FS2004 aircraft‐simulated characteristics PREADAR MQ‐1.
\r\n\tHealth and mental health issues of both children and adults and evidence-based treatments will be included. The types of sexual violence that occur and prevention efforts that have – or have not – been made to address the occurrence of these types of violence will be covered.
\r\n\r\n\tCultural and governmental policies, as well as legal and jurisdiction issues to address victims of these crimes, will also be incorporated in the book. For instance, Meagan’s Law and its worthiness in protecting children will be incorporated as well as the Federal program to reimburse victims of online child pornography and the legal entanglements and ramifications of that program.
\r\n\r\n\tThe typology of offenders and the effectiveness of treatment will also be addressed.
\r\n\tFinally, the direction of prevention strategies, treatment needs for both victims and offenders, and policy issues to move the field forward, particularly in terms of research, will be presented. The field of sexual violence has made significant strides in the past 45 years in terms of understanding sexually deviant behavior, the impact on children who then experience the symptoms of that trauma in adulthood, how to effectively interview sexually victimized children, and finally, treatment and social mores that make disclosure possible and recovery hopeful.
In reality, all physical systems are affected by uncertainties due to modeling errors, parametric variation, and external disturbances. Controlling of dynamical systems in the presence of uncertainties is extremely difficult as the controller\'s performances degrade and the system may even be led to instability. As such, active researches are continuing to develop controllers that can work successfully in spite of uncertainties. Robust control techniques such as nonlinear adaptive control, model predictive control, backstepping and sliding mode control [1, 2, 3, 4, 5, 11, 19, 20, 32, 34] have been evolved to deal with uncertainties.
The classical Sliding Mode Control (SMC) leads, generally, to the appearing of an undesirable chattering phenomenon [2, 3, 9, 10, 13, 14, 15] to solve this problem we propose an approach using the Adaptive Integral High Order Sliding Mode Controller (AIHOSMC). This technique ensures a good tradeoff between error and robustness against noise and especially a good accuracy for a certain frequency range, regardless of the gain setting of the algorithm. This technique is based on estimating the successive derivatives of the sliding mode surface and transmitting them to the control block, all by using an aircraft in virtual simulated environments [24, 25]. It is real‐time virtual simulation, which is close to the real‐world situation.
The piloting technique proposed in this work is more robust and simpler to implement than the quaternion one. It only requires information about the sliding mode surface.
Through a methodology based on the confrontation of the real and the simulated worlds, the main objective of this chapter is to develop an autopilot based on a robust controller to maintain the desired trajectory (Figure 1).
Real trajectory.
To achieve this objective, we use the flight simulator FS2004 as a simulated world environment coupled to a hardware and a software development platform. This simulator is developed by Microsoft, with several simulated aircraft included in its airplane library. We choose the Predator MQ‐1 (Figure 2). It is considered as a reconnaissance and an intelligent system.
The predator MQ‐1 flying in FS‐2004.
In this work, the main goal is to maintain the desired aircraft\'s trajectory; and to do so, we propose the following approach:
description and analysis of the aircraft system model;
implementation of a real‐time interface between the flight simulator FS2004 and the module real‐time Windows target of Simulink/Matlab;
development and implementation of the piloting law based on adaptive integral sliding mode for the design of the autopilot controller;
flight tests.
The MQ‐1 predator is an American unmanned aerial vehicle (UAV) that can serve in the reconnaissance or attack role. Predator has been in the United States Air Force (USAF) service since 1995 and has seen combat in numerous theatres.
Airwrench tool gives access to flight dynamic characteristics (http://www.mudpond.org/AirWrench_main.htm). This tool allows creating and tuning flight dynamics files description of simulated planes models. This software uses aerodynamics formulas and equations described on the Mudpond Flight Dynamics Workbook. It calculates aerodynamic coefficients based on the physical characteristics and performance of the aircraft (Table 1).
Dimensions | Moments of inertia |
---|---|
Length: 11.88 m | Pitch: 1800.0 |
Wingspan: 14.84 m | Roll: 3700.00 |
Wing surface area: 11.43 m2 | Yaw: 1800.00 |
Wing root chord: 1.55 m | Cross: 0.00 |
Aspect ratio: 19.28 | |
Taper ratio: 0.10 |
FS2004 aircraft‐simulated characteristics PREADAR MQ‐1.
We communicate with FS2004 by using a dynamic link library called FSUIPC.dll (Flight Simulator Universal Inter‐Process Communication). This library created by Peter Dowson and is downloadable from his website [36] (
To read or write a variable using the FSUIPC, we need to know its offset address, its format, and the necessary conversions. For example, the bank angle (
Offset | Name | Var. type | Size (octet) | Usage |
---|---|---|---|---|
057C | Bank angle ( | S32 | 4 | Degree |
578 | Elevation angle ( | S32 | 4 | Degree |
580 | Head angle ( | U32 | 4 | Degree |
02BC | Speed IAS ( | S32 | 4 | Knot*128 |
0BB2 | Elevator deflection ( | S16 | 2 | -16383 to +16383 |
0BB6 | Aileron deflection ( | S16 | 2 | -16383 to +16383 |
0BBA | Rudder deflection ( | S16 | 2 | -16383 to +16383 |
088C | Thrust control ( | S16 | 2 | -16383 to +16383 |
Flight parameters in the buffer FSUIPC.
To deal with the design of an autopilot controller, we propose an environment framework based on a software in the loop (SIL) methodology (see Figure 3) and we use Microsoft flight simulator (MSFS‐2004) as a plane simulation environment [24, 25].
Software‐in‐the‐loop architecture.
This work is a real‐time virtual simulation, we read or/and write the desired parameters from and to MSFS‐2004 through the computer memory by using the FSUIPC library.
The model describing the system is presented by [12, 25, 26]
with is the aircraft state vector in the body frame:
We propose the following output vector:
The nonlinear functions
where,
where
The coefficients
Expression of the modified aerodynamic coefficients.
Consider the following nonlinear uncertain system [31]
The uncertainties in
The
is called “
With
With
Functions
The
With
Consider the following state feedback control
with
Applying Eq. (13) to system (10), one gets
The control objective is now the following: how to define a discontinuous control law ensuring the stabilization of the previous system, in a finite time and in spite of the uncertainties?
We proposed two high‐order sliding mode controllers based on integral sliding mode concept [27]: the first requires knowledge of the uncertainties bounds, whereas, for the second one, no knowledge of the bounds is required. This latter feature is due to an adaptation law for the control gain.
The following theorem proposes a continuous finite time stabilizing feedback controller for a chain of integrators, by giving an explicit construction involving a small parameter. One gets an asymptotically stable closed‐loop system; the system is homogeneous of negative degree with respect to a suitable dilation, which implies the finite time stability. Consider the system (12) with no uncertainty (
Let
With
For
Consider the following function, named “integral sliding variable,” defined as (
with the term
This latter feature is a key point of the integral sliding mode controller; in fact, the definition of the integral sliding variable allows to ensure that a sliding mode has been established early from the initial time, thanks to the finite time convergence property of
From the previous inequality, it is clear that, if the control
Then, in order to stabilize system (15), the following control law is defined
This controller has two parts:
The first one
The second one
ensures the establishment of a
The relative degrees are
The input control
We propose the integral sliding variable as follows:
where
In Theorem 1, we choose
The integrators’ chain is defined by
where,
The control input can be chosen as
where
The reduction of the noise is assumed by the presence of the linear term (
The dynamic adaptation of the gains
The application of this piloting technique in FS2004 is shown in Figure 2.
The input signals at the upper and lower saturation values of the control laws are used to respect the actuators bounds. Scaled functions are added to take into account the actuators resolutions.
The adaptive integral high‐order sliding mode technique is used to recover the desired signal. Several flight tests were realized to demonstrate the effectiveness of the combined controller/integrators’ chain.
We run the flight simulator FS2004 and the interface with the module real‐time windows target of Simulink/Matlab.
In a first step, we used aircraft predator, the aircraft taking off was done using the keyboard. Then, we run our software to transmit the control inputs based on the adaptive integral higher‐order sliding mode to the autopilot controller in order to maintain the desired trajectory.
The desired signal injected and the output integrators’ chain are shown in Figure 4. We notice the outputs of the integrators’ chain
Application of the adaptive integral high order sliding mode controller in FS2004.
Reference and output integrators.
Figure 6 shows the error between the output integrators’ chain
Surface sliding mode
The input signals at the upper and the lower saturation values of the aileron, rudder, and elevator deflections are used to respect the virtual Joystick (PPjoy) bounds. Upper limit: 62767, lower limit: 1.
Airwrench gives the following data:
Aileron parameters: Aileron area 1.70 m2, aileron up angle limit 20.0°, aileron down angle limit 15.0°.
Elevator parameters: Elevator area 1.54 m2, elevator up angle limit 25.00°, elevator down angle limit 20.00°.
Rudder parameters: Rudder area 0.62 m2, Rudder angle limit 24.00°.
The aileron, elevator, and rudder deflections are shown in Figures 7–9. We notice the absence of the chattering phenomenon.
Ailler control.
Rudder control.
Elevator control.
The evolution parameters
Dynamic parameters evolution
The flight tests demonstrate the robustness of the adaptive integral high‐order sliding mode. It makes it possible to ensure a better derivation of the desired input signal in real time, and this is to ensure a good accuracy of tracking the desired trajectory.
In this chapter, a procedure of the communication with an aircraft model in a simulated environment and the implementation of the real‐time interface between the Microsoft flight simulator and the module “real‐time windows target” of Simulink/Matlab has been presented. After that, an adaptive integral sliding mode for an aircraft autopilot has been presented. Our approach uses the environment simulator (FS2004) to reduce the design process complexity.
For the piloting part, we have interested the gain adaptation for the reduction of chattering phenomena and possibility to control the aircraft presented by the uncertain nonlinear systems in which the uncertainties have unknown bounds. This technique is more robust and simpler to implement than the quaternion one and only needs the information about the sliding mode surface.
The flight tests demonstrate the robustness of an adaptive integral sliding mode. The former ensures a better derivation of the desired input signal in real time, and this ensures a good accuracy in terms of tracking for a desired reference.
Trauma remains a significant public health issue and is the fourth leading cause of death in persons younger than 40 years [1, 2]. Worldwide, about 16,000 people die every day as a result of an injury (5.8 million deaths per year), and the projections for 2020 show that 8.4 million deaths per year are expected [3].Consequently, injury will be the second most common cause of disability adjusted years of life lost within the next 13 years (second only to cardiovascular disease). Undoubtedly, the major burden of injury is increasingly occurring in the developing world as it industrializes, adopts motorized transportation, and remains the major center for armed conflict [4, 5]. Despite advancement in primary care to trauma patients, early resuscitation in the emergency department, surgical interventions, and intensive care monitoring, mortality rate has not improved yet. The higher rate of mortality to trauma patients is usually associated with development of various complications such as sepsis, septic shock, and the development of the multiple organ dysfunction syndrome (MODS) [6, 7]. The outcome of trauma patients is not determined only by trauma but also by the impacts of immune-inflammatory insult. The inflammatory response is crucial for the host defense against infections, but hysterical immune inflammatory responses are generated due to imbalance in the production of inflammatory and anti-inflammatory cytokines which may lead to various complications and consequently unfavorable outcomes [8, 9]. According to the biphasic model of trauma etiology, dysregulations in the production of both inflammatory and anti-inflammatory cytokines primarily lead to the sepsis-associated mortalities and outcomes [10, 11]. Posttraumatic sepsis which may cause hysterical immune inflammatory responses is one of the leading sources of MODS in the ICU. Although there have been many advances in the development of broad and narrow spectrum of antibiotics and thoughtful care, sepsis remains a serious and deadly problem with high mortality rates across the globe. Therefore, prognostic biomarkers to identify high-risk trauma patients in the early stages are immediately needed for early detection and preventive care of sepsis. The management of severely injured and multiple trauma patients who developed sepsis, septic shock, and MODS due to inflammatory insults is challenging for the physician in the ICU. Trauma leads to imbalance in production of pro-inflammatory and anti-inflammatory cytokines which may subsequently lead to the SIRS, sepsis, septic shock, and MODS which are shown in Figure 1.
This figure shows that trauma leads to the imbalanced cytokine production which may subsequently lead to the sepsis, severe sepsis, septic shock, MODS, and at last death. This figure also shows the criteria which are used to define the SIRS sepsis, severe sepsis, septic shock, and MODS.
Systemic inflammatory response syndrome (SIRS) is a term that was developed in an attempt to describe the clinical manifestations that result from the systemic response to injury. The criteria of SIRS are considered as having at least two of the following four clinical parameters abnormal:
Temperature < 36°C or > 38° C
Heart rate > 90 beats/min
Respiratory rate > 20 breaths/min or Paco2 < 32 mm Hg
WBC count >12,000 cells/μL or < 4000 cells/μL, or > 10% immature forms
Sepsis is a common, deadly, and often underappreciated disease process in emergency departments. In the intensive care unit, if patients have SIRS along with documented cultures reports positive is called sepsis. Sepsis results in physiologic alterations that occur at the capillary endothelial level.
Sepsis accompanied by signs of failure of at least one organ. Cardiovascular failure is typically manifested with hypotension, respiratory failure by hypoxemia, renal failure by oliguria, and hematologic failure by coagulopathy.
Severe sepsis with organ hypoperfusion and hypotension that are poorly responsive to initial fluid resuscitation.
Multiple organ failure is a clinical syndrome in which the functionality of several organs fails subsequently or simultaneously (i.e., liver, lungs, kidneys, heart). Multiple organ failure after trauma has a multifactorial etiology, which can be divided in endogenous and exogenous factors [12]. The endogenous factors, such as genetic predisposition, form the basis of the patient’s susceptibility for the development of organ failure. Recent studies have shown that genetic variations (e.g., TNF-α polymorphisms) are strongly associated with the development of organ failure [13].The exogenous factors, such as injury itself (the “first hit” or “trauma load”) and the resuscitation or surgical intervention (the “second hit” or “intervention load”), play a crucial role in the development of organ failure. Organ damage and subsequent organ failure are the result of dysfunctional immune system [11, 14].
Cytokines are low molecular weight polypeptides, and pharmacologically active molecules possess autocrine, paracrine, and juxtracrine effects [15]. These molecules are classified into several classes (i.e., interleukins, interferons, colony-stimulating factors, tumor necrosis factors, transforming growth factors, and chemokines), which are relevant to mediate the humoral and cellular immunity to protect the host against pathogens [16]. Cytokines are produced by a wide variety of lymphoid and nonlymphoid cells in the body, playing an important role in many physiological responses against infections and injury. In addition, cytokines exert important pleiotropic actions as cardinal effectors of injury [17]. They play vital roles in the regulation of host immune response, and distorted expression of cytokines is proven to be involved in development of complications such as sepsis, septic shock, and MODS. Many studies suggested that the genetic background of individuals determines the impacts of immune inflammatory response after trauma which may lead to differential cellular activations of immune cells, leukocyte migrations, and effector functions (Figure 2). Previous research suggests that the variations in the genes encoding cytokines are also involved in the inflammatory responses and also responsible for inter-individual differences in susceptibility to sepsis and in its severity [13, 18, 19]. Therefore, understanding the variations in cytokine genes and associated differences in response to trauma might contribute to the development of new genetically modified diagnostic and therapeutic interventions that may improve outcome in posttraumatic sepsis patients.
The outcome of trauma patients depends on induced inflammatory response due to trauma such as migration of leukocytes, cellular activation, and effecter functions, which may subsequently depend on genetic background of individuals.
Cytokine gene polymorphism, therefore, is advocated as the underlying reason to distinguish individual specific immune responses. The cytokine gene polymorphism studies may be considered as powerful biomarkers for the identification of trauma patients who have higher risk to develop sepsis complications in the ICU [20, 21]. Therefore, understanding the associations between genetic polymorphisms and sepsis or MODS may lead to the better understanding of sepsis. Nowadays the significance of genetic variations [particularly single-nucleotide polymorphisms (SNPs)] as key determinants of inter-individual variations in both inflammatory responses and clinical outcome in trauma patients is advocated [13, 22]. Single-nucleotide polymorphisms are the key factors to regulate the expressional variation of human genes and found to be associated with the disease susceptibility and progression. To understand the importance of cytokine gene polymorphism (CGP) while predicting the occurrence of sepsis, the SNPs in the promoter, coding, and noncoding regions of 13 cytokine genes with 22 loci are commonly used. Single-nucleotide polymorphisms of 13 cytokine genes including interleukin IL-1-α (T/C-889), IL-1-β (-511 C/T, T/C + 3962), IL-1 RA (T/C mspal 1100), IL-4 RA (G/A + 1902), IL-4(T/G-1098, T/C-590, T/C-33), IL-6 (G/C-174, G/A nt560), IL-10 (G/C-1082, C/T-819, C/A-592), IL-12 (C/A-1188), γIFN (+874 A/T), TGF-β1(C/T codon 10, G/C codon 25), TNF α (G/A -308, G/A-238), and IL-2(T/G-330 G/T + 166), to investigate the susceptibility towards sepsis in trauma patients, are commonly used. All the cytokine genes and their polymorphic loci which are commonly used to investigate the genetic basis of susceptibility towards disease are shown in Table 1. Various studies also showed the associations of these SNPs in the development of sepsis and outcomes. The polymorphic loci in the promoter region of TNF-α-308 and TNF-α-238 have been reported by various studies and showed susceptibility and resistance between populations [23, 24]. These two polymorphisms are well recognized and associated with susceptibility for tuberculosis, heart disease, and Graves’ disease [25, 26, 27]. The interleukin 6 is an important cytokine and plays a very important role in the activation of T17 cells. The polymorphisms in the promoter region of IL-6 (−174 G/C) and structural region (+560) are well characterized in various diseases. However, the polymorphism in the promoter regions (−174G/C) showed significant association with celiac disease, bowel syndrome, cancer, and autoimmunity [28, 29, 30, 31]. Interestingly, the polymorphism in the promoter region of IL-6 (−174 G/C) influenced the immunopathogenesis of sepsis and associated with outcomes in European population of trauma [32, 33]. We have also reported the association of IL-6 (−174 G/C) polymorphism and susceptibility of sepsis in the Indian trauma patients [34]. IL-10 is an important anti-inflammatory cytokine and plays a very crucial role in the inflammation, autoimmunity, and tolerance. Many studies suggested that elevated level of IL-10 activates the transcription factor Fox P3 which may subsequently lead to the production T regulatory cells. Polymorphism in the promoter regions of IL-10 gene −1082(G/A), −819(C/T), and − 592(C/A) is well established and showed significant association with various infectious diseases, autoimmunity, cancer D, and diabetic retinopathy [35, 36, 37]. These IL-10 promoters, −1082(G/A), −819(C/T), and − 592(C/A) polymorphisms, are associated with resistance to sepsis in the Caucasian population [38, 39]. Interleukin (IL-1) gene complex consists of IL-1α, IL-1β, IL-1R, and IL-RA genes with five potent polymorphic loci in the structural and promoter regions [40]. These polymorphic loci are associated with susceptibility for sepsis in trauma patients of the Chinese population [41, 42] and also associated with other diseases, such as cancer and autoimmunity [43, 44]. In our study, we have reported the changes in alleles and genotype frequency at the promoter region of IL-1β (−511) gene. We have also reported the significant association of this polymorphism with susceptibility for sepsis in Indian trauma patients. The recently published work by Gupta et al., 2016, showed that polymorphisms in the structural and promoter regions of TNF-α, IL-β, IL-6, and IL-10 are significantly associated with susceptibility to sepsis and outcomes in trauma patients [34]
Twenty-two single-nucleotide polymorphism in 13 cytokine genes including structural and coding regions.
This figure shows the cytokine genes and its polymorphic loci present in the structural and promoter regions which are significantly involved in susceptibility for sepsis, septic shock, and death.
The purpose of this chapter is to bring together currently available information of cytokine gene polymorphisms in pro-inflammatory and anti-inflammatory cytokine genes in the development of various complications such as sepsis, septic shock, and MODS in trauma patients. Specific emphasis is placed on the polymorphism of those cytokines which potentially contributed to the development of these complications and correlates with unfavorable outcomes.
This work was funded through the Indian Council of Medical Research (ICMR), New Delhi. The author is thankful to the University Grant Commission (UGC), New Delhi, India, for fellowship assistance. The excellent scientific assistance of Dr. Vinay, Dr. Amit Gupta, and Dr. Arul Selvi is acknowledged.
The authors have no conflicts of interest.
This is a brief overview of the main steps involved in publishing with IntechOpen Compacts, Monographs and Edited Books. Once you submit your proposal you will be appointed a Author Service Manager who will be your single point of contact and lead you through all the described steps below.
",metaTitle:"Publishing Process Steps and Descriptions",metaDescription:"This is a brief overview of the main steps involved in publishing with InTechOpen Compacts, Monographs and Edited Books. Once you submit your proposal you will be appointed a Publishing Process Manager who will be your single point of contact and lead you through all the described steps below.",metaKeywords:null,canonicalURL:"page/publishing-process-steps",contentRaw:'[{"type":"htmlEditorComponent","content":"1. SEND YOUR PROPOSAL
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\n\nPlease complete the publishing proposal form. The completed form should serve as an overview of your future Compacts, Monograph or Edited Book. Once submitted, your publishing proposal will be sent for evaluation, and a notice of acceptance or rejection will be sent within 10 to 30 working days from the date of submission.
\n\n2. SUBMIT YOUR MANUSCRIPT
\n\nAfter approval, you will proceed in submitting your full-length manuscript. 50-130 pages for compacts, 130-500 for Monographs & Edited Books.Your full-length manuscript must follow IntechOpen's Author Guidelines and comply with our publishing rules. Once the manuscript is submitted, but before it is forwarded for peer review, it will be screened for plagiarism.
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Segmentation is a section of image processing for the separation or segregation of information from the required target region of the image. There are different techniques used for segmentation of pixels of interest from the image. Active contour is one of the active models in segmentation techniques, which makes use of the energy constraints and forces in the image for separation of region of interest. Active contour defines a separate boundary or curvature for the regions of target object for segmentation. The contour depends on various constraints based on which they are classified into different types such as gradient vector flow, balloon and geometric models. Active contour models are used in various image processing applications specifically in medical image processing. In medical imaging, active contours are used in segmentation of regions from different medical images such as brain CT images, MRI images of different organs, cardiac images and different images of regions in the human body. Active contours can also be used in motion tracking and stereo tracking. Thus, the active contour segmentation is used for the separation of pixels of interest for different image processing.",book:{id:"6692",slug:"medical-and-biological-image-analysis",title:"Medical and Biological Image Analysis",fullTitle:"Medical and Biological Image Analysis"},signatures:"R.J. Hemalatha, T.R. Thamizhvani, A. Josephin Arockia Dhivya,\nJosline Elsa Joseph, Bincy Babu and R. Chandrasekaran",authors:[{id:"238868",title:"Prof.",name:"Hemalatha",middleName:null,surname:"R.J",slug:"hemalatha-r.j",fullName:"Hemalatha R.J"},{id:"242385",title:"Dr.",name:"Chandrasekaran",middleName:null,surname:"R",slug:"chandrasekaran-r",fullName:"Chandrasekaran R"},{id:"242386",title:"Ms.",name:"Thamizhvani",middleName:null,surname:"T.R",slug:"thamizhvani-t.r",fullName:"Thamizhvani T.R"},{id:"242388",title:"Dr.",name:"Josephin Arockia Dhivya",middleName:null,surname:"A",slug:"josephin-arockia-dhivya-a",fullName:"Josephin Arockia Dhivya A"},{id:"242389",title:"Ms.",name:"Josline Elsa",middleName:null,surname:"Joseph",slug:"josline-elsa-joseph",fullName:"Josline Elsa Joseph"},{id:"242390",title:"Ms.",name:"Bincy",middleName:null,surname:"Babu",slug:"bincy-babu",fullName:"Bincy Babu"}]},{id:"67331",doi:"10.5772/intechopen.84360",title:"Research in Medical Imaging Using Image Processing Techniques",slug:"research-in-medical-imaging-using-image-processing-techniques",totalDownloads:4345,totalCrossrefCites:5,totalDimensionsCites:9,abstract:"Medical imaging is the procedure used to attain images of the body parts for medical uses in order to identify or study diseases. There are millions of imaging procedures done every week worldwide. Medical imaging is developing rapidly due to developments in image processing techniques including image recognition, analysis, and enhancement. Image processing increases the percentage and amount of detected tissues. This chapter presents the application of both simple and sophisticated image analysis techniques in the medical imaging field. This chapter also summarizes how to exemplify image interpretation challenges using different image processing algorithms such as k-means, ROI-based segmentation, and watershed techniques.",book:{id:"8125",slug:"medical-imaging-principles-and-applications",title:"Medical Imaging",fullTitle:"Medical Imaging - Principles and Applications"},signatures:"Yousif Mohamed Y. 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This provides a new idea for revealing the underlining mechanisms of neuropathic pain and improving the clinical treatment concepts. In this chapter, we summarized the recent studies of fMRI in neuropathic pain so that readers can better understand the research status and future research directions.",book:{id:"8125",slug:"medical-imaging-principles-and-applications",title:"Medical Imaging",fullTitle:"Medical Imaging - Principles and Applications"},signatures:"Zhi Dou and Liqiang Yang",authors:[{id:"302075",title:"Ph.D.",name:"Zhi",middleName:null,surname:"Dou",slug:"zhi-dou",fullName:"Zhi Dou"},{id:"310181",title:"Dr.",name:"Liqiang",middleName:null,surname:"Yang",slug:"liqiang-yang",fullName:"Liqiang Yang"}]},{id:"68142",doi:"10.5772/intechopen.88004",title:"Elastometry Indices of Unchanged Liver in Healthy Children",slug:"elastometry-indices-of-unchanged-liver-in-healthy-children",totalDownloads:662,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"Two hundred healthy children aged 3–18 years were included in the study to determine liver stiffness indices by means of shear wave elastometry. The difference is significant when we compared shear wave velocity in children aged 3–6 years, on the one hand, and in children aged 7–18 years, on the other (p = 0.001). Liver stiffness indices in boys and girls were not different. As a result, liver stiffness indices in children in various age groups have been obtained, which can be recommended as normal ones for pediatric patients.",book:{id:"8691",slug:"ultrasound-elastography",title:"Ultrasound Elastography",fullTitle:"Ultrasound Elastography"},signatures:"Mikhail Pykov, Natalia Kuzmina, Nikolay Rostovtsev and Alexander Kinzersky",authors:null},{id:"68259",doi:"10.5772/intechopen.88183",title:"2D Shear Wave Elastography for Liver Fibrosis Evaluation",slug:"2d-shear-wave-elastography-for-liver-fibrosis-evaluation",totalDownloads:1201,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"2D shear wave elastography is a technique embedded in ultrasound machines which allows the interrogation of the tissue by acoustic radiation force impulses induced into the tissues by focused ultrasonic beams and captures the propagation of resulting shear waves in real time. Elasticity is displayed using a color-coded image superimposed on a B-mode image, and at the same time, a quantitative estimation of liver stiffness (LS) can be performed in a certain region of interest (ROI). The published data showed a real value of this method for liver stiffness estimation in patients with chronic hepatitis. It has the following advantages: it is integrated into standard ultrasound systems; it is a real-time elastographic method; and it is also feasible in patients with ascites and with large and adjustable size of the ROI that will be evaluated.",book:{id:"8691",slug:"ultrasound-elastography",title:"Ultrasound Elastography",fullTitle:"Ultrasound Elastography"},signatures:"Alina Popescu, Roxana Şirli and Ioan Sporea",authors:null}],mostDownloadedChaptersLast30Days:[{id:"67331",title:"Research in Medical Imaging Using Image Processing Techniques",slug:"research-in-medical-imaging-using-image-processing-techniques",totalDownloads:4342,totalCrossrefCites:5,totalDimensionsCites:9,abstract:"Medical imaging is the procedure used to attain images of the body parts for medical uses in order to identify or study diseases. There are millions of imaging procedures done every week worldwide. 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The features of some characteristic detector systems with the relative electronics and the data acquisition system (DAQ) are presented. Those detectors are related with the medical imaging sensor systems. The characteristics of the medical imaging process of the X-ray and nuclear imaging with SPECT, PET and the combination of PET-CT are presented. The computed X-ray tomography, called CT, and the nuclear medicine tomography are presented, implementing the most of the previous parts, as they are defined in PET and SPECT imaging plus the combination of PET with CT the PET-CT.",book:{id:"8125",slug:"medical-imaging-principles-and-applications",title:"Medical Imaging",fullTitle:"Medical Imaging - Principles and Applications"},signatures:"Evangelos Gazis",authors:[{id:"281707",title:"Prof.",name:"Evangelos",middleName:null,surname:"Gazis",slug:"evangelos-gazis",fullName:"Evangelos Gazis"}]},{id:"68830",title:"PET-CT Principles and Applications in Lung Cancer Management",slug:"pet-ct-principles-and-applications-in-lung-cancer-management",totalDownloads:1115,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"Lung cancer is the most common malignant cancer throughout the world; the positron emission tomography/computed tomography (PET-CT) combines both the metabolism information from PET and anatomy details from CT, which is the state of the art. This manuscript introduced the PET-CT and applications in lung cancer diagnosing, staging, and treatment. Several aspects including clinical features, classification, grading and pathology of the lung cancer, principles of PET-CT, and evaluation of diagnosing and treatment had been covered. Detailed demonstration of each cancer subtype, staging criteria, and classification was described. The content will benefit the clinical doctors as well as radiologists.",book:{id:"8125",slug:"medical-imaging-principles-and-applications",title:"Medical Imaging",fullTitle:"Medical Imaging - Principles and Applications"},signatures:"Long Chen, Hua Sun and Yunchao Huang",authors:[{id:"278386",title:"Ph.D.",name:"Long",middleName:null,surname:"Chen",slug:"long-chen",fullName:"Long Chen"},{id:"280160",title:"Prof.",name:"Yunchao",middleName:null,surname:"Huang",slug:"yunchao-huang",fullName:"Yunchao Huang"},{id:"280161",title:"Prof.",name:"Hua",middleName:null,surname:"Sun",slug:"hua-sun",fullName:"Hua Sun"}]},{id:"64352",title:"Endoscopic Dacryocystorhinostomy",slug:"endoscopic-dacryocystorhinostomy-1",totalDownloads:5920,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"Epiphora, or abnormal tearing, occurs because of the blockage in the lacrimal drainage system, which impairs normal tearing channeling into the nose. It is essential that with proper history and examination including syringing and probing, a correct diagnosis is made. Syringing and probing are performed only in congenital and acquired nasolacrimal duct obstruction (NLDO). Dacryocystorhinostomy (DCR) is a procedure performed for the treatment of tearing (epiphora) due to blockage of the nasolacrimal drainage system. Endoscopic dacryocystorhinostomy (E-DCR) using telescopes has gained a lot of momentum among otolaryngologists, since the outcomes are comparable to the external approach. Advances in surgical technique and a better understanding of the anatomy have resulted in improvements in outcomes. The anatomy of the lacrimal system will be discussed in detail including the surgical indications and techniques of DCR. The advantages, results, and complications of surgery will be highlighted.",book:{id:"7255",slug:"endoscopy-novel-techniques-and-recent-advancements",title:"Endoscopy",fullTitle:"Endoscopy - Novel Techniques and Recent Advancements"},signatures:"Balwant Singh Gendeh",authors:[{id:"67669",title:null,name:"Balwant Singh",middleName:null,surname:"Gendeh",slug:"balwant-singh-gendeh",fullName:"Balwant Singh Gendeh"}]},{id:"59741",title:"Active Contour Based Segmentation Techniques for Medical Image Analysis",slug:"active-contour-based-segmentation-techniques-for-medical-image-analysis",totalDownloads:3470,totalCrossrefCites:25,totalDimensionsCites:43,abstract:"Image processing is a technique which is used to derive information from the images. Segmentation is a section of image processing for the separation or segregation of information from the required target region of the image. There are different techniques used for segmentation of pixels of interest from the image. Active contour is one of the active models in segmentation techniques, which makes use of the energy constraints and forces in the image for separation of region of interest. Active contour defines a separate boundary or curvature for the regions of target object for segmentation. The contour depends on various constraints based on which they are classified into different types such as gradient vector flow, balloon and geometric models. Active contour models are used in various image processing applications specifically in medical image processing. In medical imaging, active contours are used in segmentation of regions from different medical images such as brain CT images, MRI images of different organs, cardiac images and different images of regions in the human body. Active contours can also be used in motion tracking and stereo tracking. 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He is the author of several scientific articles, book chapters, and books.",institutionString:"University of Hassan II Casablanca",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"7",totalChapterViews:"0",totalEditedBooks:"2",institution:{name:"University of Hassan II Casablanca",institutionURL:null,country:{name:"Morocco"}}},equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7060",title:"Gingival Disease",subtitle:"A Professional Approach for Treatment and Prevention",coverURL:"https://cdn.intechopen.com/books/images_new/7060.jpg",slug:"gingival-disease-a-professional-approach-for-treatment-and-prevention",publishedDate:"October 23rd 2019",editedByType:"Edited by",bookSignature:"Alaa Eddin Omar Al Ostwani",hash:"b81d39988cba3a3cf746c1616912cf41",volumeInSeries:4,fullTitle:"Gingival Disease - A Professional Approach for Treatment and Prevention",editors:[{id:"240870",title:"Ph.D.",name:"Alaa Eddin Omar",middleName:null,surname:"Al Ostwani",slug:"alaa-eddin-omar-al-ostwani",fullName:"Alaa Eddin Omar Al Ostwani",profilePictureURL:"https://mts.intechopen.com/storage/users/240870/images/system/240870.jpeg",institutionString:"International University for Science and Technology.",institution:{name:"Islamic University of Science and Technology",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7572",title:"Trauma in Dentistry",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7572.jpg",slug:"trauma-in-dentistry",publishedDate:"July 3rd 2019",editedByType:"Edited by",bookSignature:"Serdar Gözler",hash:"7cb94732cfb315f8d1e70ebf500eb8a9",volumeInSeries:3,fullTitle:"Trauma in Dentistry",editors:[{id:"204606",title:"Dr.",name:"Serdar",middleName:null,surname:"Gözler",slug:"serdar-gozler",fullName:"Serdar Gözler",profilePictureURL:"https://mts.intechopen.com/storage/users/204606/images/system/204606.jpeg",institutionString:"Istanbul Aydin University",institution:{name:"Istanbul Aydın University",institutionURL:null,country:{name:"Turkey"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7139",title:"Current Approaches in Orthodontics",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7139.jpg",slug:"current-approaches-in-orthodontics",publishedDate:"April 10th 2019",editedByType:"Edited by",bookSignature:"Belma Işık Aslan and Fatma Deniz Uzuner",hash:"2c77384eeb748cf05a898d65b9dcb48a",volumeInSeries:2,fullTitle:"Current Approaches in Orthodontics",editors:[{id:"42847",title:"Dr.",name:"Belma",middleName:null,surname:"Işik Aslan",slug:"belma-isik-aslan",fullName:"Belma Işik Aslan",profilePictureURL:"https://mts.intechopen.com/storage/users/42847/images/system/42847.jpg",institutionString:"Gazi University Dentistry Faculty Department of Orthodontics",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"6668",title:"Dental Caries",subtitle:"Diagnosis, Prevention and Management",coverURL:"https://cdn.intechopen.com/books/images_new/6668.jpg",slug:"dental-caries-diagnosis-prevention-and-management",publishedDate:"September 19th 2018",editedByType:"Edited by",bookSignature:"Zühre Akarslan",hash:"b0f7667770a391f772726c3013c1b9ba",volumeInSeries:1,fullTitle:"Dental Caries - Diagnosis, Prevention and Management",editors:[{id:"171887",title:"Prof.",name:"Zühre",middleName:null,surname:"Akarslan",slug:"zuhre-akarslan",fullName:"Zühre Akarslan",profilePictureURL:"https://mts.intechopen.com/storage/users/171887/images/system/171887.jpg",institutionString:"Gazi University",institution:{name:"Gazi University",institutionURL:null,country:{name:"Turkey"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Prosthodontics and Implant Dentistry",value:2,count:2},{group:"subseries",caption:"Oral Health",value:1,count:6}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:2},{group:"publicationYear",caption:"2020",value:2020,count:2},{group:"publicationYear",caption:"2019",value:2019,count:3},{group:"publicationYear",caption:"2018",value:2018,count:1}],authors:{paginationCount:229,paginationItems:[{id:"318170",title:"Dr.",name:"Aneesa",middleName:null,surname:"Moolla",slug:"aneesa-moolla",fullName:"Aneesa Moolla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/318170/images/system/318170.png",biography:"Dr. Aneesa Moolla has extensive experience in the diverse fields of health care having previously worked in dental private practice, at the Red Cross Flying Doctors association, and in healthcare corporate settings. She is now a lecturer at the University of Witwatersrand, South Africa, and a principal researcher at the Health Economics and Epidemiology Research Office (HE2RO), South Africa. Dr. Moolla holds a Ph.D. in Psychology with her research being focused on mental health and resilience. In her professional work capacity, her research has further expanded into the fields of early childhood development, mental health, the HIV and TB care cascades, as well as COVID. She is also a UNESCO-trained International Bioethics Facilitator.",institutionString:"University of the Witwatersrand",institution:{name:"University of the Witwatersrand",country:{name:"South Africa"}}},{id:"419588",title:"Ph.D.",name:"Sergio",middleName:"Alexandre",surname:"Gehrke",slug:"sergio-gehrke",fullName:"Sergio Gehrke",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038WgMKQA0/Profile_Picture_2022-06-02T11:44:20.jpg",biography:"Dr. Sergio Alexandre Gehrke is a doctorate holder in two fields. The first is a Ph.D. in Cellular and Molecular Biology from the Pontificia Catholic University, Porto Alegre, Brazil, in 2010 and the other is an International Ph.D. in Bioengineering from the Universidad Miguel Hernandez, Elche/Alicante, Spain, obtained in 2020. In 2018, he completed a postdoctoral fellowship in Materials Engineering in the NUCLEMAT of the Pontificia Catholic University, Porto Alegre, Brazil. He is currently the Director of the Postgraduate Program in Implantology of the Bioface/UCAM/PgO (Montevideo, Uruguay), Director of the Cathedra of Biotechnology of the Catholic University of Murcia (Murcia, Spain), an Extraordinary Full Professor of the Catholic University of Murcia (Murcia, Spain) as well as the Director of the private center of research Biotecnos – Technology and Science (Montevideo, Uruguay). Applied biomaterials, cellular and molecular biology, and dental implants are among his research interests. He has published several original papers in renowned journals. In addition, he is also a Collaborating Professor in several Postgraduate programs at different universities all over the world.",institutionString:null,institution:{name:"Universidad Católica San Antonio de Murcia",country:{name:"Spain"}}},{id:"342152",title:"Dr.",name:"Santo",middleName:null,surname:"Grace Umesh",slug:"santo-grace-umesh",fullName:"Santo Grace Umesh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/342152/images/16311_n.jpg",biography:null,institutionString:null,institution:{name:"SRM Dental College",country:{name:"India"}}},{id:"333647",title:"Dr.",name:"Shreya",middleName:null,surname:"Kishore",slug:"shreya-kishore",fullName:"Shreya Kishore",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333647/images/14701_n.jpg",biography:"Dr. Shreya Kishore completed her Bachelor in Dental Surgery in Chettinad Dental College and Research Institute, Chennai, and her Master of Dental Surgery (Orthodontics) in Saveetha Dental College, Chennai. She is also Invisalign certified. She’s working as a Senior Lecturer in the Department of Orthodontics, SRM Dental College since November 2019. She is actively involved in teaching orthodontics to the undergraduates and the postgraduates. Her clinical research topics include new orthodontic brackets, fixed appliances and TADs. She’s published 4 articles in well renowned indexed journals and has a published patency of her own. Her private practice is currently limited to orthodontics and works as a consultant in various clinics.",institutionString:null,institution:{name:"SRM Dental College",country:{name:"India"}}},{id:"323731",title:"Prof.",name:"Deepak M.",middleName:"Macchindra",surname:"Vikhe",slug:"deepak-m.-vikhe",fullName:"Deepak M. Vikhe",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/323731/images/13613_n.jpg",biography:"Dr Deepak M.Vikhe .\n\n\t\n\tDr Deepak M.Vikhe , completed his Masters & PhD in Prosthodontics from Rural Dental College, Loni securing third rank in the Pravara Institute of Medical Sciences Deemed University. He was awarded Dr.G.C.DAS Memorial Award for Research on Implants at 39th IPS conference Dubai (U A E).He has two patents under his name. He has received Dr.Saraswati medal award for best research for implant study in 2017.He has received Fully funded scholarship to Spain ,university of Santiago de Compostela. He has completed fellowship in Implantlogy from Noble Biocare. \nHe has attended various conferences and CDE programmes and has national publications to his credit. His field of interest is in Implant supported prosthesis. Presently he is working as a associate professor in the Dept of Prosthodontics, Rural Dental College, Loni and maintains a successful private practice specialising in Implantology at Rahata.\n\nEmail: drdeepak_mvikhe@yahoo.com..................",institutionString:null,institution:{name:"Pravara Institute of Medical Sciences",country:{name:"India"}}},{id:"204110",title:"Dr.",name:"Ahmed A.",middleName:null,surname:"Madfa",slug:"ahmed-a.-madfa",fullName:"Ahmed A. Madfa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204110/images/system/204110.jpg",biography:"Dr. Madfa is currently Associate Professor of Endodontics at Thamar University and a visiting lecturer at Sana'a University and University of Sciences and Technology. He has more than 6 years of experience in teaching. His research interests include root canal morphology, functionally graded concept, dental biomaterials, epidemiology and dental education, biomimetic restoration, finite element analysis and endodontic regeneration. Dr. Madfa has numerous international publications, full articles, two patents, a book and a book chapter. Furthermore, he won 14 international scientific awards. Furthermore, he is involved in many academic activities ranging from editorial board member, reviewer for many international journals and postgraduate students' supervisor. Besides, I deliver many courses and training workshops at various scientific events. Dr. Madfa also regularly attends international conferences and holds administrative positions (Deputy Dean of the Faculty for Students’ & Academic Affairs and Deputy Head of Research Unit).",institutionString:"Thamar University",institution:null},{id:"210472",title:"Dr.",name:"Nermin",middleName:"Mohammed Ahmed",surname:"Yussif",slug:"nermin-yussif",fullName:"Nermin Yussif",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/210472/images/system/210472.jpg",biography:"Dr. Nermin Mohammed Ahmed Yussif is working at the Faculty of dentistry, University for October university for modern sciences and arts (MSA). Her areas of expertise include: periodontology, dental laserology, oral implantology, periodontal plastic surgeries, oral mesotherapy, nutrition, dental pharmacology. She is an editor and reviewer in numerous international journals.",institutionString:"MSA University",institution:null},{id:"204606",title:"Dr.",name:"Serdar",middleName:null,surname:"Gözler",slug:"serdar-gozler",fullName:"Serdar Gözler",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204606/images/system/204606.jpeg",biography:"Dr. Serdar Gözler has completed his undergraduate studies at the Marmara University Faculty of Dentistry in 1978, followed by an assistantship in the Prosthesis Department of Dicle University Faculty of Dentistry. Starting his PhD work on non-resilient overdentures with Assoc. Prof. Hüsnü Yavuzyılmaz, he continued his studies with Prof. Dr. Gürbüz Öztürk of Istanbul University Faculty of Dentistry Department of Prosthodontics, this time on Gnatology. He attended training programs on occlusion, neurology, neurophysiology, EMG, radiology and biostatistics. In 1982, he presented his PhD thesis \\Gerber and Lauritzen Occlusion Analysis Techniques: Diagnosis Values,\\ at Istanbul University School of Dentistry, Department of Prosthodontics. As he was also working with Prof. Senih Çalıkkocaoğlu on The Physiology of Chewing at the same time, Gözler has written a chapter in Çalıkkocaoğlu\\'s book \\Complete Prostheses\\ entitled \\The Place of Neuromuscular Mechanism in Prosthetic Dentistry.\\ The book was published five times since by the Istanbul University Publications. Having presented in various conferences about occlusion analysis until 1998, Dr. Gözler has also decided to use the T-Scan II occlusion analysis method. Having been personally trained by Dr. Robert Kerstein on this method, Dr. Gözler has been lecturing on the T-Scan Occlusion Analysis Method in conferences both in Turkey and abroad. Dr. Gözler has various articles and presentations on Digital Occlusion Analysis methods. He is now Head of the TMD Clinic at Prosthodontic Department of Faculty of Dentistry , Istanbul Aydın University , Turkey.",institutionString:"Istanbul Aydin University",institution:{name:"Istanbul Aydın University",country:{name:"Turkey"}}},{id:"240870",title:"Ph.D.",name:"Alaa Eddin Omar",middleName:null,surname:"Al Ostwani",slug:"alaa-eddin-omar-al-ostwani",fullName:"Alaa Eddin Omar Al Ostwani",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/240870/images/system/240870.jpeg",biography:"Dr. Al Ostwani Alaa Eddin Omar received his Master in dentistry from Damascus University in 2010, and his Ph.D. in Pediatric Dentistry from Damascus University in 2014. Dr. Al Ostwani is an assistant professor and faculty member at IUST University since 2014. \nDuring his academic experience, he has received several awards including the scientific research award from the Union of Arab Universities, the Syrian gold medal and the international gold medal for invention and creativity. Dr. Al Ostwani is a Member of the International Association of Dental Traumatology and the Syrian Society for Research and Preventive Dentistry since 2017. He is also a Member of the Reviewer Board of International Journal of Dental Medicine (IJDM), and the Indian Journal of Conservative and Endodontics since 2016.",institutionString:"International University for Science and Technology.",institution:{name:"Islamic University of Science and Technology",country:{name:"India"}}},{id:"42847",title:"Dr.",name:"Belma",middleName:null,surname:"Işik Aslan",slug:"belma-isik-aslan",fullName:"Belma Işik Aslan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/42847/images/system/42847.jpg",biography:"Dr. Belma IşIk Aslan was born in 1976 in Ankara-TURKEY. After graduating from TED Ankara College in 1994, she attended to Gazi University, Faculty of Dentistry in Ankara. She completed her PhD in orthodontic education at Gazi University between 1999-2005. Dr. Işık Aslan stayed at the Providence Hospital Craniofacial Institude and Reconstructive Surgery in Michigan, USA for three months as an observer. She worked as a specialist doctor at Gazi University, Dentistry Faculty, Department of Orthodontics between 2005-2014. She was appointed as associate professor in January, 2014 and as professor in 2021. Dr. Işık Aslan still works as an instructor at the same faculty. She has published a total of 35 articles, 10 book chapters, 39 conference proceedings both internationally and nationally. Also she was the academic editor of the international book 'Current Advances in Orthodontics'. She is a member of the Turkish Orthodontic Society and Turkish Cleft Lip and Palate Society. She is married and has 2 children. Her knowledge of English is at an advanced level.",institutionString:"Gazi University Dentistry Faculty Department of Orthodontics",institution:null},{id:"178412",title:"Associate Prof.",name:"Guhan",middleName:null,surname:"Dergin",slug:"guhan-dergin",fullName:"Guhan Dergin",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178412/images/6954_n.jpg",biography:"Assoc. Prof. Dr. Gühan Dergin was born in 1973 in Izmit. He graduated from Marmara University Faculty of Dentistry in 1999. He completed his specialty of OMFS surgery in Marmara University Faculty of Dentistry and obtained his PhD degree in 2006. In 2005, he was invited as a visiting doctor in the Oral and Maxillofacial Surgery Department of the University of North Carolina, USA, where he went on a scholarship. Dr. Dergin still continues his academic career as an associate professor in Marmara University Faculty of Dentistry. He has many articles in international and national scientific journals and chapters in books.",institutionString:null,institution:{name:"Marmara University",country:{name:"Turkey"}}},{id:"178414",title:"Prof.",name:"Yusuf",middleName:null,surname:"Emes",slug:"yusuf-emes",fullName:"Yusuf Emes",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178414/images/6953_n.jpg",biography:"Born in Istanbul in 1974, Dr. Emes graduated from Istanbul University Faculty of Dentistry in 1997 and completed his PhD degree in Istanbul University faculty of Dentistry Department of Oral and Maxillofacial Surgery in 2005. He has papers published in international and national scientific journals, including research articles on implantology, oroantral fistulas, odontogenic cysts, and temporomandibular disorders. Dr. Emes is currently working as a full-time academic staff in Istanbul University faculty of Dentistry Department of Oral and Maxillofacial Surgery.",institutionString:null,institution:{name:"Istanbul University",country:{name:"Turkey"}}},{id:"192229",title:"Ph.D.",name:"Ana Luiza",middleName:null,surname:"De Carvalho Felippini",slug:"ana-luiza-de-carvalho-felippini",fullName:"Ana Luiza De Carvalho Felippini",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192229/images/system/192229.jpg",biography:null,institutionString:"University of São Paulo",institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"256851",title:"Prof.",name:"Ayşe",middleName:null,surname:"Gülşen",slug:"ayse-gulsen",fullName:"Ayşe Gülşen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/256851/images/9696_n.jpg",biography:"Dr. Ayşe Gülşen graduated in 1990 from Faculty of Dentistry, University of Ankara and did a postgraduate program at University of Gazi. \nShe worked as an observer and research assistant in Craniofacial Surgery Departments in New York, Providence Hospital in Michigan and Chang Gung Memorial Hospital in Taiwan. \nShe works as Craniofacial Orthodontist in Department of Aesthetic, Plastic and Reconstructive Surgery, Faculty of Medicine, University of Gazi, Ankara Turkey since 2004.",institutionString:"Univeristy of Gazi",institution:null},{id:"255366",title:"Prof.",name:"Tosun",middleName:null,surname:"Tosun",slug:"tosun-tosun",fullName:"Tosun Tosun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255366/images/7347_n.jpg",biography:"Graduated at the Faculty of Dentistry, University of Istanbul, Turkey in 1989;\nVisitor Assistant at the University of Padua, Italy and Branemark Osseointegration Center of Treviso, Italy between 1993-94;\nPhD thesis on oral implantology in University of Istanbul and was awarded the academic title “Dr.med.dent.”, 1997;\nHe was awarded the academic title “Doç.Dr.” (Associated Professor) in 2003;\nProficiency in Botulinum Toxin Applications, Reading-UK in 2009;\nMastership, RWTH Certificate in Laser Therapy in Dentistry, AALZ-Aachen University, Germany 2009-11;\nMaster of Science (MSc) in Laser Dentistry, University of Genoa, Italy 2013-14.\n\nDr.Tosun worked as Research Assistant in the Department of Oral Implantology, Faculty of Dentistry, University of Istanbul between 1990-2002. \nHe worked part-time as Consultant surgeon in Harvard Medical International Hospitals and John Hopkins Medicine, Istanbul between years 2007-09.\u2028He was contract Professor in the Department of Surgical and Diagnostic Sciences (DI.S.C.), Medical School, University of Genova, Italy between years 2011-16. \nSince 2015 he is visiting Professor at Medical School, University of Plovdiv, Bulgaria. \nCurrently he is Associated Prof.Dr. at the Dental School, Oral Surgery Dept., Istanbul Aydin University and since 2003 he works in his own private clinic in Istanbul, Turkey.\u2028\nDr.Tosun is reviewer in journal ‘Laser in Medical Sciences’, reviewer in journal ‘Folia Medica\\', a Fellow of the International Team for Implantology, Clinical Lecturer of DGZI German Association of Oral Implantology, Expert Lecturer of Laser&Health Academy, Country Representative of World Federation for Laser Dentistry, member of European Federation of Periodontology, member of Academy of Laser Dentistry. Dr.Tosun presents papers in international and national congresses and has scientific publications in international and national journals. He speaks english, spanish, italian and french.",institutionString:null,institution:{name:"Istanbul Aydın University",country:{name:"Turkey"}}},{id:"171887",title:"Prof.",name:"Zühre",middleName:null,surname:"Akarslan",slug:"zuhre-akarslan",fullName:"Zühre Akarslan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/171887/images/system/171887.jpg",biography:"Zühre Akarslan was born in 1977 in Cyprus. She graduated from Gazi University Faculty of Dentistry, Ankara, Turkey in 2000. \r\nLater she received her Ph.D. degree from the Oral Diagnosis and Radiology Department; which was recently renamed as Oral and Dentomaxillofacial Radiology, from the same university. \r\nShe is working as a full-time Associate Professor and is a lecturer and an academic researcher. \r\nHer expertise areas are dental caries, cancer, dental fear and anxiety, gag reflex in dentistry, oral medicine, and dentomaxillofacial radiology.",institutionString:"Gazi University",institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"256417",title:"Associate Prof.",name:"Sanaz",middleName:null,surname:"Sadry",slug:"sanaz-sadry",fullName:"Sanaz Sadry",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/256417/images/8106_n.jpg",biography:null,institutionString:null,institution:null},{id:"272237",title:"Dr.",name:"Pinar",middleName:"Kiymet",surname:"Karataban",slug:"pinar-karataban",fullName:"Pinar Karataban",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/272237/images/8911_n.png",biography:"Assist.Prof.Dr.Pınar Kıymet Karataban, DDS PhD \n\nDr.Pınar Kıymet Karataban was born in Istanbul in 1975. After her graduation from Marmara University Faculty of Dentistry in 1998 she started her PhD in Paediatric Dentistry focused on children with special needs; mainly children with Cerebral Palsy. She finished her pHD thesis entitled \\'Investigation of occlusion via cast analysis and evaluation of dental caries prevalance, periodontal status and muscle dysfunctions in children with cerebral palsy” in 2008. She got her Assist. Proffessor degree in Istanbul Aydın University Paediatric Dentistry Department in 2015-2018. ın 2019 she started her new career in Bahcesehir University, Istanbul as Head of Department of Pediatric Dentistry. In 2020 she was accepted to BAU International University, Batumi as Professor of Pediatric Dentistry. She’s a lecturer in the same university meanwhile working part-time in private practice in Ege Dental Studio (https://www.egedisklinigi.com/) a multidisciplinary dental clinic in Istanbul. Her main interests are paleodontology, ancient and contemporary dentistry, oral microbiology, cerebral palsy and special care dentistry. She has national and international publications, scientific reports and is a member of IAPO (International Association for Paleodontology), IADH (International Association of Disability and Oral Health) and EAPD (European Association of Pediatric Dentistry).",institutionString:null,institution:null},{id:"202198",title:"Dr.",name:"Buket",middleName:null,surname:"Aybar",slug:"buket-aybar",fullName:"Buket Aybar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202198/images/6955_n.jpg",biography:"Buket Aybar, DDS, PhD, was born in 1971. She graduated from Istanbul University, Faculty of Dentistry, in 1992 and completed her PhD degree on Oral and Maxillofacial Surgery in Istanbul University in 1997.\nDr. Aybar is currently a full-time professor in Istanbul University, Faculty of Dentistry Department of Oral and Maxillofacial Surgery. She has teaching responsibilities in graduate and postgraduate programs. Her clinical practice includes mainly dentoalveolar surgery.\nHer topics of interest are biomaterials science and cell culture studies. She has many articles in international and national scientific journals and chapters in books; she also has participated in several scientific projects supported by Istanbul University Research fund.",institutionString:null,institution:null},{id:"260116",title:"Dr.",name:"Mehmet",middleName:null,surname:"Yaltirik",slug:"mehmet-yaltirik",fullName:"Mehmet Yaltirik",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/260116/images/7413_n.jpg",biography:"Birth Date 25.09.1965\r\nBirth Place Adana- Turkey\r\nSex Male\r\nMarrial Status Bachelor\r\nDriving License Acquired\r\nMother Tongue Turkish\r\n\r\nAddress:\r\nWork:University of Istanbul,Faculty of Dentistry, Department of Oral Surgery and Oral Medicine 34093 Capa,Istanbul- TURKIYE",institutionString:null,institution:null},{id:"172009",title:"Dr.",name:"Fatma Deniz",middleName:null,surname:"Uzuner",slug:"fatma-deniz-uzuner",fullName:"Fatma Deniz Uzuner",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/172009/images/7122_n.jpg",biography:"Dr. Deniz Uzuner was born in 1969 in Kocaeli-TURKEY. After graduating from TED Ankara College in 1986, she attended the Hacettepe University, Faculty of Dentistry in Ankara. \nIn 1993 she attended the Gazi University, Faculty of Dentistry, Department of Orthodontics for her PhD education. After finishing the PhD education, she worked as orthodontist in Ankara Dental Hospital under the Turkish Government, Ministry of Health and in a special Orthodontic Clinic till 2011. Between 2011 and 2016, Dr. Deniz Uzuner worked as a specialist in the Department of Orthodontics, Faculty of Dentistry, Gazi University in Ankara/Turkey. In 2016, she was appointed associate professor. Dr. Deniz Uzuner has authored 23 Journal Papers, 3 Book Chapters and has had 39 oral/poster presentations. She is a member of the Turkish Orthodontic Society. 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Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. 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