These books synthesize perspectives of renowned scientists from the world’s most prestigious institutions - from Fukushima Renewable Energy Institute in Japan to Stanford University in the United States, including Columbia University (US), University of Sidney (AU), University of Miami (USA), Cardiff University (UK), and many others.
\\n\\n
This collaboration embodied the true essence of Open Access by simplifying the approach to OA publishing for Academic editors and authors who contributed their research and allowed the new research to be made available free and open to anyone anywhere in the world.
\\n\\n
To celebrate the 50 books published, we have gathered them at one location - just one click away, so that you can easily browse the subjects of your interest, download the content directly, share it or read online.
IntechOpen and Knowledge Unlatched formed a partnership to support researchers working in engineering sciences by enabling an easier approach to publishing Open Access content. Using the Knowledge Unlatched crowdfunding model to raise the publishing costs through libraries around the world, Open Access Publishing Fee (OAPF) was not required from the authors.
\n\n
Initially, the partnership supported engineering research, but it soon grew to include physical and life sciences, attracting more researchers to the advantages of Open Access publishing.
\n\n\n\n
These books synthesize perspectives of renowned scientists from the world’s most prestigious institutions - from Fukushima Renewable Energy Institute in Japan to Stanford University in the United States, including Columbia University (US), University of Sidney (AU), University of Miami (USA), Cardiff University (UK), and many others.
\n\n
This collaboration embodied the true essence of Open Access by simplifying the approach to OA publishing for Academic editors and authors who contributed their research and allowed the new research to be made available free and open to anyone anywhere in the world.
\n\n
To celebrate the 50 books published, we have gathered them at one location - just one click away, so that you can easily browse the subjects of your interest, download the content directly, share it or read online.
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He divides his time between his clinic, the University and short travels for international meetings, live surgery demonstrations and hands-on courses in countries of all continents. \r\nHe is editor and author of several comprehensive textbooks in the field of Cosmetic and Plastic Surgery, including Liposuction, Sutures Lifts on Face and Body Areas, Thread vs Suture lift techniques, Rhinoplasty and has authored many chapters in aesthetic surgery and medicine books, as well as original papers in medical journals.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"20",totalChapterViews:"0",totalEditedBooks:"5",institution:null}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"1211",title:"Toxinology",slug:"pharmacology-toxicology-and-pharmaceutical-science-toxicology-toxinology"}],chapters:[{id:"62361",title:"Botulinum Toxins, Diversity, Mode of Action, Epidemiology of Botulism in France",slug:"botulinum-toxins-diversity-mode-of-action-epidemiology-of-botulism-in-france",totalDownloads:1476,totalCrossrefCites:3,authors:[{id:"250271",title:"Dr.",name:"Michel",surname:"Popoff",slug:"michel-popoff",fullName:"Michel Popoff"}]},{id:"62848",title:"Botulinum Toxin Adverse Events",slug:"botulinum-toxin-adverse-events",totalDownloads:1687,totalCrossrefCites:2,authors:[{id:"250248",title:"Prof.",name:"Raffaela",surname:"Pero",slug:"raffaela-pero",fullName:"Raffaela Pero"},{id:"264467",title:"Prof.",name:"Sonia",surname:"Laneri",slug:"sonia-laneri",fullName:"Sonia Laneri"},{id:"264468",title:"Dr.",name:"Giovanna",surname:"Fico",slug:"giovanna-fico",fullName:"Giovanna Fico"}]},{id:"63468",title:"Experimental Comparative Effects of Botulinum Toxin A between Subtypes A1 and A2 in Movement Disorders in Rats",slug:"experimental-comparative-effects-of-botulinum-toxin-a-between-subtypes-a1-and-a2-in-movement-disorde",totalDownloads:1020,totalCrossrefCites:0,authors:[{id:"221540",title:"Associate Prof.",name:"Hidemitsu",surname:"Nakajima",slug:"hidemitsu-nakajima",fullName:"Hidemitsu Nakajima"},{id:"251147",title:"Dr.",name:"Tomoko",surname:"Kohda",slug:"tomoko-kohda",fullName:"Tomoko Kohda"},{id:"252690",title:"Dr.",name:"Yasushi",surname:"Torii",slug:"yasushi-torii",fullName:"Yasushi Torii"}]},{id:"62524",title:"Adjuvant Botulinum Toxin Harmonisation in Minimally Invasive Facial Aesthetic Surgery",slug:"adjuvant-botulinum-toxin-harmonisation-in-minimally-invasive-facial-aesthetic-surgery",totalDownloads:1014,totalCrossrefCites:0,authors:[{id:"151273",title:"Dr.",name:"Ronald",surname:"Feiner",slug:"ronald-feiner",fullName:"Ronald Feiner"},{id:"151341",title:"Dr.",name:"Chedly",surname:"Bouzouaya",slug:"chedly-bouzouaya",fullName:"Chedly Bouzouaya"}]},{id:"62650",title:"Masseter Hypertrophy: Toxin Treatment Techniques, Causes of Complications, and Prevention",slug:"masseter-hypertrophy-toxin-treatment-techniques-causes-of-complications-and-prevention",totalDownloads:2130,totalCrossrefCites:0,authors:[{id:"248440",title:"M.D.",name:"Hsien Li Peter",surname:"Peng",slug:"hsien-li-peter-peng",fullName:"Hsien Li Peter Peng"}]},{id:"62007",title:"Botulinum Toxin in Dentistry",slug:"botulinum-toxin-in-dentistry",totalDownloads:1742,totalCrossrefCites:1,authors:[{id:"249415",title:"Dr.",name:"Diana",surname:"Mostafa",slug:"diana-mostafa",fullName:"Diana Mostafa"}]},{id:"62222",title:"Botulinum Toxin for the Treatment of Chronic Migraines",slug:"botulinum-toxin-for-the-treatment-of-chronic-migraines",totalDownloads:1244,totalCrossrefCites:0,authors:[{id:"247134",title:"M.D.",name:"Alberto J.",surname:"Kalach-Mussali",slug:"alberto-j.-kalach-mussali",fullName:"Alberto J. 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Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"57069",title:"The Effect of Working Capital Management on Profitability in Emerging Countries: Evidence from Turkey",doi:"10.5772/intechopen.70871",slug:"the-effect-of-working-capital-management-on-profitability-in-emerging-countries-evidence-from-turkey",body:'\n
\n
1. Introduction
\n
Global economic integration for developing countries through economic liberalization and democratization is accepted as the best way to overcome destitution and discrimination [1]. At this point, the industry sector plays a significant role. According to the World Bank data, the share of the industry sector in the gross domestic product (GDP) of emerging countries such as China, India, and Brazil in 2016 is 40, 29, and 21%, respectively [2]. For Turkey, which is among the emerging countries, the industry sector is important for the country economy in terms of value added export and employment [3]. According to the World Bank data, the industry sector’s share in GDP is 32% [2]. The share of the industry sector in exports is around 92% [4]. In this case, the industry sector will remain important for the Turkish economy in the future.
\n
The industry sector, which plays a key role in the Turkish economy, is faced with many problems such as lack of qualified workforce, inadequacy of infrastructure and technology, weak competition power, and difficulties in marketing and financing. The financing problem is one of the most important problems faced by these firms. These firms need to be able to use their existing resources effectively and be self-sufficient because of the scarcity of funding resources and the insufficient accumulation of capital. Working capital, which is seen as the lifeblood of a business, has an important role in the return of the owner’s reckoning, and has a decisive influence on liquidity [5], is important at this point.
\n
Firms need working capital to begin its business operations, carry on its activities efficiently, and meet its short run obligations [6]. Working capital management is concerned with the day-to-day activities rather than long-term investment decisions [7]. Working capital is a part of firm’s current assets, which are converted into cash within a year or less [8]. In this sense, working capital components (WCC) are cash, cash equivalents, inventories, accounts receivables, and accounts payables.
\n
Investment in the working capital components is important for all industrial enterprises to be powerful financially. A firm can collect its receivables in a short time and restrict credit sales to reduce account receivables and increase cash inflows. However, rigid sales policies and low credit sales would lead to loss of sales, thus causing profits to fall [6]. On the other hand, high inventory levels and flexible credit sales policy can contribute to increased sales. Because sales on credit allow the customer to examine the product before paying, it may increase sales [9]. There are some advantages to work with high inventory levels such as preventing customer losses caused by not having enough stock level and protecting against price volatilities [10]. However, the high inventory and loose trade credit policies lead to the locking of the money to the working capital [9]. In this context, firms that invest heavily in inventory and accounts receivables may be exposed to low profits [11]. Another component that has an impact on the working capital requirement is accounts payables. Deferment of payments to suppliers can enable the firm to evaluate the product bought and may be a cheap and flexible funding source. But, postponing payments can be expensive, if the firm has got a discount for early payment [9]. In this case, the level of accounts payables of the firm may affect the firm’s profitability.
\n
The style of WCM may have a considerable influence on the profitability, risk, and liquidity of the firm [12]. The firm that invests more in current assets is more liquid than a firm that does not invest. This will reduce the firm’s liquidity risk, while decreasing overall rate of return, because the return of current assets is less than the return of other assets [13]. While lower investment in the working capital expressed as aggressive working capital policy is associated with higher returns and higher risk, more investment in the working capital expressed as conservative working capital policy is associated with lower return and lower risk [14]. The firm has to choose between aggressive and conservative working capital policies depending on its purpose [15].
\n
Effective WCM is a significant factor affecting the survival of the firm, the continuity of its activities, and the maintenance of liquidity and profitability [16]. Excessive working capital like inadequate working capital has led many businesses to fail and prevent their growth [17]. WCM is important due to the effect on profitability of firm, firm’s risk, and the firm value [18]. In this context, this study aims to reveal the tradeoff between WCC and firm’s profitability by using the data of the firms listed on Borsa Istanbul (BIST) Industry Index in Turkey.
\n
This study, which investigates the impact of the WCM on the profitability of Turkish industrial firms, is considered to contribute on the determination of working capital investment levels of these firms, determination of the distribution among the working capital components, effective use of scarce resources, and resource supply and sustainability of future investments by applying a working capital that will increase the profitability. There are a number of studies covering the developed countries in the literature, while there are limited studies covering the emerging countries. It is anticipated that the study will contribute to the literature in terms of comparing the relationship between the WCM and profitability of industrial firms of emerging countries like Turkey. It is thought that the study with these aspects will be beneficial to both managers and researchers.
\n
\n
\n
2. Literature review
\n
There are studies in the literature that examine WCC-firm’s profitability tradeoff in terms of different countries and different sectors. The findings obtained from these studies vary depending on the method and data set used. Some of these studies are summarized in \nTable 1\n.
\nDependent variables: Profit before tax to total assets ratio \nIndependent variables: Current ratio, liquid ratio, working capital ratio, inventory turnover ratio, receivables turnover ratio and working capital to total assets
\n
Correlation analysis and a multivariate regression model
\n
Findings show that the working capital components are related to profitability of Hindalco Industries Limited
Firms in the manufacturing sector listed on BIST in Turkey
\n
\nDependent variables: Gross profit ratio \nIndependent variables: The number of days accounts receivable, the number of days of inventory, the number of days accounts payable and net trade cycle \nControl variables: Financial fixed assets, sales growth, financial liabilities
\n
Panel regression analysis
\n
The relationship between the profitability and inventory turnover ratio, receivables turnover ratio, payable deferral period and net trade cycle is negative
\nDependent variables: Return on assets, return on sales and return on equity \nIndependent variables: Cash conversion efficiency, debt ratio, days of working capital, days receivable and days inventory
\n
Multiple linear regression
\n
The study shows a negative relationship for return on assets and return on sales with days inventory. Also return on assets has a negative relationship with debt ratio.
Manufacturing firms listed in Centre for Monitoring Indian Economy
\n
\nDependent variables: The profit before depreciation tax accounts return on assets \nIndependent variables: Debtors days, inventory days, creditors days, cash velocity, working capital policy, net working capital leverage, size, current ratio
\n
Correlation analysis, panel regression analysis
\n
The study shows a positive relationship for inventory days and debtors days with the profitability.
Manufacturing corporations listed on Dhaka Stock Exchange in Bangladesh
\n
\nDependent variables: Return on asset and net profit margin \nIndependent variables: Receivables Collection Period, inventory turnover period, payable deferral period, cash conversion cycle, current ratio and quick ratio
\n
Single regression analysis
\n
The meaningful relationship exists between the firms’ profitability and the working capital components
\nDependent variables: Return on assets, tobin-q \nIndependent variables: Cash conversion cycle, inventory conversion period, account receivable period, accounts payable period and current ratio
\n
Panel regression analysis
\n
Return on assets has a negative relationship with account receivable period and cash conversion cycle while having a positive relationship with current ratio.
Manufacturing firms in Egypt, Kenya, Nigeria and South Africa
\n
\nDependent variables: Net operating profit \nIndependent variables: Number of days accounts payable, number of days inventories, the number of days accounts receivables and cash conversion cycle \nControl variables: firm size board size.
\n
Panel regression analysis
\n
Cash conversion cycles have a negative relationship with net operating profit
\nDependent variables: Firm’s profitability \nIndependent variables: Cash conversion cycle \nControl variables: Sales growth, depth ratio and current ratio
\n
Multivariate regression model
\n
Cash conversion cycle is negatively related to firm’s profitability
Cement firms listed on Karachi Stock Exchange in Pakistan
\n
\nDependent variables: Return on assets \nIndependent variables: Current Ratio, quick ratio, net current assets to total assets, working capital turnover ratio, inventory turnover ratio
\n
Panel regression analysis
\n
Findings show that the working capital components is related to the profitability of cement firms
Manufacturing and conglomerates firms listed in Nigeria
\n
\nDependent variables: Return on assets and return on equity \nIndependent variables: Average payment period, average collection period and inventory turnover period \nControl variables: Firms’ size and leverage
\n
Panel regression analysis
\n
Working capital components except inventory turnover are significant determinants of firm’s profitability. Also the negative relationship is observed between average collection period and profitability
Firms in Cement Industries listed on Bombay Stock Exchange in India
\n
\nDependent variables: Return on Investment \nIndependent variables: Working capital turnover ratio, fixed asset turnover ratio, debtors turnover ratio, inventory turnover ratio, quick ratio, current ratio, firm’s size, leverage ratio
\n
Multiple regression analysis
\n
There is not a significant effect of working capital ratio, debtor’s turnover ratio, fixed assets turnovers ratio, inventory turnover ratio except current ratio, quick ratio on return on investment
\nDependent variables: Return on assets \nIndependent variables: The number of days accounts receivables, the number of days of inventories, the number of days accounts payable, cash conversion cycle \nControl variables: Current ratio, firm’s size, leverage ratio
\n
Panel regression analysis
\n
The number of days accounts receivables and current ratio have a negative and meaningful effect on firms’ profitability. But the negative insignificant effect is observed between cash conversion cycle and firms’ profitability
\n
\n\n
Table 1.
Overview of the studies about WCC-firm’s profitability tradeoff.
\n
\n
\n
3. Methodology
\n
In the study, the impact of WCM on profitability is analyzed via panel data regression model. The panel data models, which allow more consistent estimation results by including both time and cross-sectional properties, are modeled in different ways according to effect of the cross section and time properties [30]. In this context, the models in which both constant and slope parameters are constant with respect to cross section and time unit are called as pooled panel data models and are defined as follows:
The subscript i in the model is a cross-sectional unit such as an individual or a firm; t represents the time dimension. Yit\n is the dependent variable, and Xkit\n denotes k independent variables with cross sectional unit i and time t. In the model, αk\n is the vector of the (kx1) size parameter that does not vary according to the i cross-section unit and time dimension, and α\n0 is also the constant term. eit\n is the error term that is independent and identically distributed with 0 mean and σ\n2 variance for all i cross-section units and t time periods (IID) [31].
\n
If both the time and the cross-section are affecting the model, the panel data model takes the name of the two-way panel data model. The model is called as a one-way panel data model if the effect is only a cross-sectional unit or a time effect.
\n
In the case where unit and/or time effect cause changes in some or all of the parameters of the model, the panel data models are named fixed effects panel data model. If the fixed effects model is one way, model is shown as following:
Similar to previous model, Yit\n is the dependent variable and Xkit\n denotes k independent variables with cross sectional unit i and time t. αi\n is the individual specific coefficients for the cross-sectional unit, while the t time dimension is constant. Similarly, α\n\nk is the vector of the (kx1) size parameter that does not vary according to the i cross-section unit and t time dimension. The model is also named as covariance model or dummy variables model. Unobserved individual effects are achieved by using specific dummy variables:
\nDN\n is the vector of dummy variables [30]. If the model contains both cross section and time effects, the two-way fixed effect model is determined as the following model:
\nXit\n is the vector of independent variables. In the two-way fixed effects models, μi\n is the individual specific coefficients, λt\n is the time effects, and β is also the vector of coefficients [30].
\n
The model in which the cross section and/or time effect is included as a component of the model error term is defined as the random effects model. If the random effects model is one way, model is generally expressed as:
As explained in the fixed effects model, Yit\n is dependent variable, and Xit\n is the vector of independent variables. Individual effects consist of a combination of α\n0, which does not have unit and time effects, and μi\n, which contains the specific cross section effects. The cross section effects and eit\n error term are added to the model as a component of uit\n error term, and the model is predicted with act of knowledge [31]. If both the specific unit effects μi\n and the specific time effects λt\n are expressed as a component of the error term eit\n, the two-way random effects model is mentioned. The two-way random effects model is determined as,
The Hausman (1978) test determines whether the fixed effects model or the random effects model is appropriate for panel data analysis [31]. Hausman suggests that the null hypothesis for the test is an appropriate model of the random effects model, which implies that there is no relationship between cross section and explanatory variables [32]. The alternative hypothesis indicates that the appropriate model is the fixed effect model. Hausman test statistic (H) is estimated by the following formula using the variance covariance matrix:
Hausman test statistics fits the asymptotic χ2 distribution with parameter k. V is the variance covariance matrix of the difference between the estimators. \n\n\n\nβ\n̂\n\nFE\n\n\n and \n\n\n\nβ\n̂\n\nRE\n\n\n are the fixed effects and random effects estimators, respectively. As a result of the analysis, it is determined whether the predicted model is a fixed effects model or a random effects model [30].
\n
\n
\n
4. Data and variables
\n
In this study, the tradeoff between WCC and firm’s profitability is examined via the annual data for the period 2005–2016 of 41 firms listed on BIST Industrial Index in Turkey. In order to examine WCC firm’s profitability tradeoff, dependent variable is defined as return on assets (ROA); independent variables are cash conversion cycle (CCC), inventory conversion period (ICP), payables deferral period (PDP), and control variables are sales growth (SG), the ratio of short-term financial debts to short-term debts (FDSD), and the ratio of fixed assets to total assets (FATA).
\n
ROA widely used and accepted as measure of profitability [23] indicates the rate of return provided by firm’s assets [13]. CCC measures the effectiveness of the working capital [9, 22]. CCC expresses the time spent between the expenses for purchasing raw materials and the collection of sales [9, 11, 12]. Longer CCC means the more investment in the working capital [9, 11], in other words, the more current asset financing needs [8]. CCC consists of three components: receivables collection period, ICP, and PDP. ICP refers to the time required for the conversion of raw materials to finished goods and then the sale of these products. PDP is the average time firm’s suppliers give it to pay for its purchases [33]. The other component of CCC, receivables collection period, was not included in the study, since this variable was not statistically significant in the models formed. SG, FDSD, and FATA as control variables were also used to increase the reliability level of the models established in the study [34]. All variables and its formulations in the study are shown in \nTable 2\n.
\n
\n
\n
\n
\n\n
\n
\n
Variables
\n
Formulas
\n
\n\n\n
\n
Dependent variables
\n
Return on assets (ROA)
\n
Net profit/total asset
\n
\n
\n
Independent variables
\n
Cash conversion cycle (CCC)
\n
(receivables collection period + inventory conversion period) − payables deferral period
\n
\n
\n
Inventory conversion period (ICP)
\n
(Inventories/cost of goods sold)×365
\n
\n
\n
Payables deferral period (PDP)
\n
Accounts payable/cost of goods sold)×365
\n
\n
\n
Control variables
\n
Sales growth (SG)
\n
Change in sales (%)
\n
\n
\n
The ratio of short-term financial debts to short-term debts (FDSD)
\n
Short-term financial debts/short-term debts
\n
\n
\n
The ratio of fixed assets to total assets (FATA)
\n
Fixed assets/total assets
\n
\n\n
Table 2.
Descriptions of the variables.
\n
\n
\n
5. Empirical results
\n
Panel regression analysis was used to investigate the tradeoff between WCC and the profitability of the 41 firms listed on BIST Industrial Index in Turkey. In the panel data analysis, variables include both time and cross section size. According to time and cross-section effects, it is determined that the model should be predicted to be one way or two ways. For this purpose, the LR test has performed with the maximum likelihood method, and the findings are given in \nTable 3\n. The calculated test statistics are interpreted according to the 1% significance level.
\n
\n
\n
\n
\n
\n\n
\n
Tests
\n
Two-way effects
\n
Cross-section effects
\n
Time effects
\n
\n\n\n
\n
\nχ\n2testi\n
\n
279.1188
\n
262.4951
\n
3.981432
\n
\n
\n
Prob.
\n
0.000
\n
0.000
\n
0.023
\n
\n\n
Table 3.
Test results of cross section and time effects.
\n
For the two-way effects test, the null hypothesis is formed no cross section and time effects in the model. Because the value of the test statistic for the two-way effect is 279.1188 at 1% significance level, the null hypothesis is rejected. This result shows that it is a two-way effect. Then, the presence of the cross section and time effects was tested separately with the movement from the findings that it was a two-way effect. The null hypothesis for cross section effect analysis is that the standard error of cross section is equal to zero. According to the analysis results, the null hypothesis is rejected at 1% significance level, since the value of the test statistic is 262.4951. In this case, there is a cross section effect in the panel data model. The existence of time effect was also examined, and the test statistic was calculated as 3.981432 at 5% significance level. According to this result, the null hypothesis cannot be rejected at the 1% significance level with no time effects.
\n
Score test, Breusch-Pagan Lagrange Multiplier test, and Hausman tests were applied to identify the suitable model in the study. It was determined whether the analysis should be done with the pooled model, the random effects model, or the fixed effects model. Both the score test and the Breusch-Pagan Lagrange Multiplier test analyze the pooled model against the random effects model. The null hypothesis suggests that the pooled model is appropriate, and that there is no random effect that reflects the existence of heterogeneity. Score test statistic was calculated as 8586.81 at 1% significance level, and the Breusch-Pagan Lagrange Multiplier test statistic was also estimated as 479.82 at 1% significance level. The null hypothesis is rejected relative to the 1% significance level. According to both tests, it is determined that the pooled model is not a suitable model. After it is defined that the pooled model is not suitable, it will be determined whether the model is a fixed effect model or a random effects model with the Hausman test. The test results are given in \nTable 4\n.
\n
\n
\n
\n
\n
\n
\n\n
\n
\n
Coefficients
\n
\n
\n
(b)
\n
(B)
\n
(b-B)
\n
Sqrt(diag(V_b-V_B))
\n
\n
\n
fe
\n
re
\n
Difference
\n
S.E.
\n
\n\n\n
\n
PDP
\n
−0.0004057
\n
−0.0003602
\n
−0.0000455
\n
0.000034
\n
\n
\n
ICP
\n
0.000696
\n
0.0005636
\n
0.0001324
\n
0.0000612
\n
\n
\n
CCC
\n
−0.0004332
\n
−0.0003739
\n
−0.0000593
\n
0.000036
\n
\n
\n
SG
\n
0.0847359
\n
0.0862303
\n
−0.0014943
\n
\n
\n
\n
FDSD
\n
−0.0595096
\n
−0.0650816
\n
0.005572
\n
0.0042299
\n
\n
\n
FATA
\n
−0.2220324
\n
−0.1595819
\n
−0.0624505
\n
0.0142161
\n
\n\n
Table 4.
Hausman test results.
b = consistent under Ho and Ha, B = inconsistent under Ha, efficient under Ho, Ho: difference in coefficients not systematic.
chi2(6) = (b-B)’[(V_b-V_B)^(−1)](b-B) = 25.46.
Prob > chi2 = 0.0003.
\n
Because the Hausman test statistic was calculated as 25.46, the null hypothesis is rejected at 1% significance level. Hausman test shows that the model is a fixed effect model. The fixed effects panel data model results are given in \nTable 5\n.
Modified Wald test for groupwise heteroskedasticity: 918.72 (prob. = 0.000).
Modified Bhargava et al. Durbin-Watson = 1.3899562.
Baltagi-Wu LBI = 1.7238703.
Pesaran test of cross sectional independence = 6.814 (prob. = 0.000).
\n
The findings in \nTable 5\n show that all predicted parameters and model are significant at 1% significance level. Modified Wald test was applied to examine heteroskedasticity in the model. The null hypothesis for the modified Wald test is constructed as:
The null hypothesis is rejected according to the test result at 1% significance level. There is a heteroskedasticity problem in the model. Autocorrelation was investigated with modified Bhargava et al., Durbin-Watson, and Baltagi-Wu LBI tests. The test result is assessed by comparing it with two values which indicate no autocorrelation. Since test statistics are smaller than 2, it can be said that it is autocorrelation. Pesaran test was performed to examine the cross-sectional dependence in the model. The null hypothesis of no cross-sectional dependent is rejected at 1% significance level. For this reason, resistance fixed effect panel data model results were obtained by using in [37] estimator, which provided consistent estimates in the case of heteroskedasticity, autocorrelation, and cross-sectional dependent [35].
\n
When the resistive fixed effects model presented in \nTable 6\n is examined, it is seen that the coefficients do not change, but t statistics and confidence intervals calculated by using Driscoll and Kraay standard errors change. These estimates give consistent results in the case of heteroskedasticity, autocorrelation, and cross-sectional dependent.
According to the estimation results presented in \nTable 6\n, it was found that PDP, CCC, FDSD, and FATA have a negative effect on ROA. An increase of one-unit in PDP, CCC, FDSD, and FATA would induce a decrease of 0.0004057, 0.0004332, 0.0595096, and 0.2220324 on ROA, respectively. On the other hand, ICP and SG have a positive effect on the ROA. An increase of one-unit in ICP and SG would induce an increase of 0.000696 and 0.0847359 on ROA, respectively.
\n
Although the studies in the literature are different in the way of both the country and the sector, similar results were obtained with other studies in the literature that a negative relationship exists between CCC which measures the efficiency of WCM, PDP, and ROA [6, 8, 22, 23, 29, 34]. Besides, the finding of this study is similar to in Ref. [27, 28] who report a positive relationship between ICP and ROA.
\n
\n
\n
6. Conclusion
\n
In emerging countries like Turkey, the development of the industrial sector plays a key role in the development of the country’s economy. Firms in this sector need to solve the financing problem, which is one of the most important problems to survive in markets based on competition. Industrial firms need to become greater in their profitability by effectively managing their working capital in order to reduce the need for external financing due to scarce resources. In this context, this study aims to reveal the tradeoff between WCC and firm’s profitability by using the data of the firms listed on BIST Industry Index in Turkey.
\n
In the study, panel regression analysis was used to investigate the tradeoff between WCC and the profitability of the 41 firms listed on BIST Industrial Index. Dependent variable is defined as ROA; independent variables are CCC, ICP, and PDP; and control variables are SG, FDSD, and FATA. For the model estimation in the study, it was determined that the model had a cross section effect by performing the LR test. The Hausman test defined that the fixed effects panel data model should be applied for analysis. In the fixed effect model, the coefficients and the model were determined to be statistically significant at the 1% significance level.
\n
The results of the study show the existence of a meaningful relationship between firms’ profitability and WCC. In the industrial firms in the study, the decrease in CCC contributed to the increase of ROA. While the other variables remain constant, the increase in ICP raises the firm’s profitability. This situation may be expressed as the fact that the benefit provided by meeting the customers’ demands on time by keeping stocks is more than the cost of holding stocks. Another consequence of the study is that industrial firms can become greater ROA by reducing the duration of PDP. It can be said that the discounts provided by the suppliers for timely payments may contribute to the firm’s profitability. According to the results of the study, a negative relationship exists between FDSD and FATA variables and ROA, while a positive relationship exists between SG and ROA. While an increase in sales volume of the firms may positively affect ROA, the increase in short-term financial liabilities may raise the financial risk of the firms and decrease the firm’s profitability.
\n
Both the findings obtained in the study and the studies in the literature reveal that there is an impact of WCM on the industrial firm’s profitability in emerging countries such as Turkey. In this context, decreasing the cash return period of the firms will reduce the funds used for the financing of the current assets and contribute to increase their asset profitability. In addition to this, the firms should benefit from discounting by reducing the payables deferral period, which will help increase the firm’s profitability. Besides, industrial firms can contribute to raise the firm’s profitability by increasing Inventory conversion period and sales.
\n
\n\n',keywords:"working capital management, profitability, panel data analysis, emerging countries, Turkey",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/57069.pdf",chapterXML:"https://mts.intechopen.com/source/xml/57069.xml",downloadPdfUrl:"/chapter/pdf-download/57069",previewPdfUrl:"/chapter/pdf-preview/57069",totalDownloads:3510,totalViews:1848,totalCrossrefCites:2,totalDimensionsCites:3,totalAltmetricsMentions:0,impactScore:3,impactScorePercentile:84,impactScoreQuartile:4,hasAltmetrics:0,dateSubmitted:"March 13th 2017",dateReviewed:"September 7th 2017",datePrePublished:"December 20th 2017",datePublished:"January 17th 2018",dateFinished:"October 4th 2017",readingETA:"0",abstract:"This study aims to reveal the tradeoff between working capital components and firm’s profitability by using the data of the firms listed on Borsa Istanbul Industry Index in Turkey. Annual data of 41 firms are used for the period 2005–2016 in the study. The working capital components and firm’s profitability tradeoff was examined via the fixed effects panel regression model. Dependent variable is defined as return on assets; independent variables are cash conversion cycle, inventory conversion period, and payables deferral period; and control variables are sales growth, the ratio of short-term financial debts to short-term debts, and the ratio of fixed assets to total assets. Findings show the existence of tradeoff working capital management profitability. A negative relationship exists between return on assets and payables deferral period, cash conversion cycle, the ratio of short-term financial debts to short-term debts, and the ratio of fixed assets to total assets while return on assets is positively related to inventory conversion period and sales growth.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/57069",risUrl:"/chapter/ris/57069",book:{id:"6051",slug:"financial-management-from-an-emerging-market-perspective"},signatures:"Samet Evci and Nazan Şak",authors:[{id:"206626",title:"Ph.D.",name:"Samet",middleName:null,surname:"Evci",fullName:"Samet Evci",slug:"samet-evci",email:"sametevci@osmaniye.edu.tr",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"Osmaniye Korkut Ata University",institutionURL:null,country:{name:"Turkey"}}},{id:"207280",title:"Dr.",name:"Nazan",middleName:null,surname:"Şak",fullName:"Nazan Şak",slug:"nazan-sak",email:"nazansak@osmaniye.edu.tr",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Literature review",level:"1"},{id:"sec_3",title:"3. Methodology",level:"1"},{id:"sec_4",title:"4. Data and variables",level:"1"},{id:"sec_5",title:"5. Empirical results",level:"1"},{id:"sec_6",title:"6. Conclusion",level:"1"}],chapterReferences:[{id:"B1",body:'\nRaynard P, Forstater M. Implications for Small and Medium Enterprises in Developing Countries. United Nations Industrial Development Organization; 2002. p. 1-90\n'},{id:"B2",body:'\nThe World Bank. World Development Indicators: Structure of Output [Internet]. Available from: http://wdi.worldbank.org/table/4.2# [Accessed: 2017–07-01]\n'},{id:"B3",body:'\nTürkiye sanayisine sektörel bakış. Tusiad Basın Bülteni. 2008;08(47):1-8\n'},{id:"B4",body:'\nSanayi Üretim Endeksi ve İmalat Sanayi Değerlendirme Raporu. Bilim, Sanayi ve Teknoloji Bakanlığı. 2017:1-4\n'},{id:"B5",body:'\nPandey S, Jaiswal VK. Effectiveness on profitability: Working capital management. SCMS Journal of Indian Management. 2011;January–March:73-80\n'},{id:"B6",body:'\nKandpal V. An analysis of working capital management in select construction companies. Journal of Commerce & Management Thought. 2015;6(1):7-31. DOI: 10.5958/0976-478x.2015.00001.4\n'},{id:"B7",body:'\nMasocha R, Dzomonda O.The mediating role of effective working capital management on the growth prospects of small and medium enterprises in Polokwane municipality. In: SAAPAM Limpopo Chapter 5th Annual Conference; 2016. p. 157-165\n'},{id:"B8",body:'\nAfande FO. Relationship between working capital management and profitability of cement companies in Kenya. Research Journal of Finance and Accounting. 2015;6(7):154-182\n'},{id:"B9",body:'\nDeloof M. Does working capital management affect profitability of Belgian firms. Journal of Business Finance and Accounting. 2003;30(3):573-587\n'},{id:"B10",body:'\nBlinder AS, Mancini LJ. The resurgence of inventory research: What have we. The Journal of Economic Survey. 1991;5:291-328\n'},{id:"B11",body:'\nSingh JP, Pandey S. Impact of working capital management in the profitability of Hindalco Industries Limited. The Icfai University. Journal of Financial Economics. 2008;6(4):62-73\n'},{id:"B12",body:'\nShin H, Soenen L. Efficiency of working captial management and corporate profitability. Financial Practice and Education. 1998;Fall/Winter:37-45\n'},{id:"B13",body:'\nKeown AJ, Martin JD, Petty JW. Foundations of Finance: The Logic and Practice of Financial Management. 9th ed. Pearson Education Limited: England; 2017\n'},{id:"B14",body:'\nBanos-Caballero S, Garcia-Teruel PJ. How does working capital management affect the profitability of Spanish SMEs. Small Business Economics. 2012;39:17-529. DOI: 10.1007/s11187-011-9317-8\n'},{id:"B15",body:'\nNazir MS, Afza T. A panel data analysis of working capital management policies. IBA Business Review. 2009;4(1):143-157\n'},{id:"B16",body:'\nThapa PDP. How does profitability get affected by working capital management in food and beverages industry. Journal of Advanced Research in Management. 2013;2(8):2-4. DOI: http://dx.doi.org/10.14505/jarm.v4.2(8).01\n\n'},{id:"B17",body:'\nGrass M. Control of Working Capital. Essex: Grower Press Limited; 1972\n'},{id:"B18",body:'\nSmith K. Profitability versus liquidity trade off in working capital management. In: Smith KK, Paul S, editors. Reading on the Management of Working Capital. West Publishing Company; 1980. p. 549-562\n'},{id:"B19",body:'\nToroman C, Sönmez AR. Çalışma sermayesi ve karlılık arasındaki ilişki: Perakende ticaret sektörü üzerine bir uygulama. Erzincan Üniversitesi Sosyal Bilimler Enstitüsü Dergisi. 2015;8(1):15-24\n'},{id:"B20",body:'\nDursun A, Ayrıçay Y. Çalışma sermayesi-karlılık ilişkisinin IMKB örneğinde 1996-2005 dönemi analizi. Atatürk Üniversitesi İktisadi ve İdari Bilimler Dergisi. 2012;26(3):199-214\n'},{id:"B21",body:'\nÖz Y, Güngör B. Çalışma sermayesi yönetiminin firma kârlılığı üzerine etkisi: Imalat sektörüne yönelik panel veri analizi. Sosyal Bilimler Enstitüsü Dergisi. 2007;10(2)\n'},{id:"B22",body:'\nQuayyum ST. Relationship between working capital management and profitability. International Journal of Business and Management. 2012;7(1):58-69. DOI: 10.5539/ijbm.v7n1p58\n'},{id:"B23",body:'\nAzeez OT, Abubakar MA, Olamide FT. Analysis of the effects of working capital management on profitability of listed Nigerian conglomerate companies. FWU Journal of School Sciences. 2016;10(1)\n'},{id:"B24",body:'\nShahzad F, Fareed Z, Zulfiqar B. Impact of working capital management on firm’s profitability:A case study of cement industry of Pakistan. European Researcher. 2015;91(2):86-93. DOI: 10.13187/er.2015.91.86\n'},{id:"B25",body:'\nChing HY, Novazzi A, Gerab F. Relationship between working capital management and profitability in Brazilian listed companies. Journal of Global Business and Economics. 2011;3(1):1-14\n'},{id:"B26",body:'\nPandey NS, Sabamaithily S. Working capital management on profitability: Cement industry in India. SCMS Journal of Indian Management. 2016;April–June:81-95\n'},{id:"B27",body:'\nMuhammad M, Jan WU, Ullah K. Working capital management and profitability: An analysis of firms of textile industry of Pakistan. Journal of Managerial Sciences. 2012;6(2):155-165\n'},{id:"B28",body:'\nArunkumar ON, Radharamanan T. Analysis of effects of working capital management on corporate profitability of Indian manufacturing firms. International Journal of Business Insights & Transformation. 2011;5(1):71-77\n'},{id:"B29",body:'\nAksoy EE. İşletme sermayesi yönetimi ile firma performansı ilişkisi: 2008 krizi örneği. Finans Politik & Ekonomik Yorumlar. 2013;50(586):9-21\n'},{id:"B30",body:'\nGreene WH. Econometrics Analysis. 5th ed. New Jersey: Prentice Hall International; 2002\n'},{id:"B31",body:'\nBaltagi B. Econometric Analysis of Panel Data. 3rd ed. USA: John Wiley & Sons Ltd; 2005\n'},{id:"B32",body:'\nHausman JA. Specification tests in econometrics. Econometrica. 1978;46:1251-1271\n'},{id:"B33",body:'\nBrigham EF, Ehrhardt MC. Financial Management: Theory and Practice. 14th ed. USA: South-Western; 2014\n'},{id:"B34",body:'\nKeskin R, Gökalp F. Çalışma sermaye yönetiminin firma karlılığı üzerine etkisi: panel veri analizi. Doğuş Üniversitesi Dergisi. 2016;17(1):5-25\n'},{id:"B35",body:'\nTatoğlu FY. Panel Veri Ekonometrisi. 2nd ed. İstanbul: Beta Yayınları; 2013\n'},{id:"B36",body:'\nUkaegbu B. The significance of working capital management in determining firm profitability: Evidence from developing economies in Africa. Research in International Business and Finance. 2014;31:1-16\n'},{id:"B37",body:'\nDriscoll JC, Kraay AC. Consistent covariance matrix estimation with spatially dependent panel. Review of Economics and Statistics. 1998;80:549-560\n'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Samet Evci",address:"sametevci@osmaniye.edu.tr",affiliation:'
Osmaniye Korkut Ata University, Faculty of Economics and Administrative Sciences, Osmaniye, Turkey
Osmaniye Korkut Ata University, Faculty of Economics and Administrative Sciences, Osmaniye, Turkey
'}],corrections:null},book:{id:"6051",type:"book",title:"Financial Management from an Emerging Market Perspective",subtitle:null,fullTitle:"Financial Management from an Emerging Market Perspective",slug:"financial-management-from-an-emerging-market-perspective",publishedDate:"January 17th 2018",bookSignature:"Guray Kucukkocaoglu and Soner Gokten",coverURL:"https://cdn.intechopen.com/books/images_new/6051.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:"978-953-51-3737-5",printIsbn:"978-953-51-3736-8",pdfIsbn:"978-953-51-4019-1",reviewType:"peer-reviewed",numberOfWosCitations:9,isAvailableForWebshopOrdering:!0,editors:[{id:"70354",title:"Ph.D.",name:"Soner",middleName:null,surname:"Gokten",slug:"soner-gokten",fullName:"Soner Gokten"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:{id:"205587",title:"Dr.",name:"Guray",middleName:null,surname:"Kucukkocaoglu",slug:"guray-kucukkocaoglu",fullName:"Guray 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1. Introduction
The extension and transferability of what has come to be known as PC [1, 2] has become stalled in some countries [3]. Many believe it to be a consequence of inadequate funding or even political indifference [4]; others question whether it might be due to lack of conceptual intelligibility and transferability across languages and call for a fresh PC [5, 6] definition that incorporates its philosophy and ethos while being fully transferable across countries and cultures.
But what can be said to constitute, identify and define the Palliative Care Ethos? With the patient at its centre, PC looks for direction in their own and their loved ones’ narratives:
‘You can tell them all that it was all right’, was the unpretentious and comforting message Cicely Saunders was asked to pass on to a lady’s relatives once she had died. It was important for that patient to let her loved ones know that she had not gone through a strange, dramatic, or just unlucky experience, (…) written up as such without sentimentality or sensationalism, but a common experience ordinary people have always faced, writes D. Clark [7]. A good example of the rich exchanges full of meaning and depth that can take place within the ordinary delivery of PC. So beautifully common in many ways; and yet, so elusive to capture in a defining snapshot to apprehend its uniqueness.
‘The joy, purpose and meaning of medicine has been codified, sterilized, protocolised, industrialized and regimented’ says Dr. Eric Levi [8]: a stark reminder of the reality in ever-advancing health systems which seem to have forgotten the more artistic aspects of medicine which allows compassion to highlight our common humanity, a fundamental aspect of PC.
2. The purpose of medicine
Medicine is as old as humankind itself [9]. At first it was mythological, the causes of diseases were attributed to the gods or spirits, subsequently acquiring a more scientific character as it was recognized that diseases had physical or environmental causes.
Hippocrates has been considered the father of scientific medicine. The Hippocratic Corpus [10], with its 53 books, has philosophical and ethical writings such as the Hippocratic Oath and Aphorisms, as well as others of medical order consisting of 7 books on Epidemics, 4 on the Regime, 4 on Diseases, 2 on Predictions, 2 on Women Diseases, Instruments of reduction of Joints and Fractures. Writings used by doctors to learn for centuries. One of these texts, the Hippocratic Oath, remains valid- It concisely points out the duties of doctors, duties that were not imposed on them by the authority of the moment but rather, somewhat self-imposed after assessing the value and importance of their own work. This Oath is a model of professional behavior not only for doctors but for all professions.
Medicine is finite, limited. People will die. Diseases will change, but it always comprises great respect for human weakness. Sometimes we will have patients with acute problems, sometimes chronic conditions, some patients will be conscious and sometimes unconscious, sometimes it will be curable diseases and sometimes incurable, sometimes we will have friendly patients, sometimes we will have patients with diseases that we like to treat and sometimes with pathologies that for the doctor are unpleasant, but they are all our patients, all expect us to treat them with respect, they want to feel taken care of, they want humanitarian treatment.
Our medicalised modern cultures tend to render reason and mystery mutually exclusive, defining “death by disease” as failure, and dying as disgraceful. Providers and policymakers alike marginalize aging and dying individuals, while formulating largely ineffective strategies to prevent deaths from violence or epidemics, terrorism, and famines. Policies to nurture care and support the elderly, those with long terms conditions and children [11, 12, 13] born with congenital medical conditions, malformations or different capacities, are too often inadequate and departed from reality. They tend to be declarations of intentions lacking in budgetary provision.
3. Palliative care
3.1 Meaning and fullness of worth within the health and social contexts
It is palliative care mission to demonstrate that each life is morally significant to its natural end, restoring patients’ and families’ quality of life where possible, and attending meticulously to the dying period when necessary [3, 4].
PC changes the perspective from which the world sees health and social care, since its philosophy gives standing to the multiplicity of beliefs and communication patterns manifest in the collective of suffering patients. This motivates the articulation of a good enough ethic.
Contemporary literature [3] shows researchers’ acknowledgement of historically relevant milestones in PC roots from bygone days and subsequent evolution, including Palliative Medicine being recognized in some countries as a specialized field of training and work. There is also explicit acknowledgment of the difficulties affecting uniform implementation of its philosophy and principles. Some projects centre future advances and growth in PC provision with promising results in relation to identifying the founding ethos of PC by reproducing its initial way of showing the depth of society’s concern for its more vulnerable members, based on its values when alleviating the suffering experienced while facing aging, disease, life threatening pathologies, dying and death.
Such ventures highlight the importance of setting the scene for possible advances to integrate ethical, legal and social implications in years to come to benefit the many likely to need it. It likens the development of the field to a journey; one that sets off on the knowledge the fullness of meaning and richness of PC can only be approached by taking its long view.
A sound understanding of PC foundational bases [2, 14] facilitates answers to many questions needing an answer, although some voices of those who seek a more bio-physical-psychological palliative care model strongly disagree. It is, for example, motivating to take into account the different creative initiatives born in clinical settings in the context of the COVID-19 pandemic; it confirms how man continues to look for ways to alleviate suffering in the most challenging situations making use of what they have to hand. In our time, the inventiveness brought to the bedside of the dying has been astonishing, giving hope to those of us who want to offer holistic care to those who see their lives threatened, including aging and the natural end of life, by some entity threatened life expectancy.
This chapter will aim to identify what constitutes the enduring ethos of PC as it continues to evolve and grow beyond the walls of St Christopher’s Hospice, flagship of Cicely Saunders’s endeavor to comfort the dying by letting them know that they matter because they are who they are; and they will matter to us until their last moment of their lives.
3.2 Modern hospice movement evolution
Looking into what is understood by this vocable takes us along surprising trails as a Work of Mercy, with deep ancestral Judeo-Christian roots [2]. It is depicted well in both the Old and the New Testaments, for example, in the Parable of the Good Samaritan and many conceivable and incomprehensible healings. It can be followed in the labour of hospital religious orders over the centuries which persists to this day in initiatives such as the contemporary Pastoral of Health. It is doubtlessly, care that has historically been largely provided by Christian orders that hold to the divine ‘Thou shall not kill’, and are moved to love and compassion.
In our time, proud of its origins, it is a formalized and widely recognized as a growing medical field which has its foundational modern roots in (Dame) Cecily Saunders’s concern and work to remedy the poor medical care being provided to dying hospital patients. Over time, its medicine had shifted [15] the focus away from the needs of those who could no longer benefit from evolving technology and life-saving treatments. But it did not stop there as the medical world continue in its way to ignore those dying in its institutions.
Cicely Saunders, established unambiguous foundations for the Modern Hospice Movement [2], one of which is to be found in the togetherness of Head (mind) and Heart (compassion and our own vulnerability) when caring for these people. It was not, she explained, an idea that occurred to her, but rather the mandate received from David. David Tasma, a Polish Jew, mortally ill with pancreatic cancer, when, broken by the profound suffering he was experiencing, as he was facing his own mortality so far away from his own country and those he knew and loved well asked her:
“Can you say something to comfort me?” taking Cicely Saunders away from doing something to him, or giving him some medication to soothe his distress. A little later, he added “I only want what is in your mind and in your heart.”
The Modern Hospice Movement, generally known as Palliative Care outside Great Britain, was thus born to use scientific rigor to research and treat symptoms such as pain. Its focus on the holistic needs of patients: physical, emotional, social and spiritual, without forgetting the professional dimension. Palliative Medicine is the only medical specialty that recognizes care of the spiritual person as part of its mandate [16]. Its science and care are applicable to any person with an incurable, complex or life-limiting illness; its principles can be applied to that person’s care from the time of diagnosis. This means good symptom management plus supportive and holistic care occurring alongside: it may be provided by any health care clinician, using the same principles to provide a ‘Palliative Approach’ to medical and nursing care.
Palliative is derived from the Latin word ‘pallium’ meaning to cloak someone who is ill, sick, lonely or needing protection. Symptoms are eased even if the underlying condition be cured.
Maximizing wellbeing and nurturing the hope to maintain or improve perceived quality of life can be achieved in a variety of ways, however, it is imperative to guide all interventions by a common moral compass which indicate the manner by which teams allows someone to be themselves at what can be an extremely difficult time in their lives. PC strives to acknowledge the person as a whole - addressing snags affecting different aspects of their life. A multi-disciplinary approach supported by the skills of different professionals, pooled and utilized as necessary.
Hospices and Palliative Care Units alike house an ethos of care which should extend beyond their walls to places where symptoms need to be eased, the underlying condition not amenable to be cured [14].
3.3 Limits of action: caring, not killing
PC acknowledges the reality of death and seeks to assist patients and those around them to accept its inevitability accepting dying as a normal part of life, teaching that helping people to die well, i.e. “in peace”. Nor should it be confused with actively helping people to die, i.e. to bring their deaths about.
Its distinction with euthanasia is at times obscured by claiming that the outcome (death) is the same for both and that the intention of both is to relieve suffering. These assertions are true, as far as they go, but there is a moral distinction between giving a “lethal injection” and the interventions that constitute palliative care. These interventions include the provision of symptoms relief by titrating medication against the symptoms. The aim being to achieve the best control of symptoms with the least side-effects, for which different medications are available: if one medication does not suit, there are usually others to try. Giving the right medication for each symptom at the lowest dose necessary to alleviate the symptom.
Sometimes, there might well be situations where relief of very difficult symptoms, such as pain that does not respond to analgesics and adjuvants or intractable shortness of breath and a number of catastrophic clinical events such as some hemorrhages or pulmonary embolism, can only be achieved by medication doses that result in deep sedation.
The clinical situation might be extremely complex leading to a binary status quo in which the options are either vigil and in unbearable anguish or unconscious and calm. In this scenario, the alternatives are either dying with intolerable suffering while being aware of it or dying comfortably while unconscious. There is no real choice here – the only morally good course is to address the patient’s symptoms accepting the side effect of sedation that inevitably accompanies this. The Lex Artis requires that all intervention is proportionate and relief of symptoms and suffering sought at all times by proportionate means, and regular reviews.
A frequently held fear or misapprehension when working to control symptoms is that the therapeutic maneuvers used in the process might be also shortening life and hastening death. Medication used need to be clearly explained regarding its purpose, effects and side effects; morphine is regarded with particular fear and suspicion. However, in most situations its careful titration following best practice guidelines under specialist’s advice will alleviate symptoms with no noticeable shortening of life. On the contrary, we should not underestimate the potentially life-shortening effect caused by the stress, and distress, of severe uncontrolled symptoms. This is an area in which good Palliative Care is able to help.
PC is certainly able to deliver sound, scientific based care with the vulnerable friendship of the heart. Not many could openly object to these foundations. Yet, many committed practitioners ignore them in their daily practice. Could there be a different reason behind? Or, could it be due to a lack of proper understanding of its place in science, health and social care?
Approaching Palliative Care from the point of view of its conceptual basis opens a fascinating quandary for the studious physician when the need to clarify to others, patients, family, cares, health and social professionals, society in general, what PC is and what is not, presents itself. It takes time and effort to work through it all when helping someone accept our help in a timely fashion. Communicating it in a conceptual nugget what PC is a complex task.
There are definitions put forward by organizations such as WHO and IAHPC. And there are also well defended theses, such as Randall’s, to deconstruct and determine how such definitions are rather aspirational “declarations of intention”.
WHO’s [17, 18] definition includes quality of life in their declaration of intentions. Unquestionably, a very important aspect of the palliative philosophy is its commitment to taking care of well-being by excellent symptom control to help maintain the quality of that life for as long as it such. For many, however, life -in its sanctity- cannot be classified and protected in direct relation to its perceived quality at a given time.
While life itself is an objective good, necessary to enjoy many others, its quality or lack of it, is a subjective good, dependent on many factors. For example, for many, happiness is essential to life and it is the pursuit of that happiness that gives meaning to life. It is particularly suggestive to understand the quality of life perceived by those who have learned to live life through the small, insensitive things that adorn it. While others think that the “core” of life can only make a concrete sense among those who believe in the Transcendent, be it God or not.
Dr. Pettus [19], a political sociologist claims that our modern and medicalized cultures make reason and mystery mutually exclusive, defining death from illness as a failure, and dying as shameful. Suppliers and legislators similarly marginalize older citizens and the dying, while formulating ineffective strategies largely to prevent deaths from violence or epidemics, terrorism or famine. The goal of PC is to support those with an incurable disease so that they can live the rest of their lives as well, and with as much sense as possible, giving them the necessary support when, eventually, they reach the natural end of their lives, and die from their illness.
Painful and distressing deaths without palliative care or relief from physical pain, in remote areas, attract neither political attention nor budgets, says Pettus. A growing effort is being made to establish and advance Palliative Care’s contextualized advocacy around the world, based on its own “ethos” and spirituality that ensures its implementation and availability for many.
Those who work advocating PC believe that, to be faithful, the its safeguarding should reflect the “ethos” of the hospice movement. This is a central concern for many, particularly concerned to understand how such ethos could be established and how it could dissipate into loss, disappearing. It is worth knowing the work done by those who care about those intangible aspects of the hospice movement that precisely make it so. A particular apprehension is the one that asks how the “ethos” could be lost by spreading more widely t is marketed while losing its well-founded and carefully established training its approach to transmitting its philosophy and principles.
Cicely Saunders left a great number of written documents. This one is particularly representative of her work:
“The longer I work with the dying and their families, the more I learn about life and the small things that are so important to each one of us. Dying is never easy, it is done differently by each person. Fear of the unknown is what most of us can identify with. Having a terminal illness including diseases of cancer, MND and other neurological illnesses, Dementia will take us all, whether patient or a loved one, to places in our lives we would rather avoid and will often include fear of unknowns. How we often support our patients & families is to get alongside them as best we can and share some of our skills and experience to break down these fears. We don’t always get things right because dying is not an exact science. What I think is also true is, yes, we put ourselves forward as a resource for the community, to show leadership in this field, but we can’t do this on our own” [16]. She was not a theorist and understood others´ suffering and distress and led the way to alleviate their suffering, advocating for a more comfortable dying process and a more acceptable memory of it to their loved ones who live on.
Nobody should be expected nor forced to consent to all life-prolonging treatment; Palliative Care does not preclude receiving life-prolonging treatment and, delivered alongside those treatments and interventions can be really productive. Each person should be able to choose for themselves how much treatment they are willing to tolerate for limited gains in life expectancy, and to refuse treatment they do not wish to receive. There is, however, a responsibility to use this life well in service to the end (and to reach one’ full potential).
The challenge is perhaps discerning when is it time to let go of this life, and so it has been since humans inhabit the earth. St. Paul’s illustrates this tension well in his letter to the Philippians (1:21–24).
Each individual will expect their remaining life to allow them to be and do what their very own idiosyncrasies such as age, illness or responsibilities to others requires to complete their lives. Often, we meet people who may feel that their life is approaching its natural end and are ready to relinquish this world when their time comes. Nowadays, PC has evolved to offer other services under the name Supportive Care [20, 21] based on patient’s needs, increasingly used in the acute sector and well accepted by both patients and professionals in the context of potentially curative or life sustain treatments which, nevertheless, can be onerous to receive and follow. To many, the adjective Supportive is better accepted and understood than Palliative.
It is important to find a common base which help recognize PC under whatever wrapping it might come in. Much confusion has come from the different, often random translations of the vocable hospitium [22] which has come to be understood different things in different languages. Hospices, as understood from its Anglo-Saxon use, are far more than mere buildings; they house a philosophy of human relationship and hosting which could be considered as direct descendants of the medieval form because behind their assertive philosophy sits a highly personal holistic approach which places the physical, emotional and spiritual welfare of patients and their families at its heart.
Still, many still identify them with places where patients go when there is nothing more to be done, where people go to die. The problem with this, is that much of the suffering that could be alleviated in the right space, is not, because it is left too late, thinking they are places one might go to die.
Much work is nowadays undertaken to facilitate the understanding of terminology in our field, many researchers look and write about palliative care. In Spain where it has been translated as `Cuidados Paliativos`, thus stressing its most physically relevant aspects of care. Research groups such as ATLANTES. Instituto Cultura y Sociedad. Universidad de Navarra look for its secret, which they call “The Intangible “.
Our own research to define the ethos of PC moves in the same lines, recalling The Little Prince affirmation “And now here is my secret, a very simple secret: It is only with the heart that one can see rightly; what is essential is invisible to the eye.” [23], which links seamlessly with the thoughts of those pioneers whose legacy is now ours to work with and transmit forward “All those intangible values are expressed in concrete actions able to transmit unconditional acceptance and the affirmation of the patient’s worth as a person [24].
3.4 Scientific aspects
Having set its humanistic aspects, it is imperative to look for PC scientific bearings.
Much has been written and researched around “the scientific” and the Ethos of Science, which refers to the “toned affective complex of values and norms that is carried out to be binding on the man of science. Rules are expressed in form of instructions, prescriptions, preferences and licences” [25].
It is acknowledged that the end of all science is the extension of agreed knowledge and that it must be able to be explained through its technical methods: “empirically confirmed and logically coherent statements of regularities (these are often predictions)” [26].
PC has a strong humanistic element but it is also science [25, 27]. Predictions are even more important in this field, where informed assumptions are regularly made to underpin decision-making as it is also science and, as such, it must be governed by laws ordering any other science. This issue, together with poor conceptualization, could have contributed to the deficient PC extension [28] and expansion; the fact that some have arrogated themselves the right to choose what aspects of the palliative philosophy and principles to apply, choosing them at convenience, either out of ignorance or neglect might have arrested its expansion.
3.4.1 The science and its philosophy
Cicely Saunders is known to have been a woman of multiple interests which she followed by training to be a nurse, almoner and a doctor. She had other interests such a full understanding of Christianism, Philosophy and is considered to be a humanist. She liked to read and study the different aspects of things in depth, often citing authors and philosophers such as Francis Bacon. Philosophy as science certainly underpins the philosophy of the Hospice Movement. Understanding this, together with the great value she gave to the scientific foundations of palliation brings us to consider the Philosophy of science as necessary.
Science is a limited human activity that has its origin in man’s observation of ordinary experiences and his desire to know the truth. In its output, science provides proven knowledge that goes beyond human experience. Its classic ideal seeks to achieve true knowledge based on reason, compatible with that which is provisional and reviewable.
Classical sciences such as philosophy, theology or mathematics share some features with many modern experimental sciences such as physics, biology or neuroscience. However, the notion of science is often applied almost exclusively to experimental sciences.
A broader perspective applies the concept of science in an analogue way. For example, experimental sciences and common philosophy both seek a knowledge that extends beyond ordinary experience; the difference is that the philosophical approach does not willingly exclude anything that can be rationally studied. Experimental sciences self-limit the search for empirical evidence using specific principles of reasoning.
The same reality, for example, the suffering of the human being is the subject of study of different disciplines (biology, sociology, sociology, psychology, medicine, which means that each science has its own objectives, methods and therefore, also, results. A situation which has leads to the fragmentation of knowledge which clouds the understanding of the discipline.
The philosophy of science is a philosophical reflection that seeks to understand the nature and value of science, given that philosophical reflection on scientific activity is carried out from reason. Logic, history, sociology… but, especially from a meta-scientific perspective, experimental science is a clear test of human ability to transcend what is immediately given to observe by the senses.
Philosophy, as science has evolved in time. Among the current main current currents in the philosophy of science, Thomas S Kuhn’s historical ‘sociological’ approach states that the paradigm shift is not due to logical reasoning but to a process of conversion of scientists.
Science needs to be communicated. Scientific communication demands clear conceptualization. Each concept has a meaning and a reference that does not have to be unique. Thus, terms can refer to many semantic fields (evolution of pain, evolution of human suffering) and encompass in their meaning various mechanisms related to their perception by society at that point in history.
But there is more as concepts, these most elementary scientific constructions can be either qualitative or quantitative.
Quantitative concepts are common in healthcare and have a mathematic expression, (temperature, blood pressure…) and are called magnitudes. They are associated with methods and measuring instruments, acting as bridges between theory and experimentation, because they make rigorous data processing as possible. These concepts, common to physical aspects of medicine are well used and known: they have extended to less measurable concepts such as physical pain by a number of conceptual models.
Concepts are not static. The understanding of the atom, today is much greater than a few years ago.
Science uses models to simplify reality, idealizing some of its aspects. Some models are schematic representations of what you want to study, while others are much more complex idealizations. PC is defined by many as a phenomenon and as such, for its realization the scientist needs to use informed guess (very common in PC advanced communication) to tease out what properties of phenomena form the appropriate basis for idealization and What features can be ignored.
To achieve which, the role of creativity and interpretation are essential, as is scientific induction, including inference.
For example, about could have been causing the back pain a patent suffers from. Or the reconstruction of a family distress from our knowledge of a patient’s disease trajectory. Or extrapolation when a new cluster of symptoms appears in relation to biochemistry analysis results taken a few days before of an election from surveys.
A situation which tries to help complexity using models: The model is a scientific construct between theory and reality. On the one hand, it concretes the theory and on the other it simplifies reality.
Scientific statements, are a very varied type of scientific construction. They range from expressing the data obtained to an experimental measure: “You have cancer causing you pain several times in 24 hours as the analgesic effect wears off”. Up until a law is formulated: “Patients with cancer who have continuous pain shouldn’t have to earn their analgesia; opiates should be given regularly” stated C Saunders. Like models or concepts, they are not an exact translation of what is going on in nature. The statements and laws that are constructed from them are, by definition, approximate, provisional and contextual, because in the future the concepts can be further specified and the measuring instruments can be improved.
Theoretical Systems arise from statements and laws that articulate and command each other. Well formulated, they become consistent and are susceptible to improvement, at the same time, they remain always open, i.e. they are not closed systems: at least they have initial conditions and contour conditions. They are formulated in a fragmentary way, just as a child acquires greater ease in the management of a language.
Science and scientific proceedings therefore, come supported by complex structures that need understanding and respect. Many work to help others understand these and give us principles to promote respect, setting out the Ethics of Science, worth of a chapter to itself.
Sociologist Robert Merton [29] identifies four institutional imperatives—universalism, collectivism, selflessness, and organized skepticism—such as the ethos of modern science—its “fundamental values.” Mertonian laws cover aspects such as: volume of research funds, consistency of the professional network, community collectivism and involvement in non-academic content.
Universalism. Promotes the value of scientific claims for what they bring to society and not by who brings them to the scientific arena or even which personal or scientific background they bring their claims from. Merton recognizes and warns about the power of society at large and a scientific private cosmos which may clash with universalism. “Ethnocentrism is not compatible with universalism,” he affirms and requires that “careers be open to talent,” because science must be a meritocracy. Therefore, to hinder science ability to nurture knowledge, by excluding capable people from developing their scientific callings on the basis of competence, harms scientific progress at large.
This aspect could be detrimental to PC, where the friendship of the heart constitutes one of two foundational cornerstones, without which, extreme over technification and medicalization might overrepresent its science. PC demands more impalpable aspects to achieve its mission and the vast volunteering that support it is testimony of the founder’s vision to successfully combine both knowledge and compassionate doing.
Data and theories are valuable assets, continues Merton, which can be cond in models or scientific structures, even named after the scientist behind it when thought to constitute a significant contribution to the field and brings prestige to the so-named person or research group. Such prestige is in itself an honor best respected by those who work in that field, hence the reason why communication of scientific results is prized by science which despises secrecy about them.
He [29] states that Universalism is also a democratic principle (laissez-faire), “impersonal criteria of realization and non-fixation of status characterize open democratic society”. established scientific knowledge should be accessible to all members of the scientific community to use, explore, etc.
Collectivism, also communism, does not refer to the Marxist-Leninist movement, but to the view that scientific knowledge is a resource to be shared with the entire scientific tribe, regardless of which individual scientists in particular have produced a particular discovery.
One of the things a scientist has to do to meet this standard is to communicate his findings to other scientists. Knowledge that is not made public does not help the scientific community.
Interestingly, Cicely Saunders took good care to encourage collectivism of the scientific ethos [30] of the new field of medicine was set to become. Palliative Care was born with no scientific secrets as she sought to tell others what she had found to help the dying from the very beginning when every Saturday morning the met to “work and pray fror Hospice”.
Disinterest, maintains that scientific accounts ought not to be personal in their outlook and, rather than empower the individual scientist own plan, they should bring a greater good to a bigger group. Merton [29] argues that disinterest is an institutional obligation, not be disarrayed by individual motives. Individuals should certainly have personal motivators such as scientific awareness, publications, recognition, curiosity, among others. Such desires are licit as far as that will encourage them to work with others to obtain the results that will made the group shine.
“Institutional control of a wide range of these motivations” better characterizes what is fundamental to science and helps avoid science scam. Merton [29] believes this is reinforced by the rigorous monitoring that scientist undergo at the hands of other scientists. Interestingly, he also highlights the connexion researchers establish with their customers different from those other professions. Alarmingly, when lay people and scientists establish closer working links, such connection frequently spurs fraud and pseudoscience.
Finally, Organized skepticism, encourage omitting one’s own judgment and using only empirical and logical criteria. This is frequently the strained connection between and those vital areas inclined to offer judgment.
While difficult, it is comforting to discover that the scientific aspect of Palliative Care, “its head” is up to any other scientific effort, although it is true that there would be much to analyze and work in order to give greater rigor. It is especially relevant to strengthen the learning in countries where Palliative Care and Palliative Medicine are not recognized as specialties. This leads to situations in which the expert becomes such by means of an expensive, often online, master degree and short clinical observational stays with experts who are such by the same method, very distant from the structured learning that a four-year specialist training affords the individual.
From its inception Terminal Care, as it was our field originally known, it was ambitious in its founder’s commitment to practice within scientific frameworks, to research and treat symptoms such as pain [2, 30, 31, 32]. The focus being the person as a whole and responding to patients’ physical, emotional, social and spiritual needs. Palliative Medicine, is today a consolidated [33] medical specialty which incorporates the care of the spiritual dimension of the individual as part of its decree although, sadly, not in every country.
On the other hand, most cultures and formalized religions [34, 35] have incorporated palliation to their teachings and fullness in some way, having also “come to join the movement” with their own array of richness which, although not known to many until now, has always being present in any human grouping. It is such an interesting and fascinating aspect that deserves another full chapter to really learn how other communities look after their vulnerable members, the ill, the dying and how to support those who are bereaved.
3.5 Patient centred and directed palliation effort: quality of life
It becomes necessary to position ourselves and acknowledge the conceptual mare magnum which too often blurs and disorders the delivery of timely PC, its scientific structures perhaps too vague to work on.
Probably, the best way to understand the undeniable value of PC is to allow others, those who have experienced PC, rather than deliver it, to inform our effort.
Patients´ narrative recounting their experience is full of details; something we become aware of when we introduce someone, visitor or professional from other specialty, to the dynamic of our consultations. We are talking about its other foundation: “The vulnerable friendship of the heart”.
As with any vital aspect, and Palliative Care is very much about living life to its natural end, we encounter have a static duality - dynamic, negative - positive, pain-pleasure, darkness-light, night day, death - life experience that makes this field one of very strong contrasts.
How many times have both patients and their families told us that they are “living on a real roller-coaster of emotions, experiences, illusions and losses.”?
Hundreds of sick people who tell us about what they experience when the afternoon falls and the day - perhaps their last day - becomes night. Likewise, the desolation of the last sunrise when a new day arrives that they do not know if they will have the strength to face in a dignified way. How much suffering holds the narrative of “I’m afraid of the night in case I die during it. I feel horror at dawn because I am still alive and have to face a new day and I don’t know if I can.”
As professionals, it is in these moments of very personal, intimate exchange and confidence, when we confirm that something very special imprints character to our work. Yes! something that reaches the other. Just as their desolation reached us. For me, the question is “how could we find what that something is?”
Occasionally, it’s rare but extraordinarily motivating, people look us in the eye and ask “And how can you do this every day? Sometimes they tell how they have seen us tend to another patient and have seen the pain in our eyes. They insist “where do you get the strength to come back the next day with a smile? Where does the inspiration come from for your eyes to shine when you approach me, broken my useless body? Me who with my pain caused you pain?” We respond with professionalism, humanism and simplicity. In that therapeutic space, we left something of us. It is very likely that in such a personal exchange, the very spirit of PC is contained.
It would therefore appear that experiencing PC is possible by both: those who need it and those trained to deliver it. As an experience it falls into the phenomenological sphere which incorporate a combination or synthesis of the positive aspects described, experienced in situations of suffering and uncertainty which can be qualified as intensely relational. If these moments pregnant with human intensity are symbolized by a single quality, it would be one very close to life itself and characterized by light, beauty and love gathered in one. A phenomenon that can be experienced but difficult to describe and be identified by the someone else, not actively involved or not adequately trained.
Thus, life to its end can be a wonder in the development of images and s never seen before, thoughts never before thought, realities never dreamed of, constantly emerging, constantly reminding us that the person’s individual universe might not yet have reached the limits of its possibilities.
Palliative Care might well be the force able to bring forward the life that remains as such, as an evolving universe, says R. Bruening, an organic chemistry scientist who says his work is that of anti-cancer drug maker and CEO. Practising good Palliative Care can help whoever receives it to reach their own, yet unrealized, potential as a human being.
These profound understandings come from experience; the problem is that trying to quantify subjective experience is like trying to create a metric for a favorite color. Or flavor of ice cream. Or to measure suffering by the volume of tears cried. It is also possible to use Scientific constructs and models to objectivize the experience.
Indeed, WHO’s definition of Palliative Care, considered by some authors to be mere statement of intentions, incorporates the concept of quality of life since a very important aspect of palliative philosophy is its commitment to well-being, quality of life, as long as it exists. Many consider happiness to be essential to closing a full life, and their pursuit of what gives meaning to life. It is particularly suggestive to have learned to live life through the small, insensitive things that adorn it. Others say that the “essence” of life comes to its full meaning depending on how transcendent.
From a metaphysical (spiritual) point of view the essence, as in any matter of vital nature, and Palliative Care is very much about life and living it, incorporates static-dynamic, negative–positive, pain-welfare, darkness-light, night - day, death -life, soul-body duality, which make this field one of very strong contrasts.
It might be that experiencing the essence of Palliative Care is possible: combination- synthesis- of the positive aspects described, experienced in situations of suffering, uncertainty and very, very relational. If these moments pregnant with human intensity are symbolized by a single quality, it would be a very close to life, the very life characterized by - light, beauty and love – gathered in one and become like One, that could be identified.
The European Consortium in Healthcare Outcomes and Cost–Benefit Research’s extensive study concluded that those theories based on a QALY approach do not give a true account of the manner real populations performance outlines (Quality Adjusted Life Year) is a non-specific measure of disease burden, which tries to encompass value and amount of life lived; used in economic appraisal to weigh the cost of healthcare interventions and their impact on society as a whole. An entirely foreseeable result: we can no more predict what patients will want or need when a given disease takes hold, than guess that their favorite color or the ice cream flavor they disfavor. Such understandings only come when know when we know them and we spend time with them and they tell us themselves. Or we observe their behavior and possessions as well as their loved ones.
Enabling patients to choose what they can has consequently become very relevant and organizations such as “Nothing about me without me” [35] leading the way help bring forward the more humanistic dimension of PC.
Consent laws focus on the ability to understand illness and treatment options, as well as the consequences of treatment selection or refusal. As patients often are not aware of their own goals and values because and they have not specifically paused to think about them or make them explicit, getting to know the patient through asking the right questions and listening carefully to answers which can be new to the person, can help us understand their choices. We learn what is most important to patients in their life right now, and what would their ideal end of life look like. Active listening [35] will afford us the knowledge of their wishes relating to spending time or even dying at home, not wanting to be in bed attached surrounded by machines. We often listen saying little while the patient comes to realize what they want and vocalize some outstanding goals of care. After this, the patient -as the director of a well-rehearsed orchestra and the entire palliative team came up with a plan of care to meet those goals to the greatest extent possible.
Patient choice, as an entity, must become part of the medical Curriculum and take its rightful place as a basic starting point of all good medicine.
Bereavement is not to be forgotten. Frequently, the bereaved come with a card, cake or fruit to let the professionals know they are grateful for the great care provided to their loved one. They do not mention a single common research metric, but the team are motivated by their gratitude in remembering their patient. It is a very humbling experience as we are reminded of the uniqueness of each life and the impact of our common humanity.
4. Chapter motivation and scientific interest
After almost 30 years of combining multilingual medical care in three countries with a special interest in Palliative Care practiced at all levels of care in the country in which it had its modern origin and at the political-organizational level of the country of origin itself, the pressure to address its expansion from different perspectives: conceptual, semantic and semiotic; anthropological, philosophical, political and welfare, of confronting the intrinsic philosophy seeking what imprints character on a multi -professional attention at the international level at a time when there is great confusion as to what constitutes the delicate spirit of a movement that has its roots in medieval hospitium. What remains today in a health system carelessly over-mechanizing its practice within a society that turns its back on the truth of that fluid charity of religious orders that knew how to welcome, attend, assist, care for and treat exhausted pilgrims [35] who had undertaken journeys with genuine hardship of those who did not know whether they would be able to return home?
The rigorous search for intangible fundamentals to make them available to all involved, within a strict research framework will result in new knowledge that, made available to all, results in undisputed palliative conceptions and important new paradigms.
The real impact on the defense of life in the context of an announced death is indisputably revealed by the immediate practical applicability of the theories used. These are issues that arouse great interest in acquiring greater knowledge, apprehensible by those who develop their clinical activity in this field.
The Anglo-Saxon Palliative Care, known among Spanish speakers as “Cuidados Paliativos”, changes the perspective from which we see the process of dying and death itself contributing to facilitate vital fullness and that the sick or close individual achieves his or her potential as a person even in the midst of complex multidimensional needs.
Cicely Saunders’original biography [36] relays how she established that one of its the modern Hospice movement underpinning values would be thinking and incorporating “Those who one day will come to join us” referring to professionals from diverse specialties, countries and bringing their own contribution to the field strengthening.
Undoubtedly the urgent demographic need means that many of us allow ourselves to call what is nothing more than a part of the original Palliative Care, a successor of Canadian origin of the previous “Terminal Care” [30, 32]. Contemporary Palliative Care has not made a full conceptual incorporation making, in my opinion, imperative the need to adjust foundational concepts.
International contemporary PC has not always made full conceptual incorporation, making it necessary the effort to adjust current impressions to the foundational ethos of the discipline, maybe contributing to the serious contemporary problem of PC’s lack of expansion in some places, even regressing in some countries unable to take roots in different cultures and new times. A phenomenon that could be contributing to a great confusion of what can be legitimately undertaken to facilitate the end of life.
The IAHPC. Global Consensus based palliative care definition [6], found it necessary to incorporate a glossary to define a long list of terms, an indication of the difficulty to agree on them when used in different languages and settings.
An example of this situation has come to worry many during the current pandemic: While in the Anglosaxon countries it is said to have come of age and helped reinforce services and support colleagues and professionals, in other countries, their activity has been reduced.
The growing interest in the political and institutional sphere PC has fostered in the COVID -19 demands increasing determination in its organizational assistance and political levels. Might It be possible that the careful conceptual clarification of terms common in the palliative field eases their extension and promotion? [36].
The depth of PC ethos, wherever it might lay, should be preserved to some level. Its transformation into Cuidados Paliativos is work in progress since 1989 [37] and continues to attract interest to clarify evolving conceptions [38]. It has slowly started moving over the years from Cuidados to a broader and less physical atención, (attention), to be true to its authentic foundational philosophy and inherent principles, their safeguarding of which should reflect the spirit of the modern hospice movement as it was when St Christopher’s Hospice first opened its doors. How it adapts and evolves is a central concern for many, characteristically uneasy about understanding how such ethos could be more widely established and how to prevent it from dissipation until lost, disappearing under the increasing technology laden healthcare services. It is worth getting to know the work undertaken by those for whom intangible aspects matter, precisely because they constitute the hospice movement founding heritage. A particular apprehension is that the “ethos” could be lost by spreading more widely if it is “marketed”, while losing its well-founded and carefully established approach to convey its philosophy and principles.
Interestingly, it precisely the collaborative effort between PC and other hospital specialties which is contributing significantly to its interdisciplinary progression and consolidation. The support of classic specialties, which once questioned the specific object of Palliative Medicine, a different entity from PC, is key to its advancement and development.
It is worthy of consideration the fact that Palliative Medicine is the only medical specialty that
Does not wrap its expertise around an organ, as Cardiology or Gastroenterology do; or group by age, as Geriatrics or Pediatrics do; or even an entity such as Infectious diseases or Virology.
Has adjectivized its specialism to qualify the medical expertise offered.
Is truly transverse across all other areas of expertise, from Neonatology to Neurosurgery passing through Organ Transplantation and Primary Care.
It is, therefore hardly surprising its practitioners need to explain what they do and who they are many times a day!
A recent piece work reviews some important milestones in PC’s history and development from which Palliative Medicine spirals in many countries; analyses its evolution in the world, studying current issues concerning consistency in its implementation and some possible projections for future progress and expansion, seen from the perspective of a central issue:
“What exactly constitutes the ethos of PC faithfully replicating its philosophy and founding principles wherever it is applied or used?” The author concludes that coming to that knowledge would help facilitate possible future advances that integrate ethical, legal and social implications in years to come that truly benefit those with palliative needs.
PC delivery and benefits fall under the Philosophy Phenomenological arena while the conceptualization of the main terms on which research is centered around its practice, as the phenomenon investigated. Conceptual construction. Life to its end is a prodigy in progress. Images and s never seen before, thoughts never before thought, realities never dreamed of, constantly emerging, constantly reminding that individual universe that it has not yet reached the limits of its possibilities. The essence of PC could well be life that remains as such, as an evolving universe. Or perhaps the sick person’s journey to his deepest self than the professional is more of a witness than an escort.
To identify themes to be found in the English and Spanish literature a systematic search was conducted (Table 1).
MESH Terms
“Palliative” (and) “Care” (and) “Ethos”
32
Other non-randomized, quasi-experimental, descriptive (comparative, correlation), case–control, cohort studies
1
Reports or opinions from expert committees or the clinical experiences of respected authorities
1
Systematic reviews and meta-analysis. Controlled Randomized studies
8
Books and Book Chapters
9
Clinical guides, documents
2
Thesis
Table 1.
Palliative care ethos literature review.
From those, the summary, the most important ideas to consider include
Palliative Care comes to change the perspective from which we see the process of dying and death itself contributing to facilitate the vital fullness and that the sick or close individual achieves his potential as a person even in the midst of complex multidimensional needs.
Cicely Saunders, as included in her biography [2], spoke of the PC bases would include “Openness to those who will come” referring to professionals from diverse countries and cultures who, one day, would join the Modern Hospice Movement. They would bring new ways to alleviate and contribute their own culture, ways of doing and even different specialties and specific needs in the final phase of different diseases. Another base was to be the Freedom of the Spirit.
Wanting to know what constitutes the essence of PC is a complex task; our search shows the need to do an in-depth analysis of the terminology used and its conceptual adequacy.
A relevant finding was the fact that other concepts such as essence, might be used to make reference to what philosophy and ethos bring. “Essence” is a term of alchemy from Latin essere (to be), then arguably embodies “meaning”, “purpose”. From a metaphysical point of view, it could be considered as the possibility of filling the living space of the individual with information gained through experience.
5. Conceptualization
To the scholar mind, a multi-faceted approach is prerequisite to adequately conceive PC from the conceptual, semantic and meaning, anthropological, philosophical and political angles without forgetting that of actively caring for others´ wellbeing and assisting them. There could be different ways to unveil its intrinsic philosophy by seeking what imprints character to a movement which began well before Medicine itself was considered an entity, from the medieval hospitium [39] (pl hospitia) hɒˈspɪtɪə Greek: ξενία, xenia, προξενία and positions the scholar in front of is the ancient Greco-Roman concept of hospitality as a divine right of the guest and a divine duty of the host. An archaic place of shelter for travelers, especially one kept by a monastic order, that we are trying nowadays to adapt to a very different society with unmet needs.
The encounter with the ancient vocables that give name to this caring movement whets the scholar’s appetite to learn more about the semantic and semiotic correspondence of the most commonly used words in PC in order to fully understand the impact of language and its own development in its evolution.
A straightforward methodology pathway leads us to study the roots of the discipline key words, analyzing their semantic transformation over time to witnessing their morphological evolution and conceptual spirit of each vocable. Grounded on a careful conceptual description of those words used in the palliative field could facilitate its extension and promotion which should benefit more people.
5.1 Language and conceptualization
Linguistics is a science which object of study is language. Its analysis places language in context, as it takes into consideration social, cultural, historical, and political factors influencing language.
Conceptualization consists of processes observing language production. It takes language-specific perspectives and event understanding.
Such process is still little understood by the experts [40] in the field. At the same time, we find ourselves at a point in the history of the Modern Hospice movement when it seems to be imperious to start a rigorous process around strong, concise and unambiguous definitions. This is due to the expansion of the discipline throughout the different countries with their cultures and languages which need to adapt to a new way of formalized compassion. Within PC, too many words are translated almost literally from the English language, resulting in numerous concepts with multiple scopes or dimensions, often inaccurate. This is confusing and makes it hard to transmit the science to others outside the field as they are incapable of conceiving its objective without further clarification. Existing PC definitions are being currently contested, probably because concepts are neither tangible nor concrete. Characterizations of our field based on abstract concepts make for confusion needing an effort to interpret conceptually by act or process of forming a general notion or idea.
Interest in this matter comes from personal experience of palliation in both the Anglo-Saxon and Iberian cultures and language and observing the inadequate adoption of terminology without the right notions behind. We defend the proposition that it is important to know what notions different authors might use to refer to PC and establish which of those most faithfully represent its most intimate nature.
There are interesting efforts to establish useful, replicable models. Some are orientated to [41] building digital domain ontologies, incredibly interesting and potentially game changing in niche areas used across the world. However, the model chosen to conceptualize is one by Flores Talavera G. [42] for reasons relating to its clarity, teaching dimension and the fact that she writes in Spanish.
Professor Talavera’s process guides the investigator to initiate conceptualization by undertaking documentary research on the meaning of the key terms; including a review of the meanings and clarification of semantic confusions, looking at the appropriate dictionaries to contextualize it and learn about the possible conceptual evolution of the term. She then suggests consultation of Thesauruses in which the terms are described in the way they are used by scientists followed by accounting for the definitions of the term from a specific perspective. - In specialized dictionaries (Philosophy, Psychology, Sociology, and Physicians and Education) and conceptual essays, definitions located in sources to broaden the search horizon to find the “sense” of the term.
It is then possible to compare related terms using three processes: defining each one of them, establishing similarities and then establishing differences. This would then facilitate term characterization by establishing its most important characteristics, not of the word but of the complex reality that the term tries to elucidate.
To consider types and uses of the object (term) of study from its conceptual definition and expand the understanding of the meaning and reality intended to be explained, it is useful to identify the key ones.
5.2 Palliative care conceptualization
Conceptual purity of words used in the palliative field could facilitate its extension and promotion by examining its intrinsic philosophy understanding what it is that imprints character to a movement that began from the medieval hospitium and has foundational Judeo- Christian roots.
Applying the chosen methodology to the conceptualization and semantics of the original Palliative Care entails an interesting linguistic and geographical iter that could decisively contribute to the dissolution of the original karos philosophy observed in some situations. There should have been a process of content-rich implementation, in its place this is truncated by a less nuanced implementation marked by external and constant pressure to achieve tangible and quantitatively relevant results.
5.2.1 Representative terms and words used in international palliative care
The number of terms that could be analyzed in order to be conceptualized could might be thought to be huge. This is not the case as there are a handful of terms, key to impulse palliative programs (Table 2).
Dates from
Meaning
Original language (s)
Contemporary use
Of note
Hospice noun Hospitium
late 17th century.1818.
Rest house for travellers
French hospice "hospital, almshouse" Old French ospice "hospice, shelter," ,"hospitality," 13c. Latin 1. hospitium "hospitable reception, entertainment; hospitality, bonds of hospitality, relationship of guest and host 2.hospes (genitive hospitis) "guest; host," also "a stranger, foreigner"
1879.Sense of "home for the aged and terminally ill " 1978is first attested as hospice movement
The term “Hospice” is strongly repudiated in Spanish- Palliative Care Unit is used instead Used in the Netherlands as Hospitium, places for those who don’t want euthanasia and go there for protection.
Implement verb implemere noun Implementum
Verb. early 18th century. 1707 Noun, in late Middle English. First used circa 1707c. in Scottish English. Legal term meaning "fulfilment,"
Verb: 1.-To put (a decision, plan, agreement, etc.) into effect. 2.- To start using a plan or system 3.- To complete, perform, carry into effect," Noun Used to refer to different artifacts: furniture, gear, or dress’.
Late Latin: implementum; implere: filling up Made of two Latin vocables In (towards the center) Plere (to fill up) (Greek polis, many) Partly from Medieval Latin implementa (plural Partl from late Latin Implementum ‘filling up, fulfilment’, both from Latin implere ‘fill up’ (later ‘employ’), from in- ‘in’ + Latin plere ‘fill’.
From it comes implementation, its use first recorded 1913.
Implant verb Noun
16th Century 1540c 15th Century
Verb I.Transitive 1a: to fix or set securely or deeply 1b: to set permanently in the consciousness or habit patterns: inculcate 2. to insert in living tissue II.Intransitive To undergo implantation Noun graft "to plant in" abstractly, of ideas, emotions, etc. "to plant", literally "plant in," from assimilated form of in- "into, in, on, upon". --
Old French Emplanter French “to insert, engraft” Medieval Latin. Implantus In (towards the centre) Plant (see in, to plant, and observe)
Noun Modern use From 1886 Meaning "surgically implant (something) in the body", originally of teeth. which is attested by 1981 short for breast implants (1976). 1890, "thing implanted;" 1941 as "action of implanting," from implant
If you implant an idea or attitude in people, you make it become accepted or believed.
IMPLEMENT /IMPLANT
The difference between the notions conceived through these two verbs is very important. Implementing a Palliative Care Program speaks of “working at it” and “being part of the development”. While implanting a Palliative Care Program talks about “having something new to deal with or to put up with”. Something that needs to be taken into account by politicians, managers, et as it might mean the difference between people being engaged or not.
PALLIATIVE ADJ. PALLIATIF PALLIATUS VERB NOUN PALLIATIVUS VERB LATIN PALLIARE
Early 15c., Dates from 1724. As a verb, used since 1779.
"serving to mitigate or alleviate" (a wound, illness, etc.); other meanings "cloak, cover, concealing;" from "under cloak, covert," from Latin pallium "a cloak" ‘to cloak’, ´to protect´ ´to conceal,"
Adj. French Palliatif, Late Latin Palliatus "cloaked," from past participle of Late Latin palliare "cover with a cloak, conceal," Noun. Medieval Latin palliativus Verb. Medieval Latin palliare
"serving to extenuate by Excuses or favorable representation". "that which mitigates or extenuates,". Used by politicians and journalists to express strong actions or will.
CARE Noun Verb
circa. 1400 Circa 1580. Circa 1520s- 1550s
a. the provision of what is necessary for the health, welfare, maintenance, and protection of someone or something. (safe keeping, supervision, custody,charge, protection,keeping) b. serious attention or consideration applied to doing something correctly or to avoid damage or risk. (caution, carefulness, wariness,awareness, heedfulness,heed) D. Meaning "object or matter of concern" is from To take care of "take in hand, do"; take care "be careful" also is from Negative sense 1.Old English "To be anxious or solicitous; grieve; feel concern or interest, 2. "Proto-Germanic "grief, care" 3. Old Saxon karon "to lament, to care, to sorrow, complain," 4. Old High German "complain, lament," 4.Gothic karon "to be anxious"), said to be from PIE root *gar- "cry out, call, scream" (source also of Irish gairm "shout, cry, call;"). 6. Latin “curar”. think, consider. Positive sense senses, such as "have an inclination"; "have fondness for" seem to have developed later as mirrors to the earlier negative ones. a. feel concern or interest; attach importance to something. (be concerned,worry (oneself) trouble oneself, bother,mind) b. look after and provide for the needs of. (look after, take care of, tend, attend to,mind, minister to
Old English caru, cearu "sorrow, anxiety, grief," also "burdens of mind; serious mental attention" Late Old English "concern, anxiety caused by apprehension of evil or the weight of many burdens," Proto-Germanic *karō "lament; grief, care" Source also of Old Saxon kara "sorrow;". The primary sense is that of inward grief, and the word is not connected, either in sense or form, with L. cura, care, of which the primary sense is pains or trouble bestowed upon something. [Century Dictionary] Old High German chara "wail, lament;" Gothic kara "sorrow, trouble, care”. 1.Old English carian, cearian 2. "Proto-Germanic *karo- "lament," 3. Old Saxon karon 4. Old High German charon 5.Gothic karon "to be anxious" said to be from PIE root *gar- "cry out, call, scream" (source also of Irish gairm "shout, cry, call;"). 6. Latin Cogitatus, cura. Co (combined, global) Agitare (to get moving, agitate, think things through) Cogitare – to think with movement. (To be moved to…)
C."charge, oversight, attention or heed with a view to safety or protection" is attested from; The sense in care of in addressing (used from 1840).
Of all the different meanings of Care, only Cuidados & Cura are used in Spanish. There is a reluctance to Attend, Assist, have regard for etc..
ATTEND Aspect of Care Verb Attention Aspect of Care Noun
Late 14c. 12c 14c
a."giving heed," "attention, attentiveness," b. "to direct one\'s mind or energies," "Mental heeding" "give heed to," literally "to stretch toward", "be subject to" (now obsolete), "direct one\'s mind or energies" (archaic), from (…)
Both verb and noun share origen from two Latin vocables a. Latin attentionem (nominative attentio) ad "to, toward" + tendere "stretch," b. Old French “atendre”
Very little in Spanish Palliative Care
Attention "Mental heeding" This finding is highly relevant as id directed related to Cicely Saunders´s “Active listening”
ASSIST Aspect of Care Verb
early 15c 14c
assisten ‘take one\'s stand’. stand by, take a stand near, attend," to set, place, cause to stand," assister "to stand by, help, put, place, assist" to help someone, aid, collaborate, cooperate, benefit
Origen from two Latin vocables Ad- to; + iuvare – "to help" from ad- ‘to, at’ + sistere Late Middle English, from Old French Latin assister "
Related: Assisted; assisting gives way to Medical assisted suicide attested from 1884
INSIST Aspect of Care
1580s 14c.
"take a stand, stand on, stand still; follow, pursue; insist, press vigorously, urge, dwell upon," from in- "upon" "take a stand," from PIE *si-st-, reduplicated form of root *sta- "to stand, make or be firm."
French insister Or directly from Latin insistere from root *en "in") + sistere
Interesting use of insist tends to happen when patient´s symptoms or family anguish are present.
ASSISTANCE & ASSIST Aspects of Care Noun(s).
early 15c., 1570s
take one\'s stand by’, ‘take one\'s stand’. "act of helping or aiding; help given, aid," from the respective verbs "to help, aid, give assistance or support to in some undertaking or effort," "stand by, take a stand near, attend," To take a stand; to set, place, cause to stand"an act of assistance," from assist" stand still.
Late Middle English: from Old French assister, from Latin assistere ‘from ad- ‘to, at’ + sistere from Old French assistance and Medieval Latin assistentia, Late Latin adjuva Latin assistere from assimilated form of ad "to" + sistere
Table 2.
Palliative care terminology: vocables evolution through time and languages
However, there is a number of them that deserve immediate attention as they are used, maybe even abused, too frequently. An appropriate conceptualization of these is urgent due to their weight in planning, policy – making and the delivery of excellent Palliative Care.
Although it is a very specialized subject and deserves a full piece of work with more specialist direction, we present a first attempt here.
To begin with, and following the first two process points from guideline, we can start from the top of the organizational and planification pyramid from which all policy flows to inform health and social care, there are two vocables that could be used better to achieve the sought-after results.
I. Hospice
Noun.
Dates from late 17th century, 1818.
Meaning: 1. Greek: ξενία, xenia, προξενία.
2. “rest house for travellers”
From: Greco-Roman concept of hospitality as a divine right of the guest and a divine duty of the host.
French hospice “hospital, almshouse”.
Old French ospice “hospice, shelter,” also “hospitality,” 13c.),
From Latin hospitium “hospitable reception, entertainment; hospitality, bonds of hospitality, relationship of guest and host.
From hospes (genitive hospitis) “guest; host,” also “a stranger, foreigner”.
and positions the scholar in front of is the ancient.
Meaning: 1. To put (a decision, plan, agreement, etc.) into effect.
2. To start using a plan or system
3. To complete, perform, carry into effect,” 1707
From Late Latin: implementum; implere: filling up.
Made of two Latin vocables
In (towards the center)
Plere (to fill up) (Greek polis, many)
Noun. /ˈɪmplɪmɛnt/
Used in late Middle English to refer to different artifacts: furniture, gear, or dress’. Originates in part from the medieval Latin implementa (plural), in part from late Latin implementum ‘filling up, fulfilment’, both from Latin implere ‘fill up’ (later ‘employ’), from in- ‘in’ + Latin plere ‘fill’.
First used circa 1707 initially in Scottish English. As a noun it was a legal term meaning “fulfillment,” From it comes implementation, its use first recorded 1913.
1b: to set permanently in the consciousness or habit patterns: inculcate
2: to insert in living tissue
II. Intransitive verb
To undergo implantation.
If you implant an idea or attitude in people, you make it become accepted or believed.
Medieval latin.
In (towards the center).
Plant- see in, to plant, and observe.
implant (v.)
1540s, “to plant in” (abstractly, of ideas, emotions, etc.), from French implanter “to insert, engraft” (alongside Old French emplanter “to plant”), literally “plant in,” from assimilated form of in- “into, in, on, upon” (from PIE root *en “in”) + planter “to plant” (see plant (n.)). Meaning “surgically implant (something) in the body” is from 1886, originally of teeth. Implanted is attested earlier, from early 15c., probably based on Medieval Latin implantus. Related: Implanting.
Noun.
implant (n.)
1890, “thing implanted;” 1941 as “action of implanting,” from implant (v.). Related: Implants, which is attested by 1981 as short for breast implants (1976).
late Middle English: from late Latin implantare ‘engraft’, from Latin in- ‘into’ + plantare ‘to plant’. (Oxford Languages Definitions)
implant (v.) 1540s, “to plant in” (abstractly, of ideas, emotions, etc.), from French implanter “to insert, engraft” (alongside Old French emplanter “to plant”), literally “plant in,” from assimilated form of in- “into, in, on, upon”. (Online Etymology dictionary).
Relevance: The difference between the notions conceived through these two verbs is very important. Implementing a Palliative Care Program speaks of “working at it” and “being part of the development”. While implanting a Palliative Care Program talks about “having something new to deal with or to put up with” Something that needs to be taken into account by politicians, managers, et as it might mean the difference between people being engaged or not.
IV. Palliative Care
The term “Cuidados Paliativos” (Spanish/Portuguese) seem not to have incorporated the richness of meaning Palliative Care has afforded those who request, practice and receive it in the Anglo-Saxon context.
IV.a. Palliative
As a concept, in my experience, requires much explanation to those who encounter it for the first time, both as a patient or carer and as professionals. Explaining its meaning and aims to the general public can be very challenging indeed, although it must be said it has brought about really creative ways of explaining it in a practical way.
It is said that its use in English has seen a significant increase in the last 200 years due to the development of Palliative Care. Its Spanish translation is often used in politics such as in “we are going to remedy such a situation without palliatives”, as a plural, indicaring with harshnesh.
The Spanish and Portuguese vocables “Cuidar” and “Cuidados” fall short of representing its multiple meanings within this context. The question to try to answer is: could this happen because it ignores certain conceptual aspects such as those of “that I care about the other”, “care”, “pay attention”, “assist”, “give assistance to”, “medically treat.” beyond “hacer curas” (wound and dressing management) and “curar” (cure in English) that has been reduced to in the Spanish language (while trying to offer its whole range of attentions)?
1. Noun
Origen
Old English caru, cearu “sorrow, anxiety, grief,” also “burdens of mind; serious mental attention”.
Late Old English “concern, anxiety caused by apprehension of evil or the weight of many burdens,”
Proto-Germanic *karō “lament; grief, care” (source also of Old Saxon kara “sorrow;”. The primary sense is that of inward grief, and the word is not connected, either in sense or form, with L. cura, care, of which the primary sense is pains or trouble bestowed upon something. [Century Dictionary].
Old High German chara “wail, lament;” Gothic kara “sorrow, trouble, care”.
Dates from c. 1400
Meanings.
the provision of what is necessary for the health, welfare, maintenance, and protection of someone or something. (safe keeping, supervision, custody,charge, protection,keeping)
serious attention or consideration applied to doing something correctly or to avoid damage or risk. (caution, carefulness, wariness, awareness, heedfulness, heed)
“charge, oversight, attention or heed with a view to safety or protection” is attested from;
The sense in care of in addressing (1840).
Meaning “object or matter of concern” is from 1580.
To take care of “take in hand, do” is from 1580s; take care “be careful” also is from 1580s.
2. Verb
Dates from
a. Old English carian, cearian.
Meanings
”be anxious or solicitous; grieve; feel concern or interest,
“to lament, to care, to sorrow, complain,” Old High German charon “complain, lament,”
Gothic karon “to be anxious”), said to be from PIE root *gar- “cry out, call, scream” (source also of Irish gairm “shout, cry, call;”).
If so, the prehistoric sense development is from “cry” to “lamentation” to “grief.” A different sense evolution is represented in related Dutch karig “scanty, frugal,” German karg “stingy, scanty.” It is not considered to be related to Latin cura. Positive senses, such as “have an inclination” (1550s); “have fondness for” (1520s) seem to have developed later as mirrors to the earlier negative ones.
a. feel concern or interest; attach importance to something. (be concerned, worry (oneself), trouble oneself, bother, mind).
b. look after and provide for the needs of. (look after, take care of, tend, attend to, mind, minister to).
Old English caru (noun), carian (verb), of Germanic origin; related to Old High German chara ‘grief, lament’, charon ‘grieve’, and Old Norse kǫr ‘sickbed’.
Proto-germanic. Karo. “Lament, grief, Care”.
Old Saxon. Chara; wail, lament.
Old high German. Charon To wail.
Old English. Carucearu. “Sorrow, anxiety, grief”.
Old English. Carian, cearian. “Be anxious, to grief, to feel concern”.
“CARE”.
To find the Spanish Cuidados translation, we need to look further and find how care has other interesting close relations that help work with a more active manner of manifesting one’s need of being attended to.
Cogitatus (Latin)
Origin & history
Perfect passive participle of cōgitō (“think, consider”).
Old French Latin assister “stand by, take a stand near, attend,”
from assimilated form of ad “to” (see ad-) + sistere “stand still, take a stand; to set, place, cause to stand,”
from PIE *si-st-, reduplicated form of root *sta- “to stand, make or be firm.”
Latin assister Take one’s stand by”.
Originates
1. early 15c., assisten, “to help, aid, give assistance or support to in some undertaking or effort,”
2. 14c old French assister “to stand by, help, put, place, assist”
Dates
to help someone, aid, collaborate, cooperate, benefit.
IV.b4 To Insist
Dates 1580s,
Originates
French insister (14c.)
Or
directly from Latin insistere.
“take a stand, stand on, stand still; follow, pursue; insist, press vigorously, urge, dwell upon,” from in- “upon”.
(from PIE root *en “in”) + sistere “take a stand,” from PIE *si-st-, reduplicated form of root *sta- “to stand, make or be firm.”
assist (v.) Related: Assisted; assisting. Medical assisted suicide attested from 1884.
IV.b5 Assistance
late Middle English: from Old French assister, from Latin assistere ‘take one’s stand by’, from ad- ‘to, at’ + sistere ‘take one’s stand’.
Noun.
“act of helping or aiding; help given, aid,” from the respective verbs.
Dates
early 15c.,
Originates from
from Old French assistance and Medieval Latin assistentia, Late latin adjuva
Meaning
“to help, aid, give assistance or support to in some undertaking or effort,”
Originates
Latin assistere
“stand by, take a stand near, attend,”
from assimilated form of ad “to” (see ad-) + sistere “stand still,
Meaning
To take a stand; to set, place, cause to stand,
“from PIE *si-st-, reduplicated form of root *sta- “to stand, make or be firm.”
Related: Assisted; assisting. Medical assisted suicide attested from 1884.
assist (n.) 1570s, “an act of assistance,” from assist.
late Middle English: from Old French assister, from Latin assistere ‘take one’s stand by’, from ad- ‘to, at’ + sistere ‘take one’s stand’.
6. Conclusion
Can you say something to comfort me? The Polish man Cicely Saunders considered to have been the Palliative Care patient to set the bases for the Modern Hospice Movement, asked her. A beautiful research question which proves incredibly difficult to give an answer to in a timely, honest and personalized way [46, 47]. A question that demands words constructed and delivered in a soothing, comforting manner. A question that leaves out action, doing to, as we often want to do: administering medication, offering therapeutic and surgical options less sought than human verbal interaction.
Language in its different forms is very important to transmit knowledge, affection, security … and so much more too. PC uses not only spoken and written language but also body language. Language requires the support of concepts known, accepted and used by most. We conclude that too often those notions are not crystal clear and can provoke rejection, fear, isolation, doubt and increase the very suffering they should help alleviate.
Standing for and advocating for the promoting and contributing to the expansion and of Palliative Care [48], clear messages are important to avoid creating confusion. These messages should state truths such as “Palliative Care facilitates the process of dying without interfering with its natural course beyond the legitimate and ethical limits”. It’s a complex phenomenon that recognizes the intrinsic reality of professional work while touching on the most humane and compassionate principles of the art of palliating.
Today there is no doubt that the expansion and scope of Palliative Care is neither the desired nor the necessary [49]. In this the agreement is widespread. Where there is no agreement is in why this situation and therefore how to overcome it.
To appreciate and love something, it is necessary to know it. The better we know it, the easier it becomes to enjoy its bounties. The less we know it, the longer it will take us to accept it while finding what is needed to accept its place in our lives.
How much more difficult it is to accept something new when our life is threatened by a medical condition and we feel forced to face our own mortality. This is the reality found by professionals who try to introduce Palliative or Supportive Care to reinforce the person’s own strengths, both natural and acquired.
It is at that point that the professional needs to give the sick and their family a master class on what they do, what they offer, where and when. Were they going to be seen by the cardiologist, the question might be “is that for the heart?” The number of questions that come up before accepting Palliative or Supportive Care are many more and are related to many different facets and it takes time to address each one of them appropriately. It has been the linguistic, semantic and its meaning and their impact on the patient’s outcome that has fascinated me after many years working in the field and observing the change in the often the angry, frightened and frustrate people I meet when responding to a colleague’s call for help and the relaxed, understanding, grateful and collaborative demeanor in the, by then patient under our care, we leave behind. Often part of our goodbye includes the question “will we see you again?” We have managed to establish a connection with the patient by spending time with them and their family and by talking to them about our role in their situation.
At a time when reassurance, otherness and presence can communicate so much, the power of language is immense in relationships that are short at the same time as they are intense.
Our work confirms the power of words and the importance of exerting the Active Listening key in the holistic care promoted by Cicely Sanders to alleviate Total Pain [7]. It pioneers in the recognition of scientific linguistics as fundamental to improve delivery of Palliative Care improving quality of translation to new languages. This will need promoting due care is taken by working towards methodologically scientific ways of conceptualization in language production with language-specific perspectives and event construal for different cultures who communicate in different languages.
An exciting topic to research, Palliative Care Linguistics will need further work in the future because, just as Cicely Saunders said about pain “There is so much to learn about explaining palliative concepts and the models of care!”
This chapter invites the reader to recognize the relationship between the expansion of PC and the appropriate conceptualization of the ideas, terminology and words used by those working in what constitutes its “deepest core”, where its true significance is.
Additional information
Figures in this chapter are adapted from Oxford Languages Definitions & Online Etymology Dictionary.
\n',keywords:"palliative care, scientific conceptualization, linguistics, advocacy, ethos, spirituality",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/76630.pdf",chapterXML:"https://mts.intechopen.com/source/xml/76630.xml",downloadPdfUrl:"/chapter/pdf-download/76630",previewPdfUrl:"/chapter/pdf-preview/76630",totalDownloads:203,totalViews:0,totalCrossrefCites:0,dateSubmitted:"November 3rd 2020",dateReviewed:"March 22nd 2021",datePrePublished:"June 16th 2021",datePublished:"July 21st 2021",dateFinished:"May 6th 2021",readingETA:"0",abstract:"The need for Palliative Care (PC) continues to grow throughout the world, requiring continuous development, true to its “ethos.” As awareness grows so does the expectation for timely response and policies to potentiate its delivery. The scientific dimension of its philosophy, underpinned by research and scientific practice, looks to explain its nature, origin and concepts, models and theories within which it is delivered. The concept palliation is widely used; yet, it is understudied by academics and clinicians. Interestingly, it is increasingly questioned by society and other specialists, calling for it to “be debated and essentially contested”. Our aim is to contribute to society’s understanding of palliative care so that they can have a clear and truthful awareness of the complex implications of its mission. We approach the different concepts, scientific theories and structures can be achieved by following different pathways, including defining its “ethos”: personality or nature, manifest in the very formulae by which PC places itself before those who need it. What a fascinating topic it is to research and write on!, phenomenological in its base, it shows how different translations of the Anglo-Saxon PC influence its understanding and much needed expansion. Semiotics are at the base of the essence of how palliative care might be assumed and promoted. PC is, for sure, one of the most important, existential spheres to apply our knowledge today and a novel promising methodology to apply the semiotic and phenomenological approaches learning of different aspects of cultural transfer processes.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/76630",risUrl:"/chapter/ris/76630",signatures:"Maria Teresa Garcia-Baquero Merino, María Victoria Roqué Sánchez, Katherine Pettus and Micaela Menarguez Carreño",book:{id:"10456",type:"book",title:"Suggestions for Addressing Clinical and Non-Clinical Issues in Palliative Care",subtitle:null,fullTitle:"Suggestions for Addressing Clinical and Non-Clinical Issues in Palliative Care",slug:"suggestions-for-addressing-clinical-and-non-clinical-issues-in-palliative-care",publishedDate:"July 21st 2021",bookSignature:"Marco Cascella and Michael John Stones",coverURL:"https://cdn.intechopen.com/books/images_new/10456.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:"978-1-83969-153-9",printIsbn:"978-1-83969-152-2",pdfIsbn:"978-1-83969-154-6",isAvailableForWebshopOrdering:!0,editors:[{id:"199335",title:"Dr.",name:"Marco",middleName:null,surname:"Cascella",slug:"marco-cascella",fullName:"Marco Cascella"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"338310",title:"Dr.",name:"María Teresa",middleName:null,surname:"García-Baquero Merino",fullName:"María Teresa García-Baquero Merino",slug:"maria-teresa-garcia-baquero-merino",email:"mtgarcia@ucam.edu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"415008",title:"Dr.",name:"María Victoria",middleName:null,surname:"Roqué Sánchez",fullName:"María Victoria Roqué Sánchez",slug:"maria-victoria-roque-sanchez",email:"mvicro@gmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"415009",title:"Dr.",name:"Katherine",middleName:null,surname:"Pettus",fullName:"Katherine Pettus",slug:"katherine-pettus",email:"kpettus@iahpc.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. The purpose of medicine",level:"1"},{id:"sec_3",title:"3. Palliative care",level:"1"},{id:"sec_3_2",title:"3.1 Meaning and fullness of worth within the health and social contexts",level:"2"},{id:"sec_4_2",title:"3.2 Modern hospice movement evolution",level:"2"},{id:"sec_5_2",title:"3.3 Limits of action: caring, not killing",level:"2"},{id:"sec_6_2",title:"3.4 Scientific aspects",level:"2"},{id:"sec_6_3",title:"3.4.1 The science and its philosophy",level:"3"},{id:"sec_8_2",title:"3.5 Patient centred and directed palliation effort: quality of life",level:"2"},{id:"sec_10",title:"4. Chapter motivation and scientific interest",level:"1"},{id:"sec_11",title:"5. Conceptualization",level:"1"},{id:"sec_11_2",title:"5.1 Language and conceptualization",level:"2"},{id:"sec_12_2",title:"5.2 Palliative care conceptualization",level:"2"},{id:"sec_12_3",title:"Table 2.",level:"3"},{id:"sec_15",title:"6. 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Universidad Católica San Antonio de Murcia (UCAM), Spain
Palliative Care Consultant, UK
Madrid first Regional Palliative Care Coordinator 2008–2016
'},{corresp:null,contributorFullName:"María Victoria Roqué Sánchez",address:null,affiliation:'
Universidad Católica San Antonio de Murcia (UCAM), Spain
Universidad Católica San Antonio de Murcia (UCAM), Spain
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He has supervised twenty-five postgraduate and six doctoral students and has eleven years of research and teaching experience. He is currently working on the three externally funded projects (DST, MHRD, ICAR) with one patent. Dr. Meena has published more than 110 research and review papers, 65 book chapters, and 20 books. He has worked as an expert for the National Council of Educational Research and Training (NCERT), MHRD, and GOI. 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IntechOpen’s Academic Editors and Authors have received funding for their work through many well-known funders, including: the European Commission, Bill and Melinda Gates Foundation, Wellcome Trust, Chinese Academy of Sciences, Natural Science Foundation of China (NSFC), CGIAR Consortium of International Agricultural Research Centers, National Institute of Health (NIH), National Science Foundation (NSF), National Aeronautics and Space Administration (NASA), National Institute of Standards and Technology (NIST), German Research Foundation (DFG), Research Councils United Kingdom (RCUK), Oswaldo Cruz Foundation, Austrian Science Fund (FWF), Foundation for Science and Technology (FCT), Australian Research Council (ARC).
Open Access publication costs can often be designated directly in the grants or in specific budgets allocated for that purpose. Many of the most important funding organisations encourage, and even request, that the projects they fund are made available at no cost to the wider public. IntechOpen strives to maintain excellent relationships with these funders and ensures compliance with mandates.
\\n\\n
In order to help Authors identify appropriate funding agencies and institutions, we have created a list, based on extensive research on various OA resources (including ROARMAP and SHERPA/JULIET) of organizations that have funds available. Before consulting our list we encourage you to petition your own institution or organization for Open Access funds or check the specifications of your grant with your funder to ascertain if publication costs are included. Where you are in receipt of a grant you should clarify:
\\n\\n
\\n\\t
Does your institution already have a budget for covering Open Access publication costs?
\\n\\t
Does your grant list Open Access publication fees as legitimate direct/indirect costs?
\\n
\\n\\n
If you are associated with any of the institutions in our list below, you can apply to receive OA publication funds by following the instructions provided in the links. Please consult the Open Access policies or grant Terms and Conditions of any institution with which you are linked to explore ways to cover your publication costs (also accessible by clicking on the link in their title).
\\n\\n
Please note that this list is not a definitive one and is updated regularly. To suggest possible modifications or the inclusion of your institution/funder, please contact us at funders@intechopen.com
\\n\\n
Please be aware that you must be a member, or grantee, of the institutions/funders listed in order to apply for their Open Access publication funds.
Open Access publication costs can often be designated directly in the grants or in specific budgets allocated for that purpose. Many of the most important funding organisations encourage, and even request, that the projects they fund are made available at no cost to the wider public. IntechOpen strives to maintain excellent relationships with these funders and ensures compliance with mandates.
\n\n
In order to help Authors identify appropriate funding agencies and institutions, we have created a list, based on extensive research on various OA resources (including ROARMAP and SHERPA/JULIET) of organizations that have funds available. Before consulting our list we encourage you to petition your own institution or organization for Open Access funds or check the specifications of your grant with your funder to ascertain if publication costs are included. Where you are in receipt of a grant you should clarify:
\n\n
\n\t
Does your institution already have a budget for covering Open Access publication costs?
\n\t
Does your grant list Open Access publication fees as legitimate direct/indirect costs?
\n
\n\n
If you are associated with any of the institutions in our list below, you can apply to receive OA publication funds by following the instructions provided in the links. Please consult the Open Access policies or grant Terms and Conditions of any institution with which you are linked to explore ways to cover your publication costs (also accessible by clicking on the link in their title).
\n\n
Please note that this list is not a definitive one and is updated regularly. To suggest possible modifications or the inclusion of your institution/funder, please contact us at funders@intechopen.com
\n\n
Please be aware that you must be a member, or grantee, of the institutions/funders listed in order to apply for their Open Access publication funds.
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On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. 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From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. 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After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. 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In this article, transition metal oxides such as TiO2-V2O5, NiMn2O4 etc. with porous structure are considered as high performance supercapacitors electrode. The effects of its structural, morphological and electrochemical properties have been studied extensively. A TiO2-V2O5 and NiMn2O4 based electrode delivered specific capacitance of 310 and 875 F g−1, respectively at a scan rate 2 mV s−1. This TiO2-V2O5 based asymmetric supercapacitor also exhibits excellent device performance with specific energy 20.18 W h kg−1 at specific power 5.94 kW kg−1, and retained 88.0% specific capacitance at current density of 10 A g−1 after 5000 cycles.",book:{id:"7567",slug:"science-technology-and-advanced-application-of-supercapacitors",title:"Science, Technology and Advanced Application of Supercapacitors",fullTitle:"Science, Technology and Advanced Application of Supercapacitors"},signatures:"Apurba Ray, Atanu Roy, Samik Saha and Sachindranath Das",authors:[{id:"24791",title:"Dr.",name:"Sachindra Nath",middleName:null,surname:"Das",slug:"sachindra-nath-das",fullName:"Sachindra Nath Das"},{id:"255864",title:"MSc.",name:"Apurba",middleName:null,surname:"Ray",slug:"apurba-ray",fullName:"Apurba Ray"},{id:"255910",title:"MSc.",name:"Atanu",middleName:null,surname:"Roy",slug:"atanu-roy",fullName:"Atanu Roy"},{id:"255912",title:"MSc.",name:"Samik",middleName:null,surname:"Saha",slug:"samik-saha",fullName:"Samik Saha"}]},{id:"16966",doi:"10.5772/18545",title:"Transparent Conductive Oxide (TCO) Films for Organic Light Emissive Devices (OLEDs)",slug:"transparent-conductive-oxide-tco-films-for-organic-light-emissive-devices-oleds-",totalDownloads:16530,totalCrossrefCites:10,totalDimensionsCites:20,abstract:null,book:{id:"253",slug:"organic-light-emitting-diode-material-process-and-devices",title:"Organic Light Emitting Diode",fullTitle:"Organic Light Emitting Diode - Material, Process and Devices"},signatures:"Sunyoung Sohn and Yoon Soo Han",authors:[{id:"31808",title:"Prof.",name:"Yoon Soo",middleName:null,surname:"Han",slug:"yoon-soo-han",fullName:"Yoon Soo Han"},{id:"91912",title:"Dr.",name:"Sunyoung",middleName:null,surname:"Sohn",slug:"sunyoung-sohn",fullName:"Sunyoung Sohn"}]},{id:"60131",doi:"10.5772/intechopen.74136",title:"Dielectric Elastomers for Energy Harvesting",slug:"dielectric-elastomers-for-energy-harvesting",totalDownloads:1253,totalCrossrefCites:9,totalDimensionsCites:16,abstract:"Dielectric elastomers are a type of electroactive polymers that can be conveniently used as sensors, actuators or energy harvesters and the latter is the focus of this review. The relatively high number of publications devoted to dielectric elastomers in recent years is a direct reflection of their diversity, applicability as well as nontrivial electrical and mechanical properties. This chapter provides a review of fundamental mechanical and electrical properties of dielectric elastomers and up-to-date information regarding new developments of this technology and it’s potential applications for energy harvesting from various vibration sources explored over the past decade.",book:{id:"6509",slug:"energy-harvesting",title:"Energy Harvesting",fullTitle:"Energy Harvesting"},signatures:"Gordon Thomson, Daniil Yurchenko and Dimitri V. Val",authors:[{id:"227338",title:"Ph.D. Student",name:"Gordon",middleName:null,surname:"Thomson",slug:"gordon-thomson",fullName:"Gordon Thomson"},{id:"227344",title:"Dr.",name:"Daniil",middleName:null,surname:"Yurchenko",slug:"daniil-yurchenko",fullName:"Daniil Yurchenko"},{id:"227346",title:"Prof.",name:"Dimitry",middleName:null,surname:"Val",slug:"dimitry-val",fullName:"Dimitry Val"}]}],mostDownloadedChaptersLast30Days:[{id:"61888",title:"Work Function Setting in High-k Metal Gate Devices",slug:"work-function-setting-in-high-k-metal-gate-devices",totalDownloads:2591,totalCrossrefCites:0,totalDimensionsCites:1,abstract:"As transistor size continues to shrink, SiO2/polysilicon gate stack has been replaced by high-k/metal gate to enable further scaling. Two different integration approaches have been implemented in high-volume production: gate first and gate last; the latter is also known as replacement gate approach. In both integration schemes, getting the right work functions and threshold voltages for N-type metal-oxide-semiconductor (NMOS) and P-type metal-oxide-semiconductor (PMOS) devices is critical. A number of recent studies have shown that the threshold voltage of devices is highly dependent on not just the deposited material properties but also on subsequent device processing steps. This chapter contains a description on the different mechanisms of work function setting in gate last and gate first technologies, the sensitivities to different process conditions and special measurement techniques for gate stack analysis is shown.",book:{id:"6511",slug:"complementary-metal-oxide-semiconductor",title:"Complementary Metal Oxide Semiconductor",fullTitle:"Complementary Metal Oxide Semiconductor"},signatures:"Elke Erben, Klaus Hempel and Dina Triyoso",authors:null},{id:"16962",title:"Organic Field-Effect Transistors Using Hetero-Layered Structure with OLED Materials",slug:"organic-field-effect-transistors-using-hetero-layered-structure-with-oled-materials",totalDownloads:6082,totalCrossrefCites:2,totalDimensionsCites:2,abstract:null,book:{id:"253",slug:"organic-light-emitting-diode-material-process-and-devices",title:"Organic Light Emitting Diode",fullTitle:"Organic Light Emitting Diode - Material, Process and Devices"},signatures:"Ken-Ichi Nakayama, Masaaki Yokoyama, Yong-Jin Pu and Junji Kido",authors:[{id:"48743",title:"Prof.",name:"Ken-Ichi",middleName:null,surname:"Nakayama",slug:"ken-ichi-nakayama",fullName:"Ken-Ichi Nakayama"},{id:"94247",title:"Prof.",name:"Masaaki",middleName:null,surname:"Yokoyama",slug:"masaaki-yokoyama",fullName:"Masaaki Yokoyama"},{id:"94248",title:"Prof.",name:"Yong-Jin",middleName:null,surname:"Pu",slug:"yong-jin-pu",fullName:"Yong-Jin Pu"},{id:"94249",title:"Prof.",name:"Junji",middleName:null,surname:"Kido",slug:"junji-kido",fullName:"Junji Kido"}]},{id:"57851",title:"Towards New Generation Power MOSFETs for Automotive Electric Control Units",slug:"towards-new-generation-power-mosfets-for-automotive-electric-control-units",totalDownloads:1472,totalCrossrefCites:1,totalDimensionsCites:0,abstract:"Power metal-oxide-semiconductor field-effect transistors (MOSFETs) are thought to be highly robust and versatile in high-speed switching applications in power electronics design due to its intrinsic high input impedance and compact size. This chapter concerns the development of a high-performance low voltage rating power MOSFET possessing low on-resistance and excellent avalanche current capability for an automotive electric power steering system (EPS). Using industry-standard Technology Computer-Aided Design (TCAD) tools, the planar- and trench-technology power MOSFETs, have been designed, modeled, simulated and compared. We surveyed and analyzed the specific on-resistance due to the different device structures, and various methods are highlighted and compared so that their benefits can be better understood and adopted. Additionally, the device ruggedness has been investigated and its improvement was evaluated and established for that of the trench MOSFET due to gate corner smoothing.",book:{id:"6511",slug:"complementary-metal-oxide-semiconductor",title:"Complementary Metal Oxide Semiconductor",fullTitle:"Complementary Metal Oxide Semiconductor"},signatures:"Kuan W.A. Chee and Tianhong Ye",authors:null},{id:"60757",title:"Selective Epitaxy of Group IV Materials for CMOS Application",slug:"selective-epitaxy-of-group-iv-materials-for-cmos-application",totalDownloads:1820,totalCrossrefCites:0,totalDimensionsCites:1,abstract:"As the International Technology Roadmap for Semiconductors (ITRS) demands an increase of transistor density in the chip, the size of transistors has been continuously shrunk. In this evolution of transistor structure, different strain engineering methods were introduced to induce strain in the channel region. One of the most effective methods is applying embedded SiGe as stressor material in source and drain (S/D) regions by using selective epitaxy. This chapter presents an overview of implementation, modeling, and pattern dependency of selective epitaxy for S/D application in CMOS. The focus is also on the wafer in and ex situ cleaning prior to epitaxy, integrity of gate, and selectivity mode.",book:{id:"6511",slug:"complementary-metal-oxide-semiconductor",title:"Complementary Metal Oxide Semiconductor",fullTitle:"Complementary Metal Oxide Semiconductor"},signatures:"Guilei Wang, Henry H. Radamson and Mohammadreza Kolahdouz",authors:null},{id:"74939",title:"Polyimide in Electronics: Applications and Processability Overview",slug:"polyimide-in-electronics-applications-and-processability-overview",totalDownloads:620,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"Polyimides are nowadays quite famous dielectrics and insulating materials widely used in electronics and electrical engineering applications from low voltage microelectronics up to high voltage engineering industry. They are well appreciated because of their excellent physical properties (i.e., thermal, electrical, and mechanical properties), as well as, their coating process ease either from a liquid or a gas phase. Consequently, polyimides appear in a various range of applications to efficiently separate metal levels or electrodes at different electrical potentials. This chapter intends to review the main chemical generalities of polyimides, the different monomer families, the coating and curing processes, and the main physical properties for electronic and high voltage industrial applications.",book:{id:"7783",slug:"polyimide-for-electronic-and-electrical-engineering-applications",title:"Polyimide for Electronic and Electrical Engineering Applications",fullTitle:"Polyimide for Electronic and Electrical Engineering Applications"},signatures:"Sombel Diaham",authors:[{id:"57115",title:"Dr.",name:"Sombel",middleName:null,surname:"Diaham",slug:"sombel-diaham",fullName:"Sombel Diaham"}]}],onlineFirstChaptersFilter:{topicId:"740",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:32,numberOfPublishedChapters:320,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:133,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:5,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:16,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"24",title:"Sustainable Development",doi:"10.5772/intechopen.100361",issn:null,scope:"
\r\n\tTransforming our World: the 2030 Agenda for Sustainable Development endorsed by United Nations and 193 Member States, came into effect on Jan 1, 2016, to guide decision making and actions to the year 2030 and beyond. Central to this Agenda are 17 Goals, 169 associated targets and over 230 indicators that are reviewed annually. The vision envisaged in the implementation of the SDGs is centered on the five Ps: People, Planet, Prosperity, Peace and Partnership. This call for renewed focused efforts ensure we have a safe and healthy planet for current and future generations.
\r\n
\r\n\t
\r\n
\r\n\tThis Series focuses on covering research and applied research involving the five Ps through the following topics:
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\r\n
\r\n\t1. Sustainable Economy and Fair Society that relates to SDG 1 on No Poverty, SDG 2 on Zero Hunger, SDG 8 on Decent Work and Economic Growth, SDG 10 on Reduced Inequalities, SDG 12 on Responsible Consumption and Production, and SDG 17 Partnership for the Goals
\r\n
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\r\n\t2. Health and Wellbeing focusing on SDG 3 on Good Health and Wellbeing and SDG 6 on Clean Water and Sanitation
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\r\n\t
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\r\n\t3. Inclusivity and Social Equality involving SDG 4 on Quality Education, SDG 5 on Gender Equality, and SDG 16 on Peace, Justice and Strong Institutions
\r\n
\r\n\t
\r\n
\r\n\t4. Climate Change and Environmental Sustainability comprising SDG 13 on Climate Action, SDG 14 on Life Below Water, and SDG 15 on Life on Land
\r\n
\r\n\t
\r\n
\r\n\t5. Urban Planning and Environmental Management embracing SDG 7 on Affordable Clean Energy, SDG 9 on Industry, Innovation and Infrastructure, and SDG 11 on Sustainable Cities and Communities.
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\r\n\tThe series also seeks to support the use of cross cutting SDGs, as many of the goals listed above, targets and indicators are all interconnected to impact our lives and the decisions we make on a daily basis, making them impossible to tie to a single topic.
",coverUrl:"https://cdn.intechopen.com/series/covers/24.jpg",latestPublicationDate:"July 5th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:0,editor:{id:"262440",title:"Prof.",name:"Usha",middleName:null,surname:"Iyer-Raniga",slug:"usha-iyer-raniga",fullName:"Usha Iyer-Raniga",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRYSXQA4/Profile_Picture_2022-02-28T13:55:36.jpeg",biography:"Usha Iyer-Raniga is a professor in the School of Property and Construction Management at RMIT University. Usha co-leads the One Planet Network’s Sustainable Buildings and Construction Programme (SBC), a United Nations 10 Year Framework of Programmes on Sustainable Consumption and Production (UN 10FYP SCP) aligned with Sustainable Development Goal 12. The work also directly impacts SDG 11 on Sustainable Cities and Communities. She completed her undergraduate degree as an architect before obtaining her Masters degree from Canada and her Doctorate in Australia. Usha has been a keynote speaker as well as an invited speaker at national and international conferences, seminars and workshops. Her teaching experience includes teaching in Asian countries. She has advised Austrade, APEC, national, state and local governments. She serves as a reviewer and a member of the scientific committee for national and international refereed journals and refereed conferences. She is on the editorial board for refereed journals and has worked on Special Issues. Usha has served and continues to serve on the Boards of several not-for-profit organisations and she has also served as panel judge for a number of awards including the Premiers Sustainability Award in Victoria and the International Green Gown Awards. Usha has published over 100 publications, including research and consulting reports. Her publications cover a wide range of scientific and technical research publications that include edited books, book chapters, refereed journals, refereed conference papers and reports for local, state and federal government clients. She has also produced podcasts for various organisations and participated in media interviews. She has received state, national and international funding worth over USD $25 million. Usha has been awarded the Quarterly Franklin Membership by London Journals Press (UK). Her biography has been included in the Marquis Who's Who in the World® 2018, 2016 (33rd Edition), along with approximately 55,000 of the most accomplished men and women from around the world, including luminaries as U.N. Secretary-General Ban Ki-moon. In 2017, Usha was awarded the Marquis Who’s Who Lifetime Achiever Award.",institutionString:null,institution:{name:"RMIT University",institutionURL:null,country:{name:"Australia"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:5,paginationItems:[{id:"91",title:"Sustainable Economy and Fair Society",coverUrl:"https://cdn.intechopen.com/series_topics/covers/91.jpg",isOpenForSubmission:!0,annualVolume:11975,editor:{id:"181603",title:"Dr.",name:"Antonella",middleName:null,surname:"Petrillo",slug:"antonella-petrillo",fullName:"Antonella Petrillo",profilePictureURL:"https://mts.intechopen.com/storage/users/181603/images/system/181603.jpg",biography:"Antonella Petrillo is a Professor at the Department of Engineering of the University of Naples “Parthenope”, Italy. She received her Ph.D. in Mechanical Engineering from the University of Cassino. Her research interests include multi-criteria decision analysis, industrial plant, logistics, manufacturing and safety. She serves as an Associate Editor for the International Journal of the Analytic Hierarchy Process. She is a member of AHP Academy and a member of several editorial boards. She has over 160 Scientific Publications in International Journals and Conferences and she is the author of 5 books on Innovation and Decision Making in Industrial Applications and Engineering.",institutionString:null,institution:{name:"Parthenope University of Naples",institutionURL:null,country:{name:"Italy"}}},editorTwo:null,editorThree:null},{id:"92",title:"Health and Wellbeing",coverUrl:"https://cdn.intechopen.com/series_topics/covers/92.jpg",isOpenForSubmission:!0,annualVolume:11976,editor:{id:"348225",title:"Prof.",name:"Ann",middleName:null,surname:"Hemingway",slug:"ann-hemingway",fullName:"Ann Hemingway",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035LZFoQAO/Profile_Picture_2022-04-11T14:55:40.jpg",biography:"Professor Hemingway is a public health researcher, Bournemouth University, undertaking international and UK research focused on reducing inequalities in health outcomes for marginalised and excluded populations and more recently focused on equine assisted interventions.",institutionString:null,institution:{name:"Bournemouth University",institutionURL:null,country:{name:"United Kingdom"}}},editorTwo:null,editorThree:null},{id:"93",title:"Inclusivity and Social Equity",coverUrl:"https://cdn.intechopen.com/series_topics/covers/93.jpg",isOpenForSubmission:!0,annualVolume:11977,editor:{id:"210060",title:"Prof. Dr.",name:"Ebba",middleName:null,surname:"Ossiannilsson",slug:"ebba-ossiannilsson",fullName:"Ebba Ossiannilsson",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6LkBQAU/Profile_Picture_2022-02-28T13:31:48.png",biography:"Professor Dr. Ebba Ossiannilsson is an independent researcher, expert, consultant, quality auditor and influencer in the fields of open, flexible online and distance learning (OFDL) and the 'new normal'. Her focus is on quality, innovation, leadership, and personalised learning. She works primarily at the strategic and policy levels, both nationally and internationally, and with key international organisations. She is committed to promoting and improving OFDL in the context of SDG4 and the future of education. Ossiannilsson has more than 20 years of experience in her current field, but more than 40 years in the education sector. She works as a reviewer and expert for the European Commission and collaborates with the Joint Research Centre for Quality in Open Education. Ossiannilsson also collaborates with ITCILO and ICoBC (International Council on Badges and Credentials). She is a member of the ICDE Board of Directors and has previously served on the boards of EDEN and EUCEN. Ossiannilsson is a quality expert and reviewer for ICDE, EDEN and the EADTU. She chairs the ICDE OER Advocacy Committee and is a member of the ICDE Quality Network. She is regularly invited as a keynote speaker at conferences. She is a guest editor for several special issues and a member of the editorial board of several scientific journals. She has published more than 200 articles and is currently working on book projects in the field of OFDL. Ossiannilsson is a visiting professor at several international universities and was recently appointed Professor and Research Fellow at Victoria University of Wellington, NZ. Ossiannilsson has been awarded the following fellowships: EDEN Fellows, EDEN Council of Fellows, and Open Education Europe. She is a ICDE OER Ambassador, Open Education Europe Ambassador, GIZ Ambassador for Quality in Digital Learning, and part of the Globe-Community of Digital Learning and Champion of SPARC Europe. On a national level, she is a quality developer at the Swedish Institute for Standards (SIS) and for ISO. She is a member of the Digital Skills and Jobs Coalition Sweden and Vice President of the Swedish Association for Distance Education. She is currently working on a government initiative on quality in distance education at the National Council for Higher Education. She holds a Ph.D. from the University of Oulu, Finland.",institutionString:"Swedish Association for Distance Education, Sweden",institution:null},editorTwo:null,editorThree:null},{id:"94",title:"Climate Change and Environmental Sustainability",coverUrl:"https://cdn.intechopen.com/series_topics/covers/94.jpg",isOpenForSubmission:!0,annualVolume:11978,editor:{id:"61855",title:"Dr.",name:"Yixin",middleName:null,surname:"Zhang",slug:"yixin-zhang",fullName:"Yixin Zhang",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYWJgQAO/Profile_Picture_2022-06-09T11:36:35.jpg",biography:"Professor Yixin Zhang is an aquatic ecologist with over 30 years of research and teaching experience in three continents (Asia, Europe, and North America) in Stream Ecology, Riparian Ecology, Urban Ecology, and Ecosystem Restoration and Aquatic Conservation, Human-Nature Interactions and Sustainability, Urbanization Impact on Aquatic Ecosystems. He got his Ph.D. in Animal Ecology at Umeå University in Sweden in 1998. He conducted postdoc research in stream ecology at the University of California at Santa Barbara in the USA. After that, he was a postdoc research fellow at the University of British Columbia in Canada to do research on large-scale stream experimental manipulation and watershed ecological survey in temperate rainforests of BC. He was a faculty member at the University of Hong Kong to run ecological research projects on aquatic insects, fishes, and newts in Tropical Asian streams. He also conducted research in streams, rivers, and caves in Texas, USA, to study the ecology of macroinvertebrates, big-claw river shrimp, fish, turtles, and bats. Current research interests include trophic flows across ecosystems; watershed impacts of land-use change on biodiversity and ecosystem functioning; ecological civilization and water resource management; urban ecology and urban/rural sustainable development.",institutionString:null,institution:{name:"Soochow University",institutionURL:null,country:{name:"China"}}},editorTwo:null,editorThree:null},{id:"95",title:"Urban Planning and Environmental Management",coverUrl:"https://cdn.intechopen.com/series_topics/covers/95.jpg",isOpenForSubmission:!0,annualVolume:11979,editor:{id:"181079",title:"Dr.",name:"Christoph",middleName:null,surname:"Lüthi",slug:"christoph-luthi",fullName:"Christoph Lüthi",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRHSqQAO/Profile_Picture_2022-04-12T15:51:33.png",biography:"Dr. Christoph Lüthi is an urban infrastructure planner with over 25 years of experience in planning and design of urban infrastructure in middle and low-income countries. He holds a Master’s Degree in Urban Development Planning from the University College of London (UCL), and a Ph.D. in Urban Planning & Engineering from TU Berlin. He has conducted applied research on urban planning and infrastructure issues in over 20 countries in Africa and Asia. In 2005 he joined Eawag-Sandec as Leader of the Strategic Environmental Sanitation Planning Group. 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\r\n\tIf we aim to prosper as a society and as a species, there is no alternative to sustainability-oriented development and growth. Sustainable development is no longer a choice but a necessity for us all. Ecosystems and preserving ecosystem services and inclusive urban development present promising solutions to environmental problems. Contextually, the emphasis on studying these fields will enable us to identify and define the critical factors for territorial success in the upcoming decades to be considered by the main-actors, decision and policy makers, technicians, and public in general.
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\r\n\tHolistic urban planning and environmental management are therefore crucial spheres that will define sustainable trajectories for our urbanizing planet. This urban and environmental planning topic aims to attract contributions that address sustainable urban development challenges and solutions, including integrated urban water management, planning for the urban circular economy, monitoring of risks, contingency planning and response to disasters, among several other challenges and solutions.
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Dr. Şentürk currently works as an professor of Biochemistry in the Department of Basic Pharmacy Sciences, Faculty of Pharmacy, Ağri Ibrahim Cecen University, Turkey. \nDr. Şentürk published over 120 scientific papers, reviews, and book chapters and presented several conferences to scientists. \nHis research interests span enzyme inhibitor or activator, protein expression, purification and characterization, drug design and synthesis, toxicology, and pharmacology. \nHis research work has focused on neurodegenerative diseases and cancer treatment. 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Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. This Biochemistry Series will address the current research on biomolecules and the emerging trends with great promise.",coverUrl:"https://cdn.intechopen.com/series/covers/11.jpg",latestPublicationDate:"July 5th, 2022",hasOnlineFirst:!0,numberOfOpenTopics:4,numberOfPublishedChapters:319,numberOfPublishedBooks:32,editor:{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},subseries:[{id:"14",title:"Cell and Molecular Biology",keywords:"Omics (Transcriptomics; Proteomics; Metabolomics), Molecular Biology, Cell Biology, Signal Transduction and Regulation, Cell Growth and Differentiation, Apoptosis, Necroptosis, Ferroptosis, Autophagy, Cell Cycle, Macromolecules and Complexes, Gene Expression",scope:"The Cell and Molecular Biology topic within the IntechOpen Biochemistry Series aims to rapidly publish contributions on all aspects of cell and molecular biology, including aspects related to biochemical and genetic research (not only in humans but all living beings). We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics include, but are not limited to: Advanced techniques of cellular and molecular biology (Molecular methodologies, imaging techniques, and bioinformatics); Biological activities at the molecular level; Biological processes of cell functions, cell division, senescence, maintenance, and cell death; Biomolecules interactions; Cancer; Cell biology; Chemical biology; Computational biology; Cytochemistry; Developmental biology; Disease mechanisms and therapeutics; DNA, and RNA metabolism; Gene functions, genetics, and genomics; Genetics; Immunology; Medical microbiology; Molecular biology; Molecular genetics; Molecular processes of cell and organelle dynamics; Neuroscience; Protein biosynthesis, degradation, and functions; Regulation of molecular interactions in a cell; Signalling networks and system biology; Structural biology; Virology and microbiology.",annualVolume:11410,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"79367",title:"Dr.",name:"Ana Isabel",middleName:null,surname:"Flores",fullName:"Ana Isabel Flores",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRpIOQA0/Profile_Picture_1632418099564",institutionString:null,institution:{name:"Hospital Universitario 12 De Octubre",institutionURL:null,country:{name:"Spain"}}},{id:"328234",title:"Ph.D.",name:"Christian",middleName:null,surname:"Palavecino",fullName:"Christian Palavecino",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000030DhEhQAK/Profile_Picture_1628835318625",institutionString:null,institution:{name:"Central University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"186585",title:"Dr.",name:"Francisco Javier",middleName:null,surname:"Martin-Romero",fullName:"Francisco Javier Martin-Romero",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSB3HQAW/Profile_Picture_1631258137641",institutionString:null,institution:{name:"University of Extremadura",institutionURL:null,country:{name:"Spain"}}}]},{id:"15",title:"Chemical Biology",keywords:"Phenolic Compounds, Essential Oils, Modification of Biomolecules, Glycobiology, Combinatorial Chemistry, Therapeutic peptides, Enzyme Inhibitors",scope:"Chemical biology spans the fields of chemistry and biology involving the application of biological and chemical molecules and techniques. In recent years, the application of chemistry to biological molecules has gained significant interest in medicinal and pharmacological studies. This topic will be devoted to understanding the interplay between biomolecules and chemical compounds, their structure and function, and their potential applications in related fields. Being a part of the biochemistry discipline, the ideas and concepts that have emerged from Chemical Biology have affected other related areas. This topic will closely deal with all emerging trends in this discipline.",annualVolume:11411,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null,editorialBoard:[{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",fullName:"Abdulsamed Kükürt",profilePictureURL:"https://mts.intechopen.com/storage/users/219081/images/system/219081.png",institutionString:null,institution:{name:"Kafkas University",institutionURL:null,country:{name:"Turkey"}}},{id:"241413",title:"Dr.",name:"Azhar",middleName:null,surname:"Rasul",fullName:"Azhar Rasul",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRT1oQAG/Profile_Picture_1635251978933",institutionString:null,institution:{name:"Government College University, Faisalabad",institutionURL:null,country:{name:"Pakistan"}}},{id:"178316",title:"Ph.D.",name:"Sergey",middleName:null,surname:"Sedykh",fullName:"Sergey Sedykh",profilePictureURL:"https://mts.intechopen.com/storage/users/178316/images/system/178316.jfif",institutionString:null,institution:{name:"Novosibirsk State University",institutionURL:null,country:{name:"Russia"}}}]},{id:"17",title:"Metabolism",keywords:"Biomolecules Metabolism, Energy Metabolism, Metabolic Pathways, Key Metabolic Enzymes, Metabolic Adaptation",scope:"Metabolism is frequently defined in biochemistry textbooks as the overall process that allows living systems to acquire and use the free energy they need for their vital functions or the chemical processes that occur within a living organism to maintain life. Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. Thus all studies on metabolism will be considered for publication.",annualVolume:11413,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",fullName:"Anca Pantea Stoian",profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"203824",title:"Dr.",name:"Attilio",middleName:null,surname:"Rigotti",fullName:"Attilio Rigotti",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institutionString:null,institution:{name:"Pontifical Catholic University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"300470",title:"Dr.",name:"Yanfei (Jacob)",middleName:null,surname:"Qi",fullName:"Yanfei (Jacob) Qi",profilePictureURL:"https://mts.intechopen.com/storage/users/300470/images/system/300470.jpg",institutionString:null,institution:{name:"Centenary Institute of Cancer Medicine and Cell Biology",institutionURL:null,country:{name:"Australia"}}}]},{id:"18",title:"Proteomics",keywords:"Mono- and Two-Dimensional Gel Electrophoresis (1-and 2-DE), Liquid Chromatography (LC), Mass Spectrometry/Tandem Mass Spectrometry (MS; MS/MS), Proteins",scope:"With the recognition that the human genome cannot provide answers to the etiology of a disorder, changes in the proteins expressed by a genome became a focus in research. Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. The Proteomics topic aims to attract contributions on all aspects of MS-based proteomics that, by pushing the boundaries of MS capabilities, may address biological problems that have not been resolved yet.",annualVolume:11414,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null,editorialBoard:[{id:"72288",title:"Dr.",name:"Arli Aditya",middleName:null,surname:"Parikesit",fullName:"Arli Aditya Parikesit",profilePictureURL:"https://mts.intechopen.com/storage/users/72288/images/system/72288.jpg",institutionString:null,institution:{name:"Indonesia International Institute for Life Sciences",institutionURL:null,country:{name:"Indonesia"}}},{id:"40928",title:"Dr.",name:"Cesar",middleName:null,surname:"Lopez-Camarillo",fullName:"Cesar Lopez-Camarillo",profilePictureURL:"https://mts.intechopen.com/storage/users/40928/images/3884_n.png",institutionString:null,institution:{name:"Universidad Autónoma de la Ciudad de México",institutionURL:null,country:{name:"Mexico"}}},{id:"81926",title:"Dr.",name:"Shymaa",middleName:null,surname:"Enany",fullName:"Shymaa Enany",profilePictureURL:"https://mts.intechopen.com/storage/users/81926/images/system/81926.png",institutionString:"Suez Canal University",institution:{name:"Suez Canal University",institutionURL:null,country:{name:"Egypt"}}}]}]}},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"chapter.detail",path:"/chapters/57069",hash:"",query:{},params:{id:"57069"},fullPath:"/chapters/57069",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()