Characteristics of the stretches of Itaipu.
\\n\\n
IntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\\n\\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
\\n\\nLaunching 2021
\\n\\nArtificial Intelligence, ISSN 2633-1403
\\n\\nVeterinary Medicine and Science, ISSN 2632-0517
\\n\\nBiochemistry, ISSN 2632-0983
\\n\\nBiomedical Engineering, ISSN 2631-5343
\\n\\nInfectious Diseases, ISSN 2631-6188
\\n\\nPhysiology (Coming Soon)
\\n\\nDentistry (Coming Soon)
\\n\\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\\n\\nNote: Edited in October 2021
\\n"}]',published:!0,mainMedia:{caption:"",originalUrl:"/media/original/132"}},components:[{type:"htmlEditorComponent",content:'With the desire to make book publishing more relevant for the digital age and offer innovative Open Access publishing options, we are thrilled to announce the launch of our new publishing format: IntechOpen Book Series.
\n\nDesigned to cover fast-moving research fields in rapidly expanding areas, our Book Series feature a Topic structure allowing us to present the most relevant sub-disciplines. Book Series are headed by Series Editors, and a team of Topic Editors supported by international Editorial Board members. Topics are always open for submissions, with an Annual Volume published each calendar year.
\n\nAfter a robust peer-review process, accepted works are published quickly, thanks to Online First, ensuring research is made available to the scientific community without delay.
\n\nOur innovative Book Series format brings you:
\n\nIntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\n\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
\n\nLaunching 2021
\n\nArtificial Intelligence, ISSN 2633-1403
\n\nVeterinary Medicine and Science, ISSN 2632-0517
\n\nBiochemistry, ISSN 2632-0983
\n\nBiomedical Engineering, ISSN 2631-5343
\n\nInfectious Diseases, ISSN 2631-6188
\n\nPhysiology (Coming Soon)
\n\nDentistry (Coming Soon)
\n\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\n\nNote: Edited in October 2021
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"7094",leadTitle:null,fullTitle:"Advances in the Diagnosis and Management of Uveitis",title:"Advances in the Diagnosis and Management of Uveitis",subtitle:null,reviewType:"peer-reviewed",abstract:"Uveitis is the fifth cause of visual loss in the developed world, accounting for up to 20% of legal blindness. Visual loss due to uveitis currently has a significant impact on the productivity and quality of life of many patients worldwide. Therefore, advances in diagnostic techniques and therapeutic strategies are crucial for patients suffering from the disease. Improvements in our understanding of the pathogenic mechanisms, development of more accurate diagnostic tests, and better treatment alternatives come from the continuous efforts of researchers from all over the world who are committed to improving the standard of care of patients suffering from these potentially blinding diseases.This book focuses on the most recent advances in diagnostic techniques for primary and systemic-associated autoimmune and infectious uveitis, as well as new therapeutic strategies that have significantly reduced the rate of ocular complications and improved the visual outcome of patients suffering from these devastating disorders.",isbn:"978-1-83880-543-2",printIsbn:"978-1-83880-542-5",pdfIsbn:"978-1-83880-712-2",doi:"10.5772/intechopen.73886",price:119,priceEur:129,priceUsd:155,slug:"advances-in-the-diagnosis-and-management-of-uveitis",numberOfPages:146,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"a81511ced9080932669447918c9b5f72",bookSignature:"Alejandro Rodriguez-Garcia and C. Stephen Foster",publishedDate:"May 29th 2019",coverURL:"https://cdn.intechopen.com/books/images_new/7094.jpg",numberOfDownloads:8163,numberOfWosCitations:4,numberOfCrossrefCitations:8,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:12,numberOfDimensionsCitationsByBook:2,hasAltmetrics:1,numberOfTotalCitations:24,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"June 12th 2018",dateEndSecondStepPublish:"August 31st 2018",dateEndThirdStepPublish:"October 30th 2018",dateEndFourthStepPublish:"January 18th 2019",dateEndFifthStepPublish:"March 19th 2019",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"209514",title:"Dr.",name:"Alejandro",middleName:null,surname:"Rodriguez-Garcia",slug:"alejandro-rodriguez-garcia",fullName:"Alejandro Rodriguez-Garcia",profilePictureURL:"https://mts.intechopen.com/storage/users/209514/images/system/209514.jpg",biography:"Dr. Alejandro Rodriguez-Garcia completed a Clinical and Research Fellowship in Ocular Immunology and Uveitis at the Massachusetts Eye and Ear Infirmary, Harvard Medical School. He is a Distinguished Clinical and Research Professor of Ophthalmology at Tecnologico de Monterrey School of Medicine and Health Sciences, Mexico. He is Director of the Ocular Immunology and Uveitis Service at the Institute of Ophthalmology and Visual Sciences, Academic Director of the Ophthalmology Residency Program, and member of CONACYT National System of Researchers (Level 2). He is a former President of the Center for Ocular Inflammatory Disorders affiliated with the Mexican Society of Ophthalmology. Dr. Rodriguez is the author and co-author of more than 100 peer-reviewed scientific articles and more than thirty chapters related to inflammatory and infectious eye diseases.",institutionString:"Monterrey Institute of Technology and Higher Education",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"3",totalChapterViews:"0",totalEditedBooks:"2",institution:{name:"Monterrey Institute of Technology and Higher Education",institutionURL:null,country:{name:"Mexico"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:{id:"257222",title:"Dr.",name:"C. Stephen",middleName:null,surname:"Foster",slug:"c.-stephen-foster",fullName:"C. Stephen Foster",profilePictureURL:"https://mts.intechopen.com/storage/users/257222/images/system/257222.jpeg",biography:"C. Stephen Foster, MD, FAC., FACR, is the Founder and President of the Massachusetts Eye Research and Surgery Institute and the Ocular Immunology and Uveitis Foundation. He is also a Professor of Ophthalmology, part-time, and an Adjunct Professor of Allergy and Immunology, Harvard Medical School; a surgeon in Ophthalmology at the Massachusetts Eye and Ear Infirmary; and a Clinical Associate in Surgery, Massachusetts General Hospital, Harvard Medical School. Dr. Foster received the American Academy of Ophthalmology Award in 1983, the Research to Prevent Blindness Senior Scientific Investigator Award in 1995, and the Mildred Weisenfeld Award for Excellence in Ophthalmology in 2005. He also received a lifetime achievement award from the Academy of Ophthalmology in 2007. In 2016, he was named as one of America’s top doctors in ophthalmology for the 15th consecutive year.",institutionString:"Harvard Medical School",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"Harvard University",institutionURL:null,country:{name:"United States of America"}}},coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"1094",title:"Ophthalmic Pathology",slug:"ophthalmic-pathology"}],chapters:[{id:"66914",title:"Introductory Chapter: Current and Future Trends in the Diagnosis and Management of Uveitis",doi:"10.5772/intechopen.86377",slug:"introductory-chapter-current-and-future-trends-in-the-diagnosis-and-management-of-uveitis",totalDownloads:1049,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Alejandro Rodriguez-Garcia and C. Stephen Foster",downloadPdfUrl:"/chapter/pdf-download/66914",previewPdfUrl:"/chapter/pdf-preview/66914",authors:[{id:"209514",title:"Dr.",name:"Alejandro",surname:"Rodriguez-Garcia",slug:"alejandro-rodriguez-garcia",fullName:"Alejandro Rodriguez-Garcia"},{id:"408090",title:"Dr.",name:"C.",surname:"Stephen Foster",slug:"c.-stephen-foster",fullName:"C. Stephen Foster"}],corrections:null},{id:"66958",title:"Vogt-Koyanagi-Harada Disease",doi:"10.5772/intechopen.85261",slug:"vogt-koyanagi-harada-disease",totalDownloads:921,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Vogt-Koyanagi-Harada (VKH) disease is an autoimmune disorder characterized by bilateral intraocular inflammation, exudative retinal detachments, and extraocular manifestations in the auditory, integumentary, and central nervous systems (CNS). This condition is driven by T-cell-mediated autoimmunity directed against melanocytes present in the uveal tissue, in a specific genetic context. The diagnosis is based on clinical presentation, accounting with a set of standardized diagnostic criteria. Studies have reported that patients who have a significant delay in the diagnosis and/or clinical signs of the chronic stage of the disorder have a poorer prognosis and thus special efforts have to be performed in order to have an early diagnosis, together with an appropriate treatment. In that sense, the development of tools that allow us to detect this disease and its degree of severity is extremely important. In this line, novel candidate biomarkers—such as quantification of mRNA levels of NOD and glucocorticoid receptor—have been recently reported, and they represent significant advances that can help the clinician to improve patient categorization and outcomes.",signatures:"Cristhian A. Urzua",downloadPdfUrl:"/chapter/pdf-download/66958",previewPdfUrl:"/chapter/pdf-preview/66958",authors:[{id:"270744",title:"M.D.",name:"Cristhian",surname:"Urzua",slug:"cristhian-urzua",fullName:"Cristhian Urzua"}],corrections:null},{id:"66274",title:"Behcet’s Disease",doi:"10.5772/intechopen.85265",slug:"behcet-s-disease",totalDownloads:927,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Defined as a systemic vasculitis developing in a particular genetic background, uveitis is one of the hallmarks to diagnose Behcet’s disease and also one of the important clinical criteria to start systemic treatment. Isolated anterior non granulomatous uveitis with hypopyon, even though a classic clinical picture, actually develops in a minority of cases. In most patients, uveitis is posterior, associated to small vessel occlusive retinal vasculitis, carrying a high risk of permanent retinal damage and subsequent severe visual loss. The guarded natural prognosis of the disease has positively changed in the last decennials with the introduction of biologic immunosuppressant agents in the field of uveitis. Vision can be preserved in most cases provided a prompt early diagnosis and adequate therapy. The potential role of oral bacteria as a triggering factor for autoinflammation in predisposed hosts is interesting, opening the door to prevention in this still not well-understood severe uveitis.",signatures:"Karina Julian and Bahram Bodaghi",downloadPdfUrl:"/chapter/pdf-download/66274",previewPdfUrl:"/chapter/pdf-preview/66274",authors:[{id:"272315",title:"Prof.",name:"Bahram",surname:"Bodaghi",slug:"bahram-bodaghi",fullName:"Bahram Bodaghi"},{id:"272318",title:"Dr.",name:"Karina",surname:"Julian",slug:"karina-julian",fullName:"Karina Julian"}],corrections:null},{id:"64436",title:"Viral Retinitis: Diagnosis and Management Update",doi:"10.5772/intechopen.82070",slug:"viral-retinitis-diagnosis-and-management-update",totalDownloads:961,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Cytomegalovirus, herpes simplex, and herpes zoster are responsible for the majority of cases of viral retinitis and can occur in both healthy and immunocompromised or immunodeficient individuals. Herpes zoster has been strongly incriminated as a causal agent in acute retinal necrosis in immunocompetent patients. Epstein Barr virus has been described in various ocular inflammatory diseases including multifocal choroiditis in healthy patients. In immunocompromised or immunodeficient patients, various opportunistic viral infections can occur; the most common being cytomegalovirus (CMV) infection. Other less common viruses causing retinal infections include herpes simplex virus (HSV) and varicella zoster virus (VZV). The vision-threatening complications associated with infectious viral disease are disastrous in nature due to rapid progression. The inability to control this viral retinitis requires early detection by the clinician with prompt and aggressive initiation of the drug therapy to prevent complications.",signatures:"Abhinav Dhami and Ravinder Kaur Malhi",downloadPdfUrl:"/chapter/pdf-download/64436",previewPdfUrl:"/chapter/pdf-preview/64436",authors:[{id:"263809",title:"Dr.",name:"Abhinav",surname:"Dhami",slug:"abhinav-dhami",fullName:"Abhinav Dhami"},{id:"267111",title:"Dr.",name:"Ravinder",surname:"Malhi",slug:"ravinder-malhi",fullName:"Ravinder Malhi"}],corrections:null},{id:"64998",title:"Tuberculosis and Immunosuppressive Treatment in Uveitis Patients",doi:"10.5772/intechopen.82773",slug:"tuberculosis-and-immunosuppressive-treatment-in-uveitis-patients",totalDownloads:955,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:0,abstract:"Uveitis is reported to be related to tuberculosis in 0.2–20% of cases. This large range reflects prevalence variations of tuberculosis around the globe as well as differences in diagnostic criteria. In addition, patients with noninfectious uveitis are frequently treated by immunomodulatory drugs and are thus at risk of TB reactivation. Search for tuberculosis infection is thus an important aspect in the work-up of patients with uveitis, even in low prevalence area. In the work up of such patients, the first question to ask is whether the patient has been infected by mycobacterium tuberculosis or not. The second question is to determine whether the uveitis is due or linked to this mycobacterial infection or not. Classical tuberculosis screening tools are used to answer the first question (TST, IGRA and chest X ray). The answer to the second question is much more challenging and will require the exclusion of other causes, to consider epidemiological data and clinical signs, polymerase chain reaction (PCR) on ocular fluids and therapeutically treatment trial. Disease prevalence will greatly influence all proposed tests and the final diagnosis. Tuberculosis prevalence in Western countries has progressively decreased during the twentieth century but remains elevated in cities with large migrating populations and drug addicts, with an increase of ultra-resistant cases. All those data must be carefully analyzed in order to collect enough evidences supporting tuberculosis uveitis before the initiation of a treatment with potential serious side and adapt the treatment to the increasing resistance.",signatures:"François Willermain, Laure Caspers, Weber Celia and Dorine Makhoul",downloadPdfUrl:"/chapter/pdf-download/64998",previewPdfUrl:"/chapter/pdf-preview/64998",authors:[{id:"271611",title:"Prof.",name:"Laure",surname:"Caspers",slug:"laure-caspers",fullName:"Laure Caspers"},{id:"272196",title:"Prof.",name:"François",surname:"Willermain",slug:"francois-willermain",fullName:"François Willermain"},{id:"272197",title:"Dr.",name:"Dorine",surname:"Makhoul",slug:"dorine-makhoul",fullName:"Dorine Makhoul"},{id:"272312",title:"Dr.",name:"Celia",surname:"Weber",slug:"celia-weber",fullName:"Celia Weber"}],corrections:null},{id:"64694",title:"A Novel Ocular Drug Delivery System of Dexamethasone Sodium Phosphate for Noninfectious Uveitis Treatment",doi:"10.5772/intechopen.82388",slug:"a-novel-ocular-drug-delivery-system-of-dexamethasone-sodium-phosphate-for-noninfectious-uveitis-trea",totalDownloads:1129,totalCrossrefCites:2,totalDimensionsCites:3,hasAltmetrics:0,abstract:"Treatment of anterior uveitis commonly requires 6–8 times daily administration of eye drops, which often leads to poor patient compliance. The treatment of intermediate and posterior uveitis is restricted to either oral medications with significant systemic side effects or local invasive methods, which are more expensive and associated with the development of ocular complications. There is an unmet need for a new drug delivery system that addresses these challenges. DSP-Visulex is a noninvasive drug delivery system that administers dexamethasone sodium phosphate by passive diffusion through the limbal sclera into the interior of the eye utilizing the transscleral pathway. Once-a-week administration of DSP-Visulex treatment regimens (i.e., 1–5 doses per month) has shown to be safe and efficacious for noninfectious uveitis in animal models including anterior uveitis, posterior uveitis, and/or panuveitis. In a clinical study of anterior uveitis, the DSP-Visulex treatments also have been shown to be safe and well tolerated and their efficacy (administered on days 1, 3, 8, and 15 with an optional treatment on Day 22) was comparable to that of the daily prednisolone acetate drops.",signatures:"Kongnara Papangkorn, John W. Higuchi, Balbir Brar and William I. Higuchi",downloadPdfUrl:"/chapter/pdf-download/64694",previewPdfUrl:"/chapter/pdf-preview/64694",authors:[{id:"265192",title:"Dr.",name:"Kongnara",surname:"Papangkorn",slug:"kongnara-papangkorn",fullName:"Kongnara Papangkorn"},{id:"277392",title:"Mr.",name:"John",surname:"Higuchi",slug:"john-higuchi",fullName:"John Higuchi"},{id:"277393",title:"Prof.",name:"William",surname:"Higuchi",slug:"william-higuchi",fullName:"William Higuchi"},{id:"277394",title:"Dr.",name:"Balbir",surname:"Brar",slug:"balbir-brar",fullName:"Balbir Brar"}],corrections:null},{id:"64592",title:"Biological Therapies that Target Inflammatory Cytokines to Treat Uveitis",doi:"10.5772/intechopen.82252",slug:"biological-therapies-that-target-inflammatory-cytokines-to-treat-uveitis",totalDownloads:1038,totalCrossrefCites:3,totalDimensionsCites:4,hasAltmetrics:0,abstract:"Uveitis is a leading cause of blindness that presents a considerable challenge given that our understanding of the mechanisms of disease is still evolving. Both innate and adaptive immunity play a role in disease and mediators of these responses can serve as therapeutic targets. TNF-α and IL-1β inflammatory cytokines are central mediators of immunity and are involved in the dysregulated inflammatory response during uveitis. Because toxicity limits the use of steroids and other steroid-sparing agents, biologics that target a specific cell type or pathway are being explored for the treatment of autoimmune uveitis. This chapter begins with a broad overview of the aberrant immune response resulting in uveitis, and highlights key mediators such as TNF-α, IL-1β, IL-6, and IL-17 and their potential use as therapeutic targets. Most biological agents discussed in this review have not been FDA-approved for uveitis. However, favorable outcomes in early trials and FDA approval of these drugs for the treatment of other autoimmune diseases associated with uveitis support the potential for these biological agents in the management of uveitis. This review aims to provide an updated report on the efficacy of biologics that target TNF-α, IL-1β, IL-6, and IL-17 for the treatment of autoimmune uveitis.",signatures:"Ashvini Reddy, Fauziyya Muhammad and Darren J. Lee",downloadPdfUrl:"/chapter/pdf-download/64592",previewPdfUrl:"/chapter/pdf-preview/64592",authors:[{id:"264148",title:"Prof.",name:"Darren",surname:"Lee",slug:"darren-lee",fullName:"Darren Lee"},{id:"278741",title:"Prof.",name:"Ashvini",surname:"Reddy",slug:"ashvini-reddy",fullName:"Ashvini Reddy"},{id:"278742",title:"Dr.",name:"Fauziyya",surname:"Muhammad",slug:"fauziyya-muhammad",fullName:"Fauziyya Muhammad"}],corrections:null},{id:"65004",title:"Tumor Necrosis Factor-Alpha Inhibitory Therapy for Non-Infectious Autoimmune Uveitis",doi:"10.5772/intechopen.82800",slug:"tumor-necrosis-factor-alpha-inhibitory-therapy-for-non-infectious-autoimmune-uveitis",totalDownloads:1184,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:1,abstract:"Biologic agents represent a mainstay in the treatment of refractory non-infectious, immune-mediated uveitis. Tumor necrosis factor (TNF)-α inhibitors have demonstrated efficacy in inducing and sustaining disease remission in numerous systemic inflammatory disorders and their associated uveitic entities. In particular, studies have shown that infliximab and adalimumab can induce steroid-free disease remission in patients with Behçet’s disease and juvenile arthritis as treatments that are superior to conventional disease-modifying immunosuppressive agents. Patients receiving anti-TNF-α therapy may experience adverse events and should be closely monitored for the development of opportunistic infections, reactivation of tuberculosis and hepatitis, demyelinating disease and neuropathies, as well as malignancies.",signatures:"Judy L. Chen, Ann-Marie Lobo-Chan, Robison Vernon Paul Chan and Pooja Bhat",downloadPdfUrl:"/chapter/pdf-download/65004",previewPdfUrl:"/chapter/pdf-preview/65004",authors:[{id:"272319",title:"Prof.",name:"Robison",surname:"Chan",slug:"robison-chan",fullName:"Robison Chan"},{id:"273397",title:"Dr.",name:"Pooja",surname:"Bhat",slug:"pooja-bhat",fullName:"Pooja Bhat"},{id:"273398",title:"Dr.",name:"Ann-Marie",surname:"Lobo",slug:"ann-marie-lobo",fullName:"Ann-Marie Lobo"},{id:"282822",title:"Dr.",name:"Judy",surname:"Chen",slug:"judy-chen",fullName:"Judy Chen"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"10345",title:"Infectious Eye Diseases",subtitle:"Recent Advances in Diagnosis and Treatment",isOpenForSubmission:!1,hash:"1d2abb832f0773c90fc9a12d1a41194c",slug:"infectious-eye-diseases-recent-advances-in-diagnosis-and-treatment",bookSignature:"Alejandro Rodriguez-Garcia and Julio C. 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\r\n\tIt has been established that energy/nutrient depletion, calcium flux injury, or oxidative stress disrupt endoplasmic reticulum homeostasis and even induce accumulation of misfolded/unfolded proteins leading to endoplasmic reticulum stress. Under endoplasmic reticulum stress conditions, an adaptive mechanism of coordinated signaling pathways, defined unfolded protein response (UPR), is activated to return the endoplasmic reticulum to its healthy functioning state. The aging causes a decrease of the protective adaptive response of the UPR and an increase of the pro-apoptotic pathway together with endoplasmic reticulum ultrastructural injury. Controlling endoplasmic reticulum stress response, maintaining the appropriate endoplasmic reticulum ultrastructure and homeostasis, and retaining mitochondria interplay are crucial aspects for cellular health.
\r\n\tThis book presents a comprehensive overview of endoplasmic reticulum, including, but not limited to, endoplasmic reticulum ultrastructural anatomy, MAMs, endoplasmic reticulum stress, and their implication in health and diseases. Additionally, identifying perturbations in the endoplasmic reticulum stress response could lead to early detection of age-related disease and may help develop therapeutic approaches.
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She is currently engaged as a researcher for the Scientific-Disciplinary Sector BIO/16 Human Anatomy at the Anatomy and Pathophysiology Division, Department of Clinical and Experimental Sciences, University of Brescia (Italy).\r\nDr. Favero focuses on aging-related morphological dysfunctions as the prelude to various pathophysiological processes in her research programs. The central hypothesis is that natural antioxidants and, in particular, melatonin may act as molecular "switches" that modulate cells and tissues by suppressing, at various levels, oxidative stress and inflammatory signalling cascades. These research approaches represent powerful tools for developing innovative preventive strategies and identifying novel prognostic biomarkers for several diseases. 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It is important to select the information that better “explain” the behavior of the dam, making possible the prediction and resolution of eventual problems that may occur.
The world largest hydroelectricity generator, Itaipu hydroelectric power plant, has more than 2.200 instruments that monitor its geotechnical and structural behavior, and these instruments have readings stored on a database for over 30 years. The high dimensionality and the large quantity of records stored on the databases are nontrivial problems that are kept so that one can pursue "knowledge" through these data.
The detailed analysis of the auscultation instrumental data requires a combination of knowledge of Engineering, Mathematics and Statistics, as well as the previous experience of the engineer or the technician responsible for the analysis of these data. That consumes a lot of time, and often makes it impossible to accomplish this task in an efficient way. This is the reason why the use of techniques and computational instrumentation to help the decisions maker is extremely important.
There are no records of the existence of methods that perform the classification of monitoring instruments in dams. In case of reading intensification this hierarchy could be useful to define which instrument to chose.
The aim of this paper is to identify the tools that are the most significant for the analysis of a dam behavior, which maximizes the effectiveness and efficiency of the analysis of the readings. It shows a methodology based on the field of Multivariate Analysis, applied to the Hierarchical Cluster Analysis in order to identify the groups of instruments similar to Ward’s linkage method. The factor analysis of the strain gauge of each instrument group was also applied, performing the hierarchical cluster of monitoring instruments in dams, detecting the main instruments.
This chapter is organized as follows: Section 2 features the problem statement which addresses the importance of the safety on dams and the risks faced when dam rupture accident occurs. Section 3 describes the application area focusing on the safety of dams, on the conditions of load and on the conditions of the monitoring instrument. Section 4 approaches a “research course”. Section 5 describes the used data and the Multivariate Statistical Analysis techniques. Section 6 shows the status. Section 7 shows the results. Section 8 approaches the future researches. Section 9 shows the results.
Once the potential risks and losses as a result of rupture accidents on a dam can reach large scales a safe project and adequate construction as well as a correct operation on dams are concerns of Brazilian and worldwide engineers. Additionally, an effectively done monitoring on large dams is essential for the safety of its structure. By aiming the safety of the dams, International Guidelines and many helpful discussions about this subject have been proposed and conducted, such as the one from the [1].
In Brazil, guidelines that aim the safety of the dams were published by the
The concerns about the Brazilian Constitutional Public Powers is due to the recent rupture of the Dam of Câmara, (in the State of Pará - PA), in 2004; the rupture of the diversion structure of the Dam of Campos Novos, (in the State of Santa Catarina - SC), in 2006; the rupture of the Dam of Algodões I, (in the State of Piauí - PI), in 2009; and other accidents of smaller magnitude.
According to [4], the catastrophes have been opportune signs for the examination of the criteria of the existing projects and for the selection of more efficient methods and monitoring safety of dams.
In [5] show a table which contains the estimative for the most common causes of ruptures on dams. Among them, the following are highlighted: problems of the foundation; inappropriate spillway; structural problem; different declinations; extreme low-pressure; rupture of landfills; defective materials; incorrect operation; actions of war, and earthquakes. All these problems can be diagnosed with the monitoring of the dam instrumentation, with exception of the last two ones, which percentage of frequencies sum just 4%.
According to [6], the global experience shows that the expenses in order to guarantee the safety of a dam are little when compared to the costs of its rupture. The author quotes the importance of the use of a database of instrumentation for supporting the preliminary analysis of the readings in order to detect problems.
The principles established on NBR 8681 –
The stability of dams must be primary analyzed during the phase of the project. The geometry of the structures and the property of the materials involved must be well considered, as well as the load condition. Some of the basic load conditions are shown on Figure 1.
Illustration of the basic conditions of load and lack of stability of gravity concrete dams.
Through Physics, it is possible to explain that the difference of the water level (downstream-upstream) generates a hydraulic gradient between the dam downstream and upstream making the water of the reservoir to try passing through upstream in order to archive a hydraulic equilibrium. To do so, the water percolates through the foundation mass of the dam. During this process, the infiltrated water generates vertical forces acting upward over the dam, these forces are called uplift pressure in dam. The resultant of these forces is represented by Fuplift. Furthermore, the water from the reservoir generates horizontal forces that act downstream-upstream over the dam. These forces are called hydrostatic pressures against the dam wall. The resultants of these forces are represented by Freservoir. These two resultant forces are called destabilizing forces. As for the force P (dam weight) it is a stabilizing structure force. The combination of Fuplift and Freservoir can cause the overturning and the slipping of the dam, not just because of the efforts and moment when it is directly applied, but also for the relief of the weight of the structure itself (in case of uplift pressure).
The above described effects of loads on dams can be observed on figure 1, where the slipping (a) and the overturning (b) are emphasized.
The loading conditions and the properties of materials can change over the lifecycle of a dam, and instrumentation can identify some of these changes.
Figure 2 shows the differences in the behavior of the dam in relation to summer and winter climate conditions, as well as its consequences. In summer, an expansion of the concrete occurs, and that causes the block to tumble downstream. This overturning causes the block to compress the foundation. In winter, the concrete is compressed causing the block to tumble upstream, returning to initial position. As a consequence the pressure that occurs in summer over the foundation to be relieved. In this way, it is possible to identify a cyclical behavior of the structure, intrinsically conditioned by the environmental conditions which involve the construction.
Behavior of the dam in relation to summer and winter climate conditions (Adapted from [
According to [9], the instrumentation must be used as supplement to visual inspection when executing the evaluation of the performance and safety of dams. The careful inspection of the instrumentation data can reveal a critical condition.
In [10] shows correlations between the types of instruments that are usually used for the auscultation on concrete dams, and the primary types of deterioration of concrete dams. According to the author, the multiple extensometer for example, is related to the monitoring of deteriorations caused by sliding, different declinations, land subsidence of the upstream base, and the Alkali-Aggregate Reactivity.
The measurement of the declinations is one of the most important observations for monitoring a dam behavior during the period of construction, of dams filling and operation. The measurement of the declination can be performed through a multiple point rod extensometer installed on boreholes [10]. Figure 3 shows the multiple point rod extensometer and an example of a typical profile of a multiple point rod extensometer at
Multiple point rod extensometer and a example of a typical profile of a multiple point rod extensometer at
The measurements of displacements and deformation can be performed in several parts of the foundation with the usage of various rods. Among these displacement and deformations are the contact of concrete and rock, joints and faults and other sub-horizontal discontinuities in the foundation. This approach was used at the Itaipu Dam, where different points of foundation mass were instrumented, specially the geological discontinuities. Figure 4 shows a typical geological profile of the foundation mass of the Itaipu Dam part, which has no tunnel in its right-side, where primary geological discontinuities can be found (contacts, joints, and gaps) of that specific site. In blocks where there is a transversal gallery access to the shaft, the installation of downstream-upstream extensometers can help in the measurement of the angular displacement of the dam with the foundation [10].
Schematic geological profile of the foundation of Itaipu (ITAIPU BINACIONAL, 1995,
The measurement of the horizontal displacement of the ridge is a relevant parameter which is affected by deflections of the concrete structure, by the rotation of the base of the structure (due to the deformability of the foundation), and by thermal and environmental influences. These displacements are affected by the characteristics of the concrete or by the proprieties of the foundation rock mass, resulting in important information for the auscultation of the behavior of the dam and of its foundation. The horizontal displacements of the ridge can be measured by a direct pendulum, usually installed at the end of the construction process. The measurements are done on the stages of reservoir spillway and of dam operation [10].
The stability of the structure in terms of sliding, overturning or floating is directly affected by the level of the piezometric pressures in the concrete-rock interface and in the sub horizontal discontinuities of low resistance that exists in the foundation. The measurements of low pressures on the concrete dam foundation are important for the monitoring of its safety conditions. The drainage is one of the most efficient ways to ensure adequate safety coefficients. The measurements of low pressure are performed by the piezometer [10].
The Itaipu Binacional, the largest energy producer of the world, had its construction started in 1973 at a river stretch of Rio Paraná known as Itaipu, which in Tupi language means “the singing boulder”, located in the heart of Latin America, on the border of Brazil and Paraguay [12]. The construction of the dam ended in 1982 and the last generator unit was completed in 2008.
Nowadays, the Itaipu Dam has 20 generator units of 700 MW (megawatts) each, generating a total potential of 14.000 MW. Itaipu Binacional (Bi-national Itaipu) reached its record in producing energy in 2000, generating over 93,4 billions kilowatts-hour (KWh). It is responsible for supplying 95% of the energy consumed in Paraguay and 24% of all the Brazilian consumption.
The Itaipu Dam has 7.919m of extension and a maximum high of 196m; these dimensions made of the Itaipu construction a reference in concrete, and dam safety studies. Itaipu dam is made of two stretches of earth dam, one stretch of rock-fill dams and concrete stretches, and these forms the higher structures of it. Figure 5 illustrates the whole structure of the Itaipu dam, and table 1 shows the main characteristics of the stretches pointed on figure 5.
Whole structure of the Itaipu Complex [
It is possible to find in all the Itaipu extension an amount of 2.218 instruments (1.362 in the concrete, and 865 in the foundations and earthen embankments) and from this amount 270 of them are automated, to monitor the performance of the concrete structures and foundations. Furthermore, there are 5.239 drains (949 in the concrete and 4.290 in the foundations). The readings of these instruments occur in different frequencies, they can be, for example, daily, weekly, fortnightly, and monthly, depending on the type of instrument. These readings have been stored for over 30 years.
Even though, every stretch of the dam is instrumented and monitored, one of the stretches, called
Stretch | Structure | Lenth (m) | Maximun high (m) | |
1 | Auxiliary Dam(Saddle Dam) | Earth | 2294 | 30 |
2 | Auxiliary Dam(Saddle Dam) | Rock-filling | 1984 | 70 |
3 and 7 | Lateral Dams | Couterfort | 1438 | 81 |
4 | Deviation Structure | Concrete mass | 170 | 162 |
5 | Main Dam (TStretch F) | Reliefed Gravity | 612 | 196 |
9 | Auxiliary Dam | Terra | 872 | 25 |
Other strwtches | Características | |||
6 | Powerhouse | 20 Generator units | ||
8 | Spillway | 350 m length |
Characteristics of the stretches of Itaipu.
In the stretch F it is possible to find extensometers, piezometers, triothogonal meter, water level gauge and foundation instrumentation (seepage flow meter). Among these instruments, the multiple point rod extensometers, that are installed in boreholes, were selected for the analysis. This type of instrument is considered one of the most important because they are responsible for measuring the vertical displacement. That is one of the most important observations while monitoring the behavior of the dam structure. There are 30 extensometers located in stretch F.
The procedure for the methodology used for the analysis of the problem of
In the first phase, the data were selected and it was decided that the methodology would be applied only to the extensometers located in stretch F.
In the second phase, the data given by
In the third phase, the data were standardized in order to receive the subsequent application of the clustering methods.
In the fourth phase, the Factor Analysis and the Clustering Analysis were applied at the same time. The Factor Analysis was also applied within each cluster formed through Clustering Analysis.
The methodology used for the analysis was applied to the data of 30 extensometers located in different blocks of stretch F of the dam, which having one or two point rods, totalizes 72 displacement measures. These measurements are identified as follow: equip4_1, meaning rod 1 of the extensometer 4, and so on.
The data used in this study are monthly stored and they correspond to the period of January/1995 to December/2004, totalizing 120 readings. This period was chosen as a suggestion of the engineer team of Itaipu because it is subsequent the construction of the dam and prior to the system of automatic acquisition of data. During the period of system implementation, some instruments ended up having no manual readings, in addition, a total of 11 automated instruments (totalizing 24 rods) went through modifications that might have influenced the subsequent readings; there was an exchange on the instrument head for a 70 cm longer one. In this way, the referred 120 readings were immune to these irregularities.
During the period of pre-processing the data, it was identified that most of the instruments readings are monthly, but some of them showed more than one reading per month, so for this cases, the monthly average was considered. Moreover, some instruments had missing readings, in these cases; interpolations were performed through temporal series, meaning that, an adequate model was established from the Box & Jenkins methodology, using the Statgraphics [13]. In this way, it was possible to assure that all the 120 instruments had 120 readings (10 years). See [14] for more information about the interpolation techniques with temporal series.
In this way, the Matrix of entrance of structural geotechnical instrumentation data (Matrix
During the period of the Multivariate Analysis was applied and the patterns were grouped through the Ward’s hierarchical clustering method. The grouping was performed in order to find out similar groups of instruments, and the aim of doing it was to establish the technical justifications for its formation. In addition, the Factor Analysis was applied to the referred data. The Factor Analysis was used to rank the rods of the extensometers through a balanced average of factor scores. Next, the Factor Analysis was applied within each group formed by the clustering analysis. Once having groups that have the instrumentations with a similar behavior, a raking of these instruments was performed within each group, in order to indicate the most relevant instruments, which would be chosen, for example, in cases of intensifying the reading.
Factor Analysis is a multivariate statistical method, which objective is to explain the correlations between one large set of variables in terms of a set of unobserved low random variables called factors. Hence, suppose the random vector
The covariance matrix of the vector X can be placed in an exact form: V(X) = = LL‘ + , where matrix LL’ has on the main diagonal the called communality defined for each variable considering m factors by: h
There are many criteria to define m number of factors. The most used one is the Kaiser criterion [15], which suggests that the number of extracted factors must be equal to the number of eigenvalues higher than one, of Σ or ρ.
If X is a random vector, with p components, and the parameters E(X) = e V(X) = , in factor model ortogonal, X is linearly dependent upon several random unobserved variables, F1, F2,..., Fm called common factors and p sources of joining variables: ε1, ε2,..., εp, called errors or specific factors.
The model of Factor Analysis is represented below, where μi is the average of the i-th variable, εi is the i-th error, or specific factor, Fj is the j-th common factor and lij is the weight of the j-th Fj factor on i-th Xi variable. Equation 1 shows the model represented in matrix terms.
In order to estimate the loading lij and the specific variables ψi, the method of principal components can be used, which is briefly described below [15].
If the pair of eigenvalues and eigenvectors are (λi, ei) of the matrix of sample covariance S, with λ1 ≥λ2≥... ≥λp≥ 0 and m<p is the number of common factors the matrix of the estimated loadings is given by L = CD1/2, where C is the matrix of the eigenvectors and D is a diagonal matrix of which the diagonal elements are the eigenvalues.
In the application of this method, the observations are primarily centralized or standardized, in other words, the matrix of correlation R (estimator of p) is used in order to avoid problems of scale. The specific variances estimated
In multiple actions, it is necessary to estimate the value of the scores of each factor (unobserved) for an individual X observation. These factor values are called factor scores. The estimated factor scores to the original variables are F = (L\'L)-1 L\'(X –
According to [15], with the rotation of factors, a structure is obtained for the low or moderated loadings on the other factors. This leads to a more simplified structure to be interpreted. Kaiser suggested an analytical measure known as Varimax criteria [15] in order to make the rotation.
The rotation coefficient scaled by the square root of the communalities is defined by
In Factor Analysis, communality
To perform the ranking of the variables (instruments), a final factor score was used, which is given by equation (3), where m is the number of factors extracted, λi are the eigenvalues and f
The Factor Analysis was done with the aid of the computational Statgraphics [13].
The clustering is a manner of grouping in a way that those patterns inside the same group are very similar to each other, and different from patterns of the other groups. According to [16], cluster analysis is an analytical technique used to develop meaningful subgroups of objects. Its objective is to classify the objects in a small number of groups that are mutually exclusive. According, to [17], it is important to favor a small number of groups in cluster analysis.
The clustering algorithms can be divided into categories in many ways, according to its characteristics. The two main classes of clustering are: the hierarchical methods and the nonhierarchical methods.
The hierarchical methods include techniques that connection of the items assuming obtain various levels of clustering. The hierarchical methods can be subdivided into divisive or agglomerative ones. The agglomerative hierarchical method considers at the beginning each pattern as a group and interactively, clusters a pair of groups that are the most similar with a new group until there is only one group containing all patterns. In the other hand, the divisive hierarchical method, starts with a single group and performs a process of successive subdivisions [18].
The most popular hierarchical clustering methods are: Single Linkage, Complete Linkage, Average Linkage and Ward’s Method. The most common method of representing a hierarchical cluster is using a dendrogram that represents the clustering of the patterns and the levels of similarity in which the groups are formed. The dendrograms can be divided in different levels, showing different groups [19].
In the dendrogram (figure 6), two groups can be seen by admitting a cut on the level represented by the figure. The first one composed by patterns
Example of dendrogram.
Methods that are not hierarchical or partitioning seek for a way of partitioning without the need of hierarchical associations. Optimizing some criteria, a partition of the elements on
The most known method among the nonhierarchical methods is the
The methods of the Multivariate Statistics field were used because these are already common methods. The Multivariate Statistic Analysis is an old method that has been made feasibly recently with the advance of present, fast and economic computation.
The clustering of the patterns is based on the measure of similarity and dissimilarity. The similarity measure evaluates the similarities of the objects, in other words, the highest the measures value are the most similar are the objects. The most known mean of similarity is the correlation coefficient. The means of dissimilarity evaluates whether the objects are dissimilar, this is to say, that the highest the measure value are the less similar the objects are. The most known measure of dissimilarity is the Euclidean distance.
According to [15], Ward’s method performs the join of two clusters based on the “loss of information”. It is considered to be the criteria of “loss of information” the sum of the error square
For each pair of cluster
The clusters
Cluster Analysis was applied with the aid of the computational software
This research was performed during the first author’s (Rosangela Villwock) doctorate process, from 2005 to 2009, in the Post-graduation Program on Numerical Methods in Engineering, of the Federal University of Paraná, guided by the second author of this text (Maria Teresinha Arns Steiner). This study was part of a project guide by the third author (Andrea Sell Dyminski), called “
As mentioned before, the aim of this paper is to identify the instruments that are the most significant to the analysis of the behavior of dams. There are no records of the existence of methods that perform the ranking of the instruments of monitoring dams. In order to achieve this aim, it is necessary to select, cluster and rank geotechnical-structural instruments of an electric power plant looking forward to maximizing the effectiveness and efficiency of the readings analysis, in our case the Itaipu Hydroelectric Power Plant. In case of needing to intensify the reading this hierarchy could be useful to define which instruments to choose.
The choice of instrumentation is performed with no previous knowledge about the location, features, or characteristics of the instruments. In this way, it is possible to think of applying the methodology when making decisions about the automation of the additional instruments. Approaches that are similar to this can be used in many other cases because there are hundreds of large Civil Engineering construction works that rely on systems of instrumentation in Brazil which the data must have an appropriate treatment.
In the cluster Analysis, the patterns are the rods of the extensometers, and its readings along the months which are compared in order to determine the clusters. The dendrogram on figure 7 shows the formation of the clusters for these data.
Considering the first cut, there are two clusters left. The first cluster, here denominated “cluster 1”, is formed by the rods of the extensometers that are considered extremely important to the monitoring of the dam. They are rods of extensometers installed in the axis of the block upstream the dam and inclined 60º towards upstream.
Notice that there is a formation of two additional clusters in the second cut. The first one denominates “cluster 2” which most of its rods of the extensometer installed in the balsatic rocks B, C and D (A and B are called the deepest rocks; C and D are called the superficial rocks), and on the lithological contacts B/C and C/D. The second cluster, denominated “cluster 3” has most of the rods of the extensometers installed in the joints (between the rock layers) A and B and on the lithological contact A/B.
This was the quantity of clusters which are been considered (3 clusters), since it was possible to obtain technical justification for its formation. In a larger subdivision, such justification was not observed.
Notice that at this point it was possible to cluster the instruments according to the relevant geological characteristics of the foundation mass, even though they weren’t explicitly showed to the technician. However, on cluster 2, three rods of extensometers installed in joint B were observed, and in cluster 3, three rods of extensometers installed in the basaltic rocks B and C and in the lithological contact B/C were observed.
Dendrogram showing the formation of the clusters in different types of cuts (Ward’s method).
Figure 8 shows the graphic of all the rods of the extensometer during the period of study. The lines were colored according to the cluster of which the rods belong to (black, blue and yellow for clusters 1, 2 and 3, respectively). It is possible to note the distinction between the clusters. This distinction of clusters is not easily recognized when there is no previous knowledge about these three clusters. The task would not be possible if a larger cluster of data hat to be analyzed, hence, the importance of this type of analysis.
Cluster 1, which is composed by rods of extensometers installed on the upstream of the dam, clearly shows the effects of summer and winter. The clusters 2 and 3 are separated due to the absolute measures. This separation can be justified by the fact that they are indifferent conditions, which is more superficial in cluster 2, and deeper in cluster 3. Once the readings of the most superficial rods and the readings of the deepest rods are summed up, these measures are larger.
Table 2 shows the most important rod for each of eight factors, for instances, the rod dominating each factor. Notice that in table 2 the factor 2 is dominated by the rod equip1_1, equip1_2, equip4_1, equip4_2, equip6_1, equip6_2, equip8_1, equip8_3, equip21_1, equip21_2, equip25_3, equip26_2 e equip31_1. This factor has 10 of the 11 rods that are part of cluster 1, it means that there is an external phenomenon influencing them. As mentioned before, these rods reflect the effects of the summer and winter. In the same way, each factor is dominated by a set of rods and there is an external phenomenon that explains each set of rods or factor, even though it is not easy to interpret them.
Graphic of all rods of the extensometers from the period of study.
factor1 | equip7_1 | equip7_2 | equip7_3 | equip11_1 | equip12_1 | equip12_2 | equip13_1 |
equip13_2 | equip14_1 | equip14_2 | equip14_3 | equip19_2 | equip20_2 | equip20_3 | |
equip22_1 | equip22_2 | equip22_3 | equip23_1 | equip23_2 | equip23_3 | equip24_1 | |
equip24_2 | equip24_3 | equip25_1 | equip25_2 | equip27_2 | equip28_1 | equip28_2 | |
equip29_1 | equip29_2 | equip32_3 | equip33_1 | equip33_2 | equip33_3 | equip34_1 | |
equip34_2 | equip34_3 | equip35_1 | equip35_2 | ||||
factor2 | equip1_1 | equip1_2 | equip4_1 | equip4_2 | equip6_1 | equip6_2 | equip8_1 |
equip8_3 | equip21_1 | equip21_2 | equip25_3 | equip26_2 | equip31_1 | ||
factor3 | equip2_1 | equip2_2 | equip3_1 | equip3_2 | equip5_1 | equip5_2 | |
factor4 | equip13_3 | equip18_1 | equip18_2 | equip18_3 | equip19_1 | equip19_3 | |
factor5 | equip15_1 | equip15_2 | |||||
factor6 | equip8_2 | equip20_1 | equip32_2 | ||||
factor7 | equip26_1 | ||||||
factor8 | equip32_1 |
Rods of extensometers that are important to each factor, according to its weights in the Factor Analysis.
A community is the portion of the variation of the extensometer rods which is explained by its factors. A low community within a rod indicates that the same is not greatly affected by the factor because a community is the sum of contributions of each rod in each square factor. Thereon, in this case the influence mainly comes from a random factor. Notice that none of the extensometer rods showed lower community than 0.71, it means that none of the random variations are over 29%. A community that is equal to 0.71 indicates that the 71% of the rods extensometer variations is ascribed to the factors and that only 29% of those variations is random, it means that these correlated rods are working properly. A low community would indicate a need of investigating the rods.
Table 3 shows 25 rods of extensometers with the highest communalities. In case of reading intensification, these rods are the recommended ones. The highlighted rods are part of the system of automatic data acquisition of Itaipu. 24 of the 74 rods that were analyzed were automated by the engineers’ team of Itaipu. The method of ranking that was proposed (without the previous clustering of the rods) indentified 14 of the 24 automated rods.
Communality | 0,988861 | 0,981763 | 0,976523 | 0,975655 | 0,972231 | 0,971971 |
Rod | equip29_1 | equip21_2 | equip23_1 | equip22_1 | equip3_1 | equip1_1 |
Communality | 0,971798 | 0,970804 | 0,970397 | 0,968213 | 0,968083 | 0,967029 |
Rod | equip22_3 | equip11_1 | equip1_2 | equip23_2 | equip4_1 | equip21_1 |
Communality | 0,966632 | 0,965999 | 0,965522 | 0,964925 | 0,963139 | 0,960121 |
Rod | equip4_2 | equip29_2 | equip34_3 | equip6_1 | equip6_2 | equip22_2 |
Communality | 0,957609 | 0,953036 | 0,950395 | 0,949394 | 0,949108 | 0,948646 |
Rod | equip14_3 | equip25_1 | equip33_2 | equip24_2 | equip24_1 | equip5_1 |
Communality | 0,943644 | |||||
Rod | equip28_1 |
Shows the 25 rods of extensometers with the highest communalities.
After forming three clusters, the ranking of the rods was performed within each cluster with the help of the Factor Analysis. The hierachization within each group can also be used to identify rods used on readings intensification. The advantage of application of ranking within each group is that a separation of the rods with similar behavior is firstly obtained then the indicated rods will well represent the variability of the cluster. Note that the rods of the automated extensometers are, mostly, among the first in the ranking of each cluster.
As mentioned above, a low communality of a rod indicates that this rod is not strongly influenced by the factors and, in this case, the influence comes from random factors. In the application of Factor analysis within each cluster, there are rods of extensometers with communities between 0,6 and 0,7, in other words, random variation between 30% and 40%. It is indicated that the investigation on the rods is performed in this case.
Furthermore, in order to identify the 24 rods that are the most relevant, we opted, in first place, to identify the 8 best ranked rods from each cluster. In this case, there would be 15 out of the 24 automated rods. This number of rods coinciding with the automated ones in Itaipu would increase with the aid of a specialist for a better interpretation of the results. This specialist would detect that cluster 1, for example, is formed by rods that are extremely important for the monitoring of dams, and that all rods from this cluster should be automated.
This type of analysis was not found in literatures, for this reason the contribution of this study is relevant. It is recommended that this Analysis (process of hierarquization) is repeated periodically (according to the needs indicated by the specialists in this field – in this case, by the engineers’ team of Itaipu) what could be done, for example, every two years. This can show the appearance of new rods that are indicated by the performing of readings intensification (that should be investigated), the same could occur with rods that would no longer be indicated.
When there are rods within the clusters with low communalities, it is recommended that they are investigated. Low communality indicates a high percentage of randomness in the data and that can be an indicator of problems with the rods.
These identifications of similar rods can also be used in projecting the control values. In this case, the values of control for each rod can be associated to the readings of the rods that belong to a same cluster.
The final factorial score performs the hierachization of the attributes. In this case the patterns are vectors of which the components (attributes) are the readings of the rods of the extensometers in a certain month. Therefore, the final factorial score performs the hierachization of the months showing whether there is any month that is rather relevant and that deserves greater attention.
Table 4 shows the first 15 months with a higher final factorial score and the last 15 months with lower final factorial scores, considering the 72 rods of extensometers. The values of the 15 first months with a higher final factorial score reveal that all the months are important; there is no month that is rather relevant. Only the month of December does not appear in the first 15 months. Notice that 1995 was the most relevant year and in analyzing the ambient temperature during the period of study it was possible to verify that this occurred due to the high temperature variation. The values of the last 15 months with least final factorial scores revealed that the months of April, May, and June are the most important one, identifying the effects of summer.
As mentioned, cluster 1 shows the effect winter/summer in its readings. For this reason the final factorial score was calculated in order to perform a ranking of the months for cluster 1, to show whether there is any month or some months with greater relevance.
The first 15 months with a higher final factorial score and the last 15 months with least final factorial scores were observed considering only the 11 rods of the extensometer of cluster 1. The values of the 15 first months with higher final factorial scores reveal that the months of September, October, and November are the most relevant ones, identifying the effects of winter. The values of the last 15 months with least final factorial score reveal that the months of March, April, May and June are the most important ones, identifying the effects of summer.
The identification of the months with more significant readings for an external effect (in this case, the effect of summer and of winter on the readings of the rods of the extensometers), can be useful, for example, in the projection of the values of control. Admitting that there are differences in the readings of the rods for the months related above, only the readings performed in these months would be used to define specific values of control for these months.
15 first | 15 last | ||
Final factorial score | Month | Final factorial score | Month |
1,755 | January/98 | -0,761 | April/02 |
1,217 | August/95 | -0,816 | July/03 |
1,153 | January/95 | -0,821 | Febrary/03 |
1,091 | Febrary/95 | -0,821 | June/00 |
0,992 | June/95 | -0,856 | June/02 |
0,914 | March/95 | -0,877 | May/03 |
0,902 | April/95 | -0,904 | Febrary/00 |
0,877 | November/96 | -0,924 | May/00 |
0,794 | May/95 | -0,934 | May/02 |
0,781 | July/95 | -0,965 | April/00 |
0,776 | April/97 | -0,971 | April/04 |
0,749 | October/95 | -1,050 | April/03 |
0,741 | November/95 | -1,061 | June/03 |
0,710 | September/95 | -1,135 | May/00 |
0,709 | Febrary/96 | -1,152 | March/03 |
Shows final factorial scores of the months in which the readings of the 72 rods of the extensometers were performed.
The application of this methodology is suggested for other instruments and other periods, and the implementation of it in order to define values of control and for anomaly detection. Once the process of ranking is repeated in several periods (every 2 years, for example.) it can show the appearance of new rods which are indicated for performing readings intensification or the appearance of rods that could no longer be indicated (these should be investigated).
This manuscript shows a methodology that uses some techniques of the field of Multivariate Analysis, which aim is to select, cluster and rank geotechnical-structural instruments of a Hydroelectric power plant, in our case, the Itaipu hydroelectric power plant, in order to maximize the efficiency and effectiveness of the analysis of the readings.
The methodology showed was applied to the instruments called extensometers, locates in different points of block F of the dam, a total of 30 extensometers that with one, two or three point rods totalized 72 measures of monthly displacement. This measures were stored over a period of 10 years, totalizing 120 readings (January/1995 to December/2004). It is important to remember that 24 measures out of the 72 were automated by the company. The ranking of the instruments would be a way to choose the instruments without any previous knowledge about its location, features, or other characteristics. In this way, it is possible to think in applying this methodology in further decision-making when it relates to the automation of additional new instruments.
The methodology used to analyze the problem of the research was composed by the following form: Ward’s method was applied in order to cluster 72 rods of extensometers; at the same time, the Factor Analysis was applied in order to rank the rods; latter, the Factor Analysis was applied within each cluster formed by Clustering Analysis.
In the Factor Analysis applied to the 72 rods, there was not need of investigation for any of the rods, once the communality was high for each of them. Observing the 25 rods of extensometers with the highest communality, 14 rods were identified among the ones that were automated by the team of engineers of Itaipu (the automated rods are the ones considered the most important), in other words, the proposed hierachization method (without previous clustering of the rods) identified 14 of the 24 automated rods.
The Clustering Analysis shows that it is possible to find technical justification for the formation of three clusters. The instruments were clustered according the relevant geological characteristics of the foundation mass, although they were not explicitly shown to the technicians.
By Observing the clusters 1, 2, and 3, the factor analysis was applied within each cluster in order to perform the ranking of the rods of the extensometers. It was possible to notice that the rods of the automated extensometers are, most of the time, among the first ones of the ranking of each cluster.
In order to identify the 24 rods that are the most relevant, we decided to identify the 8 best ranked rods from each cluster. In this case, there would be 15 of the 24 automated rods. This number of rods coinciding with the automated ones in Itaipu would increase with the aid of a specialist for a better interpretation of the results. For instance, this specialist would detect that cluster 1is formed by rods that are extremely important for the monitoring of dams and that all rods from this cluster should be automated.
Approaches that are similar to this can be used in many other cases, since there are thousands of large construction works of Civil Engineering that use the system of instrumentation, of which the data can and must receive an appropriate treatment.
The approach of an important problem of engineer, the analysis of the instrumentation data of large construction works, clustering techniques and other techniques were applied, in the context of the Multivariate Statistical Analysis, aiming the identification of the instruments that are the most significant ones to the analysis of the behavior of dams.
The authors would like to thank Itaipu’s Civil Engineering team for instrumentation data and technical contributions.
“Once one starts to think about the human welfare consequences of economic growth, it is hard to think about anything else” [1]. Economic growth is the basis for increased prosperity, and its importance cannot be overstated. Barro and Sala-i-Martin [2] argue that continuous and sustained economic growth is important for improving the welfare of individuals and that aggregate growth is probably the single most important factor affecting individual levels of income. Due to the importance of economic growth, attainment of high economic growth rates is a major national objective of any country. It is, however, puzzling and at the same time worrisome that the riches of the world are so unequally shared among countries [3].
Over the years, growth performance has varied notably across regions and countries. In some economies, it has experienced major shifts over time. A few developing countries have experienced rapid growth yet some other countries have grown at only a stagnant rate. This discrepancy in economic growth among numerous countries and the dynamics of growth have become provocative research targets. The main questions are why some countries are rich while others are poor, and what determines the rate of growth? Rosa notes that it seems certain that there is no all-encompassing theory of economic growth, but different sources of economic growth can be observed to be relevant for different stages of economic development.
Several reasons have been provided that explain the differences, key among them being the fact that initial conditions differ greatly. Isaksson [4] asserts that some, if not many, of the differences in income per capita are human-created. He asserts that how a society and its production are organized can significantly explain the observed income divergence since the industrial revolution.
In the case of Uganda, the last five decades have been difficult in terms of overall economic growth and stability, let alone the first eight years after independence and the last three decades, when episodes of high yet unstable economic growth occurred, especially from the late 1980s to the late 2000s. Economic growth was impressive for the first eight years after independence, but by 1986, the economy had descended into a deep recession owing to poor governance from the early 1970s to that time. Since 1986, the country has undergone a major transformation from a “failed state” to one of the fastest-growing economies in the world. As early as 1993, Uganda started implementing structural adjustment programmes (SAPS) and other economic policies and programmes such as; economic recovery programme (ERP), medium-term expenditure framework, Plan for Modernization of Agriculture (PMA), and Poverty Eradication Action Plan (PEAP), among others all aimed at poverty reduction and attaining higher levels of economic growth in Uganda. The reforms ushered in relatively high economic growth rates based on incentives for private production. Between 1990 and 2010, GDP growth averaged 7.3 percent per annum, placing Uganda among the fastest-growing economies in the world and creating momentum for take-off. This growth was higher than the Sub-Saharan African growth rate, which averaged approximately 2.1 and was close to that of the East Asian and Pacific region of 7.9 and 6.6 percent, respectively.
To consolidate and accelerate this growth process, the Ugandan government approved the Comprehensive National Development Planning Framework Policy in 2007 which provided the developmental agenda for a 30-year vision to be implemented through three 10-year plans and six 5-year national development plans (NDPs), among other operational plans. However, data shows that Uganda’s growth has been mostly unstable; it has been described as unsustainable because it has been sustained partly by significant aid inflows and only a few tradable commodities, such as coffee, flowers and fish. The government of Uganda, like many other governments elsewhere continues to target improving GDP growth. The key to achieving this improvement has been the careful development and implementation of policies and programmes to improve capital stock, labour stock, price stability and productivity and competitiveness as major drivers of economic growth [5].
Uganda has set its Vision 2040 as a guiding framework for transforming the country from “a peasant to a modern and prosperous country with a per capita income of USD 9,500 from the base figure of USD 506 in the year 2010 by the year 2040”. For the country to achieve this transformation, Uganda Vision 2040 projects that Uganda’s real GDP will have to grow at an average of 8.2 percent, while the IMF forecasts approximately 9 percent growth rate as necessary for the remaining period. However, the achievement of Vision 2040 has been threatened not only by lower-than-targeted rates of annual GDP growth since the inception of the vision but also by a recent slump from the average GDP growth rate of approximately 6.8 percent that was posted in the last half of the 2000s to an average of 4.6 percent between 2010 and 2015.
To achieve the Vision, understanding the determinants of past growth, removing the constraints on present growth and maximizing the prospects for future growth are key. It is important to note that inferring the determinants of growth faces considerable uncertainty due to the existence of multiple overlapping theories that emphasize different channels of growth over time. Therefore, this paper aims at providing more robust and targeted policy interventions to generate higher and more sustainable economic growth by examining the determinants of economic growth in Uganda using the ARDL frameworks.
A wide range of studies have investigated the factors underlying economic growth in different countries. Using differing conceptual and methodological viewpoints, studies have identified different factors that explain economic growth world over [6]. However, existing literature has not yet reached a consensus about a typical set of variables that may affect economic growth.
The accumulation of physical capital (investment) is one of the most fundamental determinants of economic growth identified in the literature per the neoclassical and endogenous growth models and much empirical work has been performed on the subject [7, 8, 9]. It has been found to be robust to most specifications and sample size changes [10]. The impact of several types of investment has been studied over time and varying levels of significance have been attached to varying types of investment. Gross capital formation affects economic growth by either directly increasing the physical capital stock in the domestic economy [11] or indirectly promoting technology [12]. Other researchers have investigated the impact of private and public investment on economic growth and have found significant variations. Khan and Kumar [13] found private investment to be more productive than public investment. In this paper, investment is represented by physical capital accumulation and it is expected to have a positive and statistically significant relationship with economic growth.
Exports are another factor identified by both the neoclassical and endogenous growth models in explaining economic growth variations. Awokuse [14] notes that linking exports to economic growth is pied when he found that there is a flow of Granger cause from real exports to real GDP. There is also a strand of studies that find no conclusive evidence of the causal relationship between exports and GDP growth. Ruiz-Nápoles [15] argues that even in cases where increasing exports has a positive effect on production expansion, such an effect may be limited and offset by increasing manufacturing imports displacing domestic production. Fouad Abou-Stait [16] found that time series studies find fewer conclusive associations between exports and growth, whereas cross-sectional studies appear to support the positive relationship.
Closely related to exports is trade openness with mixed results. A large part of the literature find that economies that are more open grow more rapidly [17, 18, 19, 20]. Baliamoune [21] finds that trade openness is closely associated with positive effects in higher-income and negative effects in lower-income African countries. Arezki and Gylfason [22] find that trade openness has a positive and statistically significant impact on non-resource GDP growth. Several scholars have however criticized the robustness of these findings, especially on methodological and measurement grounds (see, [23, 24]). Vamvakidis [24] and Wong [25] find a negative relationship between openness to international trade and economic growth. Fowe finds no significant effect of openness to trade on economic growth in SSA.
Several endogenous growth models and extensions of the neoclassical growth model find human capital and/or knowledge to be a major source of growth [26]. A large number of studies find evidence suggesting that an educated population is a key determinant of economic growth (see [8, 27, 28]). However, other scholars find mixed results while others question studies that have found a positive relationships [29, 30]. Some empirical findings have shown that human capital accumulation plays only a small role in economic growth [31]. Studies by Bils and Klenow [32], Pritchett [29], Easterly and Levine [33] found that the evidence was weak, absent or even pointed to a negative impact.
Population growth rate is another important variable in economic growth literature. The relationship between population and economic growth is mixed and varies between countries [34]. Some empirical studies have found a negative relationship between population and economic growth [35, 36]; and in others there was a positive association with economic growth [37, 38]. Another factor influencing economic growth is population growth rate [36, 39, 40]. High population growth, for example, could have a negative impact on economic growth, influencing the dependency ratio, investment and saving behavior and quality of human capital countries [41]. However, the findings are again inconclusive since there some studies have reported no (strong) correlation between economic growth and demographic trends (e.g., [29, 42]).
Foreign Aid has received renewed political interest in economic growth discourse resulting into numerous studies. There is however little evidence of a significant positive effect of aid on the long-term growth of poor countries [43, 44]. Andersson and Karlsson, C. [45] finds support for the basic idea that an increase in aid flows strengthens economic growth in poor countries when the policy environment is conducive. Collier and Dehn [46] find that well-timed aid alleviates effects of negative export shocks while Collier and Hoeffler [47] find that aid works particularly well in good policy environments a few years after a conflict has ended. Other scholars argue that aid spurs economic growth unconditionally (see, [37, 48]), or in certain macroeconomic environments that it is growth-neutral [49]. In contrast, some studies have argued that aid has historically been ineffective in promoting growth [50, 51]. Rajan and Subramanian [43] provide evidence that total aid is ineffective at promoting growth.
The relationship between government consumption expenditure and economic growth has attracted a great deal of interest among policymakers and economists. Empirical work on this subject has also provided mixed results. On one side, there are Keynesian economists who consider consumption expenditure as a dependable function of income and on the other side there are substantial numbers of economists who believe that higher consumption can stimulate economic growth [52, 53]. Other studies have found that small to moderate government sizes are positively associated with economic growth while large government sizes impede economic growth [54, 55].
It is argued that inflation is a good macroeconomic indicator of how the government manages the economy [55, 56, 57]. Although the empirical evidence has strongly supported a negative relationship between inflation and growth, especially through the impact of inflation on capital intensity [58], other studies have found that inflation exhibits threshold effects on economic growth [59, 60]. Khan and Senhadji, [60] explore this issue and reach several conclusions. In particular, medium and high inflation hamper economic growth due to the adverse impact on the efficient distribution of resources by changing relative prices [57].
Based on the foregoing literature, we assume a Cobb–Douglas production function with labour-augmenting (Harrod-Neutral) technological progress following Mankiw, et al. [27] and Acikgoz and Mert [61].
where
where HC is human capital, and all other variables are defined as before. Following Mankiw, et al. [27], Acikgoz and Mert [61], and Chirwa and Odhiambo [17], the aggregate Cobb–Douglas production function is assumed to take the following form:
where α and β represent the partial elasticity of output with respect to physical capital and human capital respectively. Per the literature, technological progress (
Several efficiency variables have been identified in the literature to provide a link to how policy variables influence the aggregate production function [55, 57]. The variables selected for this study consist of the accumulation of physical capital (investment); human capital (total school enrolment); population; and policy variables (efficiency factors) that include government consumption share in GDP, inflation, foreign aid as a share of GDP and international trade. The efficiency factors, similar to population growth, are assumed to grow exogenously (see [27, 62]).
Auto Regressive Distributed Lag (ARDL) bounds testing approach developed by Pesaran and Shin [63], Pesaran, Shin and Smith [64] was employed. The modeling approach allows us to capture the short and long run dynamics as well as the speed of adjustment between the independent variables and the dependent variable. The embedded Error Correlation Model (ECM) is a restricted representation that has cointegration restrictions built into the specification so that it is designed for use with non-stationary series that are known to be cointegrated. The ECM specification restricts the long run behavior of the endogenous variables to converge to their cointegrating relationships while allowing a wide range of short run dynamics. Choice of the ARDL model was taken based on the following reasons: (1) the variables were found to be integrated of different orders i.e. (I(0) and I(1) and ARDL can be applied even when variables are not integrated of the same order; (2) ARDL performs better than other co-integration tests in small and finite data samples [65]. The two stage ARDL approach effectively corrects for any possible endogeneity in the regressors [61, 66]; (3) According to [67, 68] the ARDL model also allows for different optimal lags among the different variables to capture the data-generating process as a general-to-specific modeling framework [68, 69], (4) ARDL is known to have information about the structural break in time series data and lastly Pesaran and Shin [63] contented that appropriate modification of the orders of the ARDL model is sufficient to simultaneously correct for residual serial correlation and the problem of endogenous variables. The only drawback being that ARDI approach collapses when variables are integrated of order two (i.e I(2)).
The ARDL representation of the empirical model for this study is expressed as follows:
where
Two steps are involved in estimating an ARDL model. First, the long-run equilibrium relationship between the variables is tested using the upper and lower bounds; then, the short-run and long-run causalities are estimated. The ARDL bounds test is based mainly on the joint F-statistic in which its asymptotic distribution is non-standard under the null hypothesis of no co-integration [70].
In Eq. 4 above, the null hypothesis of no co-integration relationship, defined as
Using the Wald test, the computed F-statistic is then compared with the lower and upper asymptotic critical bounds values, as reported in Pesaran et al. [64]. The lower-bound critical value assumes that all the regressors are l(0), while the upper-bound critical value assumes that they are I(l). We reject the null hypothesis of no co-integration if the computed test statistic exceeds the upper-bound critical value, and we do not reject the null hypothesis if the F-statistic is lower than the lower-bound critical value. The test is, however, inconclusive if the computed F-statistic lies between the lower-bound and upper-bound critical values. In this context, unit root tests should be conducted to ascertain the order of integration of the variables. If all the variables are found to be I(1), then the decision is made on the basis of the upper-bound critical value. On the other hand, if all the variables are I(0), then the decision is based on the lower-bound critical value. To test for the long-run relationship between the variables, we exclude the lagged-level variables from Eq. (4). Once the presence of co-integration is confirmed, we estimate the long-run coefficients of the growth model and the associated ARDL of the ECM for the short-run coefficients.
The ARDL method estimates (p + 1)k number of regressions to obtain the optimal lags for each variable, where p is the maximum number of lags to be used and k is the number of variables in the equation [71]. The model is selected based on the Schwartz-Bayesian criterion (SBC) or the Akaike information criterion (AIC).
ARDL estimation provides both the short run (model) and long run estimation results. The ECM is specified as follows:
where
Annual time series data for the period 1982–2015, that was obtained from World Bank Development Indicators [73, 74] was used in this study. The following variables were used: Real GDP (expressed in 2010 U.S. dollars.) at purchaser’s prices; Investment (proxied by gross fixed capital formation as a share of GDP); Inflation (measured by the consumer price index); General government expenditure as a share in GDP (General government expenditure as a share in GDP); Human Capital (representing knowledge spill over effects) was proxied by Human capital index3, based on years of schooling and returns to education); Demography (proxied by total population); Trade openness (measured by the sum of exports and imports as a proportion of GDP); and Foreign Aid as a proportion to GDP (measured by net official development assistance and official aid received as a share of real GDP). Eviews 9.5 software was used to conduct the empirical analysis.
Unit roots/stationarity tests were conducted because this is a prime requirement for any co-integration and causality tests. The augmented Dickey-Fuller test (ADF: [75]) was used to establish the order of integration. The ADF test results were augmented with the Phillips-Perron (PP: [76]) test. Table 1 presents the results of the unit root tests.
Variables | Augmented Dickey Fuller | Phillips-Perron test |
---|---|---|
Constant + trend | Constant + trend | |
Log Real Gross Domestic Product | −3.48* | −3.48* |
Log Trade Openness | −2.81 | −2.62 |
Log Human Capital | −2.84 | −2.26 |
Log Population Growth | −0.06 | −1.72 |
Log Gross Government Final Consumption (% GDP) | −1.77 | −1.71 |
Log Gross Fixed Capital Formation | −3.95** | −2.89 |
Log Inflation Rate | −5.28*** | −2.22 |
Log Aid | −2.24 | −2.18 |
Log Total School Enrolment, Primary | −1.85 | −1.74 |
Log Imports | 3.41* | −2.43 |
Log Exports | −2.86 | −3.21 |
Log Real Gross Domestic Product | −3.38* | −3.38* |
Log Trade Openness | −4.51*** | −4.37*** |
Log Human Capital | −3.80 | −3.85* |
Log Population Growth | −3.80** | −2.35 |
Log Gross Government Final Consumption (percent) GDP) | −4.92*** | −6.02*** |
Log Gross Fixed Capital Formation | −4.33*** | −5.24*** |
Log Inflation Rate | −2.05 | −2.30 |
Log Aid | −6.41*** | −7.56*** |
Log Total School Enrolment, Primary | −6.91*** | 7.08*** |
Log Imports | −3.77** | −3.40* |
Log Exports | −6.49*** | −6.49*** |
Unit root test at level and in first difference.
***, **, and * denote rejection of the null hypothesis of unit root at the 1 percent, 5 percent and 10 percent significance levels, respectively.
The ADF test results with trend and intercept at level in part A indicate that GDP, GGC, and GFCF were stationary at the 5 percent level of significance, whereas CPI was stationary at the 1 percent level of significance. The researcher thus carried out stationarity tests for all series in first difference with constant and trend, as indicated in part B (ADF test), and the variables, except CPI, became stationary.
The variables were also tested for stationarity using the Phillips-Perron test. The PP test results at level with constant and trend were found to be non-stationary except for GDP and GGC, which were found to be stationary at 10 percent and 5 percent levels of significance, respectively. The variables were tested for stationarity in first difference, and they all became stationary except CPI.
We tested for co-integration among the variables to establish whether they had a long-run relationship. From a statistical point of view, a long-run relationship implies that variables move together over time and that short-term disturbances arising from the long-term trend are corrected. Co-integration is necessary because a valid ARDL requires the presence of a co-integrating set of variables. The ARDL method allows us to test both short- and long-run relationships between the dependent and independent variables in a multivariate framework. The critical value bounds are computed by stochastic simulations using 20,000 replications [66].
The variables are jointly tested if they are equal to zero. That is:
H0: They are jointly equal to zero.
H1: They are not jointly equal to zero.
Once the test statistic is computed, it is compared to two asymptotic critical values corresponding to polar cases of all variables being purely I(0) or purely I(1). When the test statistic is below the lower-bound critical value, the null hypothesis is not rejected, and co-integration is not possible. In contrast, when the test statistic is above the upper-bound critical value, the null hypothesis is rejected, and co-integration is indeed possible. Alternatively, should the test statistic fall between the lower-bound and upper-bound critical values, the test results are inconclusive, and knowledge of the co-integration rank is required to proceed further.
The Akaike information criterion was employed to determine the appropriate lag length for the estimated ARDL equation. This method was chosen because it tends to over-fit the model of interest, given that the optimal lag length for the growth model is up to 2 lags. The optimal lag length is chosen based on the number of dynamic regressors included in the model and the sample size. The optimal lag-length selection criteria are based on the lowest AIC obtained. For this growth equation, (regression I), the optimal ARDL model selected was the ARDL (2, 1, 0, 1, 0, 1, 0, 0, 2) model with restricted intercept and trend, while for regression II, the optimal ARDL model selected was the ARDL (2, 0, 2, 0, 1, 0, 0, 1, 0, 2) model with restricted intercept and trend. Table 2 reports the Pesaran et al. [64] bounds test for level relationships for the selected equation.
ARDL bounds test | Regression I | Regression II | ||
---|---|---|---|---|
Included observations: 32 after adjustments | ||||
Null hypothesis: no long-run relationships exist | ||||
Test statistic | Value | k | Value | K |
F-statistic | 5.47*** | 8 | 3.909** | 9 |
Critical Value Bounds | ||||
Significance | I0 Bound | I1 Bound | I0 Bound | I1 Bound |
10 percent | 1.95 | 3.06 | 1.88 | 2.99 |
5 percent | 2.22 | 3.39 | 2.14 | 3.3 |
2.5 percent | 2.48 | 3.7 | 2.37 | 3.6 |
1 percent | 2.79 | 4.1 | 2.65 | 3.97 |
R-squared | 0.845152 | 0.852168 | ||
Adjusted R-squared | 0.699981 | 0.672657 |
Results of ARDL bounds test for co-integration.
***, **, and * denote 1 percent, 5 percent and 10 percent significance levels, respectively.
As illustrated in Table 2, regression I, the computed 𝐹-statistic is 5.47, and it is statistically significant at the 1 percent upper-bound critical value, meaning that the null hypothesis of no co-integration is rejected at the 1 percent significance level. In regression II, the computed 𝐹-statistic is 3.909, and it is statistically significant at the 5 percent upper-bound critical value, meaning that the null hypothesis of no co-integration is rejected at the 5 percent significance level. In summary, the bounds test of co-integration relationships using the Pesaran et al. [64] approach confirms the existence of long-run level relationships between the dependent variable and the set of covariates in both regressions. The study results also reveal that the underlying ARDL model is a good fit, represented by an estimated
Using the ARDL model, the researcher selected the overall best model from the 20 best selected ARDL models. As shown in Figure 1, the selected model in regression I is ARDL (2, 1, 0, 1, 0, 0, 1, 0, 0, 2), and the selected model in the second regression is ARDL (2, 0, 2, 0, 1, 0, 0, 1, 0, 2). These two models were significantly superior to the second-best models in each case [66].
Relative superiority of the selected models.
The short and long run elasticities for the ARDL model were estimated. Table 3, part A presents the short-run ARDL results (including the ECM representation), while part B pre-sets the long-run results of the ARDL models.
ARDL co-integration and long-run form | ||
---|---|---|
Dependent variable: LRGDP | ||
Selected Model: Included observations: 32 | ARDL (2,1,0,1,0,1,0,0,2) | ARDL (2,0,2,0,1,0,0,1,0,2) |
Co-integration Form | Regression I | Regression II |
Variable | Coefficient(Prob.) | Coefficient (Prob.) |
D(Log Real Gross Domestic Product (−1)) | 0.179(0.049)** | 0.279(0.003)*** |
D(Log Trade Openness) | 0.036(0.190) | |
D(Log Population Growth) | 0.481(0.784) | 0.126(0.941) |
D(Log Inflation Rate) | −0.085(0.000)** | −0.086(0.000)* |
D(Log Human Capital) | 0.240(0.507) | 0.619(0.109) |
D(Log Gross Government Consumption) | 0.061(0.001)*** | 0.066(0.000)*** |
D(Log Gross Fixed Capital Formation) | 0.192(0.000)*** | 0.145(0.000)*** |
D(Log Aid) | −0.033(0.022)** | −0.021(0.111) |
D(Log Exports) | 0.027(0.047)** | |
D(Log Imports) | 0.056(0.178) | |
D(Dummy for Structural Adjustment) | −0.008(0.092)* | −0.018(0.007)*** |
C | 0.185(0.001)*** | 2.786(0.000)*** |
Coint Eq (−1) | −0.595(0.00)*** | −0.646 (0.000)*** |
Log Trade Openness | 0.295(0.002)*** | |
Log Population Growth | 1.008(0.090)* | 0.334(0.605) |
Log Inflation Rate | −0.009(0.624) | −0.018(0.361) |
Log Human Capital | 0.293(0.639) | 0.848(0.244) |
Log Gross Government Consumption (percent, GDP) | 0.198(0.001)*** | 0.159(0.007)*** |
Log Gross Fixed Capital Formation | 0.316(0.003)*** | 0.220(0.029)** |
Log Aid | −0.053(0.227) | −0.032(0.399) |
Log Exports | 0.121(0.007)*** | |
Log Imports | 0.090(0.244) | |
D(Dummy for Structural Adjustment) | −0.007(0.003)*** | −0.071(0.003)*** |
Short-run and long-run ARDL results.
***, **, and * denote 1 percent, 5 percent and 10 percent significance levels, respectively.
Part A of Table 3 reports the estimated short-run coefficients, while Part B reports the estimated long-run coefficients. Two different regressions were estimated. Regression I was the “benchmark” regression, while regression II was used for sensitivity/options analysis. Among other variables, regression II used a different proxy for trade openness, which is a fundamental variable for GDP growth, according to the literature. Specifically, instead of using trade openness, we used exports and imports to examine the effect of trade on GDP growth.
As shown in part A, the short-run dynamics and the adjustment towards the long-run equilibrium path are measured by the error correction term (ECT) [77]. In the short run, deviations from the long-run equilibrium can occur due to shocks in any of the variables in the model; thus, all the short-run coefficients show the dynamic adjustments of all variables to their long-run equilibrium [70]. If the coefficient is significant, it implies that past equilibrium errors play a role in determining the outcomes of the current period. The ECT measures the speed of adjustment to restore equilibrium in the dynamic model after a disturbance. For the coefficient to be significant, it is required that the error correction term (ECT) must be negative and significant. A highly significant ECT is further proof of a stable long-run relationship [78].
From Table 3, part A, regression I, the ECT estimation results show that the estimated coefficient of the error correction term has the expected sign (negative) and is statistically significant. This reinforces the finding of a long-run relationship in the co-integration equation. The results show that a 1 percent deviation from the equilibrium path is corrected in the next period at a rate of 59.5 percent and is statistically significant at the 1 percent significance level. This confirms the presence of a long-run level equilibrium path between real GDP and the selected regressors (trade openness, human capital, population, government consumption, investment, inflation, foreign aid and a policy dummy (structural adjustment programme). The regression results for the ARDL model reveal a good fit represented by an estimated
Part B, regression I of Table 3 presents the long-run coefficient estimates. The results reveal that the key macroeconomic determinants that are significantly associated with long-run economic growth in Uganda include trade openness, population growth, government consumption, investment, and the policy dummy variable for the structural adjustment programmes (SAPs).
In the long run, the relationship between trade openness and real GDP is positive and statistically significant at the 1 percent significance level. The results reveal that a 1 percent increase in trade openness in the long run leads to a 0.295 percent increase in the level of real GDP. These findings are supported by previous studies that have found a positive and significant relationship between trade openness and economic growth (e.g. [17, 19, 20]).
The study reveals that population growth is positively and significantly associated with the growth of real GDP in Uganda at the 10 percent level of significance. It shows that a 1 percent increase in population leads to a 1.01 percent increase in real GDP. These results are supported by similar studies conducted in developing countries that have found a positive relationship between investment and economic growth in the long run (e.g., [41, 79]).
The study reveals a positive relationship between government consumption and the growth of real GDP at the 1 percent significance level in the long run. A 1 percent increase in government consumption results in a 0.20 percent increase in the level of real GDP. These results are supported by similar studies conducted in developing countries that have found a positive relationship between government consumption and economic growth in the long run (e.g., [17]).
The results confirm the widely established empirical estimation finding that investment and growth in GDP have a positive relationship. A 1 percent increase in the level of investment results in a 0.32 percent increase in the level of real GDP. These results are supported by similar studies conducted in developing countries that have found a positive relationship between investment and economic growth in the long run (e.g., [10, 54, 80, 81, 82]).
The study results did not reveal a significant association between inflation, human capital and foreign aid and the long-run level of GDP growth.
The short-run results presented in Part A of Table 3 reveal that the key macroeconomic determinants that are significantly associated with the growth of real GDP in the short run are initial GDP, inflation, government consumption (percent of GDP), investment, foreign aid, and the policy dummy. The results show that a 1 percent increase in initial real GDP leads to a 0.18 percent increase in real GDP. Meaning that the level of and sign of initial GDP has a positive relationship with current GDP.
The results reveal a negative association between inflation and economic growth. A 1 percent increase in inflation leads to a 0.90 reduction in GDP. These results are supported by a number of empirical growth studies that have also found a negative association between inflation and economic growth in developing countries (e.g., [56, 57, 83, 84, 85, 86]).
The results show that government consumption is positively and significantly associated with the growth of real GDP at the 1 percent significance level. A 1 percent change in government consumption leads to a 0.06 percent increase in the growth of GDP. The positive relationship found between government consumption and economic growth is supported by similar studies in the empirical growth literature that have found a positive relationship between trade openness and economic growth (e.g., [17, 87]).
There is a positive and significant relationship between investment and economic growth at the 1 percent level of significance. A 1 percent increase in investment leads to a 0.19 percent increase in GDP. The results are consistent with existing empirical growth studies that have found a positive relationship between investment and economic growth (e.g., [10, 17, 88]).
The results show that foreign aid is negatively and significantly associated with the growth of real GDP, and the results are statistically significant at the 5 percent significance level. A 1 percent change in foreign aid leads to a 0.03 percent reduction in the growth of GDP. The negative relationship found between foreign aid and economic growth is supported by similar studies in the empirical growth literature (e.g., [10]).
The study results did not reveal a significant association between trade openness, population growth, human capital, and real GDP growth in the short run.
Sensitivity analysis was carried out to examine the significance of other variables or proxies for the variables used in regression II. This analysis was carried out bearing in mind theory, certain empirical studies and the nature of the Ugandan economy. Key variables/proxies were imports and exports as proxies for trade openness. Exports were found to be positively and significantly associated with GDP at the 1 percent level of significance, while imports were found to be non-significant.
From Table 3, Part A, regression II above, the ECT estimation results show that the estimated coefficient of the error correction term has the expected sign (negative) and is statistically significant. The ECT shows that a 1 percent deviation from the equilibrium path is corrected in the next period at a rate of −0.65 percent and is statistically significant at the 1 percent significance level. This confirms the presence of a long-run level equilibrium path between real GDP and the selected regressors (total school enrolment, primary; real exchange rate; population; government consumption; investment; inflation; foreign aid; imports; and exports). The regression results for the ARDL model reveal a good fit represented by an estimated
Part B, regression II of Table 3 presents the long-run coefficient estimates. The results reveal that the key macroeconomic determinants that are significantly associated with long-run GDP growth in Uganda are government consumption, investment, exports and the policy dummy.
The study reveals a positive relationship between government consumption and real GDP growth at the 1 percent significance level in the long run. A 1 percent increase in government consumption results in a 0.20 percent increase in the level of real GDP. These results are supported by Doppelhofer and Weeks [89] who find a positive relationship between government consumption and economic growth in the long run in developing countries.
The study reveals a positive relationship between investment and real GDP growth at the 1 percent significance level in the long run. A 1 percent increase in the level of investment results in a 0.22 percent increase in the level of real GDP. These results are supported by similar studies conducted in developing countries that have found a positive relationship between investment and economic growth in the long run (e.g., [10, 17, 54, 81, 82]).
There is a positive and significant relationship between GDP and exports in the long run at the 1 percent level of significance. A 1 percent increase in exports leads to a 0.12 percent increase in GDP growth (see [14, 16]).
There is also a negative and significant relationship between GDP and the policy dummy for SAPs in Uganda, as a 1 percent increase in implementation of the SAPs leads to a 0.07 percent reduction in real GDP growth.
The study results did not reveal a significant association between population growth, inflation human capital and foreign aid, imports and GDP growth in the long run.
The short-run results for the sensitivity/option analysis are shown in Part A, regression II of Table 3 above. The key macroeconomic determinants that are significantly associated with the growth of real GDP in the short run are initial GDP, inflation, government consumption (percent, GDP), investment, exports, and the policy dummy in both the current and the previous period.
The results show that a 1 percent increase in initial real GDP leads to a 0.28 percent increase in real GDP.
The results reveal a negative association between inflation and economic growth. A 1 percent increase in inflation leads to a 0.90 percent reduction in GDP. These results are supported by a number of empirical growth studies that have also found a negative association between inflation and economic growth in developing countries (e.g., [55, 56, 57, 83, 84, 85, 86]).
The results show that government consumption is positively and significantly associated with the growth of real GDP at the 1 percent significance level. A 1 percent change in government consumption leads to a 0.07 percent increase in the growth of GDP. The positive relationship found between government consumption and economic growth is supported by similar studies in the empirical growth literature that have found a positive relationship between trade openness and economic growth (e.g., [17]).
There is a positive and significant relationship between investment and economic growth at the 1 percent level of significance. A 1 percent increase in investment leads to a 0.15 percent increase in GDP. The results are consistent with the existing empirical growth studies that have found a positive relationship between investment and economic growth (e.g., [10, 17, 88]).
The results show that exports are positively and significantly associated with the growth of real GDP at the 5 percent significance level. A 1 percent change in exports leads to a 0.03 percent increase in GDP growth. The positive relationship found between exports and GDP growth is supported by similar studies in the empirical growth literature (e.g., [14, 90]).
There was a negative and significant relationship between the implementation of the structural adjustment programmes and GDP growth in the current period. A 1 percent increase in the implementation of the SAPs led to a 0.1 reduction in GDP.
The results indicate that in the short run, policy variables contributed to economic growth more than factor accumulation, while in the long run, a mixture of factor accumulation and policy variables was the major driver of economic growth.
The regressions were tested to ascertain their applicability and robustness. Robustness was confirmed by the Breusch-Godfrey serial correlation LM test, Jarque-Bera normality test, recursive stability tests, and Breusch-Pagan-Godfrey heteroscedasticity test. This means that the model has the desired econometric properties of time series data.
Recursive Tests were done using a visual examination of the graphs of the recursive parameter estimates. Additionally, a formal statistical test to test the null hypothesis of model stability was undertaken using the CUSUM test [91]. Figure 2 regression I and regression II illustrate the CUSUM and CUSUMSQ at the 5 percent significance level.
CUSUM and CUSUMSQ results for the estimated growth equation.
As illustrated in Figure 2, the CUSUM test reveals parameter stability, while the results of the CUSUMQ test reveal variance stability given that the residuals for both tests are within the 5 percent critical lines. According to these tests, our ARDL model is stable and has no serial correlation.
Serial correlation was undertaken to test whether the residual is correlated with its own lagged values using the Breusch-Godfrey LM test for serial correlation, and the results are presented in Table 4 below.
Breusch-Godfrey serial correlation LM test | Regression I | Regression II | ||
---|---|---|---|---|
F-statistic | 1.332638 | Prob. F(3,13) | 0.2739 | 0.0223 |
Obs*R-squared | 7.526409 | Prob. Chi-Square(3) | 0.1921 | 0.0004 |
The Breusch-Godfrey test for serial correlation in the residuals of the regression.
The Breusch-Godfrey serial correlation test statistic for the null hypothesis of no serial correlation (Table 4) for regression I has a probability value of 0.2739, which is greater than 5 percent. Thus, we fail to reject the null hypothesis, which indicates that there is no serial correlation in the residuals.
The Breusch-Pagan-Godfrey tests for heteroscedasticity statistic for the null hypothesis of no heteroscedasticity in regressions I and II have probability values of 0.6996 and 0.0612, respectively, which are greater than 5 percent. Thus, we fail to reject the null hypothesis, which indicates that there is no heteroscedasticity in the residuals (Table 5).
Heteroscedasticity test: Breusch-Pagan-Godfrey | Model I (probability) | Model II | ||
---|---|---|---|---|
F-statistic | 0.760385 | Prob. F(15,16) | 0.6996 | 0.0612 |
Obs*R-squared | 13.31781 | Prob.Chi-Square(15) | 0.5778 | 0.1320 |
Scaled Explained SS | 2.325347 | Prob.Chi-Square(15) | 0.9999 | 0.9945 |
Breusch-Pagan-Godfrey test for heteroscedasticity results.
The ARDL model assumes that the residuals are normally distributed. The Jarque-Bera statistic is assumed to have a
As indicated in Figure 3, in regression I, the probability value for the Jarque-Bera statistic is 0.49 with a probability value of 0.782, which is more than 5 percent; hence, the residuals are normally distributed. In regression II, the probability value for the Jarque-Bera statistic is 0.647 with a probability value of 0.724, which is more than 5 percent; hence, the residuals are normally distributed. This means that statistical tests for inference on regression coefficients are reliable, since these tests require that the dependent variable (and hence the residuals) follows a normal distribution.
Histogram normality test model I.
Specification errors can be errors in the specification of the functional form that the equation should take in describing the relationship between the variable. If the F test statistic is greater than the F critical value, we reject the null hypothesis that the true specification is greater than the F critical value, hence reject the null hypothesis that the true specification is linear (which implies that the true specification is non-linear). If we are unable to reject the null, then the results suggest that the true specification is linear and the equation passes the Ramsey Reset test (Table 6).
Ramsey RESET Test | |||
---|---|---|---|
Equation: UNTITLED | |||
Specification: LRGDP LRGDP(−1) LTRO LTRO(−1) LPOPN LINF LINF(−1) LHC LHC(−1) LHC(−2) LGGC LGGC(−1) LGFCF LAID C | |||
Omitted variables: squares of fitted values | |||
Value | df | Probability | |
t-statistic | 0.326505 | 17 | 0.7481 |
F-statistic | 0.106606 | (1, 17) | 0.7480 |
Ramsey rest test for the functional form test results.
The probability values from the Ramsey rest test for the T and F statistics are greater than 0.05 level of significance, meaning that the estimated model is free from specification errors.
Attaining high and sustainable economic growth is a major policy objective for any country especially among developing countries. In this paper, we examined the macroeconomic determinants of economic growth in Uganda using the factor accumulation framework for the period 1982–2015.
The autoregressive distributed lag (ARDL) approach to co-integration was used to estimate both the short- and long-run elasticities of the selected macroeconomic determinants. The ARDL bounds testing approach to co-integration in the benchmark regression indicated that the key determinants that are positively associated with growth in GDP in the short run are the initial level of real GDP growth, government consumption and investment, while foreign aid, inflation and a dummy for SAPs were negatively and significantly associated with real GDP growth. The results failed to show that trade openness, population growth and human capital accumulation were significantly associated with real GDP growth in the short run [95, 96, 97, 98].
The study revealed that in the long run, trade openness, population growth and government consumption and investment were positively and significantly associated with GDP growth, while the policy dummy on SAPs was negatively and significantly associated with GDP. In the long run, the study failed to show that inflation, human capital and foreign aid were significantly associated with GDP growth. It can be concluded that in the short run, policy variables contributed to economic growth more than factor accumulation (physical and human capital), while in the long run, a mixture of both factor accumulation and policy variables was the major driver of economic growth.
The study results have significant policy implications for Uganda. They show that investment and population have are significantly associated with economic growth both in the short and long run. Thus, it is recommended that the economic strategies to be adopted should include those that create incentives to attract investment—with an emphasis on the adoption of labour–intensive technologies, on quality–based human capital development. In the short run trade openness, government consumption, foreign aid and inflation are positively and significantly associated with economic growth meaning that the country should pursue policies that enhance trade, government effectiveness, aid effectiveness and economic management.
The study found that the key determinants that were positively associated with growth in GDP in the short run were the initial level of GDP growth, government consumption, investment and a dummy for SAPs, while foreign aid and inflation were negatively associated with GDP growth. The results failed to show that trade openness, population growth and human capital accumulation were significantly associated with GDP growth in the short run. In the long run, the study revealed that trade openness, population growth, government consumption and investment were positively associated with GDP, while the policy dummy on SAPs was negatively associated with GDP growth. In the long run, the study failed to show that inflation, human capital and foreign aid were significantly associated with growth in GDP.
These results have significant policy implications for Uganda, both in the short and long run. In the short run it is recommended that economic strategies that would spur accumulation of physical capital/Investment, increase government consumption, improve price stability be pursued while in the long run, strategies that improve trade openness, population growth, government consumption and investment should be pursued.
We would like to acknowledge Prof John Dumba Ssentamu and Associate Professor Eria Hisali, for their insurmountable technical contribution to this paper through their reviews and comments.
"Open access contributes to scientific excellence and integrity. It opens up research results to wider analysis. It allows research results to be reused for new discoveries. And it enables the multi-disciplinary research that is needed to solve global 21st century problems. Open access connects science with society. It allows the public to engage with research. To go behind the headlines. And look at the scientific evidence. And it enables policy makers to draw on innovative solutions to societal challenges".
\n\nCarlos Moedas, the European Commissioner for Research Science and Innovation at the STM Annual Frankfurt Conference, October 2016.
",metaTitle:"About Open Access",metaDescription:"Open access contributes to scientific excellence and integrity. It opens up research results to wider analysis. It allows research results to be reused for new discoveries. And it enables the multi-disciplinary research that is needed to solve global 21st century problems. Open access connects science with society. It allows the public to engage with research. To go behind the headlines. And look at the scientific evidence. And it enables policy makers to draw on innovative solutions to societal challenges.\n\nCarlos Moedas, the European Commissioner for Research Science and Innovation at the STM Annual Frankfurt Conference, October 2016.",metaKeywords:null,canonicalURL:"about-open-access",contentRaw:'[{"type":"htmlEditorComponent","content":"The Open Access publishing movement started in the early 2000s when academic leaders from around the world participated in the formation of the Budapest Initiative. They developed recommendations for an Open Access publishing process, “which has worked for the past decade to provide the public with unrestricted, free access to scholarly research—much of which is publicly funded. Making the research publicly available to everyone—free of charge and without most copyright and licensing restrictions—will accelerate scientific research efforts and allow authors to reach a larger number of readers” (reference: http://www.budapestopenaccessinitiative.org)
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The Open Access publishing movement started in the early 2000s when academic leaders from around the world participated in the formation of the Budapest Initiative. They developed recommendations for an Open Access publishing process, “which has worked for the past decade to provide the public with unrestricted, free access to scholarly research—much of which is publicly funded. Making the research publicly available to everyone—free of charge and without most copyright and licensing restrictions—will accelerate scientific research efforts and allow authors to reach a larger number of readers” (reference: http://www.budapestopenaccessinitiative.org)
\n\nIntechOpen’s co-founders, both scientists themselves, created the company while undertaking research in robotics at Vienna University. Their goal was to spread research freely “for scientists, by scientists’ to the rest of the world via the Open Access publishing model. The company soon became a signatory of the Budapest Initiative, which currently has more than 1000 supporting organizations worldwide, ranging from universities to funders.
\n\nAt IntechOpen today, we are still as committed to working with organizations and people who care about scientific discovery, to putting the academic needs of the scientific community first, and to providing an Open Access environment where scientists can maximize their contribution to scientific advancement. By opening up access to the world’s scientific research articles and book chapters, we aim to facilitate greater opportunity for collaboration, scientific discovery and progress. We subscribe wholeheartedly to the Open Access definition:
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\n\nPeer Review Policies
\n\nAll scientific works are Peer Reviewed prior to publishing. Read more
\n\nOA Publishing Fees
\n\nThe Open Access publishing model employed by IntechOpen eliminates subscription charges and pay-per-view fees, enabling readers to access research at no cost. In order to sustain operations and keep our publications freely accessible we levy an Open Access Publishing Fee for manuscripts, which helps us cover the costs of editorial work and the production of books. Read more
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Liposuction is a procedure to improve the body contour and not a surgery to reduce weight, although recently people who have failed in their plans to lose weight look at liposuction as a means to contour their body figure. Tumescent liposuction of large volumes requires a meticulous selection of each patient; their preoperative evaluation and perioperative management are essential to obtain the expected results. The various techniques of general anesthesia are the most recommended and should be monitored in the usual way, as well as monitoring the total doses of infiltrated local anesthetics to avoid systemic toxicity. The management of intravenous fluids is controversial, but the current trend is the restricted use of hydrosaline solutions. The most feared complications are deep vein thrombosis, pulmonary thromboembolism, fat embolism, lung edema, hypothermia, infections and even death. The adherence to the management guidelines and prophylaxis of venous thrombosis/thromboembolism is mandatory.",book:{id:"6221",slug:"anesthesia-topics-for-plastic-and-reconstructive-surgery",title:"Anesthesia Topics for Plastic and Reconstructive Surgery",fullTitle:"Anesthesia Topics for Plastic and Reconstructive Surgery"},signatures:"Sergio Granados-Tinajero, Carlos Buenrostro-Vásquez, Cecilia\nCárdenas-Maytorena and Marcela Contreras-López",authors:[{id:"273532",title:"Dr.",name:"Sergio Octavio",middleName:null,surname:"Granados Tinajero",slug:"sergio-octavio-granados-tinajero",fullName:"Sergio Octavio Granados Tinajero"}]},{id:"30178",title:"Chest Mobilization Techniques for Improving Ventilation and Gas Exchange in Chronic Lung Disease",slug:"chest-mobilization-techniques-for-improving-ventilation-and-gas-exchange-in-chronic-lung-disease",totalDownloads:31193,totalCrossrefCites:0,totalDimensionsCites:5,abstract:null,book:{id:"648",slug:"chronic-obstructive-pulmonary-disease-current-concepts-and-practice",title:"Chronic Obstructive Pulmonary Disease",fullTitle:"Chronic Obstructive Pulmonary Disease - Current Concepts and Practice"},signatures:"Donrawee Leelarungrayub",authors:[{id:"73709",title:"Associate Prof.",name:"Jirakrit",middleName:null,surname:"Leelarungrayub",slug:"jirakrit-leelarungrayub",fullName:"Jirakrit Leelarungrayub"}]},{id:"46082",title:"Fecal Incontinence",slug:"fecal-incontinence",totalDownloads:3717,totalCrossrefCites:0,totalDimensionsCites:0,abstract:null,book:{id:"3835",slug:"fecal-incontinence-causes-management-and-outcome",title:"Fecal Incontinence",fullTitle:"Fecal Incontinence - Causes, Management and Outcome"},signatures:"Arzu Ilce",authors:[{id:"30672",title:"Dr.",name:"Arzu",middleName:null,surname:"Ilce",slug:"arzu-ilce",fullName:"Arzu Ilce"}]}],onlineFirstChaptersFilter:{topicId:"16",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"82537",title:"Mortality Rate in Pakistan - among Low and Middle-Income Countries",slug:"mortality-rate-in-pakistan-among-low-and-middle-income-countries",totalDownloads:1,totalDimensionsCites:0,doi:"10.5772/intechopen.105770",abstract:"Age-specific and sex-specific cause of death determination is becoming very important task particularly for low- and middle-income countries (LMICs). Therefore, consistent openly accessible information with reproducibility may have significant role in regulating the major causes of mortality both in premature child and adults. The United Nations (UN) reported that 86% deaths (48 million deaths) out of 56 million globally deaths occurred in the LMICs in 2010. The major dilemma is that most of the deaths do not have a diagnosis of COD in such countries. Despite of the allocation of a large portion of resources to decrease the devastating impacts of chronic illnesses, their prevalence as well as the health and economic consequences remains staggeringly high. There are multiple levels of interventions that can help in bringing about significant and promising improvements in the healthcare system. Currently, Pakistan is facing double burden of malnutrition with record high prevalence rates of chronic diseases. Pakistan spends only a marginal of its GDP (1.2%) versus the recommended 5% by World Health Organization. On average, there are eight hospitals per district, with people load per hospital being 165512.452 and poor data management in the country, and we lack a consistent local registry on all-cause of mortality. This article was planned to compile the data related to major causes and disease specific mortality rates for Pakistan and link these factors to the social-economic determinants of health.",book:{id:"11005",title:"Mortality Rates in Middle and Low-Income Countries",coverURL:"https://cdn.intechopen.com/books/images_new/11005.jpg"},signatures:"Umar Bacha and Naveed Munir"},{id:"82355",title:"Vein of Marshall Ethanol Infusion in Setting of Atrial Fibrillation Ablation",slug:"vein-of-marshall-ethanol-infusion-in-setting-of-atrial-fibrillation-ablation",totalDownloads:0,totalDimensionsCites:null,doi:"10.5772/intechopen.105593",abstract:"Catheter ablation especially in persistent atrial fibrillation has limited success. Strategies beyond pulmonary veins isolation failed to demonstrate improvement of long-term rhythm maintenance. The vein of Marshall (VOM) is a promising therapeutic target as it fit perfectly with “Coumel’s triangle”: triggers in form of focal activities or stable reentries priming atrial fibrillation comes typically from tissue surrounding the VOM, it colocalize with mitral line especially in the epicardial part difficult to approach by endocardial ablations, it contains autonomic parasympathetic and sympathetic innervation implicated in arrhythmogenesis. Epicardial chemical ablation by ethanol delivery directly inside the vein of Marshall represents an attractive therapeutic approach eliminating arrhythmic triggers and autonomic modulators and, as it colocalize with the trajectory of the mitral isthmus, completing the integrity of that linear lesion. Based on advantages provided from VOM alcoholization, this technique has been progressively introduced in addiction to standard ablation strategies in atrial fibrillation treatment. This chapter aims to describe the electrophysiological characteristics of vein of Marshall, the technical aspects of ethanol delivery and the evidences from the literature supporting the emerging role of VOM alcoholization in atrial fibrillation treatment.",book:{id:"11655",title:"Atrial Fibrillation - Diagnosis and Management in the 21st Century",coverURL:"https://cdn.intechopen.com/books/images_new/11655.jpg"},signatures:"Andrea Rossi, Procolo Marchese and Marcello Piacenti"},{id:"82535",title:"Advanced, Imageless Navigation in Contemporary THA: Optimising Acetabular Component Placement",slug:"advanced-imageless-navigation-in-contemporary-tha-optimising-acetabular-component-placement",totalDownloads:1,totalDimensionsCites:0,doi:"10.5772/intechopen.105493",abstract:"Total hip arthroplasty (THA) stands as a reliable and effective way to manage end-stage hip disease secondary to a number of aetiologic conditions. While target ‘safe zones’ are widely quoted and endorsed, an increasingly robust body of evidence suggests that such idealised implantation goals have limited utility in patient-to-patient considerations and that even with a precise goal in mind, surgeons perform inconsistently in achieving these targets intra-operatively. Inter-patient variability, the concept of ‘functional’ safe zones and the largely under-appreciated impact of poor patient positioning (and progressive loss of position during the case) are all recognised and evidence-supported opponents of conventional ‘40/15’ approaches. In an environment whereby accountable cost utility, maximised surgical consistency (i.e., outlier minimisation), improved attainment of target position, and awareness of the radiation exposure burden of many pre-operative templating regimes are all paramount, there appears to be an increasing role for the application of imageless ‘mini’ intra-operative navigation systems for primary (and revision) THA procedures. This chapter reviews the evolution of THA navigation and discusses contemporary applications, defines the challenges associated with unanticipated pelvic movement, and explores potential future directions in the use of this exciting technology.",book:{id:"11873",title:"Arthroplasty - Advanced Techniques and Future Perspectives",coverURL:"https://cdn.intechopen.com/books/images_new/11873.jpg"},signatures:"Andrew P. Kurmis"},{id:"82232",title:"The Nutritional Challenges in Dysphagia: Not Only a Matter of Nutrients",slug:"the-nutritional-challenges-in-dysphagia-not-only-a-matter-of-nutrients",totalDownloads:3,totalDimensionsCites:0,doi:"10.5772/intechopen.105167",abstract:"Oropharyngeal dysphagia can significantly affect food ingestion. Texture-modified foods and thickened fluids are proposed to alleviate this difficulty. The nutritional density of adapted foods is often insufficient to maintain adequate nutritional intakes. The current scientific knowledge relies on a weak correlation between clinical assessment and meals consumed by patients as well as few clinical trials to support the efficacy of any treatment. The negative organoleptic perceptions associated with dysphagia diets further exacerbate undernutrition and malnutrition. Over the years, scientist in food science, nutritionists, psychologists and other health professionals have proposed parameters when formulating novel foods for the treatment of dysphagia. Beyond the nutritional composition of adapted foods for the treatment of dysphagia, this chapter will present multidimensional factors affecting food intake, sensory evaluations, rheological parameters as well as the available research to date with respect to optimizing nutritional treatment of dysphagia. To date, extrapolation to everyday food formulations remains a real challenge. To ensure success, thorough, individualized nutritional care plans need to be implemented and monitored regularly. An international knowledge transfer database must be considered to help document the innovations proposed in texture-modified foods and thickened fluids in order to benefit patients of all ages and origins.",book:{id:"11044",title:"Dysphagia - New Advances",coverURL:"https://cdn.intechopen.com/books/images_new/11044.jpg"},signatures:"Isabelle Germain"},{id:"82514",title:"Role of Leptin in Obesity Management: Current and Herbal Treatment",slug:"role-of-leptin-in-obesity-management-current-and-herbal-treatment",totalDownloads:2,totalDimensionsCites:0,doi:"10.5772/intechopen.105862",abstract:"Obesity is an excessive accumulation of fat in the body associated with numerous complications such as development of hypertension, type 2 diabetes (T2DM), dyslipidemia, sleep apnea, and respiratory disorders; and ultimately life-threatening cardiovascular disease (CVD), stroke, certain types of cancer and osteoarthritis. In 2016, more than 1.9 billion adults aged 18 years and older were overweight. Of these, over 650 million adults were obese, that is over 39% of men and 40% of women were overweight. Rapid rise in obesity cases in both developed and developing countries and people suffering from it needs rapid and complete cure form it without any side effects. Herbal medicine has been used for the treatment of disease for more than 2000 years, and it has proven efficacy. Many studies have confirmed that herbal medicines are effective in the treatment of obesity. Various plants from different families and several phytochemical constituents are responsible for the anti-obesity activity such as fenugreek cinnamon, cardamom, ginger, etc. Present work mainly cover herbal species having leptin-stimulating potential for weight management, importance of leptin, its mechanism of action, current and herbal treatment for effective weight management.",book:{id:"11022",title:"Weight Management - Challenges and Opportunities",coverURL:"https://cdn.intechopen.com/books/images_new/11022.jpg"},signatures:"Sunil T. Galatage, Sakshi N. Gurav, Mahadevi R. Moladi, Tejal R. Podjale, Nikita B. Tejam, Arehalli S. Manjappa, Popat S. Kumbhar, Supriya V. Nikade, Swapnil S. Chopade, Sujit A. Desai, Shweta N. Kalebere and Suresh G. Killedar"},{id:"81906",title:"New Use of the SSRI Fluvoxamine in the Treatment of COVID-19 Symptoms",slug:"new-use-of-the-ssri-fluvoxamine-in-the-treatment-of-covid-19-symptoms",totalDownloads:1,totalDimensionsCites:0,doi:"10.5772/intechopen.105023",abstract:"From the perspective of repurposing medication, recent evidence suggests that the use of selective serotonin reuptake inhibitor antidepressants (SSRIs) can help reduce the severity of symptoms and death associated with SARS-CoV-2 infection. To focus more, COVID-19 is a viral disease with potentially high risk of symptoms. There is presently no cure. However, there are specific treatments that may help manage the condition. Since the SSRI fluvoxamine has a unique mechanism of action in reducing cytokine production, researchers have started to relate the antiviral effects via modulation of sigma-1 receptors with the vision of treatment options for COVID-19 patients. The scope of this chapter is to examine different mechanisms of fluvoxamine in relation to immune response, including both the serotonin and the sigma-1 receptor-related mechanisms. Addressing the impact of fluvoxamine in minimizing possible complications during COVID-19 infection.",book:{id:"11592",title:"COVID-19 Pandemic, Mental Health and Neuroscience - New Scenarios for Understanding and Treatment",coverURL:"https://cdn.intechopen.com/books/images_new/11592.jpg"},signatures:"Jawza F. Alsabhan and Tahani K. 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The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"6",title:"Infectious Diseases",doi:"10.5772/intechopen.71852",issn:"2631-6188",scope:"This series will provide a comprehensive overview of recent research trends in various Infectious Diseases (as per the most recent Baltimore classification). Topics will include general overviews of infections, immunopathology, diagnosis, treatment, epidemiology, etiology, and current clinical recommendations for managing infectious diseases. Ongoing issues, recent advances, and future diagnostic approaches and therapeutic strategies will also be discussed. This book series will focus on various aspects and properties of infectious diseases whose deep understanding is essential for safeguarding the human race from losing resources and economies due to pathogens.",coverUrl:"https://cdn.intechopen.com/series/covers/6.jpg",latestPublicationDate:"June 25th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:13,editor:{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",biography:"Dr. Rodriguez-Morales is an expert in tropical and emerging diseases, particularly zoonotic and vector-borne diseases (especially arboviral diseases). He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"3",title:"Bacterial Infectious Diseases",coverUrl:"https://cdn.intechopen.com/series_topics/covers/3.jpg",isOpenForSubmission:!1,editor:null,editorTwo:null,editorThree:null},{id:"4",title:"Fungal Infectious Diseases",coverUrl:"https://cdn.intechopen.com/series_topics/covers/4.jpg",isOpenForSubmission:!0,editor:{id:"174134",title:"Dr.",name:"Yuping",middleName:null,surname:"Ran",slug:"yuping-ran",fullName:"Yuping Ran",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bS9d6QAC/Profile_Picture_1630330675373",biography:"Dr. Yuping Ran, Professor, Department of Dermatology, West China Hospital, Sichuan University, Chengdu, China. Completed the Course Medical Mycology, the Centraalbureau voor Schimmelcultures (CBS), Fungal Biodiversity Centre, Netherlands (2006). International Union of Microbiological Societies (IUMS) Fellow, and International Emerging Infectious Diseases (IEID) Fellow, Centers for Diseases Control and Prevention (CDC), Atlanta, USA. Diploma of Dermatological Scientist, Japanese Society for Investigative Dermatology. Ph.D. of Juntendo University, Japan. Bachelor’s and Master’s degree, Medicine, West China University of Medical Sciences. Chair of Sichuan Medical Association Dermatology Committee. General Secretary of The 19th Annual Meeting of Chinese Society of Dermatology and the Asia Pacific Society for Medical Mycology (2013). In charge of the Annual Medical Mycology Course over 20-years authorized by National Continue Medical Education Committee of China. Member of the board of directors of the Asia-Pacific Society for Medical Mycology (APSMM). Associate editor of Mycopathologia. Vice-chief of the editorial board of Chinses Journal of Mycology, China. Board Member and Chair of Mycology Group of Chinese Society of Dermatology.",institutionString:null,institution:{name:"Sichuan University",institutionURL:null,country:{name:"China"}}},editorTwo:null,editorThree:null},{id:"5",title:"Parasitic Infectious Diseases",coverUrl:"https://cdn.intechopen.com/series_topics/covers/5.jpg",isOpenForSubmission:!0,editor:{id:"67907",title:"Dr.",name:"Amidou",middleName:null,surname:"Samie",slug:"amidou-samie",fullName:"Amidou Samie",profilePictureURL:"https://mts.intechopen.com/storage/users/67907/images/system/67907.jpg",biography:"Dr. Amidou Samie is an Associate Professor of Microbiology at the University of Venda, in South Africa, where he graduated for his PhD in May 2008. He joined the Department of Microbiology the same year and has been giving lectures on topics covering parasitology, immunology, molecular biology and industrial microbiology. He is currently a rated researcher by the National Research Foundation of South Africa at category C2. He has published widely in the field of infectious diseases and has overseen several MSc’s and PhDs. His research activities mostly cover topics on infectious diseases from epidemiology to control. His particular interest lies in the study of intestinal protozoan parasites and opportunistic infections among HIV patients as well as the potential impact of childhood diarrhoea on growth and child development. He also conducts research on water-borne diseases and water quality and is involved in the evaluation of point-of-use water treatment technologies using silver and copper nanoparticles in collaboration with the University of Virginia, USA. He also studies the use of medicinal plants for the control of infectious diseases as well as antimicrobial drug resistance.",institutionString:null,institution:{name:"University of Venda",institutionURL:null,country:{name:"South Africa"}}},editorTwo:null,editorThree:null},{id:"6",title:"Viral Infectious Diseases",coverUrl:"https://cdn.intechopen.com/series_topics/covers/6.jpg",isOpenForSubmission:!0,editor:{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}},editorTwo:null,editorThree:null}]},overviewPageOFChapters:{paginationCount:10,paginationItems:[{id:"82380",title:"Evolution of Parasitism and Pathogenic Adaptations in Certain Medically Important Fungi",doi:"10.5772/intechopen.105206",signatures:"Gokul Shankar Sabesan, Ranjit Singh AJA, Ranjith Mehenderkar and Basanta Kumar Mohanty",slug:"evolution-of-parasitism-and-pathogenic-adaptations-in-certain-medically-important-fungi",totalDownloads:6,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Fungal Infectious Diseases - Annual Volume 2022",coverURL:"https://cdn.intechopen.com/books/images_new/11400.jpg",subseries:{id:"4",title:"Fungal Infectious Diseases"}}},{id:"82367",title:"Spatial Variation and Factors Associated with Unsuppressed HIV Viral Load among Women in an HIV Hyperendemic Area of KwaZulu-Natal, South Africa",doi:"10.5772/intechopen.105547",signatures:"Adenike O. 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