The information matrix of the MIAO.
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IntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\\n\\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
\\n\\nLaunching 2021
\\n\\nArtificial Intelligence, ISSN 2633-1403
\\n\\nVeterinary Medicine and Science, ISSN 2632-0517
\\n\\nBiochemistry, ISSN 2632-0983
\\n\\nBiomedical Engineering, ISSN 2631-5343
\\n\\nInfectious Diseases, ISSN 2631-6188
\\n\\nPhysiology (Coming Soon)
\\n\\nDentistry (Coming Soon)
\\n\\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\\n\\nNote: Edited in October 2021
\\n"}]',published:!0,mainMedia:{caption:"",originalUrl:"/media/original/132"}},components:[{type:"htmlEditorComponent",content:'With the desire to make book publishing more relevant for the digital age and offer innovative Open Access publishing options, we are thrilled to announce the launch of our new publishing format: IntechOpen Book Series.
\n\nDesigned to cover fast-moving research fields in rapidly expanding areas, our Book Series feature a Topic structure allowing us to present the most relevant sub-disciplines. Book Series are headed by Series Editors, and a team of Topic Editors supported by international Editorial Board members. Topics are always open for submissions, with an Annual Volume published each calendar year.
\n\nAfter a robust peer-review process, accepted works are published quickly, thanks to Online First, ensuring research is made available to the scientific community without delay.
\n\nOur innovative Book Series format brings you:
\n\nIntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\n\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
\n\nLaunching 2021
\n\nArtificial Intelligence, ISSN 2633-1403
\n\nVeterinary Medicine and Science, ISSN 2632-0517
\n\nBiochemistry, ISSN 2632-0983
\n\nBiomedical Engineering, ISSN 2631-5343
\n\nInfectious Diseases, ISSN 2631-6188
\n\nPhysiology (Coming Soon)
\n\nDentistry (Coming Soon)
\n\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\n\nNote: Edited in October 2021
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Dr. Santana de Oliveira co-directs doctoral and master\'s students at the Postgraduate Programs PPGBOT and BIONORTE in partnership with Dr. Eloisa Helena de Aguiar Andrade and Dr. Ely Simome Cashew Gurgel.',coeditorOneBiosketch:"A researcher in Organic Chemistry, Food Chemistry, and Botany, with over 500 publications, three books edited, 297 works indexed in WOS and SCOPUS, and 3380 total citations.\r\nDr. Andrade is an associated researcher for the Paraense Museum Emilio Goeldi and Adjunta, Teacher of the Postgraduate Programs in Chemistry, UFPA, PPG- in C. 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From 2010 to 2014, he worked on the chemistry of natural products at the Empresa Brasileira de Pesquisa Agropecuária (Embrapa), and from 2014 to 2018, he worked in the Postgraduate Program in Food Science and Technology at the Federal University of Pará, specifically with essential oils. Since 2020, he has been a researcher for the Institutional Training Program - PCI, at the institution Museu Paraense Emilio Goeldi, linked to the Ministério da Ciência, Tecnologia e Inovações of Brazil (MCTI), with studies focused on extraction, characterization chemistry, and applications of essential oils in several industrial segments, among them the food industry. Specifically, Dr. Oliveira has experience in engineering, food science and technology, pharmacology and drug discovery, medicinal chemistry, ethnopharmacology and ethnobotany, phytochemistry, methods of extraction of bioactive compounds, biotechnology of natural products, and allelopathy to find new natural herbicides to control invasive plants. He also has experience in the area of essential oil extraction using supercritical technology and conventional methods. Since 2020, he has supervised and co-supervised master’s and Ph.D. students in several graduate programs. 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For. She is currently Associate Researcher II at the Botany Coordination of the Museu Paraense Emílio Goeldi and Adjunct Professor III at the Faculty of Chemistry at the Federal University of Pará. Professor of the Graduate Programs in Chemistry, UFPA, PPG- in Biological C. - Tropical Botany, UFRA/MPEG and Graduate in Biodiversity Biotechnology - Bionorte Network. She is the coordinator of the Pole of the State of Pará, Graduate Program in Biodiversity and Biotechnology (PPG-BIONORTE/PA) of the Bionorte Network (2016-2020). Dr. Andrade is the author of more than 500 scientific contributions, including articles, event communications, book chapters, and books. 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To improve efficiency, the engineer must knew the heat input, the mass of fuel, the fuel analysis and the kW rating generation in order to determine the actual heat rate. After the actual heat rate calculated and understood, losses must be identified and understood. Good communication and teamwork between the engineer and staff within the TPP is essential to success [1-2].
In fact, the heat rate is defined in units of Btu /kWh (KJ / kWh) and is simply the amount of heat input into a system divided by the amount of power generated by of a system [1].
The calculation of the heat rate enable to inform us on the state of the TPP and help the engineer to take out the reasons of the degradation of the TPP heat rate in order to reach the better one recorded at the time of acceptance test when the equipment was new and the TPP was operated at optimum. Therefore, this TPP heat rate value is realistic and attainable for it has been achieved before [1-2].
The global efficiency of a TPP is tributary of a certain number of factors and mainly of the furnace efficiency. Otherwise, there is place to also notice that with regards to the turbine and the alternator that are facilities of big importance in the constitution of a TPP, the degradation of their respective efficiencies hardly takes place long-term of a manner appreciable and this by reason of the ageing of some of their organs as: stationary and mobile aubages usury; increase of the internal flights; usury of alternator insulations, etc.
The objective of this paper is to analyze the different losses of a TPP therefore to implant solutions in order to act in time and to improve its efficiency. Appropriate performance parameters can enable the performance engineer to either immediately correct performance or estimate when it would be cost effective to make corrections. In fact, the performance parameters measure how well a TPP produces electricity.
These actions or decisions are [1]:
Improve TPP operation;
Predictive maintenance;
Comparison of actual to expected performance;
Improved economic dispatch of TPP;
Reduce uncertainty in actual costs for better MW sales.
This paper can be loosely divided into five parts. First, we present the functionality of TPP. Second, we present the boiler and steam turbine efficiency calculations. In section 3, we present the methodology of the analysis based on the Objectives Oriented Project Planning (OOPP) method. In section 4, we present the results of the application of system analysis for determining the possible losses for the degradation of the TPP heat rate. The last section presents a conclusion about the advantages and inconveniences of the analysis presented of the TPP heat rate improvement.
Thermal power plant (TPP) is a power plant in which the prime mover is steam driven. Water is heated, turns into steam and spins a steam turbine which drives an electrical generator. After it passes through the turbine, the steam is condensed in a condenser. The greatest variation in the design of TPPs is due to the different fuel sources. Some prefer to use the term energy center because such facilities convert forms of heat energy into electrical energy [3-5].
In TPPs, mechanical power is produced by a heat engine which transforms thermal energy, often from combustion of a fuel, into rotational energy. Most TPPs produce steam, and these are sometimes called steam power plants. TPPs are classified by the type of fuel and the type of prime mover installed (Figure 1).
Functionality of a TPP.
The electric efficiency of a conventional TPP, considered as saleable energy produced at the plant busbars compared with the heating value of the fuel consumed, is typically 33 to 48% efficient, limited as all heat engines are by the laws of thermodynamics. The rest of the energy must leave the plant in the form of heat.
Since the efficiency of the plant is fundamentally limited by the ratio of the absolute temperatures of the steam at turbine input and output, efficiency improvements require use of higher temperature, and therefore higher pressure, steam.
This overheated steam drags the HP rotor (high pressure) of the turbine in rotation and relaxes to the exit of the HP body of the turbine, so it comes back again in the furnace to be until 540° after, it will be sent back to the MP body (intermediate pressure) then to the BP body (low pressure) of the turbine.
During these steps, the calorific energy is transformed in available mechanical energy on the turbine. Thus, this mechanical energy will be transmitted to the alternator, being a generator of alternating current, in the goal to produce the electric energy.
After the condensation, water will be transmitted thanks to pumps of extraction in the station of BP to be warmed progressively before being sent back to the furnace through the intermediary of the food pumps.
This warms progressive of water has for goal to increase the output of the furnace and to avoid all thermal constraints on its partitions. And this station of water is composed of a certain number of intersections that is nourished in steam of the three bodies of the turbine. Finally, the cycle reproduces indefinitely since steam and water circulate in a closed circuit.
During this cycle water recovers the calorific energy in the boiler that it restores at the time of its detente in the turbine as a mechanical energy to the rotor of the turbine. The rotor of the turbine being harnessed to the rotor excited of the alternator, the mechanical energy of the turbine is transformed then in electric energy in the alternator.
Turbine constitutes an evolution exploiting principal’s advantages of turbo machines: mass power and elevated volume power; improved efficiency by the multiplication of detente floors [6-8].
Indeed, a steam turbine is a thermal motor with external combustion, functioning according to the thermodynamic cycle Clausius-Rankine. This cycle is distinguished by the state change affecting the motor fluid that is the water steam (Figure 2).
Clausius-Rankine cycle.
The efficiency grows with the steam pressure and with the overheat temperature. However, the increase of these features is limited by the water content in steam in the end of detente.
Indeed, the detente curve can reach the saturation curve with formation of droplets that is harmful to the efficiency of the last floors of detente. The content in liquid water of the mixture must be limited to 15 or 20%. At the end, it is the condenser pressure that fixes the admissible limits of pressure and temperature.
The boiler is a steam generator that assures the spraying of water (Figure 3). At this level operates the transformation of the chemical energy in calorific energy by combustion of a mixture "air-fuel".
Figure 3 presents an example of a boiler in a TPP in Tunisia.
Example of a boiler of a TPP.
The boiler is composed by different elements:
The combustion room
It constitutes a surrounding wall of contiguous tubular bundles inside in the water circulates. It is in this combustion room the transformation of the chemical energy in calorific energy by combustion of a mixture "air-fuel". This calorific energy frees a quantity of heat that will be transmitted to water to produce the steam of water in a temperature and under a very determined pressure.
The economiser
It has for role to recover a part of calories remaining in the gases of combustion to increase the temperature of the feeding water what will have for effect the increase of the thermal output of the installation and the elevated thermal constraint suppression in the metal of the reservoir.
The ball of the boiler
To the exit of the economizer, the water of feeding goes up toward a reservoir situated in the part superior of the boiler called ball of the boiler that constitutes a surrounding wall in sheet metal in which is the liquid phase and the phase steam of the feeding water.
Superheater / Reheater
It is an intersection of heat constituted of tubular bundles re-serving the gases of combustion directly; therefore submissive to the most elevated temperatures of the combustion room. Steam coming from the ball is humid; it passes therefore in tubes of the heater where its temperature is raised to relatively constant pressure.
After having undergone a first detente in the high pressure body of the turbine, steam comes back to the generator of steam and enter in an intersection called primary reheater of temperature 330°C then it crosses the final re-heater of temperature 540°C, then it is sent toward the intermediate pressure body of the turbine. To the exit of the intermediate pressure body steam passes in the body low pressure of the turbine.
Burners
The burner is the most important component to light the natural gas fuel-oil. Le role of the burner is of creates a zone of ignition to the sufficient temperature to maintain the combustion and to provide the necessary air mixture. The boiler include seven floors each one is equipped of four burners.
A turbine is constituted of a rotor composed of a tree on which is fixed the dawns and a stator of composed of a structural cover of the stationary deflectors, generally organized of two parts according to an axial plan [9-12].
The turbine is composed of a segmented admission tore and a controlled exhaust divergent toward the condenser. The stationary deflector function is to assure all or one of the detente while forming a nozzles network and to modify the direction of the out-flow retiring of the previous floor.
A steam turbine is composed of one or several floors assuring each two functions:
The steam detente that corresponds to the conversion of the potential energy in kinetic energy;
The conversion of the kinetic energy in rotation couple of the machine by the mobile aubages.
The steam turbines are often classified in two big categories combined in the same machine:
Turbines to action in which the detente makes himself solely in the stationary aubages. They are well adapted to strong pressure floors and are better suitable to the debit regulation. Their construction is more expensive and their use for the first floors.
The jet-propelled turbines in which the detente is distributed between stationary and mobile aubages. The degree of reaction is defined by the distribution of the detente between aubages. They are better suitable to bass pressure floors and their cost is weaker.
The realization of turbines requires the recourse to greatly allied steels (Cr-Ni-Va) to resist the thermal, mechanical constraints (centrifugal force) and chemical (steam corrosion). The first two constraints limit the diameter and therefore the capable debit of the last floors. So dawns besides of one meter of length already put serious problems of realization. Besides, the radial heterogeneity of speeds imposes a variable impact of the dawn that present then a left shape whose machining is complex [9-12].
The principal favour of steam turbines is to be external combustion motors. Of this fact, all fuels (gas, fuel-oil, coal, vestigial, geothermal heat) can be supplied it with steam. The efficiency can reach some elevated values and reduced working expenses (specific consumption of 2300 kcal/kWh and 3400 kcal/kWh for gas turbines). The cost and the complexity of facilities are the most often reserved to the elevated power facilities. But in particular cases, motors and gas turbines are better adapted below about 10 MW.
Figure 4 presents an example of steam turbines in a TPP in Tunisia.
Disposition of steam turbines in a TPP.
In this paragraph, we present some methods used in order to determine the boiler efficiency and the steam turbine efficiency [13-15].
Among the multiple factors that can degrade the boiler efficiency, there is place to mention what follows as an example:
bad combustion following a bad working of the regulation;
bad quality of the fuel used;
heating inadequate of the used fuel;
flights of water and steam;
flights of air (comburant);
encrassement of the boiler;
encrassement of the air heating device…
Boiler efficiency can be calculated by one of two methods: the Input-Output method or the method of heat losses [1].
The expression of the boiler efficiency of the TPP is given by:
The exit is defined by the sum of heats absorbed by the used fluid (water-steam).
The entrance is defined by the total energy introduced in the boiler.
The boiler efficiency is given by the following expression:
Qeal : debit water (kg/h);
Qinjsh: debit water injection;
Qinjrh: debit of the water of steam (Kg/h).
Hsh: enthalpy of steam to the exit;
Hal: enthalpy of water in entrance economizer;
Hrh: enthalpy of water (kcal/kg).
Herh: enthalpy of water exit HP (kcal/kg).
Hinjrh: enthalpy of water (kcal/kg).
Fh1: superior calorific power of fuel used (kcal/kg);
Qf : debit fued (t/h);
Be : total of heat introduced.
The boiler efficiency is given by the following expression:
Fh : Total energy introduced in the boiler.
Cper: Sum of the calorific losses at the level of the boiler.
In the case of fuel, the total heat introduced in the boiler comes from fuel, of the air of combustion and the steam of atomization.
The calorific losses that one meets in a boiler are essentially owed to the heat carried away by the gases of combustion, to the presence of water in fuel as well as the existing humidity in the air of combustion.
The calculation of the efficiency of bodies of the turbine with the difference enthalpy method is very useful for the assessment of the cleaning degree of the steam course in the body of the turbine.
The efficiency of the turbine is defined as the report between the real difference enthalpy (DHIHP) and the isotropy difference enthalpy (DHIHP) of steam crossing the HP body.
For the BP body this method is not applicable because of the title of steam to the BP exit (humid steam).
The efficiency of the HP body (ηHP) is defined as follows [1]:
The real enthalpy difference in the HP body is given by:
Hvap: enthalpy of steam overheated admission HP turbine.
Herh: enthalpy of steam to overheat HP exit.
The difference isotropy enthalpy in the HP body is given by:
Hith: final enthalpy of steam overheated for an expansion isotropy (S= constant) of the admission until exit of the HP turbine.
In addition the indicated thermodynamic losses appear in the machine external energy losses provoked mainly by rubbings mechanical landings furniture and flights. The efficiency of the turbine must take into account these losses.
The efficiency of the turbine is:
While the volumetric efficiency (Rvol) is equal to:
g: debit of flight ; G: debit weight.
There are many methods that have been used to enhance participation in Information System (IS) planning and requirements analysis. We review some methods here because we think them to be fairly representative of the general kinds of methods in use. The methods include Delphi, focus groups, SADT (Structured Analysis Design Technique), multiple criteria decision-making (MCDM), total quality management (TQM) and OOPP method (Objectives Oriented Project Planning).
The objective of the Delphi method is to acquire and aggregate knowledge from multiple experts so that participants can find a consensus solution to a problem [16].
A second distinct method is focus groups (or focused group interviews). This method relies on team or group dynamics to generate as many ideas as possible. Focus groups been used for decades by marketing researchers to understand customer product preferences [17].
MCDM views requirements gathering and analysis as a problem requiring individual interviews [18]. Analysts using MCDM focus primarily on analysis of the collected data to reveal users’ requirements, rather than on resolving or negotiating ambiguities. The objective is to find an optimal solution for the problem of conflicting values and objectives, where the problem is modelled as a set of quantitative values requiring optimization.
TQM is a way to include the customer in development process, to improve product quality. In a TQM project, data gathering for customers needs, i.e., requirements elicitation may be done with QFD [19].
The SADT method represent attempts to apply the concept of focus groups specifically to information systems planning, eliciting data from groups of stakeholders or organizational teams [20]. They are characterized by their use of predetermined roles for group/team members and the use of graphically structured diagrams. SADT enables capturing of a proposed system’s functions and data flows among the functions.
The OOPP method, used in this survey, is considered like a tool of communication, analysis and scheduling of project, whatever is its nature, its situation, its complexity and its sensitivity [21-24].
In this part, we present the OOPP method that we use in order to determine the different losses of the TPP.
This method is used more and more by several financial backers (World Bank, Union European, bilateral Cooperation…). It is also used to take to terms of development projects, of cooperation (Germany, Canada, Belgium...) or other. It gave a good satisfaction at the time of its exploitation and several researches have been done very well to develop tools and to prove its strength for the scheduling of projects.
The descriptive documentation of the OOPP method, indicate that the logic of the OOPP method is not in principle limited not to a type of a determined problematic. Nevertheless, in practice the method is more appropriated to the following interventions: projects of the technical cooperation and projects of investments with economic and / or social objective.
The OOPP method which is also referred to Logical Framework Approach (LFA) is a structured meeting process. This approach is based on four essential steps: Problem Analysis, Objectives Analysis, Alternatives Analysis and Activities Planning. It seeks to identify the major current problems using cause-effect analysis and search for the best strategy to alleviate these identified problems [21-24].
The first step of “Problem Analysis” seeks to get consensus on the detailed aspects of the problem. The first procedure in problem analysis is brainstorming. All participants are invited to write their problem ideas on small cards. The participants may write as many cards as they wish. The participants group the cards or look for cause-effect relationship between the themes on the cards by arranging the cards to form a problem tree (Figure 5).
Problem tree of the OOPP method.
In the step of “Objectives Analysis” the problem statements are converted into objective statements and if possible into an objective tree (Figure 6). Just as the problem tree shows cause-effect relationships, the objective tree shows means-end relationships. The means-end relationships show the means by which the project can achieve the desired ends or future desirable conditions.
Objective tree of the OOPP method.
The objective tree usually shows the large number of possible strategies or means-end links that could contribute to a solution to the problem. Since there will be a limit to the resources that can be applied to the project, it is necessary for the participants to examine these alternatives and select the most promising strategy. This step is called “Alternatives Analysis”.
After selection of the decision criteria, these are applied in order to select one or more means-end chains to become the set of objectives that will form the project strategy.
After defining the objectives and specifying how they will be measured (Objectively Verifiable Indicators: OVIs) and where and how that information will be found (Means of Verification: MOVs) we get to the detailed planning phase: “Activities Planning”. We determine what activities are required to achieve each objective. It is tempting to say; always start at the situation analysis stage, and from there determine who are the stakeholders.
We present some studies of the OOPP method in IS planning that have been presented in various researches:
Researchers, Gu & al. [25] have presented an object-oriented approach to the development of a generative process planning system. The system consists of three functional modules: object-oriented product model module, object-oriented manufacturing facility model module, and object-oriented process planner.
Researcher, Hill [26] has question the appropriateness of highly structured strategic planning approaches in situations of complexity and change, using the Cambodian-German Health Project as a case study. He has demonstrated the limitations of these planning processes in complex situations of high uncertainty, with little reliable information and a rapidly changing environment.
Researchers, Peffers & al. [27] have used information theory to justify the use of a method to help managers better understand what new Information Technology applications and features will be most valued by users and why and apply this method in a case study involving the development of financial service applications for mobile devices.
Researchers, Killich & al. [28] have presented the experiences and results of the development and implementation of a software-tool for a SME-network in the German automotive supply chain industry. The tool called TeamUp enables the communication of experts as well as the coordination of discussion groups in order to make use of synergetic potentials.
The application of the OOPP method to the identification of activities of work stations is important. The management of a system is conditioned notably by ties between its Entities Activities (EA), being able to be according to their hierarchical Specific Objective level (SO), of Results (R), of Activities (TO), of Under-activities (S), of Tasks (T)... These ties are materialized in fact by exchanges of information (If) produced by certain activities and consumed by others. The restraint of these ties requires an extension of the method. This new extension permits to identify the manner to execute these activities and to manage the different phases of the system.
An effort has been provided in order to refine the OOPP method. The OOPP method has been spread and a new denomination MISDIP (Method of Specification, Development and Implementation of Project) was adopted. The MISDIP method adopts the OOPP analysis and the complete it to specify the system of organization, to specify the system of information, and to contribute to its development and implementation [29].
We defined the Method of Informational Analysis by Objectives (MIAO) [30] permitting to elaborate an information matrix that permits to analyze the informational exchange process between activities.
In fact, the identification and the analysis of the information exchanged by the activities indicate the dynamics and the communication between the elements of the system that we propose to study or to manage. So, an information matrix was defined. This matrix establishes a correlation between activities and their information. The information concerning an activity can be classified in two categories:
The imported information by an activity is supposed to be available: it is either produced by other activity of the system, or coming from outside;
The produced information by an activity reflects the state of this activity. This last information may be exploited by other activities of the project.
In fact, the information produced by an activity can be considered like a transformation of imported information by this activity.
In order to specify this information, we define an information matrix (Table 1) associated to OOPP analysis enabling to determine the relations between the activities or between the concerned structures, to identify the information sources and to determine the manner in which the information is exploited.
The information matrix of the MIAO.
To make sure of the quality of information system, we define some logic-functional rules reflecting the coherence, the reliability and the comprehensiveness of the analysis by an information matrix in which the rows are relating to activities and the columns to information.
In order to become the exploitation of the information matrix more comfortable, we define the Method of Representation of the Information by Objectives (MRIO) [31] inspiring of the SADT method (Structured Analysis Design Technique) and we define its tools.
In this part, we present the results of the system analysis of a TPP whose objective is to determine the possible reasons of the degradation of the TPP heat rate. In fact, all events that are appropriate (preventive or corrective maintenance, exploitation, in conformity of modification, related to working, work stops…) are consigned on GMAO in the TPP in order to constitute the historic and to permit the traceability. This historic has been consulted in the goal to bring a more for the possible problems research.
The objectives tree (presented in linear form) presents ten specific objectives enabling to lead the global objective (GO): TPP heat rate losses identified.
These specific objectives are: Boiler losses identified; Condensate/FW system losses identified; Circulating water system losses identified; Turbine losses identified; Steam conditions losses identified; Electrical auxiliary losses identified; Steam auxiliary losses identified; Fuel handling losses identified; Heat losses identified; Cycle isolation losses identified.
Table 2 presents the OOPP analysis of the TPP heat rate losses.
1 | \n\t\t\tGO | \n\t\t\tTPP heat rate losses identified | \n\t\t
2 | \n\t\t\tSO1 | \n\t\t\tBoiler losses identified | \n\t\t
3 | \n\t\t\tSO2 | \n\t\t\tCondensate/FW system losses identified | \n\t\t
4 | \n\t\t\tSO3 | \n\t\t\tCirculating water system losses identified | \n\t\t
5 | \n\t\t\tSO4 | \n\t\t\tTurbine losses identified | \n\t\t
6 | \n\t\t\tSO5 | \n\t\t\tSteam conditions losses identified | \n\t\t
7 | \n\t\t\tSO6 | \n\t\t\tElectrical auxiliary losses identified | \n\t\t
8 | \n\t\t\tSO7 | \n\t\t\tSteam auxiliary losses identified | \n\t\t
9 | \n\t\t\tSO8 | \n\t\t\tFuel handling losses identified | \n\t\t
10 | \n\t\t\tSO9 | \n\t\t\tHeat losses identified | \n\t\t
11 | \n\t\t\tSO10 | \n\t\t\tCycle isolation losses identified | \n\t\t
OOPP analysis.
The final production of the application of the OOPP method enabled us to answer clearly to the question « what? ». Then, we presented the different results of the OOPP analysis to enable us identifying the different losses at the level of the TPP and to improve the TPP heat rate.
Figures 7 presents the objectives analysis related to the losses at the level of the boiler.
Objective tree of the boiler losses.
For example, the result R1.1 is decomposed in three intermediary results: Quality of the fuel identified; Moisture in air identified; Tube leaks losses identified.
Figures 8 presents the objectives analysis related to the losses at the level of the steam turbine.
Objective tree of the Turbine losses.
Figures 9 presents the objectives analysis related to the losses at the level of the Electrical auxiliary.
Objective tree of the Electrical auxiliary losses.
Table 3 presents some performance parameters that measure how well the TPP is doing its job in producing electricity. Then, we present in the last column some corrections actions that should be made to improve thermodynamic efficiency and to improve TPP’s overall performance.
\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t||
Pressure steam of the admission turbine very high | \n\t\t\tInstrument error | \n\t\t\tTo verify with the redundant measures To compare with pressures in relation as (pressure exit over heater, ball) | \n\t\t\tTo calibrate instruments | \n\t\t
No consistency with the order point | \n\t\t\tTo verify if floodgates of control of the turbine are opened completely and the pressure remains even high: the coefficient of evaporation debit in the furnace is very low | \n\t\t\tTo verify the order point of the pressure entrance turbine; To see the regulation system | \n\t\t|
Temperature steam of the admission turbine very low | \n\t\t\tInstrument error | \n\t\t\tTo verify with the redundant measures To compare with temperatures in relation as the difference with the temperature steam admission turbine must be between 0 and 15°C | \n\t\t\tTo calibrate instruments | \n\t\t
Pressure stem admission turbine high | \n\t\t\tPressure steam SH is a performance parameter | \n\t\t\t\n\t\t | |
Debit injection SH | \n\t\t\tTo verify the debit of injection: the debit of injection is a performance parameter | \n\t\t\t\n\t\t | |
Encrassement of exchange surfaces SH | \n\t\t\tTest integrity of the furnace: factor of tube encrassement | \n\t\t\tTo eliminate the encrassement | \n\t\t|
Low excess of air | \n\t\t\tTo verify the excess of air: the excess of air is a performance parameter | \n\t\t\t\n\t\t | |
Order point low | \n\t\t\tTo verify the order point | \n\t\t\tTo increase the value of the order point | \n\t\t|
Debit injection SH very high | \n\t\t\tInstrument error | \n\t\t\tTo verify with the redundant measures ; To calculate the debit from the temperature entrance and exit heating | \n\t\t\tTo calibrate instruments | \n\t\t
Order point of steam temperature very low | \n\t\t\tTo verify the order point steam temperature | \n\t\t\tTo increase the value of the order point | \n\t\t|
Debit injection on manual order point very high | \n\t\t\tTo see system of regulation | \n\t\t\tTo adjust the station of control of injection debit | \n\t\t|
Very high air excess | \n\t\t\tTo verify the excess of air: (performance parameter) | \n\t\t\t\n\t\t | |
Low water temperature: | \n\t\t\t\n\t\t\t | \n\t\t | |
a- by-pass HP heating | \n\t\t\tTo verify temperature water before and after by-pass HP | \n\t\t\tTo close floodgate by-pass HP heating device To eliminate the flights | \n\t\t|
B High TD heating HP | \n\t\t\tTo verify TD heating HP : (performance parameter) | \n\t\t\t\n\t\t | |
Very low pressure steam admission turbine | \n\t\t\tTo verify pressure steam admission turbine | \n\t\t\t\n\t\t | |
Flight floodgate control of injection | \n\t\t\tTo close the floodgate of insulation ; To verify if the conduct is hot | \n\t\t\tTo repair the floodgate | \n\t\t|
Debit injection RH very high | \n\t\t\tInstrument error | \n\t\t\tTo calculate the debit of steam from the temperature of entrance and exit | \n\t\t\t\n\t\t |
Very low order point of temperature steam | \n\t\t\tTo verify the order point | \n\t\t\tTo increase the value of the order point | \n\t\t|
Very high debit injection on manual order point | \n\t\t\tTo verify the control station | \n\t\t\tTo adjust the control station | \n\t\t|
Very high air excess | \n\t\t\tTo verify the air excess (performance parameter) | \n\t\t\t\n\t\t | |
Low water temperature: | \n\t\t\t\n\t\t\t | \n\t\t | |
a- by-pass heating HP | \n\t\t\tTo verify temperature water before and after by-pass HP | \n\t\t\tTo close floodgate by-pass HP heating ; To eliminate the flights | \n\t\t|
B High TD heating HP | \n\t\t\tTo verify TD heating HP : (performance parameter) | \n\t\t\t\n\t\t | |
Very low pressure steam admission turbine | \n\t\t\tTo verify pressure steam admission turbine | \n\t\t\t\n\t\t | |
Flight floodgate control of injection | \n\t\t\tTo close the floodgate of insulation ; To verify if the conduct is hot | \n\t\t\tTo repair the floodgate | \n\t\t|
Very low temperature vapeur admission turbine | \n\t\t\tTo verify temperature steam admission turbine | \n\t\t\t\n\t\t | |
Very low efficiency HP turbine | \n\t\t\tTo verify the efficiency of the HP turbine | \n\t\t\t\n\t\t |
Diagnosis of performance parameters and corrective actions.
The performance of a TPP will begin to decline as the thermal power plant (TPP) begins to age. A good performance program will be able to identify these losses of the degradation of the heat rate. A more accurate knowledge of TPP heat rates can improve economic dispatching costs and ensure that profits are maintained on a daily basis.
In fact, the performance parameters measure how well the TPP is doing its job in producing electricity. Decisions should not necessarily be made only to improve thermodynamic efficiency, but rather to improve TPP’s overall performance.
In this paper, we presented an exploration of the ways permitting the improvement of the TPP heat rate. This is why we presented a practical case of a TPP in Tunisia. The objective is to determine the possible causes generating losses and provoking the degradation of the TPP heat rate while using a system analysis method.
To reach this objective, System Analysis methods seem to be a promising way because the major advantage of these kinds of methods is due to the concept of hierarchy activity. These methods permit the complexity of a system to be overcome. In this paper, the application of the OOPP method on a real system, a thermal power plant in Tunisia generates a source of useful information for determining of the possible losses at the level of a TPP. So, research into the application of System Analysis methods must be intensified in order to solve several difficulties and to improve their efficiency.
The outbreak of Coronavirus Disease 2019 (COVID-19) has created a global public health crisis. Observational studies provided evidence that serum 25-hydroxyvitamin D [25(OH)D] concentration was inversely correlated with the incidence or severity of COVID-19 [1]. Moreover, very severe vitamin D deficiency (<10 ng/ml) was considerably more common in COVID-19 patients than in non-COVID-19 ones [2]. Consistently, a significant correlation between vitamin D sufficiency and reduction in clinical severity and inpatient mortality from COVID-19 disease has been explored [3, 4].
Actually, as vitamin D is concerned, traditional Chinese medicine (TCM) and Western medicine could share similar philosophical logic to fight against COVID-19, mainly because in TCM theory, the pathogenesis of COVID-19 is closely associated with cold dampness, which could be attenuated by sun exposure and Wen-Yang herbs, both of which could restore the blood level of vitamin D in Western medicine [5]. Clinically, TCM medications have been exhibiting benefits in decreasing the rate of disease progression, time to the resolution of fever, and rate of progression to severe COVID-19 cases [6], and we published a review summarizing the pharmacological interventions and the underlying mechanisms of TCM for organ injuries associated with COVID-19 [7].
As we know, the renal 1α-OHase enzyme catalyzes the biosynthesis of active vitamin D, 1,25(OH)2D3, and conversely, the 24-OHase enzyme in the kidney deactivates vitamin D via hydroxylation at site 24 on the chemical structure of 25(OH)D and 1,25(OH)2D3. In our group, we have published a series of research articles uncovering that the kidney-tonifying herb Fructus Ligustri Lucidi could manage vitamin D metabolism and enhance circulating 1,25(OH)2D3 level [8, 9, 10]. Intriguingly, there are TCM theories supporting the relevance between kidney and brain, such as “Interaction between Kidney and Brain,” and “Kidney dominates bone, and dredges brain,”
Several previous studies have demonstrated that the risk of COVID-19 and associated death increases with the coexistence of various underlying diseases, including liver and kidney failure, cerebrovascular disease, chronic obstructive pulmonary disease, coronary heart disease, hypertension, diabetes, and so forth [11, 12, 13, 14, 15, 16]. Among those comorbid diseases, the incidence of kidney injuries in the general population after infection with SARS-CoV-2 was around 3–15%, 14.5–50% in patients with severe COVID-19 infection in the intensive care unit, and even higher in patients with chronic kidney disease (CKD), which is related to severe infection and higher fatality rate in COVID-19 patients [17, 18]. In a retrospective case-control study from a Los Angeles Health System, Chang
A growing body of evidence suggests that vitamin D and COVID-19 are linked. The first study to examine whether the last vitamin D status before COVID-19 testing is associated with COVID-19 test results of 489 patients was published after the outbreak of the COVID-19 pandemic. This single-center retrospective cohort study concluded that adults with hypovitaminosis D were more likely to be infected by SARS-CoV-2 [21]. Similarly, in 20 European countries, substantial inverse associations between mean blood 25(OH)D concentrations and the frequency of COVID-19 cases and mortality were discovered [22]. The above data illustrate the close correlation between serum vitamin D levels and the risk rate of developing COVID-19. In addition, at the same time, studies found that vitamin D supplementation could reduce the risk of being infected with SARS-CoV-2. As presented in a retrospective cohort study done in Switzerland, vitamin D supplementation reduced the probability of SARS-CoV-2 infections [23]. Furthermore, frequent vitamin D3 supplementation, at least in the elderly, in boluses taken routinely throughout the year preceding diagnosis, has indicated a reduction in the risk of mortality and clinical improvement in old COVID-19 patients [24]. In a short term, randomized, placebo-controlled trial in 25(OH)D deficient (<20 ng/mL) COVID-19 individuals from India, 62.5% of those treated with 60,000 IU/1500 μg/day of vitamin D3 for 7–14 days were negative for SARS-CoV-2 after 21 days, compared with just 20.8% of those who were not given vitamin D3 [25].
Vitamin D is a vital protector for inhibiting inflammation and cytokine storms in the kidney [26]. The correlations were demonstrated between low vitamin D levels and the risk of influenza infection. Same as influenza, different studies showed that vitamin D status could influence the outcome of COVID-19 patients, including kidney injuries [27]. In Spain, a retrospective cohort clinical trial was held to compare whether the administration or not of oral calcifediol could alleviate mortality risk and the underlying diseases arising from COVID-19 [24]. Among the 537 included COVID-19 patients, those who received calcifediol (0.266 mg/capsule, two capsules on entry, and then one capsule on days 3, 7, 14, 21, and 28) were more likely to have a low rate of CKD and even mortality [24]. The COVID-19 patients accompanied by CKD with maintenance hemodialysis have a very high 3-month mortality rate, but researchers found that the same type of patient treated with active vitamin D had a lower risk of mortality caused by COVID-19 [28]. The facts all indicated that either serum vitamin D status or vitamin D supplementation has a strong link with the degree of severity of kidney injuries associated with COVID-19.
SARS-CoV-2 enters cells when its spike proteins are bound to angiotensin-converting enzyme 2 (ACE2) receptors, which are the potent negative regulators on the RAS and are highly expressed in the kidney [7]. The excess activity of the renal RAS, characterized as the increased production of angiotensin II (Ang II), is responsible for kidney destruction, inflammation, and functional failure related to SARS-CoV-2 [29].
Vitamin D inhibits renin expression and in turn reduces Ang II expression, thus, serving as a negative RAS regulator [29, 30]. The deficiency of vitamin D activates the intrarenal RAS, thereby inducing an increase in the level of Ang II, which is an important stimulator of kidney injury [31, 32]. Our study demonstrated that active vitamin D analogs paricalcitol and doxercalciferol were able to suppress RAS activation, alleviate glomerular and tubulointerstitial damage, and reduce proteinuria in streptozotocin (STZ, 40 mg/kg)-induced diabetic DBA/2 J mice [33, 34]. Similarly, treatment of STZ (60 mg/kg)-induced type 1 diabetic rats with calcitriol (0.2 μg/kg, i.g.) significantly reduced urine albumin and improved glomerular ultrastructure by reducing the renin expression and alleviating the oxidative stress of the kidneys [35]. The role of RAS in the kidney of type 2 diabetic mice (db/db mice) in our study was consistent with those studies performed on the type 1 diabetic animal models [36, 37]. As vitamin D exerts a vital effect by binding to vitamin D receptor (VDR), which is widely expressed in various organs and tissues including kidneys, we considered that VDR signaling may be a paramount modulator in the process of kidney injuries and therefore constructed the VDR knockout mice and performed a series of systematic studies. At first, our study found a significant elevation in renin gene expression in VDR-null mice [38, 39]. In
In line with the
Collectively, vitamin D might prevent kidney injury associated with SARS-CoV-2 infection by attenuating renal RAS as shown by an upregulation of ACE2 expression and downregulation of renin expression as well as a reduction in the production of Ang II locally in the kidney.
Researchers supported that in addition to the RAS imbalance caused by SARS-CoV-2 infection, the COVID-19 may also bring about the EMT, which has been reported as a major mechanism responsible for the abnormal accumulation of extracellular matrix (ECM). As reported, the accumulation of proteins and fibroblasts in ECM is a predominant factor in causing most kidney diseases [29]. It is believed that vitamin D could prevent kidney fibrosis by repressing the process of EMT [29].
As shown in recent research, calcitriol and paricalcitol (at equivalent doses of 1000 IU/kg) prevented the renal fibrosis in the 7/8 nephrectomy model within 4 weeks of treatment through the inhibition of EMT characterized by the changes of E-cadherin and Snail [43]. Similarly, type I and type III collagen, fibronectin, α-smooth muscle actin, and E-cadherin, which are the typical markers of EMT, were significantly regulated in UUO mice treated with paricalcitol, which therefore ameliorated renal interstitial fibrosis and preserved tubular epithelial integrity in obstructive nephropathy [44]. Furthermore, the
Overall, EMT might be one of the key pathogenic pathways for COVID-19-induced kidney injury, and the inhibition of EMT by vitamin D analogs suggests that it may ameliorate renal injury
As mentioned earlier, vitamin D is not only an essential factor for modulating real RAS and suppressing the EMT process, but also for regulating oxidative stress and inhibiting inflammation and cytokine storm, consequently reducing COVID-19-induced kidney damage [26]. The SARS-CoV-2 infection triggers the massive production of reactive oxygen species (ROS) and promotes oxidative damage. Jain
Low 25(OH)D status in COVID-19 patients was correlated with high levels of interleukin-6 (IL-6) and C-reactive protein (CRP), which are the independently inflammatory markers. Furthermore, the COVID-19 patients with insufficient 25(OH)D content may exert a high incidence of inflammation-induced renal injury [51]. Several experimental studies have reported that the administration of VDR activators reduced the presence of inflammatory cells in the kidney, thereby suppressing inflammatory responses and cytokine storms [7, 52, 53, 54]. Additionally, vitamin D intervention could decrease the production of inflammatory cytokines such as IL-6, IL-8, IL-12, IL-17, tumor necrosis factor-α (TNF-α), and interferons-γ (IFN-γ), and thus prevent inflammation from progressing and damaging other organs, including the kidneys [55, 56, 57]. As a result, numerous preclinical studies have been conducted using vitamin D as a treatment for various types of AKI, such as sepsis-induced AKI, with promising results in mitigating both renal oxidative stress and the expression of inflammatory cytokines in kidney [58].
Therefore, vitamin D could have the potential in diminishing the cytokine storm caused by COVID-19 and could exert protective effects against kidney injury.
The active vitamin D molecule 1,25(OH)2D3 could be produced in the kidneys and in extrarenal tissues such as activated monocytes/macrophages, where VDR is also expressed and is therefore vitamin D targets as well [59, 60]. Various studies have shown a stimulatory effect of vitamin D on Tregs (CD4+, CD25+, CD127−, FoxP3+), which are the important immune response cells in humans [61, 62, 63].
In detail, a study by Yuan
Since SARS-CoV-2 infection affects the immune system first and foremost, vitamin D intervention could somehow regulate the body’s immune function and the stress of immune cells in the kidney. Hence, it could be assumed that the modulations on the immune response might be one potential mechanism for the beneficial effects of vitamin D on kidney deterioration.
As the current understanding of COVID-19 continues to evolve, accumulating evidence demonstrated the neurological impact of this novel virus [70], particularly, the term “NeuroCovid” has been proposed in 2020 [71]. During the acute phase of COVID-19, about 36% of cases developed neurological symptoms of which 25% could be attributed to the direct involvement of the central nervous system (CNS) [72]. Patients with neurological deficits such as Parkinson’s disease (PD) did not exhibit an elevation in COVID-19 risk and mortality compared with the general population [73, 74]; however, COVID-19 might lead to the medium- and long-term consequences on CNS with neurodegenerative and neuropsychiatric diseases manifested as depression, insomnia, cognitive decline, accelerated aging, Parkinson’s disease (PD), or Alzheimer’s disease [71, 75]. The infection with SARS-CoV-2 even aggravates the CNS disorders and neurological complications of COVID-19 patients with preexisting neurological injury. In children with multiple sclerosis, the results of the web-based survey showed high anxiety levels during the pandemic [76]. Additionally, the affected patients associated with cognitive deficits might be at higher risk of cognitive decline after overcoming the COVID-19 infection [70]. Importantly, a systematic review of studies reporting data on PD patients with a diagnosis of COVID-19 indicated a higher case fatality in PD patients affected by COVID-19 than the general population [74]. Therefore, a strengthened awareness of the possibility of neurological involvement and a further investigation into the relevant pathophysiology would be essential to understand and ultimately abrogate SARS-CoV-2-related neurological symptoms [77].
An unselected large cohort study from Italy showed that the nonadvanced PD patients without vitamin D supplementation were more likely to be infected [73], and a retrospective survey from Spain elucidated that lower blood level of vitamin D was one of the main factors for developing COVID-19 in children with neuroimmunological disorders [78]. Consistently the systematic analysis including 16 studies reporting on a total of 11,325 PD patients suggested vitamin D might be a key protective factor against this infection [74], and the meta-analysis indicated the close correlation of vitamin D supplementation with COVID-19 in people with PD [79]. Furthermore, an early study using a multivariate general linear model found that a low serum level of 25(OH)D could predict an increased vulnerability to the stressful impact of the COVID-19 outbreak [80]. Collectively, vitamin D deficiency in circulation not only increases susceptibility to COVID-19 in patients with CNS disorders but also accelerates or aggravates preexisting neurodegenerative disease in COVID-19 patients.
Most of the emerging clinical results supported the beneficial effects of vitamin D supplements or therapy on neurological complications in COVID-19 patients, in accordance with the neuroprotective effects of vitamin D and its analogs. It is well elucidated that SARS-CoV-2 is a neuroinvasive virus capable of eliciting a cytokine storm, with persistent effects in specific populations. The impact of SARS-CoV-2 infection on the onset and progression of neurological diseases of neuroinflammatory origin is regarded as the potential cause of a delayed pandemic [81]. Remarkably, as a nonclassical role beyond action on skeletal homeostasis, the pharmacological regulations of vitamin D on inflammation responses including neuroinflammation have been widely studied. An interesting review stated that vitamin D could partially produce positive effects on the development of brain function for infants of mothers who experienced viral infections in early pregnancy by reducing some pro-inflammatory cytokines [82]. Vitamin D might act as a strong immunosuppressant repressing cytokine release syndrome in COVID-19 via attenuating the production and secretion of crucial pro-inflammatory cytokines including NF-kB, IL-6, IL-1β, and TNF [83]. One recent review implicated that the immunomodulatory effects of vitamin D significantly reduced the level of pro-inflammatory interleukins and enhanced the synthesis of anti-inflammatory chemical mediators [84]. Taken together, supplementation with vitamin D could be an effective option to avoid the development and progression of neurodegenerative pathologies in post-COVID-19 patients.
Given the extrarenal regulation of vitamin D on tissue function, its extrarenal metabolism, especially in CNS, will be extremely concerned in the research studies on neurological illnesses accompanied by COVID-19. Experimental data showed that VDR is expressed in CNS such as neurons and microglia, and 25(OH)D3 could be directly metabolized to 1,25(OH)2D3 due to the local presence of 1α-hydroxylase, implying a potential modulation of vitamin D in CNS in an autocrine or paracrine fashion. 1,25(OH)2D3 could stimulate the expression of glial cell line–derived neurotrophic factor, nerve growth factor, and neurotrophins-like nerve growth factor (NGF), thereby preventing loss of neural sensation in COVID-19 [83]. Moreover, 1,25(OH)2D3 could promote the expression of brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT3), and neurotrophin receptor p75NTR in neurons, glial cells, and Schwann cells [83], as well as induce the migration and differentiation of oligodendrocyte progenitors and enhance remyelination of neurons to improve neurotransmission in a model of toxic demyelination [85]. Additionally, it improved serotoninergic and dopaminergic neurotransmission in cultured neuronal cells by modulating serotonin and dopamine metabolism [86]. These effects account for the potential therapeutic efficacy of vitamin D on COVID-19-derived neuropsychiatric disorders [84].
Considering our previous work emphasized the role of RAS in the development of tissue injuries and the inhibitory effects of vitamin D on overactivity of tissue RAS, we attempted to uncover the underlying molecular mechanisms involved in the protection of vitamin D in COVID-19 patients from CNS damages on the aspect of brain RAS, which has been proposed five decades ago [87]. Human studies on the postmortem brain revealed that human coronavirus variants and SARS-CoV-2 could infect neurons and glia, demonstrating that SARS-CoV-2 may have similar neurovirulence [77]. In fact, the SARS-CoV-2 virus could use the ACE2 to cross the blood-brain barrier and invade neuronal and glial cells, as the studies have explored that SARS-CoV-2 has a high affinity for its receptor, the ACE2 protein [84, 88]. Furthermore, the research data showed the expression of ACE2 in neuronal and glial cells [89], which are also potentially vulnerable to SARS-CoV-2 infection. Attractively, a few studies have demonstrated the existence of RAS components in the basal ganglia, and particularly in the nigrostriatal system [90], even in mitochondria of dopaminergic neurons [91], though there are still controversial opinions about the presence of brain RAS as the angiotensin generation in the brain is concerned [87, 92].
It is well defined that there are two counterregulatory arms within RAS, namely the classical axis ACE/Ang II/AT1R and the newly emerged axis ACE2/Ang(1–7)/Mas [93]. The identification of the ACE homolog, ACE2 as a key Ang(1–7)-forming enzyme, unravels the existence of a distinct enzymatic pathway for the production of Ang(1–7), which has a broad range of effects in different organs and tissues that goes beyond its initially described cardiovascular and renal actions [94]. The decline in ACE2 expression that occurs with aging has been associated with higher morbidity and mortality rates in older adults [95]. Furthermore, numerous studies discovered that the cross talk and the interaction between the dual-axis systems of RAS contribute to tissue homeostasis. Our research project entitled “Biological effect of the double axes within RAS, ACE/Ang II/AT1R and ACE2/Ang(1-7)/Mas, in bone metabolism disturbance induced by high glucose and intervention study of active components in kidney-tonifying TCM,” funded by National Natural Science Foundation of China, illustrated that the two axes distinctly regulated the differentiation and functions of osteoblasts and osteoclasts upon exposure to high glucose [96]. Our study [96] and another study [97] support the concept that the ACE2/Ang(1–7)/Mas axis is able to counteract most of the deleterious actions of the ACE/Ang II/AT1R axis, especially in pathological conditions. Thus, we suppose that the interfering of SARS-CoV-2 with ACE2 in the brain would lead to a disturbance between the two axes and, in turn, produce deleterious effects in CNS observed in infected patients.
In vivo and in vitro studies clarified a counterregulatory interaction between dopamine and angiotensin receptors [98] and between SIRT3 and angiotensin receptors [99] in the striatum and substantia nigra, especially in an age-dependent manner, thereafter induced dopaminergic function injury accounting for the rise in the risk of neurodegenerative diseases, such as PD. Besides that, the hyperactivation of the ACE/Ang II/AT1R axis could exacerbate dopaminergic cell death, the animal study explicated that the Ang(1–7)/Mas axis possessed a neuroprotective role in the dopaminergic system, and in turn, ameliorated aging-related vulnerability to neurodegeneration [100].
Vitamin D could raise the bioavailability and upregulate the expression of ACE2, which may be responsible for trapping and inactivating SARS-CoV-2 [101, 102]. Importantly, vitamin D could mitigate the RAS-activation-evoked tissue destruction by serving as an RAS inhibitor. The overall effects of vitamin D on brain RAS are assumed as a drop-in Ang II level and a rise in Ang(1–7) level by inducing the ACE2/Ang(1–7)/Mas axis activity and suppressing ACE/Ang II/AT1R axis [88, 103]. Our research articles have reported that active vitamin D analog paricalcitol could dramatically improve LPS-induced depressive-like behavior of mice by abolishing neuroinflammation via diminishing RAS activity in the hypothalamus [104], and the kidney-tonifying traditional herb Fructus Ligustri Lucidi displayed the suppressive effects on levels of pro-inflammatory cytokines by improving vitamin D metabolism [105]. Consistent with these findings, vitamin D supplementation appeared to reverse COVID-19-related neurodegeneration and neuroinflammation, which are aggravated in Parkinson’s and Alzheimer’s patients [95]. These pieces of evidence heighten the key role of vitamin D as a neuroprotective and neuroreparative agent against the neurological sequelae of COVID-19.
Taken together, the mechanism studies revealed the crucial role of VDR in the protection of nephropathy through regulating multiple biological events (Figure 1) and that vitamin D exerted neuroprotective effects by balancing RAS in CNS (Figure 2), thereby vitamin D and its analogs possess the high potential in the protection and treatment of kidney and CNS disorders associated with COVID-19.
Vitamin D displayed nephroprotective effects through regulating multiple biological events.
Vitamin D exerted neuroprotective effects
This chapter was supported in part by National Natural Science Foundation of China (82074468), Scientific and Innovative Action Plan from Science and Technology Commission of Shanghai Municipality (21400760400), National Key R&D Program (2018YFC1704302) and Program for Innovative Research Team (2015RA4002) from Ministry of Science and Technology of China, and Shanghai Collaborative Innovation Center of Industrial Transformation of Hospital TCM Preparation.
The authors declare no conflict of interest.
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\\n\\nThe Corresponding Author shall obtain written informed consent for publication from people who might recognize themselves or be identified by others (e.g. from case reports or photographs).
\\n\\n3.4 The Corresponding Author and any Co-Author shall respect confidentiality rights during and after the termination of this Agreement. The information contained in all correspondence and documents as part of the publishing activity between IntechOpen and the Corresponding Author and any Co-Author are confidential and are intended only for the recipient. The contents may not be disclosed publicly and are not intended for unauthorized use or distribution. Any use, disclosure, copying, or distribution is prohibited and may be unlawful.
\\n\\n4. CORRESPONDING AUTHOR'S WARRANTY
\\n\\n4.1 The Corresponding Author represents and warrants that the Article does not and will not breach any applicable law or the rights of any third party and, specifically, that the Article contains no matter that is defamatory or that infringes any literary or proprietary rights, intellectual property rights, or any rights of privacy. The Corresponding Author warrants and represents that: (i) the Article is the original work of themselves and any Co-Author and is not copied wholly or substantially from any other work or material or any other source; (ii) the Article has not been formally published in any other peer-reviewed journal or in a Journal or edited collection, and is not under consideration for any such publication; (iii) they themselves and any Co-Author are qualifying persons under section 154 of the Copyright, Designs and Patents Act 1988; (iv) they themselves and any Co-Author have not assigned and will not during the term of this Publication Agreement purport to assign any of the rights granted to IntechOpen under this Publication
\\n\\nAgreement; and (v) the rights granted by this Publication Agreement are free from any security interest, option, mortgage, charge or lien.
\\n\\nThe Corresponding Author also warrants and represents that: (i) they have the full power to enter into this Publication Agreement on their own behalf and on behalf of each Co-Author; and (ii) they have the necessary rights and/or title in and to the Article to grant IntechOpen, on behalf of themselves and any Co-Author, the rights and licenses expressed to be granted in this Publication Agreement. If the Article was prepared jointly by the Corresponding Author and any Co-Author, the Corresponding Author warrants and represents that: (i) each Co-Author agrees to the submission, license and publication of the Article on the terms of this Publication Agreement; and (ii) they have the authority to enter into this Publication Agreement on behalf of and bind each Co-Author. The Corresponding Author shall: (i) ensure each Co-Author complies with all relevant provisions of this Publication Agreement, including those relating to confidentiality, performance and standards, as if a party to this Publication Agreement; and (ii) remain primarily liable for all acts and/or omissions of each such Co-Author.
\\n\\nThe Corresponding Author agrees to indemnify and hold IntechOpen harmless against all liabilities, costs, expenses, damages and losses and all reasonable legal costs and expenses suffered or incurred by IntechOpen arising out of or in connection with any breach of the aforementioned representations and warranties. This indemnity shall not cover IntechOpen to the extent that a claim under it results from IntechOpen's negligence or willful misconduct.
\\n\\n4.2 Nothing in this Publication Agreement shall have the effect of excluding or limiting any liability for death or personal injury caused by negligence or any other liability that cannot be excluded or limited by applicable law.
\\n\\n5. TERMINATION
\\n\\n5.1 IntechOpen has a right to terminate this Publication Agreement for quality, program, technical or other reasons with immediate effect, including without limitation (i) if the Corresponding Author or any Co-Author commits a material breach of this Publication Agreement; (ii) if the Corresponding Author or any Co Author (being an individual) is the subject of a bankruptcy petition, application or order; or (iii) if the Corresponding Author or any Co-Author (being a company) commences negotiations with all or any class of its creditors with a view to rescheduling any of its debts, or makes a proposal for or enters into any compromise or arrangement with any of its creditors.
\\n\\nIn case of termination, IntechOpen will notify the Corresponding Author, in writing, of the decision.
\\n\\n6. INTECHOPEN’S DUTIES AND RIGHTS
\\n\\n6.1 Unless prevented from doing so by events outside its reasonable control, IntechOpen, in its discretion, agrees to publish the Article attributing it to the Corresponding Author and any Co-Author.
\\n\\n6.2 IntechOpen has the right to use the Corresponding Author’s and any Co-Author’s names and likeness in connection with scientific dissemination, retrieval, archiving, web hosting and promotion and marketing of the Article and has the right to contact the Corresponding Author and any Co-Author until the Article is publicly available on any platform owned and/or operated by IntechOpen.
\\n\\n6.3 IntechOpen is granted the authority to enforce the rights from this Publication Agreement, on behalf of the Corresponding Author and any Co-Author, against third parties (for example in cases of plagiarism or copyright infringements). In respect of any such infringement or suspected infringement of the copyright in the Article,
\\n\\nIntechOpen shall have absolute discretion in addressing any such infringement which is likely to affect IntechOpen's rights under this Publication Agreement, including issuing and conducting proceedings against the suspected infringer.
\\n\\n7. MISCELLANEOUS
\\n\\n7.1 Further Assurance: The Corresponding Author shall and will ensure that any relevant third party (including any Co-Author) shall, execute and deliver whatever further documents or deeds and perform such acts as IntechOpen reasonably requires from time to time for the purpose of giving IntechOpen the full benefit of the provisions of this Publication Agreement.
\\n\\n7.2 Third Party Rights: A person who is not a party to this Publication Agreement may not enforce any of its provisions under the Contracts (Rights of Third Parties) Act 1999.
\\n\\n7.3 Entire Agreement: This Publication Agreement constitutes the entire agreement between the parties in relation to its subject matter. It replaces and extinguishes all prior agreements, draft agreements, arrangements, collateral warranties, collateral contracts, statements, assurances, representations and undertakings of any nature made by or on behalf of the parties, whether oral or written, in relation to that subject matter. Each party acknowledges that in entering into this Publication Agreement it has not relied upon any oral or written statements, collateral or other warranties, assurances, representations or undertakings which were made by or on behalf of the other party in relation to the subject matter of this Publication Agreement at any time before its signature (together "Pre-Contractual Statements"), other than those which are set out in this Publication Agreement. Each party hereby waives all rights and remedies which might otherwise be available to it in relation to such Pre-Contractual Statements. Nothing in this clause shall exclude or restrict the liability of either party arising out of its pre-contract fraudulent misrepresentation or fraudulent concealment.
\\n\\n7.4 Waiver: No failure or delay by a party to exercise any right or remedy provided under this Publication Agreement or by law shall constitute a waiver of that or any other right or remedy, nor shall it preclude or restrict the further exercise of that or any other right or remedy. No single or partial exercise of such right or remedy shall preclude or restrict the further exercise of that or any other right or remedy.
\\n\\n7.5 Variation: No variation of this Publication Agreement shall be effective unless it is in writing and signed by the parties (or their duly authorized representatives).
\\n\\n7.6 Severance: If any provision or part-provision of this Publication Agreement is or becomes invalid, illegal or unenforceable, it shall be deemed modified to the minimum extent necessary to make it valid, legal and enforceable. If such modification is not possible, the relevant provision or part-provision shall be deemed deleted.
\\n\\nAny modification to or deletion of a provision or part-provision under this clause shall not affect the validity and enforceability of the rest of this Publication Agreement.
\\n\\n7.7 No partnership: Nothing in this Publication Agreement is intended to, or shall be deemed to, establish or create any partnership or joint venture or the relationship of principal and agent or employer and employee between IntechOpen and the Corresponding Author or any Co-Author, nor authorize any party to make or enter into any commitments for or on behalf of any other party.
\\n\\n7.8 Governing law: This Publication Agreement and any dispute or claim (including non-contractual disputes or claims) arising out of or in connection with it or its subject matter or formation shall be governed by and construed in accordance with the law of England and Wales. The parties submit to the exclusive jurisdiction of the English courts to settle any dispute or claim arising out of or in connection with this Publication Agreement (including any non-contractual disputes or claims).
\\n"}]'},components:[{type:"htmlEditorComponent",content:"The Corresponding Author (acting on behalf of all Authors) and INTECHOPEN LIMITED, incorporated and registered in England and Wales with company number 11086078 and a registered office at 5 Princes Gate Court, London, United Kingdom, SW7 2QJ conclude the following Agreement regarding the publication of a Journal Article:
\n\n1. DEFINITIONS
\n\nCorresponding Author: The Author of the Article who serves as a Signatory to this Agreement. The Corresponding Author acts on behalf of any other Co-Author. Co-Author: All other Authors of the Article besides the Corresponding Author. IntechOpen: IntechOpen Ltd., the Publisher of the Journal.
\n\nJournal: The publication as a collection of Articles compiled by IntechOpen .
\n\nArticle: The original literary work created by Corresponding Author and any Co Author that is the subject of this Agreement.
\n\n2. CORRESPONDING AUTHOR'S GRANT OF RIGHTS
\n\n2.1 Subject to the following Article, the Corresponding Author grants and shall ensure that each Co-Author grants, to IntechOpen, during the full term of copyright and any extensions or renewals of that term the following:
\n\n• An irrevocable, worldwide, royalty-free, perpetual, transferable, sublicensable, non-exclusive right to publish, communicate to the public, reproduce, republish, transmit, sell, distribute and otherwise use and make available the Article in whole, partial or adapted from and/or incorporated in or in conjunction with other works, in electronic and print editions of the Publication and in derivative works and on any platform owned and/or operated by IntechOpen, throughout the world, in all languages, and in all media and formats now known or later developed.
\n\n• An irrevocable, worldwide, royalty-free, perpetual, transferable, sublicensable, non-exclusive right to create and store electronic archival copies of the Article, including the right to deposit the Article in open access digital repositories.
\n\n• An irrevocable, worldwide, royalty-free, perpetual, transferable, sublicensable, non-exclusive right to license others to reproduce, translate, republish, transmit and distribute the Article in whole, partial or adapted from and/or incorporated in or in conjunction with other works under the condition that the Corresponding Author and each Co-Author is attributed (currently this is carried out by publishing the Article under a Creative Commons 4.0 International Licence).
\n\nThe aforementioned licenses shall survive the expiry or termination of this Agreement for any reason.
\n\n2.2 The Corresponding Author (on their own behalf and on behalf of any Co-Author) reserves the following rights to the Article but agrees not to exercise them in such a way as to adversely affect IntechOpen's ability to utilize the full benefit of this Publication Agreement: (i) reprographic rights worldwide, other than those which subsist in the typographical arrangement of the Article as published by IntechOpen; and (ii) public lending rights arising under the Public Lending Right Act 1979, as amended from time to time, and any similar rights arising in any part of the world. The Corresponding Author confirms that they (and any Co-Author) are and will remain a member of any applicable licensing and collecting society and any successor to that body responsible for administering royalties for the reprographic reproduction of copyright works.
\n\nSubject to the license granted above, copyright in the Article and all versions of it created during IntechOpen's editing process (including the published version) is retained by the Corresponding Author and any Co-Author.
\n\nSubject to the license granted above, the Corresponding Author and any Co-Author retains patent, trademark and other intellectual property rights to the Article.
\n\n2.3 All rights granted to IntechOpen in this Article are assignable, sublicensable or otherwise transferrable to third parties without the Corresponding Author's or any Co-Author’s specific approval.
\n\n2.4 The Corresponding Author (on their own behalf and on behalf of each Co Author) will not assert any rights under the Copyright, Designs and Patents Act 1988 to object to derogatory treatment of the Article as a consequence of IntechOpen's changes to the Article arising from translation of it, corrections and edits for house style, removal of problematic material and other reasonable edits.
\n\n3. CORRESPONDING AUTHOR'S DUTIES
\n\n3.1 When distributing or re-publishing the Article, the Corresponding Author agrees to credit the Journal in which the Article has been published as the source of first publication, as well as IntechOpen. The Corresponding Author warrants that each Co-Author will also credit the Journal in which the Article has been published as the source of first publication, as well as IntechOpen, when they are distributing or re publishing the Article.
\n\n3.2 When submitting the Article, the Corresponding Author agrees to:
\n\n• Comply with all instructions and guidelines provided by IntechOpen;
\n\n• Produce the Article with all due skill, care and diligence, and in accordance with good scientific practice;
\n\n• Submit all the corrections in due time as defined during the publishing process schedule.
\n\nThe Corresponding Author will be held responsible for the payment of the Article Processing Charge.
\n\nAll payments shall be due 30 days from the date of the issued invoice. The Corresponding Author or the payer on the Corresponding Author's and Co-Authors' behalf will bear all banking and similar charges incurred.
\n\n3.3 The Corresponding Author shall obtain in writing all consents necessary for the reproduction of any material in which a third-party right exists, including quotations, photographs and illustrations, in all editions of the Article worldwide for the full term of the above licenses, and shall provide to IntechOpen upon request the original copies of such consents for inspection (at IntechOpen's option) or photocopies of such consents.
\n\nThe Corresponding Author shall obtain written informed consent for publication from people who might recognize themselves or be identified by others (e.g. from case reports or photographs).
\n\n3.4 The Corresponding Author and any Co-Author shall respect confidentiality rights during and after the termination of this Agreement. The information contained in all correspondence and documents as part of the publishing activity between IntechOpen and the Corresponding Author and any Co-Author are confidential and are intended only for the recipient. The contents may not be disclosed publicly and are not intended for unauthorized use or distribution. Any use, disclosure, copying, or distribution is prohibited and may be unlawful.
\n\n4. CORRESPONDING AUTHOR'S WARRANTY
\n\n4.1 The Corresponding Author represents and warrants that the Article does not and will not breach any applicable law or the rights of any third party and, specifically, that the Article contains no matter that is defamatory or that infringes any literary or proprietary rights, intellectual property rights, or any rights of privacy. The Corresponding Author warrants and represents that: (i) the Article is the original work of themselves and any Co-Author and is not copied wholly or substantially from any other work or material or any other source; (ii) the Article has not been formally published in any other peer-reviewed journal or in a Journal or edited collection, and is not under consideration for any such publication; (iii) they themselves and any Co-Author are qualifying persons under section 154 of the Copyright, Designs and Patents Act 1988; (iv) they themselves and any Co-Author have not assigned and will not during the term of this Publication Agreement purport to assign any of the rights granted to IntechOpen under this Publication
\n\nAgreement; and (v) the rights granted by this Publication Agreement are free from any security interest, option, mortgage, charge or lien.
\n\nThe Corresponding Author also warrants and represents that: (i) they have the full power to enter into this Publication Agreement on their own behalf and on behalf of each Co-Author; and (ii) they have the necessary rights and/or title in and to the Article to grant IntechOpen, on behalf of themselves and any Co-Author, the rights and licenses expressed to be granted in this Publication Agreement. If the Article was prepared jointly by the Corresponding Author and any Co-Author, the Corresponding Author warrants and represents that: (i) each Co-Author agrees to the submission, license and publication of the Article on the terms of this Publication Agreement; and (ii) they have the authority to enter into this Publication Agreement on behalf of and bind each Co-Author. The Corresponding Author shall: (i) ensure each Co-Author complies with all relevant provisions of this Publication Agreement, including those relating to confidentiality, performance and standards, as if a party to this Publication Agreement; and (ii) remain primarily liable for all acts and/or omissions of each such Co-Author.
\n\nThe Corresponding Author agrees to indemnify and hold IntechOpen harmless against all liabilities, costs, expenses, damages and losses and all reasonable legal costs and expenses suffered or incurred by IntechOpen arising out of or in connection with any breach of the aforementioned representations and warranties. This indemnity shall not cover IntechOpen to the extent that a claim under it results from IntechOpen's negligence or willful misconduct.
\n\n4.2 Nothing in this Publication Agreement shall have the effect of excluding or limiting any liability for death or personal injury caused by negligence or any other liability that cannot be excluded or limited by applicable law.
\n\n5. TERMINATION
\n\n5.1 IntechOpen has a right to terminate this Publication Agreement for quality, program, technical or other reasons with immediate effect, including without limitation (i) if the Corresponding Author or any Co-Author commits a material breach of this Publication Agreement; (ii) if the Corresponding Author or any Co Author (being an individual) is the subject of a bankruptcy petition, application or order; or (iii) if the Corresponding Author or any Co-Author (being a company) commences negotiations with all or any class of its creditors with a view to rescheduling any of its debts, or makes a proposal for or enters into any compromise or arrangement with any of its creditors.
\n\nIn case of termination, IntechOpen will notify the Corresponding Author, in writing, of the decision.
\n\n6. INTECHOPEN’S DUTIES AND RIGHTS
\n\n6.1 Unless prevented from doing so by events outside its reasonable control, IntechOpen, in its discretion, agrees to publish the Article attributing it to the Corresponding Author and any Co-Author.
\n\n6.2 IntechOpen has the right to use the Corresponding Author’s and any Co-Author’s names and likeness in connection with scientific dissemination, retrieval, archiving, web hosting and promotion and marketing of the Article and has the right to contact the Corresponding Author and any Co-Author until the Article is publicly available on any platform owned and/or operated by IntechOpen.
\n\n6.3 IntechOpen is granted the authority to enforce the rights from this Publication Agreement, on behalf of the Corresponding Author and any Co-Author, against third parties (for example in cases of plagiarism or copyright infringements). In respect of any such infringement or suspected infringement of the copyright in the Article,
\n\nIntechOpen shall have absolute discretion in addressing any such infringement which is likely to affect IntechOpen's rights under this Publication Agreement, including issuing and conducting proceedings against the suspected infringer.
\n\n7. MISCELLANEOUS
\n\n7.1 Further Assurance: The Corresponding Author shall and will ensure that any relevant third party (including any Co-Author) shall, execute and deliver whatever further documents or deeds and perform such acts as IntechOpen reasonably requires from time to time for the purpose of giving IntechOpen the full benefit of the provisions of this Publication Agreement.
\n\n7.2 Third Party Rights: A person who is not a party to this Publication Agreement may not enforce any of its provisions under the Contracts (Rights of Third Parties) Act 1999.
\n\n7.3 Entire Agreement: This Publication Agreement constitutes the entire agreement between the parties in relation to its subject matter. It replaces and extinguishes all prior agreements, draft agreements, arrangements, collateral warranties, collateral contracts, statements, assurances, representations and undertakings of any nature made by or on behalf of the parties, whether oral or written, in relation to that subject matter. Each party acknowledges that in entering into this Publication Agreement it has not relied upon any oral or written statements, collateral or other warranties, assurances, representations or undertakings which were made by or on behalf of the other party in relation to the subject matter of this Publication Agreement at any time before its signature (together "Pre-Contractual Statements"), other than those which are set out in this Publication Agreement. Each party hereby waives all rights and remedies which might otherwise be available to it in relation to such Pre-Contractual Statements. Nothing in this clause shall exclude or restrict the liability of either party arising out of its pre-contract fraudulent misrepresentation or fraudulent concealment.
\n\n7.4 Waiver: No failure or delay by a party to exercise any right or remedy provided under this Publication Agreement or by law shall constitute a waiver of that or any other right or remedy, nor shall it preclude or restrict the further exercise of that or any other right or remedy. No single or partial exercise of such right or remedy shall preclude or restrict the further exercise of that or any other right or remedy.
\n\n7.5 Variation: No variation of this Publication Agreement shall be effective unless it is in writing and signed by the parties (or their duly authorized representatives).
\n\n7.6 Severance: If any provision or part-provision of this Publication Agreement is or becomes invalid, illegal or unenforceable, it shall be deemed modified to the minimum extent necessary to make it valid, legal and enforceable. If such modification is not possible, the relevant provision or part-provision shall be deemed deleted.
\n\nAny modification to or deletion of a provision or part-provision under this clause shall not affect the validity and enforceability of the rest of this Publication Agreement.
\n\n7.7 No partnership: Nothing in this Publication Agreement is intended to, or shall be deemed to, establish or create any partnership or joint venture or the relationship of principal and agent or employer and employee between IntechOpen and the Corresponding Author or any Co-Author, nor authorize any party to make or enter into any commitments for or on behalf of any other party.
\n\n7.8 Governing law: This Publication Agreement and any dispute or claim (including non-contractual disputes or claims) arising out of or in connection with it or its subject matter or formation shall be governed by and construed in accordance with the law of England and Wales. The parties submit to the exclusive jurisdiction of the English courts to settle any dispute or claim arising out of or in connection with this Publication Agreement (including any non-contractual disputes or claims).
\n"}]},successStories:{items:[]},authorsAndEditors:{filterParams:{},profiles:[{id:"396",title:"Dr.",name:"Vedran",middleName:null,surname:"Kordic",slug:"vedran-kordic",fullName:"Vedran Kordic",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/396/images/7281_n.png",biography:"After obtaining his Master's degree in Mechanical Engineering he continued his education at the Vienna University of Technology where he obtained his PhD degree in 2004. He worked as a researcher at the Automation and Control Institute, Faculty of Electrical Engineering, Vienna University of Technology until 2008. His studies in robotics lead him not only to a PhD degree but also inspired him to co-found and build the International Journal of Advanced Robotic Systems - world's first Open Access journal in the field of robotics.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"441",title:"Ph.D.",name:"Jaekyu",middleName:null,surname:"Park",slug:"jaekyu-park",fullName:"Jaekyu Park",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/441/images/1881_n.jpg",biography:null,institutionString:null,institution:{name:"LG Corporation (South Korea)",country:{name:"Korea, South"}}},{id:"465",title:"Dr",name:"Christian",middleName:null,surname:"Martens",slug:"christian-martens",fullName:"Christian Martens",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"479",title:"Dr.",name:"Valentina",middleName:null,surname:"Colla",slug:"valentina-colla",fullName:"Valentina Colla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/479/images/358_n.jpg",biography:null,institutionString:null,institution:{name:"Sant'Anna School of Advanced Studies",country:{name:"Italy"}}},{id:"494",title:"PhD",name:"Loris",middleName:null,surname:"Nanni",slug:"loris-nanni",fullName:"Loris Nanni",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/494/images/system/494.jpg",biography:"Loris Nanni received his Master Degree cum laude on June-2002 from the University of Bologna, and the April 26th 2006 he received his Ph.D. in Computer Engineering at DEIS, University of Bologna. On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. His research interests include pattern recognition, bioinformatics, and biometric systems (fingerprint classification and recognition, signature verification, face recognition).",institutionString:null,institution:null},{id:"496",title:"Dr.",name:"Carlos",middleName:null,surname:"Leon",slug:"carlos-leon",fullName:"Carlos Leon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Seville",country:{name:"Spain"}}},{id:"512",title:"Dr.",name:"Dayang",middleName:null,surname:"Jawawi",slug:"dayang-jawawi",fullName:"Dayang Jawawi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Technology Malaysia",country:{name:"Malaysia"}}},{id:"528",title:"Dr.",name:"Kresimir",middleName:null,surname:"Delac",slug:"kresimir-delac",fullName:"Kresimir Delac",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/528/images/system/528.jpg",biography:"K. Delac received his B.Sc.E.E. degree in 2003 and is currentlypursuing a Ph.D. degree at the University of Zagreb, Faculty of Electrical Engineering andComputing. His current research interests are digital image analysis, pattern recognition andbiometrics.",institutionString:null,institution:{name:"University of Zagreb",country:{name:"Croatia"}}},{id:"557",title:"Dr.",name:"Andon",middleName:"Venelinov",surname:"Topalov",slug:"andon-topalov",fullName:"Andon Topalov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/557/images/1927_n.jpg",biography:"Dr. Andon V. Topalov received the MSc degree in Control Engineering from the Faculty of Information Systems, Technologies, and Automation at Moscow State University of Civil Engineering (MGGU) in 1979. He then received his PhD degree in Control Engineering from the Department of Automation and Remote Control at Moscow State Mining University (MGSU), Moscow, in 1984. From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. His current research interests are in the fields of intelligent control and robotics.",institutionString:null,institution:{name:"Technical University of Sofia",country:{name:"Bulgaria"}}},{id:"585",title:"Prof.",name:"Munir",middleName:null,surname:"Merdan",slug:"munir-merdan",fullName:"Munir Merdan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/585/images/system/585.jpg",biography:"Munir Merdan received the M.Sc. degree in mechanical engineering from the Technical University of Sarajevo, Bosnia and Herzegovina, in 2001, and the Ph.D. degree in electrical engineering from the Vienna University of Technology, Vienna, Austria, in 2009.Since 2005, he has been at the Automation and Control Institute, Vienna University of Technology, where he is currently a Senior Researcher. His research interests include the application of agent technology for achieving agile control in the manufacturing environment.",institutionString:null,institution:null},{id:"605",title:"Prof",name:"Dil",middleName:null,surname:"Hussain",slug:"dil-hussain",fullName:"Dil Hussain",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/605/images/system/605.jpg",biography:"Dr. Dil Muhammad Akbar Hussain is a professor of Electronics Engineering & Computer Science at the Department of Energy Technology, Aalborg University Denmark. Professor Akbar has a Master degree in Digital Electronics from Govt. College University, Lahore Pakistan and a P-hD degree in Control Engineering from the School of Engineering and Applied Sciences, University of Sussex United Kingdom. Aalborg University has Two Satellite Campuses, one in Copenhagen (Aalborg University Copenhagen) and the other in Esbjerg (Aalborg University Esbjerg).\n· He is a member of prestigious IEEE (Institute of Electrical and Electronics Engineers), and IAENG (International Association of Engineers) organizations. \n· He is the chief Editor of the Journal of Software Engineering.\n· He is the member of the Editorial Board of International Journal of Computer Science and Software Technology (IJCSST) and International Journal of Computer Engineering and Information Technology. \n· He is also the Editor of Communication in Computer and Information Science CCIS-20 by Springer.\n· Reviewer For Many Conferences\nHe is the lead person in making collaboration agreements between Aalborg University and many universities of Pakistan, for which the MOU’s (Memorandum of Understanding) have been signed.\nProfessor Akbar is working in Academia since 1990, he started his career as a Lab demonstrator/TA at the University of Sussex. After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. He has contributed in stochastic estimation of control area especially, in the Multiple Target Tracking and Interactive Multiple Model (IMM) research, Ball & Beam Control Problem, Robotics, Levitation Control. He has contributed in developing Algorithms for Fingerprint Matching, Computer Vision and Face Recognition. He has been supervising Pattern Recognition, Formal Languages and Distributed Processing projects for several years. He has reviewed many books on Management, Computer Science. Currently, he is an active and permanent reviewer for many international conferences and symposia and the program committee member for many international conferences.\nIn teaching he has taught the core computer science subjects like, Digital Design, Real Time Embedded System Programming, Operating Systems, Software Engineering, Data Structures, Databases, Compiler Construction. 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