\r\n\tEqually important are the consequences deriving from the extraordinary nature of the present times. The COVID-19 pandemic and the restrictive measures to contain the infection (lockdown and "physical distancing" in primis) have revolutionized the lives, and a distortion/modification of habits, rhythms, arrangements will continue to be necessary.
\r\n\tGovernments have implemented a series of actions to mitigate the spread of infections and alleviate the consequent pressure on the hospital system. On the other hand, the Covid-19 pandemic has caused a series of other cascading effects that will probably be much more difficult to mitigate and which expose to complex consequences. The past two years have brought many challenges, particularly for healthcare professionals, students, family members of COVID-19 patients, people with mental disorders, the frail, the elderly, and more generally those in disadvantaged socio-economic conditions, and workers whose livelihoods have been threatened. Indeed, the substantial economic impact of the pandemic may hinder progress towards economic growth as well as progress towards social inclusion and mental well-being.
\r\n\t
\r\n\tAlthough in all countries the knowledge on the impact of the pandemic on mental health is still limited and mostly derived from experiences only partially comparable to the current epidemic, such as those referring to the SARS or Ebola epidemics, it is likely that the demand for intervention it will increase significantly in the coming months and years. The extraordinary growth of scientific research in the field of neuroscience now offers the possibility of a new perspective on the relationship between mind and brain and generates new scenarios in understanding the long wave of the pandemic and in the prospects for treatment. Moreover, the pandemic also has led to opportunities to implement remote monitoring and management interventions.
\r\n\t
\r\n\tOverall this volume will address the complex relationship existing between COVID-19, mental health, acquired knowledge, and possible interventions taking a highly multidisciplinary approach; from physiological and psychobiological mechanisms, and neuromodulation through medical treatment, psychosocial interventions, and self-management.
One of the greatest challenges of management is to align and integrate the innumerable elements that constitute the intricate system of organizational processes and, from a broader perspective, being able to assess institutional development based on performance and effectiveness of specific actions on those same elements of the system. However, the boundaries between organizational processes are often ill defined, most of them being highly interdependent and transverse, which makes convergence of efforts and coherent results more difficult to achieve.
Management processes are highly dependent on a parallel and continuous process of decision‐making. Every decision, in turn, depends on the availability of data and information, which is the basis of knowledge construction. In absolute terms, there is not ‘the best’ decision to be taken, as this would require access to the complete and utter repertoire of available data and information about a particular subject—a superhuman intellectual effort would be necessary for processing and synthesizing such amount of information and selecting the best of all possible decisions and their expected causalities. In front of these impossibilities, it is assumed that a general knowledge management program (implicitly included, data and information management processes) is needed to support the decision‐making process, directing knowledge production or recombination for use or reuse in successive decision‐making cycles.
Thus, the greatest dilemma of a decision‐maker at any organizational level is perhaps to reconcile and resolve the balance between analysis and synthesis or, in other words, between reductionist and holistic viewpoints to better understand the system at hand. Even when this dilemma is sorted, there remains the difficulty of operationalizing, both logically and technologically, the relevant management processes.
This chapter presents an ontological approach to organizational systems, here explored in terms of a data and information governance (DIGov) framework for a research and development (R&D) organization. This governance framework encompasses a number of management processes relating to the triad ‘data‐information‐knowledge’.
Section 2 of this chapter offers background information about the organization that served as the context of this study (Brazilian Agricultural Research Corporation—Embrapa), while Sections 3 and 4 present the theoretical foundations of the data and information governance (DIGov) framework and the methods that were used in this research, respectively. Embrapa\'s DIGov model is then explained in Section 5, with the two last sections of the chapter focusing on how the model can be used in practice, with support of knowledge‐map‐inspired conceptual structures (Section 6) and final considerations (Section 7).
The design and implementation of efficient corporate management processes must be supported by a logical, conceptual or even ideological framework, which mediates the causal relations among premises, values, norms and rules, logical and physical structures, costs, personal skills as well as people behaviour and attitudes. All these elements relate to the notion of ‘corporate governance’ [2], which adheres to the organization\'s strategy, therefore differing fundamentally from the ‘management’ system, this one being ultimately focused on operational and tactical issues, such as the monitoring of activities and results achievement.
The Brazilian Agricultural Research Corporation (Embrapa), a large governmental organization, has been developing its own conception of corporate governance. As it is probably the case with many other R&D organizations, Embrapa now finds itself as an immense, diverse and complex organization with its multi‐, inter‐ and transdisciplinary scientific scope; its heterogeneous thematic Research Units spread all over the Brazilian territory; its staff that includes not only scientific researchers but also a wide range of support personnel and experts from many knowledge backgrounds; and its broad stakeholder network, comprised of many sectors such as the State, governments, farmers, academics, students and society as a whole, which are ever more demanding and attentive to the implications of agricultural research, making their voice heard on the most controversial issues (an example is the heated debate and influence of the public opinion on research with Genetically Modified Organisms).
Embrapa is proud to present itself to society as a knowledge‐producer organization—the word ‘knowledge’, in this context, meaning any solution or practical response to a specific demand or problem. It turns out that the knowledge that Embrapa produces is a direct consequence of the alignment of agricultural empirical data and resulting information, which are gathered, processed, shared, reused and disseminated in a dynamic, continuous, cyclical and fed‐back process, aimed at consolidating a certain kind of knowledge that, in turn, inserts more cognitive value into decision‐making. This is not to be seen as a linear process, since it often involves uncertain, unforeseen and even random developments. These general properties of complex systems, inherent to organizations such as Embrapa, have the potential to hinder or delay management decisions, since required data and information are not always timely and easily accessible.
This is not to say that Embrapa\'s data and information management processes are inappropriate or inefficient, nor that correlate governance is missing. It can be said, though, that the input and output flow of information and the chain of activities that make up both Embrapa\'s management and governance processes still leave room for improvement. Particularly, the development of coherent, commonly shared practices of data and information production, sharing, reuse and dissemination is highly desirable as a means to compensate for the traditional, hierarchical organization chart and its many decision‐making structures, where information flows can be greatly impaired by power microstructures and bureaucracy.
Figure 1 illustrates how corporate management processes can benefit from properly managed data, information and knowledge, through improved decision‐making.
Attaching data, information and knowledge to organizational management through the decision‐making process.
Individually considered, the building blocks of Embrapa\'s Data and Information Governance (DIGov) model are not entirely new but relate to a range of previous conceptualizations and notions, which are detailed in Section 4. The DIGov model, however, is not only theoretically informed but also empirically grounded and based upon a deep understanding of Embrapa\'s information environment.
A data gathering plan was built with support of the well‐known 5W2H management tool (What, Why, Where, When, Who, How and How much) and through questionnaires with both closed and open‐ended questions, a large volume of data was gathered, categorized and reciprocally linked, pointing out actors; skills; logical, physical and computational structures; processes, workflows, rules and regulations; stakeholders and even potential or incipient, informal governance sub‐systems.
It can be said, therefore, that this study applied both a deductive and an inductive approach [3], building upon prior knowledge and, at the same time, allowing new themes to emerge from data.
Knowledge mapping was identified as a useful tool for data analysis and representation, allowing for a complete system characterization that appreciated both the conceptual aspects of the entire complex system (level of ideas/macro‐properties) and its instances (level of objects/entities). By doing so, particularities of each component could be explored without losing the sense of the whole.
Empirical data were thematically analysed [4] with support of the qualitative data analysis software Atlas.ti, and to produce a graphic representation of the interrelationships between data elements, these were translated into triple store format, A‐R‐B, where A and B represent the elements or concepts included in the system (entities, objects, facts, etc.), defined by terminological or textual labels; R means the relationship, defined by semantic labels and ‘‐’ can assume uni‐ or bi‐directional paths. The triple stores were gathered and organized in a spreadsheet with three columns and innumerable rows where each row represented one triple.
For allowing the possibility of editing and visualizing a complex conceptual structure (holistic view) and then breaking it into snippets for a more detailed (reductionist) view, the software yEd (https://www.yworks.com/products/yed) was used. Besides generating high‐quality diagrams and visualizations, yEd supports mathematical analysis of social relationships to provide insight into the structure of a social network. Metrics such as density and centralities (betweenness, closeness, degree, etc.), for instance, give a measure of the relevance of a particular element in the whole network.
This section presents the theoretical foundations of the Data and Information Governance (DIGov) framework, exploring underpinning notions and conceptualizations to create a systemic approach to management problems at contemporary organizations, while acknowledging their ontological and complex nature. The notion of information as a complex, social phenomenon, the cognitive itinerary formed by Data‐Information‐Knowledge (DIK) and the conceptual alignment between the DIK life cycles form the basis of the theoretical framework, as explained in the following sections.
The informational environment of an organization can be assumed as a complex system, that is, systems composed of innumerable autonomous but interactive elements, where the result (output) of the system is not simply the sum of the properties and particularities of its parts [5, 6, 7].
Under the systemic perspective [1, 8, 9, 10] and in the context of an organization, the corporate information environment is a social phenomenon [10, 11] and thus can be seen as a complex sub‐system of another complex higher system containing, itself, other complex sub‐systems within itself. As a social phenomenon, information (and, consequently, the data that originates it) assumes institutional properties and causality in the cognitive, communicative, documentary and normative or regulatory dimensions. So, one of the great challenges of complexity, when social sub‐systems are involved, is [12]; since people do not act continuously and regularly in a rational way, nor are they compliant with norms and laws throughout the time, it is not uncommon for them to react in a way not intended or planned by managers and their management strategies or, at least, even if people do not disobey or do not manifest themselves contrary to superior guidelines, they may react inconsistently to corporate guidelines. These inconsistent reactions can meet random, uncertain or unpredictable situations when people are often pressured by the emergency or urgency of requested arrangements and by the huge volume of decision‐making moments they experience in their daily work routines. Due to the complex interactions of these systems and the non‐linear way in which their elements give rise to general behaviour patterns, complex systems can be very difficult to predict, control and manage [1, 8, 9].
It is in this context that data and information governance presents itself as a preventive, conciliatory solution, which is more concerned with guiding premises to foster good practices and less with guaranteeing results in an idealized world of strategic planning processes and deterministic projects.
At R&D institutions, empirical research is an established practice. It means that one of their main concerns is to obtain and translate data into scientific knowledge, which can then be applied to solve real‐world problems. For this itinerary to be complete, an improved understanding of the conceptual line between data, information and knowledge needs to be achieved.
The word ‘information’ is most commonly used to mean physical representations of knowledge: objects, data and documents that possess instructive character, a use that has been previously described as ‘information‐as‐thing’ [13]. Alternatively, the term is used in a wider sense, as in reference to the act of informing or becoming informed (‘information‐as‐process’), or to what we know (‘information‐as‐knowledge’), that is, whatever is perceived in ‘information‐as‐process’. The interrelationship becomes then evident: it is difficult to define ‘knowledge’ without referring to ‘information’, as it is to describe ‘information’ without referring to ‘data’. The following quotes illustrate this:
For taking many forms, both physical and digital, the term data can be difficult to define [16]. Among the most widely cited definitions is the following, from the National Academies of Science:
In practical terms, data are equivalent to a physically ‘recorded symbol’, which can be exemplified by printed characters; binary characters in magnetic, punched or optical form; spoken words; or images. Whatever the physical form may be, it becomes a recorded symbol when it is interpreted as representing something [14]. In the words of Feather and Sturges,
Prior attempts to bring the concepts of data, information and knowledge closer together, in order to identify their boundaries and build a logical trajectory between them can be found in the literature of Cognitive, Information, Management and Computing Sciences. The notion of a Data‐Information‐Knowledge‐Wisdom hierarchy [18] is opportunely recovered here, even though the philosophical discussions and implications arising from it are not addressed [19]. The hierarchical‐pyramidal representation is one of the most influential perspectives, adopted in support of several lines of argumentation [19, 20, 21, 22]. Other more cognitively elaborated appraisals represent the relation in a linear‐progressive form [18]. Despite being conceptually instigating, such representations are criticized from a pragmatic point of view, as to their usefulness in supporting data, information and knowledge management in practice [19]. Conceptually speaking, the main criticism is the reasoning that, if wisdom is to be taken as an ‘unquestionable and irrefutable truth’, it might not be reached if the data supporting it turned out to be incorrect or untrue!
An alternative representation of the relationship between data, information and knowledge is offered in Figure 2. In this new conceptual set up, there is a deliberate preference, based on the logic of added cognitive value, for aligning data, information and knowledge in a circuit with a continuous feedback loop, rather than the conventional hierarchical‐pyramidal or liner‐progressive representations [23].
Data, information and knowledge in a cyclic, continuous feedback circuit. Source: Ref. [
Despite their conceptual interrelatedness, however, ‘data management’, ‘information management’ and ‘knowledge management’ studies have specialized as different bodies of knowledge. Analogously, traditional management approaches in organizations also tend to treat ‘data’, ‘information’ and ‘knowledge’ separately, which might cause considerable confusion, given their high levels of complementarity and interdependence [24, 25].
To overcome this difficulty while building an integrative and systemic approach to data and information governance, these elements were arranged in a conceptual continuum—their interrelation has been acknowledged, so that their use can be maximized in the organization.
In figurative sense, data, information and knowledge are taken here as a quantum triad: depending on the point of observation, what is seen is intellectual energy (thought, idea, cognition), or, alternatively, tangible matter (documents and media, printed or digital), which can then be collected, assembled, organized, analysed, shared, accessed and continuously reused independently of the human brain.
To better represent this perspective, the concepts of data, information and knowledge ‘life cycle’ emerged as a promising solution. Although offered in many different versions in the literature, these life cycles can be used, in a practical way, to support a cyclic, continuous and feedback view of the data, information and knowledge itinerary. Figures 3–5 present examples of data, information and knowledge life cycles (DIK life cycles), as they are central to the understanding of the governance model developed in this chapter.
The data life cycle and its connection with the research process, as proposed by Tenopir et al. [
The information life cycle, according to Floridi [
Knowledge management integrated cycle. Source: Dalkir [
On closer examination, the DIK life cycles seem comparable and have many similarities—which is not surprising, given the conceptual interrelatedness of its elements. Figure 6 was obtained by expanding the conceptions of DIK life cycles that are available in the literature, in order to align and specify the fundamental processes (genesis, creation, production; organization; sharing; access and dissemination; appropriation, validation, evaluation). This is, therefore, a simplified view of the fundamental logic of alignment between these life cycles, here called the ‘DIK Mandala’, which served as a central construct to the concept of governance developed in this work.
The data‐information‐knowledge Mandala.
This integrative look at the data, information and knowledge life cycles has practical significance, since it allows an appreciation of the processes involved in data, information and knowledge management, in terms of specific methodologies and technologies and parallel and progressive arrangements, as presented in Figure 7.
Alignment between data, information and knowledge management processes and activities, as a function of cognitive mechanisms and in relation to technological solutions. Source: Ref. [
The notion of data and information governance retrieves the understanding of governance already adopted in other initiatives of Embrapa, considering as part of a general corporate governance proposal while aligns parallel to other subcategories of organizational governance, such as Information Technology governance, Human Resources governance and so forth. However, against the possible risks of creating an infinite number of instances of governance (reductionist paradigm of the organization), a systemic approach was adopted [8] to sustain the dynamics of information flows within and across organizational subunits, hierarchical levels and governance perspectives. For Embrapa, data and information governance for knowledge means: ‘the determination, systematization and institutionalization of the principles, guidelines, structures, processes, culture, roles and responsibilities that drive, enable and transform data and information management in support of decision‐making and the corporate governance system’.
The notion of ‘governance’ supported here, therefore, is not to be confused with that referring to information technology. On the contrary, it recognizes that problems related to information are often multifaceted—involving behavioural, cultural, regulatory, procedural and structural aspects that are not solved exclusively through the adoption of technological solutions.
As adopted here, data and information governance presents itself as an innovative approach that is situated in a higher and more strategic level than the operational, mechanistic and bureaucratic nature of management processes and technological tools. With constituent, morphological elements (principles, guidelines, structures, processes, cultures, roles and responsibilities) that relate to the corporate information environment, the data and information governance framework can be seen as a fluid, dynamic and aggregating material that permeates, integrates and interacts those elements with each other, assuming (also metaphorically) the ‘physiology’ of the system formed by the corporate management mechanisms, but with enough and sufficient room to deal with non‐linear causalities.
This being said, the difficulty presented for the conception and development of a generic model of data and information governance was precisely to find adequate mechanisms and tools to turn these conceptual ideas into operational pragmatics. A natural way to pragmatize the DIK relation was sought, valuing its ontological nature and acknowledging, in this itinerary, the most logical solution to organize ideas around the corporate informational environment—which, in this particular case, is that of a R&D organization.
The following section presents Embrapa\'s DIGov model, which fills a gap in the literature of Information Science, for pursuing an ontological, systemic and conceptually integrative perspective on the reciprocal relationships of data, information and knowledge management, in the context of R&D organizations.
The DIGov model is shown in Figure 8. Its main constituents and operation or physiology are described as following.
Embrapa\'s DIGov model.
The DIGov model articulates with a series of theoretical, philosophical and conceptual notions, which are available in the literature: ‘information ecology’ [29], ‘information policy’ [30], ‘informational audit’ [31] and ‘information culture’ [32], among others. Some of these precedent approaches have arisen in parallel to the world views derived from or influenced by theories based on relationship or interdependence of system elements and global phenomena, which emerged by the end of World War II and were well consolidated in the 1990s. A creative and timely review and contextualization of the dynamics of human evolution of global knowledge over the past 70 years were presented by Brian Castellani and his work of successive editions of the ‘Map of Complexity Sciences’ (http://www.art‐sciencefactory.com/complexity‐map_feb09.html), where the main theories and scientific approaches are interrelated, as well as their authors. These theories, which support the current itineraries of knowledge that model our understanding of life and the Universe, derive from two main intellectual strands—Systems Science and Cybernetics, both emerging in the second half of the twentieth century. The map registers the convergence of knowledge that today enables us a more systemic and organic view of the world, pointing out General Theory of Systems, Ecological Systems Theory and extending to discussions about complex adaptive systems until including, more recently, the social aspects of the knowledge development process, as in Social Systems Theory, Sociocybernetics and culminating with the e‐Science and Data Science theorizations.
The influence and recovery of those chains of thought into business schools around the world have been previously analysed and contextualized [11], allowing new perspectives to emerge that make such conceptual approaches closer to the pragmatism of organizational management.
It is at this point that ‘sistemism’ [8] arises as one of the main theoretical‐conceptual foundation of the DIGov model. It presents itself as a conciliatory solution between analysis and synthesis, the whole and the parts, holistic representations and reductionist ones, which are inherent to modelling processes, including those of organizational nature. As explained in Section 3, however, the DIGov model not only draws upon a vast theoretical background and the very definition concept adopted in this work, but it is also based upon an empirical analysis of data, information and knowledge management at a R&D organization.
The central axis of the DIGov model is formed by the data, information and knowledge life cycles—in a convergent and interrelated perspective, as explored in detail in the DIK Mandala (Figure 6). ‘Discovery and Creation’, ‘Organization and Processing’, ‘Access and Recovery’ and ‘Dissemination and Communication’ are, therefore, convergent dimensions of the data, information and knowledge life cycles, reflecting the managerial and operational activities that are involved in each phase of these cycles in the various organizational instances and levels. From the data collected at Embrapa, it was observed, however, that these steps, in practice, are not necessarily performed in a linear and sequential way: certain sets of data and information can be produced and immediately made available for ‘access and recovery’; or, still, there are datasets and information that need to be previously organized and treated, for only then be made accessible. The several stages of the data, information and knowledge life cycles can be—and, in some cases, must be—navigated iteratively and non‐sequentially, depending on the nature of the informational asset and corporate interest.
To ensure a continuous improvement of data and information management, however, it is necessary to observe trends and opportunities for improvement, so that the operation of the data, information and knowledge life cycles, which correspond to the DIGov model\'s ‘micro‐level’, must be subject to the following processes, occurring in the ‘meso‐level’: (a) continued monitoring and diagnostics of structures, skills and processes; (b) enrichment and strengthening of the interaction and integration among and between people and information and between those and available technologies; and (c) development and validation of innovations and developments in methodologies and technologies to support data, information and knowledge management.
Finally, complementing the systemic design of the DIGov model, the following components surround and guide the model in a ‘macro‐level’: (i) culture and (ii) social fact, with regard to social aspects and people absorption and application of the model\'s morphology and physiology; (iii) policy, as regards the model\'s legal, regulatory and strategic framework; (iv) technologies; and (v) methodologies.
Knowledge mapping has been presented and discussed as a valuable tool for organizing, representing and retrieving knowledge, being particularly suitable for large amounts of information [33, 34, 35, 36, 37, 38]. The main idea behind knowledge mapping is that facts, entities and objects of any kind can be identified, highlighted and interrelated to each other, in order to solve the deficiencies of documentary languages, which are conventionally based on categorization or classification systems. In DIGov model’s scope, such deficiencies relate to: (a) the need of a conceptual framework for collective cognition and communication enhancement which respects the multidimensional and multifaceted nature of data, information and knowledge and (b) the need of mapping the numerous informational flows, emphasizing both its specific details as their general context in corporate information and knowledge management processes. Thus, knowledge mapping allows the reconciliation of reductionist and holistic paradigms, often conflicting in the choices of tools for organization and representation.
To illustrate the use of this concept and practical tool, a real‐world example will be taken, among many possible ones that relate to data, information and knowledge in support of decision‐making. This will be provided by the Open Access (OA) thematic, which is a recurrent, global demand to Embrapa. Acknowledged as a world reference in tropical agricultural knowledge, Embrapa is invited to present a clear, institutional position and to take practical steps towards OA to the knowledge it produces.
This was one of the main issues to emerge from the questionnaires applied in this research, which was therefore elected as one of the priority topics to be addressed by the company, so as to improve its information and knowledge management processes. In addition to other priority issues (e.g. controlled vocabularies, terminologies, semantic features and its applications; editorial process and policies; research data management; strategic information management, among others), a roadmap was designed to explore and achieve a corporative solution to the OA issue.
From the systemic point of view, which informed the DIGov model construction, a choice of tools was made to better represent this system as a complex one. Such tools are mainly editing software for conceptual structures that would allow the ontological design (concept mapping) of the represented system. In such type of representation, all of the components are assumed to be nodes and their mutual interrelationships are the vertices that connect the nodes to each other, creating a network. Embedded in these networks, it could be assumed that the corporative informational streams flow by the organization morphology (people, structures, processes) and feed its physiology, that is, the way in which an organization develops or operates its activities (
By projecting the DIGov model onto the empirical data and information that was gathered, the following framework was obtained, which forms the basis for the development and application of a knowledge map (Figure 9).
Contextualization of the DIGov model in a network of conceptual, procedural, structural and operational components of Embrapa\'s information environment.
This higher level of abstraction and relational view of knowledge organization can still be useful in exploring the interrelationships of a system\'s components in the more operational level.
Figure 10(A) presents a multidimensional representation of Embrapa\'s data and information management panorama, mapping its main elements, as empirically observed. The large volume of data collected through the questionnaires was interconnected and their mutual interrelationships (causalities) were registered. Figure 10(B) highlights the contextualization of the OA issue in relation to the overall conceptual structure.
Conceptual representation of Embrapa\'s data and information management panorama (A), highlighting the positioning of the Open Access issue in relation to the other elements of the system (B).
This exercise needs not to be complete and final. Being a complex system, its breadth, diversity and dynamism imposes the need of a model (and, consequently, of a representation tool) that meets the system\'s plasticity and allows its continued modification, due to uncertainties, randomness and unpredictabilities that characterizes the organizational time and space. However, features of this dynamics can be evidenced and captured to assist their operational management.
Figure 11 focuses on the concept of OA, isolating it from the whole it belongs to and highlighting the most relevant and immediate relationships that it establishes with other elements of the system.
Apartness of the Open Access concept, identifying the most important relationships it establishes with other elements of Embrapa\'s informational environment.
The final stage of this exercise is to do with making concrete sense of this mapping, drawing it together with the relevant management processes. This is an intellectual, human oriented exercise, but which can be assisted by relevant tools. Doing so, the map presented in Figure 11 can be graphically edited and semantically refined to incorporate a qualitative view of the positioning of the OA issue within Embrapa\'s informational environment, by identifying the elements that compose the DIGov model and designing causal relationships between them to recommend operational actions, whether to change culture and behaviour or to improve methodologies, structures or supporting technologies.
A semantic refinement of the relationships drawn in the model can and should be systematized and standardized corporately, strengthening a collectively agreed language process to ensure that the corporate learning processes become more aligned from cognitive, procedural, normative and communicational points of views. This would then result into the design that is shown in Figure 12—a pragmatic governance proposal to support decision‐making regarding this particular issue in the corporate context.
Snippet view (zoom in) of the ontological structure of Embrapa\'s DIGov model, focusing the Open Access issue within the corporate information environment.
As already mentioned, corporate management processes are inherently aligned with the decision‐making process. It was also mentioned that the best decision to be made is always dependent on the assessment of possible alternatives, which are formed by the gathering and analysis of data, information and knowledge relating to the matter of interest.
Given the complexity of R&D organizations’ information environment, conventional models of data, information and knowledge organization and representation, which are conventionally of the categorization or classification types (metadata systems and taxonomies, for example), have proven to limit the effectiveness of information search and retrieval, disambiguation and making sense processes. In other words, relational models such as the thesauri, multi‐faceted taxonomies, semantic networks and ontologies are more appropriate options for supporting conceptual designs that can better represent the ontological nature and the multidimensionality of causal relations in a complex system [11, 39].
Recent studies have reiterated [33] knowledge mapping as an important tool for knowledge management, since they increase the recognition, systematization, communication and sharing of common corporate practices. Despite being a promising area in the fields of conceptual modelling and tools’ development, the operational adoption of knowledge maps still presents shortcomings. The present chapter contributes to filling this knowledge gap, while proposing a method for modelling complex, organizational processes. Furthermore, modelling data and information governance in R&D organizations such as Embrapa, with support of knowledge mapping, has still the following advantages:
Knowledge maps are very useful when the immensity and diversity of data and information involved in a given analysis need to be structured from vast content where the encoding of the tacit knowledge has already been processed, for example, textually.
Knowledge maps do not need to be exhaustive. In fact, they are not committed to representing the real world. Complex systems are dynamic, mutants, reactive to externalities and therefore difficult to be modelled, and, therefore, they require tools which respect their natural plasticity and which, from an operational point of view, can be easily adjusted both in relation to its component elements and in relation to the nature of interrelationships that such elements establish among themselves.
Knowledge maps are also useful tools for inferring on the social networks implicitly contained in organizational complexity. The identification of social networks come to meet the need to enhance the social fact in the context of organizational management, recognizing its importance and the way people influence and are influenced by corporate management actions. This utility of knowledge maps can be used in support of systemic approaches [8], which have as a first general methodological rule, the commandment to put the social fact in its broader context, that is, its own system [40].
Knowledge mapping (the process) or knowledge maps (the products) are useful for meaningfully representing data, information and knowledge, where and when large amounts of data, information and knowledge are involved. Embrapa\'s DIGov model, as presented in this work, suggests that this process and its products can be usefully employed as a conceptual and computational model for organizing and managing extensive corporate contents. But far beyond organizing data, information and knowledge repositories, knowledge mapping can be a useful tool and basic framework for navigational purposes through corporate informational flows supporting organizational and collective intelligence applications.
Future avenues of work for the further development, implementation and use of Embrapa\'s DIGov model would be:
To evolve the governance proposal in parallel with efforts to incite the desired organizational culture change, towards one that would include the understanding, absorbing and embedding of complex and system thinking as new paradigms, in support of data and information management processes.
To evolve conventional methods of data and information management, which are still predominantly based upon uni‐ or bi‐dimensional models of knowledge organization systems (KOS) [41] like term lists, taxonomies, categorization or classification schemes, for example, to multidimensional relationships models like thesauri, semantic networks and ontologies, which are more suitable for operationally rearrange knowledge content of large volume and high potential for use and reuse in processes of collective intelligence and institutional development.
Air pollution is one of the major global public health concerns. This has been reflected in the recently published report by the World Health Organization (WHO) that, only 10% of people live in cities, which conforms with the WHO air quality guideline. What is shocking is that air pollution causes death of one person in every nine people annually, and outdoor air pollution on its own is causing deaths of 3 million people every year [1]. It is also worth noting that, air pollutants in urban areas can be contributed by local sources and long-range transport of air masses [2, 3, 4], for instance, transport of dust mass from Gobi desert to East Asia [5, 6, 7] and from Sahara desert to Europe [8, 9]. These urban aerosols have been reported by a number of authors [10, 11] to have ecotoxicities that are potential for causing health problems [12, 13, 14].
So far, China is the fastest-growing country in the world with a pace which has never been seen before. This growth is partially contributed by heavy investments in manufacturing industries for different kinds of products. This has got an impact on air pollution as most of these industries to use coal as one of the major sources of power; the habitual use of coal for heating in the households by rural dwellers also contributes to the impacts [15, 16]. Besides, lifestyle changes caused by the change of economic status like the increase in the number of vehicles as it can be seen in most of the Chinese cities, to a greater extent worsen the air quality for the country. This has reinforced the Chinese government to make efforts in mitigating air pollution problems, which include the enactment of a stringent law (National Ambient Air Quality Standard (NAAQS)) in 2012 to curb the emission of air pollutants. The NAAQS stipulates the hourly, daily, and annual standards of NO2, SO2, CO, O3, PM10, and PM2.5; the PM10 and PM2.5 stand for particulate matter with the aerodynamic diameter of less than 10 microns and 2.5 microns, respectively. So far, a number of studies on boundary layer structure, which is the main determinant of air pollutants, are available online [3, 4, 17, 18, 19, 20, 21]. Apart from the pioneer studies [22, 23, 24, 25] on pollutants forecast by using large-scale circulations, little has been done on this area which is the key for planning and in managing pollutants. This chapter aims at highlighting the linkage between urban aerosol distribution and large-scale circulation, which are potential for forecasting pollutants.
In order to establish the relationship between the pollutants and the AAOI, Singular Value Decomposition (SVD) analysis was used to determine covariance of Geopotential height (GPH) and BLSI. The study by Bretherton
The leading mode of the singular value decomposition (SVD) of geopotential height (GPH) and boundary layer structure index (BLSI) showing (a) Average boundary layer structure index from December 2014 to February 2015 (DJF
Based on the established covariance of GPH–SVD and BLSI–SVD on the subsection above, it is evident that the AAOI has significant influence on the BLSI which at the end determines pollutants distribution. This subsection, therefore, correlated the average of June and July AAOI (JJ–AAOI) (i.e. boreal summer) with the average dust surface mass concentration of PM2.5 of November to February (boreal winter). This dust mass concentration of PM2.5 is the product of MERRA-2 atmospheric reanalysis which has been assimilated with ground and satellite observation. An assessment study on MERRA-2 surface dust mass concentration of PM2.5 by He et al. [31] reveals a significant correlation with surface measured PM2.5 over the Yangtze River Basin (YRB). Similar consistent observation between surface measured and MERRA-2 data (dust surface mass concentration of PM2.5) has also been reported in North China by Song et al. [32]. Therefore, MERRA-2 data are reliable for studying air pollution. It is also worth noting that, November is not a winter month but during this period of time the concentration of PM2.5 is higher, similar to what is experienced during the winter months (December, January, and February (DJF)). Therefore, November was included in the analysis as the winter month to capture its feedback mechanism of AAOI. A previous study by Fan and Wang [30] on the Antarctic oscillation (AAO) and dust weather frequency found that there was a significant correlation between AAO of DJF and surface air temperature in North China.
The average dust surface mass concentration of PM2.5 over the area (115° E–125° E and 30°N–40° N) which showed a significant correlation with the AAOI was determined and used to develop the time series of pollutants with the AAOI. The determined correlation coefficient on this area was 0.42, which is significant at a 95% confidence level. A closer look at the time series of AAOI (Figure 2), showed a consistent lead–lag effect except in the two scenarios (from 1988/1989 to 1993/1994 and 2013/2014 to 2017/2018) where the trends were not obvious. The observed trends which were not obvious are thought to be so because pollutants distribution over the area is determined by more than one system thus there is a possibility that other influential systems were stronger during this period of time than the effect of AAOI. For instance, a study by Chen and Wang [33] suggested the weakened northerly winds and the growth of inversion anomalies in the lower part of the troposphere and the weakened trough over East Asia to be the reason for haze occurrence. So, whenever one of the factors of this inter-dependable system changes, the whole system will behave differently from its normal behavior.
Time series of average dust mass surface concentration of PM2.5 over the area (115°E–125° E and 30°N–40°N) during winter (November to February of the following year) and the average of June and July Antarctic oscillation index (JJ–AAOI) from the year 1980 to 2018. The lead–lag relationship is consistent except in the two scenarios (1988/1989 to 1993/1994 and 2013/2014 to 2017/2018).
Further, the ability of the June and July AAOI (JJ–AAOI) in describing the changes in winter dust mass concentration of PM2.5 and its potential for forecasting pollutants were tested. The linear regression method was used to develop the prediction equation for the dust surface mass concentration of PM2.5 over the region which showed a positive correlation with the AAOI. The dust surface mass concentration of PM2.5 of zonal (115° E–125° E, 30° N–40° N) region was de-trended and used to develop the anomaly time series of PM2.5 concentration. The data set of thirty years [30] from 1980 to 2009 was used to train the system and to formulate the forecasting equation while the data from 2010 to 2007 was used to run the prediction eq. Among the different models (linear, quadratic, cubic, exponential, and logarithmic) which were tested, the linear equation model was found to be the best model (Figure not shown). The developed linear regression equation was modified by adding a percentage error to the training data set and generating a new regression equation. This procedure was repeated several times until the percentage error was reduced, and a more convincing equation was generated. Note that, whenever the process is repeated, new coefficients were generated for the forecast Equation. A number of studies have also used the linear regression equation to forecast weather and climate parameters [34, 35, 36]. The best linear regression equation was;
The dependent variable (
The predicted trend was almost the same with the measured values of the anomaly of dust surface mass concentration of PM2.5 (Figure 3), even though the magnitude of the values differs. The forecast equation predicted higher values in 3 cases than the anomaly of the actual values. The developed regression equation shows the potential of prediction as it can explain about 60% of the anomaly of the surface dust mass concentration over northeast China. Nevertheless, there was a difference between observed and predicted anomaly values (see Figure 3) because the dust surface mass concentration of PM2.5 does not entirely depend on one factor, thus, small discrepancies suggest the influence of other determining factors. Not only that but also the region (115° E–125° E, 30° N–40° N) covered by the average data is huge, so small changes in the dust mass concentration can result in a large discrepancy. Nevertheless, the correlation coefficient (
Prediction ability test of the linear regression equation for the anomaly of average dust surface mass concentration of PM2.5 for winter (November to February) using the average of June and July Antarctic oscillation index (JJ–AAOI) from the year 2010 to 2017.
For obtaining some more insights and the possible mechanisms that may be the causative agents, the AAOI, and the Antarctic Sea ice were studied. The correlation results of the AAOI and the Antarctic Sea ice concentration show that there is a significant correlation (at 90% confidence level) between them even though the area which shows a significant correlation decreases as the lead–lag time increases (Figure 4a–g). This is because the Antarctic Sea ice distribution is significantly influenced by atmospheric pressure than other factors such as temperature and wind [37, 38, 39, 40]. It is worth noting that, the AAO is also defined based on the GPH anomalies. Nevertheless, the area which shows significant correlation changes with the time of the year (i.e. each month) shows different correlation results. Results from Figure 4a and b suggest that August and September are the most significant months because large areas over the Antarctica region show a significant correlation during these two months.
Correlation map between the average of June and July Antarctic oscillation index (JJ–AAOI) and the Antarctic Sea ice over for the months (a) August (b) September (c) October (d) November (e) December (f) January (g) February for the period of 36 years (i.e. the year 1982–2017). The red (blue) color shows the area with a positive (negative) correlation with JJ–AAOI at a 90% confidence level.
Similarly, previous studies [41, 42] showed that the AAO signal normally tends to lead the climate anomalies by two to three months (one season). Likewise, a study by Carleton [39] revealed that the indices (Southern Oscillation Index (SOI), Trans-Polar Index (TPI)) over SH leads the Antarctic Sea ice for more than four months. The key areas identified in August and September were five [5]; the first area was between 30°E–50°E and 59.5°S–62°S, the second area was between 90°E–110°E and 57.5°S–61.5°S, the third area was between 110°E–170°E and 61°S–64°S, the fourth area was between 110°W–140°W and 65°S–68°S, and the fifth area was between 40°W–60°W and 59°S–65°S. Similar areas of Sea ice were determined in the study by Wu and Zhang [43] to have a strong influence on the atmosphere. The first, second, and fourth key areas showed a positive correlation with AAOI while the third and fifth areas showed a negative correlation. Interestingly, Figure 4c and d show that, during the austral spring season (October and November), the size of the areas which showed a significant correlation (positive and negative) has been reduced. The reduced areas indicate that the influence of stored signals is reduced with time. Similarly, Figure 4e–g show the austral summer season (December, January, and February), in which the areas were further reduced and reached their minimum level at the end of February (Figure 4g). Concurrent results have been reported by Gupta and England [38] on their study of coupled ocean–atmosphere−ice response to variation in SAM (AAO) and by Hall and Visbeck [40] on their study on variability of SH Sea ice from AAO. The finding suggests that the anomalies of the AAOI in June and July can be stored at Antarctic Sea ice before it influences the ABLS which at the end determines the distribution and concentration of dust surface mass concentration of PM2.5 over East and North China. The signal of the AAOI can be imprinted and transmitted through the ice-sea-air system. Since the atmosphere on itself cannot store long memory due to the nature of atmospheric waves which most of the time are chaotic [42, 44, 45, 46], there is a need for the medium which can store this memory, such as the Sea ice. Therefore, the AAOI influences the boundary layer through the ice−sea−atmosphere interaction. Similar interaction of the ice−sea−atmosphere has been revealed by Yuan and Li [37] to be the most important interaction, which affects the atmospheric pressure and temperature. This lead–lag phenomenon is feasible because the observed atmospheric feedback mechanism is shorter than the atmospheric circulation of Rossby waves to travel from the Southern Hemisphere (SH) to the Northern Hemisphere (NH). Similar lead–lag time has been reported by Shen and Mickley [47] in the study of the effects of ENSO on summertime ozone pollution in the eastern United States. The subsection below used the key areas of Antarctic Sea ice to define a new ice index aiming at quantifying the influence of ice concentration on dust surface mass concentration.
In order to encounter the weight contribution of different areas within the same month, the regression analysis was performed. Figure 5 shows the weight contribution of five key areas, where the highest contribution was found to be originated at 30°E–50°E and 59.5°S–62°S with the weight of eight-folds, while the lowest contribution originated at 40°W–60°W and 59°S–65°S with the contribution of negative three folds.
The average weight contribution of five key different regions for August to October for 36 years (i.e. the year 1982–2017). The red (blue) color shows the area with positive (negative) weight contribution of the key areas.
This weighting contribution was used to develop the ice index which was then correlated with AAOI; the correlation coefficient found was 0.6 and it was significant at a 99% confidence limit. The observed correlation is reasonable as AAOI has the tendency of regulating Sea ice through atmospheric, oceanic, and dynamic forcing over the Antarctica area [37, 38, 48]. Also, the difference in weight contribution suggests that the anomalies over the five correlated areas of Antarctica did not contribute equally to the observed trend of PM2.5 distribution. Moreover, the ice index developed showed a significant correlation at a 90% confidence limit with the dust surface mass concentration of PM2.5 around East and North China (Figure not shown). These observed results imply that, apart from other contributing factors, the Antarctic Sea ice plays a key role in determining the distribution of the pollutants over East and North China. At this juncture, one of the difficult questions that could arise is how does the dynamics over the Antarctic influence the pollutants on the other side of the hemisphere? One of the possible reasons that could be used to explain the occurrence of this mechanism is through the actions of wind. Furthermore, the correlation map of zonal and meridional winds with the ice index also showed a significant correlation over East and North China (Figure 6).
The correlation map between the average of August to October Antarctic Sea ice index and the average zonal and meridional wind (average of November to February) at 850 hPa from 1981 to 2018. The marked areas passed the significance correlation test at a 90% confidence level.
Moreover, Figure 6 shows that the eastern and northern parts of China acted as the center of the cyclone, which favors the accumulation of pollutants from the high-pressure zone. A similar observation was reported by Liang and Wang [49] that, East Asia Jetstream (EAJ) is the dominant wind field in China. Therefore, this area acted as the convergence zone of pollutants from different areas. It was found that in this area, wind was originated from far areas such as the northern part of India. Likewise, as presented in Figure 6, this region is under the influence of southerly anomalies which resulted in the decline of clean and moist wind from the northern part. Moreover, the stronger southerly and weaker northerly anomaly has been reported to weaken East Asia winter monsoon [50]. This condition is thought to generate stable atmospheric conditions; a favorable condition for pollutants accumulation. This observation indicates that the higher August to October Sea ice index causes the southerly wind to be stronger while the northerly wind becomes weaker. A similar observation was reported by a number of authors [24, 33] that, higher August, September, and October AAO (ASO–AAO) cause weaker northerly winds over North China.
The correlation coefficient between the JJ–AAOI and the average zonal (80° E–130° E) zonal wind shows significant zonal dipole pattern, with the positive phase in mainland China. The selection of a small area is done purposely in order to capture the detailed information at a fine-scale from the global data. The averaging of these data is intended to minimize the effect which may be caused by the mesoscale phenomena. At the altitudes of 1000 hPa and 850 hPa, there are positively correlated areas over the Taklamakan desert; the size of the correlated area is decreasing with the altitude (Figure 7a and b). This observation suggests that the zonal wind at lower altitudes up to 500 hPa at the area around desert regions was decreasing with the altitude. That means, the higher JJ–AAOI corresponds to the higher low-level wind speeds which may result in the generation of dust and therefore increase the dust surface mass concentration of PM2.5. Different from what was observed at 1000 hPa, the East China Sea was observed to have a significant negative correlation at the altitude of 200 hPa (Figure 7d). Therefore, this shows that the zonal wind from East China Sea decreased, hence little moist and cleaner air was allowed to enter mainland China.
Correlation coefficient between averaged zonal (80°E–130°E) zonal wind at (a) 1000 hPa (b) 850 hPa (c) 500 hPa (d) 200 hPa and average of June and July Antarctic oscillation index (JJ
The lead–lag timescale of two months is feasible as revealed in the previous study by Fan and Wang [22] which also found that, dust-related circulations have a timescale of 30 to 60 days from SH to North China. Yuan and Li [37] reported a delayed response of two months from the Sea ice to large-scale atmospheric circulations. Not only these studies but also a study by Qin et al. [51] found a good correlation between April–May AAOI and summer (July–August) rainfall over North China. Similarly, the study by Yuan et al. [48] reveals that the positive phase of AAO during boreal spring can determine the late summer precipitation over North China. The lead–lag time between the positive phase of AAO and summer precipitation is about six months. Therefore, these previous studies further complement the feasibility of two months lead–lag mechanism between the pollutants and the anomaly over SH i.e. the anomalies of the Antarctic Sea ice and the JJ–AAOI. These results signify the need to further contemplate the potential of predicting the status of PM2.5 dust surface mass concentration at least two months in advance; for the purpose of air quality management. Similar suggestion of using AAO in predicting the following season was unveiled by a number of authors [41, 42, 46, 52].
Moreover, the latitude−altitude section for slopes of average zonal (80°E–130°E) meridional wind over mainland China and the average of September and October AAOI (SO–AAOI) (Figure 8a), shows a similar scenario to what has been portrayed in Figure 7. There is AAO like structure below the altitude of 850 hPa and positive anomalies at the altitude between 600 hPa and 70 hPa in SH at around 40°S and 60°S of the Equator (Figure 8a). Over the mainland China, there were positive anomalies below the altitude of 500 hPa with the center at around 850 hPa. At the equator, negative anomalies were observed below the altitude of 400 hPa. Similarly, the slope of zonal wind shows AAO like structure between 40°S and 60°S throughout the troposphere, with the positive anomalies area extending to the stratosphere (Figure 8b). Over the NH, there was a dipole like structure from 10° N to 80° N. As it has been the case for zonal and meridional winds, the slope of AAOI and GPH also show an AAO like structure (Figure 9) in the SH and the dipole like structure in the NH. The positive anomalies over mainland China were found between the pressure level of 700 hPa and 100 hPa. It is worth noting that, the dipole-like structure observed in NH was centered at around 200 hPa in almost all cases i.e. the height of the dominant EAJ. As it has been put forward by previous studies [48, 49], EAJ is important in determining the weather condition for mainland China.
Latitude-altitude section for slopes of September and October Antarctic oscillation index (SO–AAOI) and mean zonal (80°E–130°E) of (a) meridional (v) wind (b) zonal (u) wind. The abscissa represents latitude while the ordinate represents pressure levels. The marked areas passed the significance test at a 90% confidence level.
Latitude-altitude section for slopes of September and October Antarctic oscillation index (SO−AAOI) and mean zonal (80°E–130°E) geopotential height. The abscissa represents latitude while the ordinate represents pressure levels. The marked areas passed the significance test at a 90% confidence level.
The observed characteristics of the slope of AAOI with the GPH, zonal and meridional winds are clearly seen in Figure 6, which shows the correlation map indicating the most significant area being between 20°N and 50°N, and 100°E and 125°E. Therefore, this implies that the actions of winds and the influence of AAOI can potentially affect the distribution of pollutants over most parts of mainland China. Corroborated results have been reported by Fan and Wang [22, 30] study on dust in North China, Zheng et al. [42] study on the seasonal influence of AAOI on precipitation, and Wang and Fan [53] study on the linkage between southern hemisphere zonal wind and East Asian summer monsoon circulation. In general, these studies indicate that the possible mechanism of the linkage between Antarctic and NH is based mainly on meridional teleconnection.
It is well established in the literature that, large-scale circulation in both, SH and NH affects the climate and weather patterns of China and Asia as well. So in order to get an insight into the possible mechanisms as to how the climatic factors influence the distribution of the pollutants over China, empirical orthogonal functions (EOFs) was used to decompose the variability of winter dust surface mass concentration of PM2.5 (November, December, January and February) from 1980 to 2018. As it has been pointed out in the previous subsection, November is also included in the analysis because it was found to be highly polluted during the winter months, therefore, its inclusion is necessary for capturing the broader picture of what is happening during the high pollutants periods. Figure 10a and b show the first EOF (EOF1) and second EOF (EOF2) loading of the dust mass surface concentration of PM2.5, respectively. The EOF1 explains 40% of the original loading of surface dust mass concentration of PM2.5 anomaly which shows a swath of a positive anomaly over the northwest and eastern part of China (Figure 10a). A previous study by Bian et al. [5] linked the dust pollution in eastern China with this high loading area identified by EOF1 as in this area, there is the largest desert in China (i.e. Taklamakan desert) and the Gobi desert. A study on the estimates of the ground concentration of PM2.5 based on satellite-derived aerosol optical depth by Ma et al. [54] also indicated the Tarim Basin (i.e. Taklamakan desert) and Gobi desert similar to what has been identified by EOF1 as the potential sources of PM2.5 in China. Elsewhere, Galindo et al. [8] found a high concentration of crustal element in PM10 samples in Italy during dust outbreaks in Sahara desert. Therefore, this substantiates that, these deserts can generate both coarse and fine particles causing high loading of PM2.5 dust mass concentration. A different scenario was observed on EOF2 which explains 29% of the total variance of dust mass concentration of PM2.5 because some parts of the central and northern areas showed a negative correlation (Figure 10b). That is, the area which was identified to explain much of the loading by EOF1 showed a negative correlation in EOF2 different from what was reported in the previous studies [5, 54]. This finding can be partially contributed by the small variance explained by EOF2 as compared to the one of EOF1. The maximum spatial loadings of EOF1 are found at 35°N–42°N and 75°E–110°E and the average spatial loading are found at around 22°N–40°N and 110°E–125°E. Time series of decomposed surface dust mass concentration of PM2.5 for the leading principal component (PC1) and second principal component (PC2) are as shown in Figure 11a and b, respectively. Before 1992, the time series of PC1 showed the four years wave train of negative and positive values (+, −, +) before it maintained the decadal negative value from 1997 to 2007. A different scenario was observed in the time series of PC2 as it showed a bi-decadal mode of negative values before the year 2000 and positive values after the year 2000 except in the year 2008 when it was negative. The value of PC2 post the year 2000 and the year 2009 have a time scale of eight and nine years of consecutive positive values, respectively. With due consideration to scant information from the variation trend of EOF2, this study did not consider EOF2 for further analysis. This is, therefore, suggested to provide the area of focus for other researchers to explore further on what is the possible association between EOF2 and the distribution of the pollutants.
The loading of Empirical orthogonal function (EOF) of average dust surface mass concentration of PM2.5 during winter season (November to February) from 1980 to 2018 across China (a) EOF1 (b) EOF2.
Normalized detrended time series of decomposed average dust surface mass concentration of PM2.5 during the winter season (November to February) from 1980 to 2018 (a) Leading principal component (PC1) (b) Second principal component (PC2).
Since, EOF1 explains much variance of dust mass concentration of PM2.5 during winter (Figure 10a), the correlation amongst climatic factors of boreal autumn (September and October) and PC1 were used to identify key areas with the influence on pollutants distribution in China. Figure 12 shows the correlation coefficient results between averaged zonal (80°E–130°E) zonal wind at different altitudes (1000 hPa, 850 hPa, 500 hPa, and 200 hPa) and PC1. The analysis of the results from the correlation map of PC1 and zonal wind showed significant zonal positive and negative tripole (+, −, +) patterns in the meridional direction. The center of negative correlation at 1000 hPa and 850 hPa is at East China Sea around 22°N and 125°E (Figure 12a and b). The negatively correlated area which was around East China Sea was observed to shift inland at 500 hPa and disappeared at 200 hPa (Figure 12c and d). The positive correlation in mainland China at 1000 hPa and 850 hPa was centered on the position of Taklamakan desert (40°N and 95°E) while for the upper level (500 hPa and 200 hPa) it was centered at 30°N and 95°E (Figure 12c and d). Observed significant zonal positive and negative dipole propagation suggests the influence of zonal wind in propagating the signals to mid-latitude.
Correlation map of the leading principal component (PC1) and averaged zonal (80°E–130°E) zonal wind at (a) 1000 hPa (c) 850 hPa (e) 500 hPa (g) 200 hPa. The marked areas passed the significant test at 90% confidence level.
Figure 13a shows the composite difference of meridional circulation between the years of high and low-AAOI. The high and low years were selected after multiplying the standard deviation by 0.5 of standardized JJ–AAOI. The year 1979, 1984, 1985, 1989, 1993, 1998, 2004, 2010, 2015, and 2016 were selected as the years of high positive JJ–AAOI, while the years 1991, 1992, 1996, 1997, 2005, 2007, and 2009 were selected as the years of low negative JJ–AAOI. Similarly, Figure 13b shows the composite difference of meridional circulation between high and low PC1 years. The high and low years were also selected after multiplying the standard deviation by 0.5 of standardized PC1. The years with positive high (negative low) PC1 were 1983, 1985, 1991, 1992, 1995, 2008, 2009, 2011, and 2012 (1979, 1980, 1988, 1990, 1997, 1998, 2000, 2004, and 2005). The shadings which are seen on these figures (i.e. Figure 13a and b) denote the climatology average of June and July vertical velocity (i.e. omega). A careful look at these figures show the ascending motions are from the equator to around 40°N and descending motion at around 60°S and 20°N. The observed intensification of the westerlies at around 60°S and 75°S during the high AAOI years has been reported in previous studies [40, 52]. Since the global meridional circulations in both SH and NH are connected and share ascending air mass branches, therefore, the meridional circulation changes in SH will also affect the circulations in NH. The results from these figures show that the significant ascending and southerly anomalies exhibit around 25°N and 35°N during the positive JJ–AAOI years. That is to say, the higher PC1 is concurrent with the overlaying ascending southerly anomaly which is in one way or another endorsed by the positive phase of JJ–AAO. These observed scenarios during the positive phase of AAO are favorable for pollutant accumulation.
Composite difference of September and October meridional circulation between high and low (a) June and July AAOI years (b) PC1. The shaded area represents the climatology vertical velocity (omega) with the units of 1% Pa/s while the black vector represents the composite difference which reaches 90% confidence level for student t-test.
The linkage between large-scale circulation and the pollutants distribution was studied using the correlation map of AAOI and dust surface mass concentration of PM2.5 over mainland China. The area which was found to have a significant correlation was normalized and used to develop a time series of dust mass concentration. The correlation coefficient between time series of dust mass concentration of PM2.5 and AAOI was 0.42; significant at 95% confidence level. The lead–lag trend of the time series of pollutants and the JJ–AAOI was consistent except on two occasions (1988/89 to 1993/94 and 2013/14 to 2017/18). The inconsistency in these two occasions indicates that another prominent system was leading the AAO. On top of this, most of the high and low AAOI years did not fall within these two occasions which also support the existence of other influencing system signifying that pollutants distribution does not depend on only one factor. Moreover, the JJ–AAOI was found to have a good correlation with the Antarctic Sea ice concentration in the leading months over the key areas which were: 30°E–50°E and 59.5°S–62°S, 90°E–110°E and 57.5°S–61.5°S, 110°E–170°E and 61°S–64°S, 110°W–140°W and 65°S–68°S, and 40°W–60°W and 59°S–65°S. The correlation coefficient of ice index developed from the regression analysis of the key areas with AAOI was 0.6 and significant at 99% indicating that the signals of AAOI are imprinted on Antarctic Sea ice before affecting the ABL and dust mass concentration. It should be noted that mainland China acts as the center of the cyclone (convergence zone). The persistence of the positive phase of J
Moreover, EOF1 was found to explain 40% of the total variability of dust mass concentration of PM2.5 over mainland China. This is indicated by a swath of positive anomaly over the northeast particularly over the Taklamakan and Gobi Desert as well as eastern part of the country. The maximum spatial loading of EOF1 centered at around 35°N–42°N and 75°E–110°E and 22°N–40°N and 110°E–125°E; these areas are potential sources for dust mass before they find their way to the atmosphere through wind. Contrary, EOF2 which explains 29% of the total variability showed a negative correlation with dust mass concentration of PM2.5 over potential sources identified by EOF1 which indicates that different mechanisms control dust mass concentration. EOF2 results could be partially contributed by its small variance. Furthermore, time series of decomposed dust mass concentration of PM2.5 for the PC1 revealed a four years wave train of positive and negative values (+, −, +) before the year 1992 and the decadal negative train after the year 1997; the trend is concurrent with the calculated high and low year of PC1. The time series of PC2 indicates the existence of a bi-decadal mode of negative values before the year 2000, and a positive value after, except in the year 2008 where there was a negative value. PC1 showed a significant zonally positive correlation with the zonal wind and negative tripole (+, −, +) pattern in the meridional direction. The positively correlated regions over mainland China were centered at Taklamakan desert (40°N and 95°E) as was the case for AAOI analysis. The zonal positive and negative pattern indicates that zonal wind influenced the propagation of signals to mid-latitude. Moreover, the composite difference of meridional wind among the years of high and low June AAOI and also the year of high and low PC1, showed that the significant ascending and southerly anomalies exhibit at around 25°N and 35°N during the years with high J
Edited by Jan Oxholm Gordeladze, ISBN 978-953-51-3020-8, Print ISBN 978-953-51-3019-2, 336 pages,
\nPublisher: IntechOpen
\nChapters published March 22, 2017 under CC BY 3.0 license
\nDOI: 10.5772/61430
\nEdited Volume
This book serves as a comprehensive survey of the impact of vitamin K2 on cellular functions and organ systems, indicating that vitamin K2 plays an important role in the differentiation/preservation of various cell phenotypes and as a stimulator and/or mediator of interorgan cross talk. Vitamin K2 binds to the transcription factor SXR/PXR, thus acting like a hormone (very much in the same manner as vitamin A and vitamin D). Therefore, vitamin K2 affects a multitude of organ systems, and it is reckoned to be one positive factor in bringing about "longevity" to the human body, e.g., supporting the functions/health of different organ systems, as well as correcting the functioning or even "curing" ailments striking several organs in our body.
\\n\\nChapter 1 Introductory Chapter: Vitamin K2 by Jan Oxholm Gordeladze
\\n\\nChapter 2 Vitamin K, SXR, and GGCX by Kotaro Azuma and Satoshi Inoue
\\n\\nChapter 3 Vitamin K2 Rich Food Products by Muhammad Yasin, Masood Sadiq Butt and Aurang Zeb
\\n\\nChapter 4 Menaquinones, Bacteria, and Foods: Vitamin K2 in the Diet by Barbara Walther and Magali Chollet
\\n\\nChapter 5 The Impact of Vitamin K2 on Energy Metabolism by Mona Møller, Serena Tonstad, Tone Bathen and Jan Oxholm Gordeladze
\\n\\nChapter 6 Vitamin K2 and Bone Health by Niels Erik Frandsen and Jan Oxholm Gordeladze
\\n\\nChapter 7 Vitamin K2 and its Impact on Tooth Epigenetics by Jan Oxholm Gordeladze, Maria A. Landin, Gaute Floer Johnsen, Håvard Jostein Haugen and Harald Osmundsen
\\n\\nChapter 8 Anti-Inflammatory Actions of Vitamin K by Stephen J. Hodges, Andrew A. Pitsillides, Lars M. Ytrebø and Robin Soper
\\n\\nChapter 9 Vitamin K2: Implications for Cardiovascular Health in the Context of Plant-Based Diets, with Applications for Prostate Health by Michael S. Donaldson
\\n\\nChapter 11 Vitamin K2 Facilitating Inter-Organ Cross-Talk by Jan O. Gordeladze, Håvard J. Haugen, Gaute Floer Johnsen and Mona Møller
\\n\\nChapter 13 Medicinal Chemistry of Vitamin K Derivatives and Metabolites by Shinya Fujii and Hiroyuki Kagechika
\\n"}]'},components:[{type:"htmlEditorComponent",content:'This book serves as a comprehensive survey of the impact of vitamin K2 on cellular functions and organ systems, indicating that vitamin K2 plays an important role in the differentiation/preservation of various cell phenotypes and as a stimulator and/or mediator of interorgan cross talk. Vitamin K2 binds to the transcription factor SXR/PXR, thus acting like a hormone (very much in the same manner as vitamin A and vitamin D). Therefore, vitamin K2 affects a multitude of organ systems, and it is reckoned to be one positive factor in bringing about "longevity" to the human body, e.g., supporting the functions/health of different organ systems, as well as correcting the functioning or even "curing" ailments striking several organs in our body.
\n\nChapter 1 Introductory Chapter: Vitamin K2 by Jan Oxholm Gordeladze
\n\nChapter 2 Vitamin K, SXR, and GGCX by Kotaro Azuma and Satoshi Inoue
\n\nChapter 3 Vitamin K2 Rich Food Products by Muhammad Yasin, Masood Sadiq Butt and Aurang Zeb
\n\nChapter 4 Menaquinones, Bacteria, and Foods: Vitamin K2 in the Diet by Barbara Walther and Magali Chollet
\n\nChapter 5 The Impact of Vitamin K2 on Energy Metabolism by Mona Møller, Serena Tonstad, Tone Bathen and Jan Oxholm Gordeladze
\n\nChapter 6 Vitamin K2 and Bone Health by Niels Erik Frandsen and Jan Oxholm Gordeladze
\n\nChapter 7 Vitamin K2 and its Impact on Tooth Epigenetics by Jan Oxholm Gordeladze, Maria A. Landin, Gaute Floer Johnsen, Håvard Jostein Haugen and Harald Osmundsen
\n\nChapter 8 Anti-Inflammatory Actions of Vitamin K by Stephen J. Hodges, Andrew A. Pitsillides, Lars M. Ytrebø and Robin Soper
\n\nChapter 9 Vitamin K2: Implications for Cardiovascular Health in the Context of Plant-Based Diets, with Applications for Prostate Health by Michael S. Donaldson
\n\nChapter 11 Vitamin K2 Facilitating Inter-Organ Cross-Talk by Jan O. Gordeladze, Håvard J. Haugen, Gaute Floer Johnsen and Mona Møller
\n\nChapter 13 Medicinal Chemistry of Vitamin K Derivatives and Metabolites by Shinya Fujii and Hiroyuki Kagechika
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Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. 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Patil Medical College and Director, Centre for Advanced Medical Research (CAMR), BLDE (Deemed to be University), Vijayapur, Karnataka, India. Dr. Das did his M.S. and Ph.D. in Human Physiology from the University of Calcutta, Kolkata. His area of research is focused on understanding of molecular mechanisms of heavy metal activated low oxygen sensing pathways in vascular pathophysiology. He has invented a new method of estimation of serum vitamin E. His expertise in critical experimental protocols on vascular functions in experimental animals was well documented by his quality of publications. He was a Visiting Professor of Medicine at University of Leeds, United Kingdom (2014-2016) and Tulane University, New Orleans, USA (2017). For his immense contribution in medical research Ministry of Science and Technology, Government of India conferred him 'G.P. Chatterjee Memorial Research Prize-2019” and he is also the recipient of 'Dr.Raja Ramanna State Scientist Award 2015” by Government of Karnataka. He is a Fellow of the Royal Society of Biology (FRSB), London and Honorary Fellow of Karnataka Science and Technology Academy, Department of Science and Technology, Government of Karnataka.",institutionString:"BLDE (Deemed to be University), India",institution:null},{id:"243660",title:"Dr.",name:"Mallanagouda Shivanagouda",middleName:null,surname:"Biradar",slug:"mallanagouda-shivanagouda-biradar",fullName:"Mallanagouda Shivanagouda Biradar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243660/images/system/243660.jpeg",biography:"M. S. Biradar is Vice Chancellor and Professor of Medicine of\nBLDE (Deemed to be University), Vijayapura, Karnataka, India.\nHe obtained his MD with a gold medal in General Medicine and\nhas devoted himself to medical teaching, research, and administrations. He has also immensely contributed to medical research\non vascular medicine, which is reflected by his numerous publications including books and book chapters. Professor Biradar was\nalso Visiting Professor at Tulane University School of Medicine, New Orleans, USA.",institutionString:"BLDE (Deemed to be University)",institution:{name:"BLDE University",country:{name:"India"}}},{id:"289796",title:"Dr.",name:"Swastika",middleName:null,surname:"Das",slug:"swastika-das",fullName:"Swastika Das",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/289796/images/system/289796.jpeg",biography:"Swastika N. Das is Professor of Chemistry at the V. P. Dr. P. G.\nHalakatti College of Engineering and Technology, BLDE (Deemed\nto be University), Vijayapura, Karnataka, India. She obtained an\nMSc, MPhil, and PhD in Chemistry from Sambalpur University,\nOdisha, India. Her areas of research interest are medicinal chemistry, chemical kinetics, and free radical chemistry. She is a member\nof the investigators who invented a new modified method of estimation of serum vitamin E. She has authored numerous publications including book\nchapters and is a mentor of doctoral curriculum at her university.",institutionString:"BLDEA’s V.P.Dr.P.G.Halakatti College of Engineering & Technology",institution:{name:"BLDE University",country:{name:"India"}}},{id:"248459",title:"Dr.",name:"Akikazu",middleName:null,surname:"Takada",slug:"akikazu-takada",fullName:"Akikazu Takada",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248459/images/system/248459.png",biography:"Akikazu Takada was born in Japan, 1935. After graduation from\nKeio University School of Medicine and finishing his post-graduate studies, he worked at Roswell Park Memorial Institute NY,\nUSA. He then took a professorship at Hamamatsu University\nSchool of Medicine. In thrombosis studies, he found the SK\npotentiator that enhances plasminogen activation by streptokinase. He is very much interested in simultaneous measurements\nof fatty acids, amino acids, and tryptophan degradation products. By using fatty\nacid analyses, he indicated that plasma levels of trans-fatty acids of old men were\nfar higher in the US than Japanese men. . He also showed that eicosapentaenoic acid\n(EPA) and docosahexaenoic acid (DHA) levels are higher, and arachidonic acid\nlevels are lower in Japanese than US people. By using simultaneous LC/MS analyses\nof plasma levels of tryptophan metabolites, he recently found that plasma levels of\nserotonin, kynurenine, or 5-HIAA were higher in patients of mono- and bipolar\ndepression, which are significantly different from observations reported before. In\nview of recent reports that plasma tryptophan metabolites are mainly produced by\nmicrobiota. He is now working on the relationships between microbiota and depression or autism.",institutionString:"Hamamatsu University School of Medicine",institution:{name:"Hamamatsu University School of Medicine",country:{name:"Japan"}}},{id:"137240",title:"Prof.",name:"Mohammed",middleName:null,surname:"Khalid",slug:"mohammed-khalid",fullName:"Mohammed Khalid",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/137240/images/system/137240.png",biography:"Mohammed Khalid received his B.S. degree in chemistry in 2000 and Ph.D. degree in physical chemistry in 2007 from the University of Khartoum, Sudan. He moved to School of Chemistry, Faculty of Science, University of Sydney, Australia in 2009 and joined Dr. Ron Clarke as a postdoctoral fellow where he worked on the interaction of ATP with the phosphoenzyme of the Na+/K+-ATPase and dual mechanisms of allosteric acceleration of the Na+/K+-ATPase by ATP; then he went back to Department of Chemistry, University of Khartoum as an assistant professor, and in 2014 he was promoted as an associate professor. In 2011, he joined the staff of Department of Chemistry at Taif University, Saudi Arabia, where he is currently an assistant professor. His research interests include the following: P-Type ATPase enzyme kinetics and mechanisms, kinetics and mechanisms of redox reactions, autocatalytic reactions, computational enzyme kinetics, allosteric acceleration of P-type ATPases by ATP, exploring of allosteric sites of ATPases, and interaction of ATP with ATPases located in cell membranes.",institutionString:"Taif University",institution:{name:"Taif University",country:{name:"Saudi Arabia"}}},{id:"63810",title:"Prof.",name:"Jorge",middleName:null,surname:"Morales-Montor",slug:"jorge-morales-montor",fullName:"Jorge Morales-Montor",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/63810/images/system/63810.png",biography:"Dr. Jorge Morales-Montor was recognized with the Lola and Igo Flisser PUIS Award for best graduate thesis at the national level in the field of parasitology. He received a fellowship from the Fogarty Foundation to perform postdoctoral research stay at the University of Georgia. He has 153 journal articles to his credit. He has also edited several books and published more than fifty-five book chapters. He is a member of the Mexican Academy of Sciences, Latin American Academy of Sciences, and the National Academy of Medicine. He has received more than thirty-five awards and has supervised numerous bachelor’s, master’s, and Ph.D. students. Dr. Morales-Montor is the past president of the Mexican Society of Parasitology.",institutionString:"National Autonomous University of Mexico",institution:{name:"National Autonomous University of Mexico",country:{name:"Mexico"}}},{id:"217215",title:"Dr.",name:"Palash",middleName:null,surname:"Mandal",slug:"palash-mandal",fullName:"Palash Mandal",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/217215/images/system/217215.jpeg",biography:null,institutionString:"Charusat University",institution:null},{id:"49739",title:"Dr.",name:"Leszek",middleName:null,surname:"Szablewski",slug:"leszek-szablewski",fullName:"Leszek Szablewski",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49739/images/system/49739.jpg",biography:"Leszek Szablewski is a professor of medical sciences. He received his M.S. in the Faculty of Biology from the University of Warsaw and his PhD degree from the Institute of Experimental Biology Polish Academy of Sciences. He habilitated in the Medical University of Warsaw, and he obtained his degree of Professor from the President of Poland. Professor Szablewski is the Head of Chair and Department of General Biology and Parasitology, Medical University of Warsaw. Professor Szablewski has published over 80 peer-reviewed papers in journals such as Journal of Alzheimer’s Disease, Biochim. Biophys. Acta Reviews of Cancer, Biol. Chem., J. Biomed. Sci., and Diabetes/Metabol. Res. Rev, Endocrine. He is the author of two books and four book chapters. He has edited four books, written 15 scripts for students, is the ad hoc reviewer of over 30 peer-reviewed journals, and editorial member of peer-reviewed journals. Prof. Szablewski’s research focuses on cell physiology, genetics, and pathophysiology. He works on the damage caused by lack of glucose homeostasis and changes in the expression and/or function of glucose transporters due to various diseases. He has given lectures, seminars, and exercises for students at the Medical University.",institutionString:"Medical University of Warsaw",institution:{name:"Medical University of Warsaw",country:{name:"Poland"}}},{id:"173123",title:"Dr.",name:"Maitham",middleName:null,surname:"Khajah",slug:"maitham-khajah",fullName:"Maitham Khajah",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/173123/images/system/173123.jpeg",biography:"Dr. Maitham A. Khajah received his degree in Pharmacy from Faculty of Pharmacy, Kuwait University, in 2003 and obtained his PhD degree in December 2009 from the University of Calgary, Canada (Gastrointestinal Science and Immunology). Since January 2010 he has been assistant professor in Kuwait University, Faculty of Pharmacy, Department of Pharmacology and Therapeutics. His research interest are molecular targets for the treatment of inflammatory bowel disease (IBD) and the mechanisms responsible for immune cell chemotaxis. He cosupervised many students for the MSc Molecular Biology Program, College of Graduate Studies, Kuwait University. Ever since joining Kuwait University in 2010, he got various grants as PI and Co-I. He was awarded the Best Young Researcher Award by Kuwait University, Research Sector, for the Year 2013–2014. He was a member in the organizing committee for three conferences organized by Kuwait University, Faculty of Pharmacy, as cochair and a member in the scientific committee (the 3rd, 4th, and 5th Kuwait International Pharmacy Conference).",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"195136",title:"Dr.",name:"Aya",middleName:null,surname:"Adel",slug:"aya-adel",fullName:"Aya Adel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/195136/images/system/195136.jpg",biography:"Dr. Adel works as an Assistant Lecturer in the unit of Phoniatrics, Department of Otolaryngology, Ain Shams University in Cairo, Egypt. Dr. Adel is especially interested in joint attention and its impairment in autism spectrum disorder",institutionString:"Ain Shams University",institution:{name:"Ain Shams University",country:{name:"Egypt"}}},{id:"94911",title:"Dr.",name:"Boulenouar",middleName:null,surname:"Mesraoua",slug:"boulenouar-mesraoua",fullName:"Boulenouar Mesraoua",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94911/images/system/94911.png",biography:"Dr Boulenouar Mesraoua is the Associate Professor of Clinical Neurology at Weill Cornell Medical College-Qatar and a Consultant Neurologist at Hamad Medical Corporation at the Neuroscience Department; He graduated as a Medical Doctor from the University of Oran, Algeria; he then moved to Belgium, the City of Liege, for a Residency in Internal Medicine and Neurology at Liege University; after getting the Belgian Board of Neurology (with high marks), he went to the National Hospital for Nervous Diseases, Queen Square, London, United Kingdom for a fellowship in Clinical Neurophysiology, under Pr Willison ; Dr Mesraoua had also further training in Epilepsy and Continuous EEG Monitoring for two years (from 2001-2003) in the Neurophysiology department of Zurich University, Switzerland, under late Pr Hans Gregor Wieser ,an internationally known epileptologist expert. \n\nDr B. Mesraoua is the Director of the Neurology Fellowship Program at the Neurology Section and an active member of the newly created Comprehensive Epilepsy Program at Hamad General Hospital, Doha, Qatar; he is also Assistant Director of the Residency Program at the Qatar Medical School. \nDr B. Mesraoua's main interests are Epilepsy, Multiple Sclerosis, and Clinical Neurology; He is the Chairman and the Organizer of the well known Qatar Epilepsy Symposium, he is running yearly for the past 14 years and which is considered a landmark in the Gulf region; He has also started last year , together with other epileptologists from Qatar, the region and elsewhere, a yearly International Epilepsy School Course, which was attended by many neurologists from the Area.\n\nInternationally, Dr Mesraoua is an active and elected member of the Commission on Eastern Mediterranean Region (EMR ) , a regional branch of the International League Against Epilepsy (ILAE), where he represents the Middle East and North Africa(MENA ) and where he holds the position of chief of the Epilepsy Epidemiology Section; Dr Mesraoua is a member of the American Academy of Neurology, the Europeen Academy of Neurology and the American Epilepsy Society.\n\nDr Mesraoua's main objectives are to encourage frequent gathering of the epileptologists/neurologists from the MENA region and the rest of the world, promote Epilepsy Teaching in the MENA Region, and encourage multicenter studies involving neurologists and epileptologists in the MENA region, particularly epilepsy epidemiological studies. \n\nDr. Mesraoua is the recipient of two research Grants, as the Lead Principal Investigator (750.000 USD and 250.000 USD) from the Qatar National Research Fund (QNRF) and the Hamad Hospital Internal Research Grant (IRGC), on the following topics : “Continuous EEG Monitoring in the ICU “ and on “Alpha-lactoalbumin , proof of concept in the treatment of epilepsy” .Dr Mesraoua is a reviewer for the journal \"seizures\" (Europeen Epilepsy Journal ) as well as dove journals ; Dr Mesraoua is the author and co-author of many peer reviewed publications and four book chapters in the field of Epilepsy and Clinical Neurology",institutionString:"Weill Cornell Medical College in Qatar",institution:{name:"Weill Cornell Medical College in Qatar",country:{name:"Qatar"}}},{id:"282429",title:"Prof.",name:"Covanis",middleName:null,surname:"Athanasios",slug:"covanis-athanasios",fullName:"Covanis Athanasios",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/282429/images/system/282429.jpg",biography:null,institutionString:"Neurology-Neurophysiology Department of the Children Hospital Agia Sophia",institution:null},{id:"190980",title:"Prof.",name:"Marwa",middleName:null,surname:"Mahmoud Saleh",slug:"marwa-mahmoud-saleh",fullName:"Marwa Mahmoud Saleh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/190980/images/system/190980.jpg",biography:"Professor Marwa Mahmoud Saleh is a doctor of medicine and currently works in the unit of Phoniatrics, Department of Otolaryngology, Ain Shams University in Cairo, Egypt. She got her doctoral degree in 1991 and her doctoral thesis was accomplished in the University of Iowa, United States. Her publications covered a multitude of topics as videokymography, cochlear implants, stuttering, and dysphagia. She has lectured Egyptian phonology for many years. Her recent research interest is joint attention in autism.",institutionString:"Ain Shams University",institution:{name:"Ain Shams University",country:{name:"Egypt"}}},{id:"259190",title:"Dr.",name:"Syed Ali Raza",middleName:null,surname:"Naqvi",slug:"syed-ali-raza-naqvi",fullName:"Syed Ali Raza Naqvi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259190/images/system/259190.png",biography:"Dr. Naqvi is a radioanalytical chemist and is working as an associate professor of analytical chemistry in the Department of Chemistry, Government College University, Faisalabad, Pakistan. Advance separation techniques, nuclear analytical techniques and radiopharmaceutical analysis are the main courses that he is teaching to graduate and post-graduate students. In the research area, he is focusing on the development of organic- and biomolecule-based radiopharmaceuticals for diagnosis and therapy of infectious and cancerous diseases. Under the supervision of Dr. Naqvi, three students have completed their Ph.D. degrees and 41 students have completed their MS degrees. He has completed three research projects and is currently working on 2 projects entitled “Radiolabeling of fluoroquinolone derivatives for the diagnosis of deep-seated bacterial infections” and “Radiolabeled minigastrin peptides for diagnosis and therapy of NETs”. He has published about 100 research articles in international reputed journals and 7 book chapters. Pakistan Institute of Nuclear Science & Technology (PINSTECH) Islamabad, Punjab Institute of Nuclear Medicine (PINM), Faisalabad and Institute of Nuclear Medicine and Radiology (INOR) Abbottabad are the main collaborating institutes.",institutionString:"Government College University",institution:{name:"Government College University, Faisalabad",country:{name:"Pakistan"}}},{id:"58390",title:"Dr.",name:"Gyula",middleName:null,surname:"Mozsik",slug:"gyula-mozsik",fullName:"Gyula Mozsik",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/58390/images/system/58390.png",biography:"Gyula Mózsik MD, Ph.D., ScD (med), is an emeritus professor of Medicine at the First Department of Medicine, Univesity of Pécs, Hungary. He was head of this department from 1993 to 2003. His specializations are medicine, gastroenterology, clinical pharmacology, clinical nutrition, and dietetics. His research fields are biochemical pharmacological examinations in the human gastrointestinal (GI) mucosa, mechanisms of retinoids, drugs, capsaicin-sensitive afferent nerves, and innovative pharmacological, pharmaceutical, and nutritional (dietary) research in humans. He has published about 360 peer-reviewed papers, 197 book chapters, 692 abstracts, 19 monographs, and has edited 37 books. He has given about 1120 regular and review lectures. He has organized thirty-eight national and international congresses and symposia. He is the founder of the International Conference on Ulcer Research (ICUR); International Union of Pharmacology, Gastrointestinal Section (IUPHAR-GI); Brain-Gut Society symposiums, and gastrointestinal cytoprotective symposiums. He received the Andre Robert Award from IUPHAR-GI in 2014. Fifteen of his students have been appointed as full professors in Egypt, Cuba, and Hungary.",institutionString:"University of Pécs",institution:{name:"University of Pecs",country:{name:"Hungary"}}},{id:"277367",title:"M.Sc.",name:"Daniel",middleName:"Martin",surname:"Márquez López",slug:"daniel-marquez-lopez",fullName:"Daniel Márquez López",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/277367/images/7909_n.jpg",biography:"Msc Daniel Martin Márquez López has a bachelor degree in Industrial Chemical Engineering, a Master of science degree in the same área and he is a PhD candidate for the Instituto Politécnico Nacional. His Works are realted to the Green chemistry field, biolubricants, biodiesel, transesterification reactions for biodiesel production and the manipulation of oils for therapeutic purposes.",institutionString:null,institution:{name:"Instituto Politécnico Nacional",country:{name:"Mexico"}}},{id:"196544",title:"Prof.",name:"Angel",middleName:null,surname:"Catala",slug:"angel-catala",fullName:"Angel Catala",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/196544/images/system/196544.jpg",biography:"Angel Catalá studied chemistry at Universidad Nacional de La Plata, Argentina, where he received a Ph.D. in Chemistry (Biological Branch) in 1965. From 1964 to 1974, he worked as an Assistant in Biochemistry at the School of Medicine at the same university. From 1974 to 1976, he was a fellow of the National Institutes of Health (NIH) at the University of Connecticut, Health Center, USA. From 1985 to 2004, he served as a Full Professor of Biochemistry at the Universidad Nacional de La Plata. He is a member of the National Research Council (CONICET), Argentina, and the Argentine Society for Biochemistry and Molecular Biology (SAIB). His laboratory has been interested for many years in the lipid peroxidation of biological membranes from various tissues and different species. Dr. Catalá has directed twelve doctoral theses, published more than 100 papers in peer-reviewed journals, several chapters in books, and edited twelve books. He received awards at the 40th International Conference Biochemistry of Lipids 1999 in Dijon, France. He is the winner of the Bimbo Pan-American Nutrition, Food Science and Technology Award 2006 and 2012, South America, Human Nutrition, Professional Category. In 2006, he won the Bernardo Houssay award in pharmacology, in recognition of his meritorious works of research. Dr. Catalá belongs to the editorial board of several journals including Journal of Lipids; International Review of Biophysical Chemistry; Frontiers in Membrane Physiology and Biophysics; World Journal of Experimental Medicine and Biochemistry Research International; World Journal of Biological Chemistry, Diabetes, and the Pancreas; International Journal of Chronic Diseases & Therapy; and International Journal of Nutrition. He is the co-editor of The Open Biology Journal and associate editor for Oxidative Medicine and Cellular Longevity.",institutionString:"Universidad Nacional de La Plata",institution:{name:"National University of La Plata",country:{name:"Argentina"}}},{id:"186585",title:"Dr.",name:"Francisco Javier",middleName:null,surname:"Martin-Romero",slug:"francisco-javier-martin-romero",fullName:"Francisco Javier Martin-Romero",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSB3HQAW/Profile_Picture_1631258137641",biography:"Francisco Javier Martín-Romero (Javier) is a Professor of Biochemistry and Molecular Biology at the University of Extremadura, Spain. He is also a group leader at the Biomarkers Institute of Molecular Pathology. Javier received his Ph.D. in 1998 in Biochemistry and Biophysics. At the National Cancer Institute (National Institute of Health, Bethesda, MD) he worked as a research associate on the molecular biology of selenium and its role in health and disease. After postdoctoral collaborations with Carlos Gutierrez-Merino (University of Extremadura, Spain) and Dario Alessi (University of Dundee, UK), he established his own laboratory in 2008. The interest of Javier's lab is the study of cell signaling with a special focus on Ca2+ signaling, and how Ca2+ transport modulates the cytoskeleton, migration, differentiation, cell death, etc. He is especially interested in the study of Ca2+ channels, and the role of STIM1 in the initiation of pathological events.",institutionString:null,institution:{name:"University of Extremadura",country:{name:"Spain"}}},{id:"217323",title:"Prof.",name:"Guang-Jer",middleName:null,surname:"Wu",slug:"guang-jer-wu",fullName:"Guang-Jer Wu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/217323/images/8027_n.jpg",biography:null,institutionString:null,institution:null},{id:"148546",title:"Dr.",name:"Norma Francenia",middleName:null,surname:"Santos-Sánchez",slug:"norma-francenia-santos-sanchez",fullName:"Norma Francenia Santos-Sánchez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/148546/images/4640_n.jpg",biography:null,institutionString:null,institution:null},{id:"272889",title:"Dr.",name:"Narendra",middleName:null,surname:"Maddu",slug:"narendra-maddu",fullName:"Narendra Maddu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/272889/images/10758_n.jpg",biography:null,institutionString:null,institution:null},{id:"242491",title:"Prof.",name:"Angelica",middleName:null,surname:"Rueda",slug:"angelica-rueda",fullName:"Angelica Rueda",position:"Investigador Cinvestav 3B",profilePictureURL:"https://mts.intechopen.com/storage/users/242491/images/6765_n.jpg",biography:null,institutionString:null,institution:null},{id:"88631",title:"Dr.",name:"Ivan",middleName:null,surname:"Petyaev",slug:"ivan-petyaev",fullName:"Ivan Petyaev",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Lycotec (United Kingdom)",country:{name:"United Kingdom"}}},{id:"423869",title:"Ms.",name:"Smita",middleName:null,surname:"Rai",slug:"smita-rai",fullName:"Smita Rai",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Integral University",country:{name:"India"}}},{id:"424024",title:"Prof.",name:"Swati",middleName:null,surname:"Sharma",slug:"swati-sharma",fullName:"Swati Sharma",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Integral University",country:{name:"India"}}},{id:"439112",title:"MSc.",name:"Touseef",middleName:null,surname:"Fatima",slug:"touseef-fatima",fullName:"Touseef Fatima",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Integral University",country:{name:"India"}}},{id:"424836",title:"Dr.",name:"Orsolya",middleName:null,surname:"Borsai",slug:"orsolya-borsai",fullName:"Orsolya Borsai",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca",country:{name:"Romania"}}},{id:"422262",title:"Ph.D.",name:"Paola Andrea",middleName:null,surname:"Palmeros-Suárez",slug:"paola-andrea-palmeros-suarez",fullName:"Paola Andrea Palmeros-Suárez",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Guadalajara",country:{name:"Mexico"}}}]}},subseries:{item:{id:"13",type:"subseries",title:"Plant Physiology",keywords:"Plant Nutrition, Plant Hormone, Photosynthesis, Respiration, Plant Stress, Multi-omics, High-throughput Technology, Genome Editing",scope:"Plant Physiology explores fundamental processes in plants, and it includes subtopics such as plant nutrition, plant hormone, photosynthesis, respiration, and plant stress. In recent years, emerging technologies such as multi-omics, high-throughput technologies, and genome editing tools could assist plant physiologists in unraveling molecular mechanisms in specific critical pathways. The global picture of physiological processes in plants needs to be investigated continually to increase our knowledge, and the resulting technologies will benefit sustainable agriculture.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/13.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11409,editor:{id:"332229",title:"Prof.",name:"Jen-Tsung",middleName:null,surname:"Chen",slug:"jen-tsung-chen",fullName:"Jen-Tsung Chen",profilePictureURL:"https://mts.intechopen.com/storage/users/332229/images/system/332229.png",biography:"Dr. Jen-Tsung Chen is currently a professor at the National University of Kaohsiung, Taiwan. He teaches cell biology, genomics, proteomics, medicinal plant biotechnology, and plant tissue culture. Dr. Chen\\'s research interests include bioactive compounds, chromatography techniques, in vitro culture, medicinal plants, phytochemicals, and plant biotechnology. 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