\r\n\tNanozymes are nanomaterials that resemble enzymes in appearance. They're a crucial link between nanomaterials and biological systems. Many nanozymes are modeled after natural enzymes like catalase and peroxidase, but future research will lead to the invention of unique artificial enzymes at the nanoscale. Nanozymes are currently being used in biomedicine to detect small biomolecules, metal ions, and cancer cells, among other targets. Nanozymes have a variety of advantages over natural enzymes. They're less expensive and can be recycled. Nanozymes are also inexpensive because they are simple to make and store for lengthy periods of time. Inorganic enzymes typically demand high temperatures, high pressures, and pH extremes. Nanozymes, on the other hand, may act in more physiological contexts and respond to a variety of external stimuli. The most significant benefit is the size- and/or composition-dependent display of activity, which means nanozymes can be produced with a wide range of catalytic activity merely by changing shape, structure, and composition. Nanozymes are also different from other artificial enzymes in that they have several integrated activities that aren't related to catalysis. Nanoscale materials have huge surface areas, making it easier to modify and bioconjugate them. The ability to self-assemble also resembles a key biological strategy, allowing biological components to be easily assimilated. Nanozymes can be used for a variety of purposes, including diagnostic medicine, targeted therapy, and biosensing. It's critical to be able to diagnose the disease early on in order to enhance clinical outcomes. Nanozymes are being used to create biosensors that are rapid, dependable, and very sensitive.
\r\n\r\n\tThe purpose of this book is to review the experimental and scientific advances that have been made in the simulation, design, and application of nanozymes in the last decade.
",isbn:"978-1-80356-666-5",printIsbn:"978-1-80356-665-8",pdfIsbn:"978-1-80356-667-2",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!1,isSalesforceBook:!1,isNomenclature:!1,hash:"7d040dd70e3021d1c7da668be1263616",bookSignature:"D.Sc. Rafael Vargas-Bernal",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11754.jpg",keywords:"Synthetic Organic Molecules or Ions, Enzyme Catalysis, Biomimetics, Optical, Thermal, Density Functional Theory, First-Principles Study, Biological and Chemical Behavior, Biosensors, Antioxidation, Food Industry, Safety Detection",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"March 22nd 2022",dateEndSecondStepPublish:"May 24th 2022",dateEndThirdStepPublish:"July 23rd 2022",dateEndFourthStepPublish:"October 11th 2022",dateEndFifthStepPublish:"December 10th 2022",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"3 months",secondStepPassed:!0,areRegistrationsClosed:!0,currentStepOfPublishingProcess:4,editedByType:null,kuFlag:!1,biosketch:"A pioneer in the development of applied nanomaterials in aeronautics, electronics, and medicine in Mexico, a professor with a desirable PRODEP profile, and a member of the National System of Researchers in Mexico (level 1).",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"182114",title:"D.Sc.",name:"Rafael",middleName:null,surname:"Vargas-Bernal",slug:"rafael-vargas-bernal",fullName:"Rafael Vargas-Bernal",profilePictureURL:"https://mts.intechopen.com/storage/users/182114/images/system/182114.jpeg",biography:"Rafael Vargas-Bernal received a bachelor's degree in Communications and Electronics Engineering from the University of Guanajuato in 1995, and the degrees of Master of Science and Doctorate in Sciences with Specialty in Electronics from the National Institute of Astrophysics, Optics and Electronics (INAOE) in 1997 and 2000, respectively. Since January 2002, he has been a professor-researcher at the Higher Technological Institute of Irapuato (ITESI) and, particularly since 2006, he has worked in the Department of Materials Engineering where he has established himself as a senior researcher. He has authored 1 book, 16 articles in journals, 42 chapters in books, and about 150 conference articles. He is a member of the National System of Researchers (SNI-Mexico). He regularly serves as a reviewer of scientific articles in RSC Advances, Royal Society Open Science, Materials Science and Engineering B, New Journal of Chemistry, Sensors and Actuators B: Chemical, Applied Surface Science, Journal of Alloys and Compounds, Materials Today Communications, Sensors, Aggregate, Advances in Polymer Technology, Advances in Materials Science and Engineering, IET Circuits, Devices and Systems, Nanoscale, SoftwareX, IEEE Electron Device Letters, IEEE Transactions on Nanotechnology, as well as reviewer of standards in Semiconductor Equipment and Materials International (SEMI). 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Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact."}},relatedBooks:[{type:"book",id:"9322",title:"Hybrid Nanomaterials",subtitle:"Flexible Electronics Materials",isOpenForSubmission:!1,hash:"beff6cce44f54582ee8a828759d24f19",slug:"hybrid-nanomaterials-flexible-electronics-materials",bookSignature:"Rafael Vargas-Bernal, Peng He and Shuye Zhang",coverURL:"https://cdn.intechopen.com/books/images_new/9322.jpg",editedByType:"Edited by",editors:[{id:"182114",title:"D.Sc.",name:"Rafael",surname:"Vargas-Bernal",slug:"rafael-vargas-bernal",fullName:"Rafael Vargas-Bernal"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5884",title:"Unraveling the Safety Profile of Nanoscale Particles and Materials",subtitle:"From Biomedical to Environmental Applications",isOpenForSubmission:!1,hash:"5e5811aa0f15ab9d8b6a235e8408875d",slug:"unraveling-the-safety-profile-of-nanoscale-particles-and-materials-from-biomedical-to-environmental-applications",bookSignature:"Andreia C. 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Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"57258",title:"Sound Waves in Complex (Dusty) Plasmas",doi:"10.5772/intechopen.71203",slug:"sound-waves-in-complex-dusty-plasmas",body:'\nTransport properties of complex dusty plasma have been very actively investigated in the laboratory and by computer simulations, and wave properties have played a dominated role in both system monitoring and optimization. Waves in complex system have a dynamical role for understanding the behaviours of individual particles in different applications, for example, instabilities and wave propagation during flow. The subject of complex liquids or dusty plasmas containing micron-size charged condensed particles has recently been actively investigated in the physics and chemistry of plasmas, ionized gases, and the space environment, environmental sciences, semiconductor plasma processing industries, nuclear energy generation and materials research. Dust in atmosphere and in the entire universe is in different shapes and sizes. Mostly, it is in solid form and also in liquid and gaseous forms. Dust particle coexists with plasma and then forms dusty (complex) plasma. In the plasma when an electron is displaced from their equilibrium position, the electrostatic forces due to ions pull the electron back. Due to small mass of electron, overshoot the ions and oscillation in plasma is started.
\nThere are four states of matter: liquid, solid, gas and plasma. The Irving Langmuir, an American physicist, defines plasma first time as “plasma is a quasi-neutral gas of the charged particles that show collective behaviors.” He received Noble prize in 1927 first time using the term “plasma” [1]. The quasi neutral means “when the number of ions is equal to the number of electrons then gas becomes electrically neutral (
In 1922, the term plasma is used and defined by an American scientist Irving Langmuir. In 1930, a few isolated researchers, each motivated by some specific practical problems, began the study of what is now called plasma physics. In 1940, Hanes Alfven developed theory of hydrodynamic waves and gives the future prospectus of waves in astrophysical plasma (now called Alfven’s waves). In 1950, research on magnetic fusion energy was started based on plasma physics in the USA, Soviet and Britain. The end decade of 1960 Russian Tokomak configuration empirically developed and created plasma with different parameters. In 1970 and 1980, the performance of tokomak was improved at the end of twentieth century and fusion break-even nearly achieved in tokomak. In the 1980s, many new applications of plasma in different fields of science and technology appeared. In the 1990s, study on dusty plasma was started (when the dust particles are immersed in plasma, they change the properties of plasma, which is known as dusty plasma) [4, 5].
\nPlasma classified on the basis of temperature of electrons, ions and degree of ionization as well as density.
\nTi, Te and Tg are the temperatures of ions, electron and gas respectively, if the plasmas satisfy Te > > Ti > > Tg condition is called cold plasma. The pressure of the cold plasma is low than collisions between electrons, ions and gases molecule that are not frequent. In this plasma, non-thermal symmetry between energies of gas molecules and electrons are not existed. Temperature of electrons is higher than ions and has greater energy than ions. Similarly, ions have greater energy than gas molecules. In this type of plasma, the effect of magnetic field is very weak and also can be ignored; only charge particles are affected by electric field. It is created in the laboratory on positive column of the glow discharge tube. Applications of cold plasma in food processing, sterilization of tooth, hand and self-decontaminating filter. It is used as a convenient descriptor to distinguish one-atmosphere. Examples of cold plasma are fluorescent lamps and neon signs [6].
\nIf the plasma having very low temperature approximately 100 mK to 10 μK, density 2×109cm3, interaction between particles is strong and the thermal energy of the particles is low compared with Coulomb energy between interacting particles known as ultracold plasma. It is created by pulsed lasers, laser-cooled atoms and photo ionization [7].
\nIf the plasmas have very high temperature, the collision between interacting particles is very frequent also thermal equilibrium obtains, if plasma satisfies
It is defined by a plasma parameter which is known as Coulomb coupling and denoted by \n
When dust particles are immersed in the plasma, then the properties of plasma become complex known as complex (dusty) plasma. The dust particles are charged and much larger than electrons, ions and neutral atoms, and their size varies from millimetre to nanometre. The properties of dust particles are investigated in different fields of research such as plasma physics, plasma chemistry, ionized gases, material research and astrophysics and also in space physics. Dust particle changes different properties of plasma dominate in current carrier, form liquid and crystalline states. Comets, exposed dusty surfaces, planetary rings and zodiacal dust cloud are the examples of dusty plasma [10–12].
\nDust in atmosphere and in the entire universe is in different shapes and sizes. Mostly, it is in solid form and also presents in liquid and gaseous forms. If dust particle coexists with plasma, it forms dusty (complex) plasma. Dust particle acquires charge and is affected by electric and magnetic fields. Temperature on the dust particle is approximately 10 K, and electric potential varies from 1 to 10 V is mostly negatively potential. Charge on dust particle depends on the flow of electrons and ions. It can be grown or inserted in low-temperature plasma at low degree of ionization in the laboratory. It becomes a dominant component of dusty plasma for transports of energy, momentum and mass. In these days, dusty plasma becomes more significant in the field of research of science and technology by investigating its transport properties in the laboratory. Currently, complex plasma becomes more interesting field of research. The major ratio of plasma in the universe is dusty plasma. It is a huge occurrence in magneto and ionosphere of earth, atmosphere of stars, sun, solar wind, galaxies cosmic radiations, planetary rings comet tails and nebulae. Dusty plasma also known as complex plasma has electrons, ions, neutral and dust particles components [12].
\nDust particles in plasma gain the electric charge, which they obtained in the plasma. The charge on dust particle can range from zero to hundreds of thousands of electrons depending on the size and shape of the dust particle. When a dust grain immersed in an ionized medium, soon it gains a charge when its surface is contact with plasma. This is valid for small floating objects like dust particles, also for electrode surfaces and macroscopic objects inserted into the discharge tube. This charge determines by balancing positive ion and the electron current. These currents must be equal in a steady state. Due to high mobility of the electrons as compared to ions, the surface collects negative charges, which attracts positive ions and repel the electrons until an immobile state is reached. Therefore, by equating fluxes between electrons and ions, the charge on particle can be obtained. This charge is responsible for confinement and long lifetimes of particles in plasmas. Due to interactions between these particles, waves, instabilities and other collective phenomena are produced.
\nDust particles are much larger than electrons and ions, and its size varies from 10−3 m to 10−9 m. A typically used particle may have a diameter of 3.50±0.05 μm and a mass ~3×10−11 kg. Such particles are named mono disperse. It has any shape, mostly spherical, and also easily observed in laboratory without any microscope. It is made by conducting or dielectric material [12, 13].
\nDust particles that collect the plasma particles such as electrons and ions on their surface become an interacting particle. In the dusty plasma energy, momentum and mass are transferred through dust particle. Dust particle may be in liquid, solid and gaseous forms.
\nPlasma is widely used in the field of science, technology and in our daily life. Plasma science also affects human life in different fields and ways. It plays a very important role in the sterilizing of medical instruments, laser, developments of fusion energy, intense particle beams, plasma processing, lightening, development fusion energy controlling, high-power energy sources, high-power radiations sources and water purification plant [3]. X-ray and ultraviolet electron beams and radiations, which are emitted by plasma-centered sources, have a diversity of applications in different fields.
\nIn textile industries, plasma used for surface treatment shows a large number of advantages. Different plasma treatments were used to modify the surface of fabrics, such as cold plasma treatments, which modify the large and reliable systems in fabrics. Three effects are found on the textile surfaces during plasma treatments: (1) cleaning effect, (2) increase of micro roughness and (3) produce deliquescent surfaces. The plasma polymerization is a process in which solid polymeric materials are deposited on textile substrate with required properties; currently, this technique is under development, and in this technique only upper surface is modified. This treatment also has optimistic effects on printing and dying of wool and has proved to be successful in shrink-resist. Improvement of surface wetting technique in artificial polymers is done with treatment in oxygen-, air- and NH3 plasma. Hydrophilic treatment used as a dirt-repellent and antistatic finish [Sparavigna, 2008]. Plasma treatment is environmental friendly in which only upper layer of surface is modified without changing its bulk properties. Vacuum plasma is used on a small scale as is used in reel-to-reel machinery at the industrial scale; it plays a vital role to enhance a number of properties, including liquid repellency, the specific surface functionality and improved wet ability.
\nThe surfaces of optics and contact lenses can be cleaned by plasma treatment. In this process, thin layer of the organic impurity is removed almost from all surfaces. Plasmas are used for the manufacturing of semiconductor chips in discharge tube, and the dust particles are essentially formed from the reactive gases used for the creation of plasmas. These dust particles are used for the manufacturing of semiconductor chips and give the significant results for the conduction of electric current. In the aerospace industries, plasma treatment of composite and polymer materials are commonly used. This treatment has advantages in adhesive and cleaning bonding of the dissimilar materials. In the automotive industries, adhesion of the exterior and interior parts is increased by the plasma treatment apparatus and plasma treatment procedures without any heat effect that commonly facing with flames. The Henniker is well known as a great leader in this field because he controlled plasma systems with low cost for almost in every common automotive development mission [2, 3, 11].
\nIn the plasma, when an electron is displaced from their equilibrium position, the electrostatic forces due to ions pull the electron back. Due to small mass of electron, overshoot the ions and oscillation in plasma are started. The plasma oscillation leads to plasma frequency which is denoted by
where
The phase velocity is \n
In this chapter, we classified plasma waves with respect to direction of motion of charge particles (electron, ion), which are perpendicular or parallel to the direction of propagation. The longitudinal waves consist of electrostatic (ion and electron) waves and transverse wave consists of electromagnetic (ion and electron) waves, mostly transverse component and sometime longitudinal component also.
\nPlasma oscillation, also known as Irving Langmuir waves, is discovered by American scientists Irving Langmuir and Lewi Tonks in 1920, and the frequency of plasma oscillation is high due to low electron density in the conducting materials such as metal and plasma. It is found in interstellar gas clouds and earth atmosphere. Mathematically, it is written as \n
The upper hybrid oscillation is a resonance phenomenon in plasma which the electric field perpendicular to the magnetic field and waves propagates across the static magnetic field: \n
It is a type of longitudinal waves in magnetized plasma that propagates due to compression mode and its direction along the magnetic field lines. The particle velocity, sound pressure, sound intensity and particle displacement are the important quantities of acoustic waves. It exhibits the interference, diffraction and reflection phenomenon. In general, ion acoustic wave formula is [1, 14], \n
In this section, we introduce the molecular dynamic simulation technique and its theoretical background that was needed in this work. We introduced a system of mathematical model that used and applied in the computer simulations and also explained steps for molecular dynamics simulation codes. In addition, it also explains the simulation parameters and techniques. Yukawa potential was first time proposed by a scientist Hideki Yukawa in 1930. Through this potential, charged particles do interact, which is defined as
\nwhere
The particle current or momentum current for single atomic (molecule) species in MD unit is given as:
\nwhere
The correlation function of the current vector component is defined as:
\nFor the isotropic fluid under the consideration of symmetry, Eq. (6) can be expressed in terms of longitudinal current correlation and transverse current correlation in the relative direction of
By setting \n
\nEq. (7) split into longitudinal current and transverse current by using the Fourier transformation as:
\nInserting the value of
Longitudinal current correlation function explains the direction of propagates along Z-axis in the positive and negative directions of Z-axis with wave number. This equation also specifies about longitudinal motion of charge particle.
\nUsing the Fourier transformation for Eq. (7), the transverse current correlation is defined as:
\nwhere
\n\nEq. (12) states about the directions of propagation of electromagnetic waves with respect to wave number along the positive and negative X- and Y-axes. The transverse current correlations also describe us about transverse motion of charge particle in complex system or complex (dusty) plasma [15–17].
\nIn this section, we select a system of choice having number of particles
To illustrate the behaviour of correlation function of SCCD plasma using EMDS, the time-dependent normalized longitudinal current correlation (CL(
Variation of CL(
Variation of CL(
Variation of CL(
\n\nFigures 4\n–\n6\n demonstrate that the simulation results are obtained for CT(k,
Variation of CT(
Variation of CT(
Variation of CT(
The EMD simulation method is used to investigate the CL(
The authors thank Z. Donkó (Hungarian Academy of Sciences) for providing his thermal conductivity data of Yukawa Liquids for the comparisons of our simulation results and useful discussions. We are grateful to the National High Performance Computing Center of Xian Jiaotong University and National Advanced Computing Center of National Center of Physics (NCP), Pakistan, for allocating computer time to test and run our MD code.
\nNICDPs | non-ideal complex (dusty) plasmas |
EMD | equilibrium molecular dynamics |
Γ | Coulomb coupling |
\nκ\n | Debye screening length |
CT(k,t) | transverse current correlation function |
MD | molecular dynamics |
LTE | local thermodynamic equilibrium |
SCP | strongly coupled plasma |
PBCs | periodic boundary conditions |
CL(k,t) | longitudinal current correlation function |
Railway technical condition has a significant impact on the safety and traffic flow. One of the most important tasks of a railway responsible is to ensure regular maintenance that includes the diagnostics of the actual condition. The diagnostics prolongs the railway service life and contributes to preserve or improve the quality of geometrical and construction parameters of railway lines mainly dependent on materials used in its construction or reconstruction.
There are many ways to diagnose railway lines, starting from visual fault detection through video inspection and ending with the use of various automated diagnostics systems differed by their physical principles. The paper deals with diagnostics methods of railway track that the railway responsible required from civil engineers.
The diagnostics of the railway track done by civil engineers have to enable to determine the main railway parameters: operational safety, changes in the designed geometric directional and height parameters of the railway construction, the impact of quality degradation, material wear of constructional elements [1].
The diagnostics method are divided concerning the range of diagnostics needs and the possibilities of used methods. Generally, we distinguish diagnostics of absolute geometric position, diagnostics of relative geometric position, and diagnostics of constructional track parameters.
The geometric track position represents the projected directional and height parameters of railway lines. From the point of view of the assessment of traffic influences, we divide the geometric position into absolute and relative one. The absolute geometric track position refers to the projected one and relative track position refers to the mathematical functions of analytical geometry like curve, line, cubic parabola, etc. In practice, the absolute directional position of the track is given by the horizontal distance between the track axis and a railway benchmark, and the absolute height position of the track is given by the vertical distance between the top of the non-elevated rail and the benchmark. The relative directional position of the rails represents the positional differences of rails from the projected values. The relative height position of the rails contains a longitudinal change of height of both rails, the mutual height position of rails called rail cant, and the change of the mutual height position of the opposite heads called rail collapse [2, 3].
The track arrangement includes track gauge, gauge change as widening or shrinking, transverse inclination of the rails, size of connection gaps, parallelism of connections, division of sleepers, fastening of rail tracks.
Traffic effects appear as vertical and horizontal forces acting on the railway track with the character of static and dynamic loading. Long-term traffic effects cause changes in the geometric position and arrangement of the track, changes of the constructional elements, which will be reflected in track deformations, material wear, and material fatigue, and changes in the subsoil, which cause deformations and degradation of physical railway characteristics.
Climate conditions especially temperature, water, and snow influences cause changes in rail length. Low temperature causes the creating of cracks of wooden sleepers and changing the elasticity of some materials. High temperature worse quality properties of non-metallic materials as plastic and rubber elements. Waterfalls cause corrosion of metal parts of the construction, mold, and rot of wooden sleepers, and overall deterioration of subsoil. Long-term precipitation causes increasing the level of groundwater. Snowfall reduces traffic cross-section and makes it inoperable. The effects of traffic and climate changes on the railway line depend on:
traffic loading and speed,
type and intensity of railway traffic,
the quality of the material of the constructional elements of the railway line,
the quality of the railway construction,
condition of railway vehicles,
the scope and quality of maintenance and repairs.
Traffic harms the absolute and relative directional track position. Concerning the absolute directional position, the horizontal forces cause moving the rail in their direction, which caused the change of axial distances of multi-track lines or the change of the distance to objects located around the track. The absolute directional track position can be found out by using measuring devices or geodetic methods.
Concerning the relative directional position, the horizontal forces cause a change in the curvature expressed as ratio 1/r, which appears as changes in the size and direction of the acting forces. Directional deformations are determined by measuring the uplift above the curve chord. The difference between the projected and the actual measured value shall not exceed the value predetermined in national technical standards. The most common directional deformations include:
disorders in the subsoil,
improperly designed geometric position of the track,
climatic conditions,
influence of railway vehicles,
insufficient maintenance or repairs.
Defects in directional position are expressed in discomposed driving, deterioration of comfort, increasing the stress of constructional elements, greater wear of the material, and finally the deterioration of quality traffic route. Corrections of errors in the directional track position are performed mechanically by automatic or mechanical tamper [4, 5].
The vertical forces acting on the railway cause elastic or flexible permanent deformation of the height position of railway tracks, which is reflected in the reduction of level one or both of the tops of the rails. The height deformations can appear as continual or short changes of a track. The continual changes of track height are generally evaluated as absolute errors of height position, with uneven drops of the rails causing a change of cross-section and the change of the mutual relative position of the track and the traction line. The absolute height position of the track is measured either manually (by a simple measuring device) or by geodetic height measurements. Changes in relative height may affect all or some of the monitored parameters of geometric position (track depression, elevation, or collapse). The longitudinal height changes of the rails arise in places of increased vertical forces (joints) or failures in the subsoil sediments. The deformations can be single-sided on a rail or double-sided-symmetrical on both rails in the same place and double-sided-cross on both rails with a shifted start. Cracks and drops of joints affect driving comfort and cause an increase of vertical forces (shocks). The longitudinal height of the rails is determined by geodetic methods or by measuring wagons. The mutual height changes of both rails negatively affect the loading on the rails. Demolition is the most monitored parameter in terms of operational safety.
Track collapse is calculated from the height difference measured at the length of the respective base and calculate as the slope (in form 1: n). The not permitted inclination is assessed as an error only if the length of the slope is minimal 2.0 m. The most common causes of changes in the height position of the rails are the following:
uneven compaction of the trackbed,
disorders in the subsoil,
changes in the properties of the subsoil,
loose fasteners,
contact gaps,
uneven distribution of sleepers,
incorrect cant
acting the railway vehicles (unevenness loading),
poor maintenance and repairs
Troubleshooting at the height of the rails is done manually by small range devices or mechanically by automatic machine jacks. The negative effect of the traffic on the track arrangement appears as an extension or reduction of the track gauge. These changes affect the movement of railway vehicles on the running track, which causes changes in the loading of constructional elements. Track gauge is controlled in discrete points using gauges, or continuously by measuring devices. Besides the value of the track gauge also the course of the change of the gauge between two different values at a distance of 1,0 m is assessed. The reasons for the widening of the gauge include poor installation of the rail grate, lateral wear of the rails, wear and loosening of fasteners, uneven pushing of the bases, construction of railway vehicles, bending of sleepers, and insufficient maintenance and repairs. The reduction in gauge causes rolling of railheads, deformation of sleepers, uneven wandering of the rails. Repair of the incorrect gauge is performed according to the type of fastening and sleepers by flipping the clamps, folding the clamps, or by turning flat rib bases.
The main aim of diagnostics of the relative track geometric position is to find negative influences of force and dynamic effects of railway vehicles. Two types of relative diagnostics are used: partial diagnostics. Partial diagnostics is detecting changes in one or more parameters from the geometric arrangement rails. Complex diagnostics allows simultaneous measurement of all crucial parameters by one device on which the measuring means are located. According to the used measuring equipment and technologies, we divide diagnostics into analog devices based on manual manipulation, which detects permanent changes, and electronic devices, which allow registering the elastic deformations that occurred under traffic loading.
Partial diagnostics of the track was the most used method in the past for control the geometric position of the rail. Nowadays, it is often applied as a complementary method to visual diagnostics because of its unquestionable advantages such as speed of use in operational conditions, simple manual manipulation, and immediate output of results. Partial diagnostics is used to measure track gauge, relative mutual directional, and height position of rails. The most suitable equipment for these purposes seems to be a gauge measuring device, which measures permanent deformations of the track without any influences of the other parameters. Depending on the technology, the gauge measuring device can be used for discrete data recording or continual measurement with graphical and numerical output [6, 7].
The constructional principle of the analog gauge measuring device used for discrete diagnostics is based on direct or indirect measurement of a specific parameter while other track parameters are possible to estimate by using numerical calculations. The continual measurement of track geometrical parameters has a wider base of measuring devices based on the electronic principle of data recording. These devices usually measure the track gauge and the relative height position at the same time. In addition to the measured parameters, the constructional track parameters are evaluated in post-processing.
Complex diagnostics of relative geometric track parameters control the mutual position of the left and right rail, track gauge, relative gauge changes, the longitudinal relative height position of both rails, rail cant, and track collapse evaluated above the relevant base. In addition to these static values, also dynamic influences and other parameters belong to microgeometry and material diagnostics of rails are evaluated. Devices for complex diagnostics work continually, although the measurement is performed pointwise with measurement steps of 250 mm, measured values are included in the outputs of the evaluation of individual parameters and the condition of the line. Physical principles of complex diagnostics devices enable contact or contactless measurement, the result of which is in the form of graphical record, numerical record, local evaluation, sectional and overall evaluation of railway conditions, which output is in the digital or video form. Besides, the proposal of maintenance measures is a part of the output of complex diagnostics. The most complex diagnostics of the railway line is realized by Measuring wagon and is involved in regular maintenance programs, which prepare belong to the competence of railways management [5].
Diagnostics of constructional elements of railway belong to the necessary part of the process of railway diagnostics. Great attention is paid to rail condition, its time changes, and deformation, while the other rail parameters are diagnosed only visually, due to their less impact on the safety and fluentness of traffic. More detailed diagnostics is applied only in case of abnormal occurrence of destructive phenomena [8, 9]. Diagnostics of constructional elements of the track is divided into:
geometrical diagnostics of rail profiles,
material diagnostics of rail profiles,
diagnostics of microgeometry of rail profiles,
diagnostics of sleepers, small rails, and fasteners.
The size of wear of railhead (Figure 1) caused by railway traffic, horizontal deformation at the rail leading edge, and vertical deformation at the head of a rail are determined during geometrical diagnostics of rail profiles. The wear of the railhead is caused by wheel friction as the railway vehicle moves along the rail. The geometric shape of the railhead is gradually changed by the influence of traffic loading.
The manual device for measuring the rail wear on-site (source [
Material diagnostics of rail profiles aim to detect inner faults that occurred during railway traffic. Material defects can appear at the surface of the rail part, close below the surface, and inside the rail. Material diagnostics prefers non-destructive methods without any restriction in railway traffic as visual, capillary, or ultrasonic detections. The ultrasonic method is the regular diagnostics method and is performed by manual devices, measuring vehicles, or wagon detectors.
The diagnostics of sleepers focuses on concrete sleepers to search for cracks, which worsen its qualitative properties, damages of the surface of the basement, developed by incorrect repair technology and faults of holes need for sleeper screws. The visual inspection of sleepers focuses on the cracks laying on the surface of the basement, mechanical damage of the surface of the basement caused by railway traffic at the points of contact with other constructional elements, deformations of the shape of sleepers, rot, and mold, etc. Steel sleepers are controlled from the point of view of developing the cracks, shape deformations, changes of the shape and size of holes, and material corrosion.
The diagnostics of the absolute geometric position of the track is practically based on the control of the change of the track spatial position concerning the designed parameters included in the project documentation. The absolute track diagnostics is usually realized by geodetic methods that enable the determination of the spatial position of the track axis concerning the railway benchmarks defined in global European or national coordinate and height systems. Depending on the used geodetic method, the control of the spatial track position can reveal either directly a spatial change or only a change in directional or height position of the track. Generally, the spatial change of a point is defined by the spatial vector defined by three main components: size, direction, and time. Defined by the three main components, which are the magnitude of the direction and the time of action [11, 12, 13]. The detection of these parameters can capture geodetic methods, based on the contact and contactless principle, such as terrestrial laser scanning, digital photogrammetry, spatial polar method, kinematic GNSS method, etc. Altitude changes are monitored by the method of precise leveling, and the polar method provided by robotic total stations is currently suitable for detecting displacements of the railway structure in 2D space. The use of the geodetic method for monitoring a railway line depends on the accessibility of the track, length of the railway closure, accuracy requirements, the expected size of the spatial change, which depends on the construction of the railway superstructure, etc.
Ballastless railway line (BRL) is a modern railway construction that ensures safety and traffic comfort while increasing demands for traffic speeds above 160 km/h, which is accompanied by an increase in traffic loading. The BRL refers to the construction of a railway superstructure in which the spreading function of the trackbed is replaced by reinforced materials and which is placed on a concrete or asphalt base plate. The ballastless construction has proven to be a practical and advantageous construction system of the railway superstructure in many countries. An essential reason to build such a railway superstructure is the high track stability associated with fluent vehicles movement and traffic comfort, especially for passengers. The railway responsible appreciates significantly lower requirements for track maintenance, which is accompanied by smaller financial demands. This high driving comfort can only be obtained, in the case of the classic superstructure design, in conjunction with very high operating costs. According to [1] the ballastless railway construction can reduce the following cost items:
demands on revision and inspection of geometric track position,
climate influence on railway superstructure and subsoil,
vegetation care,
demands on track reconstruction,
minimization of cleaning track bed,
increasing time interval of track renewal.
In Slovakia, the ballastless railway construction is built on modernized railway sections especially in tunnels, which have the required subsoil properties, with minimal settlement and bridges without subsidence. In summary, the construction of BRL is suitable due to the reduction of the excavation area, durability and stability of the track position, and minimal demands on maintenance.
The diagnostics of geometrical track position was realized railway section with ballastless construction RHEDA 2000®. The total length of the ballastless construction is 4480 m and passes through various types of track subsoil as tunnel (Figure 2), open-air (Figure 3), and bridges (Figure 4). Due to the difference in subsoil stiffness in the particular line sections, the system of the ballastless railway line was modified to reflect the thickness and reinforcement of the concrete structure.
Ballastles railway line in a tunnel.
Ballastles railway line on bridges.
Ballastles railway line in open-air.
The critical part of ballastless construction is the transition section laying between ballastless and standard railway construction because of the change of construction stiffness. During the diagnostics process, great attention was paid to this part of railway construction to determine deformations.
Partial diagnostics of geometrical track position was performed by manual gauge devices ROBEL and GEISMAR to find out gauge changes and track elevation at each mounting node. Complex diagnostics of the structural and geometrical track position was realized by the electronic measuring system KRAB™-Light. The track geometric parameters are measured by contact sensors and recorded in each 250 mm step. The result of diagnostics is obtained in postprocessing:
track gauge is measured by a potentiometric sensor on the left separate wheel (Figure 5),
the directional position is given by horizontal uplift of the right rail,
height position is given by vertical uplift of the right rail,
track elevation measured by inclinometer (Figure 6),
quasi-collapse on a short base,
the longitudinal inclination of the track obtained only by special inclinometer configuration,
distance traveled obtain by an incremental rotary sensor.
Changes in track gauge defined in mm.
Track elevation defined in mm.
The project of diagnostics of ballastless railway line suggested using geodetic methods to define the spatial, height, and positional track changes.
The positional observations of BRL were realized by a video-assisted robotic total station utilizing Trimble VISION technology, which means that it sees everything without a trip back to the instrument and selects targets with just a tap of the controller screen. So, measurements are drawn to the video image and the surveyor can be certain to never miss a shot he needs. The total station involves also FineLock technology to detect targets without interference from the surrounding prism and SurePoint accuracy assurance to correct instrument pointing. The primary precision of the total station is defined by angle accuracy of 0.3 miligons, distance accuracy in standard prism mode is 1 mm + 2 ppm and in tracking mode, it is 4 mm + 2 ppm. So, the technology is destined to be used for both discrete and continuous measurements of the ballastless railway.
Geodetic observations of ballast-less track were realized in standard prism mode to find out spatial track change of ballastless construction in particular points and in tracking mode to evaluate spatial changes from continual observations. The measurements were realized in observational epochs with a period of half a year and spatial changes were evaluated from the differences of the actual and first epoch of spatial vectors.
The organization of the observational epoch consisted of a particular measurement of both rails under traffic closure. The particular points were signalized on each eighth sleeper (5 m) by the marks drawn on the concrete sleeper. Diagnostics of geometrical track position assumes also to determine the longitudinal and transversal changes of the track axes, which are monitored in particular measurement epochs. For this reason, the geodetic observations were pointed to the right rail of the railway line the axes position was defined in post-processing by offset regime. For the purpose to eliminate a pointing error, coordinates of the particular points were converted into a projected system by using track-projected parameters. The analysis of track positional changes belongs to the statistical hypothesis testing based on the postulate of null hypothesis [14]:
where
and the measured displacement in the i-th and first epoch of measurement
Suppose, the measured values are normally distributed
where
In practice, the real value of displacement is unknown and hypothesis testing of the positional displacement can be established by the following inequalities:
If
If
If
The height measurements were performed by precise leveling method with the level instrument, of which the unit standard deviation does not exceed value 0.40 mm in every observational epoch. The height differences were related to the reference network, which consists of permanently stabilized leveling marks, stabilized either on the base of the masts or in the concrete curb. The critical value for determining the height stability of the reference network was determined from the measured height change test and is determined as twice the mean value of the standard deviations found in the particular observation epochs. The process of control the stability of the height reference network consists of estimating the parameters of the regression line, constructed from the difference between the elevation in the first epoch and the i-th epoch, testing of outliers, and estimating the a posteriori accuracy of the network [15].
The analysis of height changes consists of assessing the elevation differences of the i-th and the first leveling. If the standard deviation of the leveling network of the length L in the i-th measurement is given by the relation:
the accuracy of the heights differences is defined by the standard deviation:
out of which we define the probability
However, the critical limits which represents the reliability interval for the proof of the height changes of the particular points were defined according to the relation:
Terrestrial laser scanning has become a very useful method for acquiring an accurate three-dimensional detail of a complex observed object or facility, but its application in engineering surveying has some limitations resulting from the uniqueness of a measured structure. Railway track belongs to the long line ground objects and so the technology of its laser scanning has to be conformed to this fact.
For the scanning procedure of rail track, we used pulsed dual-axis compensated laser scanner Leica ScanStation C10 with the prescribed accuracy of a single measurement in position ±6 mm and distance ±4 mm and angular accuracy is ±12″. These specifications designate standard deviation for target acquisition ±2 mm. The scanning system is based on a 3R green laser of wavelength 532 nm with a scanning range of 300 m [16].
ScanStation was situated on both sides of railway lines and its 3D position was determined by resection method related to the railway benchmarks. The scan resolution was 3 cm at a range of 30 m while keeping the prescribed accuracy in position ±6 mm. The scan area was limited by the horizontal field of view from 0° to 180° and vertical field of view from −45° to +90°.
The point cloud processing belongs to the most time-consuming and very important part of data utilization. Each point in the point cloud is measured concerning the scanner position, and so the parameter transformation from local to the global national system is necessary to fit the point cloud to coordinate system. For this fact, the connection between laser scanning and terrestrial measurement is necessary, which is based on the 3D position of identical points of both systems. The combination both of measurement methods also helps to verify the positional data, which are utilized in the post-processing procedures. The positional control of the observed point cloud is also realized by the photogrammetric method, which enables the overlapping digital photos, made by a video camera, with corresponding scans.
The point cloud processing continues with the feature codes extraction directly from the point cloud and their export to feature code processing software. While scanning a site, the scanner captures everything in the selected field of view. Objects, which are not relevant to the surveyor have to be removed from the scan. This removal process is an interactive process and a skilled operator needs only a few minutes for extracting and deleting the useless objects. The process of determination of track changes consists mostly of applying mathematical procedures especially regression analysis and mathematical modeling to receive the faithful model of reality [17, 18]. The received mathematical model was finally used to reconstruct the railway track geometry and to evaluate the transversal and longitudinal profiles of a track section (Figure 7).
Illustration of transversal profiles of both railway lines obtained by numerical analysis of clouds of data.
Evaluation of partial and complex track diagnostics consists of determining “Local errors” specified in railway sections, which differ by the subsoil construction. The Local errors are defined by values of deviation of the measured parameter from design one. Complex track diagnostics is evaluated by “Quality number”, which is determined as the ratio between both observed standard deviation and theoretical one. Based on the value of the quality number, the level of maintenance of the railway line is recommended or repair work is specified.
The standard deviation of determining track changes measured by geodetic methods gives the view on a-posteriori accuracy of the observed track parameter. It involves the error of multitrack target position regarding track axis (±2 mm) and precision of displacement estimation process (±2–3 mm). The longitudinal displacement of the ballastless track was not evaluated, because the precision of multitrack target positioning in the longitudinal direction of the track is out of the assumed value of longitudinal displacement. Concerning the discrete observations, the main problem seems to be in permanent signalization of the particular points on the ballast-less track construction to minimize the error of reflector target positioning.
Precision analysis of digital leveling realized on ballast-less track consists in both analyses of vertical reference network and precision analysis of the track measurements. The first one brought the view on the stability of reference system and the standard deviation, as the main characteristic of used leveling method. Precision analysis of track measurements consists of defining the standard deviation of height differences and the confidential interval, which qualifies the evident vertical displacements of track construction. The precision analysis of geodetic observations realized on ballast-less track construction was performed in conformity with the appropriate technical standards. Accuracy of used digital leveling satisfies the demands, which are defined for observation of such an unconventional track construction.
The application of laser scanning brings to surveyors a great possibility to display the real world in much more detail than it was in past, and it brings also new approaches to utilize the scanning outputs by a using variety of software. For civil engineering, the most common output from laser scanning is the digital terrain model, which can be applied in map-making, designing, deformations diagnostics, construction inspection, or historical objects reconstruction.
This article is the result of the implementation of the project VEGA 1/0643/21 “Analysis of spatial deformations of a railway track observed by terrestrial laser scanning”, supported by the Scientific Grant Agency of the Ministry of Education, Science, Research and Sport of the Slovak Republic and Slovak Academy of Sciences.
This article is the result of the implementation of the project KEGA 038ŽU-4/2020 “New approaches to teaching physical geodesy in higher education”, supported by the Scientific Grant Agency of the Ministry of Education, Science, Research and Sport of the Slovak Republic.
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From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. 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It affects women in a higher proportion than men (3:1 cases). Several reports suggest a link between female sexual hormones (estrogens) and RA features. It’s been described that biological processes where basal estrogen levels are altered like in menstruation, pregnancy, and menopause modifies RA onset, flare, disease severity, and inflammation. Estrogens have a direct action upon the immune system though ERα and ERβ receptors, which have distinct affinity to estrogen concentrations and modifications and have effects upon RA in a dose and receptor dependent manner. The studies focused on dose dependent response at experimental settings reveal a wide (from 25 pg/L to several μg/L) and even contradictory spectrum of effects in patients and cells. 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The venous system is the most frequently attacked vessel system. The arterial system, when involved, increases the severity and morbidity of Behçet’s disease. Cardiac involvement, although rare, can be very subtle and in itself increases the mortality. Vasculitis is the hallmark pathology resulting in occlusion, aneurysms, or both. Vascular involvement may be very challenging in all phases of treatment beginning from diagnosis till recovery and remission.",book:{id:"5898",slug:"behcet-s-disease",title:"Behcet's Disease",fullTitle:"Behcet's Disease"},signatures:"Orhan Saim Demirtürk, Hüseyin Ali Tünel and Utku Alemdaroğlu",authors:[{id:"199021",title:"Associate Prof.",name:"Orhan Saim",middleName:null,surname:"Demirtürk",slug:"orhan-saim-demirturk",fullName:"Orhan Saim Demirtürk"}]}],mostDownloadedChaptersLast30Days:[{id:"42989",title:"Treatment of ANCA-Negative Small Vessel Vasculitis",slug:"treatment-of-anca-negative-small-vessel-vasculitis",totalDownloads:2848,totalCrossrefCites:0,totalDimensionsCites:0,abstract:null,book:{id:"3319",slug:"updates-in-the-diagnosis-and-treatment-of-vasculitis",title:"Updates in the Diagnosis and Treatment of Vasculitis",fullTitle:"Updates in the Diagnosis and Treatment of Vasculitis"},signatures:"Christina G. Katsiari, Theodora Simopoulou and Lazaros I. 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In this chapter, we will introduce the current and progress of self-management in patients with rheumatoid arthritis.",book:{id:"8860",slug:"rheumatoid-arthritis-other-perspectives-towards-a-better-practice",title:"Rheumatoid Arthritis",fullTitle:"Rheumatoid Arthritis - Other Perspectives towards a Better Practice"},signatures:"Wen Luo, Xiuli Zhang and Kaijing Ren",authors:[{id:"313197",title:"B.A.",name:"Wen",middleName:null,surname:"Luo",slug:"wen-luo",fullName:"Wen Luo"},{id:"315667",title:"Dr.",name:"XiuLi",middleName:null,surname:"Zhang",slug:"xiuli-zhang",fullName:"XiuLi Zhang"},{id:"315668",title:"Prof.",name:"Kaijing",middleName:null,surname:"Ren",slug:"kaijing-ren",fullName:"Kaijing Ren"}]},{id:"72458",title:"Introductory Chapter: Rheumatoid Arthritis - Overview of Current Facts and Strategies",slug:"introductory-chapter-rheumatoid-arthritis-overview-of-current-facts-and-strategies",totalDownloads:706,totalCrossrefCites:1,totalDimensionsCites:1,abstract:null,book:{id:"8860",slug:"rheumatoid-arthritis-other-perspectives-towards-a-better-practice",title:"Rheumatoid Arthritis",fullTitle:"Rheumatoid Arthritis - Other Perspectives towards a Better Practice"},signatures:"Reem H.A. 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The usual course of the disease is characterized by recurrent inflammatory periods. Recurrent inflammatory attacks may result in irreversible damage and significant visual loss. Early and effective treatment is required to prevent ocular morbidity. Recent developments in the treatment of ocular Behçet’s disease like biological agents are promising with a rapid effect and high remission rates.",book:{id:"5898",slug:"behcet-s-disease",title:"Behcet's Disease",fullTitle:"Behcet's Disease"},signatures:"Esra Sahli and Ozlem Gurbuz-Koz",authors:[{id:"204946",title:"Dr.",name:"Esra",middleName:null,surname:"Sahli",slug:"esra-sahli",fullName:"Esra Sahli"},{id:"207468",title:"Dr.",name:"Ozlem",middleName:null,surname:"Gurbuz-Koz",slug:"ozlem-gurbuz-koz",fullName:"Ozlem Gurbuz-Koz"},{id:"207469",title:"Dr.",name:"Yildiz",middleName:null,surname:"Ozdemir",slug:"yildiz-ozdemir",fullName:"Yildiz Ozdemir"}]},{id:"42990",title:"Infectious Causes of Vasculitis",slug:"infectious-causes-of-vasculitis",totalDownloads:4731,totalCrossrefCites:3,totalDimensionsCites:6,abstract:null,book:{id:"3319",slug:"updates-in-the-diagnosis-and-treatment-of-vasculitis",title:"Updates in the Diagnosis and Treatment of Vasculitis",fullTitle:"Updates in the Diagnosis and Treatment of Vasculitis"},signatures:"Jacques Choucair",authors:[{id:"162999",title:"M.D.",name:"Jacques",middleName:"Elias",surname:"Choucair",slug:"jacques-choucair",fullName:"Jacques Choucair"}]}],onlineFirstChaptersFilter:{topicId:"1042",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:139,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:123,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:21,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:11,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. 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My method of translating this into day to day in clinical practice is non-exhaustible and my habit of exchanging knowledge and expertise with others in those fields is the code and secret of success.",institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"313277",title:"Dr.",name:"Bartłomiej",middleName:null,surname:"Płaczek",slug:"bartlomiej-placzek",fullName:"Bartłomiej Płaczek",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/313277/images/system/313277.jpg",biography:"Bartłomiej Płaczek, MSc (2002), Ph.D. (2005), Habilitation (2016), is a professor at the University of Silesia, Institute of Computer Science, Poland, and an expert from the National Centre for Research and Development. His research interests include sensor networks, smart sensors, intelligent systems, and image processing with applications in healthcare and medicine. He is the author or co-author of more than seventy papers in peer-reviewed journals and conferences as well as the co-author of several books. He serves as a reviewer for many scientific journals, international conferences, and research foundations. Since 2010, Dr. Placzek has been a reviewer of grants and projects (including EU projects) in the field of information technologies.",institutionString:"University of Silesia",institution:{name:"University of Silesia",country:{name:"Poland"}}},{id:"35000",title:"Prof.",name:"Ulrich H.P",middleName:"H.P.",surname:"Fischer",slug:"ulrich-h.p-fischer",fullName:"Ulrich H.P Fischer",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/35000/images/3052_n.jpg",biography:"Academic and Professional Background\nUlrich H. P. has Diploma and PhD degrees in Physics from the Free University Berlin, Germany. He has been working on research positions in the Heinrich-Hertz-Institute in Germany. Several international research projects has been performed with European partners from France, Netherlands, Norway and the UK. He is currently Professor of Communications Systems at the Harz University of Applied Sciences, Germany.\n\nPublications and Publishing\nHe has edited one book, a special interest book about ‘Optoelectronic Packaging’ (VDE, Berlin, Germany), and has published over 100 papers and is owner of several international patents for WDM over POF key elements.\n\nKey Research and Consulting Interests\nUlrich’s research activity has always been related to Spectroscopy and Optical Communications Technology. Specific current interests include the validation of complex instruments, and the application of VR technology to the development and testing of measurement systems. He has been reviewer for several publications of the Optical Society of America\\'s including Photonics Technology Letters and Applied Optics.\n\nPersonal Interests\nThese include motor cycling in a very relaxed manner and performing martial arts.",institutionString:null,institution:{name:"Charité",country:{name:"Germany"}}},{id:"341622",title:"Ph.D.",name:"Eduardo",middleName:null,surname:"Rojas Alvarez",slug:"eduardo-rojas-alvarez",fullName:"Eduardo Rojas Alvarez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/341622/images/15892_n.jpg",biography:null,institutionString:null,institution:{name:"University of Cuenca",country:{name:"Ecuador"}}},{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/215610/images/system/215610.jpeg",biography:"Muhammad Sarfraz is a professor in the Department of Information Science, Kuwait University. His research interests include computer graphics, computer vision, image processing, machine learning, pattern recognition, soft computing, data science, intelligent systems, information technology, and information systems. Prof. Sarfraz has been a keynote/invited speaker on various platforms around the globe. He has advised various students for their MSc and Ph.D. theses. He has published more than 400 publications as books, journal articles, and conference papers. He is a member of various professional societies and a chair and member of the International Advisory Committees and Organizing Committees of various international conferences. Prof. Sarfraz is also an editor-in-chief and editor of various international journals.",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"32650",title:"Prof.",name:"Lukas",middleName:"Willem",surname:"Snyman",slug:"lukas-snyman",fullName:"Lukas Snyman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/32650/images/4136_n.jpg",biography:"Lukas Willem Snyman received his basic education at primary and high schools in South Africa, Eastern Cape. He enrolled at today's Nelson Metropolitan University and graduated from this university with a BSc in Physics and Mathematics, B.Sc Honors in Physics, MSc in Semiconductor Physics, and a Ph.D. in Semiconductor Physics in 1987. After his studies, he chose an academic career and devoted his energy to the teaching of physics to first, second, and third-year students. After positions as a lecturer at the University of Port Elizabeth, he accepted a position as Associate Professor at the University of Pretoria, South Africa.\r\n\r\nIn 1992, he motivates the concept of 'television and computer-based education” as means to reach large student numbers with only the best of teaching expertise and publishes an article on the concept in the SA Journal of Higher Education of 1993 (and later in 2003). The University of Pretoria subsequently approved a series of test projects on the concept with outreach to Mamelodi and Eerste Rust in 1993. In 1994, the University established a 'Unit for Telematic Education ' as a support section for multiple faculties at the University of Pretoria. In subsequent years, the concept of 'telematic education” subsequently becomes well established in academic circles in South Africa, grew in popularity, and is adopted by many universities and colleges throughout South Africa as a medium of enhancing education and training, as a method to reaching out to far out communities, and as a means to enhance study from the home environment.\r\n\r\nProfessor Snyman in subsequent years pursued research in semiconductor physics, semiconductor devices, microelectronics, and optoelectronics.\r\n\r\nIn 2000 he joined the TUT as a full professor. Here served for a period as head of the Department of Electronic Engineering. Here he makes contributions to solar energy development, microwave and optoelectronic device development, silicon photonics, as well as contributions to new mobile telecommunication systems and network planning in SA.\r\n\r\nCurrently, he teaches electronics and telecommunications at the TUT to audiences ranging from first-year students to Ph.D. level.\r\n\r\nFor his research in the field of 'Silicon Photonics” since 1990, he has published (as author and co-author) about thirty internationally reviewed articles in scientific journals, contributed to more than forty international conferences, about 25 South African provisional patents (as inventor and co-inventor), 8 PCT international patent applications until now. Of these, two USA patents applications, two European Patents, two Korean patents, and ten SA patents have been granted. A further 4 USA patents, 5 European patents, 3 Korean patents, 3 Chinese patents, and 3 Japanese patents are currently under consideration.\r\n\r\nRecently he has also published an extensive scholarly chapter in an internet open access book on 'Integrating Microphotonic Systems and MOEMS into standard Silicon CMOS Integrated circuitry”.\r\n\r\nFurthermore, Professor Snyman recently steered a new initiative at the TUT by introducing a 'Laboratory for Innovative Electronic Systems ' at the Department of Electrical Engineering. The model of this laboratory or center is to primarily combine outputs as achieved by high-level research with lower-level system development and entrepreneurship in a technical university environment. Students are allocated to projects at different levels with PhDs and Master students allocated to the generation of new knowledge and new technologies, while students at the diploma and Baccalaureus level are allocated to electronic systems development with a direct and a near application for application in industry or the commercial and public sectors in South Africa.\r\n\r\nProfessor Snyman received the WIRSAM Award of 1983 and the WIRSAM Award in 1985 in South Africa for best research papers by a young scientist at two international conferences on electron microscopy in South Africa. He subsequently received the SA Microelectronics Award for the best dissertation emanating from studies executed at a South African university in the field of Physics and Microelectronics in South Africa in 1987. In October of 2011, Professor Snyman received the prestigious Institutional Award for 'Innovator of the Year” for 2010 at the Tshwane University of Technology, South Africa. This award was based on the number of patents recognized and granted by local and international institutions as well as for his contributions concerning innovation at the TUT.",institutionString:null,institution:{name:"University of South Africa",country:{name:"South Africa"}}},{id:"317279",title:"Mr.",name:"Ali",middleName:"Usama",surname:"Syed",slug:"ali-syed",fullName:"Ali Syed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/317279/images/16024_n.png",biography:"A creative, talented, and innovative young professional who is dedicated, well organized, and capable research fellow with two years of experience in graduate-level research, published in engineering journals and book, with related expertise in Bio-robotics, equally passionate about the aesthetics of the mechanical and electronic system, obtained expertise in the use of MS Office, MATLAB, SolidWorks, LabVIEW, Proteus, Fusion 360, having a grasp on python, C++ and assembly language, possess proven ability in acquiring research grants, previous appointments with social and educational societies with experience in administration, current affiliations with IEEE and Web of Science, a confident presenter at conferences and teacher in classrooms, able to explain complex information to audiences of all levels.",institutionString:null,institution:{name:"Air University",country:{name:"Pakistan"}}},{id:"75526",title:"Ph.D.",name:"Zihni Onur",middleName:null,surname:"Uygun",slug:"zihni-onur-uygun",fullName:"Zihni Onur Uygun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/75526/images/12_n.jpg",biography:"My undergraduate education and my Master of Science educations at Ege University and at Çanakkale Onsekiz Mart University have given me a firm foundation in Biochemistry, Analytical Chemistry, Biosensors, Bioelectronics, Physical Chemistry and Medicine. After obtaining my degree as a MSc in analytical chemistry, I started working as a research assistant in Ege University Medical Faculty in 2014. In parallel, I enrolled to the MSc program at the Department of Medical Biochemistry at Ege University to gain deeper knowledge on medical and biochemical sciences as well as clinical chemistry in 2014. In my PhD I deeply researched on biosensors and bioelectronics and finished in 2020. Now I have eleven SCI-Expanded Index published papers, 6 international book chapters, referee assignments for different SCIE journals, one international patent pending, several international awards, projects and bursaries. In parallel to my research assistant position at Ege University Medical Faculty, Department of Medical Biochemistry, in April 2016, I also founded a Start-Up Company (Denosens Biotechnology LTD) by the support of The Scientific and Technological Research Council of Turkey. Currently, I am also working as a CEO in Denosens Biotechnology. The main purposes of the company, which carries out R&D as a research center, are to develop new generation biosensors and sensors for both point-of-care diagnostics; such as glucose, lactate, cholesterol and cancer biomarker detections. My specific experimental and instrumental skills are Biochemistry, Biosensor, Analytical Chemistry, Electrochemistry, Mobile phone based point-of-care diagnostic device, POCTs and Patient interface designs, HPLC, Tandem Mass Spectrometry, Spectrophotometry, ELISA.",institutionString:null,institution:{name:"Ege University",country:{name:"Turkey"}}},{id:"267434",title:"Dr.",name:"Rohit",middleName:null,surname:"Raja",slug:"rohit-raja",fullName:"Rohit Raja",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/267434/images/system/267434.jpg",biography:"Dr. Rohit Raja received Ph.D. in Computer Science and Engineering from Dr. CVRAMAN University in 2016. His main research interest includes Face recognition and Identification, Digital Image Processing, Signal Processing, and Networking. Presently he is working as Associate Professor in IT Department, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur (CG), India. He has authored several Journal and Conference Papers. He has good Academics & Research experience in various areas of CSE and IT. He has filed and successfully published 27 Patents. He has received many time invitations to be a Guest at IEEE Conferences. He has published 100 research papers in various International/National Journals (including IEEE, Springer, etc.) and Proceedings of the reputed International/ National Conferences (including Springer and IEEE). He has been nominated to the board of editors/reviewers of many peer-reviewed and refereed Journals (including IEEE, Springer).",institutionString:"Guru Ghasidas Vishwavidyalaya",institution:{name:"Guru Ghasidas Vishwavidyalaya",country:{name:"India"}}},{id:"246502",title:"Dr.",name:"Jaya T.",middleName:"T",surname:"Varkey",slug:"jaya-t.-varkey",fullName:"Jaya T. Varkey",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246502/images/11160_n.jpg",biography:"Jaya T. Varkey, PhD, graduated with a degree in Chemistry from Cochin University of Science and Technology, Kerala, India. She obtained a PhD in Chemistry from the School of Chemical Sciences, Mahatma Gandhi University, Kerala, India, and completed a post-doctoral fellowship at the University of Minnesota, USA. She is a research guide at Mahatma Gandhi University and Associate Professor in Chemistry, St. Teresa’s College, Kochi, Kerala, India.\nDr. Varkey received a National Young Scientist award from the Indian Science Congress (1995), a UGC Research award (2016–2018), an Indian National Science Academy (INSA) Visiting Scientist award (2018–2019), and a Best Innovative Faculty award from the All India Association for Christian Higher Education (AIACHE) (2019). She Hashas received the Sr. Mary Cecil prize for best research paper three times. She was also awarded a start-up to develop a tea bag water filter. \nDr. Varkey has published two international books and twenty-seven international journal publications. She is an editorial board member for five international journals.",institutionString:"St. Teresa’s College",institution:null},{id:"250668",title:"Dr.",name:"Ali",middleName:null,surname:"Nabipour Chakoli",slug:"ali-nabipour-chakoli",fullName:"Ali Nabipour Chakoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/250668/images/system/250668.jpg",biography:"Academic Qualification:\r\n•\tPhD in Materials Physics and Chemistry, From: Sep. 2006, to: Sep. 2010, School of Materials Science and Engineering, Harbin Institute of Technology, Thesis: Structure and Shape Memory Effect of Functionalized MWCNTs/poly (L-lactide-co-ε-caprolactone) Nanocomposites. Supervisor: Prof. Wei Cai,\r\n•\tM.Sc in Applied Physics, From: 1996, to: 1998, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Determination of Boron in Micro alloy Steels with solid state nuclear track detectors by neutron induced auto radiography, Supervisors: Dr. M. Hosseini Ashrafi and Dr. A. Hosseini.\r\n•\tB.Sc. in Applied Physics, From: 1991, to: 1996, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Design of shielding for Am-Be neutron sources for In Vivo neutron activation analysis, Supervisor: Dr. M. Hosseini Ashrafi.\r\n\r\nResearch Experiences:\r\n1.\tNanomaterials, Carbon Nanotubes, Graphene: Synthesis, Functionalization and Characterization,\r\n2.\tMWCNTs/Polymer Composites: Fabrication and Characterization, \r\n3.\tShape Memory Polymers, Biodegradable Polymers, ORC, Collagen,\r\n4.\tMaterials Analysis and Characterizations: TEM, SEM, XPS, FT-IR, Raman, DSC, DMA, TGA, XRD, GPC, Fluoroscopy, \r\n5.\tInteraction of Radiation with Mater, Nuclear Safety and Security, NDT(RT),\r\n6.\tRadiation Detectors, Calibration (SSDL),\r\n7.\tCompleted IAEA e-learning Courses:\r\nNuclear Security (15 Modules),\r\nNuclear Safety:\r\nTSA 2: Regulatory Protection in Occupational Exposure,\r\nTips & Tricks: Radiation Protection in Radiography,\r\nSafety and Quality in Radiotherapy,\r\nCourse on Sealed Radioactive Sources,\r\nCourse on Fundamentals of Environmental Remediation,\r\nCourse on Planning for Environmental Remediation,\r\nKnowledge Management Orientation Course,\r\nFood Irradiation - Technology, Applications and Good Practices,\r\nEmployment:\r\nFrom 2010 to now: Academic staff, Nuclear Science and Technology Research Institute, Kargar Shomali, Tehran, Iran, P.O. Box: 14395-836.\r\nFrom 1997 to 2006: Expert of Materials Analysis and Characterization. Research Center of Agriculture and Medicine. Rajaeeshahr, Karaj, Iran, P. O. Box: 31585-498.",institutionString:"Atomic Energy Organization of Iran",institution:{name:"Atomic Energy Organization of Iran",country:{name:"Iran"}}},{id:"248279",title:"Dr.",name:"Monika",middleName:"Elzbieta",surname:"Machoy",slug:"monika-machoy",fullName:"Monika Machoy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248279/images/system/248279.jpeg",biography:"Monika Elżbieta Machoy, MD, graduated with distinction from the Faculty of Medicine and Dentistry at the Pomeranian Medical University in 2009, defended her PhD thesis with summa cum laude in 2016 and is currently employed as a researcher at the Department of Orthodontics of the Pomeranian Medical University. She expanded her professional knowledge during a one-year scholarship program at the Ernst Moritz Arndt University in Greifswald, Germany and during a three-year internship at the Technical University in Dresden, Germany. She has been a speaker at numerous orthodontic conferences, among others, American Association of Orthodontics, European Orthodontic Symposium and numerous conferences of the Polish Orthodontic Society. She conducts research focusing on the effect of orthodontic treatment on dental and periodontal tissues and the causes of pain in orthodontic patients.",institutionString:"Pomeranian Medical University",institution:{name:"Pomeranian Medical University",country:{name:"Poland"}}},{id:"252743",title:"Prof.",name:"Aswini",middleName:"Kumar",surname:"Kar",slug:"aswini-kar",fullName:"Aswini Kar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252743/images/10381_n.jpg",biography:"uploaded in cv",institutionString:null,institution:{name:"KIIT University",country:{name:"India"}}},{id:"204256",title:"Dr.",name:"Anil",middleName:"Kumar",surname:"Kumar Sahu",slug:"anil-kumar-sahu",fullName:"Anil Kumar Sahu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204256/images/14201_n.jpg",biography:"I have nearly 11 years of research and teaching experience. I have done my master degree from University Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur, Chhattisgarh India. I have published 16 review and research articles in international and national journals and published 4 chapters in IntechOpen, the world’s leading publisher of Open access books. I have presented many papers at national and international conferences. I have received research award from Indian Drug Manufacturers Association in year 2015. My research interest extends from novel lymphatic drug delivery systems, oral delivery system for herbal bioactive to formulation optimization.",institutionString:null,institution:{name:"Chhattisgarh Swami Vivekanand Technical University",country:{name:"India"}}},{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",biography:"An assistant professor at Department of Biomedical Computer Systems, at Institute of Computer Science, Silesian University in Katowice. Scientific interests: computer analysis and processing of images, biomedical images, databases and programming languages. He is an author and co-author of scientific publications covering analysis and processing of biomedical images and development of database systems.",institutionString:"University of Silesia",institution:{name:"University of Silesia",country:{name:"Poland"}}},{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",biography:"Dr. Hadi Mohammadi is a biomedical engineer with hands-on experience in the design and development of many engineering structures and medical devices through various projects that he has been involved in over the past twenty years. Dr. Mohammadi received his BSc. and MSc. degrees in Mechanical Engineering from Sharif University of Technology, Tehran, Iran, and his PhD. degree in Biomedical Engineering (biomaterials) from the University of Western Ontario. He was a postdoctoral trainee for almost four years at University of Calgary and Harvard Medical School. He is an industry innovator having created the technology to produce lifelike synthetic platforms that can be used for the simulation of almost all cardiovascular reconstructive surgeries. He’s been heavily involved in the design and development of cardiovascular devices and technology for the past 10 years. He is currently an Assistant Professor with the University of British Colombia, Canada.",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",country:{name:"Canada"}}},{id:"254463",title:"Prof.",name:"Haisheng",middleName:null,surname:"Yang",slug:"haisheng-yang",fullName:"Haisheng Yang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/254463/images/system/254463.jpeg",biography:"Haisheng Yang, Ph.D., Professor and Director of the Department of Biomedical Engineering, College of Life Science and Bioengineering, Beijing University of Technology. He received his Ph.D. degree in Mechanics/Biomechanics from Harbin Institute of Technology (jointly with University of California, Berkeley). Afterwards, he worked as a Postdoctoral Research Associate in the Purdue Musculoskeletal Biology and Mechanics Lab at the Department of Basic Medical Sciences, Purdue University, USA. He also conducted research in the Research Centre of Shriners Hospitals for Children-Canada at McGill University, Canada. Dr. Yang has over 10 years research experience in orthopaedic biomechanics and mechanobiology of bone adaptation and regeneration. He earned an award from Beijing Overseas Talents Aggregation program in 2017 and serves as Beijing Distinguished Professor.",institutionString:null,institution:{name:"Beijing University of Technology",country:{name:"China"}}},{id:"89721",title:"Dr.",name:"Mehmet",middleName:"Cuneyt",surname:"Ozmen",slug:"mehmet-ozmen",fullName:"Mehmet Ozmen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/89721/images/7289_n.jpg",biography:null,institutionString:null,institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"265335",title:"Mr.",name:"Stefan",middleName:"Radnev",surname:"Stefanov",slug:"stefan-stefanov",fullName:"Stefan Stefanov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/265335/images/7562_n.jpg",biography:null,institutionString:null,institution:{name:"Medical University Plovdiv",country:{name:"Bulgaria"}}},{id:"242893",title:"Ph.D. Student",name:"Joaquim",middleName:null,surname:"De Moura",slug:"joaquim-de-moura",fullName:"Joaquim De Moura",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/242893/images/7133_n.jpg",biography:"Joaquim de Moura received his degree in Computer Engineering in 2014 from the University of A Coruña (Spain). In 2016, he received his M.Sc degree in Computer Engineering from the same university. He is currently pursuing his Ph.D degree in Computer Science in a collaborative project between ophthalmology centers in Galicia and the University of A Coruña. His research interests include computer vision, machine learning algorithms and analysis and medical imaging processing of various kinds.",institutionString:null,institution:{name:"University of A Coruña",country:{name:"Spain"}}},{id:"294334",title:"B.Sc.",name:"Marc",middleName:null,surname:"Bruggeman",slug:"marc-bruggeman",fullName:"Marc Bruggeman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/294334/images/8242_n.jpg",biography:"Chemical engineer graduate, with a passion for material science and specific interest in polymers - their near infinite applications intrigue me. \n\nI plan to continue my scientific career in the field of polymeric biomaterials as I am fascinated by intelligent, bioactive and biomimetic materials for use in both consumer and medical applications.",institutionString:null,institution:null},{id:"255757",title:"Dr.",name:"Igor",middleName:"Victorovich",surname:"Lakhno",slug:"igor-lakhno",fullName:"Igor Lakhno",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255757/images/system/255757.jpg",biography:"Igor Victorovich Lakhno was born in 1971 in Kharkiv (Ukraine). \nMD – 1994, Kharkiv National Medical Univesity.\nOb&Gyn; – 1997, master courses in Kharkiv Medical Academy of Postgraduate Education.\nPh.D. – 1999, Kharkiv National Medical Univesity.\nDSC – 2019, PL Shupik National Academy of Postgraduate Education \nProfessor – 2021, Department of Obstetrics and Gynecology of VN Karazin Kharkiv National University\nHead of Department – 2021, Department of Perinatology, Obstetrics and gynecology of Kharkiv Medical Academy of Postgraduate Education\nIgor Lakhno has been graduated from international training courses on reproductive medicine and family planning held at Debrecen University (Hungary) in 1997. Since 1998 Lakhno Igor has worked as an associate professor in the department of obstetrics and gynecology of VN Karazin National University and an associate professor of the perinatology, obstetrics, and gynecology department of Kharkiv Medical Academy of Postgraduate Education. Since June 2019 he’s been a professor in the department of obstetrics and gynecology of VN Karazin National University and a professor of the perinatology, obstetrics, and gynecology department. He’s affiliated with Kharkiv Medical Academy of Postgraduate Education as a Head of Department from November 2021. Igor Lakhno has participated in several international projects on fetal non-invasive electrocardiography (with Dr. J. A. Behar (Technion), Prof. D. Hoyer (Jena University), and José Alejandro Díaz Méndez (National Institute of Astrophysics, Optics, and Electronics, Mexico). He’s an author of about 200 printed works and there are 31 of them in Scopus or Web of Science databases. Igor Lakhno is a member of the Editorial Board of Reproductive Health of Woman, Emergency Medicine, and Technology Transfer Innovative Solutions in Medicine (Estonia). He is a medical Editor of “Z turbotoyu pro zhinku”. Igor Lakhno is a reviewer of the Journal of Obstetrics and Gynaecology (Taylor and Francis), British Journal of Obstetrics and Gynecology (Wiley), Informatics in Medicine Unlocked (Elsevier), The Journal of Obstetrics and Gynecology Research (Wiley), Endocrine, Metabolic & Immune Disorders-Drug Targets (Bentham Open), The Open Biomedical Engineering Journal (Bentham Open), etc. He’s defended a dissertation for a DSc degree “Pre-eclampsia: prediction, prevention, and treatment”. Three years ago Igor Lakhno has participated in a training course on innovative technologies in medical education at Lublin Medical University (Poland). Lakhno Igor has participated as a speaker in several international conferences and congresses (International Conference on Biological Oscillations April 10th-14th 2016, Lancaster, UK, The 9th conference of the European Study Group on Cardiovascular Oscillations). His main scientific interests: are obstetrics, women’s health, fetal medicine, and cardiovascular medicine. \nIgor Lakhno is a consultant at Kharkiv municipal perinatal center. He’s graduated from training courses on endoscopy in gynecology. He has 28 years of practical experience in the field.",institutionString:null,institution:null},{id:"244950",title:"Dr.",name:"Salvatore",middleName:null,surname:"Di Lauro",slug:"salvatore-di-lauro",fullName:"Salvatore Di Lauro",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0030O00002bSF1HQAW/ProfilePicture%202021-12-20%2014%3A54%3A14.482",biography:"Name:\n\tSALVATORE DI LAURO\nAddress:\n\tHospital Clínico Universitario Valladolid\nAvda Ramón y Cajal 3\n47005, Valladolid\nSpain\nPhone number: \nFax\nE-mail:\n\t+34 983420000 ext 292\n+34 983420084\nsadilauro@live.it\nDate and place of Birth:\nID Number\nMedical Licence \nLanguages\t09-05-1985. Villaricca (Italy)\n\nY1281863H\n474707061\nItalian (native language)\nSpanish (read, written, spoken)\nEnglish (read, written, spoken)\nPortuguese (read, spoken)\nFrench (read)\n\t\t\nCurrent position (title and company)\tDate (Year)\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. Private practise.\t2017-today\n\n2019-today\n\t\n\t\nEducation (High school, university and postgraduate training > 3 months)\tDate (Year)\nDegree in Medicine and Surgery. University of Neaples 'Federico II”\nResident in Opthalmology. Hospital Clinico Universitario Valladolid\nMaster in Vitreo-Retina. IOBA. University of Valladolid\nFellow of the European Board of Ophthalmology. Paris\nMaster in Research in Ophthalmology. University of Valladolid\t2003-2009\n2012-2016\n2016-2017\n2016\n2012-2013\n\t\nEmployments (company and positions)\tDate (Year)\nResident in Ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl.\nFellow in Vitreo-Retina. IOBA. University of Valladolid\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. \n\t2012-2016\n2016-2017\n2017-today\n\n2019-Today\n\n\n\t\nClinical Research Experience (tasks and role)\tDate (Year)\nAssociated investigator\n\n' FIS PI20/00740: DESARROLLO DE UNA CALCULADORA DE RIESGO DE\nAPARICION DE RETINOPATIA DIABETICA BASADA EN TECNICAS DE IMAGEN MULTIMODAL EN PACIENTES DIABETICOS TIPO 1. Grant by: Ministerio de Ciencia e Innovacion \n\n' (BIO/VA23/14) Estudio clínico multicéntrico y prospectivo para validar dos\nbiomarcadores ubicados en los genes p53 y MDM2 en la predicción de los resultados funcionales de la cirugía del desprendimiento de retina regmatógeno. Grant by: Gerencia Regional de Salud de la Junta de Castilla y León.\n' Estudio multicéntrico, aleatorizado, con enmascaramiento doble, en 2 grupos\nparalelos y de 52 semanas de duración para comparar la eficacia, seguridad e inmunogenicidad de SOK583A1 respecto a Eylea® en pacientes con degeneración macular neovascular asociada a la edad' (CSOK583A12301; N.EUDRA: 2019-004838-41; FASE III). Grant by Hexal AG\n\n' Estudio de fase III, aleatorizado, doble ciego, con grupos paralelos, multicéntrico para comparar la eficacia y la seguridad de QL1205 frente a Lucentis® en pacientes con degeneración macular neovascular asociada a la edad. (EUDRACT: 2018-004486-13). Grant by Qilu Pharmaceutical Co\n\n' Estudio NEUTON: Ensayo clinico en fase IV para evaluar la eficacia de aflibercept en pacientes Naive con Edema MacUlar secundario a Oclusion de Vena CenTral de la Retina (OVCR) en regimen de tratamientO iNdividualizado Treat and Extend (TAE)”, (2014-000975-21). Grant by Fundacion Retinaplus\n\n' Evaluación de la seguridad y bioactividad de anillos de tensión capsular en conejo. Proyecto Procusens. Grant by AJL, S.A.\n\n'Estudio epidemiológico, prospectivo, multicéntrico y abierto\\npara valorar la frecuencia de la conjuntivitis adenovírica diagnosticada mediante el test AdenoPlus®\\nTest en pacientes enfermos de conjuntivitis aguda”\\n. National, multicenter study. Grant by: NICOX.\n\nEuropean multicentric trial: 'Evaluation of clinical outcomes following the use of Systane Hydration in patients with dry eye”. Study Phase 4. Grant by: Alcon Labs'\n\nVLPs Injection and Activation in a Rabbit Model of Uveal Melanoma. Grant by Aura Bioscience\n\nUpdating and characterization of a rabbit model of uveal melanoma. Grant by Aura Bioscience\n\nEnsayo clínico en fase IV para evaluar las variantes genéticas de la vía del VEGF como biomarcadores de eficacia del tratamiento con aflibercept en pacientes con degeneración macular asociada a la edad (DMAE) neovascular. Estudio BIOIMAGE. IMO-AFLI-2013-01\n\nEstudio In-Eye:Ensayo clínico en fase IV, abierto, aleatorizado, de 2 brazos,\nmulticçentrico y de 12 meses de duración, para evaluar la eficacia y seguridad de un régimen de PRN flexible individualizado de 'esperar y extender' versus un régimen PRN según criterios de estabilización mediante evaluaciones mensuales de inyecciones intravítreas de ranibizumab 0,5 mg en pacientes naive con neovascularización coriodea secunaria a la degeneración macular relacionada con la edad. CP: CRFB002AES03T\n\nTREND: Estudio Fase IIIb multicéntrico, randomizado, de 12 meses de\nseguimiento con evaluador de la agudeza visual enmascarado, para evaluar la eficacia y la seguridad de ranibizumab 0.5mg en un régimen de tratar y extender comparado con un régimen mensual, en pacientes con degeneración macular neovascular asociada a la edad. CP: CRFB002A2411 Código Eudra CT:\n2013-002626-23\n\n\n\nPublications\t\n\n2021\n\n\n\n\n2015\n\n\n\n\n2021\n\n\n\n\n\n2021\n\n\n\n\n2015\n\n\n\n\n2015\n\n\n2014\n\n\n\n\n2015-16\n\n\n\n2015\n\n\n2014\n\n\n2014\n\n\n\n\n2014\n\n\n\n\n\n\n\n2014\n\nJose Carlos Pastor; Jimena Rojas; Salvador Pastor-Idoate; Salvatore Di Lauro; Lucia Gonzalez-Buendia; Santiago Delgado-Tirado. Proliferative vitreoretinopathy: A new concept of disease pathogenesis and practical\nconsequences. Progress in Retinal and Eye Research. 51, pp. 125 - 155. 03/2016. DOI: 10.1016/j.preteyeres.2015.07.005\n\n\nLabrador-Velandia S; Alonso-Alonso ML; Di Lauro S; García-Gutierrez MT; Srivastava GK; Pastor JC; Fernandez-Bueno I. Mesenchymal stem cells provide paracrine neuroprotective resources that delay degeneration of co-cultured organotypic neuroretinal cultures.Experimental Eye Research. 185, 17/05/2019. DOI: 10.1016/j.exer.2019.05.011\n\nSalvatore Di Lauro; Maria Teresa Garcia Gutierrez; Ivan Fernandez Bueno. Quantification of pigment epithelium-derived factor (PEDF) in an ex vivo coculture of retinal pigment epithelium cells and neuroretina.\nJournal of Allbiosolution. 2019. ISSN 2605-3535\n\nSonia Labrador Velandia; Salvatore Di Lauro; Alonso-Alonso ML; Tabera Bartolomé S; Srivastava GK; Pastor JC; Fernandez-Bueno I. Biocompatibility of intravitreal injection of human mesenchymal stem cells in immunocompetent rabbits. Graefe's archive for clinical and experimental ophthalmology. 256 - 1, pp. 125 - 134. 01/2018. DOI: 10.1007/s00417-017-3842-3\n\n\nSalvatore Di Lauro, David Rodriguez-Crespo, Manuel J Gayoso, Maria T Garcia-Gutierrez, J Carlos Pastor, Girish K Srivastava, Ivan Fernandez-Bueno. A novel coculture model of porcine central neuroretina explants and retinal pigment epithelium cells. Molecular Vision. 2016 - 22, pp. 243 - 253. 01/2016.\n\nSalvatore Di Lauro. Classifications for Proliferative Vitreoretinopathy ({PVR}): An Analysis of Their Use in Publications over the Last 15 Years. Journal of Ophthalmology. 2016, pp. 1 - 6. 01/2016. DOI: 10.1155/2016/7807596\n\nSalvatore Di Lauro; Rosa Maria Coco; Rosa Maria Sanabria; Enrique Rodriguez de la Rua; Jose Carlos Pastor. Loss of Visual Acuity after Successful Surgery for Macula-On Rhegmatogenous Retinal Detachment in a Prospective Multicentre Study. Journal of Ophthalmology. 2015:821864, 2015. DOI: 10.1155/2015/821864\n\nIvan Fernandez-Bueno; Salvatore Di Lauro; Ivan Alvarez; Jose Carlos Lopez; Maria Teresa Garcia-Gutierrez; Itziar Fernandez; Eva Larra; Jose Carlos Pastor. Safety and Biocompatibility of a New High-Density Polyethylene-Based\nSpherical Integrated Porous Orbital Implant: An Experimental Study in Rabbits. Journal of Ophthalmology. 2015:904096, 2015. DOI: 10.1155/2015/904096\n\nPastor JC; Pastor-Idoate S; Rodríguez-Hernandez I; Rojas J; Fernandez I; Gonzalez-Buendia L; Di Lauro S; Gonzalez-Sarmiento R. Genetics of PVR and RD. Ophthalmologica. 232 - Suppl 1, pp. 28 - 29. 2014\n\nRodriguez-Crespo D; Di Lauro S; Singh AK; Garcia-Gutierrez MT; Garrosa M; Pastor JC; Fernandez-Bueno I; Srivastava GK. Triple-layered mixed co-culture model of RPE cells with neuroretina for evaluating the neuroprotective effects of adipose-MSCs. Cell Tissue Res. 358 - 3, pp. 705 - 716. 2014.\nDOI: 10.1007/s00441-014-1987-5\n\nCarlo De Werra; Salvatore Condurro; Salvatore Tramontano; Mario Perone; Ivana Donzelli; Salvatore Di Lauro; Massimo Di Giuseppe; Rosa Di Micco; Annalisa Pascariello; Antonio Pastore; Giorgio Diamantis; Giuseppe Galloro. Hydatid disease of the liver: thirty years of surgical experience.Chirurgia italiana. 59 - 5, pp. 611 - 636.\n(Italia): 2007. ISSN 0009-4773\n\nChapters in books\n\t\n' Salvador Pastor Idoate; Salvatore Di Lauro; Jose Carlos Pastor Jimeno. PVR: Pathogenesis, Histopathology and Classification. Proliferative Vitreoretinopathy with Small Gauge Vitrectomy. Springer, 2018. ISBN 978-3-319-78445-8\nDOI: 10.1007/978-3-319-78446-5_2. \n\n' Salvatore Di Lauro; Maria Isabel Lopez Galvez. Quistes vítreos en una mujer joven. Problemas diagnósticos en patología retinocoroidea. Sociedad Española de Retina-Vitreo. 2018.\n\n' Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor Jimeno. iOCT in PVR management. OCT Applications in Opthalmology. pp. 1 - 8. INTECH, 2018. DOI: 10.5772/intechopen.78774.\n\n' Rosa Coco Martin; Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor. amponadores, manipuladores y tinciones en la cirugía del traumatismo ocular.Trauma Ocular. Ponencia de la SEO 2018..\n\n' LOPEZ GALVEZ; DI LAURO; CRESPO. OCT angiografia y complicaciones retinianas de la diabetes. PONENCIA SEO 2021, CAPITULO 20. (España): 2021.\n\n' Múltiples desprendimientos neurosensoriales bilaterales en paciente joven. Enfermedades Degenerativas De Retina Y Coroides. SERV 04/2016. \n' González-Buendía L; Di Lauro S; Pastor-Idoate S; Pastor Jimeno JC. Vitreorretinopatía proliferante (VRP) e inflamación: LA INFLAMACIÓN in «INMUNOMODULADORES Y ANTIINFLAMATORIOS: MÁS ALLÁ DE LOS CORTICOIDES. 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