.",name:"Burak",middleName:null,surname:"Yön",slug:"burak-yon",fullName:"Burak Yön"},{id:"192486",title:"Dr.",name:"Erkut",middleName:null,surname:"Sayın",slug:"erkut-sayin",fullName:"Erkut Sayın"},{id:"192487",title:"Dr.",name:"Onur",middleName:null,surname:"Onat",slug:"onur-onat",fullName:"Onur Onat"}]},{id:"52565",doi:"10.5772/65511",title:"Earthquake Prediction",slug:"earthquake-prediction",totalDownloads:2046,totalCrossrefCites:11,totalDimensionsCites:21,abstract:"Among the countless natural disasters, earthquakes are capable to inflict vast devastation to a large number of buildings and constructions at the blink of an eye. Lack of knowledge and awareness on earthquake as well as its comeback is conspicuous and results in disaster; leading to bitter memories. Therefore, earthquake forecast has been a polemical study theme that has defied even the most intelligent of minds. In this chapter, an attempt was made to do an extensive overview in the area of the earthquake prediction as well as classifying them into the main strategies comprising short‐, immediate‐, and long‐term prediction. An example of each strategy was carried out by mentioning their corresponding approaches/algorithms, such as ΔCFS, CN, MSc, M8, ANN, FFBPANN, KNN, GRNN, RBF, and LMBP; depending on the importance of each strategy. Based on these, it was concluded that, after the Tohoku‐Oki earthquake with M9.0, the current orientation of the Headquarters for earthquake Research Promotion of MEXT in Japan declare that, their mission would be long‐term statistical forecast of seismicity. Even, it is claimed that they do not emphasize on short‐term forecasting. Besides, intermediate‐term estimations are not capable to be used for prevention of all damages and protect all human life, but they may be utilized to undertake certain affordable activities to decrease damage, losses, and modify postdisaster relief. And, despite the long‐term prediction is more concerned by researchers, there is no certain satisfactory level to content them. De facto, the made covenant of 1970 that investigators will be capable to forecast/predict ground excitations within a decade, still remains unmet.",book:{id:"5499",slug:"earthquakes-tectonics-hazard-and-risk-mitigation",title:"Earthquakes",fullTitle:"Earthquakes - Tectonics, Hazard and Risk Mitigation"},signatures:"Khaled Ghaedi and Zainah Ibrahim",authors:[{id:"190572",title:"Dr.",name:"Khaled",middleName:null,surname:"Ghaedi",slug:"khaled-ghaedi",fullName:"Khaled Ghaedi"},{id:"196228",title:"Prof.",name:"Zainah",middleName:null,surname:"Ibrahim",slug:"zainah-ibrahim",fullName:"Zainah Ibrahim"}]}],mostDownloadedChaptersLast30Days:[{id:"41664",title:"Volcanic Natural Resources and Volcanic Landscape Protection: An Overview",slug:"volcanic-natural-resources-and-volcanic-landscape-protection-an-overview",totalDownloads:3782,totalCrossrefCites:2,totalDimensionsCites:4,abstract:null,book:{id:"3088",slug:"updates-in-volcanology-new-advances-in-understanding-volcanic-systems",title:"Updates in Volcanology",fullTitle:"Updates in Volcanology - New Advances in Understanding Volcanic Systems"},signatures:"Jiaqi Liu, Jiali Liu, Xiaoyu Chen and Wenfeng Guo",authors:[{id:"60000",title:"Prof.",name:"Jiaqi",middleName:null,surname:"Liu",slug:"jiaqi-liu",fullName:"Jiaqi Liu"}]},{id:"31815",title:"Disaster Management Based on Business Process Model Through the Plant Lifecycle",slug:"disaster-management-based-on-business-process-model-through-the-plant-lifecycle",totalDownloads:2727,totalCrossrefCites:6,totalDimensionsCites:10,abstract:null,book:{id:"600",slug:"approaches-to-managing-disaster-assessing-hazards-emergencies-and-disaster-impacts",title:"Approaches to Managing Disaster",fullTitle:"Approaches to Managing Disaster - Assessing Hazards, Emergencies and Disaster Impacts"},signatures:"Yukiyasu Shimada, Teiji Kitajima, Tetsuo Fuchino and Kazuhiro Takeda",authors:[{id:"70197",title:"Dr.",name:"Yukiyasu",middleName:null,surname:"Shimada",slug:"yukiyasu-shimada",fullName:"Yukiyasu Shimada"},{id:"82055",title:"Dr.",name:"Tetsuo",middleName:null,surname:"Fuchino",slug:"tetsuo-fuchino",fullName:"Tetsuo Fuchino"},{id:"82056",title:"Prof.",name:"Teiji",middleName:null,surname:"Kitajima",slug:"teiji-kitajima",fullName:"Teiji Kitajima"},{id:"121284",title:"Dr.",name:"Kazuhiro",middleName:null,surname:"Takeda",slug:"kazuhiro-takeda",fullName:"Kazuhiro Takeda"}]},{id:"52524",title:"Earthquakes and Structural Damages",slug:"earthquakes-and-structural-damages",totalDownloads:3388,totalCrossrefCites:14,totalDimensionsCites:21,abstract:"Earthquakes are the most destructive natural hazards throughout human history. Hundreds of thousand people lost their lives and loss of billions of dollars’ properties occurred in these disasters. Occurred medium or high-intensity magnitude earthquakes in last twenty years showed that these loses continue. For reinforced concrete (R/C) buildings, inappropriate design such as soft and weak stories, strong beam–weak column, short column, hammering, unconfined gable wall and in-plane/out-of-plane movement of the walls causes damages. These are the main reasons. In addition to this, low quality of structural materials, poor workmanship, lack of engineering services, and construction with insufficient detailing of the structural elements are the another reasons of damages. Main reasons of masonry building damages in terms of design faults can be shown as heavy earthen roofs, inappropriate detailing of wall to wall connection and wall to roof connection, absence of bond beams, large openings. However, construction of buildings by using local materials with poor workmanship on the base of traditional rules is the other reason of failures for these buildings. In this book chapter, earthquakes and reasons of damages arose from earthquakes for reinforced concrete and masonry structures were presented. In addition to this, appropriate solutions are suggested.",book:{id:"5499",slug:"earthquakes-tectonics-hazard-and-risk-mitigation",title:"Earthquakes",fullTitle:"Earthquakes - Tectonics, Hazard and Risk Mitigation"},signatures:"Burak Yön, Erkut Sayın and Onur Onat",authors:[{id:"192483",title:"Dr.",name:"Burak",middleName:null,surname:"Yön",slug:"burak-yon",fullName:"Burak Yön"},{id:"192486",title:"Dr.",name:"Erkut",middleName:null,surname:"Sayın",slug:"erkut-sayin",fullName:"Erkut Sayın"},{id:"192487",title:"Dr.",name:"Onur",middleName:null,surname:"Onat",slug:"onur-onat",fullName:"Onur Onat"}]},{id:"41478",title:"Monogenetic Basaltic Volcanoes: Genetic Classification, Growth, Geomorphology and Degradation",slug:"monogenetic-basaltic-volcanoes-genetic-classification-growth-geomorphology-and-degradation",totalDownloads:6195,totalCrossrefCites:71,totalDimensionsCites:142,abstract:null,book:{id:"3088",slug:"updates-in-volcanology-new-advances-in-understanding-volcanic-systems",title:"Updates in Volcanology",fullTitle:"Updates in Volcanology - New Advances in Understanding Volcanic Systems"},signatures:"Gábor Kereszturi and Károly Németh",authors:[{id:"51162",title:"Dr.",name:"Károly",middleName:null,surname:"Németh",slug:"karoly-nemeth",fullName:"Károly Németh"},{id:"62029",title:"Dr.",name:"Gabor",middleName:null,surname:"Kereszturi",slug:"gabor-kereszturi",fullName:"Gabor Kereszturi"}]},{id:"62769",title:"Disaster Mitigation Model of Eruption Based on Local Wisdom in Indonesia",slug:"disaster-mitigation-model-of-eruption-based-on-local-wisdom-in-indonesia",totalDownloads:1462,totalCrossrefCites:1,totalDimensionsCites:2,abstract:"Kelud is one of the most active volcanoes in Indonesia and suffered a major eruption in 2014. Although they are not part of the super volcano, the impact of the eruption is extraordinary. However, the eruption is not too worrying for the surrounding community. The lack of disaster victims caused by the eruption in 2014 became a successful representation of disaster mitigation models owned by local communities in answering the eruption problem. The easy evacuation process and quickly post-eruption rehabilitation illustrate a pattern of environmental adaptation around the volcano. This discussion focuses on how the people behavior around the volcano in responding to the challenge of eruption? How the role of local government in preparing the community in the face of an eruption, and what actions are done so that the rehabilitation process can take place quickly? To answer all these questions, the researchers collected relevant data through observation, documentation, and interviews with the local communities and local government representatives directly involved in disaster mitigation measures. In addition, the researchers also revealed local traditions that are considered capable of supporting the process of preparing the community in answering the eruption challenges and becoming part of disaster mitigation in the volcanic region.",book:{id:"6821",slug:"natural-hazards-risk-assessment-and-vulnerability-reduction",title:"Natural Hazards",fullTitle:"Natural Hazards - Risk Assessment and Vulnerability Reduction"},signatures:"Eko Hariyono and Solaiman Liliasari",authors:[{id:"214360",title:"Dr.",name:"Eko",middleName:null,surname:"Hariyono",slug:"eko-hariyono",fullName:"Eko Hariyono"},{id:"219699",title:"Prof.",name:"Liliasari",middleName:null,surname:"S",slug:"liliasari-s",fullName:"Liliasari S"}]}],onlineFirstChaptersFilter:{topicId:"106",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"81241",title:"Physiological and Molecular Adaptation of Sugarcane under Drought vis-a-vis Root System Traits",slug:"physiological-and-molecular-adaptation-of-sugarcane-under-drought-vis-a-vis-root-system-traits",totalDownloads:21,totalDimensionsCites:0,doi:"10.5772/intechopen.103795",abstract:"Among various abiotic stresses, water is reported as a rare entity in many parts of the world. Decreased frequency of precipitation and global temperature rise will further aggravate the situation in future. Being C4 plant, sugarcane requires generous water for the proper growth. Plant root system primarily supports above-ground growth by anchoring in the soil and facilitates water and nutrients uptake from the soil. The plasticity and dynamic nature of roots endow plants for the uptake of vital nutrients from the soil even under soil moisture conditions. In sugarcane, the major part of root system are generally observed in the upper soil layers, while limited water availability shifts the root growth towards the lower soil layer to sustained water uptake. In addition, root traits are directly related to physiological traits of the shoot to cope up with water limited situations via reduction in stomatal conductance and an upsurge in density and deep root traits, adaptations at biochemical and molecular level which includes osmotic adjustment and ROS detoxification. Under stressed conditions, these complex interactive systems adjust homeo-statically to minimize the adverse impacts of stress and sustain balanced metabolism. Therefore, the present chapter deals with physiological and biochemical traits along with root traits that helps for better productivity of sugarcane under water-limited conditions.",book:{id:"11131",title:"Drought - Impacts and Management",coverURL:"https://cdn.intechopen.com/books/images_new/11131.jpg"},signatures:"Pooja Dhansu, Arun Kumar Raja, Krishnapriya Vengavasi, Ravinder Kumar, Adhini S. Pazhany, Ashwani Kumar, Naresh Kumar, Anita Mann and Shashi Kant Pandey"},{id:"79973",title:"Impacts of Drought on Homestead Plant Diversity in Barind Tract of Bangladesh",slug:"impacts-of-drought-on-homestead-plant-diversity-in-barind-tract-of-bangladesh",totalDownloads:6,totalDimensionsCites:0,doi:"10.5772/intechopen.101885",abstract:"Homestead is a great place for household food access, diet, and nutrition. Drought affects homestead plant diversity and reduces production, availability, and diversity that lead toward less supply and consumption. Drought detains moisture and degrades the soil that supports plant growth. Homestead provides regular bread and income in the rural areas with an effective means for both economic and environmental well-being. People are getting a good amount of subsidiary income without any extra care and effort. In managing homestead land and drought, the household needs necessary technical and managerial training. In reducing drought effects to the homestead, action research needs to be carried out on available knowledge, effective practices, water management, and the adoption of local varieties and knowledge to develop effective homestead integration. Government initiatives, community engagement and not harming the environment, and efficient uses of water could be great solutions for the adverse effects of drought on the homestead plant diversity.",book:{id:"11131",title:"Drought - Impacts and Management",coverURL:"https://cdn.intechopen.com/books/images_new/11131.jpg"},signatures:"Md. Shafiqul Islam and Md. Nazrul Islam Mukul"},{id:"82110",title:"Hydrological Drought Index Based on Discharge",slug:"hydrological-drought-index-based-on-discharge",totalDownloads:28,totalDimensionsCites:0,doi:"10.5772/intechopen.104625",abstract:"Drought is a natural phenomenon causing disasters and its period of occurrence can be predicted in recent times based on several methods using the same or different variables. The prediction is usually associated with the climate interactions in the form of rainfall or discharge patterns which can be analyzed using the return period. Therefore, this research was conducted in four different stages of data acquisition and validation, drought analysis method based on the data, drought prediction method based on hydrology, and sample applications to determine the debit availability in other watersheds. Historical rainfall data converted to dependable rainfall at 80% probability were used as input for the rainfall-discharge analysis while the hydrological drought analysis was conducted using the drought threshold value. Moreover, the drought was predicted using an artificial neural network model while historical data were used to verify the hydrological character of the prediction model. The results of the analysis conducted were further used to predict the water balance in different river areas due to the fact that each area has a different hydrological character. Meanwhile, the watersheds used as case research showed that the model has reliability of up to 80%.",book:{id:"11131",title:"Drought - Impacts and Management",coverURL:"https://cdn.intechopen.com/books/images_new/11131.jpg"},signatures:"R. Rintis Hadiani, Bambang Suharto, Agus Suharyanto and Suhardjono"},{id:"81203",title:"Climate Change: A Real Danger to Human and Animal Survival",slug:"climate-change-a-real-danger-to-human-and-animal-survival",totalDownloads:42,totalDimensionsCites:0,doi:"10.5772/intechopen.103022",abstract:"Some countries in Southern Africa where hit by either a storm or cyclone or both in 2019 alone manifesting a changing climate. Infrastructure and cropping land was destroyed, both animal and human lives were lost due to the flooding events. Drought is a common phenomenon in this region, often occurring once in three years. This has affected food, feed and nutritional security of both humans and livestock. Saline soils unsuitable for agriculture, other animal and plant life are expanding fast due to insufficient precipitation. Soil degradation is on the rise, leaving soils with poor water holding capacity to support sustainable agriculture. Climate change is changing the environment and new pests and diseases for both crops and livestock are emerging. World governments, industries and general populace should find better ways of reducing air pollution by greenhouse gases which have a net effect of damaging the ozone layer and increasing atmospheric temperatures. At the same time, plant and animal breeding should aim at improving crop cultivars and animal breeds that resist to the constraints such as drought and heat stress brought by climate change. The human population is increasing at an alarming rate and need both food and nutritional security.",book:{id:"11131",title:"Drought - Impacts and Management",coverURL:"https://cdn.intechopen.com/books/images_new/11131.jpg"},signatures:"Godwill Makunde, Nation Chikumba, Walter Svinurai and Xavier Mhike"},{id:"81810",title:"Water Shortages: Cause of Water Safety in Sub-Saharan Africa",slug:"water-shortages-cause-of-water-safety-in-sub-saharan-africa",totalDownloads:25,totalDimensionsCites:0,doi:"10.5772/intechopen.103927",abstract:"This chapter highlights a high rate of water crisis across sub-Saharan Africa (SSA) despite its huge hydro-potential. Factors contributing to water stress include rainfall deficit and drought, increased water requirements, population growth, urbanization, and poverty. Coupled with the uneven distribution of water resources and mismanagement of water facilities, the gap between the demand for water and available supply has deepened. This has led almost half of the SSA population to drink water from unprotected sources. Moreover, many millions travel far distances and spend several hours daily to collect water. Children and women are mainly involved in water collection. The growing scarcity of water in Africa has a negative impact on economic growth. Besides, water shortages are at the heart of many social crises in SSA and have become directly or indirectly the first cause of death in Africa linked to waterborne diseases. The prevailing water-related diseases include malaria, typhoid fever, cholera, poliomyelitis, etc. To attain the African agenda 2063, national governments in SSA need a multidisciplinary approach integrating, supervising informal settlements of the population in urban and peri-urban areas; improving water storage capacity; increasing irrigation potential for agriculture; and having a good understanding of the epidemiology of waterborne diseases.",book:{id:"11131",title:"Drought - Impacts and Management",coverURL:"https://cdn.intechopen.com/books/images_new/11131.jpg"},signatures:"Chelea Matchawe, Patrice Bonny, Germaine Yandang, Huguette Cecile Yangoua Mafo and Bonglaisin J. Nsawir"},{id:"81584",title:"Reducing the Effects of Drought and Degradation of Agricultural Soils, in the Context of Climate Change, through the Application of Regenerative Ecological Technologies",slug:"reducing-the-effects-of-drought-and-degradation-of-agricultural-soils-in-the-context-of-climate-chan",totalDownloads:41,totalDimensionsCites:0,doi:"10.5772/intechopen.104446",abstract:"The agricultural sector has a limited capacity for expansion, consequently, deficient technologies based on the widespread use of synthetic chemicals have been implemented in the last decades, having a major negative impact on natural ecosystems, biodiversity, and environmental services. Desertification, land degradation, and drought, combined with human activity and environmental changes, cause important soil losses and a reduction in natural defenses against droughts and floods. The combined impact of climate change, land mismanagement and unsustainable freshwater use has long been affecting agricultural productivity, the most common cause being unsustainable land management practices. This chapter aims to briefly assess the most effective strategies for reducing the impact of climate change on agricultural crops, as well as to prevent or reverse the process of desertification and systematic loss in food quality and quantity. Regenerative management practices such as minimum tillage technologies, cover crops and mulching, inoculation with microorganisms, nutrients cycling, the balance of the organic fertilizers or foliar application help farmers in managing healthy soils, capable of growing rich and ecological crops without the use of chemical hazardous substances.",book:{id:"11131",title:"Drought - Impacts and Management",coverURL:"https://cdn.intechopen.com/books/images_new/11131.jpg"},signatures:"Eugen Popescu, Florin Nenciu and Valentin Nicolae Vladut"}],onlineFirstChaptersTotal:9},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:139,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:122,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:21,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:10,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"6",title:"Infectious Diseases",doi:"10.5772/intechopen.71852",issn:"2631-6188",scope:"This series will provide a comprehensive overview of recent research trends in various Infectious Diseases (as per the most recent Baltimore classification). Topics will include general overviews of infections, immunopathology, diagnosis, treatment, epidemiology, etiology, and current clinical recommendations for managing infectious diseases. Ongoing issues, recent advances, and future diagnostic approaches and therapeutic strategies will also be discussed. This book series will focus on various aspects and properties of infectious diseases whose deep understanding is essential for safeguarding the human race from losing resources and economies due to pathogens.",coverUrl:"https://cdn.intechopen.com/series/covers/6.jpg",latestPublicationDate:"August 2nd, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:13,editor:{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",biography:"Dr. Rodriguez-Morales is an expert in tropical and emerging diseases, particularly zoonotic and vector-borne diseases (especially arboviral diseases). He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"3",title:"Bacterial Infectious Diseases",coverUrl:"https://cdn.intechopen.com/series_topics/covers/3.jpg",isOpenForSubmission:!0,editor:{id:"205604",title:"Dr.",name:"Tomas",middleName:null,surname:"Jarzembowski",slug:"tomas-jarzembowski",fullName:"Tomas Jarzembowski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKriQAG/Profile_Picture_2022-06-16T11:01:31.jpg",biography:"Tomasz Jarzembowski was born in 1968 in Gdansk, Poland. He obtained his Ph.D. degree in 2000 from the Medical University of Gdańsk (UG). After specialization in clinical microbiology in 2003, he started studying biofilm formation and antibiotic resistance at the single-cell level. In 2015, he obtained his D.Sc. degree. His later study in cooperation with experts in nephrology and immunology resulted in the designation of the new diagnostic method of UTI, patented in 2017. He is currently working at the Department of Microbiology, Medical University of Gdańsk (GUMed), Poland. Since many years, he is a member of steering committee of Gdańsk branch of Polish Society of Microbiologists, a member of ESCMID. He is also a reviewer and a member of editorial boards of a number of international journals.",institutionString:"Medical University of Gdańsk, Poland",institution:null},editorTwo:{id:"484980",title:"Dr.",name:"Katarzyna",middleName:null,surname:"Garbacz",slug:"katarzyna-garbacz",fullName:"Katarzyna Garbacz",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003St8TAQAZ/Profile_Picture_2022-07-07T09:45:16.jpg",biography:"Katarzyna Maria Garbacz, MD, is an Associate Professor at the Medical University of Gdańsk, Poland and she is head of the Department of Oral Microbiology of the Medical University of Gdańsk. She has published more than 50 scientific publications in peer-reviewed journals. She has been a project leader funded by the National Science Centre of Poland. Prof. Garbacz is a microbiologist working on applied and fundamental questions in microbial epidemiology and pathogenesis. Her research interest is in antibiotic resistance, host-pathogen interaction, and therapeutics development for staphylococcal pathogens, mainly Staphylococcus aureus, which causes hospital-acquired infections. Currently, her research is mostly focused on the study of oral pathogens, particularly Staphylococcus spp.",institutionString:"Medical University of Gdańsk, Poland",institution:null},editorThree:null},{id:"4",title:"Fungal Infectious Diseases",coverUrl:"https://cdn.intechopen.com/series_topics/covers/4.jpg",isOpenForSubmission:!0,editor:{id:"174134",title:"Dr.",name:"Yuping",middleName:null,surname:"Ran",slug:"yuping-ran",fullName:"Yuping Ran",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bS9d6QAC/Profile_Picture_1630330675373",biography:"Dr. Yuping Ran, Professor, Department of Dermatology, West China Hospital, Sichuan University, Chengdu, China. Completed the Course Medical Mycology, the Centraalbureau voor Schimmelcultures (CBS), Fungal Biodiversity Centre, Netherlands (2006). International Union of Microbiological Societies (IUMS) Fellow, and International Emerging Infectious Diseases (IEID) Fellow, Centers for Diseases Control and Prevention (CDC), Atlanta, USA. Diploma of Dermatological Scientist, Japanese Society for Investigative Dermatology. Ph.D. of Juntendo University, Japan. Bachelor’s and Master’s degree, Medicine, West China University of Medical Sciences. Chair of Sichuan Medical Association Dermatology Committee. General Secretary of The 19th Annual Meeting of Chinese Society of Dermatology and the Asia Pacific Society for Medical Mycology (2013). In charge of the Annual Medical Mycology Course over 20-years authorized by National Continue Medical Education Committee of China. Member of the board of directors of the Asia-Pacific Society for Medical Mycology (APSMM). Associate editor of Mycopathologia. Vice-chief of the editorial board of Chinses Journal of Mycology, China. Board Member and Chair of Mycology Group of Chinese Society of Dermatology.",institutionString:null,institution:{name:"Sichuan University",institutionURL:null,country:{name:"China"}}},editorTwo:null,editorThree:null},{id:"5",title:"Parasitic Infectious Diseases",coverUrl:"https://cdn.intechopen.com/series_topics/covers/5.jpg",isOpenForSubmission:!0,editor:{id:"67907",title:"Dr.",name:"Amidou",middleName:null,surname:"Samie",slug:"amidou-samie",fullName:"Amidou Samie",profilePictureURL:"https://mts.intechopen.com/storage/users/67907/images/system/67907.jpg",biography:"Dr. Amidou Samie is an Associate Professor of Microbiology at the University of Venda, in South Africa, where he graduated for his PhD in May 2008. He joined the Department of Microbiology the same year and has been giving lectures on topics covering parasitology, immunology, molecular biology and industrial microbiology. He is currently a rated researcher by the National Research Foundation of South Africa at category C2. He has published widely in the field of infectious diseases and has overseen several MSc’s and PhDs. His research activities mostly cover topics on infectious diseases from epidemiology to control. His particular interest lies in the study of intestinal protozoan parasites and opportunistic infections among HIV patients as well as the potential impact of childhood diarrhoea on growth and child development. He also conducts research on water-borne diseases and water quality and is involved in the evaluation of point-of-use water treatment technologies using silver and copper nanoparticles in collaboration with the University of Virginia, USA. He also studies the use of medicinal plants for the control of infectious diseases as well as antimicrobial drug resistance.",institutionString:null,institution:{name:"University of Venda",institutionURL:null,country:{name:"South Africa"}}},editorTwo:null,editorThree:null},{id:"6",title:"Viral Infectious Diseases",coverUrl:"https://cdn.intechopen.com/series_topics/covers/6.jpg",isOpenForSubmission:!0,editor:{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. 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He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}},editorTwo:null,editorThree:null}]},overviewPageOFChapters:{paginationCount:19,paginationItems:[{id:"82804",title:"Psychiatric Problems in HIV Care",doi:"10.5772/intechopen.106077",signatures:"Seggane Musisi and Noeline Nakasujja",slug:"psychiatric-problems-in-hiv-care",totalDownloads:1,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Future Opportunities and Tools for Emerging Challenges for HIV/AIDS Control",coverURL:"https://cdn.intechopen.com/books/images_new/11575.jpg",subseries:{id:"6",title:"Viral Infectious Diseases"}}},{id:"82827",title:"Epidemiology and Control of Schistosomiasis",doi:"10.5772/intechopen.105170",signatures:"Célestin Kyambikwa Bisangamo",slug:"epidemiology-and-control-of-schistosomiasis",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"New Horizons for Schistosomiasis Research",coverURL:"https://cdn.intechopen.com/books/images_new/10829.jpg",subseries:{id:"5",title:"Parasitic Infectious Diseases"}}},{id:"82817",title:"Perspective Chapter: Microfluidic Technologies for On-Site Detection and Quantification of Infectious Diseases - The Experience with SARS-CoV-2/COVID-19",doi:"10.5772/intechopen.105950",signatures:"Andres Escobar and Chang-qing Xu",slug:"perspective-chapter-microfluidic-technologies-for-on-site-detection-and-quantification-of-infectious",totalDownloads:2,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"SARS-CoV-2 Variants - Two Years After",coverURL:"https://cdn.intechopen.com/books/images_new/11573.jpg",subseries:{id:"6",title:"Viral Infectious Diseases"}}},{id:"82667",title:"Perspective Chapter: Analysis of SARS-CoV-2 Indirect Spreading Routes and Possible Countermeasures",doi:"10.5772/intechopen.105914",signatures:"Cesare Saccani, Marco Pellegrini and Alessandro Guzzini",slug:"perspective-chapter-analysis-of-sars-cov-2-indirect-spreading-routes-and-possible-countermeasures",totalDownloads:8,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"SARS-CoV-2 Variants - Two Years After",coverURL:"https://cdn.intechopen.com/books/images_new/11573.jpg",subseries:{id:"6",title:"Viral Infectious Diseases"}}}]},overviewPagePublishedBooks:{paginationCount:13,paginationItems:[{type:"book",id:"6667",title:"Influenza",subtitle:"Therapeutics and Challenges",coverURL:"https://cdn.intechopen.com/books/images_new/6667.jpg",slug:"influenza-therapeutics-and-challenges",publishedDate:"September 19th 2018",editedByType:"Edited by",bookSignature:"Shailendra K. Saxena",hash:"105e347b2d5dbbe6b593aceffa051efa",volumeInSeries:1,fullTitle:"Influenza - Therapeutics and Challenges",editors:[{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}}]},{type:"book",id:"7064",title:"Current Perspectives in Human Papillomavirus",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7064.jpg",slug:"current-perspectives-in-human-papillomavirus",publishedDate:"May 2nd 2019",editedByType:"Edited by",bookSignature:"Shailendra K. Saxena",hash:"d92a4085627bab25ddc7942fbf44cf05",volumeInSeries:2,fullTitle:"Current Perspectives in Human Papillomavirus",editors:[{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}}]},{type:"book",id:"7123",title:"Current Topics in Neglected Tropical Diseases",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7123.jpg",slug:"current-topics-in-neglected-tropical-diseases",publishedDate:"December 4th 2019",editedByType:"Edited by",bookSignature:"Alfonso J. 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We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics can include but are not limited to: Biotechnology such as biotechnological products and process engineering; Biotechnologically relevant enzymes and proteins; Bioenergy and biofuels; Applied genetics and molecular biotechnology; Genomics, transcriptomics, proteomics; Applied microbial and cell physiology; Environmental biotechnology; Methods and protocols. Moreover, topics in biosensor technology, like sensors that incorporate enzymes, antibodies, nucleic acids, whole cells, tissues and organelles, and other biological or biologically inspired components will be considered, and topics exploring transducers, including those based on electrochemical and optical piezoelectric, thermal, magnetic, and micromechanical elements. Chapters exploring biomaterial approaches such as polymer synthesis and characterization, drug and gene vector design, biocompatibility, immunology and toxicology, and self-assembly at the nanoscale, are welcome. Finally, the tissue engineering subcategory will support topics such as the fundamentals of stem cells and progenitor cells and their proliferation, differentiation, bioreactors for three-dimensional culture and studies of phenotypic changes, stem and progenitor cells, both short and long term, ex vivo and in vivo implantation both in preclinical models and also in clinical trials.",annualVolume:11405,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/9.jpg",editor:{id:"126286",title:"Dr.",name:"Luis",middleName:"Jesús",surname:"Villarreal-Gómez",fullName:"Luis Villarreal-Gómez",profilePictureURL:"https://mts.intechopen.com/storage/users/126286/images/system/126286.jpg",institutionString:null,institution:{name:"Autonomous University of Baja California",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"35539",title:"Dr.",name:"Cecilia",middleName:null,surname:"Cristea",fullName:"Cecilia Cristea",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYQ65QAG/Profile_Picture_1621007741527",institutionString:null,institution:{name:"Iuliu Hațieganu University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"40735",title:"Dr.",name:"Gil",middleName:"Alberto Batista",surname:"Gonçalves",fullName:"Gil Gonçalves",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYRLGQA4/Profile_Picture_1628492612759",institutionString:null,institution:{name:"University of Aveiro",institutionURL:null,country:{name:"Portugal"}}},{id:"211725",title:"Associate Prof.",name:"Johann F.",middleName:null,surname:"Osma",fullName:"Johann F. 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