Heuristic components and application domains of hyper‐heuristics for multi‐objective optimization.
\\n\\n
IntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\\n\\nBy listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
\\n\\nAll three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\\n\\n"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\\n\\n"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\\n\\nIn conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\\n\\n“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\\n\\nWe invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\\n\\nFeel free to share this news on social media and help us mark this memorable moment!
\\n\\n\\n"}]',published:!0,mainMedia:{caption:"",originalUrl:"/media/original/237"}},components:[{type:"htmlEditorComponent",content:'
After years of being acknowledged as the world's leading publisher of Open Access books, today, we are proud to announce we’ve successfully launched a portfolio of Open Science journals covering rapidly expanding areas of interdisciplinary research.
\n\n\n\nIntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\n\nBy listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
\n\nAll three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\n\n"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\n\n"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\n\nIn conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\n\n“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\n\nWe invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\n\nFeel free to share this news on social media and help us mark this memorable moment!
\n\n\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"6432",leadTitle:null,fullTitle:"Hyperbaric Oxygen Treatment in Research and Clinical Practice - Mechanisms of Action in Focus",title:"Hyperbaric Oxygen Treatment in Research and Clinical Practice",subtitle:"Mechanisms of Action in Focus",reviewType:"peer-reviewed",abstract:"Hyperbaric oxygen treatment (HBO2) is a widely accepted adjuvant therapy in various health conditions that exhibit impaired tissue blood flow. At high pressures, the delivery of the dissolved oxygen in plasma is enhanced, which contributes to better tissue oxygenation, cellular metabolism and ultimately, healing. However, this is not the only beneficial outcome of HBO2 treatment since oxygen is a highly reactive molecule and can induce upregulation of many enzymatic systems in the cell at the cellular, genetic and molecular level. Particularly, vascular/endothelial function is affected by the HBO2. Our understanding of these mechanisms is still emerging. There have been many controversies related to the HBO2 protocols and indications. As well as exhibiting beneficiary effects on the tissue perfusion, it is known that HBO2 demonstrates high toxicity at higher pressures, due to increased oxidative stress and barotrauma. On the other hand, there is a lack of translation of the knowledge on the mechanisms of action of HBO2 obtained from the experimental research to the clinical practice. Thus, this book presents the reader with an overview of the current knowledge on the mechanisms of HBO2 effects in various experimental models and clinical treatment protocols, in an attempt to provide a better understanding of how and when HBO2 should be used as an effective therapy without unwanted side effects.",isbn:"978-1-78923-599-9",printIsbn:"978-1-78923-598-2",pdfIsbn:"978-1-83881-469-4",doi:"10.5772/intechopen.70322",price:119,priceEur:129,priceUsd:155,slug:"hyperbaric-oxygen-treatment-in-research-and-clinical-practice-mechanisms-of-action-in-focus",numberOfPages:130,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"574f9e3775c072d689ca7cab789dd590",bookSignature:"Ines Drenjančević",publishedDate:"August 29th 2018",coverURL:"https://cdn.intechopen.com/books/images_new/6432.jpg",numberOfDownloads:7879,numberOfWosCitations:6,numberOfCrossrefCitations:7,numberOfCrossrefCitationsByBook:2,numberOfDimensionsCitations:12,numberOfDimensionsCitationsByBook:2,hasAltmetrics:0,numberOfTotalCitations:25,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"July 6th 2017",dateEndSecondStepPublish:"July 27th 2017",dateEndThirdStepPublish:"December 2nd 2017",dateEndFourthStepPublish:"January 21st 2018",dateEndFifthStepPublish:"March 22nd 2018",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"186048",title:"Prof.",name:"Ines",middleName:null,surname:"Drenjančević",slug:"ines-drenjancevic",fullName:"Ines Drenjančević",profilePictureURL:"https://mts.intechopen.com/storage/users/186048/images/5818_n.jpg",biography:"Ines Drenjančević, MD, PhD is a tenure-track professor of physiology and immunology and Chair of the Dept of Physiology and Immunology, Faculty of Medicine Osijek, University Josip Juraj Strossmayer Osijek. She has obtained her PhD in Physiology at the Medical College of Wisconsin, Milwaukee, Wisconsin, USA (2004); MD degree (1993) and MS degree in clinical immunology and allergology (1997) from the Faculty of Medicine University of Zagreb, Croatia. Her research has been funded at national and international level. At the moment, she is PI of CSF project and co-leader of the national Scientific Centre of Excellence for Personalized Health Care. Her interests: mechanisms of microvascular reactivity, effects of various diets (high salt intake, functional food, microelements) and hyperbaric oxygenation-with the common denominator of oxygen sensing and metabolism of arachidonic acid.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"4",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"University of Osijek",institutionURL:null,country:{name:"Croatia"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"177",title:"Emergency Medicine",slug:"emergency-medicine"}],chapters:[{id:"62535",title:"Introductory Chapter: Hyperbaric Oxygen Treatment: Old Treatment with New Understanding",doi:"10.5772/intechopen.79866",slug:"introductory-chapter-hyperbaric-oxygen-treatment-old-treatment-with-new-understanding",totalDownloads:801,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:null,signatures:"Ines Drenjančević",downloadPdfUrl:"/chapter/pdf-download/62535",previewPdfUrl:"/chapter/pdf-preview/62535",authors:[{id:"186048",title:"Prof.",name:"Ines",surname:"Drenjančević",slug:"ines-drenjancevic",fullName:"Ines Drenjančević"}],corrections:null},{id:"59727",title:"Therapeutic Mechanisms of Action for Hyperbaric Oxygen on Femoral Head Necrosis",doi:"10.5772/intechopen.75026",slug:"therapeutic-mechanisms-of-action-for-hyperbaric-oxygen-on-femoral-head-necrosis",totalDownloads:1262,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Femoral head necrosis (FHN) is a disease process resulting from inadequate blood perfusion of subchondral bone. While the etiology of this disease is still not fully understood, there are multiple traumatic and atraumatic factors that are associated with the disease. Pathophysiology of the disease is characterized by the death of bone marrow and osteocytes. If left untreated, the disease may progress to joint collapse. While initial stages of the disease are asymptomatic, painful limitation of active and passive motion of the hip is eventually present. The current body of literature cannot identify an optimal treatment protocol for FHN. Postcollapse cases require surgical intervention, core decompression, or total hip arthroplasty. However, current strides in conservative management are being made. One of the possible conservative modalities that may effectively delay hip arthroplasty or even prevent the need for a surgical approach is hyperbaric oxygen (HBO2) therapy. HBO2 increases extracellular oxygen concentration and reduces cellular ischemia and edema by inducing vasoconstriction. Studies have reported radiographic improvement, reduction in pain, and increases in range of motion for early stages of the disease. Hyperbaric oxygen therapy has also been shown to stimulate angiogenesis and enhance osteoclast and osteoblast function for remodeling and repair.",signatures:"Gerardo Bosco, Alex Rizzato, Giuliano Vezzani, Vincenzo Zanon and\nEnrico Camporesi",downloadPdfUrl:"/chapter/pdf-download/59727",previewPdfUrl:"/chapter/pdf-preview/59727",authors:[{id:"63693",title:"Prof.",name:"Enrico",surname:"Camporesi",slug:"enrico-camporesi",fullName:"Enrico Camporesi"},{id:"217606",title:"Associate Prof.",name:"Gerardo",surname:"Bosco",slug:"gerardo-bosco",fullName:"Gerardo Bosco"},{id:"243195",title:"MSc.",name:"Alex",surname:"Rizzato",slug:"alex-rizzato",fullName:"Alex Rizzato"},{id:"243196",title:"Dr.",name:"Giuliano",surname:"Vezzani",slug:"giuliano-vezzani",fullName:"Giuliano Vezzani"},{id:"243197",title:"Dr.",name:"Vincenzo",surname:"Zanon",slug:"vincenzo-zanon",fullName:"Vincenzo Zanon"}],corrections:null},{id:"59900",title:"Hyperbaric Oxygen Therapy in Traumatic Brain Injury: Cellular and Molecular Mechanisms",doi:"10.5772/intechopen.75025",slug:"hyperbaric-oxygen-therapy-in-traumatic-brain-injury-cellular-and-molecular-mechanisms",totalDownloads:1312,totalCrossrefCites:1,totalDimensionsCites:3,hasAltmetrics:0,abstract:"Traumatic brain injuries (TBI) are among the leading causes of death and chronic disability worldwide. TBI is a complex process encompassing primary injury to the brain tissue and cerebral vasculature induced by the initial impact, secondary injury, including cascade of subsequent neuroinflammatory processes, and regenerative responses with enhanced neurogenesis and angiogenesis. To date, there remains no approved pharmacological therapy that is able to prevent the secondary injury. Therefore, the development of safe and efficacious neuroprotective treatments currently represents the greatest unmet need in the management of TBI. Increasing number of experimental and clinical studies present convincing evidence that hyperbaric oxygen therapy (HBOT), as an adjunctive therapy, may be the suitable neurotherapeutic method for improving neurological outcome after TBI. Irrespective to treatment protocol HBOT appeared to alleviate the detrimental and neurotoxic effects of pathological sequel initiated by TBI and to stimulate endogenous reparative mechanisms. However, the exact mechanisms by which HBOT exerts its beneficial effects on recovery after brain injury are still deficient. In this review we will summarize up to date results of HBOT in experimental and clinical TBI and try to put more light on cellular and molecular mechanisms underlying beneficial effects of HBOT on functional recovery after brain injury.",signatures:"Sanja Pekovic, Sanja Dacic, Danijela Krstic, Rada Jeremic, Marina\nDjelic and Predrag Brkic",downloadPdfUrl:"/chapter/pdf-download/59900",previewPdfUrl:"/chapter/pdf-preview/59900",authors:[{id:"218312",title:"Prof.",name:"Predrag",surname:"Brkic",slug:"predrag-brkic",fullName:"Predrag Brkic"},{id:"218438",title:"Dr.",name:"Sanja",surname:"Pekovic",slug:"sanja-pekovic",fullName:"Sanja Pekovic"},{id:"218609",title:"Dr.",name:"Sanja",surname:"Dacic",slug:"sanja-dacic",fullName:"Sanja Dacic"},{id:"218611",title:"BSc.",name:"Rada",surname:"Jeremic",slug:"rada-jeremic",fullName:"Rada Jeremic"},{id:"218614",title:"Prof.",name:"Marina",surname:"Djelic",slug:"marina-djelic",fullName:"Marina Djelic"},{id:"238176",title:"Prof.",name:"Danijela",surname:"Krstic",slug:"danijela-krstic",fullName:"Danijela Krstic"}],corrections:null},{id:"60271",title:"Microcirculation and Hyperbaric Oxygen Treatment",doi:"10.5772/intechopen.75609",slug:"microcirculation-and-hyperbaric-oxygen-treatment",totalDownloads:1257,totalCrossrefCites:2,totalDimensionsCites:4,hasAltmetrics:0,abstract:"The microcirculation is anatomical and consists of arterioles, capillaries, and venules that perform metabolic requirements and oxygen distribution to the tissues. During physiological or pathological stress, it balances between the oxygen delivery and the demand. This delicate balance can play an important role in the progression of critical illnesses and has a role in the development of organ dysfunction. Reduced microvascular perfusion is seen in many diseases, and hyperbaric oxygen treatment (HBOT) has potentially beneficial effects on the microcirculatory environment. It has been shown that HBOT improves microcirculation independent from systemic hemodynamic parameters, which is a key therapeutic target in the critically ill patient. HBOT is emerging as an adjunct to traditional surgery and antibiotic therapy for the special kinds of problematic wounds or purpura fulminans, which are caused by meningococcal sepsis. HBOT also can increase oxygen supply to the ischemic tissue to reduce the extent of irreversible tissue damage in ischemic stroke, femoral head necrosis, diabetic foot ulcer, and carbon monoxide intoxication. In this chapter, we aim to describe microcirculation with its monitoring systems and to show the effectiveness of HBOT in different clinical settings, which are related to microcirculatory dysfunction.",signatures:"Fethi Gul, Omer Faruk Boran and Reyhan Arslantas",downloadPdfUrl:"/chapter/pdf-download/60271",previewPdfUrl:"/chapter/pdf-preview/60271",authors:[{id:"215553",title:"Dr.",name:"Fethi",surname:"Gul",slug:"fethi-gul",fullName:"Fethi Gul"},{id:"227505",title:"Dr.",name:"Reyhan",surname:"Arslantas",slug:"reyhan-arslantas",fullName:"Reyhan Arslantas"},{id:"238186",title:"Dr.",name:"Omer Faruk",surname:"Boran",slug:"omer-faruk-boran",fullName:"Omer Faruk Boran"}],corrections:null},{id:"60024",title:"Cell Culture Effects of Altered Oxygen Levels and Hyperbaric Treatment In Vitro",doi:"10.5772/intechopen.75378",slug:"cell-culture-effects-of-altered-oxygen-levels-and-hyperbaric-treatment-in-vitro",totalDownloads:1119,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Hyperbaric oxygen therapy (HBOT) is a state-of-the-art medical treatment, which is proved to be beneficial in a number of diseases and promising in new fields as well. HBOT is evidence-based treatment for, among others, severe CO intoxication, decompression disease and chronic wound healing. Recent studies promise beneficial effects of HBOT in multiple sclerosis. In vitro, cellular models of these complex pathological conditions are limited. In this chapter, we aim to mirror in vitro effects of HBOT and other altered oxygen levels on endothelial cells, fibroblast, mesenchymal and pluripotent stem cells. Through these in vitro models, the role of HBOT in angiogenesis, blot clotting, wound healing, cell therapy and tissue engineering will be discussed. To summarize in vitro effects of HBOT, it has beneficial role on proliferation and viability of most cell types. Furthermore, functional characteristics of the investigated cell types, for example, angiogenesis by endothelial cells, are improved in response to HBOT. Standardized preclinical protocols with HBOT help to translate the benefits to clinical trials and clinical use.",signatures:"Edit Gara",downloadPdfUrl:"/chapter/pdf-download/60024",previewPdfUrl:"/chapter/pdf-preview/60024",authors:[{id:"198479",title:"Ph.D.",name:"Edit",surname:"Gara Dr",slug:"edit-gara-dr",fullName:"Edit Gara Dr"}],corrections:null},{id:"61293",title:"Mechanisms of HBO-Induced Vascular Functional Changes in Diabetic Animal Models",doi:"10.5772/intechopen.76569",slug:"mechanisms-of-hbo-induced-vascular-functional-changes-in-diabetic-animal-models",totalDownloads:989,totalCrossrefCites:2,totalDimensionsCites:2,hasAltmetrics:0,abstract:"The mechanisms by which HBO exerts its potentially beneficial effects are not completely clear. Interactions of mechanisms affecting endothelial dysfunction, NO synthesis, EETs and HETE formation, CYP expression changes, oxidative stress and antioxidant defense system changes, and multiple effects on inflammation take place that might be considered as mediating factors for the observed positive (or negative) clinical effects in diabetes mellitus (for instance in chronic diabetic wounds). Studies on vasculature in diabetic animal models can provide us with more information that can help us understand its effects on blood vessel function. This chapter discusses the most relevant studies that have assessed the potential mechanisms of HBO-induced vascular functional changes in diabetic animal models.",signatures:"Ivana Jukic, Mihael Mišir, Martina Mihalj, Zrinka Mihaljevic, Sanela\nUnfirer, Dijana Kibel and Aleksandar Kibel",downloadPdfUrl:"/chapter/pdf-download/61293",previewPdfUrl:"/chapter/pdf-preview/61293",authors:[{id:"183303",title:"Dr.",name:"Aleksandar",surname:"Kibel",slug:"aleksandar-kibel",fullName:"Aleksandar Kibel"},{id:"216257",title:"Dr.",name:"Ivana",surname:"Jukić",slug:"ivana-jukic",fullName:"Ivana Jukić"},{id:"216262",title:"Prof.",name:"Martina",surname:"Mihalj",slug:"martina-mihalj",fullName:"Martina Mihalj"},{id:"250064",title:"Dr.",name:"Mihael",surname:"Misir",slug:"mihael-misir",fullName:"Mihael Misir"},{id:"250066",title:"Dr.",name:"Zrinka",surname:"Mihaljevic",slug:"zrinka-mihaljevic",fullName:"Zrinka Mihaljevic"},{id:"250067",title:"Dr.",name:"Sanela",surname:"Unfirer",slug:"sanela-unfirer",fullName:"Sanela Unfirer"},{id:"250068",title:"Dr.",name:"Dijana",surname:"Kibel",slug:"dijana-kibel",fullName:"Dijana Kibel"}],corrections:null},{id:"61952",title:"Toxic Effects of Hyperbaric Conditions",doi:"10.5772/intechopen.78392",slug:"toxic-effects-of-hyperbaric-conditions",totalDownloads:1139,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Hyperbaric oxygen therapy is highly safe in treatments based on internationally accepted treatment tables. However, in some long-term treatments, the internal adjuvant and the patient are exposed to some toxic effects. In the presence of compressed air environment, nitrogen can lead to drunkenness. Another cause of poisoning is oxygen. Oxygen shows toxic effects when inhaled in the high-pressure environment for long periods or above partial pressures on 3 ATA. The excess oxygen has a toxic effect on the lung and central nervous system (CNS). Oxygen poisoning can be seen in long-term oxygen therapy in intensive care, in closed or semi-closed circuit diving, in saturation dives, on decompressions on the surface, in recompression and hyperbaric oxygen therapy. The first goal during convulsion is to prevent trauma prevent the patient from biting his tongue during the seizure. However, in nitrogen narcosis, the first intervention should be to prevent the diver from diving deeper to reduce the effect of anesthesia. 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Many real‐world problems are complex. Owing to the (often) NP‐hard nature of such problems, researchers and practitioners frequently resort to problem‐tailored heuristics in order to obtain a reasonable solution within a reasonable amount of time. Hyper‐heuristics are methodologies that operate on a search space of heuristics rather than directly searching the solution space for solving hard computational problems. One of the main aims of hyper‐heuristics is to raise the level of generality of search methodologies and to automatically adapt the algorithm by combining the strength of each heuristic and making up for the weaknesses of others. References to multi‐objective hyper‐heuristics are scarce as most research in this area has been limited to single‐objective optimization. The purpose of this chapter is to provide an introduction to hyper‐heuristic methodologies that are designed for multi‐objective optimization (HHMOs). The chapter might help researchers and PhD students interested in this research area to understand and use these methods. Hyper‐heuristics for multi‐objective optimization is a relatively new area of research in operational research (OR) and evolutionary computation [1, 2]. Few studies have dealt with hyper‐heuristics for multi‐objective problems. In order to offer a better understanding of the subject, the basic concepts of multi‐objective optimization and hyper‐heuristics are provided in Section 2. This chapter also provides a brief survey of hyper‐heuristic methodologies that address multi‐objective optimization in Section 3. Some design issues related to the development of a hyper‐heuristic framework for multi‐objective optimization are discussed in Section 4. Additionally, a case study of multi‐objective selection hyper‐heuristics and its application on a real‐world problem is presented in Section 5. Finally, promising research areas for future application are provided in Section 6.
\nAn MOP minimizes \n
In this class, the objective preferences or weights are set by the decision maker prior to the search process. An example of this is aggregation‐based approaches such as the weighted sum approach.
The search is conducted to find solutions for the objective functions. Following this, a decision process selects the most appropriate solutions (often involving a trade‐off). Multi‐objective evolutionary optimization (MOEA) techniques, whether non‐Pareto‐based or Pareto‐based, are examples of this class.
In this class, the preferences of the decision maker(s) are made and adjusted during the search process.
A vector \n
All non‐dominated solutions are also known as the
The main aim of the hyper‐heuristic methodology is raising the level of generality of search techniques by producing general search algorithms that are applicable for solving a wide range of the problems in different domains [2, 8, 9]. In a hyper‐heuristic approach, different heuristics (or heuristic components) can be selected, generated, or combined to solve a given optimization problem in an efficient way. Since each heuristic has its own strengths and weaknesses, one of the aims of hyper‐heuristics is to automatically inform the algorithm by combining the strength of each heuristic and making up for the weaknesses of others. This process requires the incorporation of a learning mechanism into the algorithm to adaptively direct the search at each decision point for a particular state of the problem or the stage of search. It is obvious that the concept of hyper‐heuristics has strong ties to operational research (OR) in terms of finding optimal or near‐optimal solutions to computational search problems. It is also firmly linked to artificial intelligence (AI) in terms of machine‐learning methodologies [8].
\nIn their simplest form, hyper‐heuristics is a search methodology that encompasses a high‐level strategy (which could be a meta‐heuristic) that controls the search over a set of heuristics (low‐level heuristics) rather than controlling a search over a direct representation of the solutions. Usually, in a hyper‐heuristic framework, there is a clear separation between high‐level strategy and the set of low‐level heuristics [10]. The purpose of domain barrier is to give the hyper‐heuristics a higher level of abstraction. This also increases the level of generality of hyper‐heuristics by enabling its application to a new problem without the need for a framework change. Only information relevant to the problem domain is provided from low level to high level, including cost/fitness measured by an evaluation function, indicating the quality of a solution. The high‐level strategy can be a (meta‐) heuristic or a learning mechanism. The task of the high‐level strategy is to guide the search intelligently and adapt according to the success/failure of the low‐level heuristics or combinations of heuristic components during the search process.
\nGenerally, there are two recognized methodologies of hyper‐heuristics:
In the context of hyper‐heuristics for multi‐objective optimization, we could classify them into three categories:
\nThe hyper‐heuristics for multi‐objective optimization problems is a new area of research in evolutionary computation and operational research [2, 8]. To date, few studies have been identified that deal with hyper‐heuristics for multi‐objective problems (see Table 1).
\nComponent name | \nApplication domain/test problems | \nReference(s) | \n
---|---|---|
Tabu search | \nSpace allocation, timetabling | \n[8] | \n
Traveling salesman problems | \n[35] | \n|
Markov chain, evolution strategy | \nReal‐world water distribution networks design/DTLZ, WFG | \n[12] | \n
NSGAII | \nIrregular 2D cutting stock | \n[37] | \n
Strip packing and cutting stock | \n[39] | \n|
NSGAII, quasi‐Newton algorithm | \nStacked neural network | \n[40] | \n
Number of operations from NSGAII, SPEA2, and IBEA | \nA number of continuous multi‐objective test problems | \n[19] | \n
Number of selection, crossover, and mutation operations of evolutionary algorithms | \nSoftware module clustering | \n[23] | \n
Hypervolume | \nDynamic‐mapped island‐based model/WFG | \n[36] | \n
Particle swarm optimization, adaptive metropolis algorithm, differential evolution | \nWater resource problems/a number of continuous multi‐objective test problems | \n[41] | \n
Memory strategy, genetic and differential operators | \nDynamic optimization problems/a number of continuous multi‐objective test problems | \n[46] | \n
Genetic algorithm, simulated annealing, particle swarm optimization | \nEngineering system design problems/a number of classical multi‐objective test problems | \n[16] | \n
Simulated annealing | \nShelf‐space allocation | \n[34] | \n
NSGAII, SPEA2,MOGA, choice function, great deluge algorithm, and late acceptance | \nWFG/the vehicle crashworthiness design problem | \n[24–26] | \n
NSGAII, SPEA2, IBEA, choice function, great deluge algorithm | \nWFG/wind farm layout optimization | \n[32] | \n
Markov model | \nDTLZ | \n[33] | \n
Heuristic components and application domains of hyper‐heuristics for multi‐objective optimization.
Regarding multi‐objective selection hyper‐heuristics, a multi‐objective hyper‐heuristic tabu search (TS) based (TSRoulette Wheel) was presented in Ref. [11]. In this approach, an appropriate heuristic is selected at each iteration using tabu search as a high‐level search strategy. The experiments showed results with acceptable solution when applied in space allocation and timetabling problems. In Ref. [12], an online selection hyper‐heuristic, Markov‐chain‐based hyper‐heuristic (MCHH), is investigated. The Markov chain guides the selection of heuristics and applies online reinforcement learning to adapt transition weights between heuristics. In MCHH, hybrid meta‐heuristics and evolution strategies were incorporated and applied to the DTLZ test problems [13] and compared to a (1+1) evolution strategy meta‐heuristic, a random hyper‐heuristic, and TSRoulette Wheel [11]. The comparison shows the efficacy of the proposed approach in terms of Pareto convergence and learning ability to select good heuristic combinations. Further work is needed in terms of diversity‐preserving mechanisms. The MCHH was applied to the Walking Fish Group (WFG) test problems [14], and although the results from the performed tests show the ability of the approach, future work needs to be made to improve the search strategies [12]. MCHH has been applied to real‐world water distribution networks and it produced competitive results [15]. A multi‐objective hyper‐heuristic optimization scheme for engineering system designs is presented in Ref. [16]. Simulated annealing (SA) [17], genetic algorithm, and particle swarm optimization [18] are used as low‐level heuristics. A multi‐ indicator hyper‐heuristics for multi‐objective optimization is proposed in Ref. [19]. The approach based on multiple rank of indicators is taken from NSGAII [20], SPEA2 [22], and IBEA [21]. In Ref. [23], a multi‐objective hyper‐heuristic genetic algorithm (MHypGA) for multi‐objective software module clustering problem is presented. In MHypGA, different strategies of selection, crossover, and mutation operations of genetic algorithms are incorporated as low‐level heuristics. In Refs. [24–26], online‐learning multi‐objective hyper‐heuristics are presented. These multi‐objective hyper‐heuristics are based on a choice function. The multi‐objective choice‐function‐based hyper‐heuristics are combined with different move‐acceptance strategies including all‐moves (AMs) and the great deluge algorithm (GDA) [27] and late acceptance (LA) [28]. The multi‐objective hyper‐heuristic controls and combines the strengths of three well‐known multi‐objective evolutionary algorithms (NSGAII [20], SPEA2 [22], and MOGA [30]). The performance of the proposed multi‐objective choice‐function‐based hyper‐heuristics is evaluated on the Walking Fish Group (WFG) test suite [14] and is applied to the vehicle crashworthiness design problem [31]. The results of both benchmark test problems demonstrate the capability and potential of the multi‐objective hyper‐heuristic approaches in solving continuous multi‐objective optimization problems. More details about these approaches are provided as a study case in Section 5. In Ref. [32], a multi‐objective selection hyper‐heuristics for a multi‐objective wind farm layout optimization is proposed. The experiential results show that the proposed approach is successfully applied to this optimization problem. In Ref. [33], a multi‐objective selection sequence‐based hyper‐heuristic (MOSSHH) is proposed. The MOSSHH algorithm employs a hidden Markov model based on a sequence of heuristics that is determined by transition probabilities on ɛ‐dominance. The proposed approach has been applied to DTLZ test problems [13] and results showed its capability to solve it through the learning process. A multiple neighborhood hyper‐heuristic for two‐dimensional (2D) shelf‐space allocation problem is proposed in Ref. [34]. The proposed hyper‐heuristic is based on a simulated annealing algorithm. A two‐stage multi‐objective hyper‐heuristic approach is presented in Ref. [35]. The first phase targets in producing an efficient Pareto front, and the second phase focuses on solving a given problem in a flexible way so as to drive a subset of the population to the desired Pareto front. The approach was assessed on the multi‐objective‐traveling salesman problems using 11 low‐level heuristics. Comparison with other methods from the scientific literature revealed that the proposed approach produces high‐quality results. Nevertheless, upcoming efforts are still necessary in advancing the approach. In Ref. [36], a hypervolume‐based hyper‐heuristic for a dynamic‐mapped multi‐objective island‐based model is proposed. This method shows its superiority when compared to the contribution‐based hyper‐heuristic and other standard parallel models over the WFG test problems [14]. A new hyper‐heuristic based on the multi‐objective evolutionary algorithm NSGAII [20] is proposed in Ref. [37]. The main idea of this method involves the production of the final Pareto‐optimal set, through a learning process that evolves combinations of condition‐action rules based on NSGAII. The proposed method was tested on many instances of irregular 2D‐cutting stock benchmark problems and produced promising results. A hyper‐heuristic‐based codification is proposed in Refs. [38, 39], for solving strip packing and cutting stock problems in order to maximize the total profit and minimize the total number of cuts. The experimental results show that outcomes of the proposed hyper‐heuristic outperform single heuristics. In Ref. [40], a multi‐objective hyper‐heuristic for the design and optimization of a stacked neural network is proposed. The proposed approach is based on NSGAII [20] combined with a local search algorithm (Quasi‐Newton algorithm).
\nRegarding multi‐objective hybridization hyper‐heuristic, an adaptive multi‐method (multi‐point) search called AMALGAM is proposed in Ref. [41]. It employs multiple search algorithms, NSGAII [20], PSO [18], AMS [42], and DE [43], simultaneously using the concepts of multi‐method search and adaptive offspring creation. AMALGAM has been applied to a number of continuous multi‐objective test problems, and it has been shown to be superior to other methods. It has also been applied to solve a number of water resource problems and has yielded very good solutions [44, 45]. A multi‐strategy ensemble, multi‐objective evolutionary algorithm called MS‐MOEA for dynamic optimization, is proposed in Ref. [46]. The approach combines differential operators and different strategies, including strategy and genetic, to adoptively creating offspring and increase the convergence speed. The results show that MS‐MOEA obtains solution with good quality.
\nIt is worth mentioning that multi‐objective hybridization hyper‐heuristics are similar to multi‐objective selection hyper‐heuristics in terms of the incorporation of different algorithms. However, they are different in their concepts. Multi‐objective selection hyper‐heuristic is based on two successive stages: a selection mechanism and an acceptance move strategy. By contrast, multi‐objective hybridization hyper‐heuristics is based on an adaptive creation offspring strategy. In multi‐objective selection hyper‐heuristics, a sequence of heuristics/meta‐heuristics is executed during the search, that is, one heuristic/meta‐heuristic is selected and applied at each stage (iteration/decision point) of the search. The high‐level strategy in hyper‐heuristics evaluates the performance of a set of heuristics/meta‐heuristics in order to improve the population of solutions. By contrast, in multi‐objective hybridization hyper‐heuristics, multiple heuristic/meta‐heuristics run concurrently. Each heuristic/meta‐heuristic produces a different population of offspring, and then, all produced offspring are evaluated to evolve a new population of offspring by an adaptive creation offspring strategy.
\nThe idea of hybridizing a number of algorithms (heuristics) into a hyper‐heuristic framework is straightforward and meaningful. However, many design issues related to the development of hyper‐heuristics for multi‐objective optimization require more attention when designing such a framework to be applicable and effective.
\nThe main components of the hyper‐heuristic framework are low‐level heuristics, selection method, learning mechanism, and move‐acceptance method. The choosing of these components is critical. Each component in the hyper‐heuristic framework plays a significant role in improving the quality of both the search and the eventual solution. The components of the hyper‐heuristic in the context of multi‐objective optimization are discussed as follows.
\nThe choice of appropriate low‐level heuristics is not an easy task. Many questions arise here, what heuristics (algorithms) are suitable for dealing with multi‐objective optimization problems? Are priori approaches or a posteriori approaches more suitable? Are non‐Pareto‐based or Pareto‐based approaches more applicable? The author agrees with many researchers [30, 38, 47–51] that evolutionary algorithms and population‐based methods such as decomposition‐based approaches MOEA/Ds (e.g., [52, 53]) and indicator‐based approaches (e.g., [54, 55] are more suitable in dealing with multi‐objective optimization problems because of their population‐based nature, which means that they can find Pareto optimal sets (trade‐off solutions) in a single run, thus allowing a decision maker to select a suitable compromise solution (with respect to the space of the solutions). In the context of multi‐objective hyper‐heuristics, a decision maker here could be a selection method that decides which is the best low‐level heuristic to select at each decision point (with respect to the space of the heuristics).
\nAs a selection hyper‐heuristic relies on an iterative process, the main questions arising here are what is an effective way to choose an appropriate heuristic at each decision point, and how to choose this heuristic, that is, which criteria can be considered when choosing a heuristic? In single‐objective cases, this criterion is easy to determine by measuring the quality of the solution, such as the objective/cost value and time. However, this is more complex when tackling a multi‐objective problem. The quality of the solution is not easy to assess. There are many different criteria that should be considered, such as the number of non‐dominated individuals and the distance between the non‐dominated front and the POF. To make a simple framework, a higher level of abstraction of the hyper‐heuristics should be considered when designing such a framework. It is not necessary to provide any problem‐specific information, such as the number of objectives or the nature of the solution space to the high‐level strategy. More attention should be given to the performance of the low‐level heuristics. This will boost the intensification element. Therefore, a heuristic with the best performance will be chosen more frequently to exploit the search area. The aim is to achieve a kind of balance between the intensification and diversification when choosing a heuristic. Selection methods based on randomization support only the diversification by exploring unvisited areas of the search space. Reinforcement learning (RL) [56] uses support intensification as a selection method by rewarding and punishing each heuristic based on its performance during the search using a scoring mechanism. An example of good selection method is the choice function, which could provide a balance between intensification and diversification.
\nNot all hyper‐heuristic approaches incorporate a learning mechanism. However, a learning mechanism is strongly linked to the selection method. An example of this is a random hyper‐heuristic classified as an offline‐learning approach [1], because the random selection does not provide any kind of learning. The learning mechanism guides the selection method to which best heuristic should be chosen at each decision point. A best heuristic refers to the heuristic that produces solutions with good quality based on some criteria using performance measurements. It is good to note that the measurement of the quality of the solution for multi‐objective problems requires assessing different aspects of the non‐dominated set in the objective space. In the scientific literature, many performance metrics have been proposed to measure different aspects of the quality and quantity of the resulting non‐dominated set [4, 29, 57].
\nThe selection hyper‐heuristic framework comprises two main stages: selection and move‐acceptance methods. A move‐acceptance criterion can be deterministic or non‐deterministic. A deterministic move‐acceptance criterion produces the same result, given the configuration (e.g., proposed new solution, etc.). Non‐deterministic move‐acceptance criteria may generate a different result even when the same solutions are used for the decision at a same given time. This could be because the move‐acceptance criterion depends on time or it might have a stochastic component while making the accept/reject decision. Examples of deterministic move‐acceptance criteria are all‐moves, only‐improving, and improving & equal. For non‐deterministic move‐acceptance criteria, the candidate solution is always accepted if it improves the solution quality, while worsening solutions can be accepted based on an acceptance function, including GDA [27], LA [28], Monte Carlo [58], and SA [17]. Selection of the move‐acceptance criteria has to be compatible with the selection methods. In the scientific literature, many combinations of the selection method and move‐acceptance criterion have been successfully applied to single‐objective optimization [59]. It could be worth employing them in the context of hyper‐heuristics for multi‐objective optimization.
\nThis study [26] highlights the lack of scientific study that has been conducted in hyper‐heuristics and multi‐objective optimization, investigates the design of a hyper‐heuristic framework for multi‐objective optimization, and develops hyper‐heuristic approaches for multi‐objective optimization (HHMOs) to solve continuous multi‐objective problems. Hyper‐heuristic frameworks generally impose a domain barrier that separates the hyper‐heuristic from the domain implementation along with low‐level heuristics to provide a higher level of abstraction. The domain barrier does not allow any problem‐specific information to be passed to the hyper‐heuristic itself during the search process. The multi‐objective choice‐function‐based hyper‐heuristic framework is designed in this same modular manner (see Figure 1).
\nProposed framework of the hyper‐heuristic choice function based on multi‐objective optimization problems.
One of the advantages of the multi‐objective choice‐function‐based hyper‐heuristic framework is its simplicity. It is also highly flexible, and its components are reusable. Moreover, it is built on an interface that allows other researchers to write their own multi‐objective hyper‐heuristic components easily. Even the low‐level heuristics can be easily changed if required. If new and better‐performing components are found in the future, they can be incorporated. Based on the multi‐objective selection hyper‐heuristic framework, three online‐learning‐selection, choice‐function‐based hyper‐heuristics are proposed: HHMO_CF_AM, HHMO_CF_GDA, and HHMO_CF_LA [24, 25]. The multi‐objective choice‐function‐based hyper‐heuristics control and combine the strengths of three well‐known multi‐objective evolutionary algorithms (NSGAII, SPEA2, and MOGA), which are ‐utilized as the low‐level heuristics. The choice‐function‐selection heuristic acts as a high‐level strategy that adaptively ranks the performance of those low‐level heuristics according to feedback received during the search process, determining which one to call at each decision point. Four performance measurements (algorithm effort (AE), ratio of non‐dominated individuals (RNI) [5], size of space covered (SSC) [60], and uniform distribution of a non‐dominated population (UD) [61]) are integrated into a ranking scheme that acts as a feedback‐learning mechanism to provide knowledge of the problem domain to the high‐level strategy. The multi‐objective choice‐function‐based hyper‐heuristic is combined with different move‐acceptance strategies, including all‐moves (AM) as a deterministic move acceptance and GDA [27] and LA [28] as a non‐deterministic move acceptance. GDA and LA require a change in the value of a single objective at each step, and hence a well‐known hypervolume metric, referred to as D metric, is proposed for their applicability to the multi‐objective optimization problems. The D metric is integrated into the non‐deterministic move‐acceptance criterion in order to convert the multi‐objective optimization to the single‐objective optimization without having to define value weights for the various objectives. For more details about the HHMOs algorithm, see Refs. [24, 25].
\nThe multi‐objective vehicle crashworthiness design problem has only five decision variables and no constraints [31]. The output of the problem provides a wider choice for engineers to make their final design decision based on the Pareto solution space. The decision variables of the problem represent the thickness of five reinforced members around the front as they could have a significant effect on the crash safety. The mass of the vehicle is tackled as the first design objective, while the integration of collision acceleration between \n
Thus, the multi‐objective design of vehicle crashworthiness problem in \n
A set of experiments are conducted over a multi‐objective vehicle crashworthiness design problem as a real‐world problem to evaluate the performance of the multi‐objective choice‐function‐based hyper‐heuristics: HHMO_CF_AM, HHMO_CF_GDA, and HHMO_CF_LA. The performance of three multi‐objective hyper‐heuristics is compared to the well‐known multi‐objective evolutionary algorithm, NSGAII [20]. Five performance metrics are used to measure the quality of the approximation sets from different aspects: (i) RNI [5], (ii) SSC [60], (iii) UD [61], (iv) generational distance (GD) [62], and (v) inverted generational distance (IGD) [63]. In addition, the
The mean performance comparison of AM, GDA, LA, and NSGAII based on the performance metrics (RNI, SSC, UD, GD, and IGD) for solving the vehicle crashworthiness problems is provided in Tables 2 and 3.
\nMethod | \nRNI | \nSSC | \nUD | \n|||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
AVG | \nMIN | \nMAX | \nSTD | \nAVG | \nMIN | \nMAX | \nSTD | \nAVG | \nMIN | \nMAX | \nSTD | \n|
NSGAII | \n1.00 | \n1.00 | \n7.936E+07 | \n4.168E+07 | \n9.587E+07 | \n1.595E+07 | \n0.592 | \n0.532 | \n0.670 | \n0.045 | \n||
AM | \n1.00 | \n1.00 | \n7.381E+07 | \n5.315E+07 | \n9.577E+07 | \n0.585 | \n0.516 | \n0.707 | \n0.050 | \n|||
GDA | \n1.00 | \n1.00 | \n6.294E+07 | \n9.580E+07 | \n1.954E+07 | \n0.555 | \n0.692 | \n|||||
LA | \n1.00 | \n1.00 | \n7.538E+07 | \n4.512E+07 | \n9.550E+07 | \n1.474E+07 | \n0.582 | \n0.302 | \n0.641 | \n0.062 | \n
The performance NSGAII and the selection choice‐function‐based hyper‐heuristics using different move‐acceptance strategies on the vehicle crashworthiness problems with respect to the metrics: the ratio of non‐dominated individuals (RNI), the hypervolume (SSC), and the uniform distribution (UD).
Method | \nGD | \nIGD | \n||||||
---|---|---|---|---|---|---|---|---|
AVG | \nMIN | \nMAX | \nSTD | \nAVG | \nMIN | \nMAX | \nSTD | \n|
NSGAII | \n2.48E‐03 | \n1.46E‐03 | \n4.21E‐03 | \n9.10E‐04 | \n4.156E‐03 | \n1.543E‐03 | \n1.289E‐02 | \n3.859E‐03 | \n
AM | \n2.71E‐03 | \n1.59E‐03 | \n4.06E‐03 | \n7.90E‐04 | \n4.376E‐03 | \n1.738E‐03 | \n1.288E‐02 | \n4.168E‐03 | \n
GDA | \n1.10E‐03 | \n4.28E‐03 | \n1.661E‐03 | \n1.230E‐02 | \n3.075E‐03 | \n|||
LA | \n3.32E‐03 | \n1.70E‐03 | \n6.76E‐03 | \n1.33E‐03 | \n3.604E‐03 | \n1.525E‐03 | \n1.238E‐02 | \n
The performance NSGAII and the selection choice‐function‐based hyper‐heuristics using different move‐acceptance strategies on the vehicle crashworthiness problems with respect to the metrics: the generational distance (GD) and the inverted generational distance (IGD).
For each performance metric, the average, minimum, maximum, and standard deviation values are computed. For all metrics, a higher value indicates better performance, except in GD and IGD, where a lower value indicates better performance. The statistical
Methods | \nMetrics | \n||||
---|---|---|---|---|---|
RNI | \nSSC | \nUD | \nGD | \nIGD | \n|
NSGAII:AM | \nn/a | \n+ | \n± | \n± | \n± | \n
NSGAII:GDA | \nn/a | \n− | \n+ | \n± | \n− | \n
NSGAII:LA | \nn/a | \n+ | \n+ | \n+ | \n− | \n
AM:GDA | \nn/a | \n− | \n− | \n± | \n− | \n
AM:LA | \nn/a | \n− | \n± | \n+ | \n− | \n
GDA:LA | \nn/a | \n+ | \n+ | \n+ | \n± | \n
The
The distribution of the simulation data of the 30 independent runs for the comparison methods with respect to these performance metrics is visualized as box plots, shown in Figure 2. The results indicate that all methods perform similar to each other with respect to the metric of RNI over. GDA exhibits the best performance in the metrics of SSC, GD, and IGD, and it converges better toward the POF than the other methods. GDA also exhibits the best performance in the metric of UD and distributes more uniformly than other methods.
\nBox plots of multi‐objective choice‐function‐based hyper‐heuristics methodologies and NSGAII on the multi‐objective vehicle crashworthiness design problems.
The 50% attainment surface for each method, from the 30 fronts after 3750 generations, is computed and illustrated in Figure 3. GDA appears to generate a good convergence. It can be clearly observed that GDA converges to the best POF with a well‐spread Pareto front as compared to the other approaches. By contrast, AM generates the poorest solutions. NSGAII and LA have similar convergence. In general, the hyper‐heuristics for real‐world multi‐objective problems benefits from the use of a learning heuristic selection method as well as GDA. The results demonstrate the effectiveness of our selection hyper‐heuristics particularly when combined with great deluge algorithm as a move‐acceptance criterion. HHMO_CF_GDA turns out to be the best choice for solving this problem. Although other multi‐objective hyper‐heuristics still produce solutions with acceptable quality in some cases, they could not perform as well as NSGAII. In summary, the results of the real‐world problem demonstrate the capability and potential of the multi‐objective hyper‐heuristic approaches in solving continuous multi‐objective optimization problems.
\nThe 50% attainment surfaces for NSGAII and the three multi‐objective choice‐function‐based hyper‐heuristics (AM, GDA, and LA) after 3750 generations on the multi‐objective design of vehicle crashworthiness problem.
Multi‐objective hyper‐heuristic offers interesting potential research directions in multi‐objective optimization. Some of these promising research areas are recommended as follows:
\nMany heuristic selection methods can be adapted from previous research in single‐objective optimization and can be used for multi‐objective optimization within multi‐objective selection hyper‐heuristic. This process is not a trivial process, requiring elaboration of existing methods and their usefulness in a multi‐objective setting. Furthermore, other acceptance criteria such as simulated annealing (SA) and tabu search (TS) [58] could be employed as a move‐acceptance component within the selection hyper‐heuristic framework for multi‐objective optimization. As those criteria involve many parameters, this methodology would require initial experiments to tune the parameters for multi‐objective settings, such as defining a cooling schedule and an initial temperature for SA and aspiration criterion and tabu tenure for TS.
There are many low‐level heuristics choices possible and, therefore, great scope for research in this area. It would be interesting to employ
It would be interesting to test the level of generality of existing multi‐objective hyper‐heuristic frameworks further on some other problems and domains, including the continuous real‐valued constrained, combinatorial, discrete, and dynamic problems.
Since no studies are found in the scientific literature that address multi‐objective generation hyper‐heuristic, it would be interesting to propose a multi‐objective generation hyper‐heuristic framework. This indicates great scope for research. Many‐generation hyper‐heuristic methodologies have been successfully applied to single‐objective optimization; it would also be interesting to modify them to deal with multi‐objective optimization.
Salmonellosis is a disease of great relevance in terms of public health given the economic and social impact that causes both in developing and highly industrialized countries. Due to its transmission mechanism, it affects hundreds or thousands of people every year and is considered an acute disease of worldwide distribution [1] with variations in the frequency of serotypes from one country to another [2], being notably more frequent in areas that have not reached adequate sanitation and hygiene conditions or that do not have enough resources and public health infrastructure. There is no distinction in the occurrence of salmonellosis by sex, age, or social and economic status with high incidence at the extremes of life, being the most vulnerable groups, children under 5yo, adults over 60 years of age and immunocompromised individuals [3, 4]. On the other hand, it is also a seasonal disease, so incidence is higher on periods of increased environmental temperature like spring and summer, showing a decrease in autumn and winter [5].
The raise in salmonellosis at any part of the world is of maximum relevance. For example, an incidence of 0.78–3.8 million cases per year has been estimated in the United States. Natural reservoir is made up of domestic animals (dogs and cats), wild animals (reptiles such as iguanas and turtles) as well as humans (carriers, convalescent). Transmission is through food (with or without manufacture) and water contaminated with human or animal feces and from individual to individual. Salmonellosis presents as sporadic cases or as outbreaks with variable affectations. Incidence rate is dose-dependent in function of the disseminated serotype and is determined by incubation period, symptoms and severity.
Causative agent of salmonellosis are
Regarding its metabolic characteristics,
Most enteric microorganisms are resistant to inhibition by the action of certain bacteriostatic dyes, the selective media containing these compounds facilitate considerably isolation from fecal samples,
Although controversial and evolving, there is a
Since decades ago, classification of
Surface antigen studies are based on H, O, K and Vi antigens. H is denominated surface or flagellar antigen and participates in host immune response, O (aka somatic antigen) is a lipopolysaccharide located in the cell membrane, K is a capsular antigen and Vi antigen is a subtype of K antigen associated to virulence [9] and the obtention of antisera containing antibodies against all these fractions allows the identification of
In Mexico, for example, a study for the classification and identification of
Clinical manifestations in humans include enteric fevers, acute gastroenteritis and septicemia in extreme cases. Prototypical enteric fevers are caused by
The specific virulence factors are encoded by a group of genes for the formation of pathogenicity islands (SPI), with G + C percentages differing from the average of the bacterial genome. Direct repeats are present at the filament ends, carrying genes that encode mobility factors such as integrases, transposases or insertion sequences and are frequently inserted on tRNA. This suggests that they have been obtained from other species by horizontal transfer or by plasmids. There are numerous genes that participate in the invasion and that are present in salmonellas, genes that code for the synthesis of proteins related to the translocation of effector molecules within the cytoplasm of the host cell. Today, it is known that
Drug resistance and worldwide incidence of
Several types of
Resistance not only by
The origin of Natural and Traditional Medicine is indisputably linked both to human history and to its fight for survival [19]. Written evidence on plants being used as remedies for disease is as ancient as Mesopotamian tablets, and from there, a nearly endless number of registers in all cultures, supports its essential role on human well-being. Currently, traditional medicine has been delineated as the use of products of natural origin for health preservation, having the so-called Natural Products (NPs) at its focus.
NPs are broadly defined as small molecules produced by a living organism. This definition comprises a wide variety of compounds including the synthesized during basic metabolism (primary metabolites) or as by-products of it (secondary metabolites). Lipids, carbohydrates, proteins and nucleic acids are part of the first kind of NPs, while smaller molecules such as alkaloids, tannins, saponins and flavonoids are examples of secondary metabolites. Many of the latter does not seem to have a metabolic or evolutionary function for the parental organism, but regardless to that, its utility as drugs, preservatives, dyes, food additives and/or antibiotics is undeniable. Its application to counteract the pathogenic microorganisms affecting our specie, alongside side-effects and resistance to antibacterial drugs, is undoubtedly enough motivation for the current formalization and systematization of traditional knowledge, with methodological studies being carried out very frequently nowadays.
There has been an important upturn in the study of compounds of natural origin during the last decade, supported on ethnopharmacological information, folkloric reputation, traditional uses and the existence of previous evidence, and also based on NPs chemical composition and its chemotaxonomic classification. This explosion of information has been enriched primarily through the obtention and separation of crude extracts, essential oils, and/or other types of preparations that are subsequently analyzed for possible biological activities of metabolites or secondary products. Modern experimental strategies have included bioassays (mainly in vitro), development of NP libraries, production of active compounds in cell or tissue cultures, genetic manipulation of organisms, natural combinatorial chemistry, etc. [20]. NPs, being originated in living organisms, are essentially complex mixtures contained within cellular structures, hence the first step into the study of its properties is the separation of such structures. This first step is called extraction, and is generally carried out by liquid solvents at room temperature and atmospheric pressure, along with other well-known and widely used techniques such as steam distillation and the use of supercritical fluids or pressurized gases [21]. The proper choice of an extraction step is necessarily based on the nature, origin and composition of the product to be studied, taking into account the characteristics of the possible solvents (innokenty, reactivity, etc.), toxicity of secondary products, product sufficiency needs and evaluation methods to be followed afterwards, as a whole this step should result suitable to fulfill the objective of a research. Second and third steps are the setting of an adequate model for biological efficacy assessment and the elucidation of individual bioactive components.
In this chapter, we enlisted natural products frequently reported against
Parental organism | Extraction method | Segment used | Bioactive compound(s) | Location | Year | Ref | ||
---|---|---|---|---|---|---|---|---|
Lactobacillus plantarum ZJ316 | Bacteria | culture supernatant filtration (methanol/acetonitrile) | bacilli | L-phenyl lactic acid | China | 2020 | [22] | |
Lectin (Bifidobacterium adolescentis) from bee honey | Bacteria | crude and purified extracts | honey | lectin | Iraq | 2019 | [23] | |
Lactobacillus salivarius, L. casei B1, | Bacteria | co-culture | co-culture | not specified | Benin | 2019 | [24] | |
Lactococcus lactis subsp.lactis (CNRZ 1427) | Bacteria | not specified | not specified | specific microbial enzymes, perox-ide, weak organic acids anti-bacterial peptides, secretion of bacteriocins protease production | Algeria | 2014 | [25] | |
Streptomyces spp | Bacteria | crude protein | microbial cells | not specified | India | 2014 | [26] |
Summary of frequently reported natural products from bacteria origin against
Parental organism | Extraction method | Segment used | Bioactive compound(s) | Location | Year | Ref | ||
---|---|---|---|---|---|---|---|---|
Lentinus edodes | Fungus | fermenting/Black rice bran culture | mycelia | bioprocessed polysaccharide | Korea | 2018 | [27] | |
Coriolus versicolor | Fungus | methanolic extract | not specified (probably full fungi body) | phenolics, polysaccharides, β-glucans, α-glucans, proteins | Serbia | 2016 | [28] | |
Pleorotus ostreatus (oyster mushroom) | Fungus | ethanolic extract | not specified (probably full fungi body) | not specified | Germany | 2015 | [29] | |
Ganoderma lucidum | Fungus | ethanolic, methanolic, acetone and aqueous extracts | fruiting bodies | not specified | India | 2010 | [30] | |
Lentinus tuberregium | Fungus | Hexane, Dichloromethane, Chloroform and Ethylacetate extracts | not specified (probably full fungi body) | not specified | India | 2010 | [31] | |
Pichia pastoris X-33 | Yeast | YPD broth supplemented with 1 mg.mL − 1 pancreatin, 0.2% bile salts, and pH adjusted 8 with 0.1 N NaOH | yeast cell | not specified | Brazil | 2015 | [32] |
Summary of frequently reported natural products from fungi origin against
Parental organism | Extraction method | Segment used | Bioactive compound(s) | Location | Year | Ref | ||
---|---|---|---|---|---|---|---|---|
Apitoxin | Animal | crude apitoxin | apitoxin | Melittin, adolapin, apamin or MCD-peptide, phospholipase A2 or hyaluronidase, histamine, epinephrine | Ecuador | 2020 | [33] | |
Apitoxin | Animal | crude apitoxin | apitoxin | Melittin, adolapin, apamin or MCD-peptide, phospholipase A2 or hyaluronidase, histamine, epinephrine | Ecuador | 2019 | [34] | |
Masske butter | Animal | lactic isolates | microbial cells | lactic acid | Iran | 2019 | [35] | |
Propolis | Animal | ethanolic extract | propolis | flavonoids, alkaloids, terpenoids, steroids, saponins, and tannins | Indonesia | 2019 | [36] | |
Sarconesiopsis magellanica | Animal | RP-HPLC | larvae | Sarconesin | Colombia | 2018 | [37] | |
Dadih dadih | Animal | ice cream | buffalo milk yogurt | not specified | Indonesia | 2017 | [38] | |
Donkey’s milk | Animal | no extraction | milk | not specified | Serbia | 2017 | [39] | |
Colla corii asini | Animal | aqueous and ethanolic extracts | donkey-hide gelatin | glycine, alanine, aspartic acid, glutamic acid, β-amino isobutyric acid | Korea | 2017 | [40] | |
Bovine natural antibodies | Animal | antibodies | serum | antibodies | The Netherlands | 2016 | [41] | |
Propolis | Animal | ethanolic extracts | propolis | phenolic acid components. Sinergy with cefixime | India | 2016 | [42] | |
Anguilla spp. | Animal | aqueous dilution | mucus | not specified | Indonesia | 2016 | [43] | |
Propolis | Animal | not specified | propolis | phenolic compounds (flavonoids) | Chile | 2015 | [44] | |
Honeys | Animal | aqueous dilution | honey | not specified | Pakistan | 2015 | [45] | |
Platelet rich plasma | Animal | whole blood | thrombin PRP/CaCl2 PRP | probably antimicrobial peptides | Iran | 2014 | [46] | |
Honey | Animal | aqueous dilution | honey | not specified | Romania | 2014 | [47] | |
Donkey’s milk | Animal | no extraction | milk | not specified | Serbia | 2014 | [48] | |
Propolis | Animal | ethanolic, methanolic and aqueous extracts | propolis | terpenoids, flavonoids, alkaloids, phenols, tannins and saponins | India | 2013 | [49] | |
Slovenian Propolis | Animal | 70% and 96% ethanol | propolis | phenolic compounds (probably a synergy) | Slovenia | 2012 | [50] | |
Shrimp Chitosan | Animal | acetic acid 1% | shrimp | not specified | Bangladesh | 2011 | [51] | |
Honey | animal | saline dilution | honey | not specified | Greece | 2011 | [52] | |
Propolis | Animal | ethanolic extract | propolis | quercetin, chrysin, 4′,5-dihydroxy-7-methoxyflavonone and 3,4′,7-trimethoxyflavonone | Turkey | 2011 | [53] | |
Honey | Animal | aqueous dilution | honey | not specified | India | 2010 | [54] |
Summary of frequently reported natural products from animal origin against
Parental organism | Extraction method | Segment used | Bioactive compound(s) | Location | Year | Ref | ||
---|---|---|---|---|---|---|---|---|
Zanthoxylum Acanthopodium DC | Plant | n-hexane and ethyl acetate extract | Fruit | flavonoids, alkaloids, and saponins | Indonesia | 2020 | [55] | |
Plant | methanol extracts | stem bark | scopoletin | Indonesia | 2020 | [56] | ||
Combre tummicranthum; Acacianilotica and Phyllanthus pentandrus | Plant | aqueous, ethanol and chloroform extracts | leaves | tannins, flavonoids, saponins, sterols, triterpenes, alkaloids, anthocyanes and free anthraquinones | Niger | 2020 | [57] | |
Nauclea latifolia | Plant | ethyl acetate and methanol | leaves | tannins, flavonoids and anthraquinones (all are highly polar and polyphenolic) as secondary metabolites but steroids were absent | Indonesia | 2020 | [58] | |
Plant | ethanolic extracts | leaves | alkaloids, flavonoids and saponins | 2020 | [59] | |||
Biarum bovei (cardin) | Plant | ethanol 50% (ultrasound) | leaves | Nerrel, flavonoids and nercernerrel | Iran | 2020 | [60] | |
Plant | methanol extracts | leaves | alkaloid, flavonoids, tannins, terpenoids, steroids, saponin, phenolic | Indonesia | 2020 | [61] | ||
Plant | flour | leaves | Fructans | Mexico | 2020 | [62] | ||
Plant | methanol, ethyl acetate and n-hexane (chromatography) | leaves | Tannins and flavonoids | Indonesia | 2020 | [63] | ||
Plant | hydro-ethanolic extract followed by chloroform and ethyl acetate | stem bark | maniladiol, scopoletin, ethyl gallate and Gallic acid | Cameroon | 2020 | [64] | ||
Plant | hydro-ethanolic and methanolic extracts | leaves, root and stem bark | Anthocyanins, Flavonoids, Glycosides, Phenols, Tannins, Triterpenoids and Steroids | Cameroon | 2020 | [65] | ||
Plant | methanolic extracts | leaves, fruits and seeds | Quinic acid, p-coumaric acid, rutin and quercitrin | Tunisia | 2020 | [66] | ||
Rhododendron arboreum and | Plant | ethanolic and methanolic extracts | leaves | oleanadien-3β-ethan-3-oate | Nepal | 2020 | [67] | |
Uvaria chamae, | Plant | aqueous and ethanolic extracts | leaves and root | not specified | Benin | 2020 | [68] | |
Plant | hydro-organic extraction (patented) | fruit | HOL: catechin, epicate-chin and isoquercetin. HOP: phologlucinic acid, miquelianin, rutin, inkaempferol and caftaric acid | Spain | 2020 | [69] | ||
Plant | ethanolic extract | peel | not specified | Indonesia | 2020 | [70] | ||
Olive oil | Plant | ethanolic extract | fruit | polyphenol extracts | China | 2020 | [71] | |
Agrimonia pilosa Ledeb, | Plant | aqueous extracts | herb, rhizome, root and tuber | not specified | China | 2020 | [72] | |
Plant | essential oil | fruit | 2,6-octadienal, 3,7-dimethyl-, 2,6-octadien-1-ol, 3,7-dimethyl-, and Z-2,6-octadien-1-ol, 3,7-dimethyl, Z-2,6-Octadienal, 3,7-dimethyl-, Z-citral | China | 2020 | [73] | ||
Plant | aqueous, methanolic and ethanolic extracts | gall, fruit | hexadecanoid acid, 9-octadecenoic acid, octadecenoic acid, 2-tert buil-4-isopropil-5 metylphenol | India | 2020 | [74] | ||
Capparis decidua | Plant | methanolic extract | whole plant | not specified | Pakistan | 2020 | [75] | |
Detarium microcarpum Guill. & Perr. | Plant | ethanolic extract | leaves, twigs, roots, and root bark | flavonoids, sterols, triterpenes, glucosides, coumarins, and saponins | Cameroon | 2020 | [76] | |
Tetrapleura tetraptera | Plant | ethanolic extract | stem | citral, acetic acid, limonene, butanol, 2-hydroxyl-3 butanone, Cis-Verbenol Trans-Verbenol, α-Terpinyl acetate, butanoic acid, 2-methyl butanol | Ghana | 2020 | [77] | |
Plant | aqueous and ethanolic extracts | leaves | alkaloid, tannins, oxalate, flavonoids and essential oil | Nigeria | 2019 | [78] | ||
Aeollanthus pubescens | Plant | essential oil (aqueous) | leaves | thymol and carvacrol (anti-radical activity) | Nigeria | 2019 | [79] | |
Plant | ethanol extracts | flower | secondary metabolites such as alkaloids, phenolic and flavonoid | Indonesia | 2019 | [80] | ||
Plant | N-hexane, ethyl acetate, ethanol | leaves | phenols and flavonoids | Indonesia | 2019 | [81] | ||
Morinda lucida | Plant | acetone and aqueous extracts | leaves | not specified | South africa | 2019 | [82] | |
Zanthoxylum acanthopodium DC (andaliman) | Plant | ethanol extracts | fruit | saponin, tannin, steroid and alkaloid | Indonesia | 2019 | [83] | |
Plant | ethanol extracts | berries and leaves | Phenolic compounds (1-hexanol, eucalyptol and 4-terpenol) | Ecuador | 2019 | [84] | ||
Plant | 70% ethanol, followed by n-hexane, ethyl acetate and water | seeds | alkaloids, flavonoids, terpenoids and saponins | Indonesia | 2019 | [85] | ||
Plant | methanol and aqueous extracts | leaves and stem bark | alkaloid, saponin, phenol, flavonoids, glycoside, anthraquinones, terpenoid and tannin | Nigeria | 2019 | [86] | ||
Plant | ethanol extracts | leaves | Saponin, flavonoids, terpenoid/steroids and tannin | Indonesia | 2019 | [87] | ||
Sesbiana grandiflora L. Press | Plant | 90% ethanol followed by n-hexane, ethyl acetate and aqueous extraction | leaves | Saponin, flavonoids, terpenoid, alkaloids and tannin | Indonesia | 2020 | [88] | |
Plant | aqueous extract | seeds | methane, oxybis [dichloro-, 1H-Cyclopenta [c] furan-3-(3aH)-one,6,6a-dihydro-1-(1,3-dioxolan-2-yl)-,(3aR, 1-t, Octadecane, 6-methyl-, Heptadecane, 2,6,10,14-tetramethyl-, BIS (2-Ethylhextl) phthalate, 4H-Pyran-4-one,2,3-dihydro-3,5-dihydroxy- 6-methyl-, 3,4-Dichlorophenethylamine and 1,4-Benzenediol, 2-bromo- | India | 2020 | [89] | ||
Plant | hydroethanolic extract | leaves | flavones and flavonols (3-hydroxyflavones or flavonols with substituted 3-hydroxyl groups (methylated or glycosylated)) | Brazil | 2019 | [90] | ||
White mustard | Plant | essential oil | essential oil | not specified. Synergic with carvacrol and thymol | USA | 2019 | [91] | |
Plant | 70% ethanol followed by petroleum ether, ethyl acetate, n-butanol and water | valonia and shell | ellagic acid, theophylline, caffeic acid and tannin acid | China | 2019 | [92] | ||
Plant | ethanol, ethylacetate, hexane, dichloromethane and methanol extracts | leaves | not specified | Syria | 2019 | [93] | ||
Ocotea minarum | Plant | 80% ethanol followed by hexane and ethyl acetate | leaves and stem bark | caffeic acid, p-coumaric acid, rosmarinic acid, quercetin and luteolin | Brazil | 2019 | [94] | |
Plant | ethanolic extract | rhizome | Alkaloids, terpenoids, and tannins | Indonesia | 2019 | [95] | ||
Annona muricata | Plant | ethanolic extract | leaves | flavonoids, alkaloids, terpenoids, saponins, coumarins, lactones, | Indonesia | 2019 | [96] | |
Plant | aqueous extracts | fruits, whole plants, leaves, and barks | phenolic acid and flavonoid | China | 2019 | [97] | ||
Pectin of | Plant | aqua, ethanol | Fruit peel | oligosaccharides | Cameroon | 2019 | [98] | |
Plant | hexanic, chloroform, methanolic and aqueous extracts | fruits | methylgallate, gallicacid and (2S)-naringenin-7-O-β-glucopyranoside | Mexico | 2019 | [99] | ||
Plant | aqueous, ethanolic and chloroform extract | leaves and stem bark | alkaloid, flavonoids and tannin | Nigeria | 2018 | [100] | ||
Plant | aqueous extract | leaves | saponin, flavonoids, and tannins, glycoside, cardiac glycosides, steroids, saponin glycoside, anthraquinones and volatile oil (trace) | Nigeria | 2018 | [101] | ||
Plant | ethanol extracts (96, 70 and 50%) | fruit | not specified (probably a polar molecule) | Indonesia | 2018 | [102] | ||
Plant | aqueous and ethanol (80%) extracts | peel | alkaloid, tannin, saponin, glycoside, flavonoid, terpenoid, and Phenols | Nigeria | 2018 | [103] | ||
Cinammomum cassia | Plant | Sodium bisulfite (1:1), petroleum ether | oil | cinnamaldehyde | Indonesia | 2018 | [104] | |
Plant | essential oil (aqueous) | not specified | Probably trans-cinamaldehyde, carvacrol, eugenol and acid 2,4 dihydroxybenzoic | Cuba | 2018 | [105] | ||
Jacaranda micrantha | Plant | aqueos and 70% ethanolextract | leaves | phenolic compounds, tannins, flavones and saponins | Brazil | 2018 | [106] | |
Plant | aqueous oil extract | bulb and whole plant | Allicin and thymol | Egypt | 2018 | [107] | ||
Plant | essential oil | bark, bud, flowering plant, leaves and flowers | cinnamaldehyde, linalool, eugenol, eugenyl acetate, b-Caryophyllene, carvacrol, thymol, y-Terpinene, geraniol and p-Cymene. | Spain | 2018 | [108] | ||
Plant | juice (pure extract) | fruit | citric acid, hesperidin, carvacrol and thymol | Korea | 2018 | [109] | ||
Plant | ethanolic extract followed by petroleum ether, dichloromethane (DCM), ethyl acetate (EtAc) and n-Butanol (n-BuOH). Supercritical extract | stem | Kaempferol 3-O-(6”-O-acetylglucoside), 5-O-Caffeoyl shikimic acid, Catechin | Iran | 2018 | [110] | ||
Thymus vulgaris L., Rosmarinus officinalis L. | Plant | essential oils | leaves | a-pinene, Thymol, Oxygenated monoterpenes, monoterpene hydrocarbons, borneol, 1,8-cineole | Morocco | 2018 | [111] | |
Plant (algae) | aqueous, methanolic and ethanolic extracts | whole plant | carvacrol, p-cymene and y-terpinene | Indonesia | 2018 | [112] | ||
Sterculia spp. | Plant | ethanolic extract | bark | flavonoids, alkaloids and saponins | Indonesia | 2018 | [113] | |
Plant | aqueous and methanolic extracts and oil | seed | not specified | Pakistan | 2018 | [114] | ||
Rice hull smoke extract | Plant | pyrolysis of rice hulls followed by liquefaction | hull | 161 components, bioactive unknown | Korea | 2018 | [115] | |
Basil, ginger, hyssop, caraway, juniper, and sage | Plant | essential oils | several | estragole, cis-pinocamphone, alpha-pinene (in juniper EO), a-thujone (in sage EO), carvone (in caraway EO) and curcumene (in ginger EO) | Serbia | 2017 | [116] | |
Plant | ethanolic and methanolic extracts | leaves | flavonoids | Malaysia | 2017 | [117] | ||
Plant | methanolic, ethanolic and acetone extracts | leaves | not specified | India | 2017 | [118] | ||
Plant | methanolic extract | root and leaves | flavonoid, tannins, saponins, cardial glycoside | Nigeria | 2017 | [119] | ||
Plant | acetone, methanolic, acetylacetate and aqueous extracts | berries, leaves, bark and roots | pelargonidin 3,5-diglucoside, naringenin-7-O-β-D-glucoside, tannins, catechins, and cyanidin-3-glucoside, betulin, lupeol, lupenone and friedelin. | South | 2017 | [120] | ||
Plant | acetone extract | bark, leaves, bulb, tuber, root and corms | quercetin-3-O-a-l-arabinopyranoside ( | South Africa | 2017 | [121] | ||
Plant | ethanolic and methanolic extracts | leaves | Alkaloids | Togo | 2017 | [122] | ||
Plant | ethanolic, methanolic, hexanic, acetone, dichloromethanic, ethylacetate and aqueous extracts | leaves | Germacrene-D, a-Panasinsene and b-Selinene | Brazil | 2017 | [123] | ||
Rosmarinus officinalis | Plant | essential oil | not specified | not specified | Iran | 2017 | [124] | |
Myristica fragans | aqueous extracts | seed | methane, oxybis | India | 2017 | [125] | ||
Plant | methanolic extract | leaves | flavonoids, phenolics, and steroids (naringenin) | Indonesia | 2017 | [126] | ||
Vitex doniana | Plant | aqueous and methanolic extracts | stem-bark and leaves | phytochemicals alkaloid, saponin, tannin, anthraquinone, flavonoid, phenols, terpenoid andglycoside | Nigeria | 2017 | [127] | |
Plant | aqueous water | flower calyx | not specified | Mexico | 2017 | [128] | ||
Ziziphora clinopodioides | Plant | essential oil | leaves | nisin | Iran | 2017 | [129] | |
Tinospora cordifolia | Plant | aqueous and methanolic extracts | stem | not specified | India | 2017 | [130] | |
Plant | ethanol extracts | leaves | flavonoids and triterpenoids | Indonesia | 2016 | [131] | ||
Heliotropium filifolium(Miers) Reiche and of Heliotropium sinuatum(Miers) | Plant | resinous exudate (CH2Cl2) and hexane-ethyl acetate step gradient | fresh parts (cuticular components) | (Filifolinol) (naringenin, 3-O-methylgalanginand pinocembrin) | Chile | 2016 | [132] | |
Plant | ethanolic and chloroformic extracts | peel, oak trunk, thyme fruit and cortex | gallocatechins, delphinidin, cyanidin, gallicacid,ellagic acid, pelargonidin and sitosterol; hymol, carvacrol and flavonoids; cynamaldheide; (4,5-Di-o-galloyl (+) –protoquercitol) and compound III (3,5-Di-o-galloyl (+)-protoquercito | Iraq | 2016 | [133] | ||
Scutellariae radix | Plant | ethanol extracts followed by petroleum ether (PEF), chloroform (CF), ethyl acetate (EAF) and n-butanol (BF) | root | baicalin, wogonoside, baicalein and wogonin | China | 2016 | [134] | |
Plant | not specified | aerial and root parts | not specified | Portugal | 2016 | [135] | ||
Holarrhena antidysentrica (Ha) and Andrographis paniculata (Ap) | Plant | hydroethanolic extract | leaves and stem | alkaloids, flavonoids, saponin, terpenes, phenols, tannins, glycosides carotenoids, anthraquinones, reducing sugars, phlobatannins, sterols | India | 2016 | [136] | |
Black tea (Kombucha) | Plant | Infusion/fermentation | leaves | Catechin and isorhamnetin | India | 2016 | [137] | |
Curcuma longa | Plant | 96% ethanol/essential oil | rhizomes | saponin, tannins, alkaloids and flavonoids (probably curcumin and derivatives) | Colombia | 2016 | [138] | |
Harungana madagascariensis | Plant | aqueous infusion | leaves | not specified | Cameroon | 2016 | [139] | |
Plant | 95% ethanol | fruits, root, stem, rhizome, leaves husk, peduncle and wood | Plumbagin, Piperine, Eugenol, Myristicin, Gingerol, Shogaol and Brazilin | Thailand | 2016 | [140] | ||
Punica granatum | Plant | ethanolic extracts and peel flour | peel, seeds | ellagic acid or ellagic acid derivatives, ellagitannins and HHDP-gallagyl-hexoside | Spain | 2016 | [141] | |
Planta | aqueous extracts | leaves, seed and root | steroids, saponins, phenolics, tannins, flavonoids, terpenoids and alkaloids | Nigeria | 2016 | [142] | ||
Piliostigma thonningii | Plant | hexane and aqueous extracts | leaves | Tannins, terpenoids, flavonoids, alkaloids, steroids and phenols | Nigeria | 2015 | [143] | |
Plant | ethyl acetate, acetone, methanol and hydro-ethanol mixture (2: 8) extracts | leaves and stem bark | terpenoids, tannins, flavonoids, phenols, saponins, steroids and cardiac glycosides. | Cameroon | 2015 | [144] | ||
Wood vinegar | Plant | vinegar | natural vinegar | not specified (probably pH 4.15–4.59) | Thailand | 2015 | [145] | |
Aristolochia indica, Carica papaya, | Plant | methanol extracts | leaves | n-Hexadecanoic acid | India | 2015 | [146] | |
Curry: | Plant | water, UHT coconut milk, and fresh coconut milk were used as extractants. Also ethanolic and aquous extracts (Garlic) | fruit, leaves and peel | not specified | Thailand | 2015 | [147] | |
Plant | ethanol extracts | leaves | probably quercetin | Thailand | 2015 | [148] | ||
Eucalyptus, mint, cinnamon, garlic, thymus | Plant | oil | bark and leaves | probably cinnamaldehide/thymol | Egypt | 2015 | [149] | |
Piper crocatum (Red betel vine) | Plant | 70% ethanol, followed by n-hexane, ethyl acetate, chloroform and methanol | leaves | saponin and flavonoids | Indonesia | 2015 | [150] | |
Dionisya revoluta | Plant | methanol extracts | aerial parts | not specified | Iran | 2015 | [151] | |
Plant | methanolic extracts followed by chloroform, n-hexane, n-butanol, ethyl acetate and water | leaves | Phenolic compounds, oils, saponins, flavonoids, alkaloids and tannins | Pakistan | 2015 | [152] | ||
Plant | hydro-ethanolic (80%) and aqueous extracts | not specified | Australia | 2015 | [153] | |||
Citrus sinensis | Plant | ethanol, methanol, chloroform, and diethyl ether | peel | saponins, terpenoids, slkaloids, flavonoids, tannins and cardiac glycosides | Pakistan | 2015 | [154] | |
Nigella sativa | Plant | essential oil | seed | thymoquinone, p-cymene, a-phellandrene, a-pinene, b-pinen, cis-carveol, trans-anethole, thymol, alongipinene and longifolene | Arabia and India | 2015 | [155] | |
Allium sativum L. | Plant | aqueous extracts | bulb | not specified | South Korea | 2015 | [156] | |
Spirulina platensis | Plant (algae) | ethanolic and chloroform extracts | cell extracts | not specified | Bangladesh | 2015 | [157] | |
Curri = Capsicum annuum, Citrus hystrix, Cuminum cyminum L., Allium ascalonicum L., Allium sativum, Cybopogon citratus, Alpinia galangal, ando coconut milk | Plant | not specified | fruit, peel, seed, bulb, stem, rhizome | especificados por compuesto, reportes previos | Thailand | 2015 | [158] | |
Vitex doniana | Plant | ethanolic and Acetone extracts | leave, stem bark and root | tannin, saponins, flavonoid, carbohydrate, glycoside, protein and steroid | Nigeria | 2015 | [159] | |
Polygonum odoratum | Plant | essential oil | leaves | Dodecanal 55.49%, Decanal 11.57%, Pentacosane 7.26%, p-Anis aldehyde 6.35% mainly | Thailand | 2015 | [160] | |
Kelussia odoratissima | Plant | aqueous and ethanolic extracts | leaves | not specified | Iran | 2014 | [161] | |
Coptidis rhizoma (CR), Houttuyniae herba, Taraxaci herba, Glycyrrhizae radix, Puerariae radix, and Rhizoma dioscoreae | Plant | aqueous infusion | herbs | berberine, ginsenoside Rb1, and glycyrrhizin | China | 2014 | [162] | |
Nymphea tetragona | Plant | 50% methanol followed by dichloromethane, ethyl acetate, and butanol | body and root | DFNTE: hydrocarbons (46.46%); EFNTE: methyl gallate (70.44%), 1, 2, 3-benzenetriol or pyrogallol (20.61%), and 6, 8-dimethylbenzocyclooctene (5.90%); BFNTE: 2-hydrazinoquinoline (57.61%), pyro-gallol (20.09%), and methyl gallate (12.77%) | Korea | 2014 | [163] | |
Virgin coconut oil and palm kernel oil | Plant | essential oil | fruit and seed | not specified | Indonesia | 2014 | [164] | |
Virgin Coconut Oil | Plant | oil | fruit | not specified | Indonesia | 2014 | [165] | |
Piper nigrum L. | Plant | ethanolic extracts and chloroform extracts | fruit and seed | tannins, alkaloids and Cardiac glycosides, and tannins, alkaloids and flavonoids | India | 2014 | [166] | |
Plant | hydromethanolic and aqueous extracts | leaves and stem | phenolics and flavonoids | Tunisia | 2014 | [167] | ||
Plant | ethanolic, methanolic and aquous extracts | stem bark | saponins, tannins, reducing sugar, aldehyde, phlobatannins, flavonoids, terpenoids, alkaloids, cardiac glycoside and anthroquinones | Nigeria | 2014 | [168] | ||
Plant | Ethanolic extracts | leaves | not specified | Iran | 2014 | [169] | ||
Palm oil (Sania), Virgen coconut oil (Palem Mustika) and soybean oil (Mama Suka) | Plant | oils | seeds and fruits | not specified | Indonesia | 2014 | [170] | |
Heliotropium | Plant | methanolic extract, 2nd extraction with petroleum ether, ethylacetate and chloroform and aqueous | aerial parts | not specified | Iran | 2014 | [171] | |
Woad, heartleaf houttuynia herb, baical skullcap, coptidis, andrographitis, | Plant | aqueos extract | bark, leaves, root, rhizome and fruit | not specified | China | 2013 | [172] | |
Plant | methanolic extract | bark, leaves and seed | not specified | Sudan | 2013 | [173] | ||
Phylanthus amarus | Plant | aqueous and ethanolic extracts | leaves | Phyllanthin, Nirtetralin, Linalool, phytol | India | 2013 | [174] | |
Carissa opaca | Plant | 95% methanol followed by n-hexane, ethyl acetate, chloroform, butanol and water | fruits | orientin, isoquercetin, myricetin and apigenin (and probably other secondary metabolites) | Pakistan | 2013 | [175] | |
Plant | acetone extract | leaves | mangiferin | Pakistan | 2013 | [176] | ||
Plant | essential oil | seeds | 4-hydroxybenzyl isothiocyanate | USA | 2013 | [177] | ||
Origanum vulgare | Plant | essential oil | seed | not specified | USA | 2013 | [178] | |
Annona comosus and Citrus senensis | Plant | ethanolic extract | peel | alkaloids, flavonoids, saponins, tannins | Nigeria | 2013 | [179] | |
Carthamus nctoricus L., Poncirus trifollata Raf., Scutellaria balcalensis Georgi, Prunus sargentii, | Plant | ethanolic extract | leaves, peel | not specified | Korea | 2013 | [180] | |
Herba pogostemonis | Plant | aqueous extract | leaves | acetol,D-sphignosin, 5-aminoimidazole-1-carboxyamie, caffeic acid,chlorogenic acid, neohesperedin,O-acetylsalicylic acid, quinic acid,3,4-dihydroxybenzoic acid, andDL-hydroxyphenylglycol | Korea | 2012 | [181] | |
Enicostemma littorale | Plant | chloroform, methanol and acetone by soxhlet apparatus | leaves, stem and root | not specified | India | 2012 | [182] | |
Plant | aqueous and ethanolic extracts | flower extract | cyanidin, quercetin, hentriacontane, calcium oxalate, thiamine, riboflavin, niacin and ascorbic acids | India | 2012 | [183] | ||
Capsicum annuum and | Plant | aqueous and methanolic extracts | fruit | alkaloids, flavonoids, polyphenols, and sterols | Ivory Coast | 2012 | [184] | |
Coriandrum sativam (L.) | Plant | essential oil | fruit dry | Bicycle(4.1.0),heptanes,3,7,7-trimethyl-(1a,6a,3a), propanoic acid,2-methyl-3,7-dimethyl octadiennyl ester,(E)-, 2- undecenal, 2-Napthalenemethanol, decahydro-a,a,4a-trimethyl-8-methylene- [2R-(2a,4aa,8aa)] | India | 2012 | [185] | |
Berberis baluchistanica, Seriphidium quettense, Iphionaaucheri, Ferula costata | Plant | crude methanol extracts | roots, aerial parts | not specified | Pakistan | 2012 | [186] | |
Plant | aqueous and ethanolic extracts | aerial parts | not specified | Mexico | 2012 | [187] | ||
Ocimum gratissimum and Gongronema latifolium | Plant | aqueous and ethanolic extracts | leaves and stem | not specified | Nigeria | 2012 | [188] | |
Curry: Capsicum annuum, Citrus hystrix, Cuminum cyminum L., Allium ascalonicum L., Allium sativum, Cybopogon citratus, Alpinia galangal, ando coconut milk | Plant | Kaeng Kathi (UHT coconut milk | fruit, peel, seed, bulb, stem, rhizome | not specified | Indonesia | 2012 | [189] | |
Plant | ethanolic extract | leaves | not specified | Indonesia | 2012 | [190] | ||
Ocimum gratissimum | Plant | ethanol extracts | leaves | alkaloids, cardiac glycosides, saponins, tannins and steroids | Nigeria | 2011 | [191] | |
Plant | 95% ethanol | fruit | anythocyanins and syringic acid | Thailand | 2011 | [192] | ||
Quercus | Plant | ethanol by soxhlet apparatus | acorn | not specified | Iran | 2011 | [193] | |
Sonchus spp. (6 sp) | Plant | methanolic extract | aerial parts | phenols and flavonoids | China | 2011 | [194] | |
York cabbage, Brussels sprouts, broccoli and white cabbage | Plant | methanolic extract | whole plant | Hydroxybenzoic acid, hydroxycinnamic acid, flavone, polymethoxylated flavone, glycosylated flavonoid and anthocyanin | Ireland | 2011 | [195] | |
Achyrocline satureioides | Plant | ethanolic extract | aerial parts | 23-methyl-6-Odesmethylauricepyrone | Argentina | 2011 | [196] | |
Plant | methanolic extract | fruit | not specified | Bangladesh | 2011 | [197] | ||
Plant | methanolic extract | leaves and roots | not specified | India | 2011 | [198] | ||
Punica granatum | Plant | ethanolic extract | peel | not specified | Korea | 2011 | [199] | |
Punica granatum L.. Eugenia jambolana Lam., | Plant | hydromethanolic extracts | leaves, fruit, package content, aerial and flowered aerial portions. | not specified | Brazil | 2011 | [200] | |
Plant | methanolic and ethanolic extracts | seed | saponins, flavonoids, Tannins, alkaloids, and steroids | Nigeria | 2011 | [201] | ||
Plant | methanolic and ethanolic extracts | leaves | Anthraquinone, Alkaloids, Saponins, Balsams, Flavonoids and Tannins | Nigeria | 2011 | [202] | ||
Gynostemma pentaphyllum | Plant | ethanolic extract | leave, stem | not specified | Thailand | 2011 | [203] | |
Terminalia stenostachya y Terminaliaspinosa | Plant | dichloromethanic, methanolic, acetone and ethanolic extracts | stem barks and roots | not specified | Tanzania | 2011 | [204] | |
Hofmeisteria schaffneri | Plant | infusion and essential oil | aerial parts | hofmeisterin III, thymyl isovalerate and 8,9-epoxy-10-acetoxythymyl angelate | Mexico | 2011 | [205] | |
Ficus polita Vahl. | Plant | methanolic extract | roots | euphol-3- O -cinamato C 39 H 56 O 2, lupeol C 30 H 50 O, taraxar-14-eno C30 H 50 O 1 | Cameroon | 2011 | [206] | |
Plant | aqueous and methanolic extracts | vegetables, seeds | not specified | Pakistan | 2011 | [207] | ||
75 plants (Healianthus annum Linn.) | Plant | ethanolic extracts | leaves | not specified | India | 2010 | [208] | |
Plant | aqueous and ethanolic extracts | leaves | flavonoids, alkaloids, | India | 2010 | [209] | ||
Black pepper (Piper nigrum Linn.) | Plant | acetone extract; dichloromethanic extract; | fruit | piperine | India | 2010 | [210] | |
Abrus precatorius L. | Plant | methanolic and petroleum ether extract | leaves, seeds and roots | Methanolic and petroleum ether extract | India | 2010 | [211] | |
Psidium guajava | Plant | methanolic extract | leaves | flavonoids: morin-3-Olyxoside, morin-3-O-arabinoside, quercetin-3-Oarabinoside and quercetin. Anthocyans, alkaloids, tannins, and terpenoids. | Thailand | 2010 | [212] | |
Origanum vulgare L. | Plant | essential oils | aerial parts | not specified | Turkey | 2010 | [213] | |
Plant | methanolic extract | leaves | not specified | India | 2010 | [214] | ||
Plant | chloroform and methanol | whole plant | not specified | India | 2010 | [215] | ||
(Adiantaceae), Adiantum incisum forsk. (Adiantaceae), Adiantum lunulatum Burm. F. (Adiantaceae), Actiniopteris radiata (Swartz.), Enlace (Actiniopteridaceae), Araiostegia pseudocystopteris Copel. (Davalliaceae), Athyrium pectinatum (Wall ex Mett.) T. Moore (Athyriaceae), Chelienthes albomarginata Clarke (Sinopteridaceae), | Plant | aqueous and methanolic extracts | leaves | not specified | India | 2010 | [216] | |
Ecklonia cava | Plant (algae) | EtOH followed by n-hexane, CH2Cl2, EtOAc, n-BuOH (10 g) and aqueous | not specified (probably full algae) | Eckol | Korea | 2010 | [217] | |
Thymus vulgaris L., Ocimum basilicum L., Coriandrum sativum L., Rosmarinus officinalis L., Salvia officinalis L., Foeniculum vulgare L., Mentha spicata L., Carum carvi L. | Plant | essential oil | not specified | not specified | Romania | 2010 | [218] | |
Pikutbenjakul = | Plant | ethanolic extract | not specified | not specified | Thailand | 2010 | [219] | |
Quercus infectoria, | Plant | DMSO | galls, roots, rhizomes, | not specified | Thailand | 2010 | [220] | |
Eugenol | Plant | essential oil of clove | flower extract | 177 peaks and HHDP-gallagyl-hexoside | Indonesia | 2010 | [221] | |
Plant | methanolic extract | not especified | polyphenols, alkaloids and steroids | Cameroon | 2010 | [222] |
Summary of frequently reported natural products from plant origin against
Parental organism | Extraction method | Segment used | Bioactive compound(s) | Location | Year | Ref | ||
---|---|---|---|---|---|---|---|---|
Goat milk kefir (Lactococcus cremoris, Streptococcus cremoris | Bacteria and Yeast | no extraction | microbial cells | lactic acid, ethanol and CO2, diacetyl acetaldehyde, ethyl and | Indonesia | 2019 | [223] | |
Epicoccum nigrum, | Fungus and plant | ethyl acetate extract | leaves | not specified | Cameroon | 2017 | [224] | |
Origanum vulgare, Lactococcus lactis (Nisin), EDTA | Plant and Bacteria | essential oil | seeds | carvacrol, p-cymene and y-terpinene | Brazil | 2016 | [225] | |
Allium sativum, Nigella sativa, | Plant and Animal | aqueous extracts | bulb, seed, leaves and fruit | not specified | Pakistan | 2014 | [226] | |
Apis mellipodae honey and Allium sativum | Animal and plant | macerated and aqueous dilution | honey/bulb | Honey: high, osmolarity, hydrogen peroxidase, acidity and Allium sativum: allicin | Ethiopia | 2013 | [227] |
Summary of reported natural products of combined origins against
All these works were developed on all continents, being Asia the most active, followed by Africa, America, Europe and Oceania (Figure 1A and B). It is noteworthy that much of the research was developed in equatorial locations where biodiversity is abundant. Country-wise, there is a remarkable number of publications from India and Indonesia, where incidence of
(A) Distribution map of publishing frequencies. (B) Continental frequency. (C) Publications per year.
The spectrum of biological activities evaluated are as diverse as the application to which they are oriented, from the study of antimutagenic, antioxidant, anticancer, anthelmintic, antiviral, antifungal activities to its antibacterial potential, being its activity against
The analysis of the last decade research render studies exploring the antibacterial activity against
Nonetheless, we believe the description of methodological conditions could further standardized with the inclusion of a fixed set of data. According to our observation, the list of items enlisted in Table 6 could be a minimal checklist when performing NP research.
Animal species | Vegetable species | Microorganisms | Solvents | Bioactive compound |
---|---|---|---|---|
Identification of genus and, if possible, species | Geographical site | Identification of genus, and species | Explanation for its selection | Isolation technique |
Harvesting data | Reference strain identification | No-reactivity assessment | Structure determination method (MS–GC, for instance) | |
Ethnobiological identification | Identification of origin:
| No-interference assessment | ||
Identification by PCR | No-toxicity assessment |
Checklist proposed for NPs research.
Salmonellosis, caused by
Most of the works displayed in here are initial screening in vitro studies, maybe due to the scarce number of sources for funding in vivo applications. In perspective, NPs studies for clinical applications is a potential goal in order to control this disease.
Authors acknowledge Hospital Juarez of Mexico for giving the facilities for writing this chapter. This work was developed with no funding.
Authors declare no conflict of interests.
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His studies in robotics lead him not only to a PhD degree but also inspired him to co-found and build the International Journal of Advanced Robotic Systems - world's first Open Access journal in the field of robotics.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"441",title:"Ph.D.",name:"Jaekyu",middleName:null,surname:"Park",slug:"jaekyu-park",fullName:"Jaekyu Park",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/441/images/1881_n.jpg",biography:null,institutionString:null,institution:{name:"LG Corporation (South Korea)",country:{name:"Korea, South"}}},{id:"465",title:"Dr",name:"Christian",middleName:null,surname:"Martens",slug:"christian-martens",fullName:"Christian Martens",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"479",title:"Dr.",name:"Valentina",middleName:null,surname:"Colla",slug:"valentina-colla",fullName:"Valentina Colla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/479/images/358_n.jpg",biography:null,institutionString:null,institution:{name:"Sant'Anna School of Advanced Studies",country:{name:"Italy"}}},{id:"494",title:"PhD",name:"Loris",middleName:null,surname:"Nanni",slug:"loris-nanni",fullName:"Loris Nanni",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/494/images/system/494.jpg",biography:"Loris Nanni received his Master Degree cum laude on June-2002 from the University of Bologna, and the April 26th 2006 he received his Ph.D. in Computer Engineering at DEIS, University of Bologna. On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. His research interests include pattern recognition, bioinformatics, and biometric systems (fingerprint classification and recognition, signature verification, face recognition).",institutionString:null,institution:null},{id:"496",title:"Dr.",name:"Carlos",middleName:null,surname:"Leon",slug:"carlos-leon",fullName:"Carlos Leon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Seville",country:{name:"Spain"}}},{id:"512",title:"Dr.",name:"Dayang",middleName:null,surname:"Jawawi",slug:"dayang-jawawi",fullName:"Dayang Jawawi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Technology Malaysia",country:{name:"Malaysia"}}},{id:"528",title:"Dr.",name:"Kresimir",middleName:null,surname:"Delac",slug:"kresimir-delac",fullName:"Kresimir Delac",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/528/images/system/528.jpg",biography:"K. Delac received his B.Sc.E.E. degree in 2003 and is currentlypursuing a Ph.D. degree at the University of Zagreb, Faculty of Electrical Engineering andComputing. His current research interests are digital image analysis, pattern recognition andbiometrics.",institutionString:null,institution:{name:"University of Zagreb",country:{name:"Croatia"}}},{id:"557",title:"Dr.",name:"Andon",middleName:"Venelinov",surname:"Topalov",slug:"andon-topalov",fullName:"Andon Topalov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/557/images/1927_n.jpg",biography:"Dr. Andon V. Topalov received the MSc degree in Control Engineering from the Faculty of Information Systems, Technologies, and Automation at Moscow State University of Civil Engineering (MGGU) in 1979. He then received his PhD degree in Control Engineering from the Department of Automation and Remote Control at Moscow State Mining University (MGSU), Moscow, in 1984. From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. His current research interests are in the fields of intelligent control and robotics.",institutionString:null,institution:{name:"Technical University of Sofia",country:{name:"Bulgaria"}}},{id:"585",title:"Prof.",name:"Munir",middleName:null,surname:"Merdan",slug:"munir-merdan",fullName:"Munir Merdan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/585/images/system/585.jpg",biography:"Munir Merdan received the M.Sc. degree in mechanical engineering from the Technical University of Sarajevo, Bosnia and Herzegovina, in 2001, and the Ph.D. degree in electrical engineering from the Vienna University of Technology, Vienna, Austria, in 2009.Since 2005, he has been at the Automation and Control Institute, Vienna University of Technology, where he is currently a Senior Researcher. His research interests include the application of agent technology for achieving agile control in the manufacturing environment.",institutionString:null,institution:null},{id:"605",title:"Prof",name:"Dil",middleName:null,surname:"Hussain",slug:"dil-hussain",fullName:"Dil Hussain",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/605/images/system/605.jpg",biography:"Dr. Dil Muhammad Akbar Hussain is a professor of Electronics Engineering & Computer Science at the Department of Energy Technology, Aalborg University Denmark. Professor Akbar has a Master degree in Digital Electronics from Govt. College University, Lahore Pakistan and a P-hD degree in Control Engineering from the School of Engineering and Applied Sciences, University of Sussex United Kingdom. Aalborg University has Two Satellite Campuses, one in Copenhagen (Aalborg University Copenhagen) and the other in Esbjerg (Aalborg University Esbjerg).\n· He is a member of prestigious IEEE (Institute of Electrical and Electronics Engineers), and IAENG (International Association of Engineers) organizations. \n· He is the chief Editor of the Journal of Software Engineering.\n· He is the member of the Editorial Board of International Journal of Computer Science and Software Technology (IJCSST) and International Journal of Computer Engineering and Information Technology. \n· He is also the Editor of Communication in Computer and Information Science CCIS-20 by Springer.\n· Reviewer For Many Conferences\nHe is the lead person in making collaboration agreements between Aalborg University and many universities of Pakistan, for which the MOU’s (Memorandum of Understanding) have been signed.\nProfessor Akbar is working in Academia since 1990, he started his career as a Lab demonstrator/TA at the University of Sussex. After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. 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Utkin",authors:[{id:"16132",title:"Dr.",name:"Andrei",middleName:"B.",surname:"Utkin",slug:"andrei-utkin",fullName:"Andrei Utkin"}]},{id:"73811",doi:"10.5772/intechopen.94103",title:"Introduction to Quantum Computing",slug:"introduction-to-quantum-computing",totalDownloads:1206,totalCrossrefCites:3,totalDimensionsCites:4,abstract:"Quantum computing is a modern way of computing that is based on the science of quantum mechanics and its unbelievable phenomena. It is a beautiful combination of physics, mathematics, computer science and information theory. It provides high computational power, less energy consumption and exponential speed over classical computers by controlling the behavior of small physical objects i.e. microscopic particles like atoms, electrons, photons, etc. Here, we present an introduction to the fundamental concepts and some ideas of quantum computing. This paper starts with the origin of traditional computing and discusses all the improvements and transformations that have been done due to their limitations until now. Then it moves on to the basic working of quantum computing and the quantum properties it follows like superposition, entanglement and interference. To understand the full potentials and challenges of a practical quantum computer that can be launched commercially, the paper covers the architecture, hardware, software, design, types and algorithms that are specifically required by the quantum computers. It uncovers the capability of quantum computers that can impact our lives in various viewpoints like cyber security, traffic optimization, medicines, artificial intelligence and many more. At last, we concluded all the importance, advantages and disadvantages of quantum computers. Small-scale quantum computers are being developed recently. This development is heading towards a great future due to their high potential capabilities and advancements in ongoing research. Before focusing on the significances of a general-purpose quantum computer and exploring the power of the new arising technology, it is better to review the origin, potentials, and limitations of the existing traditional computing. This information helps us in understanding the possible challenges in developing exotic and competitive technology. It will also give us an insight into the ongoing progress in this field.",book:{id:"10209",slug:"quantum-computing-and-communications",title:"Quantum Computing and Communications",fullTitle:"Quantum Computing and Communications"},signatures:"Surya Teja Marella and Hemanth Sai Kumar Parisa",authors:[{id:"297632",title:"Mr.",name:"Surya Teja",middleName:null,surname:"Marella",slug:"surya-teja-marella",fullName:"Surya Teja Marella"},{id:"336267",title:"Mr.",name:"Hemanth Sai Kumar",middleName:null,surname:"Parisa",slug:"hemanth-sai-kumar-parisa",fullName:"Hemanth Sai Kumar Parisa"}]}],mostDownloadedChaptersLast30Days:[{id:"73811",title:"Introduction to Quantum Computing",slug:"introduction-to-quantum-computing",totalDownloads:1206,totalCrossrefCites:3,totalDimensionsCites:4,abstract:"Quantum computing is a modern way of computing that is based on the science of quantum mechanics and its unbelievable phenomena. It is a beautiful combination of physics, mathematics, computer science and information theory. It provides high computational power, less energy consumption and exponential speed over classical computers by controlling the behavior of small physical objects i.e. microscopic particles like atoms, electrons, photons, etc. Here, we present an introduction to the fundamental concepts and some ideas of quantum computing. This paper starts with the origin of traditional computing and discusses all the improvements and transformations that have been done due to their limitations until now. Then it moves on to the basic working of quantum computing and the quantum properties it follows like superposition, entanglement and interference. To understand the full potentials and challenges of a practical quantum computer that can be launched commercially, the paper covers the architecture, hardware, software, design, types and algorithms that are specifically required by the quantum computers. It uncovers the capability of quantum computers that can impact our lives in various viewpoints like cyber security, traffic optimization, medicines, artificial intelligence and many more. At last, we concluded all the importance, advantages and disadvantages of quantum computers. Small-scale quantum computers are being developed recently. This development is heading towards a great future due to their high potential capabilities and advancements in ongoing research. Before focusing on the significances of a general-purpose quantum computer and exploring the power of the new arising technology, it is better to review the origin, potentials, and limitations of the existing traditional computing. This information helps us in understanding the possible challenges in developing exotic and competitive technology. It will also give us an insight into the ongoing progress in this field.",book:{id:"10209",slug:"quantum-computing-and-communications",title:"Quantum Computing and Communications",fullTitle:"Quantum Computing and Communications"},signatures:"Surya Teja Marella and Hemanth Sai Kumar Parisa",authors:[{id:"297632",title:"Mr.",name:"Surya Teja",middleName:null,surname:"Marella",slug:"surya-teja-marella",fullName:"Surya Teja Marella"},{id:"336267",title:"Mr.",name:"Hemanth Sai Kumar",middleName:null,surname:"Parisa",slug:"hemanth-sai-kumar-parisa",fullName:"Hemanth Sai Kumar Parisa"}]},{id:"71370",title:"Complex Space Nature of the Quantum World: Return Causality to Quantum Mechanics",slug:"complex-space-nature-of-the-quantum-world-return-causality-to-quantum-mechanics",totalDownloads:1001,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"As one chapter, we about to begin a journey with exploring the limitation of the causality that rules the whole universe. Quantum mechanics is established on the basis of the phenomenology and the lack of ontology builds the wall which blocks the causality. It is very difficult to reconcile the probability and the causality in such a platform. A higher dimension consideration may leverage this dilemma by expanding the vision. Information may seem to be discontinuous or even so weird if only be viewed from a part of the degree of freedoms. Based on this premise, we reexamined the microscopic world within a complex space. Significantly, some knowledge beyond the empirical findings is revealed and paves the way for a more detailed exploration of the quantum world. The random quantum motion is essential for atomic particle and exhibits a wave-related property with a bulk of trajectories. It seems we can break down the wall which forbids the causality entering the quantum kingdom and connect quantum mechanics with classical mechanics. The causality returns to the quantum world without any assumption in terms of the quantum random motion under the optimal guidance law in complex space. Thereby hangs a tale, we briefly introduce this new formulation from the fundamental theoretical description to the practical technology applications.",book:{id:"10076",slug:"quantum-mechanics",title:"Quantum Mechanics",fullTitle:"Quantum Mechanics"},signatures:"Ciann-Dong Yang and Shiang-Yi Han",authors:[{id:"158670",title:"Prof.",name:"Ciann-Dong",middleName:null,surname:"Yang",slug:"ciann-dong-yang",fullName:"Ciann-Dong Yang"},{id:"315900",title:"Dr.",name:"Shiang-Yi",middleName:null,surname:"Han",slug:"shiang-yi-han",fullName:"Shiang-Yi Han"}]},{id:"72922",title:"Analysis of Quantum Confinement and Carrier Transport of Nano-Transistor in Quantum Mechanics",slug:"analysis-of-quantum-confinement-and-carrier-transport-of-nano-transistor-in-quantum-mechanics",totalDownloads:622,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"Quantum mechanics is the branch of physics that consists of laws explaining the physical properties of the nature of nano-particles and their characteristics on an atomic scale. The study of nano-particles significantly challenges our current perception of the universe and the fabric of reality itself. Quantum particles have both wave-like and particle-like characteristics. The fundamental equation that predicts the physical behaviour of a quantum system is the Schrödinger equation and the Poisson equation using Monte Carlo simulations. This gives rise to the wavefunction, electron and hole densities, energy levels and band structure of the system which contains all the measurable information about the particle such as time and position, where position is represented using probabilities. This is because particles do not have one definite position during the time before measurement. In fact, they exist as a fuzzy distribution of all possible states where the likelihood of finding the particle in some states is more probable than others. This is known as being in a superposition of all states. When the quantum system is observed, however, its wavefunction collapses so it consequently falls into one specific position. Moreover, in this chapter we present the simulation results of conduction band profile, electron density (classical and quantum mechanical), eigenstate and eigenfunctions for Si, SOI and III-V MOSFET structures at bias voltage 1.0 V using 1D Poisson-Schrödinger solver.",book:{id:"10076",slug:"quantum-mechanics",title:"Quantum Mechanics",fullTitle:"Quantum Mechanics"},signatures:"Aynul Islam and Anika Tasnim Aynul",authors:[{id:"316001",title:"Dr.",name:"Islam",middleName:null,surname:"Aynul",slug:"islam-aynul",fullName:"Islam Aynul"},{id:"325161",title:"BSc.",name:"Anika Tasnim",middleName:null,surname:"Aynul",slug:"anika-tasnim-aynul",fullName:"Anika Tasnim Aynul"}]},{id:"71547",title:"Dipolar Interactions: Hyperfine Structure Interaction and Fine Structure Interactions",slug:"dipolar-interactions-hyperfine-structure-interaction-and-fine-structure-interactions",totalDownloads:636,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"The interaction between the nuclear spin and the electron spin creates a hyperfine structure. Hyperfine structure interaction occurs in paramagnetic structures with unpaired electrons. Therefore, hyperfine structure interaction is the most important of the fundamental parameters investigated by electron paramagnetic resonance (EPR) spectroscopy. For EPR spectroscopy the two effective Hamiltonian terms are the hyperfine structure interaction and the electronic Zeeman interaction. The hyperfine structure interaction has two types as isotropic and anisotropic hyperfine structure interactions. The zero-field splitting term (electronic quadrupole fine structure), the nuclear Zeeman term, and the nuclear quadrupole interaction term are among the Hamiltonian terms used in EPR. However, their effects are not as much as the term of the hyperfine structure interaction. The zero-field splitting term and the nuclear quadrupole interaction term are the fine structure terms. The interaction of two electron spins create a zero-field splitting, the interaction between the two nucleus spins form the nuclear quadrupole interaction. Hyperfine structure interaction, zero-field interaction, and nuclear quadrupole interaction are subclasses of dipolar interaction. Interaction tensors are available for all three interactions.",book:{id:"10076",slug:"quantum-mechanics",title:"Quantum Mechanics",fullTitle:"Quantum Mechanics"},signatures:"Betül Çalişkan and Ali Cengiz Çalişkan",authors:[{id:"199110",title:"Dr.",name:"Betül",middleName:null,surname:"Çalişkan",slug:"betul-caliskan",fullName:"Betül Çalişkan"},{id:"208732",title:"Dr.",name:"Ali Cengiz",middleName:null,surname:"Çalişkan",slug:"ali-cengiz-caliskan",fullName:"Ali Cengiz Çalişkan"}]},{id:"73016",title:"Exactly Solvable Problems in Quantum Mechanics",slug:"exactly-solvable-problems-in-quantum-mechanics",totalDownloads:708,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"Some of the problems in quantum mechanics can be exactly solved without any approximation. Some of the exactly solvable problems are discussed in this chapter. Broadly there are two main approaches to solve such problems. They are (i) based on the solution of the Schrödinger equation and (ii) based on operators. 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She is now a lecturer at the University of Witwatersrand, South Africa, and a principal researcher at the Health Economics and Epidemiology Research Office (HE2RO), South Africa. Dr. Moolla holds a Ph.D. in Psychology with her research being focused on mental health and resilience. In her professional work capacity, her research has further expanded into the fields of early childhood development, mental health, the HIV and TB care cascades, as well as COVID. She is also a UNESCO-trained International Bioethics Facilitator.",institutionString:"University of the Witwatersrand",institution:{name:"University of the Witwatersrand",country:{name:"South Africa"}}},{id:"342152",title:"Dr.",name:"Santo",middleName:null,surname:"Grace Umesh",slug:"santo-grace-umesh",fullName:"Santo Grace Umesh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/342152/images/16311_n.jpg",biography:null,institutionString:null,institution:{name:"SRM Dental College",country:{name:"India"}}},{id:"333647",title:"Dr.",name:"Shreya",middleName:null,surname:"Kishore",slug:"shreya-kishore",fullName:"Shreya Kishore",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333647/images/14701_n.jpg",biography:"Dr. Shreya Kishore completed her Bachelor in Dental Surgery in Chettinad Dental College and Research Institute, Chennai, and her Master of Dental Surgery (Orthodontics) in Saveetha Dental College, Chennai. She is also Invisalign certified. She’s working as a Senior Lecturer in the Department of Orthodontics, SRM Dental College since November 2019. She is actively involved in teaching orthodontics to the undergraduates and the postgraduates. Her clinical research topics include new orthodontic brackets, fixed appliances and TADs. She’s published 4 articles in well renowned indexed journals and has a published patency of her own. Her private practice is currently limited to orthodontics and works as a consultant in various clinics.",institutionString:null,institution:{name:"SRM Dental College",country:{name:"India"}}},{id:"323731",title:"Prof.",name:"Deepak M.",middleName:"Macchindra",surname:"Vikhe",slug:"deepak-m.-vikhe",fullName:"Deepak M. Vikhe",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/323731/images/13613_n.jpg",biography:"Dr Deepak M.Vikhe .\n\n\t\n\tDr Deepak M.Vikhe , completed his Masters & PhD in Prosthodontics from Rural Dental College, Loni securing third rank in the Pravara Institute of Medical Sciences Deemed University. He was awarded Dr.G.C.DAS Memorial Award for Research on Implants at 39th IPS conference Dubai (U A E).He has two patents under his name. He has received Dr.Saraswati medal award for best research for implant study in 2017.He has received Fully funded scholarship to Spain ,university of Santiago de Compostela. He has completed fellowship in Implantlogy from Noble Biocare. \nHe has attended various conferences and CDE programmes and has national publications to his credit. His field of interest is in Implant supported prosthesis. Presently he is working as a associate professor in the Dept of Prosthodontics, Rural Dental College, Loni and maintains a successful private practice specialising in Implantology at Rahata.\n\nEmail: drdeepak_mvikhe@yahoo.com..................",institutionString:null,institution:{name:"Pravara Institute of Medical Sciences",country:{name:"India"}}},{id:"204110",title:"Dr.",name:"Ahmed A.",middleName:null,surname:"Madfa",slug:"ahmed-a.-madfa",fullName:"Ahmed A. Madfa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204110/images/system/204110.jpg",biography:"Dr. Madfa is currently Associate Professor of Endodontics at Thamar University and a visiting lecturer at Sana'a University and University of Sciences and Technology. He has more than 6 years of experience in teaching. His research interests include root canal morphology, functionally graded concept, dental biomaterials, epidemiology and dental education, biomimetic restoration, finite element analysis and endodontic regeneration. Dr. Madfa has numerous international publications, full articles, two patents, a book and a book chapter. Furthermore, he won 14 international scientific awards. Furthermore, he is involved in many academic activities ranging from editorial board member, reviewer for many international journals and postgraduate students' supervisor. Besides, I deliver many courses and training workshops at various scientific events. Dr. Madfa also regularly attends international conferences and holds administrative positions (Deputy Dean of the Faculty for Students’ & Academic Affairs and Deputy Head of Research Unit).",institutionString:"Thamar University",institution:null},{id:"210472",title:"Dr.",name:"Nermin",middleName:"Mohammed Ahmed",surname:"Yussif",slug:"nermin-yussif",fullName:"Nermin Yussif",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/210472/images/system/210472.jpg",biography:"Dr. Nermin Mohammed Ahmed Yussif is working at the Faculty of dentistry, University for October university for modern sciences and arts (MSA). Her areas of expertise include: periodontology, dental laserology, oral implantology, periodontal plastic surgeries, oral mesotherapy, nutrition, dental pharmacology. She is an editor and reviewer in numerous international journals.",institutionString:"MSA University",institution:null},{id:"204606",title:"Dr.",name:"Serdar",middleName:null,surname:"Gözler",slug:"serdar-gozler",fullName:"Serdar Gözler",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204606/images/system/204606.jpeg",biography:"Dr. Serdar Gözler has completed his undergraduate studies at the Marmara University Faculty of Dentistry in 1978, followed by an assistantship in the Prosthesis Department of Dicle University Faculty of Dentistry. Starting his PhD work on non-resilient overdentures with Assoc. Prof. Hüsnü Yavuzyılmaz, he continued his studies with Prof. Dr. Gürbüz Öztürk of Istanbul University Faculty of Dentistry Department of Prosthodontics, this time on Gnatology. He attended training programs on occlusion, neurology, neurophysiology, EMG, radiology and biostatistics. In 1982, he presented his PhD thesis \\Gerber and Lauritzen Occlusion Analysis Techniques: Diagnosis Values,\\ at Istanbul University School of Dentistry, Department of Prosthodontics. As he was also working with Prof. Senih Çalıkkocaoğlu on The Physiology of Chewing at the same time, Gözler has written a chapter in Çalıkkocaoğlu\\'s book \\Complete Prostheses\\ entitled \\The Place of Neuromuscular Mechanism in Prosthetic Dentistry.\\ The book was published five times since by the Istanbul University Publications. Having presented in various conferences about occlusion analysis until 1998, Dr. Gözler has also decided to use the T-Scan II occlusion analysis method. Having been personally trained by Dr. Robert Kerstein on this method, Dr. Gözler has been lecturing on the T-Scan Occlusion Analysis Method in conferences both in Turkey and abroad. Dr. Gözler has various articles and presentations on Digital Occlusion Analysis methods. He is now Head of the TMD Clinic at Prosthodontic Department of Faculty of Dentistry , Istanbul Aydın University , Turkey.",institutionString:"Istanbul Aydin University",institution:{name:"Istanbul Aydın University",country:{name:"Turkey"}}},{id:"240870",title:"Ph.D.",name:"Alaa Eddin Omar",middleName:null,surname:"Al Ostwani",slug:"alaa-eddin-omar-al-ostwani",fullName:"Alaa Eddin Omar Al Ostwani",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/240870/images/system/240870.jpeg",biography:"Dr. Al Ostwani Alaa Eddin Omar received his Master in dentistry from Damascus University in 2010, and his Ph.D. in Pediatric Dentistry from Damascus University in 2014. Dr. Al Ostwani is an assistant professor and faculty member at IUST University since 2014. \nDuring his academic experience, he has received several awards including the scientific research award from the Union of Arab Universities, the Syrian gold medal and the international gold medal for invention and creativity. Dr. Al Ostwani is a Member of the International Association of Dental Traumatology and the Syrian Society for Research and Preventive Dentistry since 2017. He is also a Member of the Reviewer Board of International Journal of Dental Medicine (IJDM), and the Indian Journal of Conservative and Endodontics since 2016.",institutionString:"International University for Science and Technology.",institution:{name:"Islamic University of Science and Technology",country:{name:"India"}}},{id:"42847",title:"Dr.",name:"Belma",middleName:null,surname:"Işik Aslan",slug:"belma-isik-aslan",fullName:"Belma Işik Aslan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/42847/images/system/42847.jpg",biography:"Dr. Belma IşIk Aslan was born in 1976 in Ankara-TURKEY. After graduating from TED Ankara College in 1994, she attended to Gazi University, Faculty of Dentistry in Ankara. She completed her PhD in orthodontic education at Gazi University between 1999-2005. Dr. Işık Aslan stayed at the Providence Hospital Craniofacial Institude and Reconstructive Surgery in Michigan, USA for three months as an observer. She worked as a specialist doctor at Gazi University, Dentistry Faculty, Department of Orthodontics between 2005-2014. She was appointed as associate professor in January, 2014 and as professor in 2021. Dr. Işık Aslan still works as an instructor at the same faculty. She has published a total of 35 articles, 10 book chapters, 39 conference proceedings both internationally and nationally. Also she was the academic editor of the international book 'Current Advances in Orthodontics'. She is a member of the Turkish Orthodontic Society and Turkish Cleft Lip and Palate Society. She is married and has 2 children. Her knowledge of English is at an advanced level.",institutionString:"Gazi University Dentistry Faculty Department of Orthodontics",institution:null},{id:"178412",title:"Associate Prof.",name:"Guhan",middleName:null,surname:"Dergin",slug:"guhan-dergin",fullName:"Guhan Dergin",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178412/images/6954_n.jpg",biography:"Assoc. Prof. Dr. Gühan Dergin was born in 1973 in Izmit. He graduated from Marmara University Faculty of Dentistry in 1999. He completed his specialty of OMFS surgery in Marmara University Faculty of Dentistry and obtained his PhD degree in 2006. In 2005, he was invited as a visiting doctor in the Oral and Maxillofacial Surgery Department of the University of North Carolina, USA, where he went on a scholarship. Dr. Dergin still continues his academic career as an associate professor in Marmara University Faculty of Dentistry. He has many articles in international and national scientific journals and chapters in books.",institutionString:null,institution:{name:"Marmara University",country:{name:"Turkey"}}},{id:"178414",title:"Prof.",name:"Yusuf",middleName:null,surname:"Emes",slug:"yusuf-emes",fullName:"Yusuf Emes",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178414/images/6953_n.jpg",biography:"Born in Istanbul in 1974, Dr. Emes graduated from Istanbul University Faculty of Dentistry in 1997 and completed his PhD degree in Istanbul University faculty of Dentistry Department of Oral and Maxillofacial Surgery in 2005. He has papers published in international and national scientific journals, including research articles on implantology, oroantral fistulas, odontogenic cysts, and temporomandibular disorders. Dr. Emes is currently working as a full-time academic staff in Istanbul University faculty of Dentistry Department of Oral and Maxillofacial Surgery.",institutionString:null,institution:{name:"Istanbul University",country:{name:"Turkey"}}},{id:"192229",title:"Ph.D.",name:"Ana Luiza",middleName:null,surname:"De Carvalho Felippini",slug:"ana-luiza-de-carvalho-felippini",fullName:"Ana Luiza De Carvalho Felippini",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192229/images/system/192229.jpg",biography:null,institutionString:"University of São Paulo",institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"256851",title:"Prof.",name:"Ayşe",middleName:null,surname:"Gülşen",slug:"ayse-gulsen",fullName:"Ayşe Gülşen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/256851/images/9696_n.jpg",biography:"Dr. Ayşe Gülşen graduated in 1990 from Faculty of Dentistry, University of Ankara and did a postgraduate program at University of Gazi. \nShe worked as an observer and research assistant in Craniofacial Surgery Departments in New York, Providence Hospital in Michigan and Chang Gung Memorial Hospital in Taiwan. \nShe works as Craniofacial Orthodontist in Department of Aesthetic, Plastic and Reconstructive Surgery, Faculty of Medicine, University of Gazi, Ankara Turkey since 2004.",institutionString:"Univeristy of Gazi",institution:null},{id:"255366",title:"Prof.",name:"Tosun",middleName:null,surname:"Tosun",slug:"tosun-tosun",fullName:"Tosun Tosun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255366/images/7347_n.jpg",biography:"Graduated at the Faculty of Dentistry, University of Istanbul, Turkey in 1989;\nVisitor Assistant at the University of Padua, Italy and Branemark Osseointegration Center of Treviso, Italy between 1993-94;\nPhD thesis on oral implantology in University of Istanbul and was awarded the academic title “Dr.med.dent.”, 1997;\nHe was awarded the academic title “Doç.Dr.” (Associated Professor) in 2003;\nProficiency in Botulinum Toxin Applications, Reading-UK in 2009;\nMastership, RWTH Certificate in Laser Therapy in Dentistry, AALZ-Aachen University, Germany 2009-11;\nMaster of Science (MSc) in Laser Dentistry, University of Genoa, Italy 2013-14.\n\nDr.Tosun worked as Research Assistant in the Department of Oral Implantology, Faculty of Dentistry, University of Istanbul between 1990-2002. \nHe worked part-time as Consultant surgeon in Harvard Medical International Hospitals and John Hopkins Medicine, Istanbul between years 2007-09.\u2028He was contract Professor in the Department of Surgical and Diagnostic Sciences (DI.S.C.), Medical School, University of Genova, Italy between years 2011-16. \nSince 2015 he is visiting Professor at Medical School, University of Plovdiv, Bulgaria. \nCurrently he is Associated Prof.Dr. at the Dental School, Oral Surgery Dept., Istanbul Aydin University and since 2003 he works in his own private clinic in Istanbul, Turkey.\u2028\nDr.Tosun is reviewer in journal ‘Laser in Medical Sciences’, reviewer in journal ‘Folia Medica\\', a Fellow of the International Team for Implantology, Clinical Lecturer of DGZI German Association of Oral Implantology, Expert Lecturer of Laser&Health Academy, Country Representative of World Federation for Laser Dentistry, member of European Federation of Periodontology, member of Academy of Laser Dentistry. Dr.Tosun presents papers in international and national congresses and has scientific publications in international and national journals. He speaks english, spanish, italian and french.",institutionString:null,institution:{name:"Istanbul Aydın University",country:{name:"Turkey"}}},{id:"171887",title:"Prof.",name:"Zühre",middleName:null,surname:"Akarslan",slug:"zuhre-akarslan",fullName:"Zühre Akarslan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/171887/images/system/171887.jpg",biography:"Zühre Akarslan was born in 1977 in Cyprus. She graduated from Gazi University Faculty of Dentistry, Ankara, Turkey in 2000. \r\nLater she received her Ph.D. degree from the Oral Diagnosis and Radiology Department; which was recently renamed as Oral and Dentomaxillofacial Radiology, from the same university. \r\nShe is working as a full-time Associate Professor and is a lecturer and an academic researcher. \r\nHer expertise areas are dental caries, cancer, dental fear and anxiety, gag reflex in dentistry, oral medicine, and dentomaxillofacial radiology.",institutionString:"Gazi University",institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"256417",title:"Associate Prof.",name:"Sanaz",middleName:null,surname:"Sadry",slug:"sanaz-sadry",fullName:"Sanaz Sadry",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/256417/images/8106_n.jpg",biography:null,institutionString:null,institution:null},{id:"272237",title:"Dr.",name:"Pinar",middleName:"Kiymet",surname:"Karataban",slug:"pinar-karataban",fullName:"Pinar Karataban",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/272237/images/8911_n.png",biography:"Assist.Prof.Dr.Pınar Kıymet Karataban, DDS PhD \n\nDr.Pınar Kıymet Karataban was born in Istanbul in 1975. After her graduation from Marmara University Faculty of Dentistry in 1998 she started her PhD in Paediatric Dentistry focused on children with special needs; mainly children with Cerebral Palsy. She finished her pHD thesis entitled \\'Investigation of occlusion via cast analysis and evaluation of dental caries prevalance, periodontal status and muscle dysfunctions in children with cerebral palsy” in 2008. She got her Assist. Proffessor degree in Istanbul Aydın University Paediatric Dentistry Department in 2015-2018. ın 2019 she started her new career in Bahcesehir University, Istanbul as Head of Department of Pediatric Dentistry. In 2020 she was accepted to BAU International University, Batumi as Professor of Pediatric Dentistry. She’s a lecturer in the same university meanwhile working part-time in private practice in Ege Dental Studio (https://www.egedisklinigi.com/) a multidisciplinary dental clinic in Istanbul. Her main interests are paleodontology, ancient and contemporary dentistry, oral microbiology, cerebral palsy and special care dentistry. She has national and international publications, scientific reports and is a member of IAPO (International Association for Paleodontology), IADH (International Association of Disability and Oral Health) and EAPD (European Association of Pediatric Dentistry).",institutionString:null,institution:null},{id:"202198",title:"Dr.",name:"Buket",middleName:null,surname:"Aybar",slug:"buket-aybar",fullName:"Buket Aybar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202198/images/6955_n.jpg",biography:"Buket Aybar, DDS, PhD, was born in 1971. She graduated from Istanbul University, Faculty of Dentistry, in 1992 and completed her PhD degree on Oral and Maxillofacial Surgery in Istanbul University in 1997.\nDr. Aybar is currently a full-time professor in Istanbul University, Faculty of Dentistry Department of Oral and Maxillofacial Surgery. She has teaching responsibilities in graduate and postgraduate programs. Her clinical practice includes mainly dentoalveolar surgery.\nHer topics of interest are biomaterials science and cell culture studies. 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After graduating from TED Ankara College in 1986, she attended the Hacettepe University, Faculty of Dentistry in Ankara. \nIn 1993 she attended the Gazi University, Faculty of Dentistry, Department of Orthodontics for her PhD education. After finishing the PhD education, she worked as orthodontist in Ankara Dental Hospital under the Turkish Government, Ministry of Health and in a special Orthodontic Clinic till 2011. Between 2011 and 2016, Dr. Deniz Uzuner worked as a specialist in the Department of Orthodontics, Faculty of Dentistry, Gazi University in Ankara/Turkey. In 2016, she was appointed associate professor. Dr. Deniz Uzuner has authored 23 Journal Papers, 3 Book Chapters and has had 39 oral/poster presentations. She is a member of the Turkish Orthodontic Society. 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