\r\n\tThis book chapter’s main theme will be focused on transmission dynamics, pathogenesis, mechanisms of host interaction and response, epigenetics and markers, molecular diagnosis, RNA interacting proteins, RNA binding proteins, advanced development of tools for diagnosis, possible development of concepts for vaccines and anti drugs for RNA viruses, immunological mechanisms, treatment, prevention and control. \r\n\t
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1. Introduction
Muchof the previous research on internationalisation behaviour concludes that firms become involved in international markets gradually [1]. However, in the last 20 years, a new kind of business has emerged that does not follow a gradual internationalisation pattern, but is characterised by rapid commitment to international activity. Oviatt and Dougall [2] called these businesses ‘Born Globals’ (BGs), and they have given rise to a new line of research known as international entrepreneurship centred on the study of how new ventures are committed to developing the processes of ‘discovery, enactment, evaluation, and exploitation of opportunities across national borders to create future goods and services’ ([3], p.7). Past research in this area has centred on determining the factors that might explain the exceptional speed with which certain new ventures can internationalise [3–10]. However, several authors consider that to be able to advance our understanding of BGs, we need to analyse the factors that can affect their competitiveness after their creation, particularly from a marketing perspective [11–17].
Traditionally, lack of market knowledge has been regarded as one of the biggest impediments small businesses have to overcome in their internationalisation process [18–20] in that it constitutes a key variable for proactively seeking international opportunities [21, 22]. McNaugthon [23] shows that companies concerned to expand their knowledge of foreign markets have a broader perspective and there is a greater chance that they will seize the opportunities that appear in them.
If we attempt to identify the main source of this knowledge, we observe that traditional gradualist models attribute a fundamental role in knowledge generation—and, therefore, in the internationalisation process—to the firm’s experience (at home and abroad) [1]. However, in the case of BGs, knowledge based on experience cannot be considered the only source of knowledge about foreign markets that these firms use, as their experience is minimal. For this reason, it becomes necessary to investigate how BGs manage to acquire and interpret information about markets and how they translate it into specific actions that affect the development of skills that help them to remain dynamic in international markets [22, 24, 25].
Many marketing scholars argue that market orientation plays a determining role in the international success of new businesses due to its contribution to effective knowledge management [26–30]. In this line, Knight and Cavusgil [31] point out that the market orientation of new international ventures enhances their understanding of their customers’ present and future needs and optimises the development of distinctive actions that can meet these needs by providing a more valuable offer than that of their rivals.
In addition, based on the social perspective, the study of entrepreneurship has also highlighted the importance of the links entrepreneurs develop with members of their networks as they facilitate rapid access to the information and knowledge associated with the latest trends in the new markets, and with certain key resources that are not initially available to these firms [32–36].
However, although from the theoretical viewpoint there seems to be a strong complementarity between market orientation and membership of business networks, as shown in certain studies [13, 37, 38], little is known about the way these factors combine. In this vein, Loane and Bell [18] highlight the need for research attention to the mechanisms and routines that enable new international ventures to generate and manage knowledge through relationships they establish in networks. In turn, Evanschitzky [38] highlights the importance of studying their influence on competitiveness and firm performance, in light of the scarce knowledge to date.
In this respect, this study covers the mutually complementary nature of both factors in a single construct known as network market orientation (NMO). Thus, although previous studies have emphasised the importance of MO in the context of relationships between firms, they have not analysed it as an inter-business phenomenon in itself, but rather as the sum of the market orientations of the various individual firms [22, 37, 39, 40]. The present work analyses the role of NMO differently, understanding it as an orientation established jointly by the different members making up the network.
However, the effect of any organisational factor is usually subject to significant causal ambiguity regarding the way firms maintain their capacity to use the knowledge generated in order to continue seizing the market opportunities that arise [41]. Adopting an NMO that promotes a cognitive effort and collective approach to learning can help to overcome this ambiguity by improving understanding of the new and changing links between action and performance and, in this way, recognising the need to face changes in existing routines [22, 40, 42, 43]. In line with this idea, it is essential that BGs complement their adoption of an NMO with the generation of dynamic absorptive capability in order to ensure continuing commitment to construct new resources and capabilities and reconfigure existing ones, thereby adapting to new market demands [22, 44–48].
Specifically, this absorptive capability is related to the assimilation of external information into the firm’s internal knowledge base [4, 49]. It is crucial for each firm to develop this capability individually, since it enables the external knowledge generated in the network context to be perfectly understood and assimilated internally by the firm and put to use successfully [50–54].
Ultimately, this study aims to contribute to the existing literature by analysing the way in which BGs start by adopting an NMO in order to access and systematically manage information from foreign markets and the way this orientation contributes to generating a dynamic absorptive capability that helps them to capitalise on the knowledge generated, thus facilitating their consolidation abroad.
In order to meet this objective, we first present the theoretical frame used to formulate hypotheses on the influence of NMO on BGs’ international competitiveness and performance. The empirical study carried out to test the hypotheses is then reported, with an analysis of the results obtained and the main conclusions. Finally, limitations and future research lines associated with this study are described.
2. Theoretical development
2.1. The relevance of NMO for BGs
The international entrepreneurship literature has increasingly emphasised the role of business networks in the process of learning and knowledge generation in BGs [36, 55–57]. The relationships an entrepreneur builds with the other network members (family members, customers, distributorsand providers) can be crucial in (1) generating more differential and valuable knowledge on new clients’ needs and the business environment conditions, (2) knowing how to exploit the positive conditions and avoid the negative ones and (3) accessing the capabilities and resources required to do it [34]. Networks, therefore, offer BGs a way of compensating for their limitations of newness [58], smallness [59] and foreignness [60] by providing the opportunity to access valuable supplementary knowledge on aspects such as technology, distribution channels and customer bases [61] and to improve other knowledge-related aspects such as information exchange and coordination [62] and the speed of know-how and technology transfer [63]. Thus, networks are key for BGs to develop a broader knowledge base beyond what they could achieve alone [64], abandoning the idea that the generation of new knowledge is a purely internal process [19, 25, 56, 65]. This is particularly so if we bear in mind that BGs are characterised by their lack of necessary resources.
The processes that contribute to relational information management in adopting an NMO are presented in the theoretical proposal of Helfert et al. [37]. These authors define four relational knowledge management mechanisms developed jointly by the members of a network: knowledge exchange processes, in order to satisfy clients’ requirements; coordination processes, aimed at synchronising the network ties through formal and informal routines; coupling processes, necessary to adapt the particular features of a network member and conflict resolution mechanisms designed to solve unexpected contexts. The work of Helfert et al. [37] represents a significant step forward in the study of this construct. In fact, previous research was limited to considering the sum of market orientations in individual companies [66] or adapting the original market orientation models (behavioural and cultural) to the network setting.
Following the work of Helfert et al. [37], Monferrer et al. [22:p.388] defined NMO as ‘a strategic orientation established jointly by the different members in the business relations network. This strategic orientation involves, in a climate of trust, collaboration and commitment, engaging in certain activities and fundamental shared behaviours (adaptation, coordination, conflict resolution and exchange) based on the generation of an extended intellectual capital’. These activities seek to increase the competitiveness of the network and its individual members in an attempt to provide superior value to end customers by satisfying their needs.
2.2. NMO and absorptive capability in BGs
Absorptive dynamic capability is related to the processes developed in the company to seek new information, internalise it and integrate it into the firm’s existing knowledge base [49]. Developing this capability is vitally important for BGs’ survival, since their business opportunity has not yet been consolidated. Furthermore, given that BGs compete in a global market segment [2, 3], the nature of the factors that influence the conditions of their business environment come from a greater diversity of sources. This variety of sources has the effect of increasing the complexity associated with the mechanisms BGs need to generate in order to manage and internally integrate knowledge from their external markets. For this reason, before developing new knowledge search and integrative mechanisms, firms must stimulate the use of processes that allow original knowledge from different sources to be managed efficiently [22, 48].
BGs are recently created companies and therefore they assume limited resource availability [5, 6, 8, 14, 17, 67]. In these circumstances, networks facilitate the development of absorptive capability in BGs [68]. Nahapiet and Ghoshal [69] indicate that to access the different sources of knowledge from their external markets, firms need to generate communication processes in order to guarantee the capture and integration of real and potential capabilities and resources associated to the relationships an individual unit builds through its network. Similarly, Cohen and Levinthal [49] suggest that absorptive capability is built on communication structures that cross firm boundaries.
Belonging to a market-oriented network will therefore give BGs some relevant advantages, first by improving their capacity to develop an agreed perception of their markets based on multiple agents and sources of knowledge; and second, by incorporating coordination processes to interpret and understand that knowledge and integrate it into the internal firm’s knowledge base [22, 37, 40]. In sum, a market-oriented network facilitates the development of BGs’ absorptive capability. We therefore posit that:
H1: Participation of BGs in market-oriented networks stimulates their absorptive capability.
2.3. Absorptive capability and competitive advantages in BGs
To specify these competitive advantages, we are guided by the work of Porter [70], who considers that the different meanings used to refer to competitive advantages can be condensed into two general ones which cover all the rest [13, 71–73]: product differentiation-based and cost-based competitive advantages. The former refers to factors such as quality, design and other attributes that distinguish firms’ offers of value from those of their rivals [70–72], as well as advantages linked to services such as delivery speed, reliability and managing additional services [40, 72, 73]. In turn, cost-based advantages lie in the domain of manufacturing, administration and commercialisation costs. They give the producer value in the form of lower costs and offer the consumer the lowest price [40, 70, 72, 73].
Regarding the influence that absorptive capability has on these advantages, Cohen and Levinthal [49] argue that establishing practices which encourage the assimilation of external knowledge creates a positive incentive to invest in R&D and thus improve the firm’s possibilities of achieving superior competitive advantages. According to Ref. [74], improving the differential nature of a new company requires (1) the internal application of certain valuable knowledge-based resources and capabilities; (2) the skill to associate them with other external ones; (3) the capacity to integrate the knowledge derived from this association internally and (4) the capability to apply this knowledge to potentially successful business aims. As Laursen and Salter ([75], p.146) manifest ‘the lack of openness of firms to their external environment may reflect an organizational myopia, indicating that managers may overemphasize internal sources and under emphasize external sources’. An excessively internal vision may therefore negatively influence the competitiveness of the firm [49]. To encourage firm competitiveness, ideally there should be a balance between the concentration of internal capabilities and openness to the exterior [76]. In this regard, Vinding [77] extols the role of absorptive capability, as it enables the firm’s internal capability and its external collaboration to complement each other. On the basis of this capability firms manage to capture, absorb and use external knowledge, thereby facilitating the achievement of competitive advantages [22, 78–80].
BGs tend to gradually define the specifications of their products or services by taking into account the particularities of their customers and the conditions that characterise their competitive environment [22]. BGs thus need to avoid internal short-sightedness when specifying market trends in differential and low cost products or services [3, 22, 81]. Therefore, BGs use the information and knowledge generated on the basis of their absorptive capability to introduce the valuable specifications and features required in their products or services to guarantee the feasibility of their business project. These arguments lead us to propose that:
H2: Greater absorptive capability in BGs leads to greater development of differentiation-based competitive advantages.
H3: Greater absorptive capability in BGs leads to greater development of cost-based competitive advantages.
2.4. Competitive advantages and international performance in BGs
A review of the conceptualisations of the competitive advantage concept shows that, by definition, a firm has a competitive advantage over another firm when it obtains a superior performance [82]. Therefore, the competitive advantage can be seen as a direct antecedent of a BG’s international performance because the superiority arising from its attempt to provide value determines the purchasing performance of its target market [55], and consequently its performance [40, 72, 83]. When a firm achieves competitive advantages (differentiation-based and/or cost-based), it has a higher capacity to generate value for its clients and, in turn, greater levels of client satisfaction, business volume and market share and lower customer service costs [30, 84, 85]. As Snoj et al. [83] point out, sustaining competitive advantages is the basis for achieving superior business performance, survival and development. Therefore, the following hypotheses are proposed:
H4: BGs’ achievement of differentiation-based competitive advantages contributes to higher levels of international performance.
H5. BGs’ achievement of cost-based competitive advantages contributes to higher levels of international performance.
Figure 1 summarises the model of effects for the study.
Figure 1.
Model of effects.
3. Methodology
3.1. Sample selection and data collection
We started with 2012 Spanish firms, all under 7 years old and operating internationally, taken from the Dun and Bradstreet and SABI databases. To refine the sample and ensure that the firms selected were BGs, a total of six selection criteria were applied on two different occasions: prior to and during the field study. Thus, based on the filters available in the databases, the following criteria were applied: (1) the firms should be no more than 7 years old, thus guaranteeing that they are new firms; (2) they should make their own strategic decisions, thus excluding subsidiary or affiliated firms; (3) they should have a minimum of three employees and a maximum of 250, ruling out micro-firms, self-employed individuals and big firms. This process of refinement resulted in a population of 1023 firms.
The questionnaire was drawn up, based on an in-depth bibliographical review, including the three remaining selection criteria (not available without direct consultation with the firm): (4) their international activity should have started in the first three years following their creation, thus showing their immediate incorporation into foreign markets; (5) they should generate a minimum of 25% of their annual sales abroad, thus providing evidence of a consolidated international presence and (6) they should form a part of a network of firms with a minimum of three members. Regarding this last criterion, in order to ensure that interviewees focused their responses on their main business network, as an introduction the following definition was included, in which business networks are understood as ‘the set of relationships that the firm maintains with other agents such as customers, suppliers, competitors, consultants, government agencies, universities, research centres, market research firms, advertising agencies and sales or distribution agents with the aim of obtaining knowledge, information, technology, resources or skills’ ([86], p.24).
The questionnaire was then pre-tested with a pilot sample of 25 firms to ensure it would be correctly understood. An electronic version was then prepared for the field work, of which 303 valid responses were returned (29.62% of the total).
An analysis of the primary data revealed the principal characteristics of the sample (Table 1). The firms are SMEs, mostly from the industrial sector (61.2% of the total), notably the agrifood, metal and textile sectors. Commerce is represented by 31.6%, including firms that export and import products related to the aforementioned industrial sectors. Finally, less than 7.2% of firms come from the services sector, including mostly financial, tourism and communication agencies. The firms have on average 28.55 employees, 41.50% of their commercialisation work is abroad, and their average age is 3.90 years.
Figures expressed as a percentage of total responses.
Note:
Regarding the networks to which the firms belong (Table 2), almost all of them became part of the network on their creation (96.4% after their first year of life), they are usually networks with marketing aims (in 92.5% of cases) and are composed on average of 5.81 firms, located near the firm (62.19% of the networks have a regional scope).
General characteristics of the main networks of the studied firms.
According to the location of most network members.
3.2. Measurement instruments
To measure the market orientation of the network we adapted the scale proposed by Helfert et al. [37]. These authors move away from the idea defended in previous studies of measuring the network’s market orientation by simply adapting the dimensions used in the seminal scales of MO. Specifically, this scale includes a total of 12 items on the four dimensions that reflect the relational processes management of NMO: coupling (2 items), coordination (3 items), conflict resolution (3 items) and exchange (4 items).
To measure absorptive capability, we use the three-item scale of Ref. [87] that evaluates the degree to which the firm’s management systems encourage the ability to acquire, assimilate, transform and exploit knowledge.
Competitive advantages are measured with the scale developed by Ling-Yee and Ogunmokun [71] and the proposals made by Morgan et al. [72] and Ha-Brookshire and Dyer [73]. This scale reflects the firm’s position in relation to competition in terms of differentiation and costs when adapting its offer to international market needs.
Finally, we use an adaptation of the scale proposed by Jantunen et al. [81] to measure international performance. Specifically, we asked BG managers about their degree of satisfaction with their activity in terms of turnover, profitability, market share and global satisfaction.
3.3. Validity and scale reliability
To refine the scales, a confirmatory factor analysis was performed using structural equations models. The analyses guarantee a measurement model consistent with the theoretical proposals, supported by scales that are reliable, valid and present a certain degree of unidimensionality.
Based on the recommendations of Jöreskog and Söbom [88], we first examined the estimation parameters. We removed those indicators with standardised coefficients (λ) under 0.7, significance of the Student t statistic under 2.58 (P=0.01) and R2 under 0.49, thus ensuring that the strong and weak convergence conditions were met [89]. This process led to the removal of the indicators EXCH.3 from the NMO scale, ABS.1 from the absorption capability scale, and CACOS.3, CADIF.3 and CADIF.4 from the competitive advantages based on costs and differentiation, respectively. Several tests were then performed to verify whether or not the process of refinement of the scales had altered their level of reliability. We used Cronbach’s alpha [90] to analyse internal consistency. Other complementary tests of reliability were carried out: the composite reliability of the construct and the analysis of the average variance extracted (see Table 3).
Scale
1st order
2nd order
PERF
ABS
CACOS
CADIF
COUP
COOR
CONF
EXCH
NMO
λ
0.74–0.87
0.72–0.84
0.85–0.86
0.71–0.82
0.81–0.91
0.73–0.90
0.77–0.91
0.72–0.87
0.76–0.95
α
0.887
0.749
0.841
0.732
0.845
0.871
0.887
0.847
NP
CR
0.887
0.753
0.842
0.738
0.850
0.876
0.891
0.857
0.915
AVE
0.612
0.606
0.727
0.586
0.741
0.704
0.732
0.667
0.731
Significant loads
All t > 2.58
R2
All R2 > 0.49
χ2/df
RMSEA
SRMR
GFI
AGFI
NFI
NNFI
IFI
CFI
1.726
0.049
0.050
0.894
0.864
0.901
0.947
0.956
0.955
Table 3.
Summary of the results after the definitive factor analysis.
Finally, the convergent and discriminant validity were analysed. With reference to the former, it was sufficient to observe that the estimated value of the correlations between the dimensions configuring the scales was high and significant. The confidence interval test was performed to examine discriminant validity, verifying that ‘1’ was not found in the intervals estimated for the correlations between each pair of dimensions (Table 4). The measurement model proposed is therefore reliable and valid for use in the testing of hypotheses.
Pair of variables
CACOS-ABS
CACOS-CADIF
CACOS-NMO
ABS-CADIF
ABS-NMO
I.C.
[0.143; 0.415]
[0.145; 0.421]
[0.124; 0.376]
[0.148; 0.436]
[0.198; 0.454]
Pair of variables
CADIF-NMO
CACOS-PERF
ABS-PERF
CADIF-PERF
NMO-PERF
I.C.
[0.036; 0.312]
[0.117; 0.369]
[0.049; 0.321]
[0.154; 0.418]
[0.279; 0.503]
Table 4.
Discriminant validity analysis using the confidence interval (CI) test.
Further tests were also carried out. First, we checked for signs of multicollinearity by testing the variance inflation factor (VIF) among latent variables in our proposed overall model. Values were below 10 [91], suggesting multicollinearity was not an issue in our study. Second, a t-test of independent means was performed on the dimensions of the variables in the proposed model. This test was conducted using the first 45 and last 45 respondents. No significant differences were found between these respondents at the 0.05 level, indicating an absence of non-response bias [92]. Third, various ANOVA were run to confirm that sample characteristics do not affect the model constructs. The following control variables were used, based on the data gathered in the questionnaire: sector of activity, international consolidation, age, international seniority, size, seniority in the network (all firm-related variables) and size of the network. Results revealed no significant differences in any of the analyses. Finally, the possibility of common method variance bias was tested with Harman’s test, concluding that the bias caused by the method used was not a problem for the validity of the results obtained in the subsequent testing of the hypotheses [93, 94].
4. Results
Research in business-related sciences has gradually been enriched by the introduction of more sophisticated methodologies. This greater degree of development has enabled researchers to design and test increasingly complex models addressed to explaining the business reality.
Structural equations models have emerged from the evolution of multi-equation modelling developed chiefly in econometrics and combined with the principles of measurement from psychology and sociology, aimed at overcoming the limitation shared by other multivariate techniques such as multiple regression, factor analysis, multivariate analysis of variance or discriminant analysis, all of which can examine just one relation at a time [91]. Unlike the above-mentioned techniques, a structural equations model (SEM)-based analysis is able to explore a series of dependent relations simultaneously [91]. Therefore, this technique is particularly useful when a dependent variable becomes an independent variable in subsequent dependency relations.
For this reason, as with the scale validation, SEM was used to test the hypotheses, since they have proved to be highly useful in a non-experimental situation when the study aims to uncover the causal influence from one factor to another [88].
The hypotheses that constitute the model of effects were tested using EQS 6.1 software. Table 5 shows that none of the proposed hypotheses were refuted. First, as expected, NMO presented a positive and significant effect on BGs’ absorptive capability (H1: λ = 0.355; t = 4.931). Moreover, BGs’ absorptive capability turned out to be a key variable in determining their achievement of competitive advantages, including differentiation-based competitive advantages (H2: λ = 0.222; t = 2.620) and cost-based competitive advantages (H3: λ = 0.330; t = 4.355). Finally each one of these variants of competitive advantage (differentiation-based and cost-based) showed a positive and significant influence on BGs’ international results (H4: λ = 0.208; t = 3.050 and H5: λ = 0.128; t = 2.093, respectively).
Results of the estimation of standardised parameters for the model of effects.
p<0.05.
p < 0.01.
p < 0.001.
5. Conclusions
This research was motivated by the large number of studies pointing to the important contribution BGs make to the progress of global economies. This circumstance has identified the study of the particularities that define BGs and that characterise their internationalisation process as a topic of major interest for academics and researchers [5, 6, 14, 17, 22]. Recent work in the international entrepreneurship field has urged researchers to contribute to the current understanding of firms’ rapid internationalisation processes through richer empirical and theoretical studies [7, 8, 17, 25]. In this line, the Journal of International Business Studies will dedicate a special issue in 2017 to the determination of the factors that facilitate the creation and capture of entrepreneurial opportunities across national borders.
In general, our work adds to the growing support in the recent literature to the consideration of market knowledge as a key factor that determines the speed with which new companies adopt a proactive approach in crossing their national borders to seize new opportunities in other foreign markets [19, 56, 95–98]. As Javalgi et al. [99: p.15] point out, in current dynamic contexts BGs ‘must listen to and correctly interpret the voice of the market. […] Firms that lose touch with the market, that either ignore or misinterpret its signals, will fail in hyper-competitive environments’.
Specifically, our findings contribute to the specialised literature with various relevant theoretical and empirical implications. First, gradualist models emphasise experience as an essential factor in the firm’s internationalisation process by centring on determining the most relevant sources of external market knowledge [1]. However, the experience derived from physical presence in foreign markets is minimal in the case of BGs due to their recent creation. Experience cannot therefore be considered as the main source of knowledge BGs use in their entry into foreign markets. For this reason, a growing number of scholars highlight the role of vicarious knowledge from relations in networks as key source of external information and knowledge in BGs [56, 57]. As Lin and Chen [65: p.160] note, ‘relationships between firms in a network context constitute an inter-organisational scenario for the exchange, compilation, integration and development of resources and valuable complementary knowledge that originally come from individual agents’. The links a BG builds into its network from its creation give it access to external information, knowledge, experiences and resources that it can apply internally [22]. In line with these arguments, the construct of NMO can be seen as a reference for determining how BGs generate and manage vicarious knowledge.
Second, based on ref. [37], our research enables theoretical identification and empirical testing of the behaviours and basic mechanisms that characterise the development of a coordinated market orientation among firms in BG networks. Our study responds to previous calls emphasising the need to complete the assumptions of individual market orientation with a relational view [43, 100, 101]. These findings show that the market orientation construct must be applied at individual and also network level [101], thereby supplementing the existing literature on the importance of individual market orientation in BGs [102, 103].
Furthermore, our results show that the knowledge these firms derive from their market-oriented networks helps them to develop an absorptive dynamic capability in order to act sustainably in their international markets. Therefore, BGs’ development of absorptive capability should not be understood as a completely internal process, but as a relational process. This finding contributes to the discussion around the lack of attention paid to identifying the main variables beyond BG competitiveness [13, 71–73]. Indeed, our study responds to some authors’ remarks that, despite the growing interest shown in recent years as a result of the intense process of globalisation in the markets, the theoretical and empirical knowledge about the internal and external antecedents of the international performance of new companies remains insufficient [13, 72, 73, 104, 105]. Our study complements previous literature in which analysis of these variables has tended to adopt an individual approach, highlighting the relevance for BGs of developing a market orientation [102, 103], an entrepreneurial orientation [3, 106, 107] or specific capabilities such as marketing and managerial capabilities [7, 22, 108, 109].
In sum, it is empirically demonstrated that adopting an orientation grounded in market knowledge and social networks (NMO) promotes the development by BGs of a dynamic absorptive capability that contributes to the systematic and effective adaptation to the dynamic and changing markets in which they operate, and the exploitation of the valuable knowledge generated. Our study integrates theoretical approaches from international business and entrepreneurship, providing a new framework that improves our understanding of the central role of knowledge in the way BGs capture and create opportunities across national borders.
6. Limitations and future research
The interpretation of the conclusions derived from this study should take into account some limitations, which lead us to propose certain future lines of research.
Regarding the theoretical limitations, our study proposes one particular model of effects to which other new relationships may be added, taking into account additional variables to complete the explanation of the achievement of competitive advantages and international performance by BGs.
Additionally, considering that our study complements the results from previous works that demonstrate from an individual perspective the influence of BGs’ market orientation on their competitiveness, future research could explore the relationship between an NMO and a particular market orientation.
Moreover, taking into account that BGs’ main internationalisation decisions are related to the speed and the mode they enter new foreign markets, future studies could analyse the influence of an NMO on different levels of speed and modes of entry.
Methodological limitations include the use of a single nation sample, since our findings may not be generalised to other national contexts. Future research could replicate and contrast the hypotheses presented in our work in other countries. We also used a multi-sector sample. Considering that networks may differ in their behaviour, structure and performance, future research could explore sectors, facilitating a larger homogeneity of firms and networks.
Another methodological limitation concerns the use of a single interviewee response per network and firm. This raises two questions: (1) Can the manager of an individual firm respond to questions on how a network of companies works as a whole? and (2) Similarly, can a single interviewee represent an entire company in his or her responses?
Further doubts may arise on the question of who actually responded to the questionnaire, bearing in mind that it was distributed online.
Finally, to make causal inferences using cross-sectional data can limit the value of the results. New research could usefully analyse the proposed model of effects with longitudinal data.
\n',keywords:"Born Globals, network market orientation, absorptive capability, competitiveness, international performance",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/56316.pdf",chapterXML:"https://mts.intechopen.com/source/xml/56316.xml",downloadPdfUrl:"/chapter/pdf-download/56316",previewPdfUrl:"/chapter/pdf-preview/56316",totalDownloads:1132,totalViews:222,totalCrossrefCites:1,totalDimensionsCites:1,totalAltmetricsMentions:0,impactScore:1,impactScorePercentile:66,impactScoreQuartile:3,hasAltmetrics:0,dateSubmitted:"April 29th 2016",dateReviewed:"June 8th 2017",datePrePublished:null,datePublished:"November 21st 2017",dateFinished:"July 4th 2017",readingETA:"0",abstract:"This chapter studies the influence of network market orientation (NMO) on Spanish Born Globals’ (BGs) competitiveness. The study analyses the contribution of a specific knowledge-based dynamic capability, namely absorptive capability, as a key mediator variable between NMO and competitiveness, finally influencing the international performance achieved by this particular type of firm. Results from testing the structural equation model proposed confirm that NMO facilitates the development of an absorptive capability in BGs and that this capability, in turn, influences the firms’ capacity to exploit the new relational knowledge, thus improving their competitiveness and international performance.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/56316",risUrl:"/chapter/ris/56316",book:{id:"5491",slug:"knowledge-management-strategies-and-applications"},signatures:"Diego Monferrer Tirado and Marta Estrada Guillén",authors:[{id:"190403",title:"Ph.D.",name:"Diego",middleName:null,surname:"Monferrer Tirado",fullName:"Diego Monferrer Tirado",slug:"diego-monferrer-tirado",email:"dmonferr@uji.es",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"Jaume I University",institutionURL:null,country:{name:"Spain"}}},{id:"190935",title:"Dr.",name:"Marta",middleName:null,surname:"Estrada Guillén",fullName:"Marta Estrada Guillén",slug:"marta-estrada-guillen",email:"estrada@uji.es",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Theoretical development",level:"1"},{id:"sec_2_2",title:"2.1. The relevance of NMO for BGs",level:"2"},{id:"sec_3_2",title:"2.2. NMO and absorptive capability in BGs",level:"2"},{id:"sec_4_2",title:"2.3. Absorptive capability and competitive advantages in BGs",level:"2"},{id:"sec_5_2",title:"2.4. Competitive advantages and international performance in BGs",level:"2"},{id:"sec_7",title:"3. Methodology",level:"1"},{id:"sec_7_2",title:"3.1. Sample selection and data collection",level:"2"},{id:"sec_8_2",title:"3.2. Measurement instruments",level:"2"},{id:"sec_9_2",title:"3.3. Validity and scale reliability",level:"2"},{id:"sec_11",title:"4. Results",level:"1"},{id:"sec_12",title:"5. Conclusions",level:"1"},{id:"sec_13",title:"6. Limitations and future research",level:"1"}],chapterReferences:[{id:"B1",body:'Johanson J, Vahlne JE. 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Teodor, Georgiana-Ileana Truica, Andreia Tache and Gabriel-Lucian Radu",authors:[{id:"24425",title:"Dr.",name:"Simona Carmen",middleName:null,surname:"Litescu",fullName:"Simona Carmen Litescu",slug:"simona-carmen-litescu"},{id:"24429",title:"Prof.",name:"Gabriel-Lucian",middleName:null,surname:"Radu",fullName:"Gabriel-Lucian Radu",slug:"gabriel-lucian-radu"},{id:"108318",title:"Dr.",name:"Eugenia D.",middleName:null,surname:"Teodor",fullName:"Eugenia D. Teodor",slug:"eugenia-d.-teodor"},{id:"108323",title:"Dr.",name:"Georgiana-Ileana",middleName:null,surname:"Badea",fullName:"Georgiana-Ileana Badea",slug:"georgiana-ileana-badea"},{id:"136337",title:"Ms.",name:"Andreia",middleName:null,surname:"Tache",fullName:"Andreia Tache",slug:"andreia-tache"}]},{id:"36184",title:"Infrared Spectroscopy in the Analysis of Building and Construction Materials",slug:"infrared-spectroscopy-of-cementitious-materials",signatures:"Lucia Fernández-Carrasco, D. Torrens-Martín, L.M. Morales and Sagrario Martínez-Ramírez",authors:[{id:"107401",title:"Dr.",name:"Lucia J",middleName:null,surname:"Fernández",fullName:"Lucia J Fernández",slug:"lucia-j-fernandez"}]},{id:"36185",title:"Infrared Spectroscopy Techniques in the Characterization of SOFC Functional Ceramics",slug:"infrared-spectroscopy-techniques-in-the-characterization-of-sofc-functional-ceramics",signatures:"Daniel A. Macedo, Moisés R. Cesário, Graziele L. Souza, Beatriz Cela, Carlos A. Paskocimas, Antonio E. Martinelli, Dulce M. A. Melo and Rubens M. Nascimento",authors:[{id:"102015",title:"MSc.",name:"Daniel",middleName:null,surname:"Macedo",fullName:"Daniel Macedo",slug:"daniel-macedo"},{id:"112309",title:"MSc",name:"Moisés",middleName:"Romolos",surname:"Cesário",fullName:"Moisés Cesário",slug:"moises-cesario"},{id:"112310",title:"Ms.",name:"Graziele",middleName:null,surname:"Souza",fullName:"Graziele Souza",slug:"graziele-souza"},{id:"112311",title:"MSc.",name:"Beatriz",middleName:null,surname:"Cela",fullName:"Beatriz Cela",slug:"beatriz-cela"},{id:"112312",title:"Prof.",name:"Carlos",middleName:null,surname:"Paskocimas",fullName:"Carlos Paskocimas",slug:"carlos-paskocimas"},{id:"112314",title:"Prof.",name:"Antonio",middleName:null,surname:"Martinelli",fullName:"Antonio Martinelli",slug:"antonio-martinelli"},{id:"112315",title:"Prof.",name:"Dulce",middleName:null,surname:"Melo",fullName:"Dulce Melo",slug:"dulce-melo"},{id:"112316",title:"Dr.",name:"Rubens",middleName:"Maribondo Do",surname:"Nascimento",fullName:"Rubens Nascimento",slug:"rubens-nascimento"}]},{id:"36186",title:"Infrared Spectroscopy of Functionalized Magnetic Nanoparticles",slug:"infrared-spectroscopy-of-functionalized-magnetic-nanoparticles",signatures:"Perla E. García Casillas, Claudia A. Rodriguez Gonzalez and Carlos A. Martínez Pérez",authors:[{id:"104636",title:"Dr.",name:"Perla E.",middleName:null,surname:"García Casillas",fullName:"Perla E. García Casillas",slug:"perla-e.-garcia-casillas"},{id:"112440",title:"Dr.",name:"Carlos A.",middleName:null,surname:"Martínez Pérez",fullName:"Carlos A. Martínez Pérez",slug:"carlos-a.-martinez-perez"},{id:"112441",title:"Dr.",name:"Claudia A.",middleName:null,surname:"Rodriguez Gonzalez",fullName:"Claudia A. 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Marais",authors:[{id:"112229",title:"Prof.",name:"Chris",middleName:null,surname:"Aldrich",fullName:"Chris Aldrich",slug:"chris-aldrich"},{id:"112232",title:"Prof.",name:"Hansie",middleName:null,surname:"Knoetze",fullName:"Hansie Knoetze",slug:"hansie-knoetze"},{id:"135327",title:"Ms.",name:"Corne",middleName:null,surname:"Marais",fullName:"Corne Marais",slug:"corne-marais"}]},{id:"36189",title:"Optical Technologies for Determination of Pesticide Residue",slug:"optical-technology-for-determination-of-pesticide-residue",signatures:"Yankun Peng, Yongyu Li and Jingjing Chen",authors:[{id:"113343",title:"Prof.",name:"Yankun",middleName:null,surname:"Peng",fullName:"Yankun Peng",slug:"yankun-peng"},{id:"116636",title:"Dr.",name:"Yongyu",middleName:null,surname:"Li",fullName:"Yongyu Li",slug:"yongyu-li"},{id:"116637",title:"Dr.",name:"Jingjing",middleName:null,surname:"Chen",fullName:"Jingjing Chen",slug:"jingjing-chen"}]},{id:"36190",title:"High Resolution Far Infrared Spectra of the Semiconductor Alloys Obtained Using the Synchrotron Radiation as Source",slug:"high-resolution-spectra-of-semiconductor-s-alloys-obtained-using-the-far-infrared-synchrotron-radi",signatures:"E.M. 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1. Introduction
Malaysia is located in the equatorial region where most parts of the natural landscape are covered by the tropical rainforests. The country is well known for its rich flora and fauna biodiversity. Non-human primate species found natively in Malaysia include the great ape: Bornean orangutan (Pongo pygmaeus); lesser ape: Agile gibbon (Hylobates agilis), White-handed gibbon (Hylobates lar), Bornean gibbon (Hylobates muelleri), Siamang (Symphalangussyndactylus); old world monkeys: Banded leaf monkey (Presbytis femoralis), White-fronted langur (Presbytis frontata), Gray leaf monkey (Presbytis hosei), Red leaf monkey (Presbytis rubicunda), Silver leaf monkey (Trachypithecuscristatus), Dusky leaf monkey (Hylobates funereus obscurus), Long-tailed macaque (Macaca fascicularis), pig-tailed macaque (Macaca nemestrina), stump-tailed macaque(Macaca arctoides); the lorisids: Sunda slow loris (Nycticebuscoucang), Kayan slow loris (Nycticebuskayan); lastly the Western tarsier (Tarsiusbancanus).
The focus of this chapter is management aspects of macaques as the conservation of these species is generally neglected in the country. They were at the extreme end of the conservation status as indicated by the IUCN Red List of Threatened Species, where long-tailed macaques are categorized as least concerned, while the pig-tailed macaques are endangered. Furthermore, reports, conservation efforts, and research centers on macaques are almost unheard of, except human-macaque conflicts that mainly involved the long-tailed macaques. It may be fortunate that young macaques do not appear cute and cuddly compared to that of orangutans and leaf monkeys, they are less often reported to be illegally traded or poached. However, this may also be one of the reasons they are not seen as “attractive” subjects of for research and conservation. Therefore, this chapter aspires to highlight the plight of macaques.
2. The macaques population in Malaysia
Although the long-tailed macaques are considered as pests in Malaysia, the species is listed as vulnerable under the IUCN Red List [1]. This is particularly true as their natural habitats are diminishing. According a report by Wicke et al. [2], Malaysia has lost 20 percent of forest land within a 30-year span due to anthropogenic activities. The downward trend of primary forest cover continues. The 91.9% of the cover remained in 2011 was further reduced to 83% in 2020 [3]. Although deforestation was significantly controlled over the past decade, the conversion of forest land is expected to continue creating more fragmented forest areas and forest edges [4], which are suitable habitats for long-tailed macaques. Subsequently, this would further escalate the frequencies of human-wildlife conflicts. Continuous mass removal of the long-tailed macaque which has been adopted to minimize human-wildlife conflicts subject the species to a risk of losing genetic diversity [5]. In fact, hybridization of populations and potential inbreeding depression of the populations could potentially occur if translocation operations intensified [6]. Additionally, long-tailed macaques in Peninsular Malaysia are morphologically assigned to two subspecies, namely M. f. fascicularis and M. f. argentimembris [7].
On the other hand, pig-tailed macaques and long-tailed macaques are generally regarded as crop raiders and, therefore, have more direct negative interactions with people. However, pig-tailed macaques have proved to be beneficial to mankind. They have traditionally been kept and trained to harvest fruits, especially coconuts, and forest products for over a century in Malaysia and other countries in Southeast Asia as the species is bigger and has more physical strength than long-tailed macaques. A recent research has indicated that the presence of pig-tailed macaques benefits the oil palm plantations by acting as a biological control for rodents that cause the industry monetary losses of US$930mil (RM3.9bil) every year [8]. In comparison, the damage caused by the pig-tailed macaques on the oil palm crops is relatively minimal.
Pig-tailed macaques are listed as endangered in Malaysia since 2009, although it is still categorized as vulnerable when the entire population worldwide is considered [9]. It is of interest to note that both long-tailed macaques and pig-tailed macaques shared similar natural habitats and are omnivorous. However, the latter is more sociable towards humans, less aggressive, and more habituated. Currently, efforts to conserve the species in the wild are not viewed as critical. The breeding of pig-tailed macaques is generally undertaken as the animals are needed for fruit plucking purposes. Yet, this effort is not nationwide, but concentrated only in the East Coast of Peninsular Malaysia and mostly unable to sustain the population if the animals go extinct in the wild.
Stump-tailed macaques are found only in the North-western region in Peninsular Malaysia, specifically at the Wan Kelian forest areas in Perlis State Park. In fact, the global geographical range published by IUCN indicated that this is the most southern region where stump-tailed macaques can be detected. Their presence could be found further north in Thailand, Myanmar, Laos, Cambodia, Vietnam, Bangladesh, and China. Distributions of the stump-tailed macaques are similarly in habitat pockets as in Malaysia, not widespread throughout the countries listed, and the populations are mostly declining [10]. Unfortunately, wildlife censuses have been excluding macaques as the species of interest in research, thus making more recent data unavailable. Despite its vulnerable status under the IUCN Red List [11], these macaques received the least attention from the government, public, and even researchers compared to the other two macaque species in Malaysia [7, 12]. Small population size, movement between country borders (Malaysia and Thailand) which that is prone to heavy poaching, and their tendencies to avoid humans [12] further complicate research of this species. It is interesting to note that all three macaque species: stump-tailed macaques,pig-tailed macaques and long-tailed macaques are found sympatrically within the Perlis State Park Forest Areas [12, 13]. However, interspecies associations were not recorded between the three species [12, 14].
3. Macaques involvement in human-wildlife conflicts
Among the non-human primate species found in the country, the long-tailed macaques and pig-tailed macaques can be found in areas that often overlap with high anthropogenic activity areas such as plantations, the secondary forest surrounding human settlements, besides their natural habitats in the wild [1, 9]. Between the two species, the long-tailed macaques are most sighted and involved in human-wildlife conflicts in both rural and urban areas, accounting for between 35 and over 65 percent of conflict reports received by the wildlife department [15, 16]. This species has successfully adapted to the human settlements and continues to multiply at alarming rates, which further contributes to human-wildlife conflicts. The damages caused by macaque related conflicts include injuries such as scratches and bites sustained by people during the encounter with macaques, destruction of properties and materials within when macaques enter and ransack the properties, disturbance to residents and tourists due to the animals’ aggressive behavior [17] to snatch and steal when needed.
In general, the main reason for human-wildlife conflicts caused by long-tailed macaques is food motivation. Conversely, by and large, these past behaviors were triggered by human actions: feeding of animals by “good samaritans”, an improper garbage disposal that allow animals to forage for scraps, destruction of natural habitats due to deforestation and agricultural activities, and encroachment of human settlement into the forested areas [18]. The authorities manage the macaque human-wildlife conflict through several approaches including culling, public education, and awareness creation program (particularly with the help of non-government organizations), and translocation of the animals (Pers. Observation).
A study on the dietary composition of wild stump-tailed macaques indicated that they mainly consume plant materials from the forest [19]. Unlike its cousins, the long-tailed macaques and pig-tailed macaques are more often spotted at human concentrated areas, and at times orchards, plantations, and even garbage collection sites. Essentially, absence of human-wildlife conflict reports on stump-tailed macaques explains why public knowledge on the species is minimal.
4. Zoonotic diseases in macaques
The genetic relatedness of non-human-primates to humans generally gives the perception that interaction with non-human-primates poses higher zoonotic risks compared to other animal species. The natural habitats of non-human-primates are located at the equatorial zone worldwide, expanding across tropical rainforest in Southeast Asia, West and Central Africa, and South and Central America, also smaller patches in areas adjacent to these. Additionally, non-human-primates can be found in captivity such as in zoological gardens, rescue centers, and animal research facilities. Therefore, it is logical to acknowledge that a large portion of the human population has direct or indirect contact with non-human primates, thus making zoonotic disease spillover a major public health concern. Additionally, interactions of non-human primates with livestock have been reported to initiate multidirectional pathogen transmission between these species, and ultimately lead to spillover to the human population [20]. This is further evident from host-pathogen databases analysis among primates showed that sympatric host species have high probabilities to share parasite species [21].
Interestingly, consumption of bushmeat from non-human primates is not widely practiced or acceptable by the local communities, mainly due to religious practices among the majority of the population. This might have significantly reduced the probability of zoonotic diseases transmission and potential mutagenic changes in the pathogens, particularly viruses. Most popular bushmeat in Malaysia is reportedly from wild pigs (Sus scrofa), bearded pigs (Sus barbatus), deer (including Sambar deer (Cervus unicolor), barking deer (Muntiacus muntjac) and mousedeer (Tragulus kanchil and Tragulus napu), Malayan porcupine (Hystrix brachyura), bats, and others [22, 23, 24, 25].On the other hand, sun bears (Helarctos malayanus)were hunted for their bile to cater for traditional medicines [26]. Some examples of zoonotic or potential zoonotic diseases reported in macaques are discussed hereunder. However, a comprehensive description of zoonotic disease risks from macaques is still lacking. The degree of impact of macaques on possible future epidemics needs to be elucidated with further studies utilizing the one health approach integrating data on human, animal, and environmental health. Epidemiology of diseases often stimulates research in wildlife species, especially in the recent years with emerging zoonotic diseases suspected to have originated from wildlife as evidenced from a large number of scientific articles published [27, 28, 29, 30]. Conversely, conservation of these species could result in the preservation of ecosystem integrity and creating a buffer zone against novel disease outbreaks [31]. The outcomes from studies of these species may help the conservation authorities to strategize the long-term plans and inform the national policies on effective management and conservation of macaques species in Malaysia.
5. Bacterial diseases
Fecal samples from wild long-tailed macaques and pig-tailed macaques involved in human-wildlife conflicts areas in the Lopburi district of Thailand were found to carry Esherichai coli, Staphylococcus spp, and Salmonella spp. [32]. In another study carried out in the Wulongkou Scenic Area, Henan Province of China discovered that about a quarter of over 400 fecal samples contained Shigella spp., Escherichia coli, Klebsiella pneumoniae, and Leptospira spp. Other bacteria detected in lesser prevalence included Campylobacter jejuni, Salmonella spp., Staphylococcus aureus, Streptococcus pneumonia, Yersinia spp., and Hafnia paralvei. Among these bacteria, Salmonella, Shigella, E. coli, C. jejuni, and Yersinia are zoonotic i.e. shared with humans and other animals.
In a preliminary study of zoonotic pathogens in captive pig-tailed macaques detected Neisseria spp. in all four swab samples, namely nasal, buccal, throat, and anal, from 30 individuals. Other bacteria isolated were Pasturella spp. and Moraxella spp. from the nasal swabs, and Stenotrophomonas sp. or Acinetobacter sp. from the buccal swabs. Whereas for the anal swabs, Pasturella spp., and Streptobacillus spp. were detected, besides Neisseria spp. [33]. The different species isolated in the previous studies with the current research may be due to the fact that the former was from wild animals, and fresh droppings were collected, while the latter was from captive macaques and collected directly from multiple orifices of the animals.
6. Viral diseases
RNA viruses are considered a major threat among emerging infectious diseases at the human-non-human primate interface [34], and studies conducted in Malaysia are very much concentrated on this group of viruses. As discussed before, long-tailed macaques are involved in most of the human-macaque conflicts and often these issues were dealt with through capture and relocation to deep forest areas [35, 36]. Therefore, researchers took the opportunity to investigate the viruses carried by these animals to determine if these animals could serve as a reservoir host for these pathogens and pose significant disease threats to human and other animal species in the habitat.
In a study by Ain-Najwa et al. [37] using archived long-tailed macaque samples, where sera were used to detect West Nile virus (WNV) antibody through competitive enzyme-linked immunosorbent assay (c-ELISA), and WNV RNA from oropharyngeal swabs via RT-PCR. Results showed that the macaques were all negative for WNV RNA, yet high WNV antibody prevalence was observed. These results may indicate that the macaques are exposed to WNV from other animals in their habitat, yet infectivity was low, and they may not serve as a reservoir to WNV in the wild.
In Malaysia, Zika virus (ZIKV) was detected in 0.2% of patients with clinical signs corresponding to Zika virus infection during the Malaysia ZIKV surveillance between June 2015 and December 2017 after the declaration of the Public Health Emergency of International Concern (PHEIC) by World Health Organization. The source of infection was undetermined and possible zoonotic transmission from wildlife species, such as macaques, was suspected [38]. A total of 234 long-tailed macaques trapped from multiple sites throughout Peninsular Malaysia in the Wildlife Disease Surveillance Program were evaluated for ZIKV prevalence. The researchers were unable to detect ZIKV RNA from any of the macaques sampled, and only 1.3% showed seropositive for neutralizing antibodies. Thus, the study concluded that long-tailed macaques are not likely to be reservoirs for the Zika virus in Malaysia [39].
On the other hand, Malaysia has experienced massive outbreaks of Chikungunya virus (CHIKV) infection in humans in Malaysia between 1998 and 1999 [40] and cases have been reported since with sporadic surges of infections recorded [41]. Researches were conducted to elucidate the potential of macaques in maintaining the Chikungunya virus during inter-epidemic periods, to explain the sporadic disease occurrences, as the virus has been isolated from monkeys in Africa [42]. A study carried out by Sam et al. (2015) found that viraemia among the wild long-tailed macaques tested was not only lacking but also the seroprevalence rate was low. Therefore, it was concluded that long-tailed macaques living at the human-wildlife conflict areas would have played a minor role in CHIKV transmission, if any, during CHIKV outbreak episodes [36]. In fact, later work by Suhana et al. [43] suggested that CHIKV detected in long-tailed macaques may be a spillover of the virus from humans, based on molecular characterization and phylogenetic analysis of the isolates.
Macacine herpesvirus 1 (MaHV1), commonly known as B virus, has been detected among wild macaques in Asia [44]. However, there is minimal information regarding MaHV1 in macaques of Malaysia. To date, there was only one report indicating that 39% of wild long-tailed macaques sampled from six different states in the country during wildlife management program under the Department of Wildlife and National Parks, Peninsular Malaysia was shedding MaHV1 DNA [45]. While animals from different age groups were detected to shed the virus, through PCR of urogenital and oropharyngeal swabs, seroprevalence through ELISA was highest among the adults [45]. The seroprevalence result corresponded with a previous study from Bali, Indonesia, where most adults were expected to have been infected or exposed to MaHV1 [46]. MaHV1 is designated as Biosafety Level 4 (BSL-4) pathogen because humans with untreated MaHV1 infection have over 70% mortality rate [47]. With the high human-macaque conflict reported in Malaysia, wildlife officers and rangers carried out many translocation operations as a mitigation approach; also reports of bites and scratches from macaques are rather common among people that reside in or visited areas with macaques. In fact, some persons bitten and scratched by macaques may have experienced MAHV1 infection yet did not experience clinical signs of infections [48]. However, peculiar reports of human MaHV1 infections were confined to personnel working with macaques or macaque tissues in a husbandry or research environment in the US and Europe. This could be explained by the fact that wild macaques are not shedding the virus in such high concentrations compared to laboratory animals, as the latter may be constantly confined in captivity and exposed to high-stress conditions, where they are handled and manipulated. While their wild cousins are generally free in their natural habitat, and people only have random and occasional encounters with these animals [49]. Even so, workers in contact with wild macaques are recommended to put on appropriate personal protective equipment, as capture and translocation efforts may induce stress on these animals and increased viral shedding or reactivation of infection that could potentially infect the workers [45].
In a preliminary study [33] of captive pig-tailed macaques showed the prevalence of several RNA viruses, such as retrovirus, influenza virus, and lyssavirus, through RT-PCR of the buffy coat. Retrovirus was detected in all individuals sampled, followed by influenza virus (56.6%), then lyssavirus at 13.3%. Further investigation using cell culture and nested PCR to detect Simian Foamy virus (SFV) from these samples as SFV has been reported to infect nearly all captive and free-ranging macaques in Asia [50, 51]. HeLa cell culture demonstrated cytopathogenic effects (CPEs) such as being refractile, detached from the culture surface, floating, clumping, increased in cell distance after just the first passage, and foamy appearance was observed in the cells under high magnification by the third passage [33]. However, detection of SFV using nested PCR targeting the Pol genes and LTR genes from extracted trypsinized tissue culture samples did not turn up positive results. Therefore, further work is required to determine if CPE resulted from SFV or other viruses.
Overall, evidence that wild and captive macaques in Malaysia serve as a reservoir for zoonotic viruses is still lacking. Zoonotic infections from macaque to human is very much understudied, and often prevalence research on pathogens in macaques are not incorporated with sampling from the keepers, owners, and other personnel in contact, such as the wildlife rangers. Additionally, pig-tailed macaque owners surveyed did not report illness related to animals kept, as these animals often share the living quarters, food, and drinks with their owners. However, it is safe to say that personnel in contact with macaques should take the necessary precautions to minimize infection transmission from these animals.
7. Parasitic diseases
The most prominent zoonotic parasite reported in macaques is Plasmodium knowlesi, recognized as the fifth cause of human malaria, which is transmitted from animals to humans through Anopheles mosquito vector. Knowlesi malaria has now topped the number of human malaria cases reported across most states in Malaysia, especially in Sabah and Sarawak [52, 53]. This situation may be as a result of increased encroachment of human settlement into the forested areas [54], and advancement of malaria diagnosis to molecular method instead of the conventional microscopy detection of the stained blood smear [55].
On another note, gastrointestinal (GI) parasites from macaques are often neglected although these organisms may cause detrimental consequences in humans. A report from Baluran National Park at East Java, Indonesia indicated 89% of fecal samples collected from wild long-tailed macaque were positive of GI parasite, and protozoal infection was slightly higher (89%) compared to helminth (83%). The study found that the most prevalent GI parasite in the macaques is Trichostrongylussp (66%), the next highest parasite is Entamoeba sp. (53%), and followed by Strongyloides sp. (32%), Blastocystis sp. (32%), Trichuris sp. (17%), Giardia sp. (10%) and Enterobius sp. (3%) [56]. Conversely, the prevalence of GI parasites infection was lower at the Kosumpee Forest Park, MahaSarakham, Thailand, where only 35.11% of the fecal samples were positive, including Strongyloides spp. (15.27%), Trichuris spp. (22.9%), hookworm (4.58%) and Ascaris spp. (1.53%) [57].
A comprehensive project was undertaken to investigate GI parasites in Malaysia’s non-human primates from the wild, and animals living in urban habitats, and the ones in captivity. This study examined a total of 12 local non-human primate species and illustrated at least 44 species of GI parasites were detected, including seven species of protozoans, 26 species of nematodes, five species of cestodes, five species of trematodes, and one species of pentastomida. The GI parasite distributions were not significantly different between the three groups, and the most prevalent GI parasite was Ascaris spp. (49.7%), followed by Oesophagostomum spp. (26.9%) [58]. A study specifically looking into captive pig-tailed macaques showed that an overall GI parasite prevalence rate of 52%. Among the species, five species belonged to Nematoda viz. Anatrichosoma sp., Capillaridae, Strongyloides sp., Trichostrongylus sp., and Trichuris sp. Only one Trematoda species was detected, which is Paramphistomum sp. The most common GI parasites are Trichuris sp. (38%), followed by Trichostrongylus sp. (24%), Paramphistomum sp. (14%), Anatrichosoma sp. and Strongyloides sp. (10%) each, and lastly Capillaridae (5%). It should be noted that about one-third of animals tested had double GI parasite infection (33%), 14% of the infection was single, and 5% had a triple infection. Most of the macaque owners did not administer anthelmintics to their animals as preventive medicine. The authors also examined thick blood smears from these captive pig-tailed macaques and found one sample positive for filaria nematode [59].
On the whole, the GI parasites and haemoparasite identified in these studies are of known public health importance and zoonotic concern that needs to be seriously addressed, specifically raising awareness of people in close contact with macaques.
8. Population control
Due to the success of the long-tailed macaques in adapting to human settlements, particularly in the urban areas, they are the culprit in most reported human-wildlife conflict cases in Malaysia, up to 65% of total annual case reports, compared to any other wildlife species [15, 16, 17]. It is most often created serious public nuisance and concerns on the animals causing property damage and bodily harm to people encountered during the conflict episodes. The short-term solution most often resorted to is population control, in the hope to reduce the occurrence of conflicts.
Currently, an effective contraceptive method, besides capturing and physical handling of the animals for surgical and non-surgical neutering methods, is lacking. Zona pellucida vaccination, oral contraceptives are temporary and require reapplication, which is troublesome, labor intensive, and recurring cost. Neutering needs animals to be captured, especially for the females as surgical methods involve laparotomy. The effort starts with procuring and setting up suitable traps, then to restrain, anesthetize, and application of chemical or surgical methods for permanent sterilization.
The most frequently used method for sterilization of the male macaques is castration that involves the removal of the testicles, and this procedure does not require an invasive procedure into the abdominal cavity. Compared with the procedures in the females, often healing time is much quicker and may not require an extended holding period. In a report by Karuppannan et al. [60], non-surgical castration through intraepididymal injections of ethanol-formalin mixture to induce tubular blockage resulted in over 90 percent (32/35) success among the animals tested. This method is labor intensive, requires the animals to be caught first, training of staff and precision during the injection process. Furthermore, this method is most suitable for adult males as epididymis in juveniles and subadults are small and difficult to locate to ensure accurate injection of the ethanol-formalin mixture. This chemical castration method is compared to surgical castration that requires surgical skills and can only be performed by veterinarians, yet the age of animals is usually not an issue for successful removal of testis. However, the chemical approach can be done within a shorter period and the males are expected to sustain their sexual behavior as the testicular tissues remained intact [60].
The impact of castration on male macaques is still debatable. Castration does not appear to impact the social interactions between male Japanese macaques (Macaca fuscata) in the group. Instead of linear hierarchy as in the intact males, castrated males are less aggressive and have a more lateral relationship with one another [61]. Thus, Takeshita et al. [61] recommend that castration can be adopted as an effective population control measure. On the other hand, studies indicated possible dental health issues where castrated rhesus macaques (Macaca mulatta) that lived till old age have greatly receded alveolar bone with signs of periodontitis more severe than in intact old males, as well as severe temporomandibular joint osteoarthritis in the former [62]. The Department of Wildlife and National Parks would adopt the chemical castration described above as this method would not affect male hormone levels in the animals [60].
On the other hand, sterilization in females will definitely necessitate penetration of the abdominal cavity for removal of the ovaries, and/or the uterus. The length of incision and operation period depends on the method chosen, through laparotomy or laparoscopic approach. Surgical methods have been reported in other countries, the caveat of laparotomy for ovariohysterectomy in the female would require the animals to be kept for at least three to 4 days before release to ensure the suture site has healed. This will require facilities to temporarily house the animals. The use of laparoscopy may alleviate this problem, where tubectomy, removal of the Fallopian tube, ovariectomy (removal of ovaries) in females; and vasectomy in males can be conducted. If done correctly, only two to three small and bloodless (or minimal bleeding) incisions are required to access the reproductive organs [63]. The use of a laparoscope has minimized the length of the abdominal incision, especially in females [64]. Nevertheless, the downside of laparoscopic procedures is costly equipment, the requirement of trained staff, and electricity supply.
9. Conservation of macaques in Malaysia
Malaysia is inhabited by ≥25 non-human primate species from five families, one of the most diverse primate faunas on earth. Unfortunately, most of these primates are threatened with extinction due to habitat loss, degradation and fragmentation, hunting, and the synergies among these processes. Despite the charisma and cultural importance of primates, the significance of primates in ecological processes such as seed dispersal, and the robust development of biodiversity-related sciences in Malaysia, there is relatively little research specifically focusing on wild primates since the 1980s. Forest clearing for plantation agriculture has been a primary driver of forest loss and fragmentation in Malaysia. Selective logging has also negatively impacted the primates. However, these impacts vary across primate taxa. Previously-logged forests were important habitats for many Malaysian primates. Malaysia is crossed by a dense road network, which fragments primate habitats, facilitates further human encroachment into forested areas, and causes substantial mortality due to road kills.
Primates in Malaysia are hunted for food or subjected to retaliatory or pre-emptive killing as pests, trapped for translocation to minimize human-wildlife conflicts, and captured for illegal trade as pets. Additionally, translocation operations should consider conservation of the unique evolutionary lineages of the macaque species, particularly the long-tailed macaques found to be of two distinctive subspecies [5]. Further research on the distribution, abundance, ecology, and behavioral biology of Malaysian primates is needed to inform effective management interventions. Outreach and education are also essential to reduce primate-human conflicts and illegal trade targeting primates as pets. Ultimately, researchers, civil organizations, government authorities, and local and indigenous communities in Malaysia must work together to develop, promote and implement effective strategies to protect Malaysian primates and their habitats.
Of the three macaque species, long-tailed macaques seemed to be able to adapt well within human settlements, despite a high number of human-wildlife conflicts reported [15]. The major conservation challenge facing macaque is habitat loss, degradation, and fragmentation resulting from forest clearing for plantation agriculture, selective logging, and a dense network of roads connecting many cities and townships in the country [65]. Macaques may not be popular as bushmeat, but are also trapped or hunted for illegal trade as pets [65]. Further research on habitat needs for all macaque species is imperative in order to understand the disparity of population density between the species, despite the similarities of natural habitats, diet, and behavior. A good example is a study conducted by Holzner et al. [66] citing the significant changes in sociality behavior of pig-tailed macaques that visit oil palm plantations in Malaysia, which may debilitate individual fitness and infant survival. This proves that despite the ability of pig-tailed macaques to temporarily adapt to human-altered habitats, the proximity of forest is vital for the survival of the species. Research done in recent years indicated an urgent need for macaque conservation strategies to preserve the remaining and segregated pig-tailed macaque and stump-tailed macaque populations involving the authorities, local communities, and general public [12, 67]. The authorities and non-government organizations are urged to increase public awareness on macaque species, particularly their roles in the ecosystem, as little is known about the species.
\n',keywords:"macaque conservation, non-human primate conservation, public health, zoonoses",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/79397.pdf",chapterXML:"https://mts.intechopen.com/source/xml/79397.xml",downloadPdfUrl:"/chapter/pdf-download/79397",previewPdfUrl:"/chapter/pdf-preview/79397",totalDownloads:149,totalViews:0,totalCrossrefCites:0,dateSubmitted:"July 12th 2021",dateReviewed:"October 8th 2021",datePrePublished:"November 22nd 2021",datePublished:"December 8th 2021",dateFinished:"November 22nd 2021",readingETA:"0",abstract:"Macaques are commonly found in Malaysia, with the current existing three species placed between endangered to least concern status under the IUCN Red List, namely the stump-tailed macaque (Macaca arctoides), pig-tailed macaque (Macaca nemestrina), and the notorious long-tailed macaque (Macaca fascicularis). The species classified under the endangered and vulnerable group are facing threats mainly from the loss of habitat. Conversely, species that are categorized as least concerned are often cited at the top of human-wildlife conflicts reports in various countries, although they too are facing pressure from habitat loss. There are different methods employed to control the fast-growing population of these species, calling for different levels of investment in terms of resources. It is of great interest to understand the disparities between these species, as they are able to adapt to environmental changes and some find ways to survive in alternative localities, including urban areas. The proximity of macaques to human dwellings raises a public health concern through the transmission of zoonotic diseases. More scientific studies are imperative in order to further understand the needs of these animals for continued survival and co-existence with humans and other animals in the ecosystem. Urgent efforts must be taken to preserve the macaque’s natural habitats while creating the public awareness on the predicament of these species. The focus should be on human-wildlife conflicts todispute the existing false impression that all macaques are on equal ground and abundance in numbers.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/79397",risUrl:"/chapter/ris/79397",signatures:"Siew Shean Choong, Mimi Armiladiana Mohamad, Li Peng Tan and Ruhil Hayati Hamdan",book:{id:"8834",type:"book",title:"Managing Wildlife in a Changing World",subtitle:null,fullTitle:"Managing Wildlife in a Changing World",slug:"managing-wildlife-in-a-changing-world",publishedDate:"December 8th 2021",bookSignature:"Jafari R. Kideghesho",coverURL:"https://cdn.intechopen.com/books/images_new/8834.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:"978-1-83880-976-8",printIsbn:"978-1-83880-975-1",pdfIsbn:"978-1-83880-977-5",isAvailableForWebshopOrdering:!0,editors:[{id:"280695",title:"Prof.",name:"Jafari R.",middleName:null,surname:"Kideghesho",slug:"jafari-r.-kideghesho",fullName:"Jafari R. Kideghesho"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"332287",title:"Dr.",name:"Siew Shean",middleName:null,surname:"Choong",fullName:"Siew Shean Choong",slug:"siew-shean-choong",email:"shean.cs@umk.edu.my",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"426575",title:"Dr.",name:"Mimi Armiladiana",middleName:null,surname:"Mohamad",fullName:"Mimi Armiladiana Mohamad",slug:"mimi-armiladiana-mohamad",email:"armila@umk.edu.my",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"Universiti Malaysia Kelantan",institutionURL:null,country:{name:"Malaysia"}}},{id:"426643",title:"Dr.",name:"Li Peng",middleName:null,surname:"Tan",fullName:"Li Peng Tan",slug:"li-peng-tan",email:"li.peng@umk.edu.my",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"Universiti Malaysia Kelantan",institutionURL:null,country:{name:"Malaysia"}}},{id:"426644",title:"Dr.",name:"Ruhil Hayati",middleName:null,surname:"Hamdan",fullName:"Ruhil Hayati Hamdan",slug:"ruhil-hayati-hamdan",email:"ruhil@umk.edu.my",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"Universiti Malaysia Kelantan",institutionURL:null,country:{name:"Malaysia"}}}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. The macaques population in Malaysia",level:"1"},{id:"sec_3",title:"3. Macaques involvement in human-wildlife conflicts",level:"1"},{id:"sec_4",title:"4. Zoonotic diseases in macaques",level:"1"},{id:"sec_5",title:"5. Bacterial diseases",level:"1"},{id:"sec_6",title:"6. Viral diseases",level:"1"},{id:"sec_7",title:"7. Parasitic diseases",level:"1"},{id:"sec_8",title:"8. Population control",level:"1"},{id:"sec_9",title:"9. Conservation of macaques in Malaysia",level:"1"}],chapterReferences:[{id:"B1",body:'Eudey, A., Kumar, A., Singh, M. &Boonratana, R. (2020) Macaca fascicularis. The IUCN Red List of Threatened Species 2020: e.T12551A17949449. [Internet]. Available from: https://dx.doi.org/10.2305/IUCN.UK.2020-2.RLTS.T12551A17949449.en [Accessed: 2020-12-16]'},{id:"B2",body:'Wicke B, Sikkema R, Dornburg V, Faaij A. Exploring land use changes and the role of palm oil production in Indonesia and Malaysia. Land Use Policy. 2011;28(1):193-206'},{id:"B3",body:'Global Forest Watch (2021) Primary forest loss in Malaysia. https://gfw.global/3gtXC2v'},{id:"B4",body:'Omran A, Schwarz-Herion O. Deforestation in Malaysia: The Current Practice and the Way Forward. In: Omran A, Schwarz-Herion O, editors. Sustaining our Environment for Better Future. Singapore: Springer; 2020. DOI: 10.1007/978-981-13-7158-5_11'},{id:"B5",body:'Abdul-Latiff MAB, Ruslin F, Faiq H, Hairul MS, Rovie-Ryan JJ, Abdul-Patah P, et al. Continental monophyly and molecular divergence of peninsular Malaysia’s. Macaca Fascicularis fascicularis. 2014;2014:897682'},{id:"B6",body:'DeSalle R, Amato G. The expansion of conservation genetics. Nature Reviews. Genetics. 2004;5(9):702-712. DOI: 10.1038/nrg1425 PMID: 15372093'},{id:"B7",body:'Abdul-Latiff MAB, Abdul-Patah P, Yaakop S, Md-Zain BM. Aiding pest control management of long-tailed macaques (Macaca fascicularis fascicularis) in Malaysia by using molecular markers of mitochondrial DNA. AIP Conference Proceedings. 2017;1891:020003. DOI: 10.1063/1.5005336'},{id:"B8",body:'Holzner A, Ruppert N, Swat F, Schmidt M, Weiß BM, Villa G, et al. Macaques can contribute to greener practices in oil palm plantations when used as biological pest control. Current Biology. 2019;29(20):R1066-R1067'},{id:"B9",body:'Ang, A., Boonratana, R., Choudhury, A. &Supriatna, J. (2020) Macaca nemestrina. The IUCN Red List of Threatened Species 2020: e.T12555A181324867. [Internet]. Available from: https://dx.doi.org/10.2305/IUCN.UK.2020-3.RLTS.T12555A181324867.en. [Accessed: 2020-12-16]'},{id:"B10",body:'Molur S, Brandon-Jones D, Dittus W, Eudey A, Kumar A, Singh M, et al. The Status of South Asian Primates: Conservation Assessment and Management Plan (CAMP) Workshop Report. 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Phylogeny and geography predict pathogen community similarity in wild primates and humans. Proc Roy Soc B. 2008;275:1695-1701'},{id:"B22",body:'Anon. Bush meat widely sold in Sabah. In: The Star. Petaling Jaya, WP: Star Media Group Berhad; 2015 https://www.thestar.com.my/news/nation/2015/11/23/bush-meat-widely-sold-in-sabah/'},{id:"B23",body:'Lee TM, Sigouin A, Pinedo-Vasquez M, Nasi R. The harvest of wildlife for bushmeat and traditional medicine in East, South and Southeast Asia: Current knowledge base, challenges, opportunities and areas for future research. In: Occasional Paper 115. Bogor, Indonesia: CIFOR; 2014'},{id:"B24",body:'Then S. Trade in bushmeat and body parts depleting wildlife population in Sarawak. In: The Star. 2020 https://www.thestar.com.my/metro/metro-news/2020/12/01/trade-in-bushmeat-and-body-parts-depleting-wildlife-population-in-sarawak'},{id:"B25",body:'Yii MCK, Mohd-Azlan J. Wildlife Hunting and Utilization in Ulu Baleh, Sarawak, Malaysian Borneo. 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DOI: 10.1186/s12879-019-3786-9'},{id:"B39",body:'Chua C, Chan Y, Andu E, Rovie-Ryan JJ, Sitam F, Verasahib K, et al. Little Evidence of Zika Virus Infection in Wild Long-tailed Macaques. Peninsular Malaysia. Emerging Infectious Diseases. 2019;25(2):374-376. DOI: 10.3201/eid2502.180258'},{id:"B40",body:'Lam SK, Chua KB, Hooi PS, Rahimah MA, Kumari S, Tharmaratnam M, et al. Chikungunya infection--an emerging disease in Malaysia. The Southeast Asian Journal of Tropical Medicine and Public Health. 2001;32(3):447-451 PMID: 11944696'},{id:"B41",body:'AbuBakar S, Sam IC, Wong PF, MatRahim N, Hooi PS, Roslan N. Reemergence of endemic Chikungunya, Malaysia. Emerging Infectious Diseases. 2007;13(1):147-149. DOI: 10.3201/eid1301.060617. PMID: 17370532; PMCID: PMC2725805'},{id:"B42",body:'Diallo M, Thonnon J, Traore-Lamizana M, Fontenille D. Vectors of chikungunya virus in Senegal: current data and transmission cycles. The American Journal of Tropical Medicine and Hygiene. 1990;60:281-286'},{id:"B43",body:'Suhana O, Nazni WA, Apandi Y, Farah H, Lee HL, Sofian-Azirun M. Insight into the origin of chikungunya virus in Malaysian non-human primates via sequence analysis. Heliyon. 2019;5(12):e02682. DOI: 10.1016/j.heliyon.2019.e02682'},{id:"B44",body:'Cohen JI. Chapter 144 - Herpes B Virus. In: Bennett JE, Dolin R, Blaser MJ, editors. Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases (Eighth Edition). New York: W.B. Saunders; 2015. pp. 1783-1786, ISBN 9781455748013. DOI: 10.1016/B978-1-4557-4801-3.00144-2'},{id:"B45",body:'Lee M, Rostal MK, Hughes T, Sitam F, Lee C, Japning J, et al. Macacine herpesvirus 1 in long-tailed Macaques, Malaysia, 2009-2011. Emerging Infectious Diseases. 2015;21(7):1107-1113. DOI: 10.3201/eid2107.140162'},{id:"B46",body:'Engel GA, Jones-Engel L, Schillaci MA, Suaryana KG, Putra A, Fuentes A, et al. Human exposure to herpesvirus B-seropositive macaques, Bali, Indonesia. Emerging Infectious Diseases. 2002 Aug;8(8):789-795. DOI: 10.3201/eid0808.010467 PMID: 12141963; PMCID: PMC3266706'},{id:"B47",body:'Elmore D, Eberle R. Monkey B virus (Cercopithecine herpesvirus 1). Comparative Medicine. 2008;58(1):11-21'},{id:"B48",body:'Bryan BL, Espana CD, Emmons RW, Vijayan N, Hoeprich PD. Recovery from encephalomyelitis caused by herpesvirus simiae: Report of a case. JAMA Internal Medicine. 1975;135(6):868-870'},{id:"B49",body:'Eberle R, Jones-Engel L. Questioning the extreme neurovirulence of monkey B virus (Macacinealphaherpesvirus 1). Advances in Virology. 2018;2018:5248420, 17 pages. DOI: 10.1155/2018/5248420'},{id:"B50",body:'Jones-Engel L, May CC, Engel GA, Steinkraus KA, Schillaci MA, Fuentes, A....Linial, M. L. Diverse contexts of zoonotic transmission of simian foamy viruses in Asia. Emerging Infectious Diseases. 2008;14(8):1200-1208. DOI: 10.3201/eid1408.071430'},{id:"B51",body:'Jones-Engel L, Steinkraus KA, Murray SM, Engel GA, Grant R, Aggimarangsee N, et al. Sensitive assays for simian foamy viruses reveal a high prevalence of infection in commensal, free-ranging Asian monkeys. Journal of Virology. 2007;81(14):7330-7337. DOI: 10.1128/JVI.00343-07'},{id:"B52",body:'Hussin N, Lim YAL, Goh PP, et al. Updates on malaria incidence and profile in Malaysia from 2013 to 2017. Malaria Journal. 2020;19:55. DOI: 10.1186/s12936-020-3135-x'},{id:"B53",body:'Yusof R, Lau YL, Mahmud R, Fong MY, Jelip J, Ngian HU, et al. High proportion of knowlesi malaria in recent malaria cases in Malaysia. Malaria Journal. 2014 May;3(13):168. DOI: 10.1186/1475-2875-13-168 PMID: 24886266; PMCID: PMC4016780'},{id:"B54",body:'Singh B, Daneshvar C. Plasmodium knowlesi malaria in Malaysia. The Medical Journal of Malaysia. 2010;65(3):166-172 PMID: 21939162'},{id:"B55",body:'Rahim MAFA, Munajat MB, Idris ZM. Malaria distribution and performance of malaria diagnostic methods in Malaysia (1980-2019): A systematic review. Malaria Journal. 2020;19:395. DOI: 10.1186/s12936-020-03470-8'},{id:"B56",body:'Kurniawati DA, Suwanti LT, Lastuti NDR, Kusdarto S, Suprihati E, Mufasirin M, et al. Zoonotic potential of gastrointestinal parasite in long-tailed Macaque Macaca fascicularis at Baluran National Park, Situbondo, East Java. Indonesia. Aceh Journal of Animal Science. 2020;5(1):47-56. DOI: 10.13170/ajas.5.1.15397'},{id:"B57",body:'Damrongsukij P, Doemlim P, Kusolsongkhrokul R, Tanee T, Petcharat P, Siriporn B, et al. One health approach of melioidosis and gastrointestinal parasitic infections from Macaca fascicularis to human at Kosumpee Forest Park, MahaSarakham, Thailand. Infect Drug Resist. 2021;15(14):2213-2223. DOI: 10.2147/IDR.S299797 PMID: 34163186; PMCID: PMC8214530'},{id:"B58",body:'Adrus M, Zainudin R, Ahamad M, Jayasilan MA, Abdullah MT. Gastrointestinal parasites of zoonotic importance observed in the wild, urban, and captive populations of non-human primates in Malaysia. Journal of Medical Primatology. 2019;48(1):22-31. DOI: 10.1111/jmp.12389 Epub 2018 Oct 29. PMID: 30370934'},{id:"B59",body:'Choong SS, Mimi Armiladiana M, Ruhil HH, Peng TL. Prevalence of parasites in working pig-tailed Macaques (Macaca nemestrina) in Kelantan, Malaysia. J Med Primatol. 2019;48(4):207-210. DOI: 10.1111/jmp.12416'},{id:"B60",body:'Karuppannan KV, Saaban S, Firdaus Ariff AR, Mustapa AR. Non-surgical castration in controling long tailed macaque (Macaca fascicularis) population by Deparatment of Wildlife and National Parks (DWNP) Peninsular Malaysia. Malaysian Journal of Veterinary Research. 2013;4(1):33-36'},{id:"B61",body:'Takeshita RSC, Huffman MA, Kinoshita K, Bercovitch FB. Effect of castration on social behavior and hormones in male Japanese macaques (Macaca fuscata). Physiology & Behavior. 2017;181:43-50'},{id:"B62",body:'Wang Q, Kessler MJ, Kensler TB, Dechow PC. The mandibles of castrated male rhesus macaques (Macaca mulatta): The effects of orchidectomy on bone and teeth. American Journal of Physical Anthropology. 2016;159(1):31-51. DOI: 10.1002/ajpa.22833'},{id:"B63",body:'Kumar V, Kumar V. Clinical evaluation of laparoscopic sterilization techniques in female Rhesus Macaques (Macaca mulatta). Archives of Veterinary Science. 2012;17(3):20-26'},{id:"B64",body:'Yu PH, Weng CC, Kuo HC, Chi CH. Evaluation of endoscopic salpingectomy for sterilization of female Formosan macaques (Macaca cyclopis). American Journal of Primatology. 2014;77(4):359-367. DOI: 10.1002/ajp.22354'},{id:"B65",body:'Lappan S, Ruppert N. Primate research and conservation in Malaysia. CAB Reviews. 2018;14(4):1-10'},{id:"B66",body:'Holzner A, Balasubramaniam KN, Weiß BM, et al. Oil palm cultivation critically affects sociality in a threatened Malaysian primate. Scientific Reports. 2021;11:10353. DOI: 10.1038/s41598-021-89783-3'},{id:"B67",body:'Dzulhelmi MN, Suriyanti S, Manickam S. Population, behaviour and conservation status of long-tailed macaque, Macaca fascicularis and southern pig-tailed macaque, Macaca nemestrina in Paya Bakau Park, Perak, Malaysia. The Journal of Animal & Plant Sciences. 2019;29(2):611-618'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Siew Shean Choong",address:"shean.cs@umk.edu.my",affiliation:'
Faculty of Veterinary Medicine, University Malaysia, Kota Bharu, Kelantan, Malaysia
Faculty of Veterinary Medicine, University Malaysia, Kota Bharu, Kelantan, Malaysia
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