Computed rates (in Hz) of both static algorithms.
\r\n\tThere will be a chapter on secondary causes of sexual dysfunction disorders related to diabetes, cardiovascular disease, and obesity. A chapter on remedial measures to enhance sexual activity and maintain human relationships will be discussed. As there is a growing number of cancer survivors a chapter on cancer-related sexual dysfunction will be welcomed for including it.
",isbn:null,printIsbn:null,pdfIsbn:null,doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,hash:"b988fda30a4e2364ee9d47e417bd0ba9",bookSignature:"Dr. Dhastagir Sultan Sheriff",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11889.jpg",keywords:"Sex, Sexual Response Cycle, Erection, Premature Ejaculation, Libido, Orgasm, Painful Intercourse, Psychological, Female, Lack of Desire, Erectile Disorders, Pain Disorders",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"April 8th 2022",dateEndSecondStepPublish:"May 6th 2022",dateEndThirdStepPublish:"July 5th 2022",dateEndFourthStepPublish:"September 23rd 2022",dateEndFifthStepPublish:"November 22nd 2022",remainingDaysToSecondStep:"17 days",secondStepPassed:!0,currentStepOfPublishingProcess:3,editedByType:null,kuFlag:!1,biosketch:"Dhastagir Sultan Sheriff is a life member of the European Society for Human Reproduction and Early Human Development, Association of Physiologists and Pharmacologists of India, member of the National Academy of Medical Sciences, New Delhi, and resource person for UNESCO for Medical and Bioethics. 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In addition, swarms of robots are widely employed in complex tasks that cannot be performed by a single robot or in tasks that are better achieved by cooperation of robots such as localization in formations [7], target tracking [8], mapping and localization [9], object pushing [10], area exploration for search and rescue [11], etc. When swarms of mobile robots are teleoperated, specific network requirements should be satisfied in order to guarantee a minimum quality of control, which results in efficient task execution. Research done on teleoperated systems showed that constraints such as bandwidth and CPU processing cause the Quality of Service (QoS) to degrade to an extent that may severely affect performance [12, 13]. To address this problem, various bandwidth management algorithms have been presented for distributed multimedia systems in order to maintain a performance that guarantees an adequate QoS [6]. However, the literature rarely tackled the problem of managing bandwidth based on sensory feedback and the quality of collaboration among robots. Accordingly, a real-time dynamic optimized bandwidth management for teleoperation of collaborative robots is introduced in this paper. The proposed method accounts for interesting events (IEs) and the change in the quality of collaboration (QoC) between robots in order to optimize the allocation of bandwidth between acting agents, where necessary, in a given environment. The developed optimization technique showed outstanding performances when implemented on a system of two collaborating humanoid robots, and thus could be considered a basis for a framework for highly complex algorithms implemented in systems involving real-time bandwidth optimization, where multiple users control multiple collaborating robots.
\nDifferent types of resource management algorithms are used to solve the bandwidth allocation problem in robotics systems. Such applications in networked control systems fall into two main categories: static [14] and dynamic [15] bandwidth allocation. Static methods cannot adapt to changes in the system state (surrounding environment, collaboration quality, etc.). Alternatively, dynamic bandwidth allocation algorithms increase performance at the cost of increased computation. Mourikis et al. [7] address the problem of resource allocation in formations of mobile robots localizing as a group. The goal is to determine the frequency at which each individual sensor should be used in order to attain the highest possible localization accuracy. The set of frequencies mentioned is obtained by solving an optimization problem that maximizes the accuracy matrix expressed in terms of the sensors\' frequencies. However, the problem is solved offline and the algorithm does not account for any dynamic events that might occur. Sugiyama et al. [8] propose a bandwidth reservation algorithm for multi-robot systems in a target tracking mission. The interesting information, corresponding to a survivor’s detection, is sent to the base station with wideband signals such as dynamic picture images. The final call is left to operators to decide whether the received images indicate a real victim, by allowing/preventing the corresponding robot to reserve the bandwidth affecting the flow of various signals from other robots to the base station. In this approach, the operator\'s intervention is crucial in allocating bandwidth and thus the allocation process is not fully automated. Xi et al. [5] developed a bandwidth allocation mechanism based on online measured task dexterity index of dynamic tasks so that operators can control remote manipulators efficiently and smoothly even under poor network quality. However, the executed task is simple and does not require the collaboration of multiple robots to be performed. Thus, the quality of collaboration factor is not considered in the bandwidth allocation. Finally, in [10], a bandwidth management algorithm is introduced and the rate of feedback is regulated based on the amount of activities occurring in the environment. The work shows that during complex tasks, the operator\'s performance is affected by the rate of feedback of information. It is also confirmed that a higher sampling rate is required to maintain the same level of performance obtained when the environment is less dynamic. Yet, the implemented algorithm does not impose any constraint on the total bandwidth of the system. In addition, the notion of monitoring changes in QoC to allocate bandwidth is not mentioned since the task execution only requires the use of a single robot. To the best of the author\'s knowledge, there was limited research addressing bandwidth management for the specific application of collaborative robots teleoperation. In 2015, Ricardo and Guilherme designed a Dynamic Bandwidth Management Library to control the frequency of individual sensors present in a robotic environment performing a certain task [16]. This work is seeking a universal Dynamic Bandwidth Management Library designed to be used on a system with a variable number of heterogeneous robots performing any collaborative task that requires communication transactions such as the exchange of sensor data between involved agents.
\nAccordingly, the main contribution of the work presented in this paper is in accounting for (a) IEs occurring in the robotic swarm\'s environment and (b) changes in QoC among the swarm of robots in real-time optimized bandwidth management of teleoperated collaborative robots. Consequently, assessing the multi-robot swarm dynamics, the stability of the robotic swarm and the effects of packet loss and transmission delay under the proposed algorithm falls out of the scope of this paper. Factoring the latter into the proposed algorithm is possible but will alter the emphasis from the main contribution of dynamic optimized bandwidth management.
\nA literature review of the most relevant work in bandwidth management was presented in Section 1. The general problem is formulated in Section 2. The formulation is then implemented on an application in which an operator drives two collaborating robots. Section 3 describes the experimental set-up and the corresponding results. Finally, conclusions are presented in Section 4.
\nThe focus of the work presented is on real-time dynamic managing of the ‘User’ to ‘Robot’ and ‘Robot’ to ‘User’ (U2R/R2U) and ‘Robot’ to ‘Robot’ (R2R) communication channels, where actuation commands, system state and sensory data including video frames are exchanged. A general formulation of the problem that can be applied to swarms with a variable number of collaborating robots is presented first and is then implemented on a formation of two humanoid robots performing a collaborative task. The formulation is concluded by presenting the solution of the optimization problem.
\nThe goal of the optimized dynamic bandwidth allocation algorithm is to optimize communication at each time event based on information related to the occurrence of
Let the collaborative task be executed by
Where the elements of X are classified into 3 sets of rates:\n
Feedback Rates: R2U communication rates
Collaboration Rates: R2R communication rates
Command Rates: U2R communication rates
The rates
Distance to obstacles, speed and displacement of robot are potential examples of
In the formulation presented in this work, a mapping equivalent to the one presented in our previous work [17] is applied, however, with additional constraints that transform the problem from a simple matrix multiplication to a linear optimization problem. The new constraints bound the set of feasible communication rates
In this mathematical formulation,
Then, an r-dimensional vector
Hence, at each time instant, the algorithm solves for the
In (7), the elements of the matrix
Since the sum of bandwidth consumed on all channels is bounded by the maximum bandwidth of the system,
Minimize:\n
Since
which is equivalent to
\nThe constraint in (12) can be expressed in terms of matrix multiplication as follows:\n
Therefore, for any collaborative task, it is sufficient to set the parameters in Eq. (13) in order to define the linear optimization problem. Thus, optimization techniques can be applied to solve the defined problem.
\nIn order to solve the aforementioned problem, a simple change of variable is first performed. We let:\n
Therefore, the problem formulation becomes minimize:\n
Since the problem is an L1 norm problem, it needs to be slightly modified in order to get rid of the absolute value that complicates the solution of the problem. Thus, the problem can be translated to minimize:\n
In order to illustrate the use of the formulation, we apply it for the case, where an operator drives two collaborating robots. The mission consists of navigating a delimited path to reach a predetermined destination while avoiding obstacles and preserving a formation. The formation is characterized by a distance of 60 cm that separates the two robots, while keeping alignment nearly zero as in Figure 1.
\nTwo robots in a formation requiring a fixed distance D = 60 cm. (a) Without error (b) with vertical and horizontal error.
The robots\' feedback includes visual and haptic data reflecting the environmental conditions. Ultrasonic sensors mounted on each robot allow the detection of obstacles in the navigation path. Each returns an integer value, indicating the distance to the nearest detected obstacle, which is fed back to the operator in the form of haptic feedback. In addition, the camera mounted on top of each robot provides visual feedback of the area in front of the formation. In order to allocate bandwidth based on changes in task conditions,
The observations in
Each element of
Knowing that the maximum distance detected by the robots\' sensors is 2.5 m,
Given that
Finally,
Additionally, the maximum allowed positioning error in the horizontal and vertical directions
Furthermore, the experiment is performed for a maximum bandwidth
In addition, the matrices
Finally, a fixed matrix
In the experiments, the aforementioned values of
In this section, the suggested algorithm is evaluated against two static allocation algorithms: ‘Equal Bandwidth’ and ‘Equal Rates’. The equal bandwidth method allocates bandwidth equally among the different streams, while the equal rates method divides the available bandwidth such that the different streams would have equal rates of transmission.
\nThe experimental set-up is composed of two NAO humanoid robots driven in a certain formation. An operator drives the two robots using a force feedback joystick (Microsoft SideWinder Force Feedback 2) and communicates with the robot through a router connected to a PC as shown in Figure 2. The operator sends real-time commands to the agents that return back haptic feedback as proximity measures and visual feedback from cameras mounted on each robot. The signal flows within the different components of the system as illustrated in Figure 3. The collaborative task that is to be accomplished by the robots is to maintain a certain formation while traversing an environment and avoiding collision with potential obstacles. The formation is characterized by a fixed distance (D = 60 cm) separating the two robots, while maintaining the error in the vertical direction nearly zero. Accurate position of the humanoids is calculated using the aid of the Inertial Unit built in the robots, which is made of 2-axis gyrometers with 5% precision (
Experimental set-up.
Teleoperation experimental set-up of humanoid robots.
The first scenario consists of driving the swarm in the space delimited by dashed lines, shown in Figure 4, and reaching the final destination (dashed rectangular region on the right side) with no obstacles in the path. Obviously, with the absence of obstacles, the shortest path in this case is moving from ‘Start’ to ‘End’ in a straight line. The operators tend to adopt the shortest path, the straight line in this case, to reach the final destination.
\nScenario 1—path with no obstacles.
In the second scenario, an obstacle is detected in front of Robot 1 (dashed square) when driving the formation in the delimited area as shown in Figure 5. The operator should steer to the left in order to avoid the collision with the obstacle. The swarm is forced to steer toward the left since by steering in the opposite direction Robot 2 would then exit the delimited path.
\nScenario 2—obstacle in front of R1.
The third scenario features an obstacle in front of Robot 2 (dashed square) when driving the formation in the delimited area. In this case, the operator steers to the left in order to avoid the collision of Robot 2 with the obstacle as shown in Figure 6.
\nScenario 3—obstacle in front of R2.
In order to evaluate the suggested algorithms, for each scenario, teleoperators drove the swarm under the Equal Bandwidth, Equal Rates and Optimized Bandwidth method. In each trial, the following performance parameters are collected: the completion time in
\n | |||||||
---|---|---|---|---|---|---|---|
1 | \n8 | \n1 | \n8 | \n8 | \n8 | \n1.43 | \n|
1.5 | \n1.5 | \n1.5 | \n1.5 | \n1.5 | \n1.5 | \n1.42 | \n
Computed rates (in Hz) of both static algorithms.
The path in front of the formation can be visualized by the cameras located on the forehead of each robot. Robots R1 and R2 navigate inside a delimited path while avoiding obstacles to reach the final destination. Moreover, a force feedback that corresponds to the distance to obstacles in front of the formation is calculated based on values measured by the ultrasonic sensors mounted on each robot. In order to evaluate the suggested algorithm, four teleoperators drove the formation under the three allocation methods in the three defined scenarios for a total number of runs equal to 36. Under each scenario, the bandwidth methods were
Referring to Table 2, at an average bandwidth consumption less than that of both static algorithms, dynamic optimized bandwidth allocation method results in a better performance in the first scenario. With a reduction in bandwidth consumption of around 70 Kbps, the operator performs better when using the proposed dynamic algorithm than when applying the static ones. With the dynamic bandwidth algorithm, the average trial duration is 1.9 s less than the best static allocation method. Moreover, the driving performance improved significantly, since the parameters measuring the average error with respect to the shortest path improved in addition to the average speed of both robots. The instantaneous error to the shortest path has decreased by around 0.15 cm for both robots, while the average speed of both robots is around 0.35 cm/s higher. As for the parameters reflecting the quality of the executed collaborative task, we remark that the dynamic algorithm performs better than both static methods. The average errors in the horizontal and vertical directions are smaller as well as the maximum error is in both directions. For instance, the average horizontal error decreased by 10% for around 0.05 cm, while the average vertical error decreased by 40% (0.19 cm). It is worth noting that for most parameters the proposed method has a lower standard deviation indicating a more consistent performance.
\n\n | \n | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Average | \n35.2 | \n4.53 | \n4.73 | \n0.52 | \n0.53 | \n0.75 | \n0.48 | \n2.63 | \n3.95 | \n1.40 | \n|
\n | Std Dev | \n1.13 | \n0.17 | \n0.23 | \n0.15 | \n0.19 | \n0.56 | \n0.23 | \n1.28 | \n1.30 | \n0.00 | \n
Average | \n34.2 | \n4.71 | \n4.91 | \n0.43 | \n0.47 | \n0.54 | \n0.59 | \n1.99 | \n2.92 | \n1.40 | \n|
\n | Std Dev | \n5.26 | \n0.77 | \n0.77 | \n0.09 | \n0.10 | \n0.37 | \n0.18 | \n1.25 | \n1.21 | \n0.00 | \n
Average | \n32.3 | \n5.04 | \n5.27 | \n0.37 | \n0.41 | \n0.49 | \n0.29 | \n1.32 | \n1.33 | \n1.33 | \n|
\n | Std Dev | \n4.39 | \n0.45 | \n0.45 | \n0.05 | \n0.05 | \n0.34 | \n0.18 | \n0.79 | \n0.69 | \n0.0015 | \n
Results of Scenario 1 at 1.4 Mbps.
In Scenario 2, the advantage of dynamic bandwidth allocation is also demonstrated by the collected results in Table 3. With a reduction in bandwidth consumption of around 70 Kbps, the operators perform better when using the proposed dynamic algorithm than when applying the static ones. With the dynamic bandwidth algorithm, the average trial duration is 3.7 s less than the best static allocation. Moreover, the driving performance improves significantly, since the parameters measuring the average error with respect to the shortest path improve in addition to the average speed of both robots. The instantaneous error to the shortest path decreased by around 0.4 cm, while the average speed of both robots is around 0.35 cm/s higher. Additionally, the maximum errors in the horizontal and vertical directions decreased by around 0.35 cm. It is worth noting here that the runs performed with ‘Equal Rates’ method lead to a better average horizontal and vertical error; however, with this method, high peaks of errors are reached in both directions that almost reach the tolerated bounds of 2.5 and 5 cm.
\nThe rates of visual feedback of robots R1 and R2 during Scenario 3 for the different adopted bandwidth algorithms are presented in Figure 7. Additionally, the rates of haptic feedback of robots R1 and R2 and the collaboration and commands rate during Scenario 3 for the different bandwidth algorithms are presented in Figures 8 and 9, respectively.
\nFurthermore, we examine the percentage of runs in which the suggested algorithm outperforms the two static algorithms for each performance parameter in all scenarios. In other words, we count the number of times a user performed better according to a parameter when adopting the dynamic algorithm versus when driving with each of the static algorithms. Percentage of best performance for task duration, average speed of each robot (Speed R1, Speed R2), error of each robot with respect to the shortest path (Esp1 and Esp2) and maximum alignment and separation errors in the formation are recorded in Table 5. From the collected results, it can be seen that operators perform better with the dynamic allocation algorithm than the static algorithms at a minimum of 67% of the runs (Esp1 and Esp2 with Equal Bandwidth and Max horizontal/vertical error with Equal Rates). The suggested algorithm reaches a success rate of 92% for the speed R1 with respect to ‘Equal Rates’ static allocation.
\n\n | \n | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Average | \n45.3 | \n4.01 | \n4.17 | \n7.49 | \n7.51 | \n0.54 | \n0.51 | \n2.60 | \n3.39 | \n1.40 | \n|
\n | Std Dev | \n1.49 | \n0.34 | \n0.32 | \n2.10 | \n2.02 | \n0.24 | \n0.14 | \n0.72 | \n0.61 | \n0.00 | \n
Average | \n46.1 | \n4.15 | \n4.34 | \n5.92 | \n5.98 | \n0.37 | \n0.42 | \n2.25 | \n4.66 | \n1.40 | \n|
\n | Std Dev | \n3.83 | \n0.03 | \n0.07 | \n0.31 | \n0.33 | \n0.20 | \n0.37 | \n1.64 | \n4.88 | \n0.00 | \n
Average | \n41.6 | \n4.49 | \n4.66 | \n5.62 | \n5.46 | \n0.65 | \n0.49 | \n2.23 | \n2.61 | \n1.33 | \n|
\n | Std Dev | \n2.21 | \n0.21 | \n0.24 | \n0.82 | \n0.89 | \n0.15 | \n0.23 | \n0.53 | \n1.96 | \n0.0002 | \n
Once more, the results collected during the experiments performed in Scenario 3 have shown the advantages of the suggested dynamic allocation method as depicted in Table 4. The parameters measuring the quality of the collaborative task and the driving performance show real improvements. It is worth noting that in Scenario 3, the average task duration with the dynamic bandwidth method is equal to the average duration with equal bandwidth method. However, three of the four drivers have performed better with the suggested algorithm than with static bandwidth allocation. Only one user performed the trial with a total duration of 53 s. This trial biased the calculated average, which was reflected by the standard deviation value.
Results of Scenario 2 at 1.4 Mbps.
\n | \n | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Average | \n47.5 | \n4.09 | \n4.23 | \n7.55 | \n7.52 | \n0.66 | \n0.63 | \n7.66 | \n4.93 | \n1.4 | \n|
\n | Std Dev | \n2.31 | \n0.38 | \n0.45 | \n2.31 | \n2.39 | \n0.64 | \n0.27 | \n7.62 | \n1.95 | \n0.00 | \n
Average | \n49.3 | \n3.99 | \n4.00 | \n9.03 | \n9.09 | \n0.66 | \n0.88 | \n2.35 | \n6.32 | \n1.4 | \n|
\n | Std Dev | \n2.47 | \n0.16 | \n0.21 | \n1.27 | \n1.16 | \n0.25 | \n0.54 | \n0.98 | \n6.04 | \n0.00 | \n
Average | \n47.5 | \n4.15 | \n4.27 | \n6.78 | \n6.81 | \n0.36 | \n0.23 | \n1.43 | \n2.90 | \n1.33 | \n|
\n | Std Dev | \n4.40 | \n0.23 | \n0.28 | \n1.16 | \n1.15 | \n0.24 | \n0.15 | \n0.76 | \n2.52 | \n0.0010 | \n
Results of Scenario 3 at 1.4 Mbps.
Visual rates of R1 & R2 in Scenario 3.
Haptic rates of R1 & R2 in Scenario 3.
Finally, the advantages of the proposed dynamic bandwidth optimization and management scheme over legacy bandwidth management schemes are clearly expressed in the results in terms of performance improvement and conserving network resources. Since the proposed algorithm is scalable and not limited to a single task, the improvement in performance is greatly realized in critical situations, where the collaborative task requires high levels of accuracy especially in cases involving human safety.
\nCollaboration & commands rates in Scenario 3.
\n | Duration (%) | \nSpeed R1 (%) | \nSpeed R2 (%) | \nEsp1 (%) | \nEsp2 (%) | \nMax horizontal error (%) | \nMax vertical error (%) | \n
---|---|---|---|---|---|---|---|
Dynamic vs. equal bandwidth | \n83 | \n75 | \n83 | \n67 | \n67 | \n83 | \n83 | \n
Dynamic vs. equal rates | \n75 | \n92 | \n83 | \n83 | \n83 | \n67 | \n67 | \n
Percentage of best performance.
In this work, dynamic optimized bandwidth management in teleoperated collaborative robotics is tackled. The focus was on managing all communication channels, where actuation commands, system state and sensory data are exchanged. This was achieved by monitoring the interesting events occurring in the robots\' environment and the changes in quality of collaboration among them. Effective completion of the collaborative task with lower bandwidth consumption and better performance was accomplished proving that the proposed method could be the basis of a framework for developing more complex algorithms applied to highly complex systems.
\nThis research was funded and supported by AUB University Research Board and the Lebanese National Council for Scientific Research.
\nThe enrichment of lakes and reservoirs with nutrients leads to an increase in the growth of algae, especially cyanobacteria, forming floating masses on the surface, causing a decrease in the concentration of dissolved oxygen and death in fish, and the death of livestock and other animals as a result of ingesting algae toxins. Filamentous cyanobacteria and green algae (Chlorophytes) cause clogging in filters of water treatment systems or problems in industrial systems when such water is used. The dinoflagellates are another group of phytoplankton that can secrete toxic substances. One of the by-products of algal blooms are high concentrations of organic carbon [1]. Increased phosphorous concentration and low P:N ratio are major factors for such a condition, and several studies indicate that toxins from cyanobacteria pose a health risk. According to the World Health Organization (WHO), the maximum acceptable concentration of the toxic substance (Microcystin-LR) in tank water that may be used for drinking is (0.5–1.0 μg/cubic decimeter), as exposure to an increase of this substance causes liver cancer. Human exposure to this type of poison is possible because it is difficult to carry out a complete treatment of cyanobacterial toxins in drinking water plants. Cyanobacteria also cause the death of animals when they ingest these toxins and also lead to a lack of oxygen and the death of fish [2]. Algae are distributed worldwide in the sea, in freshwater and in wet situations on land. Most are microscopic algae, but some of them are so large, also some marine seaweeds that can exceed 50 m in length. The algae have chlorophyll and can make their own food through the steps of photosynthesis. Recently they are classified in the kingdom of protiste, which include a variety of unicellular and some basic multinuclear and multicellular eukaryotic organisms that have cells. Algal poisoning is an intense, often lethal condition caused by high concentrations of toxic blue-green algae (more commonly known as cyanobacteria—literally blue-green bacteria) in drinking water as well as in water used for recreation, agriculture and aquaculture. Severe illness of livestock and Fatalities, birds, pets, fish and wildlife from high growths of cyanobacteria water blooms occur almost in all of the countries in the world. Severe deadly poisonings have also been notarized in people. Poisoning usually comes during warm seasons when the water blossom are more acute and of longer duration. Almost poisonings come among animals drinking cyanobacteria infested freshwater, but aquatic animals, mostly mariculture fish and prawn, are also affected. The toxins of cyanobacteria comprise six special chemical classes collectively called cyanotoxins [3]. Toxic algae, micro-algal blooms, phytoplankton blooms, red tides, or harmful algae, are all terms for normally occurring phenomena. Around 300 species of micro algae are notify at times to form mass appearance, so called blooms. About one fourth of these species are recognized to produce toxins. The scientific society points out to these events with a generic term, ‘Harmful Algal Bloom’ (HAB), understanding that, because a wide range of organisms are implicated and some species have toxic impacts at low cell intensity, not all HABs are ‘algal’ and not all occur as ‘blooms’ [4]. Many of the organisms in charge for red tides are closely distributed and, in recent years, the organisms appear to be markedly spreading. Natural events such as hurricanes can spread over organisms, and it is doubtful that some organisms may be moved long distances in ship ballast waters. Another factor that may motivate algal proliferation in both freshwater and marine systems is augmentation nutrient loading. Certain algae occur more usually in some areas than others and it is useful to know which ones are problems in particular locations. Good sources of information about algal blooms are the State public health department or the State division of marine resources or marine fisheries [5].
Water, especially surface water, is exposed to the dangers of pollution, as the water source is considered polluted when it directly or indirectly changes its composition or condition as a result of human action, that is, if it becomes less suitable for some or all uses. These include sewage, household waste, hospital wastewater, and rainwater, where these pollutants are loaded with large quantities of various organic and inorganic materials and many types of microorganisms that cause many diseases, as well as urination, defecation, and throwing dead animals into the water, especially in rural areas, as well as picnic places represented by excreta. and food waste, where the type of sewage network systems plays a major role in the aggravation of these pollutants, as there are two types of sewage network systems in Baghdad, which are the separate system and the combined system. Also, the term (red tide) is considered to refer to types of Plankton (phytoplankton) that are spread in high density in any water body (may reach more than ten million cells per liter) and are known as harmful algae. Of the (4400 species) of Plankton plant there are only from (50–60 poisonous species). One of the most important spread of the phenomenon of red tide is a defect in environmental factors, including the difference in the ratio of phosphorous to nitrogen through sewage pollution. The higher the phosphorous rate in the water mass, the higher the rate of red tide or harmful algae appearing with the availability of other environmental conditions. The effects of the red tide are the destruction of fish from economic fish farms if this phenomenon spreads in the farm and costs thousands or even millions of dollars annually. The eyes, nose and mouth are irritated during the presence of algae toxins in the tourist beaches. The toxins increase the toxicity rate of marine food, which is transmitted to humans through marine meals (Figure 1).
Fish damage through the spread of toxin-producing algae.
Industrial and domestic flows result in high concentrations of pollutants that find their way into natural waters, and they are among the primary factors that lead to the deterioration of water quality. As it is known, one of the reasons for the occurrence of nutritional enrichment is the influx of these pollutants containing high concentrations of nutrients estimated at more than (four times) than what is present in natural waters. Therefore, reducing or limiting these sources of pollution is the first successful and important step for water quality management. It is easy to control the known sources of pollution using treatment methods, the most important and most effective of which is the establishment of wet areas (Wetlands) (Figure 2).
Nutritional enrichment in the waters of the Iraqi marshes.
Sources that cause problems that are difficult to control and unknown sources of pollution prepare more nutrients resulting from the modification that humans make in nature such as deforestation, agriculture, industrial and urban development. These sources supply fresh water with low concentrations of nutrients, but it is difficult to control because they are transferred to water bodies from the vast surrounding lands. The preparation of these sources increases in the heavy rainy season, which leads to erosion in the surface of the soil and then filtering of these nutrients from the soil to the aquatic organisms. Man directly and indirectly affects the occurrence of the phenomenon of food enrichment from several aspects, in addition to the industrial, household and agricultural waste it raises. There are many sources of pollutants affecting the Tigris River, including human pollutants, industrial pollutants, agricultural pollutants, and pollutants resulting from groundwater, and thus affected the physical, chemical and biological characteristics, which can be broadly classified into:
Cyanobacteria create a variety of toxic secondary metabolites that are detrimental to a variety of other organisms. Scientists feel that these pollutants are currently posing a serious threat to society’s health in numerous parts of the world. The toxins produced by cyanobacteria and the species that produce them are listed in Table 1. Toxins produced by cyanobacteria are divided into two categories: cytotoxins and biotoxins [7]. The varieties of algal toxins produced by various blue-green algae, as well as their impacts, are listed in Table 1.
Toxin types | Cyanobacteria genera | Effect of toxins |
---|---|---|
Hepatoxins Microcystin Nodularin | These toxins directly affect the zooplankton community, especially those that prefer cyanobacteria species as an important food source for them | |
Neurotoxins Anatoxin-a Homoanatoxin-a Anatoxin-a (s) Saxitoxin | Infection with these types of toxins leads to the inability to breathe and then death through paralysis of the respiratory muscles | |
Cytotoxin Cylindrospermopsin | Its toxic effect on the liver, but it was found that it affects the kidneys as well, causing the destruction of the tissues that it attacks | |
Lipopolysaccharides (LPS) | Many species of Cyanobacteria | These substances have a toxic effect that causes ill health in humans, and it was also found that they are fatal to mice when injected into the peritoneal membranes |
Cyanotoxins with public health significance from acute exposures [6].
This type of toxin is produced by some marine cyanobacteria species, and while it has no harmful effects on animals, it is poisonous to cells generated in cell cultures and inhibits the growth of a wide spectrum of microorganisms. Toxins such as these are examples (Tolytoxin, Tubericidin, Scytophycins and Actiphycins). Indolocarbazoles, tautazoles, microbilinisonitriles, and paracyclophares are more examples).
These compounds are made by cyanobacteria, which can have a variety of negative health consequences on humans and animals, and are frequently lethal. Toxins are categorized into three categories: neurotoxins, hepatotoxins, and endotoxins [7].
Alkaloids are poisonous in a short amount of time and are usually lethal, as they cause paralysis of the surrounding skeletal muscles, followed by paralysis of the respiratory muscles, resulting in incapacity to breathe and death. Several forms of these toxins have been identified (e.g.,
Toxins of this sort cause a variety of types and strains that belong to the genera (
They’re monocyclic seven-chain peptides with an unique amino acid named Adda connecting the side chains. Because the peptide ring comprises five amino acids that are used in the synthesis of all forms of microcystins produced by the species (
It’s a pentacyclic monocyclic peptide that looks a lot like MC–LR but is smaller. The peptide ring has a molecular weight of 824 Da and comprises amino acids similar to those found in MC–LR. Only one variety has been identified as being produced by the species (
It is one of the toxins produced by the type (
It refers to the lipo polysaccharide (LPS) that forms the cell wall of pan cyanobacteria, and it has been discovered that these chemicals are hazardous to humans. When injected into the peritoneal membranes at a dose of (1–1.2 mg/kg after 48 h), it was likewise proven to be deadly to rats [12].
Many researches have confirmed that the compounds produced by various varieties of cyanobacteria are harmful to many animals and humans, as they have been discovered to cause the death of many creatures in many parts of the world, including cattle, horses, dogs, birds, fish, and crocodiles. These toxins have a direct impact on society Zooplankton, particularly those that prefer cyanobacteria species as a major food source, such as the genus Daphnia, where it was discovered that low concentrations of these toxins reduce the ability of these organisms to reproduce new generations, as well as their members’ growth rates. Toxic levels above a certain threshold cause death [13]. The use of water contaminated with microcystins in the dialysis process in a hospital’s hemodialysis unit, which resulted in damage Acute hepatitis, confirms the seriousness of these toxins, as the worst accident recorded so far occurred in 1996, with the victim (60 patients) due to the use of water contaminated with microcystins in the dialysis process. Due to the usage of recycled water for drinking, Western culture is one of the societies most exposed to these poisons, as proven by two occurrences in Australia. Due to pollution of drinking water with these chemicals, the first victim (139 children) and a number of adults became infected, resulting in severe liver, hematuria, renal failure, and death. The high concentration of toxin in the drinking water was caused by the chemical treatment of water containing blooming algae (
Environmental parameters such as temperature, illumination, pH, salinity, macro- and micronutrients are among the most important regulators of toxins production from blue-green algae, according to environmental studies in continuous cultures of algae. Microcytins and Anatoxin-a are maintained to a significant extent inside the cell. Because the degree of (Microcytins) harm to the environment and neighboring creatures increases as the logarithmic length of growth increases, the presence of (Microcytins) cannot be overlooked. According to certain research, the quantities of toxins in water containing creatures that emit toxins range from (1–100 g/l) and can be higher, and as a result, (microcytins) are among the contents that pose a health risk and have an effect if the water has been ingested from change the detoxification of cyanobacteria and their cells [15].
After reducing the quantity of algae that produces food enrichment (excessive growth), a potassium permanganate mixture with a concentration of 30 mg/l textured alum as coagulate was used. The concentrations of chlorophyll algal toxins per transaction were examined and compared to the standard at the end of the 72-h experiment mediated by the GC/MS device, in addition to reducing the productivity of the initial algae by reducing the concentrations of chlorophyll algal toxins per transaction. The results revealed the presence of algal toxins belonging to the groups Neurotoxins, Hepatotoxins, Pyriproxyfen, Emodin, Brevetoxins-10 (A), and Cytotoxins in the standard treatment, with a note detoxification algal 100% concentrations of 8 and 16 mg/l, respectively, textured potassium permanganate in comparison to the standard, which contained a lot of chemical compounds to algal toxins (Figure 3).
GC-MASS of algal toxins within the treated standard.
A result of the cessation of photovoltaic installation process stops the outer wall systems (systems enzymatic) to withdraw nutrients that enter into the composition of the algal toxin combination the non-arrival of light to stop light receptors [16], and the concentrations of 2 and 4 mg/l for the same article have some toxic compounds converted into non-toxic compounds and Figures 4–8 describe them. Were treated toxins algal belonging to the group Neurotoxins a Besnfein Anatoxin-a, Homoanatoxin-a and the various toxins which is alkaline compounds Alkaloids with effect very quickly called and can be fatal in most cases where the cause muscle surrounding paralysis followed by a respiratory muscle paralysis, which leads to an inability to breathe then death.
GC-MASS of algal toxins within concentration of 2 mg/l.
GC-MASS of algal toxins within concentration of 4 mg/l.
GC-MASS of algal toxins within concentration of 8 mg/l.
GC-MASS of algal toxins within concentration of 16 mg/l.
Concentrations of potassium permanganate and its impact on algae society compared to standard.
These toxins, as seen in Hepatotoxins group Class Microcystin-LA, are the most common among toxins Cyanobacteria and have a severe impact, but death takes longer than nerve toxins, ranging from 5 min to a few days depending on several factors such as the weight of the animal, the type of poison, and the dosage, among others. Other forms of toxins, such as Pyriproxyfen, Emodin, and Brevetoxins-10, were shown to be effective in removing algal toxins that had emerged within the conventional treatment of 8 and 16 mg/l potassium permanganate, as shown in Table 2.
Algal toxins | Synthetic version of the toxin | Standard | Concentrations of potassium permanganate (mg/l) | |||
---|---|---|---|---|---|---|
2 | 4 | 8 | 16 | |||
1-Neurotoxins Anatoxin-a | C2H3C12NO | * | - | - | - | - |
C9H13NO2 | * | - | - | - | - | |
C18H27NO3 | * | - | - | - | - | |
C11H12N2O6 | * | - | - | - | - | |
C11H17N3O | * | - | - | - | - | |
C10H17N3O | * | - | - | - | - | |
C9H15Br2NO | * | - | - | - | - | |
Homoanatoxin-a | CH4N2O2 | * | - | - | - | - |
C11H17NO2 | * | - | - | - | - | |
C13H9BrN2O3 | * | - | - | - | - | |
2-Hepatotoxins Microcystin- LA | ||||||
C3H7NO4S | * | - | - | - | - | |
3-Pyriproxyfen | C20H29NO3 | * | - | - | - | - |
4-Emodin | C15H10O5 | * | - | - | - | - |
5-Brevetoxins-10(A) | C4H8O2 | * | - | - | - | - |
6- Cytotoxins | C2H2Cl3NO | * | - | - | - | - |
Treatment of algal toxins of different concentration of potassium permanganate with chemical formulations statement mediated by GC-MASS.
The presence of toxins.
-, absence of toxins.
The same material with concentrations of 2 and 4 mg/l has been converted into non-toxic and hazardous chemicals, as indicated in Table 2. The current study also suggests that potassium permanganate at concentrations of 8 and 16 mg/l, respectively, could be used to treat algal cells by stopping photosynthesis and disabling all vital events without tearing the outer wall of the moss, and then deposition blocs blooms to the pelvic floor and a rise in turbidity levels in the water column, as opposed to the standard, which shows a rise in biomass value and low turbidity Figure 8. Furthermore, all potassium permanganate concentrations of 2, 4, 8, and 16 mg/l had no effect on the algae’s outer wall. This is because to the potassium permanganate mixture’s precise concentration of alum, which caused the algae’s exterior wall to not tear, preserving the outer toxic blooming. It inhibits photosynthesis, resulting in a decrease in the primary productivity of chlorophyll-producing algae, solution Alum is necessary for the production of potassium permanganate and aids in the sintering, coagulation, and sedimentation processes [17]. Furthermore, potassium permanganate affects some algal toxins but not others, as it affects the toxins anatoxin-a, cylindrospermopsin, and microcystin and analyses have valued the final removal, while it does not affect saxitoxin toxin, despite the fact that it is produced by algae greens blue—this is what the organization confirms [18].
The use of activated carbon for the removal of a wide range of organic compounds, including numerous algal toxins, is a well-accepted treatment approach. Powdered activated carbon (PAC) and granular activated carbon (GAC) can both be used as a physical process to adsorb toxins in source water, while GAC can also be used as a biological process to degrade toxins by allowing bacteria to grow on GAC media (instead of sand or anthracite) in rapid gravity filters. The nature of the source water, particularly the sort of toxins and competing natural organic matter (NOM) constituents present, has a significant impact on the efficacy of the adsorption or biological process. Operators should consider improving reactivation and replacement frequency based on the seasonal prevalence of blue-green algae if GAC is currently being used. Because algal toxin occurrences occur on a regular or seasonal basis, the use of PAC can be beneficial because it may be introduced sporadically to the traditional treatment procedure to react to the presence of toxins in a relatively cost-effective manner.
PAC can be added before coagulation and removed in the settling tanks, or it can be added after coagulation and removed by filtering. When employing PAC, keep in mind that it must be removed by a downstream operation and discarded, as PAC is rarely reused or regenerated. When utilizing PAC, detention times must be considered to ensure that enough time is provided for adequate adsorption removal. Prior to coagulation, PAC basins are occasionally employed, but care must be taken to ensure that the PAC adsorption rate correctly accounts for any NOM compound competition for adsorption sites. For details on selection and dosing, contact your PAC supplier.
Chlorination (gaseous elemental chlorine, liquid sodium hypochlorite, or calcium hypochlorite), chloramines, chlorine dioxide, potassium permanganate, and ozone are all examples of oxidation in this section. UV with hydrogen peroxide is also demonstrated. Because most oxidants will lyse the blue-green algae cells present and release their toxins, peroxidation (the administration of an oxidant at any point in the treatment process prior to filtering) is not suggested. To keep the cell structure intact and the toxins contained, blue-green algae cells should be removed during the coagulation process before adding an oxidant if at all possible (i.e., intracellular). Water systems should consider using a weaker oxidant such as potassium permanganate if pre-oxidation is required for acceptable turbidity and/or organic carbon removal.
Chlorine reacts with microcystins, cylindrospermopsin, and saxitoxins to a lesser amount. Anatoxin-a does not seem to react well with chlorine. In addition, saxitoxin inactivation works best at higher pH levels, whereas microcystin inactivation works best at lower pH levels. The pH of the water and the presence of NOM affect the reactivity of chlorine with contaminants. Depending on the water quality circumstances, the contact time (CT) values necessary for the elimination of microcystins with free chlorine may be many times higher than those required for the surface water treatment rule. Chloramine and chlorine dioxide in commonly used levels have not been shown to be effective against any of the four poisons. Chloramines are effective against microcystins at very high doses and over long periods.
Microcystins, anatoxin-a, and cylindrospermopsin react more quickly with ozone than with other common oxidants. Saxitoxin is the one that is least affected by ozone. Only 20% of the saxitoxins present would be destroyed under equivalent settings when microcystins would be fully removed. Although hydrogen peroxide alone is ineffective in removing pollutants, ozone combined with hydrogen peroxide is significantly more powerful (Table 3).
Anatoxin-a | Cylindrospermopsin | Microcystin | Saxitoxin | |
---|---|---|---|---|
Chlorine | Not effective | Effective | Effective | Somewhat effective |
Chloramine | Not effective | Not effective | Not effective | Inadequate information |
Chlorine dioxide | Not effective | Not effective | Not effective | Inadequate information |
Potassium permanganate | effective | Date ranges from not effective to possibly effective | Effective | Not effective |
Ozone | Effective | Effective | Effective | Not effective |
UV/advanced oxidation | Effective | Effective | Not effective | Inadequate information |
General effectiveness of blue-green algal toxin inactivation with specific oxidants [19].
Edited by Jan Oxholm Gordeladze, ISBN 978-953-51-3020-8, Print ISBN 978-953-51-3019-2, 336 pages,
\nPublisher: IntechOpen
\nChapters published March 22, 2017 under CC BY 3.0 license
\nDOI: 10.5772/61430
\nEdited Volume
This book serves as a comprehensive survey of the impact of vitamin K2 on cellular functions and organ systems, indicating that vitamin K2 plays an important role in the differentiation/preservation of various cell phenotypes and as a stimulator and/or mediator of interorgan cross talk. Vitamin K2 binds to the transcription factor SXR/PXR, thus acting like a hormone (very much in the same manner as vitamin A and vitamin D). Therefore, vitamin K2 affects a multitude of organ systems, and it is reckoned to be one positive factor in bringing about "longevity" to the human body, e.g., supporting the functions/health of different organ systems, as well as correcting the functioning or even "curing" ailments striking several organs in our body.
\\n\\nChapter 1 Introductory Chapter: Vitamin K2 by Jan Oxholm Gordeladze
\\n\\nChapter 2 Vitamin K, SXR, and GGCX by Kotaro Azuma and Satoshi Inoue
\\n\\nChapter 3 Vitamin K2 Rich Food Products by Muhammad Yasin, Masood Sadiq Butt and Aurang Zeb
\\n\\nChapter 4 Menaquinones, Bacteria, and Foods: Vitamin K2 in the Diet by Barbara Walther and Magali Chollet
\\n\\nChapter 5 The Impact of Vitamin K2 on Energy Metabolism by Mona Møller, Serena Tonstad, Tone Bathen and Jan Oxholm Gordeladze
\\n\\nChapter 6 Vitamin K2 and Bone Health by Niels Erik Frandsen and Jan Oxholm Gordeladze
\\n\\nChapter 7 Vitamin K2 and its Impact on Tooth Epigenetics by Jan Oxholm Gordeladze, Maria A. Landin, Gaute Floer Johnsen, Håvard Jostein Haugen and Harald Osmundsen
\\n\\nChapter 8 Anti-Inflammatory Actions of Vitamin K by Stephen J. Hodges, Andrew A. Pitsillides, Lars M. Ytrebø and Robin Soper
\\n\\nChapter 9 Vitamin K2: Implications for Cardiovascular Health in the Context of Plant-Based Diets, with Applications for Prostate Health by Michael S. Donaldson
\\n\\nChapter 11 Vitamin K2 Facilitating Inter-Organ Cross-Talk by Jan O. Gordeladze, Håvard J. Haugen, Gaute Floer Johnsen and Mona Møller
\\n\\nChapter 13 Medicinal Chemistry of Vitamin K Derivatives and Metabolites by Shinya Fujii and Hiroyuki Kagechika
\\n"}]'},components:[{type:"htmlEditorComponent",content:'This book serves as a comprehensive survey of the impact of vitamin K2 on cellular functions and organ systems, indicating that vitamin K2 plays an important role in the differentiation/preservation of various cell phenotypes and as a stimulator and/or mediator of interorgan cross talk. Vitamin K2 binds to the transcription factor SXR/PXR, thus acting like a hormone (very much in the same manner as vitamin A and vitamin D). Therefore, vitamin K2 affects a multitude of organ systems, and it is reckoned to be one positive factor in bringing about "longevity" to the human body, e.g., supporting the functions/health of different organ systems, as well as correcting the functioning or even "curing" ailments striking several organs in our body.
\n\nChapter 1 Introductory Chapter: Vitamin K2 by Jan Oxholm Gordeladze
\n\nChapter 2 Vitamin K, SXR, and GGCX by Kotaro Azuma and Satoshi Inoue
\n\nChapter 3 Vitamin K2 Rich Food Products by Muhammad Yasin, Masood Sadiq Butt and Aurang Zeb
\n\nChapter 4 Menaquinones, Bacteria, and Foods: Vitamin K2 in the Diet by Barbara Walther and Magali Chollet
\n\nChapter 5 The Impact of Vitamin K2 on Energy Metabolism by Mona Møller, Serena Tonstad, Tone Bathen and Jan Oxholm Gordeladze
\n\nChapter 6 Vitamin K2 and Bone Health by Niels Erik Frandsen and Jan Oxholm Gordeladze
\n\nChapter 7 Vitamin K2 and its Impact on Tooth Epigenetics by Jan Oxholm Gordeladze, Maria A. Landin, Gaute Floer Johnsen, Håvard Jostein Haugen and Harald Osmundsen
\n\nChapter 8 Anti-Inflammatory Actions of Vitamin K by Stephen J. Hodges, Andrew A. Pitsillides, Lars M. Ytrebø and Robin Soper
\n\nChapter 9 Vitamin K2: Implications for Cardiovascular Health in the Context of Plant-Based Diets, with Applications for Prostate Health by Michael S. Donaldson
\n\nChapter 11 Vitamin K2 Facilitating Inter-Organ Cross-Talk by Jan O. Gordeladze, Håvard J. Haugen, Gaute Floer Johnsen and Mona Møller
\n\nChapter 13 Medicinal Chemistry of Vitamin K Derivatives and Metabolites by Shinya Fujii and Hiroyuki Kagechika
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He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null}]},{type:"book",id:"7839",title:"Malaria",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7839.jpg",slug:"malaria",publishedDate:"December 11th 2019",editedByType:"Edited by",bookSignature:"Fyson H. Kasenga",hash:"91cde4582ead884cb0f355a19b67cd56",volumeInSeries:4,fullTitle:"Malaria",editors:[{id:"86725",title:"Dr.",name:"Fyson",middleName:"Hanania",surname:"Kasenga",slug:"fyson-kasenga",fullName:"Fyson Kasenga",profilePictureURL:"https://mts.intechopen.com/storage/users/86725/images/system/86725.jpg",biography:"Dr. Kasenga is a graduate of Tumaini University, Kilimanjaro Christian Medical College, Moshi, Tanzania and Umeå University, Sweden. He obtained a Master’s degree in Public Health and PhD in Public Health and Epidemiology. He has a background in Clinical Medicine and has taken courses at higher diploma levels in public health from University of Transkei, Republic of South Africa, and African Medical and Research Foundation (AMREF) in Nairobi, Kenya. Dr. Kasenga worked in different places in and outside Malawi, and has held various positions, such as Licensed Medical Officer, HIV/AIDS Programme Officer, HIV/AIDS resource person in the International Department of Diakonhjemet College, Oslo, Norway. He also managed an Integrated HIV/AIDS Prevention programme for over 5 years. He is currently working as a Director for the Health Ministries Department of Malawi Union of the Seventh Day Adventist Church. Dr. Kasenga has published over 5 articles on HIV/AIDS issues focusing on Prevention of Mother to Child Transmission of HIV (PMTCT), including a book chapter on HIV testing counseling (currently in press). Dr. Kasenga is married to Grace and blessed with three children, a son and two daughters: Happy, Lettice and Sungani.",institutionString:"Malawi Adventist University",institution:{name:"Malawi Adventist University",institutionURL:null,country:{name:"Malawi"}}}]}]},openForSubmissionBooks:{paginationCount:7,paginationItems:[{id:"11476",title:"Globalization and Sustainability - Recent Advances, New Perspectives and Emerging Issues",coverURL:"https://cdn.intechopen.com/books/images_new/11476.jpg",hash:"8d41fa5f3a5da07469bbc121594bfd3e",secondStepPassed:!0,currentStepOfPublishingProcess:4,submissionDeadline:"March 24th 2022",isOpenForSubmission:!0,editors:[{id:"335401",title:"Prof.",name:"Margherita",surname:"Mori",slug:"margherita-mori",fullName:"Margherita Mori"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11460",title:"Pluralistic Approaches for Conservation and Sustainability in Biodiversity",coverURL:"https://cdn.intechopen.com/books/images_new/11460.jpg",hash:"ab014f8ed1669757335225786833e9a9",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"April 22nd 2022",isOpenForSubmission:!0,editors:[{id:"101105",title:"Dr.",name:"Gopal",surname:"Shukla",slug:"gopal-shukla",fullName:"Gopal Shukla"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11475",title:"Food Security Challenges and Approaches",coverURL:"https://cdn.intechopen.com/books/images_new/11475.jpg",hash:"090302a30e461cee643ec49675c811ec",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"May 5th 2022",isOpenForSubmission:!0,editors:[{id:"292145",title:"Dr.",name:"Muhammad",surname:"Haseeb Ahmad",slug:"muhammad-haseeb-ahmad",fullName:"Muhammad Haseeb Ahmad"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11450",title:"Environmental Impacts of COVID-19 Pandemic on the World",coverURL:"https://cdn.intechopen.com/books/images_new/11450.jpg",hash:"a58c7b02d07903004be70f744f2e1835",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"May 10th 2022",isOpenForSubmission:!0,editors:[{id:"63465",title:"Prof.",name:"Mohamed Nageeb",surname:"Rashed",slug:"mohamed-nageeb-rashed",fullName:"Mohamed Nageeb Rashed"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11477",title:"Public Economics - 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Two Years After",coverURL:"https://cdn.intechopen.com/books/images_new/11573.jpg",subseries:{id:"6",title:"Viral Infectious Diseases"}}},{id:"80546",title:"Streptococcal Skin and Skin-Structure Infections",doi:"10.5772/intechopen.102894",signatures:"Alwyn Rapose",slug:"streptococcal-skin-and-skin-structure-infections",totalDownloads:48,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Streptococcal Infections",coverURL:"https://cdn.intechopen.com/books/images_new/10828.jpg",subseries:{id:"3",title:"Bacterial Infectious Diseases"}}}]},subseriesFiltersForOFChapters:[{caption:"Parasitic Infectious Diseases",value:5,count:1,group:"subseries"},{caption:"Viral Infectious Diseases",value:6,count:1,group:"subseries"},{caption:"Bacterial Infectious Diseases",value:3,count:2,group:"subseries"}],publishedBooks:{paginationCount:0,paginationItems:[]},subseriesFiltersForPublishedBooks:[],publicationYearFilters:[],authors:{paginationCount:249,paginationItems:[{id:"274452",title:"Dr.",name:"Yousif",middleName:"Mohamed",surname:"Abdallah",slug:"yousif-abdallah",fullName:"Yousif Abdallah",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/274452/images/8324_n.jpg",biography:"I certainly enjoyed my experience in Radiotherapy and Nuclear Medicine, particularly it has been in different institutions and hospitals with different Medical Cultures and allocated resources. Radiotherapy and Nuclear Medicine Technology has always been my aspiration and my life. As years passed I accumulated a tremendous amount of skills and knowledge in Radiotherapy and Nuclear Medicine, Conventional Radiology, Radiation Protection, Bioinformatics Technology, PACS, Image processing, clinically and lecturing that will enable me to provide a valuable service to the community as a Researcher and Consultant in this field. My method of translating this into day to day in clinical practice is non-exhaustible and my habit of exchanging knowledge and expertise with others in those fields is the code and secret of success.",institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"313277",title:"Dr.",name:"Bartłomiej",middleName:null,surname:"Płaczek",slug:"bartlomiej-placzek",fullName:"Bartłomiej Płaczek",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/313277/images/system/313277.jpg",biography:"Bartłomiej Płaczek, MSc (2002), Ph.D. (2005), Habilitation (2016), is a professor at the University of Silesia, Institute of Computer Science, Poland, and an expert from the National Centre for Research and Development. His research interests include sensor networks, smart sensors, intelligent systems, and image processing with applications in healthcare and medicine. He is the author or co-author of more than seventy papers in peer-reviewed journals and conferences as well as the co-author of several books. He serves as a reviewer for many scientific journals, international conferences, and research foundations. Since 2010, Dr. Placzek has been a reviewer of grants and projects (including EU projects) in the field of information technologies.",institutionString:"University of Silesia",institution:{name:"University of Silesia",country:{name:"Poland"}}},{id:"35000",title:"Prof.",name:"Ulrich H.P",middleName:"H.P.",surname:"Fischer",slug:"ulrich-h.p-fischer",fullName:"Ulrich H.P Fischer",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/35000/images/3052_n.jpg",biography:"Academic and Professional Background\nUlrich H. P. has Diploma and PhD degrees in Physics from the Free University Berlin, Germany. He has been working on research positions in the Heinrich-Hertz-Institute in Germany. Several international research projects has been performed with European partners from France, Netherlands, Norway and the UK. He is currently Professor of Communications Systems at the Harz University of Applied Sciences, Germany.\n\nPublications and Publishing\nHe has edited one book, a special interest book about ‘Optoelectronic Packaging’ (VDE, Berlin, Germany), and has published over 100 papers and is owner of several international patents for WDM over POF key elements.\n\nKey Research and Consulting Interests\nUlrich’s research activity has always been related to Spectroscopy and Optical Communications Technology. Specific current interests include the validation of complex instruments, and the application of VR technology to the development and testing of measurement systems. He has been reviewer for several publications of the Optical Society of America\\'s including Photonics Technology Letters and Applied Optics.\n\nPersonal Interests\nThese include motor cycling in a very relaxed manner and performing martial arts.",institutionString:null,institution:{name:"Charité",country:{name:"Germany"}}},{id:"341622",title:"Ph.D.",name:"Eduardo",middleName:null,surname:"Rojas Alvarez",slug:"eduardo-rojas-alvarez",fullName:"Eduardo Rojas Alvarez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/341622/images/15892_n.jpg",biography:null,institutionString:null,institution:{name:"University of Cuenca",country:{name:"Ecuador"}}},{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/215610/images/system/215610.jpeg",biography:"Muhammad Sarfraz is a professor in the Department of Information Science, Kuwait University, Kuwait. His research interests include optimization, computer graphics, computer vision, image processing, machine learning, pattern recognition, soft computing, data science, and intelligent systems. Prof. Sarfraz has been a keynote/invited speaker at various platforms around the globe. He has advised/supervised more than 110 students for their MSc and Ph.D. theses. He has published more than 400 publications as books, journal articles, and conference papers. He has authored and/or edited around seventy books. Prof. Sarfraz is a member of various professional societies. He is a chair and member of international advisory committees and organizing committees of numerous international conferences. He is also an editor and editor in chief for various international journals.",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"32650",title:"Prof.",name:"Lukas",middleName:"Willem",surname:"Snyman",slug:"lukas-snyman",fullName:"Lukas Snyman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/32650/images/4136_n.jpg",biography:"Lukas Willem Snyman received his basic education at primary and high schools in South Africa, Eastern Cape. He enrolled at today's Nelson Metropolitan University and graduated from this university with a BSc in Physics and Mathematics, B.Sc Honors in Physics, MSc in Semiconductor Physics, and a Ph.D. in Semiconductor Physics in 1987. After his studies, he chose an academic career and devoted his energy to the teaching of physics to first, second, and third-year students. After positions as a lecturer at the University of Port Elizabeth, he accepted a position as Associate Professor at the University of Pretoria, South Africa.\r\n\r\nIn 1992, he motivates the concept of 'television and computer-based education” as means to reach large student numbers with only the best of teaching expertise and publishes an article on the concept in the SA Journal of Higher Education of 1993 (and later in 2003). The University of Pretoria subsequently approved a series of test projects on the concept with outreach to Mamelodi and Eerste Rust in 1993. In 1994, the University established a 'Unit for Telematic Education ' as a support section for multiple faculties at the University of Pretoria. In subsequent years, the concept of 'telematic education” subsequently becomes well established in academic circles in South Africa, grew in popularity, and is adopted by many universities and colleges throughout South Africa as a medium of enhancing education and training, as a method to reaching out to far out communities, and as a means to enhance study from the home environment.\r\n\r\nProfessor Snyman in subsequent years pursued research in semiconductor physics, semiconductor devices, microelectronics, and optoelectronics.\r\n\r\nIn 2000 he joined the TUT as a full professor. Here served for a period as head of the Department of Electronic Engineering. Here he makes contributions to solar energy development, microwave and optoelectronic device development, silicon photonics, as well as contributions to new mobile telecommunication systems and network planning in SA.\r\n\r\nCurrently, he teaches electronics and telecommunications at the TUT to audiences ranging from first-year students to Ph.D. level.\r\n\r\nFor his research in the field of 'Silicon Photonics” since 1990, he has published (as author and co-author) about thirty internationally reviewed articles in scientific journals, contributed to more than forty international conferences, about 25 South African provisional patents (as inventor and co-inventor), 8 PCT international patent applications until now. Of these, two USA patents applications, two European Patents, two Korean patents, and ten SA patents have been granted. A further 4 USA patents, 5 European patents, 3 Korean patents, 3 Chinese patents, and 3 Japanese patents are currently under consideration.\r\n\r\nRecently he has also published an extensive scholarly chapter in an internet open access book on 'Integrating Microphotonic Systems and MOEMS into standard Silicon CMOS Integrated circuitry”.\r\n\r\nFurthermore, Professor Snyman recently steered a new initiative at the TUT by introducing a 'Laboratory for Innovative Electronic Systems ' at the Department of Electrical Engineering. The model of this laboratory or center is to primarily combine outputs as achieved by high-level research with lower-level system development and entrepreneurship in a technical university environment. Students are allocated to projects at different levels with PhDs and Master students allocated to the generation of new knowledge and new technologies, while students at the diploma and Baccalaureus level are allocated to electronic systems development with a direct and a near application for application in industry or the commercial and public sectors in South Africa.\r\n\r\nProfessor Snyman received the WIRSAM Award of 1983 and the WIRSAM Award in 1985 in South Africa for best research papers by a young scientist at two international conferences on electron microscopy in South Africa. He subsequently received the SA Microelectronics Award for the best dissertation emanating from studies executed at a South African university in the field of Physics and Microelectronics in South Africa in 1987. In October of 2011, Professor Snyman received the prestigious Institutional Award for 'Innovator of the Year” for 2010 at the Tshwane University of Technology, South Africa. This award was based on the number of patents recognized and granted by local and international institutions as well as for his contributions concerning innovation at the TUT.",institutionString:null,institution:{name:"University of South Africa",country:{name:"South Africa"}}},{id:"317279",title:"Mr.",name:"Ali",middleName:"Usama",surname:"Syed",slug:"ali-syed",fullName:"Ali Syed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/317279/images/16024_n.png",biography:"A creative, talented, and innovative young professional who is dedicated, well organized, and capable research fellow with two years of experience in graduate-level research, published in engineering journals and book, with related expertise in Bio-robotics, equally passionate about the aesthetics of the mechanical and electronic system, obtained expertise in the use of MS Office, MATLAB, SolidWorks, LabVIEW, Proteus, Fusion 360, having a grasp on python, C++ and assembly language, possess proven ability in acquiring research grants, previous appointments with social and educational societies with experience in administration, current affiliations with IEEE and Web of Science, a confident presenter at conferences and teacher in classrooms, able to explain complex information to audiences of all levels.",institutionString:null,institution:{name:"Air University",country:{name:"Pakistan"}}},{id:"75526",title:"Ph.D.",name:"Zihni Onur",middleName:null,surname:"Uygun",slug:"zihni-onur-uygun",fullName:"Zihni Onur Uygun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/75526/images/12_n.jpg",biography:"My undergraduate education and my Master of Science educations at Ege University and at Çanakkale Onsekiz Mart University have given me a firm foundation in Biochemistry, Analytical Chemistry, Biosensors, Bioelectronics, Physical Chemistry and Medicine. After obtaining my degree as a MSc in analytical chemistry, I started working as a research assistant in Ege University Medical Faculty in 2014. In parallel, I enrolled to the MSc program at the Department of Medical Biochemistry at Ege University to gain deeper knowledge on medical and biochemical sciences as well as clinical chemistry in 2014. In my PhD I deeply researched on biosensors and bioelectronics and finished in 2020. Now I have eleven SCI-Expanded Index published papers, 6 international book chapters, referee assignments for different SCIE journals, one international patent pending, several international awards, projects and bursaries. In parallel to my research assistant position at Ege University Medical Faculty, Department of Medical Biochemistry, in April 2016, I also founded a Start-Up Company (Denosens Biotechnology LTD) by the support of The Scientific and Technological Research Council of Turkey. Currently, I am also working as a CEO in Denosens Biotechnology. The main purposes of the company, which carries out R&D as a research center, are to develop new generation biosensors and sensors for both point-of-care diagnostics; such as glucose, lactate, cholesterol and cancer biomarker detections. My specific experimental and instrumental skills are Biochemistry, Biosensor, Analytical Chemistry, Electrochemistry, Mobile phone based point-of-care diagnostic device, POCTs and Patient interface designs, HPLC, Tandem Mass Spectrometry, Spectrophotometry, ELISA.",institutionString:null,institution:{name:"Ege University",country:{name:"Turkey"}}},{id:"246502",title:"Dr.",name:"Jaya T.",middleName:"T",surname:"Varkey",slug:"jaya-t.-varkey",fullName:"Jaya T. Varkey",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246502/images/11160_n.jpg",biography:"Jaya T. Varkey, PhD, graduated with a degree in Chemistry from Cochin University of Science and Technology, Kerala, India. She obtained a PhD in Chemistry from the School of Chemical Sciences, Mahatma Gandhi University, Kerala, India, and completed a post-doctoral fellowship at the University of Minnesota, USA. She is a research guide at Mahatma Gandhi University and Associate Professor in Chemistry, St. Teresa’s College, Kochi, Kerala, India.\nDr. Varkey received a National Young Scientist award from the Indian Science Congress (1995), a UGC Research award (2016–2018), an Indian National Science Academy (INSA) Visiting Scientist award (2018–2019), and a Best Innovative Faculty award from the All India Association for Christian Higher Education (AIACHE) (2019). She Hashas received the Sr. Mary Cecil prize for best research paper three times. She was also awarded a start-up to develop a tea bag water filter. \nDr. Varkey has published two international books and twenty-seven international journal publications. She is an editorial board member for five international journals.",institutionString:"St. Teresa’s College",institution:null},{id:"250668",title:"Dr.",name:"Ali",middleName:null,surname:"Nabipour Chakoli",slug:"ali-nabipour-chakoli",fullName:"Ali Nabipour Chakoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/250668/images/system/250668.jpg",biography:"Academic Qualification:\r\n•\tPhD in Materials Physics and Chemistry, From: Sep. 2006, to: Sep. 2010, School of Materials Science and Engineering, Harbin Institute of Technology, Thesis: Structure and Shape Memory Effect of Functionalized MWCNTs/poly (L-lactide-co-ε-caprolactone) Nanocomposites. Supervisor: Prof. Wei Cai,\r\n•\tM.Sc in Applied Physics, From: 1996, to: 1998, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Determination of Boron in Micro alloy Steels with solid state nuclear track detectors by neutron induced auto radiography, Supervisors: Dr. M. Hosseini Ashrafi and Dr. A. Hosseini.\r\n•\tB.Sc. in Applied Physics, From: 1991, to: 1996, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Design of shielding for Am-Be neutron sources for In Vivo neutron activation analysis, Supervisor: Dr. M. Hosseini Ashrafi.\r\n\r\nResearch Experiences:\r\n1.\tNanomaterials, Carbon Nanotubes, Graphene: Synthesis, Functionalization and Characterization,\r\n2.\tMWCNTs/Polymer Composites: Fabrication and Characterization, \r\n3.\tShape Memory Polymers, Biodegradable Polymers, ORC, Collagen,\r\n4.\tMaterials Analysis and Characterizations: TEM, SEM, XPS, FT-IR, Raman, DSC, DMA, TGA, XRD, GPC, Fluoroscopy, \r\n5.\tInteraction of Radiation with Mater, Nuclear Safety and Security, NDT(RT),\r\n6.\tRadiation Detectors, Calibration (SSDL),\r\n7.\tCompleted IAEA e-learning Courses:\r\nNuclear Security (15 Modules),\r\nNuclear Safety:\r\nTSA 2: Regulatory Protection in Occupational Exposure,\r\nTips & Tricks: Radiation Protection in Radiography,\r\nSafety and Quality in Radiotherapy,\r\nCourse on Sealed Radioactive Sources,\r\nCourse on Fundamentals of Environmental Remediation,\r\nCourse on Planning for Environmental Remediation,\r\nKnowledge Management Orientation Course,\r\nFood Irradiation - Technology, Applications and Good Practices,\r\nEmployment:\r\nFrom 2010 to now: Academic staff, Nuclear Science and Technology Research Institute, Kargar Shomali, Tehran, Iran, P.O. Box: 14395-836.\r\nFrom 1997 to 2006: Expert of Materials Analysis and Characterization. Research Center of Agriculture and Medicine. Rajaeeshahr, Karaj, Iran, P. O. Box: 31585-498.",institutionString:"Atomic Energy Organization of Iran",institution:{name:"Atomic Energy Organization of Iran",country:{name:"Iran"}}},{id:"248279",title:"Dr.",name:"Monika",middleName:"Elzbieta",surname:"Machoy",slug:"monika-machoy",fullName:"Monika Machoy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248279/images/system/248279.jpeg",biography:"Monika Elżbieta Machoy, MD, graduated with distinction from the Faculty of Medicine and Dentistry at the Pomeranian Medical University in 2009, defended her PhD thesis with summa cum laude in 2016 and is currently employed as a researcher at the Department of Orthodontics of the Pomeranian Medical University. She expanded her professional knowledge during a one-year scholarship program at the Ernst Moritz Arndt University in Greifswald, Germany and during a three-year internship at the Technical University in Dresden, Germany. She has been a speaker at numerous orthodontic conferences, among others, American Association of Orthodontics, European Orthodontic Symposium and numerous conferences of the Polish Orthodontic Society. She conducts research focusing on the effect of orthodontic treatment on dental and periodontal tissues and the causes of pain in orthodontic patients.",institutionString:"Pomeranian Medical University",institution:{name:"Pomeranian Medical University",country:{name:"Poland"}}},{id:"252743",title:"Prof.",name:"Aswini",middleName:"Kumar",surname:"Kar",slug:"aswini-kar",fullName:"Aswini Kar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252743/images/10381_n.jpg",biography:"uploaded in cv",institutionString:null,institution:{name:"KIIT University",country:{name:"India"}}},{id:"204256",title:"Dr.",name:"Anil",middleName:"Kumar",surname:"Kumar Sahu",slug:"anil-kumar-sahu",fullName:"Anil Kumar Sahu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204256/images/14201_n.jpg",biography:"I have nearly 11 years of research and teaching experience. I have done my master degree from University Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur, Chhattisgarh India. I have published 16 review and research articles in international and national journals and published 4 chapters in IntechOpen, the world’s leading publisher of Open access books. I have presented many papers at national and international conferences. I have received research award from Indian Drug Manufacturers Association in year 2015. My research interest extends from novel lymphatic drug delivery systems, oral delivery system for herbal bioactive to formulation optimization.",institutionString:null,institution:{name:"Chhattisgarh Swami Vivekanand Technical University",country:{name:"India"}}},{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",biography:"An assistant professor at Department of Biomedical Computer Systems, at Institute of Computer Science, Silesian University in Katowice. Scientific interests: computer analysis and processing of images, biomedical images, databases and programming languages. He is an author and co-author of scientific publications covering analysis and processing of biomedical images and development of database systems.",institutionString:"University of Silesia",institution:null},{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",biography:"Dr. Hadi Mohammadi is a biomedical engineer with hands-on experience in the design and development of many engineering structures and medical devices through various projects that he has been involved in over the past twenty years. Dr. Mohammadi received his BSc. and MSc. degrees in Mechanical Engineering from Sharif University of Technology, Tehran, Iran, and his PhD. degree in Biomedical Engineering (biomaterials) from the University of Western Ontario. He was a postdoctoral trainee for almost four years at University of Calgary and Harvard Medical School. He is an industry innovator having created the technology to produce lifelike synthetic platforms that can be used for the simulation of almost all cardiovascular reconstructive surgeries. He’s been heavily involved in the design and development of cardiovascular devices and technology for the past 10 years. He is currently an Assistant Professor with the University of British Colombia, Canada.",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",country:{name:"Canada"}}},{id:"254463",title:"Prof.",name:"Haisheng",middleName:null,surname:"Yang",slug:"haisheng-yang",fullName:"Haisheng Yang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/254463/images/system/254463.jpeg",biography:"Haisheng Yang, Ph.D., Professor and Director of the Department of Biomedical Engineering, College of Life Science and Bioengineering, Beijing University of Technology. He received his Ph.D. degree in Mechanics/Biomechanics from Harbin Institute of Technology (jointly with University of California, Berkeley). Afterwards, he worked as a Postdoctoral Research Associate in the Purdue Musculoskeletal Biology and Mechanics Lab at the Department of Basic Medical Sciences, Purdue University, USA. He also conducted research in the Research Centre of Shriners Hospitals for Children-Canada at McGill University, Canada. Dr. Yang has over 10 years research experience in orthopaedic biomechanics and mechanobiology of bone adaptation and regeneration. He earned an award from Beijing Overseas Talents Aggregation program in 2017 and serves as Beijing Distinguished Professor.",institutionString:"Beijing University of Technology",institution:null},{id:"255757",title:"Dr.",name:"Igor",middleName:"Victorovich",surname:"Lakhno",slug:"igor-lakhno",fullName:"Igor Lakhno",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255757/images/system/255757.jpg",biography:"Lakhno Igor Victorovich was born in 1971 in Kharkiv (Ukraine). \nMD – 1994, Kharkiv National Medical Univesity.\nOb&Gyn; – 1997, master courses in Kharkiv Medical Academy of Postgraduate Education.\nPhD – 1999, Kharkiv National Medical Univesity.\nDSc – 2019, PL Shupik National Academy of Postgraduate Education \nLakhno Igor has been graduated from an international training courses on reproductive medicine and family planning held in Debrecen University (Hungary) in 1997. Since 1998 Lakhno Igor has worked as an associate professor of the department of obstetrics and gynecology of VN Karazin National University and an associate professor of the perinatology, obstetrics and gynecology department of Kharkiv Medical Academy of Postgraduate Education. Since June 2019 he’s a professor of the department of obstetrics and gynecology of VN Karazin National University and a professor of the perinatology, obstetrics and gynecology department of Kharkiv Medical Academy of Postgraduate Education . He’s an author of about 200 printed works and there are 17 of them in Scopus or Web of Science databases. Lakhno Igor is a rewiever of Journal of Obstetrics and Gynaecology (Taylor and Francis), Informatics in Medicine Unlocked (Elsevier), The Journal of Obstetrics and Gynecology Research (Wiley), Endocrine, Metabolic & Immune Disorders-Drug Targets (Bentham Open), The Open Biomedical Engineering Journal (Bentham Open), etc. He’s defended a dissertation for DSc degree \\'Pre-eclampsia: prediction, prevention and treatment”. Lakhno Igor has participated as a speaker in several international conferences and congresses (International Conference on Biological Oscillations April 10th-14th 2016, Lancaster, UK, The 9th conference of the European Study Group on Cardiovascular Oscillations). His main scientific interests: obstetrics, women’s health, fetal medicine, cardiovascular medicine.",institutionString:"V.N. Karazin Kharkiv National University",institution:{name:"Kharkiv Medical Academy of Postgraduate Education",country:{name:"Ukraine"}}},{id:"89721",title:"Dr.",name:"Mehmet",middleName:"Cuneyt",surname:"Ozmen",slug:"mehmet-ozmen",fullName:"Mehmet Ozmen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/89721/images/7289_n.jpg",biography:null,institutionString:null,institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"243698",title:"M.D.",name:"Xiaogang",middleName:null,surname:"Wang",slug:"xiaogang-wang",fullName:"Xiaogang Wang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243698/images/system/243698.png",biography:"Dr. Xiaogang Wang, a faculty member of Shanxi Eye Hospital specializing in the treatment of cataract and retinal disease and a tutor for postgraduate students of Shanxi Medical University, worked in the COOL Lab as an international visiting scholar under the supervision of Dr. David Huang and Yali Jia from October 2012 through November 2013. Dr. Wang earned an MD from Shanxi Medical University and a Ph.D. from Shanghai Jiao Tong University. Dr. Wang was awarded two research project grants focused on multimodal optical coherence tomography imaging and deep learning in cataract and retinal disease, from the National Natural Science Foundation of China. He has published around 30 peer-reviewed journal papers and four book chapters and co-edited one book.",institutionString:"Shanxi Eye Hospital",institution:{name:"Shanxi Eye Hospital",country:{name:"China"}}},{id:"242893",title:"Ph.D. Student",name:"Joaquim",middleName:null,surname:"De Moura",slug:"joaquim-de-moura",fullName:"Joaquim De Moura",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/242893/images/7133_n.jpg",biography:"Joaquim de Moura received his degree in Computer Engineering in 2014 from the University of A Coruña (Spain). In 2016, he received his M.Sc degree in Computer Engineering from the same university. He is currently pursuing his Ph.D degree in Computer Science in a collaborative project between ophthalmology centers in Galicia and the University of A Coruña. His research interests include computer vision, machine learning algorithms and analysis and medical imaging processing of various kinds.",institutionString:null,institution:{name:"University of A Coruña",country:{name:"Spain"}}},{id:"267434",title:"Dr.",name:"Rohit",middleName:null,surname:"Raja",slug:"rohit-raja",fullName:"Rohit Raja",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRZkkQAG/Profile_Picture_2022-05-09T12:55:18.jpg",biography:null,institutionString:null,institution:null},{id:"294334",title:"B.Sc.",name:"Marc",middleName:null,surname:"Bruggeman",slug:"marc-bruggeman",fullName:"Marc Bruggeman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/294334/images/8242_n.jpg",biography:"Chemical engineer graduate, with a passion for material science and specific interest in polymers - their near infinite applications intrigue me. \n\nI plan to continue my scientific career in the field of polymeric biomaterials as I am fascinated by intelligent, bioactive and biomimetic materials for use in both consumer and medical applications.",institutionString:null,institution:null},{id:"244950",title:"Dr.",name:"Salvatore",middleName:null,surname:"Di Lauro",slug:"salvatore-di-lauro",fullName:"Salvatore Di Lauro",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0030O00002bSF1HQAW/ProfilePicture%202021-12-20%2014%3A54%3A14.482",biography:"Name:\n\tSALVATORE DI LAURO\nAddress:\n\tHospital Clínico Universitario Valladolid\nAvda Ramón y Cajal 3\n47005, Valladolid\nSpain\nPhone number: \nFax\nE-mail:\n\t+34 983420000 ext 292\n+34 983420084\nsadilauro@live.it\nDate and place of Birth:\nID Number\nMedical Licence \nLanguages\t09-05-1985. Villaricca (Italy)\n\nY1281863H\n474707061\nItalian (native language)\nSpanish (read, written, spoken)\nEnglish (read, written, spoken)\nPortuguese (read, spoken)\nFrench (read)\n\t\t\nCurrent position (title and company)\tDate (Year)\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. Private practise.\t2017-today\n\n2019-today\n\t\n\t\nEducation (High school, university and postgraduate training > 3 months)\tDate (Year)\nDegree in Medicine and Surgery. University of Neaples 'Federico II”\nResident in Opthalmology. Hospital Clinico Universitario Valladolid\nMaster in Vitreo-Retina. IOBA. University of Valladolid\nFellow of the European Board of Ophthalmology. Paris\nMaster in Research in Ophthalmology. University of Valladolid\t2003-2009\n2012-2016\n2016-2017\n2016\n2012-2013\n\t\nEmployments (company and positions)\tDate (Year)\nResident in Ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl.\nFellow in Vitreo-Retina. IOBA. University of Valladolid\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. \n\t2012-2016\n2016-2017\n2017-today\n\n2019-Today\n\n\n\t\nClinical Research Experience (tasks and role)\tDate (Year)\nAssociated investigator\n\n' FIS PI20/00740: DESARROLLO DE UNA CALCULADORA DE RIESGO DE\nAPARICION DE RETINOPATIA DIABETICA BASADA EN TECNICAS DE IMAGEN MULTIMODAL EN PACIENTES DIABETICOS TIPO 1. Grant by: Ministerio de Ciencia e Innovacion \n\n' (BIO/VA23/14) Estudio clínico multicéntrico y prospectivo para validar dos\nbiomarcadores ubicados en los genes p53 y MDM2 en la predicción de los resultados funcionales de la cirugía del desprendimiento de retina regmatógeno. Grant by: Gerencia Regional de Salud de la Junta de Castilla y León.\n' Estudio multicéntrico, aleatorizado, con enmascaramiento doble, en 2 grupos\nparalelos y de 52 semanas de duración para comparar la eficacia, seguridad e inmunogenicidad de SOK583A1 respecto a Eylea® en pacientes con degeneración macular neovascular asociada a la edad' (CSOK583A12301; N.EUDRA: 2019-004838-41; FASE III). Grant by Hexal AG\n\n' Estudio de fase III, aleatorizado, doble ciego, con grupos paralelos, multicéntrico para comparar la eficacia y la seguridad de QL1205 frente a Lucentis® en pacientes con degeneración macular neovascular asociada a la edad. (EUDRACT: 2018-004486-13). Grant by Qilu Pharmaceutical Co\n\n' Estudio NEUTON: Ensayo clinico en fase IV para evaluar la eficacia de aflibercept en pacientes Naive con Edema MacUlar secundario a Oclusion de Vena CenTral de la Retina (OVCR) en regimen de tratamientO iNdividualizado Treat and Extend (TAE)”, (2014-000975-21). Grant by Fundacion Retinaplus\n\n' Evaluación de la seguridad y bioactividad de anillos de tensión capsular en conejo. Proyecto Procusens. Grant by AJL, S.A.\n\n'Estudio epidemiológico, prospectivo, multicéntrico y abierto\\npara valorar la frecuencia de la conjuntivitis adenovírica diagnosticada mediante el test AdenoPlus®\\nTest en pacientes enfermos de conjuntivitis aguda”\\n. National, multicenter study. Grant by: NICOX.\n\nEuropean multicentric trial: 'Evaluation of clinical outcomes following the use of Systane Hydration in patients with dry eye”. Study Phase 4. Grant by: Alcon Labs'\n\nVLPs Injection and Activation in a Rabbit Model of Uveal Melanoma. Grant by Aura Bioscience\n\nUpdating and characterization of a rabbit model of uveal melanoma. Grant by Aura Bioscience\n\nEnsayo clínico en fase IV para evaluar las variantes genéticas de la vía del VEGF como biomarcadores de eficacia del tratamiento con aflibercept en pacientes con degeneración macular asociada a la edad (DMAE) neovascular. Estudio BIOIMAGE. IMO-AFLI-2013-01\n\nEstudio In-Eye:Ensayo clínico en fase IV, abierto, aleatorizado, de 2 brazos,\nmulticçentrico y de 12 meses de duración, para evaluar la eficacia y seguridad de un régimen de PRN flexible individualizado de 'esperar y extender' versus un régimen PRN según criterios de estabilización mediante evaluaciones mensuales de inyecciones intravítreas de ranibizumab 0,5 mg en pacientes naive con neovascularización coriodea secunaria a la degeneración macular relacionada con la edad. CP: CRFB002AES03T\n\nTREND: Estudio Fase IIIb multicéntrico, randomizado, de 12 meses de\nseguimiento con evaluador de la agudeza visual enmascarado, para evaluar la eficacia y la seguridad de ranibizumab 0.5mg en un régimen de tratar y extender comparado con un régimen mensual, en pacientes con degeneración macular neovascular asociada a la edad. CP: CRFB002A2411 Código Eudra CT:\n2013-002626-23\n\n\n\nPublications\t\n\n2021\n\n\n\n\n2015\n\n\n\n\n2021\n\n\n\n\n\n2021\n\n\n\n\n2015\n\n\n\n\n2015\n\n\n2014\n\n\n\n\n2015-16\n\n\n\n2015\n\n\n2014\n\n\n2014\n\n\n\n\n2014\n\n\n\n\n\n\n\n2014\n\nJose Carlos Pastor; Jimena Rojas; Salvador Pastor-Idoate; Salvatore Di Lauro; Lucia Gonzalez-Buendia; Santiago Delgado-Tirado. Proliferative vitreoretinopathy: A new concept of disease pathogenesis and practical\nconsequences. Progress in Retinal and Eye Research. 51, pp. 125 - 155. 03/2016. DOI: 10.1016/j.preteyeres.2015.07.005\n\n\nLabrador-Velandia S; Alonso-Alonso ML; Di Lauro S; García-Gutierrez MT; Srivastava GK; Pastor JC; Fernandez-Bueno I. Mesenchymal stem cells provide paracrine neuroprotective resources that delay degeneration of co-cultured organotypic neuroretinal cultures.Experimental Eye Research. 185, 17/05/2019. DOI: 10.1016/j.exer.2019.05.011\n\nSalvatore Di Lauro; Maria Teresa Garcia Gutierrez; Ivan Fernandez Bueno. Quantification of pigment epithelium-derived factor (PEDF) in an ex vivo coculture of retinal pigment epithelium cells and neuroretina.\nJournal of Allbiosolution. 2019. ISSN 2605-3535\n\nSonia Labrador Velandia; Salvatore Di Lauro; Alonso-Alonso ML; Tabera Bartolomé S; Srivastava GK; Pastor JC; Fernandez-Bueno I. Biocompatibility of intravitreal injection of human mesenchymal stem cells in immunocompetent rabbits. Graefe's archive for clinical and experimental ophthalmology. 256 - 1, pp. 125 - 134. 01/2018. DOI: 10.1007/s00417-017-3842-3\n\n\nSalvatore Di Lauro, David Rodriguez-Crespo, Manuel J Gayoso, Maria T Garcia-Gutierrez, J Carlos Pastor, Girish K Srivastava, Ivan Fernandez-Bueno. A novel coculture model of porcine central neuroretina explants and retinal pigment epithelium cells. Molecular Vision. 2016 - 22, pp. 243 - 253. 01/2016.\n\nSalvatore Di Lauro. Classifications for Proliferative Vitreoretinopathy ({PVR}): An Analysis of Their Use in Publications over the Last 15 Years. Journal of Ophthalmology. 2016, pp. 1 - 6. 01/2016. DOI: 10.1155/2016/7807596\n\nSalvatore Di Lauro; Rosa Maria Coco; Rosa Maria Sanabria; Enrique Rodriguez de la Rua; Jose Carlos Pastor. Loss of Visual Acuity after Successful Surgery for Macula-On Rhegmatogenous Retinal Detachment in a Prospective Multicentre Study. Journal of Ophthalmology. 2015:821864, 2015. DOI: 10.1155/2015/821864\n\nIvan Fernandez-Bueno; Salvatore Di Lauro; Ivan Alvarez; Jose Carlos Lopez; Maria Teresa Garcia-Gutierrez; Itziar Fernandez; Eva Larra; Jose Carlos Pastor. Safety and Biocompatibility of a New High-Density Polyethylene-Based\nSpherical Integrated Porous Orbital Implant: An Experimental Study in Rabbits. Journal of Ophthalmology. 2015:904096, 2015. DOI: 10.1155/2015/904096\n\nPastor JC; Pastor-Idoate S; Rodríguez-Hernandez I; Rojas J; Fernandez I; Gonzalez-Buendia L; Di Lauro S; Gonzalez-Sarmiento R. Genetics of PVR and RD. Ophthalmologica. 232 - Suppl 1, pp. 28 - 29. 2014\n\nRodriguez-Crespo D; Di Lauro S; Singh AK; Garcia-Gutierrez MT; Garrosa M; Pastor JC; Fernandez-Bueno I; Srivastava GK. Triple-layered mixed co-culture model of RPE cells with neuroretina for evaluating the neuroprotective effects of adipose-MSCs. Cell Tissue Res. 358 - 3, pp. 705 - 716. 2014.\nDOI: 10.1007/s00441-014-1987-5\n\nCarlo De Werra; Salvatore Condurro; Salvatore Tramontano; Mario Perone; Ivana Donzelli; Salvatore Di Lauro; Massimo Di Giuseppe; Rosa Di Micco; Annalisa Pascariello; Antonio Pastore; Giorgio Diamantis; Giuseppe Galloro. Hydatid disease of the liver: thirty years of surgical experience.Chirurgia italiana. 59 - 5, pp. 611 - 636.\n(Italia): 2007. ISSN 0009-4773\n\nChapters in books\n\t\n' Salvador Pastor Idoate; Salvatore Di Lauro; Jose Carlos Pastor Jimeno. PVR: Pathogenesis, Histopathology and Classification. Proliferative Vitreoretinopathy with Small Gauge Vitrectomy. Springer, 2018. ISBN 978-3-319-78445-8\nDOI: 10.1007/978-3-319-78446-5_2. \n\n' Salvatore Di Lauro; Maria Isabel Lopez Galvez. Quistes vítreos en una mujer joven. Problemas diagnósticos en patología retinocoroidea. Sociedad Española de Retina-Vitreo. 2018.\n\n' Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor Jimeno. iOCT in PVR management. OCT Applications in Opthalmology. pp. 1 - 8. INTECH, 2018. DOI: 10.5772/intechopen.78774.\n\n' Rosa Coco Martin; Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor. amponadores, manipuladores y tinciones en la cirugía del traumatismo ocular.Trauma Ocular. Ponencia de la SEO 2018..\n\n' LOPEZ GALVEZ; DI LAURO; CRESPO. OCT angiografia y complicaciones retinianas de la diabetes. PONENCIA SEO 2021, CAPITULO 20. (España): 2021.\n\n' Múltiples desprendimientos neurosensoriales bilaterales en paciente joven. Enfermedades Degenerativas De Retina Y Coroides. SERV 04/2016. \n' González-Buendía L; Di Lauro S; Pastor-Idoate S; Pastor Jimeno JC. Vitreorretinopatía proliferante (VRP) e inflamación: LA INFLAMACIÓN in «INMUNOMODULADORES Y ANTIINFLAMATORIOS: MÁS ALLÁ DE LOS CORTICOIDES. 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