Results of splitting images into parts including all attributes.
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Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\\n\\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\\n"}]',published:!0,mainMedia:{caption:"Highly Cited",originalUrl:"/media/original/117"}},components:[{type:"htmlEditorComponent",content:'IntechOpen is proud to announce that 191 of our authors have made the Clarivate™ Highly Cited Researchers List for 2020, ranking them among the top 1% most-cited.
\n\nThroughout the years, the list has named a total of 261 IntechOpen authors as Highly Cited. Of those researchers, 69 have been featured on the list multiple times.
\n\n\n\nReleased this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\n\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\n'}],latestNews:[{slug:"intechopen-supports-asapbio-s-new-initiative-publish-your-reviews-20220729",title:"IntechOpen Supports ASAPbio’s New Initiative Publish Your Reviews"},{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"}]},book:{item:{type:"book",id:"10827",leadTitle:null,fullTitle:"Oral Health Care - An Important Issue of the Modern Society",title:"Oral Health Care",subtitle:"An Important Issue of the Modern Society",reviewType:"peer-reviewed",abstract:"Oral health care is an issue of modern society that is sometimes difficult to manage. Considered a key indicator of global health, well-being, and quality of life, oral health’s relationship with general health is of utmost importance. As such, maintenance of oral health should be a lifelong commitment as well as a daily priority. This book includes twenty chapters that focus on different aspects of oral health issues, including prevention, treatment, and management.",isbn:"978-1-80355-124-1",printIsbn:"978-1-80355-123-4",pdfIsbn:"978-1-80355-125-8",doi:null,price:139,priceEur:155,priceUsd:179,slug:"oral-health-care-an-important-issue-of-the-modern-society",numberOfPages:368,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"9a0ceb9ced4598aea3f3723f6dc4ea04",bookSignature:"Lavinia Cosmina Ardelean and Laura Cristina Rusu",publishedDate:"August 17th 2022",coverURL:"https://cdn.intechopen.com/books/images_new/10827.jpg",numberOfDownloads:2237,numberOfWosCitations:0,numberOfCrossrefCitations:1,numberOfCrossrefCitationsByBook:null,numberOfDimensionsCitations:1,numberOfDimensionsCitationsByBook:null,hasAltmetrics:0,numberOfTotalCitations:2,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"July 7th 2021",dateEndSecondStepPublish:"August 4th 2021",dateEndThirdStepPublish:"October 3rd 2021",dateEndFourthStepPublish:"December 22nd 2021",dateEndFifthStepPublish:"February 20th 2022",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"180569",title:"Dr.",name:"Lavinia",middleName:null,surname:"Ardelean",slug:"lavinia-ardelean",fullName:"Lavinia Ardelean",profilePictureURL:"https://mts.intechopen.com/storage/users/180569/images/system/180569.png",biography:"Professor Lavinia Cosmina Ardelean, DMD, Ph.D., is a professor and head of the Department of Technology of Materials and\nDevices in Dental Medicine, “Victor Babes” University of Medicine\nand Pharmacy, Timisoara, Romania. She has authored/co-authored 16 books, 10 book chapters, and 120 peer-reviewed papers.\nShe is an editorial board member of numerous journals and a\nmember of reviewer/topic boards of Materials, Prosthesis, Metals,\nand Polymers, and an academic editor for Scanning. She has guest-edited five special\nissues in different journals and is an active reviewer, with more than 200 reviews to\nher credit so far. Her research interest includes most areas of dentistry, with a focus\non dental materials/biomaterials, dental alloys, resins, ceramics/bioceramics, CAD/\nCAM milling, 3D printing/bioprinting in dentistry, laser welding, scanning, and oral\nhealth care.",institutionString:"Victor Babeș University of Medicine and Pharmacy Timișoara",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"8",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"Victor Babeș University of Medicine and Pharmacy Timișoara",institutionURL:null,country:{name:"Romania"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:{id:"174262",title:"Prof.",name:"Laura",middleName:"Cristina",surname:"Rusu",slug:"laura-rusu",fullName:"Laura Rusu",profilePictureURL:"https://mts.intechopen.com/storage/users/174262/images/system/174262.png",biography:'Professor Laura Cristina Rusu, DMD, Ph.D., is the mother of two lovely boys and a full-time professor and head of the Oral Pathology Department, Faculty of Dental Medicine, \\"Victor Babes\\" University of Medicine and Pharmacy, Timisoara, Romania. Her Ph.D. thesis was centered on allergens in dental materials. In 2017 she obtained a Dr. Habil and was confirmed as a Ph.D. coordinator in the field of dental medicine. She took part in 10 research projects, including FP7 COST Action MP 1005, and authored 140 peer-reviewed papers. She has published eight books and book chapters as an author and co-author. Her main scientific interests are oral pathology and oral diagnosis in dental medicine, with a focus on oral cancer.',institutionString:"Victor Babeș University of Medicine and Pharmacy Timișoara",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"5",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"Victor Babeș University of Medicine and Pharmacy Timișoara",institutionURL:null,country:{name:"Romania"}}},coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"996",title:"Dental Public Health",slug:"dental-public-health"}],chapters:[{id:"79754",title:"Evaluation of Trans-Resveratrol as a Treatment for Periodontitis",doi:"10.5772/intechopen.101477",slug:"evaluation-of-trans-resveratrol-as-a-treatment-for-periodontitis",totalDownloads:112,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:1,abstract:"Periodontitis is a globally prevalent inflammation-mediated disease that can result in varying degrees of destruction to the tissues supporting the teeth. The microbial pathogenic dysbiosis, oxidative stress, and deregulated inflammation, found in patients with periodontitis, make it a multifaceted condition that is difficult to fully resolve. Further to this, periodontitis has been associated with other systemic inflammatory conditions. Trans-resveratrol (3,5,4′-trihydroxy-trans-stilbene) is a plant-derived molecule present in many foods, which have been shown to exhibit antimicrobial, antioxidant, anti-inflammatory, and regenerative properties. However, trans-resveratrol has been reported to have physicochemical shortcomings, which make its clinical translation a challenge. This review outlines a critical analysis of identified samples from the scientific literature that was conducted to assess the potential of RES as a viable therapeutic for periodontitis. The potential for the improvement of the limiting pharmacological profile of trans-resveratrol via nanoformulation is also explored.",signatures:"Tracey Lynn Harney",downloadPdfUrl:"/chapter/pdf-download/79754",previewPdfUrl:"/chapter/pdf-preview/79754",authors:[{id:"427771",title:"Dr.",name:"Tracey Lynn",surname:"Harney",slug:"tracey-lynn-harney",fullName:"Tracey Lynn Harney"}],corrections:null},{id:"80441",title:"Periodontitis and Heart Disease: Current Perspectives on the Associative Relationships and Preventive Impact",doi:"10.5772/intechopen.102669",slug:"periodontitis-and-heart-disease-current-perspectives-on-the-associative-relationships-and-preventive",totalDownloads:66,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Due to the important advancement and the accumulation of new evidence on the periodontitis-cardiovascular disease (CVD) relationship as well as the major medical, economic and social burden caused by both diseases this chapter aims to review existing epidemiological and pathogenetic links related to this topic. Also, this chapter aims to highlight the impact of the periodontitis-CVD relationships on clinical practice and on the preventive approaches targeting to decrease the impact of periodontitis on CVD. Periodontitis is an infectious disease eliciting local and general inflammation, which leads to periodontal destruction and systemic involvement. Several pathways could explain the link between periodontitis and CVD such as bacteraemia, chronic persistent systemic inflammation and oxidative stress. The first step in the treatment of periodontitis addresses the elimination of microbial components, which lead to a decrease in local and systemic inflammation. Periodontal therapy seems to positively impact CVD. Specialists should inform patients with CVD on the negative impact of periodontitis on their systemic status and refer patients to the periodontist for an extensive examination as routine management of CVD. Some possible risks of periodontal therapy should be considered in patients undergoing antithrombotic medication.",signatures:"Alexandra Roman, Andrada Soancă, Bogdan Caloian, Alexandru Bucur, Gabriela Valentina Caracostea, Andreia Paraschiva Preda, Dora Maria Popescu, Iulia Cristina Micu, Petra Șurlin, Andreea Ciurea, Diana Oneț, Mircea Viorel Ciurea, Dragoș Alexandru Țermure and Marius Negucioiu",downloadPdfUrl:"/chapter/pdf-download/80441",previewPdfUrl:"/chapter/pdf-preview/80441",authors:[{id:"106751",title:"Dr.",name:"Gabriela",surname:"Caracostea",slug:"gabriela-caracostea",fullName:"Gabriela Caracostea"},{id:"171921",title:"Prof.",name:"Petra",surname:"Surlin",slug:"petra-surlin",fullName:"Petra Surlin"},{id:"334418",title:"Dr.",name:"Iulia Cristina",surname:"Micu",slug:"iulia-cristina-micu",fullName:"Iulia Cristina Micu"},{id:"334422",title:"Prof.",name:"Alexandra",surname:"Roman",slug:"alexandra-roman",fullName:"Alexandra Roman"},{id:"334425",title:"Dr.",name:"Andreea",surname:"Ciurea",slug:"andreea-ciurea",fullName:"Andreea Ciurea"},{id:"334432",title:"Dr.",name:"Marius",surname:"Negucioiu",slug:"marius-negucioiu",fullName:"Marius Negucioiu"},{id:"334434",title:"Dr.",name:"Dragos Alexandru",surname:"Termure",slug:"dragos-alexandru-termure",fullName:"Dragos Alexandru Termure"},{id:"334436",title:"Dr.",name:"Mircea Viorel",surname:"Ciurea",slug:"mircea-viorel-ciurea",fullName:"Mircea Viorel Ciurea"},{id:"342946",title:"Dr.",name:"Andrada",surname:"Soanca",slug:"andrada-soanca",fullName:"Andrada Soanca"},{id:"342951",title:"Prof.",name:"Alexandru",surname:"Bucur",slug:"alexandru-bucur",fullName:"Alexandru Bucur"},{id:"350840",title:"Dr.",name:"Andreia",surname:"Preda",slug:"andreia-preda",fullName:"Andreia Preda"},{id:"451937",title:"Dr.",name:"Bogdan",surname:"Caloian",slug:"bogdan-caloian",fullName:"Bogdan Caloian"},{id:"451939",title:"Dr.",name:"Dora Maria",surname:"Popescu",slug:"dora-maria-popescu",fullName:"Dora Maria Popescu"},{id:"451941",title:"Dr.",name:"Diana",surname:"Oneț",slug:"diana-onet",fullName:"Diana Oneț"}],corrections:null},{id:"79387",title:"Ulcerative Lesions of the Oral Cavity",doi:"10.5772/intechopen.101215",slug:"ulcerative-lesions-of-the-oral-cavity",totalDownloads:170,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Apart from dental and periodontal diseases, oral mucosal lesions are also frequently encountered by both general dentists and dental specialists in outpatient clinics. Although these soft tissue lesions may only reveal a localized issue, sometimes they may be the only sign of a more serious underlying systemic condition. Thus, oral ulcerations pose a unique diagnostic challenge for healthcare providers and should be cautiously handled when they last for more than two weeks, even after any possible traumatic etiologies are eliminated. There are many different classifications regarding oral ulcerations based on their etiologic or clinical features. In order to provide a logical and simple stepwise guidance to accurate diagnosis, this chapter will categorize and explain these lesions based on their clinical properties.",signatures:"Nelli Yildirimyan",downloadPdfUrl:"/chapter/pdf-download/79387",previewPdfUrl:"/chapter/pdf-preview/79387",authors:[{id:"429238",title:"Dr.",name:"Nelli",surname:"Yildirimyan",slug:"nelli-yildirimyan",fullName:"Nelli Yildirimyan"}],corrections:null},{id:"80020",title:"Alternative Denture Base Materials for Allergic Patients",doi:"10.5772/intechopen.101956",slug:"alternative-denture-base-materials-for-allergic-patients",totalDownloads:198,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Traditionally, a denture base is manufactured using a heat-cured acrylic resin. This type of resin was first used in dental labs in 1936, being a great step forward. Because of the many disadvantages as increased porosity, high water sorption, polymerization shrinkage, allergenic potential and citotoxicity due to the residual monomer, awkward flasking and packaging, and difficult processing, alternatives were continuously searched. Monomer-free and high-impact acrylics were developed, and gold plating of the denture base was experienced, in order to provide an alternative to allergic patients. Once polymers developed, new types of resins, such as polyamides (nylon), acetal, epoxy resins, styrene, polycarbonate, vinyl, urethane, polyether ether ketone (PEEK), became available on the dental market, accompanied by modern technologies, such as injection. CAD/CAM milled and 3D printed denture bases represent the present state of the art in this domain. Our chapter aims to present these alternative materials, which are safe to use in cases of allergic patients and guarantee a healthy oral environment and a high degree of comfort.",signatures:"Lavinia Cosmina Ardelean, Laura-Cristina Rusu and Codruta Victoria Tigmeanu",downloadPdfUrl:"/chapter/pdf-download/80020",previewPdfUrl:"/chapter/pdf-preview/80020",authors:[{id:"180569",title:"Dr.",name:"Lavinia",surname:"Ardelean",slug:"lavinia-ardelean",fullName:"Lavinia Ardelean"},{id:"174262",title:"Prof.",name:"Laura",surname:"Rusu",slug:"laura-rusu",fullName:"Laura Rusu"},{id:"427691",title:"Dr.",name:"Codruta Victoria",surname:"Tigmeanu",slug:"codruta-victoria-tigmeanu",fullName:"Codruta Victoria Tigmeanu"}],corrections:null},{id:"79515",title:"White Spot Lesions and Remineralization",doi:"10.5772/intechopen.101372",slug:"white-spot-lesions-and-remineralization",totalDownloads:83,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"As all practitioners are aware, the prevalence and incidence of dental caries keep increasing constantly and therefore early diagnosis and cessation of further progression would greatly help in maintaining the sound tooth structure. One of the earliest signs of dental caries is a white spot lesion, which is mostly missed, and only treated when the condition worsens. WSL are areas of demineralized enamel that occur due to a prolonged period of retained microbial biofilms most commonly associated in patients with poor oral hygiene and fixed orthodontic appliances. If caught early and intervened, WSLs can be reversed. Therefore, the diagnosis and treatment of WSL are of outmost importance, and this chapter will explain in detail various methods of diagnosing WSLs, its treatment protocol with the significance of remineralization of the same.",signatures:"Monisha Khatri, Shreya Kishore, S. Nagarathinam, Suvetha Siva and Vanita Barai",downloadPdfUrl:"/chapter/pdf-download/79515",previewPdfUrl:"/chapter/pdf-preview/79515",authors:[{id:"334397",title:"Dr.",name:"Vanita",surname:"Barai",slug:"vanita-barai",fullName:"Vanita Barai"},{id:"334400",title:"Dr.",name:"Suvetha",surname:"Siva",slug:"suvetha-siva",fullName:"Suvetha Siva"},{id:"428780",title:"Assistant Prof.",name:"monisha",surname:"Khatri",slug:"monisha-khatri",fullName:"monisha Khatri"},{id:"440926",title:"Dr.",name:"Shreya",surname:"Kishore",slug:"shreya-kishore",fullName:"Shreya Kishore"},{id:"440927",title:"Dr.",name:"Nagarathinam",surname:"S",slug:"nagarathinam-s",fullName:"Nagarathinam S"}],corrections:null},{id:"79298",title:"Oral Cancer around Dental Implants: Are the Clinical Manifestations and the Oncogenic Mechanisms Unique?",doi:"10.5772/intechopen.101156",slug:"oral-cancer-around-dental-implants-are-the-clinical-manifestations-and-the-oncogenic-mechanisms-uniq",totalDownloads:140,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Osseointegrated implants have been an optimal treatment option for dental rehabilitation of fully or partially edentulous patients. Although peri-implantitis remains as the most common local risk factor for dental implant failure, the development of oral cancer involving the soft tissue around the titanium may lead to early implants loss and impact the quality of life of the patient negatively. Oral squamous cell carcinoma (OSCC) is the most common malignancy among head and neck tumors. It has higher prevalence in men over 50 years old, and in tobacco and/or alcohol users. Unfortunately, oral cancer is often detected in advanced stages, when the treatment options are limited. Thus, OSCC typically has poor prognosis. Despite the recent advances in oral carcinogenesis understanding, the relationship between dental implants and the development of malignant lesions around them is not completely understood. It has been suggested that the titanium corrosion occurring at the top of dental implants causes the release of metal ions. These ions might lead to oral epithelial genetic damage and higher susceptibility of normal mucosa to malignant transformation. The aim of this chapter was to review the clinical characteristics, diagnosis, and the possible carcinogenic mechanisms involved in oral cancer around dental implants.",signatures:"Gabriela Lopes dos Santos, Kaique Preto Alberto, Silas Antonio Juvêncio de Freitas Filho, Kellen Cristine Tjioe and Denise Tostes Oliveira",downloadPdfUrl:"/chapter/pdf-download/79298",previewPdfUrl:"/chapter/pdf-preview/79298",authors:[{id:"171992",title:"Dr.",name:"Denise Tostes",surname:"Oliveira",slug:"denise-tostes-oliveira",fullName:"Denise Tostes Oliveira"},{id:"363434",title:"Dr.",name:"Kellen Cristine",surname:"Tjioe",slug:"kellen-cristine-tjioe",fullName:"Kellen Cristine Tjioe"},{id:"428583",title:"MSc.",name:"Gabriela Lopes",surname:"Santos",slug:"gabriela-lopes-santos",fullName:"Gabriela Lopes Santos"},{id:"428584",title:"Dr.",name:"Silas Juvêncio",surname:"Freitas-Filho",slug:"silas-juvencio-freitas-filho",fullName:"Silas Juvêncio Freitas-Filho"},{id:"428585",title:"BSc.",name:"Kaique",surname:"Preto",slug:"kaique-preto",fullName:"Kaique Preto"}],corrections:null},{id:"73626",title:"Variability of Saliva Viscosity - Potential Impact",doi:"10.5772/intechopen.93933",slug:"variability-of-saliva-viscosity-potential-impact",totalDownloads:261,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"As novel COVID-19 testing develops, saliva has become of increasing interest as an alternate biological sample for rapid testing. The appeal in saliva-based testing lies within the ease of which samples are collected, as well as patient comfort throughout the collection process. With this, it has become increasingly important to delineate the characteristics of saliva viscosity due to its effects on the movement and interactions of the substances and molecules found within it. The characteristics that affect saliva viscosity include the presence of aggregates, variations in temperature, and time elapsed between sample collection and testing. Understanding how physicochemical properties and temperature affect saliva’s viscosity are important in generating guidelines for proper sample handling in saliva testing to ensure consistent and reliable results. In this study, passive sampling of saliva was analyzed. This type of collection ensures a more uniform saliva composition, suggesting that variations in viscosity can be attributed solely to modifications in saliva handling post-collection. The data suggested that saliva viscosity is greatest immediately following collection of the saliva sample, increases with higher quantities of aggregates in saliva, and decreases tremendously when the sample has been frozen and thawed to room temperature. These findings suggest that to ensure accuracy and uniformity in quantitative saliva-based test results, protocols should favor the testing of a sample immediately following its collection. The implications of these results in optimizing saliva testing are far reaching. The value of saliva based testing extends far beyond COVID-19 or other disease testing. It is also gaining utility in understanding daily fluctuations in hydration state and in other wellness applications.",signatures:"Lara Eltze, Maren Eltze and Antonio Garcia",downloadPdfUrl:"/chapter/pdf-download/73626",previewPdfUrl:"/chapter/pdf-preview/73626",authors:[{id:"323573",title:"Distinguished Prof.",name:"Antonio",surname:"Garcia",slug:"antonio-garcia",fullName:"Antonio Garcia"},{id:"323574",title:"Ms.",name:"Lara",surname:"Eltze",slug:"lara-eltze",fullName:"Lara Eltze"},{id:"323585",title:"Ms.",name:"Maren",surname:"Eltze",slug:"maren-eltze",fullName:"Maren Eltze"}],corrections:null},{id:"79699",title:"Metabolomics Distinction of Cigarette Smokers from Non-Smokers Using Non-Stationary Benchtop Nuclear Magnetic Resonance (NMR) Analysis of Human Saliva",doi:"10.5772/intechopen.101414",slug:"metabolomics-distinction-of-cigarette-smokers-from-non-smokers-using-non-stationary-benchtop-nuclear",totalDownloads:56,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Implementations of high-field nuclear magnetic resonance (NMR) facilities into metabolomics studies are unfortunately restricted by their large dimensions, high costings, and specialist technical staff requirements. Therefore, here the application and practical advantages offered by low-field (60 MHz), compact NMR spectrometers for probing the metabolic profiles of human saliva was explored, as was their value in salivary metabolomics studies. Saliva samples were collected from cigarette smoking (n = 11) and non-smoking (n = 31) human participants. 1H NMR spectra were acquired on both low-field (60 MHz) and medium-field (400 MHz) spectrometers. Metabolomics analyses were employed to evaluate the consistencies of salivary metabolite levels determined, and their abilities to distinguish between smokers and non-smokers. Low-field 1H NMR analysis detected up to 15, albeit permitted the reliable quantification of 5, potentially key diagnostic biomolecules simultaneously (LLOQ values 250–400 μmol/L), although these were limited to those with the most prominent resonances. Such low-field profiles were also found to be suitable for salivary metabolomics investigations, which confirmed the successful discrimination between smoking and non-smoking participant sample donors. Differences observed between these groups were largely ascribable to upregulated salivary levels of methanol, and its metabolite formate, in the smoking group, but higher smoking-mediated concentrations of acetate, propionate and glycine may arise from a diminished salivary flow-rate in these participants. In conclusion, determination of salivary biomolecules using low-field, benchtop 1H NMR analysis techniques were found to be valuable for bioanalytical and metabolomics investigations. Future perspectives for the applications of this non-stationary NMR technique, for example for the on-site ‘point-of-care’ testing of saliva samples for diagnostic oral disease screening purposes at dental surgeries and community pharmacies, are considered.",signatures:"Benita C. Percival, Angela Wann, Sophie Taylor, Mark Edgar, Miles Gibson and Martin Grootveld",downloadPdfUrl:"/chapter/pdf-download/79699",previewPdfUrl:"/chapter/pdf-preview/79699",authors:[{id:"428637",title:"Prof.",name:"Martin",surname:"Grootveld",slug:"martin-grootveld",fullName:"Martin Grootveld"},{id:"441074",title:"Dr.",name:"Benita",surname:"Percival",slug:"benita-percival",fullName:"Benita Percival"},{id:"441077",title:"Mrs.",name:"Angela",surname:"Wann",slug:"angela-wann",fullName:"Angela Wann"},{id:"441078",title:"BSc.",name:"Sophie",surname:"Taylor",slug:"sophie-taylor",fullName:"Sophie Taylor"},{id:"441079",title:"Dr.",name:"Mark",surname:"Edgar",slug:"mark-edgar",fullName:"Mark Edgar"},{id:"441080",title:"BSc.",name:"Miles",surname:"Gibson",slug:"miles-gibson",fullName:"Miles Gibson"}],corrections:null},{id:"79903",title:"Molecular Docking of Phytochemicals against Streptococcus mutans Virulence Targets: A Proteomic Insight into Drug Planning",doi:"10.5772/intechopen.101506",slug:"molecular-docking-of-phytochemicals-against-em-streptococcus-mutans-em-virulence-targets-a-proteomic",totalDownloads:114,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Streptococcus mutans (S. mutans) is the most prevalent and most associated with dental caries. Here we aim to identify, through an in silico study, potential bioactive molecules against S. mutans. Twenty-four bioactive molecules with proven action against S. mutans were selected: 1-methoxyficifolinol; 5,7,2′,4′-tetrahydroxy-8-lavandulylflavanone (sophoraflavanone G); 6,8-diprenylgenistein; apigenin; artocarpesin; artocarpin; darbergioidin; dihydrobiochanin A; dihydrocajanin (5,2′,4′-trihydroxy-7-methoxyisoflavanone); erycristagallin; Erystagallin; ferreirin; fisetin; kaempferol; licoricidin; licorisoflavan A; licorisoflavan C; licorisoflavan E; luteolin (3′,4′,5,7-tetrahydroxyflavone); malvidin-3,5-diglucoside; myricetin; orientanol B; quercetin; and quercitrin. Moreover, we selected nine important target proteins for the virulence of this microorganism to perform as drug targets: antigen I/II (region V) (PDB: 1JMM); Antigen I/II (carbox-terminal region) (PDB: 3QE5); Spap (PDB: 3OPU); UA159sp signaling peptide (PDB: 2I2J); TCP3 signaling peptide (PDB: 2I2H); ATP-binding protein ComA (PDB: 3VX4); glucanosucrase (PDB: 3AIC); dextranase (PDB: 3VMO), and Hemolysin (PDB: 2RK5). Five molecules were revealed to be the best ligands for at least three target proteins, highlighting the following compounds: 11 (erystagallin), 10 (erycristagallin), 1 (methoxyficifonilol), 20 (malvidin-3,5-diglucoside), and 2 (sophoraflavanone G), which indicates a possible multi-target action of these compounds. Therefore, based on these findings, in vitro and in vivo tests should be performed to validate the effectiveness of these compounds in inhibiting S. mutans virulence factors. Furthermore, the promising results of these assays will allow the incorporation of these phytoconstituents in products for oral use for the control of tooth decay.",signatures:"Diego Romário da Silva, Tahyná Duda Deps, Otavio Akira Souza Sakaguchi, Edja Maria Melo de Brito Costa, Carlus Alberto Oliveira dos Santos, Joanilda Paolla Raimundo e Silva, Bruna Dantas da Silva, Frederico Favaro Ribeiro, Francisco Jaime Bezerra Mendonça-Júnior and Andréa Cristina Barbosa da Silva",downloadPdfUrl:"/chapter/pdf-download/79903",previewPdfUrl:"/chapter/pdf-preview/79903",authors:[{id:"115449",title:"Prof.",name:"Andréa",surname:"Cristina Barbosa da Silva",slug:"andrea-cristina-barbosa-da-silva",fullName:"Andréa Cristina Barbosa da Silva"},{id:"173419",title:"Dr.",name:"Diego",surname:"Romario-Silva",slug:"diego-romario-silva",fullName:"Diego Romario-Silva"},{id:"420028",title:"Dr.",name:"Edja",surname:"Maria Melo de Brito Costa",slug:"edja-maria-melo-de-brito-costa",fullName:"Edja Maria Melo de Brito Costa"},{id:"420035",title:"Mr.",name:"Otávio",surname:"Akira Souza Sakaguchi",slug:"otavio-akira-souza-sakaguchi",fullName:"Otávio Akira Souza Sakaguchi"},{id:"428144",title:"Dr.",name:"Francisco",surname:"Mendonça",slug:"francisco-mendonca",fullName:"Francisco Mendonça"},{id:"428145",title:"Ms.",name:"Joanylda",surname:"Raimundo",slug:"joanylda-raimundo",fullName:"Joanylda Raimundo"},{id:"428147",title:"MSc.",name:"Carlus",surname:"Santos",slug:"carlus-santos",fullName:"Carlus Santos"},{id:"428148",title:"Ms.",name:"Bruna",surname:"Dantas",slug:"bruna-dantas",fullName:"Bruna Dantas"},{id:"428149",title:"Dr.",name:"Frederico",surname:"Ribeiro",slug:"frederico-ribeiro",fullName:"Frederico Ribeiro"},{id:"442352",title:"Dr.",name:"Tahyna",surname:"Deps",slug:"tahyna-deps",fullName:"Tahyna Deps"}],corrections:null},{id:"79821",title:"Oral Health Knowledge, Attitudes, and Behavior in Young Adults",doi:"10.5772/intechopen.101704",slug:"oral-health-knowledge-attitudes-and-behavior-in-young-adults",totalDownloads:0,totalCrossrefCites:null,totalDimensionsCites:null,hasAltmetrics:null,abstract:"Knowledge about the importance of oral health and oral hygiene practices, attitudes, and behavior among young adults shows the association of insufficient or irregular oral hygiene with the occurrence of gingival/periodontal diseases, caries, and consequently systemic disease occurrence including cardiovascular disease, cancer, diabetes mellitus, infections of the respiratory tract, adverse pregnancy outcomes, and neurological disorders. Public health dentists should be trained for oral health needs assessments as well as for the evaluation of community-based oral health improvement strategies among different population groups.",signatures:"Ljiljana Kesic, Radmila Obradovic, Milica Petrovic, Marija Bojovic, Dragoslav Lazic, Branislava Stojkovic and Simona Stojanovic",downloadPdfUrl:"/chapter/pdf-download/79821",previewPdfUrl:"/chapter/pdf-preview/79821",authors:[{id:"184105",title:"Prof.",name:"Ljiljana",surname:"Kesic",slug:"ljiljana-kesic",fullName:"Ljiljana Kesic"},{id:"287243",title:"Dr.",name:"Milica",surname:"Petrovic",slug:"milica-petrovic",fullName:"Milica Petrovic"},{id:"429090",title:"Dr.",name:"Marija",surname:"Bojovic",slug:"marija-bojovic",fullName:"Marija Bojovic"},{id:"429091",title:"Prof.",name:"Radmila",surname:"Obradovic",slug:"radmila-obradovic",fullName:"Radmila Obradovic"},{id:"429092",title:"Dr.",name:"Branislava",surname:"Stojkovic",slug:"branislava-stojkovic",fullName:"Branislava Stojkovic"},{id:"429093",title:"Dr.",name:"Simona",surname:"Stojanovic",slug:"simona-stojanovic",fullName:"Simona Stojanovic"},{id:"441980",title:"Prof.",name:"Dragoslav",surname:"Lazic",slug:"dragoslav-lazic",fullName:"Dragoslav Lazic"}],corrections:null},{id:"80964",title:"Upper Airway Expansion in Disabled Children",doi:"10.5772/intechopen.102830",slug:"upper-airway-expansion-in-disabled-children",totalDownloads:44,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Breathing is essential for life in all of its stages. Cellular, mitochondrial respiration requires an adequate supply of oxygen, provided by the air we breathe, after airway conduction, treatment by the lungs, and transport to tissues. At different stages of life, pediatric dentists and orthodontists can intervene in the upper airway, expanding it, which helps with ventilation. The greater airway space, if used, contributes in different ways to the child’s development and the recovery of respiratory problems and should always be present as a weapon that physicians and the population should know. The value of the techniques becomes even more important when applied to children and young people with disabilities who can significantly improve their development and performance. Rapid Maxillary Expansion and Extraoral Traction Appliances are two important pediatric resources to treat these children. Clinical practice of the authors, is discussed, emphasizing the importance of early intervention and the need for multi and interdisciplinary collaboration in the follow-up of disabled people.",signatures:"David Andrade, Joana Andrade, Maria-João Palha, Cristina Areias, Paula Macedo, Ana Norton, Miguel Palha, Lurdes Morais, Dóris Rocha Ruiz and Sônia Groisman",downloadPdfUrl:"/chapter/pdf-download/80964",previewPdfUrl:"/chapter/pdf-preview/80964",authors:[{id:"340209",title:"Associate Prof.",name:"David",surname:"Andrade",slug:"david-andrade",fullName:"David Andrade"},{id:"343442",title:"Prof.",name:"Cristina",surname:"Areias",slug:"cristina-areias",fullName:"Cristina Areias"},{id:"429504",title:"Prof.",name:"Miguel",surname:"Palha",slug:"miguel-palha",fullName:"Miguel Palha"},{id:"429506",title:"Dr.",name:"Lurdes",surname:"Morais",slug:"lurdes-morais",fullName:"Lurdes Morais"},{id:"429507",title:"Dr.",name:"Maria-João",surname:"Palha",slug:"maria-joao-palha",fullName:"Maria-João Palha"},{id:"451424",title:"Dr.",name:"Joana",surname:"Andrade",slug:"joana-andrade",fullName:"Joana Andrade"},{id:"451426",title:"Prof.",name:"Paula",surname:"Macedo",slug:"paula-macedo",fullName:"Paula Macedo"},{id:"451427",title:"Prof.",name:"Ana",surname:"Norton",slug:"ana-norton",fullName:"Ana Norton"},{id:"451432",title:"Prof.",name:"Dóris",surname:"Ruiz",slug:"doris-ruiz",fullName:"Dóris Ruiz"},{id:"451433",title:"Prof.",name:"Sônia",surname:"Groisman",slug:"sonia-groisman",fullName:"Sônia Groisman"}],corrections:null},{id:"79297",title:"Oral Health and Prevention in Older Adults",doi:"10.5772/intechopen.101043",slug:"oral-health-and-prevention-in-older-adults",totalDownloads:113,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The most prevalent oral diseases such as tooth decay and chronic periodontitis, are the main responsible for tooth loss, this causes a disability in the chewing function, which alters the selection of food, the pleasure of eating, and the state of nutrition. Even the use of total prostheses to replace this loss is not always satisfactory. In the emotional sphere, poor oral health causes discomfort and a decrease in self-esteem. Unfortunately, this continues to occur in older people despite the great scientific and technological advances in dentistry today. Health promotion, which includes health education and prevention, must be present in the course of people’s lives. In the prevention of oral diseases, consider not only biological factors as the only causes, but also alleviate and modify the social determinants of the disease. All those involved in the care of the older adults must promote prevention as the most important tool in favor of oral health, and make older people enjoy life with quality. Oral health is an invaluable asset and reward at this stage of life.",signatures:"Irma Fabiola Díaz-García, Dinorah Munira Hernández-Santos, Julio Alberto Díaz-Ramos and Neyda Ma. Mendoza-Ruvalcaba",downloadPdfUrl:"/chapter/pdf-download/79297",previewPdfUrl:"/chapter/pdf-preview/79297",authors:[{id:"427797",title:"Dr.",name:"Irma Fabiola",surname:"Díaz-García",slug:"irma-fabiola-diaz-garcia",fullName:"Irma Fabiola Díaz-García"},{id:"428184",title:"M.Sc.",name:"Dinorah Munira",surname:"Hernández-Santos",slug:"dinorah-munira-hernandez-santos",fullName:"Dinorah Munira Hernández-Santos"},{id:"428241",title:"Prof.",name:"Julio Alberto",surname:"Díaz-Ramos",slug:"julio-alberto-diaz-ramos",fullName:"Julio Alberto Díaz-Ramos"},{id:"428242",title:"Dr.",name:"Neyda Ma.",surname:"Mendoza-Ruvalcaba",slug:"neyda-ma.-mendoza-ruvalcaba",fullName:"Neyda Ma. Mendoza-Ruvalcaba"}],corrections:null},{id:"79498",title:"Oral Aspects and Dental Management of Special Needs Patient",doi:"10.5772/intechopen.101067",slug:"oral-aspects-and-dental-management-of-special-needs-patient",totalDownloads:122,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Individuals with special needs are the most underserved regarding healthcare needs in almost all populations. Special needs patients with intellectual disability have muscle coordination disorder, impaired oral motor function, drooling, weak muscles that cause chewing and swallowing problems. Also, soft diet consumption makes this population more prone to dental disease. They have more caries, missing teeth, orthodontic and periodontal problems. Besides more difficulties obtaining professional dental care than other segments of the population. Though many countries developed community-based systems to improve oral health for people with special needs, providing good oral health mainly depends on the effort of the families. Therefore the education of the caregiver about oral hygiene provision is also critical for the special needs patient to enjoy a lifetime of oral health the same as other members of the society.",signatures:"Pinar Kiymet Karataban",downloadPdfUrl:"/chapter/pdf-download/79498",previewPdfUrl:"/chapter/pdf-preview/79498",authors:[{id:"272237",title:"Dr.",name:"Pinar",surname:"Karataban",slug:"pinar-karataban",fullName:"Pinar Karataban"}],corrections:null},{id:"78767",title:"Oral Health Problems of Thai People Reported by Khon Kaen University Staffs during 1984 to 2020",doi:"10.5772/intechopen.100355",slug:"oral-health-problems-of-thai-people-reported-by-khon-kaen-university-staffs-during-1984-to-2020",totalDownloads:78,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"To improve the efficiency of the dental care service system in Thailand. To synthesize content from Khon Kaen University (KKU) staffs and students’ research and presentations from 1984 to 2020 about oral health hygiene and related diseases. Sixteen publications and presentations by KKU staffs and their students about oral health problems and management were retrieved, reviewed and analyzed. Poor oral health of people in the northeast of Thailand is found in every age group: children, adults and the aging, both male and female. There are still many oral health problems of Thai people in the northeast. KKU Field Works, Projects and Research were able to help reduce these oral health problems. An appropriate preventive oral health program needs to be developed and implemented in Northeastern Thailand.",signatures:"Amornrat Ratanasiri, Thitima Nutravong, Supaporn Chatrchaiwiwatana, Arisara Poosari, Thawalrat Ratanasiri and Kanokporn Wongchalee",downloadPdfUrl:"/chapter/pdf-download/78767",previewPdfUrl:"/chapter/pdf-preview/78767",authors:[{id:"100039",title:"Dr.",name:"Supaporn",surname:"Chatrchaiwiwatana",slug:"supaporn-chatrchaiwiwatana",fullName:"Supaporn Chatrchaiwiwatana"},{id:"427946",title:"Associate Prof.",name:"Amornrat",surname:"Ratanasiri",slug:"amornrat-ratanasiri",fullName:"Amornrat Ratanasiri"},{id:"427948",title:"Dr.",name:"Thitima",surname:"Nutravong",slug:"thitima-nutravong",fullName:"Thitima Nutravong"},{id:"427949",title:"Dr.",name:"Arisara",surname:"Poosari",slug:"arisara-poosari",fullName:"Arisara Poosari"},{id:"429672",title:"Dr.",name:"Thawalrat",surname:"Ratanasiri",slug:"thawalrat-ratanasiri",fullName:"Thawalrat Ratanasiri"},{id:"429673",title:"Dr.",name:"Kanokporn",surname:"Wongcharee",slug:"kanokporn-wongcharee",fullName:"Kanokporn Wongcharee"}],corrections:null},{id:"79876",title:"Management and Prevention Strategies for Treating Dentine Hypersensitivity",doi:"10.5772/intechopen.101495",slug:"management-and-prevention-strategies-for-treating-dentine-hypersensitivity",totalDownloads:94,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The clinician faces numerous challenges when confronted with patients complaining of oro-facial pain, which can involve both dental and non-dental causes. Perhaps one of the most enigmatic clinical conditions that a clinician may encounter is that of dentine hypersensitivity (DH), dentine sensitivity (DS) or root sensitivity (RS), which is both problematic to identify and difficult to treat and may have a major effect on the patient’s quality of life (QoL). Ideally, the clinician needs to prevent or minimize these effects to reduce any unnecessary discomfort for the patient and this may be accomplished through preventive strategies, the provision of the required information about the procedures both pre- and post-treatments as well as reassuring the patient in the event of any subsequent discomfort. Furthermore, it is important for the clinician to be able to correctly diagnose the exact cause of the patient’s discomfort and have the confidence to successfully manage the problem. This chapter aims to cover the relevant aspects for both diagnosing and managing DH with an emphasis on adopting a preventive strategy that will attempt to minimize or eliminate the problem, thereby enabling the patient to have an improved quality of life.",signatures:"David G. Gillam",downloadPdfUrl:"/chapter/pdf-download/79876",previewPdfUrl:"/chapter/pdf-preview/79876",authors:[{id:"429394",title:"Dr.",name:"David",surname:"Gillam",slug:"david-gillam",fullName:"David Gillam"}],corrections:null},{id:"80295",title:"Preventive Methods and Treatments of White Spot Lesions in Orthodontics",doi:"10.5772/intechopen.102064",slug:"preventive-methods-and-treatments-of-white-spot-lesions-in-orthodontics",totalDownloads:89,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The aim of orthodontic treatment is to improve the esthetics of the teeth and face, to provide a beautiful smile, and an adequate and permanent chewing function. In individuals with insufficient oral hygiene, demineralization begins in the mouth with a very low pH value, and as a result, white spot lesions formed by decalcification of the enamel layer can be seen during orthodontic treatment. Since lesions are the first stage of caries formation, it is possible to stop caries development at this stage. Many methods, such as improving oral hygiene, regulating diets, fluoridated agents, laser, casein phosphopeptide, and microabrasion, are used in the treatment of white spot lesions. Preventive methods are of great importance in terms of preventing future tooth loss and reducing the treatment process. The purpose of this article is to manage white spot lesions in orthodontic treatment and to examine risk factors and preventive methods based on the latest evidence.",signatures:"Elif Nadide Akay",downloadPdfUrl:"/chapter/pdf-download/80295",previewPdfUrl:"/chapter/pdf-preview/80295",authors:[{id:"428210",title:"Ph.D.",name:"elif nadide",surname:"akaypolat",slug:"elif-nadide-akaypolat",fullName:"elif nadide akaypolat"}],corrections:null},{id:"79409",title:"The Dental Implant Maintenance",doi:"10.5772/intechopen.101187",slug:"the-dental-implant-maintenance",totalDownloads:126,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"As dental implant treatment has become a part of mainstream dental therapy, it is imperative to implement dental implant maintenance guidelines to achieve the long-term success of implant prostheses. Earlier, the success of a dental implant was mainly focused on the surgical phase to achieve good primary stability, with time, this belief has taken a major paradigm shift towards implementing and ensuring a periodic recall and following a maintenance phase for dental implants to achieve long-term success. As the dental team strives to attain and maintain the long-term success of implant prostheses, the patient should also recognize that their contribution towards the success of implant prostheses is also equally indispensable. This chapter highlights the importance of maintaining oral hygiene in implant rehabilitated patients and enumerates the implant maintenance protocol to be followed along with the different in-home and in-office procedures which can be implemented to achieve long-term success of the implant and peri-implant structures.",signatures:"Gayathri Krishnamoorthy, Aparna I. Narayana and Dhanasekar Balakrishnan",downloadPdfUrl:"/chapter/pdf-download/79409",previewPdfUrl:"/chapter/pdf-preview/79409",authors:[{id:"429035",title:"Prof.",name:"Dhanasekar",surname:"Balakrishnan",slug:"dhanasekar-balakrishnan",fullName:"Dhanasekar Balakrishnan"},{id:"429036",title:"Dr.",name:"Gayathri",surname:"Krishnamoorthy",slug:"gayathri-krishnamoorthy",fullName:"Gayathri Krishnamoorthy"},{id:"439634",title:"Prof.",name:"Aparna",surname:"Narayana",slug:"aparna-narayana",fullName:"Aparna Narayana"}],corrections:null},{id:"80839",title:"Herbs and Oral Health",doi:"10.5772/intechopen.103715",slug:"herbs-and-oral-health",totalDownloads:70,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Herbal medicine has long been used to prevent and control disease, and it can minimize the potential side effects of chemical products. However, side effects from herbs do exist. Most of the challenges with herbal medicine revolves around inadequate information about the effect of herbs in the oral cavity, the mechanism of action, and potential side effects. There are several herbs described in this chapter have anti-inflammatory, anti-bacterial, anti-viral, anti-fungal in oral micro-organisms. It includes aloe vera, ginger, clove, cinnamon, garlic, neem, miswak, turmeric, tulsi, green tea, chamomile, fenugreek, anise plant, peppermint, bloodroot, caraway, eucalyptus, phyllanthus emblica, black seed, myrrh, rosemary, sage, and thyme; some may act as an alternative management option to current treatments for oral conditions such as caries prevention, gingivitis, periodontitis, oral burn, ulcers and inflammation, after extraction, dry mouth, pain reduction, anesthesia, intracanal medications, ill-fitting dentures, peri-implant mucositis and peri-implantitis. It can be used in several forms such as mouthwashes, toothpastes, topical agents or local drug delivery devices. However, more research is needed to understand their mechanisms and potential side effects.",signatures:"Zuhair S. Natto",downloadPdfUrl:"/chapter/pdf-download/80839",previewPdfUrl:"/chapter/pdf-preview/80839",authors:[{id:"427600",title:"Associate Prof.",name:"Zuhair",surname:"Natto",slug:"zuhair-natto",fullName:"Zuhair Natto"}],corrections:null},{id:"79371",title:"The Contrasting Effects between Caffeine and Theobromine on Crystallization: How the Non-fluoride Dentifrice Was Developed",doi:"10.5772/intechopen.101116",slug:"the-contrasting-effects-between-caffeine-and-theobromine-on-crystallization-how-the-non-fluoride-den",totalDownloads:143,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:1,abstract:"Caffeine and theobromine are members of the xanthine family. Coffee and soft drinks contain caffeine, whereas, in cacao, theobromine is the main ingredient. The mineral contents of the tooth which sucked the caffeine-containing dam’s milk were decreased. To determine if caffeine would affect enamel, dams were fed with a caffeine and pups were killed and first and second molars were extracted. Enamel was exposed to the acid solution and dissolved minerals from the enamel were measured. Calcium, phosphorus and magnesium from the first molars of the caffeine group were significantly dissolved. To determine why minerals were released, enamel was separated. The crystallite size of the enamel from the caffeine group showed decreased. If the pups with the same dietary regimen, but given a cariogenic diet, the caffeine group should show a higher incidence of dental caries. The caffeine group revealed higher caries scores. An in vitro experiment to grow apatite crystals was conducted, adding the various members of the xanthine. Theobromine produced larger crystal sizes than caffeine. Theobromine was added to the maternal diet. Dissolution experiments revealed that these minerals were far less dissolved. Comparative studies of the various parameters between theobromine and fluoride were conducted. Theobromine was superior to fluoride in every aspect.",signatures:"Tetsuo Nakamoto, Alexander U. Falster and William B. Simmons Jr",downloadPdfUrl:"/chapter/pdf-download/79371",previewPdfUrl:"/chapter/pdf-preview/79371",authors:[{id:"427893",title:"Dr.",name:"Tetsuo",surname:"Nakamoto",slug:"tetsuo-nakamoto",fullName:"Tetsuo Nakamoto"},{id:"441359",title:"Dr.",name:"Alexander U",surname:"Falster",slug:"alexander-u-falster",fullName:"Alexander U Falster"},{id:"441360",title:"Dr.",name:"William B.",surname:"Simmons Jr",slug:"william-b.-simmons-jr",fullName:"William B. Simmons Jr"}],corrections:null},{id:"79319",title:"Empirical Study on Medical Information and Communication Technology System in Dentistry in Southeast Asia",doi:"10.5772/intechopen.101080",slug:"empirical-study-on-medical-information-and-communication-technology-system-in-dentistry-in-southeast",totalDownloads:160,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"In the field of dentistry, diagnoses based on data obtained using medical imaging modalities such as digital panoramic radiography and cone beam computed tomography (CBCT) have been widely recommended for advanced dental care. In Lao People’s Democratic Republic (Laos), there are place where advanced dental imaging devices are available in only one university dental hospital. The establishment of an information and communication technology (ICT) system has been expected as telemedicine system, for sharing medical imaging data among medical institutions in Laos. Recently, regional medical cooperation using telemedicine has been developed in Japan, and medical imaging data have been provided and shared among medical institutions, by using a mobile tablet terminal application. Therefore, we have carried out the empirical research on the telemedicine system with the university in Laos. The technologies and research results from our project will be presented in this chapter.",signatures:"Ichiro Nakajima, Ken-ichiro Ejima, Yoshinori Arai, Kunihito Matsumoto, Kazuya Honda, Hirofumi Aboshi, Marina Hamaguchi, Akao Lyvongsa, Bounnhong Sidaphone, Somphone Phanthavong, Chanthavisao Phanthanalay and Souksavanh Vongsa",downloadPdfUrl:"/chapter/pdf-download/79319",previewPdfUrl:"/chapter/pdf-preview/79319",authors:[{id:"330581",title:"Prof.",name:"Ichiro",surname:"Nakajima",slug:"ichiro-nakajima",fullName:"Ichiro Nakajima"},{id:"443783",title:null,name:"Ken-ichiro",surname:"Ejima",slug:"ken-ichiro-ejima",fullName:"Ken-ichiro Ejima"},{id:"443784",title:"Prof.",name:"Yoshinori",surname:"Arai",slug:"yoshinori-arai",fullName:"Yoshinori Arai"},{id:"443785",title:"Associate Prof.",name:"Kunihito",surname:"Matsumoto",slug:"kunihito-matsumoto",fullName:"Kunihito Matsumoto"},{id:"443786",title:"Prof.",name:"Kazuya",surname:"Honda",slug:"kazuya-honda",fullName:"Kazuya Honda"},{id:"443787",title:"Prof.",name:"Hirofumi",surname:"Aboshi",slug:"hirofumi-aboshi",fullName:"Hirofumi Aboshi"},{id:"443788",title:"Dr.",name:"Marina",surname:"Hamaguch",slug:"marina-hamaguch",fullName:"Marina Hamaguch"},{id:"443789",title:"Associate Prof.",name:"Akao",surname:"Lyvongsa",slug:"akao-lyvongsa",fullName:"Akao Lyvongsa"},{id:"443790",title:null,name:"Bounnhong",surname:"Sidaphone",slug:"bounnhong-sidaphone",fullName:"Bounnhong Sidaphone"},{id:"443791",title:null,name:"Somphone",surname:"Phanthavong",slug:"somphone-phanthavong",fullName:"Somphone Phanthavong"},{id:"443792",title:null,name:"Chanthavisao",surname:"Phanthanalay",slug:"chanthavisao-phanthanalay",fullName:"Chanthavisao Phanthanalay"},{id:"443793",title:null,name:"Souksavanh",surname:"Vongsa",slug:"souksavanh-vongsa",fullName:"Souksavanh Vongsa"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:{id:"1",series:{id:"3",title:"Dentistry",issn:"2631-6218",editor:{id:"419588",title:"Ph.D.",name:"Sergio Alexandre",middleName:null,surname:"Gehrke",slug:"sergio-alexandre-gehrke",fullName:"Sergio Alexandre Gehrke",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038WgMKQA0/Profile_Picture_2022-06-02T11:44:20.jpg",biography:"Dr. Sergio Alexandre Gehrke is a doctorate holder in two fields. The first is a Ph.D. in Cellular and Molecular Biology from the Pontificia Catholic University, Porto Alegre, Brazil, in 2010 and the other is an International Ph.D. in Bioengineering from the Universidad Miguel Hernandez, Elche/Alicante, Spain, obtained in 2020. In 2018, he completed a postdoctoral fellowship in Materials Engineering in the NUCLEMAT of the Pontificia Catholic University, Porto Alegre, Brazil. He is currently the Director of the Postgraduate Program in Implantology of the Bioface/UCAM/PgO (Montevideo, Uruguay), Director of the Cathedra of Biotechnology of the Catholic University of Murcia (Murcia, Spain), an Extraordinary Full Professor of the Catholic University of Murcia (Murcia, Spain) as well as the Director of the private center of research Biotecnos – Technology and Science (Montevideo, Uruguay). Applied biomaterials, cellular and molecular biology, and dental implants are among his research interests. He has published several original papers in renowned journals. In addition, he is also a Collaborating Professor in several Postgraduate programs at different universities all over the world.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"Universidad Católica San Antonio de Murcia",institutionURL:null,country:{name:"Spain"}}}}},tags:null},relatedBooks:[{type:"book",id:"4540",title:"Emerging Trends in Oral Health Sciences and Dentistry",subtitle:null,isOpenForSubmission:!1,hash:"ea749600b092375e2437f3c639c207af",slug:"emerging-trends-in-oral-health-sciences-and-dentistry",bookSignature:"Mandeep Singh Virdi",coverURL:"https://cdn.intechopen.com/books/images_new/4540.jpg",editedByType:"Edited by",editors:[{id:"89556",title:"Prof.",name:"Mandeep",surname:"Virdi",slug:"mandeep-virdi",fullName:"Mandeep Virdi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1442",title:"Oral Health Care",subtitle:"Pediatric, Research, Epidemiology and Clinical Practices",isOpenForSubmission:!1,hash:"fc9cd3e64b2f0e750c0fac74d6983746",slug:"oral-health-care-pediatric-research-epidemiology-and-clinical-practices",bookSignature:"Mandeep Singh Virdi",coverURL:"https://cdn.intechopen.com/books/images_new/1442.jpg",editedByType:"Edited by",editors:[{id:"89556",title:"Prof.",name:"Mandeep",surname:"Virdi",slug:"mandeep-virdi",fullName:"Mandeep Virdi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2116",title:"Oral Health Care",subtitle:"Prosthodontics, Periodontology, Biology, Research and Systemic Conditions",isOpenForSubmission:!1,hash:"a0d5f8110fc46ac49a935b2e5f0992ce",slug:"oral-health-care-prosthodontics-periodontology-biology-research-and-systemic-conditions",bookSignature:"Mandeep Singh Virdi",coverURL:"https://cdn.intechopen.com/books/images_new/2116.jpg",editedByType:"Edited by",editors:[{id:"89556",title:"Prof.",name:"Mandeep",surname:"Virdi",slug:"mandeep-virdi",fullName:"Mandeep Virdi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5908",title:"Insights into Various Aspects of Oral Health",subtitle:null,isOpenForSubmission:!1,hash:"1dbc12a9a3a85664682fd8f81033996f",slug:"insights-into-various-aspects-of-oral-health",bookSignature:"Jane Francis Manakil",coverURL:"https://cdn.intechopen.com/books/images_new/5908.jpg",editedByType:"Edited by",editors:[{id:"68285",title:"Dr.",name:"Jane",surname:"Manakil",slug:"jane-manakil",fullName:"Jane Manakil"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. 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They have grown in around 50 different countries. They exhibit great diversity in production which is reflected in different species, differences in sowing and harvesting time, duration of the growing season, cultivars, traits such as quality, insect pests, and diseases that attack them. Brassica plants possess a myrosinase-glucosinolate defense system that is unique to crucifers. It acts as a defense against several insect pests and diseases. Among the different Brassica species, Brassica napus, B. Rapa, and B. Juncea are widely grown for oilseed production while B. Oleracea var. Italica, capitata, botrytis and Gemmifera, and B. Rapa var. Chinensis are grown as vegetables. B. Carinata has been grown in Ethiopia. Over the years, numerous publications on various aspects of Brassica with useful information have been published. The present book will compile all the data comprehensively. It will be of immense use to Brassica researchers, teachers, and students.
",isbn:"978-1-83962-502-2",printIsbn:"978-1-83962-501-5",pdfIsbn:"978-1-83962-635-7",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!1,isSalesforceBook:!1,isNomenclature:!1,hash:"79b540fc5f61052fefeddda2b07fcde9",bookSignature:"Dr. Sarwan Kumar",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11626.jpg",keywords:"Herbivore, Defense, Antixenosis, Antibiosis, Phytophagous, Herbivore, Rapeseed, Mustard, Myrosinase, Glucosinolate, Defense, Adaptation",numberOfDownloads:5,numberOfWosCitations:0,numberOfCrossrefCitations:0,numberOfDimensionsCitations:0,numberOfTotalCitations:0,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"April 13th 2022",dateEndSecondStepPublish:"May 11th 2022",dateEndThirdStepPublish:"July 10th 2022",dateEndFourthStepPublish:"September 28th 2022",dateEndFifthStepPublish:"November 27th 2022",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"3 months",secondStepPassed:!0,areRegistrationsClosed:!0,currentStepOfPublishingProcess:4,editedByType:null,kuFlag:!1,biosketch:"Dr. Kumar has more than 15 years of work experience on host plant resistance to insect pests with particular reference to Brassica crops. 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We focus our analysis to different activities that use social richness data, analyzing societies to improve diverse situational activities based on a decision support systems under uncertaainty. To this end, we performed surveys to gathering information about salient aspects of modernization and combined them using social data mining techniques to profile a number of behavioural patterns and choices that describe social networking behaviours in these societies.
We will define the terms “Data Mining” and “Decision Support System” as well as their contrast and roles in modern societies. Then we will describe innovative models that captures salient variables of modernization, and how these variables give raise to intervening aspects that end up shaping behavioural patterns in social aspects. We will describe the data mining methodologies we used to extract these variables in each one of these diverse application domains including the analysis of diverse surveys conducted in diverse societies, and provide a comparative analysis of the results in light of the proposed innovative social model.
On the rest proposed chapter, we will describe how our model can be extended to provide a means for identifying potential social public politics. More particularly, we make allusion to behavioural pattern recognition mechanisms that would identify the importance of use techniques from Data Mining. We will close with concluding remarks and extended discussions of our approach and will provide general guidelines for future work in the area of application of Data Mining in diverse application domains, including further analysis on how those public politics organize and operate in social rings, and how they use technology to that end. While our main focus will be on pure social networks such as Facebook. Our literature review will include cases of implementation of correct public politics, and some issues, challenges, opportunities, and trends about this diverses social problems.
The proposal of this chapter is to explain the importance of use Social Data Mining in a wide variety of activities in our daily life, many of these activities, which are online and involve many social networkings using in many ways using Media Richness. Social Data Mining techniques will be useful for answering diverse queries after gathering general information about this given topic. This kind of behaviors will be characterized by take a real implementation of a correct solution, each one of these taking diverse models or multi agents systems for adequate this behavior to obtain information to take decisions that try to improve aspects very important of their lifes organized in different application and fields of knowledge.
First, in section 1 of this Social Data Mining techniques will be useful for answering diverse questions after gathering general information about the given topic. This type of behaviors will be characterized by a real application of a correct solution, each one of these taking diverse models or multi agents systems. This is for adequate this behavior to have information and make decisions that try to improve aspects very important of their lifes organized in different application and fields of knowledge.
First, in section 1 of this chapter explain the concept of Social Data Mining and as this behavior affect in different way to people in differnet aspects in societies´ people –Viral Marketing to determine boughts on inmobilarie sector–. In other sections we explain the way to generate a correct analysis In correspondent sections we explain the way to make a correct analysis of diferent activities of daily life as in Electrical Industry (section 2), Classification of Images and its analysis which explain the effects in their analysis including Medical advances (section 3), a comparative analysis using people profile according to describe a possible social benefits in diverse applications domains (section 4). In section 5 we explain the results obtained in e-commerce data mining and emergent kind of techniques which resolve and propose specific kind of marketing according at life style of consumers, and in the section 6 are try to describe the use of Data Mining to Mobile Ad Hoc Networks Security which will be used to determine the possible changes on our modern society. In section 7 we described another specfic applications domains as: organizational models, organizational climate, zoo applications to classify more vulnerable species or identify the adequate kind of avatars on a roll multigame players and finally our conclusions about the future of Data Mining in diverses uses to different activities of our daily life.
The use of traditional media like radio, television and newspaper, has been replaced by new digital media like social networks Facebook and Twitter. According to (Salaverría, 2009) the increase of broadband users, both on mobile devices, home and workplace, has raised the replacement of traditional media by digital media. Likewise, mentions that these new tools allow the user to interact with the issuer, thanks to several factors that facilitate interaction such as, frequency of updates, including multimedia such as videos and photographs, among others.
On the other hand, (Orihuela, 2002) mentions that existing Internet interactivity has been subverting the paradigms within communication processes in mass media. As (Salaverría, 2009), mentions the ability of interactivity, customization and upgrade, as central in replacing traditional media to digital (Figure 1).
Interaction between users of social networks.
In their study, (Orihuela, 2002), concludes that the public announcement raised in the new digital media is sufficient justification to redefine the requirements in the media, the procedures and content of information, all within trends changing as a result of network usage.
Due to the above, the social networks like Facebook, are an important tool in the marketing strategy of companies. Its low cost (sometimes zero) helps not only in communicating the customer value, but also improves the customer-consumer relationships. According to (Orihuela, 2002), social networks like Facebook sometimes take characteristics of traditional media, however, incorporate a higher level of interaction.
After analyzing the above, we can say that the use of social networks helps greatly reducing advertising costs and implementation of new marketing strategies. But even if there are different tools to monitor and observe the behavior of users, there is little research evidence that reveals different patterns of consumption, transmission of messages or lack of them, and observes the behavior of these consumers on trademarks and their experiences with them within the social networks like Facebook.
According to (Salaverría, 2009) the online advertising industry grew by 800 percent from 2004 to 2009 demonstrating a steady development in which social networks and contextual advertising play an important role in the marketing or advertising on social networks, without But there is no scientific evidence on the behavior of users in such networks and the dissemination of messages received and sent within these networks and what encourages you to do or not.
(Sandoval et al., 2010) mentions that social networks have changed the human relations approach and have potentiating its most important feature: Easy to find and develop relationships with other members with similar interests. Similarly mention that social networking services have proliferated targeting people in specific regions or some similar interests as, ethnic, religious, sexual and political (Figure 5). Thus, the fact of having a community segment showing a potential interest in a particular company or product, is useful when performing a specific marketing strategy. In addition to marketing strategies, companies can use such networks in the recruitment, internal communication and interaction with consumers.
Nested groups of similar interests.
Having analyzed the use of social networks in business, the importance of the restaurant industry in Mexico and specifically the problem of insecurity in Juarez, perform the following research questions:
What specific objectives seek restaurant sector companies to use social networks?
What digital social network use most frequently?
What percentage of these companies has replaced the traditional media advertising advertising on social networks?
What marketing strategies used in online social networks?
What correlation is there between; use of social networks and increased sales?
When beginning their presence within social networks?
How many users is made up your network?
How often publish information within social networks?
What correlation exists between the periodicity of the publications and the time spent in the network, with the number of users in the network?
The conclusive results of this research were obtained through an exploratory study of the use of social networks in companies in the restaurant industry in Juarez and factorial designs were performed to find some correlations between different variables.
First we made a query of the restaurant industry to recognize his presence in Mexico and in the locality. This was done through the National Chamber of the Restaurant Industry and Seasoned Foods (CANIRAC) and National Chamber of Commerce (CANACO) found in the locality.
From the list of registered companies in the industry by these cameras restaurateur, was searched to select those that were present within the digital social networks, regardless of upgrade or number of users connected to their groups. Were interviewed and application of survey of 20 companies with the largest number of users within your network, to meet their business openly in online social networks, specifically Facebook. Took place through a careful study of social networks to find that participation in that network have to know the frequency and topics of their publications, as well as general information of relevance to publish within their Facebook page. He knew the date they started their activities in the network. Once the information was held after his capture to be analyzed in statistical software to find relevant values.
Competitive learning is an efficient tool for Self Organizing Maps, widely applied in variety of signal processing problems such as classification, data compression, in anothers. With the huge volumes of data being generated from the different systems everyday, what makes a system intelligent is its ability to analyze the data for efficient decision-making based on known or new cluster discovery.
The phase resolved analysis investigates the PD pattern in relation to the variable frequency AC cycle (Cheng et al., 2008). The voltage phase angle is divided into small equal windows. The analysis aims to calculate the integrated parameters for each phase window and to plot them against the phase position ().
Example of damage in polymeric power cable from the PD in a cavity to breakdown.
(
The Self Organizing Map developed by Kohonen, is the most popular neural network models (Kohonen, T., 2006 & Rubio-Sánchez, M., 2004). The SOM is a neural network model that implements a characteristics non-linear mapping from the high-dimensional space of input signal onto a typically 2-dimensional grid of neurons. The SOM is a two-layer neural network that consists of an input layer in a line and an output layer constructed of neurons in a two-dimensional grid.
The component interaction between SOM.
PD measurements for power cables are generated and recorded through laboratory tests. Corona was produced with a point to hemisphere configuration: needle at high voltage and hemispherical cup at ground. Surface discharge XLPE cable with no stress relief termination applied to the two ends. High voltage was applied to the cable inner conductor and the cable sheath was grounded, this produces discharges along the outer insulation surface at the cable ends. Internal discharge was used a power cable with a fault due to electrical treeing. Were considered the pattern characteristic of univariate phase-resolved distributions as inputs, the magnitude of PD is the most important input as it shows the level of danger, for this reason the input in the SOM the raw data is the peak discharge magnitude for each phase window plotted against (qm − ). Figure 2 shows the conceptual diagram training. In the cases analyzed, the original dataset is 1 million of items, was used a neurons array of 1010 cells to extract features. As it is well known, in fact, a too small number of neurons per class could be not sufficient to represent the variability of the samples to be classified, while a too large number in general makes the net too much specialized on the samples belonging to the training set and consequently reduces its generalization capability. Moreover a too large number of neuron per class implies a long training time and a possible underutilization of some of the neural units. PD patterns recognition and classification require an understanding of the traits commonly associated with the different source and relationship between observed PD activity and responsible defect sources. This paper shows the performance of SOM using different competitive learning algorithms to classify measured PD activities into underlying insulation defects or source that generate PD’s, its showed that WTA is the better algorithm with less error and training time, but its overall performance are not always satisfactory, being alternative in accord at the performance FSCL or RPCL algorithms.
This research work’s approach is related to artificial vision due to extraction from information contained in images (human faces) by using methods to obtain RGB coloration and statistic values. Extraction takes place by performing several tests of image splitting into different sizes, later classifying sets of instances with data mining techniques, and analyzing classification results to determine which of the algorithms is the best for this particular case.
Knowledge database contains 100 images built from 20 people and 5 pictures each. Mean and standard deviation were employed as statistic values, which are also used as attributes of the instances classified by Naïve Bayes and WEKA J48. It is important to mention that no pixel is disregarded to obtain instances, both of the pixel groups the ones inside face and outside of it are considered. Impact of splitting images into parts.
Table 1 shows that splitting images into both 16 and 64 obtain the same amount of correctly classified instances except with NaiveBayes classifier under cross validation where splitting into 16 obtains 3% better of correctly classified instances, partial conclusion from this table is splitting images into both 16 and 64 is better than splitting them into 4 and no splitting them.
Table 2 shows both Naïve Bayes and J48 under use training test option obtain 100 % of correctly classified instances from splitting images into 4 parts which reveals splitting images helps for classification process.
1 | 4 | 16 | 64 | ||
NaiveBayes | use training set | 94% | 100% | 100% | 100% |
J48 | use training set | 97% | 100% | 100% | 100% |
NaiveBayes | cross validation folds 10 | 85% | 90% | 97% | 94% |
J48 | cross validation folds 10 | 71% | 86% | 85% | 85% |
NaiveBayes | percentage split 66% | 76.4706% | 70.5882% | 88.2353% | 88.2353% |
J48 | percentage split 66% | 64.7059% | 55.8824% | 64.7059% | 64.7059% |
Results of splitting images into parts including all attributes.
1 | 4 | 16 | 64 | ||
NaiveBayes | use training set | 90% | 100% | 100% | 100% |
J48 | use training set | 92% | 100% | 100% | 100% |
NaiveBayes | cross validation folds 10 | 72% | 93% | 97% | 96% |
J48 | cross validation folds 10 | 69% | 83% | 84% | 89% |
NaiveBayes | percentage split 66% | 58.8235% | 88.2353% | 94.1176% | 94.1176% |
J48 | percentage split 66% | 61.7647% | 70.5882% | 73.5294% | 76.4706% |
Results of splitting images into parts including best 30% attributes.
Table 3 shows that for any test option, both classifiers obtain greater amount of correctly classified instances considering all of the attributes which are 6.
Table 4 shows that both classifiers obtain 100% of correctly classified instances under use training set test option. Under cross validation Naïve Bayes classifies 3% better selecting 8 attributes and J48 classifies 3% considering all of the attributes. Finally under percentage split both classifiers perform better selecting 8 attributes.
Classifier | Test options | ||
NaiveBayes | use training set | 94% | 90% |
J48 | use training set | 97% | 92% |
NaiveBayes | cross validation folds 10 | 85% | 72% |
J48 | cross validation folds 10 | 71% | 69% |
NaiveBayes | percentage split 66% | 76.4706% | 58.8235% |
J48 | percentage split 66% | 64.7059% | 61.7647% |
Results of attribute selection without splitting images.
Classifier | Test options | ||
NaiveBayes | use training set | 100% | 100% |
J48 | use training set | 100% | 100% |
NaiveBayes | cross validation folds 10 | 90% | 93% |
J48 | cross validation folds 10 | 86% | 83% |
NaiveBayes | percentage split 66% | 70.5882% | 88.2353% |
J48 | percentage split 66% | 55.8824% | 70.5882% |
Results of attribute selection splitting images into 4 parts.
Table 5 also shows a 100% of correctly classified instances for both classifiers under use training set test option. Under cross validation, Naïve Bayes classifies equal amount of correctly classified instances selecting 29 attributes as selecting all of them, similar situation occurred with J48 with 1% greater for selecting all of the attributes. Finally, under percentage split both of the classifiers perform better selecting 29 attributes.
Classifier | Test options | ||
NaiveBayes | use training set | 100% | 100% |
J48 | use training set | 100% | 100% |
NaiveBayes | cross validation folds 10 | 97% | 97% |
J48 | cross validation folds 10 | 85% | 84% |
NaiveBayes | percentage split 66% | 88.2353% | 94.1176% |
J48 | percentage split 66% | 64.7059% | 73.5294% |
Results of attribute selection splitting images into 16 parts.
Table 6 shows once again a 100 % of correctly classified instances under use training set test option for both cases of attribute selection. Under cross validation and percentage split both of the classifiers perform better selecting 116 attributes.
Classifier | Test options | ||
NaiveBayes | use training set | 100% | 100% |
J48 | use training set | 100% | 100% |
NaiveBayes | cross validation folds 10 | 94% | 96% |
J48 | cross validation folds 10 | 85% | 89% |
NaiveBayes | percentage split 66% | 88.2353% | 94.1176% |
J48 | percentage split 66% | 64.7059% | 76.4706% |
Results of attribute selection splitting images into 64 parts.
Table 7 shows that J48 performs better than Naïve Bayes without splitting images but not in a significant way. Considering any other splitting image scheme or attribute selection show a 100 % of correctly classified instances.
Classifiers | |||
Attributes | Parts | NaiveBayes | J48 |
All of them | 1 | 94% | 97% |
30% | 1 | 90% | 92% |
All of them | 4 | 100% | 100% |
30% | 4 | 100% | 100% |
All of them | 16 | 100% | 100% |
30% | 16 | 100% | 100% |
All of them | 64 | 100% | 100% |
30% | 64 | 100% | 100% |
Results of classifiers effectiveness under use training set.
Table 8 shows Naive Bayes performs better than J48 for any splitting image scheme and attribute selection.
Classifiers | |||
Attributes | Parts | NaiveBayes | J48 |
All of them | 1 | 85% | 71% |
30% | 1 | 72% | 69% |
All of them | 4 | 90% | 86% |
30% | 4 | 93% | 83% |
All of them | 16 | 97% | 85% |
30% | 16 | 97% | 84% |
All of them | 64 | 94% | 85% |
30% | 64 | 96% | 89% |
Results of classifiers effectiveness under cross validation.
Table 9 shows Naïve Bayes performs better than J48 except for selecting best 30% attributes without splitting images. Experiments of splitting images into parts allow concluding that splitting images into 16 parts is enough for satisfactory classification. Statement from previous paragraph can be asserted due to results in Table 1 show splitting images into 64 parts obtains equal amount of correctly classified instances as performing such split into 16 parts, Table 1 even shows a reduction of 3% in correctly classified instances for NaiveBayes classifier under cross validation. Next stage of experiment consisted on selecting best 30% attributes, which reveals Naïve Bayes generates greater amount of correctly classified instances from splitting images into 16 parts, J48 obtains 5% better in 64 parts under cross validation and 2.9412% in 64 parts under percentage split. Due to improvement for 64 parts is not significant, it is concluded splitting into 16 parts is enough. Experiments of attribute selection allow concluding that selecting best 30% is enough. This can be validated from both table 1 and table 2 which show that splitting images into 64, 16, and 4 parts selecting best 30% obtains greater amount of correctly classified instances than considering all attributes. J48 throws 1% better for splitting into 16 parts and 3% better into 64 parts with all attributes, but this is disregarded due to it is not significant. Experiments analyzing effectiveness of classifiers allow to conclude Naïve Bayes performs better due to it obtains greater amount of correctly classified instances under most splitting images case and test option except for use training set test option and no splitting images.
Classifiers | |||
Attributes | Parts | NaiveBayes | J48 |
All of them | 1 | 76.4706% | 64.7059% |
30% | 1 | 58.8235% | 61.6747% |
All of them | 4 | 70.8552% | 55.8824% |
30% | 4 | 88.2353% | 70.5882% |
All of them | 16 | 88.2353% | 64.7059% |
30% | 16 | 94.1176% | 73.5294% |
All of them | 64 | 88.2353% | 64.7059% |
30% | 64 | 94.1176% | 76.4706% |
Results of classifiers effectiveness under percentage split.
A field that is becoming a rich area for the application of data mining is that of medical imaging. The tremendous advance in imaging technologies such as X-rays, computed tomography, magnetic resonance, ultrasound and positron emission tomography has led to the generation of vast amounts of data (Figure 5). Scientists are interested, of course, in learning from this data, and data mining techniques are increasingly being applied in these analyses.
There are interesting techniques for finding and describing structural patterns in data as a tool for helping to explain that data and make predictions from it. The data will take the form of a set of examples from the patients. The output takes the form of predictions about new examples. Many learning techniques look for structural descriptions of what is learned, descriptions that can become fairly complex and are typically expressed as sets of rules. Because they can be understood by people, these descriptions serve to explain what has been learned and explain the basis for new predictions. People frequently use data mining to gain knowledge, not just predictions. Databases are rich with hidden information that can be used for intelligent decision making. Classification and predictions are two of data analysis that can be used to extract models describing important data classes or to predict future data trends. Such analysis can help provide us with a better understanding of the data at large.
Examples of medical imaging. (a) Ultrasound. (b) A-rays. (c) Magnetic resonance. (d) Computed tomography.
A medical research wants to analyze breast cancer data in order to predict which one of three specific treatments a patient should receive. In the example, the data analysis task is classification, where a model o classifier is constructed to predict categorical labels, such as treatment A, treatment B, or treatment C for the medical data. These categories can be represented by discrete values, for example, the values 1, 2, and 3 may be used to represent treatment A, B, and C.
The implementation methods discussed are particularly oriented toward show different tools for analyzes medical data.
Decision tree induction is the learning of decision trees from class-labeled training tuples. A decision tree is a flow-chart-like tree structure, where each internal node (nonleaf node) denotes a test on an attribute, each brand represents an outcome of the test, and each leaf node (or terminal node) holds a class label. The topmost node in a tree is the root node. The learning of decision trees from class-labeled training tuples is named decision tree induction. A decision tree can be viewed as a flow-chart-like tree structure, where each internal node (nonleaf node) represents a test on an attribute, each brand represents an outcome of the test, and each leaf node (or terminal node) holds a class label. The root node is the principal node (highest node) in a tree.A typical decision tree is shown below (Figure 6).
Decision Tree Induction
ID3 is an algorithm which generates a decision tree based on input data by looking at the amount of information contents contained in the various input attributes. At each step in the decision tree, it chooses the attribute which provides the biggest information gain and uses that attribute to classify data further. Its pseudo code is summarized as follows:
Like an example, the input and output variables and their domains are specified in the list below:
Input variables (from clinical observations):
Extent (Size of Spreading): {E1, E2, E3, E4}
Hypoxia: {H1, H2}
Surface (surface marker): {S1, S2, S3}
LOH: {M1, M2, M3}
Final result/outcome:
Outcome: {P (progressed to cancer), NP (didn’t progress to cancer)}
The ID3 algorithm as implemented and the following decision tree are generated (Figure 7):
Decision Tree Induction for the medical data.
The decision tree method produces a reasonably good estimate on the outcome based on the inputs. This estimate is about 92% accurate, which is above the acceptable level of accuracy as proposed by the clinical researchers.
An artificial neural network (ANN) is a computational model that is inspired by the structure and functional aspects of biological neural networks. They are usually used to model complex relationships between inputs and outputs and find patterns in data. In other words, we wish to infer the mapping implied by the data. The cost function is related to the mismatch between our mapping and the desired outcome. One very commonly used approach to train neural network from input examples is the back-propagation algorithm. Back-propagation algorithm is a common supervised-learning method that teaches an artificial neural network on how to perform a given task. The neural network is modeled as a set of neurons which take inputs, apply certain weights to each input and propagate the result forward into the next layer of units. Each unit in a particular layer is essentially a linear function of the input units from its previous layer. Eventually, the data gets propagated into the output layer where the results are presented.
Another important aspect is this algorithm is able to learn by propagating the errors in the output layer backwards into the inner layers by adjusting the weights between the input and hidden layer and between hidden and output layer in order to reduce the error on the output. The algorithm continues to do this until either the maximum number of epochs is reached or the errors at the output are within an acceptable range. This technique is also referred to as “back-propagation”, as denoted in its name. A very typical neural network consists of 3 layers – input, hidden, and output layer. In practice, it is possible to have more than one hidden layers. The back-propagation algorithm used for this project is based on such a 3-layer neural network as illustrated in the figure 8.
The pseudo code for the back-propagation algorithm is as follows:
A simple neural network.
The output from the neural network is a simple binary value {0, 1} representing whether or not the patient’s tumor progresses into malignant cancer. the classification boundary value to be the half-way point 0.5, so if the neural network’s output value turns out to be above 0.5, it is categorized as 1; and values below 0.5 gets categorized as 0. The next important step is to determine the appropriate number of hidden variables in the neural network to avoid both under-fitting and over-fitting. The number of hidden variables should be strictly less than the number of inputs to the neural network, which is 4 in this case.
The naïve Bayesian classifier makes the assumption of class conditional independence, that is, given the class label of tuple, the value of the attributes are assumed to be conditionally independent of one other. This simplifies computation. When the assumption holds true, then the naïve Bayesian classifier is the most accurate in comparison with all other classifiers. However, dependencies can exist between variables. Bayesian networks specify joint conditional probability distributions. They allow class conditional independencies to be defined between subsets of variables. They provide a graphical model of causal relationships, on which learning can be performed. The learning can be perfomed in the graphical model of causal relationships, that they provide. Trained Bayesian belief networks can be used for classification.
A belief networks is defined by two components –a directed acyclic graph and a set of conditional probability tables (e.g., Figure 9). Each node in the directed acyclic graph represents a random variable. The variables may b discrete o continuous-valued. They may correspond to actual attributes given in the data to form a relationship (e.g., in the case of medical data, a hidden variable may indicate a syndrome, representing a number of symptoms that, together, characterize a specific disease). Each arc represents a probabilistic dependence. If an arc is drawn from a node
A example of Bayesian Network.
The Figure 10 is a simple Bayesian network for six Boolean variables. The arcs in figure 10 (a) allow the representation of causal knowledge. For example, having lung cancer is influenced by a person’s family history of lung cancer, as well as whether or not the person is a smoker. The arcs also show that the variable
A simple Bayesian network: (a) A proposed casual model, represented by a acyclic graph. (b) The conditional probability table for the value of the variable LungCancer (LC) showing each possible combination of the values of its parents nodes,
A belief network has one conditional probability table (CPT) for each variable. The CPT for a variable Y specifies the conditional distribution
A node within the network can be selected as an “output” node, representing a class label attribute. There may be more than one output node. Various algorithms for learning can be applied to the network. Rather than returning a single class label, the classification process can return a probability distribution that gives the probability for each class.
Visual data mining discovers implicit and useful knowledge from large data Visual data mining have the capacity to find implicit and useful knowledge from great amount of data sets using data and/or knowledge visualization techniques. The human visual system is controlled by the eyes and brain, the latter of which can be thought of as a powerful highly parallel processing and reasoning engine containing a large knowledge base (Figure 11). Visual data mining essentially combines the power of these components, making it a highly attractive and effective tool for the comprehension of data distribution, patterns, clusters, and outliers in data. the eyes and brain, the latter of which can be thought of as a great highly parallel processing and reasoning engine that contain a large knowledge base (Figure 11). Visual data mining combines the power of these components, making it a highly attractive and effective tool for the comprehension of data patterns, clusters, distribution and outliers in data.
Human interact and processing large knowledge base.
Visual data mining can be viewed as an integration of two disciplines: data visualization and data mining. It is also closely related to computers graphics, multimedia systems, human computer interaction, pattern recognition, and high-performance computing. In general, data visualization and data mining can be integrated in the following ways:
Visual data mining can be viewed as an integration of two disciplines: data visualization and data mining. It is also closely related some disciplines: human computer interaction, pattern recognition, high-performance computing, computers graphics and multimedia systems. Data mining and data visualization can be integrated in the next ways:
Data visualization: Data in a database or data warehouse can be view at different levels of granularity of abstraction, or as different combination of attributes or dimensions. Data can be presented in various visuals forms, such a boxplot, 3-D cubes, data distribution charts, curves, surfaces, link graphs, and so on. An example represented below:
Data visualization: Data in a database or data warehouse can be view at different levels of granularity of abstraction, or as different combination of attributes or dimensions. Data can be presented in various visuals forms, such a data distribution charts, boxplot, curves, 3-D cubes, link graphs, surfaces, and so on. An example represented below:
Boxplots showing multiple variable combinations in datasets.
Data mining result visualization: Visualization of data mining results is the presentation of results or knowledge obtained from data mining in visual forms. Such forms may include scatter plots and boxplots, as well as decision tree, clusters, outliers, generalized rules and so on (Figure 9).
Data mining result visualization: It means use techniques with which is possible the visual representation of results or knowledge that is obtained from data mining process. Such vicual forms may include scatter plots and boxplots, decision tree, clusters, outliers, generalized rules and so on (Figure 13).
Visualization on data mining results.
Interactive visual data mining: In visual data mining, visualization tools can be used in the data mining process to help users make smart data mining decisions. For example, the data distribution in a set of attributes can be displayed using colored sectors (where the whole space is representing by a circle). This display helps users determine which sector should first be selected for classification and where a good split point for this sector may be.
The data mining process can be supported by visualization tools to help users to make smart data mining decisions. For example, in a circle that represents a whole space, the data distribution in a set of attributes can be displayed using colored sectors. With this visual representation the users can determine which sector should first be selected for classification and where a good split point for this sector may be.
Example for circular data representation.
The concept also is used to describe to the set of the characteristics that characterize to somebody or something. In the case of the human beings, the profile is associate to the personality. On the other hand, the word profile also is used very many to designate those particular characteristics that characterize a person and by all means they serve to him to be different itself from others. Your profile is built on other people’s impressions and opinions, from the first time they hear your group’s name or come into contact with one of its members. To some extent, you can control what people think and feel about your group, building a strong profile that will help you achieve action success. See Figure 15.
Orkut is a system of social networks used in Brazil by 13 million users, many of them, create more of a profile, and generate different relationships from their different profiles, this takes to think that they develop Bipolar Syndrome, to be able to establish communications with people of different life styles, and when they doing to believe other users that they are different people (Zolezzi-Hatsukimi, 2007).
The false profiles are created for: to make a joke, to harass other users, or to see who visualizes its profile. As the profile is false, the friends of this profile are also generally false, making difficult the tracking of the original author (Ochoa et. al., 2011). Using the tool of Data Mining denominated WEKA, it was come to develop a denominated "Ahankara" Model which perits reaize prediction of profiles in users of Orkut, which al-lows to understand the motivations of this type of profile and to determine if it has generated Syndrome Bipolar, to see figure 3 (Ponce et al., 2009). The model obtained Ahankara once used WEKA to look for the relations that us could be of utility to process the data. see Figure 16.
The profile show characteristics of a person or a group of people
Ahankara Model
Waste. It is something that we produce as part of everyday living, but we do not normally think too much about our waste. Actually many cities generates a waste stream of great complexity, toxicity, and volume (see figure 17). In the management of solid waste have the problem relates to the household waste is the individual decision-making over waste generation and disposal. When the people decide how much to consume and what to consume, they do not take into account how much waste they produce (Ochoa et al., 2011).
E-commerce is the term use to describe the consumers that use the Internet for making purchases, usually refers typically to business to business type activities rather than consumer activity. It maybe more appropriate to refer to consumer activity in relation to purchasing goods and services on the Internet as on-line shopping (see figure 18). E-commerce is the term use to describe the consumers that use the Internet for making purchases, generally refers activities thath involve some business between two or more entities, rather than only consumer activity. This is more related to purchasign goods and services on the Internet rather than on-line shopping (see figure 18).
Example of composition by weight of household garbage
One of the important factors in the world of E-commerce is that it is much more than just a change in the way payments are made; E-commerce may not involve money at all. It gives customers the choice of making a wide range of transactions electronically rather than over the telephone, by post or in person. The E-commerce is not only a different way that the people use to pay for any thing, because, it is not simply money; this implies transactions that could be done by telephone, by post or in person, which the costumer can done electronically.
The people can buy services or things online
The major benefits of E-commerce are that it can help organizations to:
improve working processes and service delivery;
understand their customers better; and
reduce costs through elimination of paperwork and bureaucracy.
Some of the most important benefits of E-commerce for the organizations are:
The service delivery and the working process are improved.
The organizations can understand their customers.
They can reduce the costs caused by paperwork and bureaucracy.
In the e-commerce we has two different profile, the buyers and salesman profile, in this case we work with the buyers profile, In (Cocktail Analysis and Google, 2011) is sow a research about the buyers of fashionable clothes, in this work we can see that 42% of the people they have bought some article of clothes by Internet. They describe five different profiles only for the buyers of clothes, also it shows the relation of the purchases online with those of the physical stores. Data mining process can be used to determine the buyers profile, the enterprise can use this information to realize market studies in order to offer to the people specific products to them on the basis of its profile of purchases. Also the analysis of profiles is very important like dominion application of the data mining, can help to determine landlords us of conducts, habits, or of a single person or of a group, these data allow us to make predictions and can be used of diverse ways.
The e-commerce is one of the profound changes that internet has induced in the people’s lifestyle and in the way of doing business and transactions. The way that the consumers buy has been modified, appearing trends, patterns and preferences in specific groups. Some characteristics that can affect the consumerism by internet are: gender, age, social status, economic status, financial status, studies, culture, technology, knowledge of technology, geographic location, politics and others. In the early years of e-commerce, buying online was an erudite activity strictly dominated by “techies” and semi-technology literate individuals. These individuals were mostly made up of 20 to 35 year old males. This demographic were more comfortable and in tune with Internet’s capabilities. But in recent years, the numbers of females making the technology leap to shop online is surging. Females are starting to harness Internet to make their lives easier and efficient (Christopher, 2004). In the early years of e-commerce, buying online was an erudite activity. The individuals were mostly made up of 20 to 35 year old males. In recent years, the numbers of females making the technology leap to shop online is surging. (Christopher, 2004). Data Mining (DM) has been applied successfully to find the patterns that the consumers create in the navigation trough the different web sites giving the opportunity to the enterprises to offer a better service.
In the e-commerce, the behavior of the consumers creates trends that change in the time for different variables. (Audette, 2010), mention three important trends in 2010 that should be considered by the people involved in the e-commerce (brands, retailers, and others).
The consumer always is looking for the lowest prices, it means, the best product for the best price or sometimes only the best price.
The consumer also looks for special offers that can balance that price was not the lowest. The offers can be the free shipping.
It’s very important now a day, the visual experience in the e-commerce because it is more attractive for the consumer and can be a reason to decide to buy something. The people spend a lot of time watching videos. A case is Mexico where the viewers watched 5 hours of video in YouTube in September 2011, and the audience has grown 17% to reach 20.5 million viewers, representing 85% of the total online population, according to a study by comScore. The next graphic shows video properties that prefer the viewers in Mexico.
Top Video Properties in Mexico by Total Unique Viewers 2011
The video experience can improve the process information in a 30%, according Bing, and this can be explained because 65% are visual learners.
Buying Power Index 2010
SEO (Search Engine Optimization) is a technique which helps search engines find and rank your site higher than the others millions in response to a search query. This is based primarily in text. Google Instant had a little noticeable effect in the ecommerce clients.
Data Mining (DM) have been applied to study the behavior of the users of different services (entertainment, mail, e-commerce, social network, among others) that internet provides. Many enterprises like Amazon and eBay have invested many resources to understand the consumers. Authors like (Sankar et al., 2002) explain why Web Mining, concept used for the first time by (Etzioni, 1996), is considered like sub-field of Data Mining. They say that Web Mining can be defined as “the discovery and analysis of useful information from the World Wide Web”. The source of data can be the server, client, proxy server, or data bases of some enterprise. The web mining is divided in: Web content mining, Web structure mining, Web usage mining (Sankar et al., 2002). The principal tasks/phases of Web mining are: Information retrieval (resource discovery), information extraction (selection/preprocessing), Generalization (pattern recognition/machine learning), Analysis (validation/interpretation).
Tasks of Web Mining
The Data Mining, or in this case Web mining, which is known, needs some problems with certain characteristics to obtain the major benefits. Those characteristics are (Ansari, Suhail, 2000):
Large amount of data
Rich data with many attributes
Clean data collection
Actionable domain
Measurable return-on-investment
The e-commerce has every characteristics being a “Killer Domain” of Data Mining (Ansari, Suhail, 2000). The attributes more important in the e-commerce are RFM (Recency, Frequency and Monetary). Examples of these attributes are date, time, duration session, quantity, purchase (Ansari, Suhail, 2000). Other attributes are IP address, URL, error code, among others; however these are common in logs that are not created for analysis (De Gyves Camacho, 2009). The attributes (columns) related with time and date are used to find important hidden patterns. One of the applications of Web mining is the learning of Navigation patterns (Web usage Mining).
The Artificial Immune System (AIS) is a bio-heuristic based in the Natural Immune System (NIS). One of the characteristics that make interesting the NIS are: highly distributed, highly adaptive, self-organising, maintain a memory of past encounters, and learn of new encounters. Some algorithms that have been proposed to use in data mining, are based in theories like negative selection, clonal selection and immune network. However new algorithms have been created inspired in other characteristic or theories. In order to approximate a solution of the learning of navigation patterns an immune-inspired algorithm is proposed which is based in the immune network and was developed by (Timmis et al., 2000). The AIS has some characteristics that can be improved but is good for a first approximation. This algorithm is proposed to clustering the similarities of the users’ behavior and according of the pattern, in a next step, suggest the best structure of the web site to the consumers to improve their experience. In this way, the companies con offer a better service, adapted to the consumers’ necessities and finally increase sales.
Mobile radio technologies, for both voice and data communication, has experienced a rapid growth and diverse concepts have been introduced in networking. However the concept of ad hoc network is not new, the paradigm started from the beginning of late 90‘s and gradually became popular with the wide range of deployments of IEEE 802.11x based WLAN, despite regularly ad hoc networks are based on single-hop peer-to-peer networking between several wireless devices, in different specialized scenarios such as control applications, logistics and automation, surveillance and security, transportation management, battlefields, environmental monitoring, unexplored and hazardous conditions, home networking, etc. multi-hop wireless networks are used. Multi-hop wireless ad hoc network consists of a number of self-configurable nodes (e.g. IEEE 802.11-based WLAN, 802.16-based WiMAX, ZigBee, Bluetooth, etc.) to establish an on-demand network using multiple hops paths if required where no network infrastructures pre-exist. The basic block of multi-hop ad hoc networking can be divided into four major specialized categories – Mobile Ad hoc Networks (MANET), Wireless Mesh and Hybrid Networks (WMN), Vehicular Ad hoc Networks (VANET) and Wireless Sensor Networks (WSN) (Kamal, 2010). MANET is the most theoretically researched arena of ad hoc networking which is a collection of autonomous and mobile network objects of any kind with truly dynamic and uncertain mobility that communicate with each other by forming a multi-hop radio network and maintaining connectivity in a decentralized manner. Nowadays, MANET has become a practical platform for pervasive services, i.e., the services that are requested and provided anywhere and anytime in an instant way. This kind of service is very valuable for mobile users, especially when fixed networks (e.g. Internet) or mobile networks are temporarily unavailable or costly to access. A generic concept of the general-purpose pure MANET is shown in Figure 22.
In Figure 22, let’s suppose that node A wants to send data to node C but node C is not in the range of node A. Then in this case, node A may use the services of node B to transfer data since node B’s range overlaps with both the node A and node B. In MANET, no fixed infrastructure, like base station or, mobile switching center is required. Instead, every possible wireless mobile host within the perimeter of radio link acts as an intermediate switch and participates in setting up the network topology in a self organized way.
A Simple MANET
Despite the advantages, accord to Nakkeeran, the nature of mobility creates new vulnerabilities due to the open medium, dynamically changing network topology, cooperative algorithms, lack of centralized monitoring and management points and yet many of the proven security measures turn out to be ineffective (Nakkeeran et al., 2010). Despite the advantages, accord to Nakkeeran, the nature of mobility creates new vulnerabilities due to the open medium, dynamically changing network topology, cooperative algorithms, lack of centralized monitoring and management points and yet many of the proven security measures turn out to be ineffective (Nakkeeran et al., 2010). All these mean that a wireless ad-hoc network will not have a clear line of defense, and every node must be prepared for encounters with an adversary directly or indirectly. In order to avoid such circumstances requires the development of novel architectures and mechanisms that protect wireless networks and computer applications. Hence diverse research scopes do exist. Unfortunately, investigations are principally targeted towards routing, scheduling, address assignment, developing protocol stack etc. These are mainly functional properties. However, as nomadic and ubiquitous computing reaches its full potential, semantics and security will play the leading role, because the flexibility in space and time induces new challenges towards the security infrastructure. Due to in the case of the securtiy infraestructure, the flexibility in space and time will generate new challenges. Therefore, the traditional way of protecting wired/wireless networks with firewalls and encryption software is no longer sufficient. A very recurrent solution are Intrusion Detection Systems (IDS) (Mishra, 2004). Generally IDS can be defined as the detection of intrusions or intrusions attempts either manually or via software, through the use of schemes that collects the information and analyzing it for uncommon or unexpected events. Intrusion Detection (ID) is the process of monitoring and analyzing the events which occurred in a digital network in order to detect signs of security problems (Shirbhate, 2011). Then the ID is data analysis process, for this reason, as well as the growth of volume of existing data and insufficiency of data storage capacity leads us to the dynamic processing data and extracting knowledge. So the nature solution is utilizing data mining techniques, for example, anomaly detection techniques could be used to detect unusual patterns and behaviors, link analysis may be used to trace the viruses to the perpetrators, classification may be used to group various cyber attacks and then use the profiles to detect an attack when it occurs, prediction may be used to determine potential future attacks depending in a way on information learnt about terrorists through email and phone conversations (Khalilian, 2011). Data mining can improve variant detection rate, control false alarm rate and reduce false dismissals (Jianliang, 2009).
If we want to categorize intrusion detection methods, we will recognize two main aspects for grouping approaches, which one group refers to type of attack according to the kind of input information the analyze includes host based, network based, wireless and Network Behavior Analysis (NBA). Another group of approaches refers to solutions techniques which are misuse detection, anomaly detection methods and hybrid methods (Khalilian, 2011).
Host based methods.
This methods are based on data source category; consequently, its data comes from the records of various activities of hosts, including system logs, audit operation system information, etc. the main architecture for this kind of methods is similar to network based.
Network based methods.
These systems analyze network packets that are captured on a network. Network packet is the data source for network intrusion detection system.
Wireless methods.
Wireless intrusion detection system monitors wireless network traffic and analyzes its wireless networking protocols to identify suspicious activity involving the protocols themselves. It cannot identify suspicious activity in the application or higher-layer network protocols such as TCP, UDP that the wireless network traffic is transferring. So each node is responsible for detecting signs of intrusion locally and independently, but neighboring nodes can collaboratively investigate in a broader range.
Network Behavior Analysis.
NBA which examines network traffic to identify threats that generate unusual traffic flows, such as distributed denial of service (DDoS) attacks, certain forms of malware such as worms, backdoors, and policy violations. NBA systems are also deployed to monitor flows on an organization’s internal Networks, and are also sometimes deployed where they can monitor flows between an organization’s Networks and external networks such as the Internet.
Figure 23 shows the basic architecture for NIDS in data mining, which is very similar to the other detection methods
Basic NIDS architecture
Misuse based methods.
Misuse detection which the main study is the classification algorithms relies on the use of specifically known patterns of unauthorized behavior. In misuse detection related problems, standard data mining techniques are not applicable due to several specific details that include dealing with skewed class distribution, learning from data streams and labeling network connections. The problem of skewed class distribution in the network intrusion detection is very apparent since intrusion as a class of interest is much smaller i.e. rarer than the class representing normal network behavior. In such scenarios when the normal behavior may typically represent 98-99% of the entire population a trivial classifier that labels everything with the majority class can achieve 98-99% accuracy (Dokas, 2002). It is apparent that in this case classification accuracy is not sufficient as a standard performance measure. ROC analysis and metrics such as precision, recall and F-value have been used to understand the performance of the learning algorithm on the minority class. A confusion matrix as shown in Table 1 is typically used to evaluate performance of a machine learning algorithm.
Confusion matrix (Standard metrics) | Predicted connection label | ||
Normal | Intrusions (Attacks) | ||
Actual connection label | Normal | True Negative (TN) | False Alarm (False Positive) |
Intrusions (Attacks) | False Negative (FN) | Correctly Detected Attacks (True Positive) |
Standards metrics for evaluations of intrusions (attacks)
In addition, intrusions very often represent sequence of events and therefore are more suitable to be addressed by some temporal data mining algorithms. Finally, misuse detection algorithms require all data to be labeled, but labeling network connections as normal or intrusive re-quires enormous amount of time for many human experts. All these issues cause building misuse detection models very complex.
Anomaly based methods.
Misuse detection system unable to detect new or previously unknown intrusions occurred in computer system or digital network. Novel intrusions can be found by anomaly detection which the main study is the pattern comparison and the cluster algorithms ((Khalilian, 2011). The basic idea of clustering analysis originates in the difference between intrusion and normal pattern; consequently, we can put data sets into different categories and detect intrusion by distinguish normal and abnormal behaviors. Clustering intrusion detection is detection for anomaly with no supervision, and it detects intrusion by training the unmarked data.
Most anomaly detection algorithms require a set of purely normal data to train the model, and they implicitly assume that anomalies can be treated as patterns not observed before. Since an outlier may be defined as a data point which is very different from the rest of the data, based on some measure. In statistics-based outlier detection techniques the data points are modeled using a stochastic distribution and points are determined to be outliers depending upon their relationship with this model. However, with increasing dimensionality, it becomes increasingly difficult and inaccurate to estimate the multidimensional distributions of the data points. However, recent outlier detection algorithms are based on computing the full dimensional distances of the points from one another as well as on computing the densities of local neighborhoods. Nearest Neighbor (NN), Mahalanobis-distance Based Outlier Detection and Density Based Local Outliers (LOF) are approaches for recent outlier detection algorithms.
Hybrid methods.
Through analyzing the advantages and disadvantages between anomaly detection and misuse detection, a mixed intrusion detection system (IDS) model is designed. First, data is examined by the misuse detection module, and then abnormal data detection is examined by anomaly detection module. The intrusion detection system (IDS) is designed based in the advantages and disadvantages of the models of intrusion detection that are: anomaly detection and misuse detection. The first step is examine the data with de misuse detection module and in the second step, the anomaly detection module analyze the atypical data detected.
The ultimate goal of the security solutions for wireless networks is to provide security services, such as authentication, confidentiality, integrity, anonymity, and availability, to mobile users. The final goal of the security solutions for wireless networks is to offer security services to mobile users. This services are authentication, integrity, confidentiality, anonymity, and availability.This kind of schemes depend on cooperation amongst the nodes in a MANET for identifying nodes that are exhibiting malicious behaviors such as packet dropping, packet modification, and packet misrouting, so most of this methods assume that this problem can be viewed as an instance of detecting nodes whose behavior is an outlier when compared to others. Some novel solutions incorporate mobile agents (Nakkeeran et al., 2010) to provide solution against security issues in MANET networks. With the help of home agent and mobile agents, it gathers information from its own system and neighboring system to identify any attack and through data mining techniques to find out the attacks has been made in that networks.With the help of home agent and mobile agents, it is possible to extract information from both, own system and neighbor system, to identify any attack and with data mining techniques try to find the attacks that has been perpetrated in such networks. Home agent is present in each system and it gathers information about its system from application layer to routing layer.
Each system have a home agent, which should obtain iformation about the system from application layer to routing layer.
Mobile agents are a special type of agents defined as "processes capable of roaming through large networks such as the ad hoc wireless network, interacting with machines, collecting information and returning after executing the tasks adjusted by the user". Mobile agents are a special type of agents defined as "processes capable of roaming through large networks such as the ad hoc wireless network, interacting with machines, which return the colected information when finishing the execution of the tasks of the user". Often such proposals provide the three different techniques to provide suffice security solution to current node, Neighboring Node and Global networks.
Frequently, the proposals afford the three differents techniques that are used to offer security solution to current node, Neighboring and Global networks.
The trust together cooperation are another kind of novelty solution (Li, 2009); the idea of them consists in an algorithm to can help us identify the outliers, which are generally the nodes that have exhibited some kind of abnormal behaviors. Given the fact that benign nodes rarely behave abnormally, it is highly likely that the outliers are malicious nodes. Moreover, a multi-dimensional trust management scheme is proposed to evaluate the trustworthiness of the nodes from multiple perspectives. There are many techniques that have been discussed to prevent attacks in wireless ad hoc networks but most of them have in common that are based on cooperation and on methods based on the principle of anomalies.
Diverse applications based on Data Mining have the objective to learn the patterns of the users’ interaction with the Web or Data Repository. The data includes user profiles, registration profiles, user queries, and any data generated by the users’ interaction with the web. This is useful, for example, to restructure the web page according the preferences of the users. This means that the web site is going to provides information, special offers, and others, that can be interesting for the consumers according their patterns of interaction or according the hour of the day. Also, this can be used to design offline strategies. One process to make projects of web usage mining is described in (DAEDALUS, 2002). To find the patterns in Web usage mining, the techniques used are: Clustering and Classification, Association rule detection, Path analysis, Sequential patterns detection. The use of any technique mention above to analyze automatically the data implies difficulties by the complexity of the problem (heterogeneous data, and others) and the limitations of the existing methodologies. To overcome that difficulties and limitations is necessary to use other techniques and methodologies like soft computing. Some algorithms developed to address Data Mining using techniques of Soft Computing are revised by (Mishra el al., 2004). Other application of Data Mining using evolutionary algorithms were proposed by (Ochoa et al., 2011) obtaining good results. In addition, we described another specfic applications domains such as: Deterining Euskadi ancesters based on family names and compare the anthropmetry of the individuals to found patterns of their ancesters; Organizational Models to supporting little and medium business related with Regional Development; Organizational Climate to identify cases of Burnout Syndrome characterized by high expectatives of productivty and Organizational Culture (Hernández et al, 2011); Identification of the use of new languages related with the songs from Eurovision for exameple Udmurt language in the entry from Russia to Eurovision Song Contest’2012; Analysis of Pygmalion Effect on people from Pondichérry in India whom be considering more closely culturally of Francophonie because the French influence in their past lifes; Zoo applications to classify more vulnerable species in an interactive map (see figure 24) or identify the adequate kind of avatars on a roll multigame players associated with cultural aspects in this case Brazilian people and their selections of features related with spcific skills (see figure 25).
Interactive map based on data mining, locating the habitats of species of reptils, birds and mammals specifying the ubiquity of their behavior –changes provoked by the human- during the time.
Cultural Avatars related with traditional aspects and antropometry from Brazlian people used in Multi player games according of specific skills used on the online game.
In addition Tatebanko traditional Japanese Dyoram is using new ideas based with a Hybrid Algorithm conformed by the use of Data Mining and a Bioinspired Algorithm to built 3D scenario (Ochoa et al., 2012) including issues of specific time and location by each one.
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On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. His research interests include pattern recognition, bioinformatics, and biometric systems (fingerprint classification and recognition, signature verification, face recognition).",institutionString:null,institution:null},{id:"496",title:"Dr.",name:"Carlos",middleName:null,surname:"Leon",slug:"carlos-leon",fullName:"Carlos Leon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Seville",country:{name:"Spain"}}},{id:"512",title:"Dr.",name:"Dayang",middleName:null,surname:"Jawawi",slug:"dayang-jawawi",fullName:"Dayang Jawawi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Technology Malaysia",country:{name:"Malaysia"}}},{id:"528",title:"Dr.",name:"Kresimir",middleName:null,surname:"Delac",slug:"kresimir-delac",fullName:"Kresimir Delac",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/528/images/system/528.jpg",biography:"K. 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The ambiguities surrounding of the digital currency still leave enough space for the analysis of its unreserved acceptance, trust and anticipation, which are the main driver for the spread of the network. Banks should carefully consider the technology underlying these cryptocurrencies as a potential generic new way of transferring ownership of the value over the long term. The chapter provides an analysis of the use of cryptocurrencies in general, especially Bitcoin as the technology adoption in the presence of network externalities. The objective attitude is the future of the digital currency in the moment is still unsolved issue due to the existence of “critical mass”. Further, the chapter explores financial privacy which is very sensitive issue in using digital currency (or cryptocurrency) and discuss about private choices versus political rules. The research has shown that the future of cryptocurrencies can be bright if some institutional-formal conditions are met due to the fact that success evolution of e-money requires building safety payments through three criteria–standardization, compatibility and innovation.",book:{id:"7228",slug:"blockchain-and-cryptocurrencies",title:"Blockchain and Cryptocurrencies",fullTitle:"Blockchain and Cryptocurrencies"},signatures:"Tatjana Boshkov",authors:[{id:"246137",title:"Ph.D.",name:"Tatjana",middleName:null,surname:"Boshkov",slug:"tatjana-boshkov",fullName:"Tatjana Boshkov"}]},{id:"38793",title:"Overview of Wireless Sensor Network",slug:"overview-of-wireless-sensor-network",totalDownloads:12499,totalCrossrefCites:63,totalDimensionsCites:86,abstract:null,book:{id:"2211",slug:"wireless-sensor-networks-technology-and-protocols",title:"Wireless Sensor Networks",fullTitle:"Wireless Sensor Networks - Technology and Protocols"},signatures:"M.A. Matin and M.M. Islam",authors:[{id:"12623",title:"Prof.",name:"Mohammad Abdul",middleName:"A",surname:"Matin",slug:"mohammad-abdul-matin",fullName:"Mohammad Abdul Matin"}]},{id:"66938",title:"An Overview of Wireless Mesh Networks",slug:"an-overview-of-wireless-mesh-networks",totalDownloads:1693,totalCrossrefCites:2,totalDimensionsCites:5,abstract:"Wireless mesh networks (WMNs) are communication networks which comprise radio nodes in which nodes are arranged in a mesh topology. Mesh topology is an interconnection of all nodes connected with all other nodes in the network. The network includes devices like nodes, clients, routers, gateways, etc. As the nodes are fully connected, mesh networks are usually less mobile as rerouting is less difficult in predicting the reroute results in delay in data transmission. Mesh clients can be of any wireless devices like cell phones, laptops, etc. The gateways which act as forwarding nodes may not be connected with the Internet. As different devices come under a single network, it is also referred as mesh cloud. WMN is self-healable. It works better with various different networks which include cellular networks and IEEE 802.11, 802.15, and 802.16 as well. WMN is flexible to work with more than one protocol. This chapter gives architecture, layer functionalities, and applications.",book:{id:"7322",slug:"wireless-mesh-networks-security-architectures-and-protocols",title:"Wireless Mesh Networks",fullTitle:"Wireless Mesh Networks - Security, Architectures and Protocols"},signatures:"J. Rejina Parvin",authors:null},{id:"63090",title:"Cryptocurrency Returns",slug:"cryptocurrency-returns",totalDownloads:1471,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"One of the most significant innovations in the world of finance has been the creation and evolvement of cryptocurrencies. These digital means of exchange have been the focus of extensive news coverage, especially the Bitcoin, with a primary focus on the tremendous potential return and the high level of accompanying risk. In this chapter, we examine the risk-return pattern for an array of cryptocurrencies, contrasting the pattern with those of conventional currency and equity investments. We find the measures of cryptocurrency returns and risk to be a very high multiple of those of conventional investments, and the pattern is determined to be robust relative to the time frame. 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Completed the Course Medical Mycology, the Centraalbureau voor Schimmelcultures (CBS), Fungal Biodiversity Centre, Netherlands (2006). International Union of Microbiological Societies (IUMS) Fellow, and International Emerging Infectious Diseases (IEID) Fellow, Centers for Diseases Control and Prevention (CDC), Atlanta, USA. Diploma of Dermatological Scientist, Japanese Society for Investigative Dermatology. Ph.D. of Juntendo University, Japan. Bachelor’s and Master’s degree, Medicine, West China University of Medical Sciences. Chair of Sichuan Medical Association Dermatology Committee. General Secretary of The 19th Annual Meeting of Chinese Society of Dermatology and the Asia Pacific Society for Medical Mycology (2013). In charge of the Annual Medical Mycology Course over 20-years authorized by National Continue Medical Education Committee of China. Member of the board of directors of the Asia-Pacific Society for Medical Mycology (APSMM). Associate editor of Mycopathologia. 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He is currently a rated researcher by the National Research Foundation of South Africa at category C2. He has published widely in the field of infectious diseases and has overseen several MSc’s and PhDs. His research activities mostly cover topics on infectious diseases from epidemiology to control. His particular interest lies in the study of intestinal protozoan parasites and opportunistic infections among HIV patients as well as the potential impact of childhood diarrhoea on growth and child development. He also conducts research on water-borne diseases and water quality and is involved in the evaluation of point-of-use water treatment technologies using silver and copper nanoparticles in collaboration with the University of Virginia, USA. 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His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. 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He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. 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Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}}]},{type:"book",id:"7123",title:"Current Topics in Neglected Tropical Diseases",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7123.jpg",slug:"current-topics-in-neglected-tropical-diseases",publishedDate:"December 4th 2019",editedByType:"Edited by",bookSignature:"Alfonso J. 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His research interests include computer graphics, computer vision, image processing, machine learning, pattern recognition, soft computing, data science, intelligent systems, information technology, and information systems. Prof. Sarfraz has been a keynote/invited speaker on various platforms around the globe. He has advised various students for their MSc and Ph.D. theses. He has published more than 400 publications as books, journal articles, and conference papers. He is a member of various professional societies and a chair and member of the International Advisory Committees and Organizing Committees of various international conferences. Prof. Sarfraz is also an editor-in-chief and editor of various international journals.",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"32650",title:"Prof.",name:"Lukas",middleName:"Willem",surname:"Snyman",slug:"lukas-snyman",fullName:"Lukas Snyman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/32650/images/4136_n.jpg",biography:"Lukas Willem Snyman received his basic education at primary and high schools in South Africa, Eastern Cape. He enrolled at today's Nelson Metropolitan University and graduated from this university with a BSc in Physics and Mathematics, B.Sc Honors in Physics, MSc in Semiconductor Physics, and a Ph.D. in Semiconductor Physics in 1987. After his studies, he chose an academic career and devoted his energy to the teaching of physics to first, second, and third-year students. After positions as a lecturer at the University of Port Elizabeth, he accepted a position as Associate Professor at the University of Pretoria, South Africa.\r\n\r\nIn 1992, he motivates the concept of 'television and computer-based education” as means to reach large student numbers with only the best of teaching expertise and publishes an article on the concept in the SA Journal of Higher Education of 1993 (and later in 2003). The University of Pretoria subsequently approved a series of test projects on the concept with outreach to Mamelodi and Eerste Rust in 1993. In 1994, the University established a 'Unit for Telematic Education ' as a support section for multiple faculties at the University of Pretoria. In subsequent years, the concept of 'telematic education” subsequently becomes well established in academic circles in South Africa, grew in popularity, and is adopted by many universities and colleges throughout South Africa as a medium of enhancing education and training, as a method to reaching out to far out communities, and as a means to enhance study from the home environment.\r\n\r\nProfessor Snyman in subsequent years pursued research in semiconductor physics, semiconductor devices, microelectronics, and optoelectronics.\r\n\r\nIn 2000 he joined the TUT as a full professor. Here served for a period as head of the Department of Electronic Engineering. Here he makes contributions to solar energy development, microwave and optoelectronic device development, silicon photonics, as well as contributions to new mobile telecommunication systems and network planning in SA.\r\n\r\nCurrently, he teaches electronics and telecommunications at the TUT to audiences ranging from first-year students to Ph.D. level.\r\n\r\nFor his research in the field of 'Silicon Photonics” since 1990, he has published (as author and co-author) about thirty internationally reviewed articles in scientific journals, contributed to more than forty international conferences, about 25 South African provisional patents (as inventor and co-inventor), 8 PCT international patent applications until now. Of these, two USA patents applications, two European Patents, two Korean patents, and ten SA patents have been granted. A further 4 USA patents, 5 European patents, 3 Korean patents, 3 Chinese patents, and 3 Japanese patents are currently under consideration.\r\n\r\nRecently he has also published an extensive scholarly chapter in an internet open access book on 'Integrating Microphotonic Systems and MOEMS into standard Silicon CMOS Integrated circuitry”.\r\n\r\nFurthermore, Professor Snyman recently steered a new initiative at the TUT by introducing a 'Laboratory for Innovative Electronic Systems ' at the Department of Electrical Engineering. The model of this laboratory or center is to primarily combine outputs as achieved by high-level research with lower-level system development and entrepreneurship in a technical university environment. Students are allocated to projects at different levels with PhDs and Master students allocated to the generation of new knowledge and new technologies, while students at the diploma and Baccalaureus level are allocated to electronic systems development with a direct and a near application for application in industry or the commercial and public sectors in South Africa.\r\n\r\nProfessor Snyman received the WIRSAM Award of 1983 and the WIRSAM Award in 1985 in South Africa for best research papers by a young scientist at two international conferences on electron microscopy in South Africa. He subsequently received the SA Microelectronics Award for the best dissertation emanating from studies executed at a South African university in the field of Physics and Microelectronics in South Africa in 1987. In October of 2011, Professor Snyman received the prestigious Institutional Award for 'Innovator of the Year” for 2010 at the Tshwane University of Technology, South Africa. This award was based on the number of patents recognized and granted by local and international institutions as well as for his contributions concerning innovation at the TUT.",institutionString:null,institution:{name:"University of South Africa",country:{name:"South Africa"}}},{id:"317279",title:"Mr.",name:"Ali",middleName:"Usama",surname:"Syed",slug:"ali-syed",fullName:"Ali Syed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/317279/images/16024_n.png",biography:"A creative, talented, and innovative young professional who is dedicated, well organized, and capable research fellow with two years of experience in graduate-level research, published in engineering journals and book, with related expertise in Bio-robotics, equally passionate about the aesthetics of the mechanical and electronic system, obtained expertise in the use of MS Office, MATLAB, SolidWorks, LabVIEW, Proteus, Fusion 360, having a grasp on python, C++ and assembly language, possess proven ability in acquiring research grants, previous appointments with social and educational societies with experience in administration, current affiliations with IEEE and Web of Science, a confident presenter at conferences and teacher in classrooms, able to explain complex information to audiences of all levels.",institutionString:null,institution:{name:"Air University",country:{name:"Pakistan"}}},{id:"75526",title:"Ph.D.",name:"Zihni Onur",middleName:null,surname:"Uygun",slug:"zihni-onur-uygun",fullName:"Zihni Onur Uygun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/75526/images/12_n.jpg",biography:"My undergraduate education and my Master of Science educations at Ege University and at Çanakkale Onsekiz Mart University have given me a firm foundation in Biochemistry, Analytical Chemistry, Biosensors, Bioelectronics, Physical Chemistry and Medicine. After obtaining my degree as a MSc in analytical chemistry, I started working as a research assistant in Ege University Medical Faculty in 2014. In parallel, I enrolled to the MSc program at the Department of Medical Biochemistry at Ege University to gain deeper knowledge on medical and biochemical sciences as well as clinical chemistry in 2014. In my PhD I deeply researched on biosensors and bioelectronics and finished in 2020. Now I have eleven SCI-Expanded Index published papers, 6 international book chapters, referee assignments for different SCIE journals, one international patent pending, several international awards, projects and bursaries. In parallel to my research assistant position at Ege University Medical Faculty, Department of Medical Biochemistry, in April 2016, I also founded a Start-Up Company (Denosens Biotechnology LTD) by the support of The Scientific and Technological Research Council of Turkey. Currently, I am also working as a CEO in Denosens Biotechnology. The main purposes of the company, which carries out R&D as a research center, are to develop new generation biosensors and sensors for both point-of-care diagnostics; such as glucose, lactate, cholesterol and cancer biomarker detections. My specific experimental and instrumental skills are Biochemistry, Biosensor, Analytical Chemistry, Electrochemistry, Mobile phone based point-of-care diagnostic device, POCTs and Patient interface designs, HPLC, Tandem Mass Spectrometry, Spectrophotometry, ELISA.",institutionString:null,institution:{name:"Ege University",country:{name:"Turkey"}}},{id:"267434",title:"Dr.",name:"Rohit",middleName:null,surname:"Raja",slug:"rohit-raja",fullName:"Rohit Raja",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/267434/images/system/267434.jpg",biography:"Dr. Rohit Raja received Ph.D. in Computer Science and Engineering from Dr. CVRAMAN University in 2016. His main research interest includes Face recognition and Identification, Digital Image Processing, Signal Processing, and Networking. Presently he is working as Associate Professor in IT Department, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur (CG), India. He has authored several Journal and Conference Papers. He has good Academics & Research experience in various areas of CSE and IT. He has filed and successfully published 27 Patents. He has received many time invitations to be a Guest at IEEE Conferences. He has published 100 research papers in various International/National Journals (including IEEE, Springer, etc.) and Proceedings of the reputed International/ National Conferences (including Springer and IEEE). He has been nominated to the board of editors/reviewers of many peer-reviewed and refereed Journals (including IEEE, Springer).",institutionString:"Guru Ghasidas Vishwavidyalaya",institution:{name:"Guru Ghasidas Vishwavidyalaya",country:{name:"India"}}},{id:"246502",title:"Dr.",name:"Jaya T.",middleName:"T",surname:"Varkey",slug:"jaya-t.-varkey",fullName:"Jaya T. Varkey",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246502/images/11160_n.jpg",biography:"Jaya T. Varkey, PhD, graduated with a degree in Chemistry from Cochin University of Science and Technology, Kerala, India. She obtained a PhD in Chemistry from the School of Chemical Sciences, Mahatma Gandhi University, Kerala, India, and completed a post-doctoral fellowship at the University of Minnesota, USA. She is a research guide at Mahatma Gandhi University and Associate Professor in Chemistry, St. Teresa’s College, Kochi, Kerala, India.\nDr. Varkey received a National Young Scientist award from the Indian Science Congress (1995), a UGC Research award (2016–2018), an Indian National Science Academy (INSA) Visiting Scientist award (2018–2019), and a Best Innovative Faculty award from the All India Association for Christian Higher Education (AIACHE) (2019). She Hashas received the Sr. Mary Cecil prize for best research paper three times. She was also awarded a start-up to develop a tea bag water filter. \nDr. Varkey has published two international books and twenty-seven international journal publications. She is an editorial board member for five international journals.",institutionString:"St. Teresa’s College",institution:null},{id:"250668",title:"Dr.",name:"Ali",middleName:null,surname:"Nabipour Chakoli",slug:"ali-nabipour-chakoli",fullName:"Ali Nabipour Chakoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/250668/images/system/250668.jpg",biography:"Academic Qualification:\r\n•\tPhD in Materials Physics and Chemistry, From: Sep. 2006, to: Sep. 2010, School of Materials Science and Engineering, Harbin Institute of Technology, Thesis: Structure and Shape Memory Effect of Functionalized MWCNTs/poly (L-lactide-co-ε-caprolactone) Nanocomposites. Supervisor: Prof. Wei Cai,\r\n•\tM.Sc in Applied Physics, From: 1996, to: 1998, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Determination of Boron in Micro alloy Steels with solid state nuclear track detectors by neutron induced auto radiography, Supervisors: Dr. M. Hosseini Ashrafi and Dr. A. Hosseini.\r\n•\tB.Sc. in Applied Physics, From: 1991, to: 1996, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Design of shielding for Am-Be neutron sources for In Vivo neutron activation analysis, Supervisor: Dr. M. Hosseini Ashrafi.\r\n\r\nResearch Experiences:\r\n1.\tNanomaterials, Carbon Nanotubes, Graphene: Synthesis, Functionalization and Characterization,\r\n2.\tMWCNTs/Polymer Composites: Fabrication and Characterization, \r\n3.\tShape Memory Polymers, Biodegradable Polymers, ORC, Collagen,\r\n4.\tMaterials Analysis and Characterizations: TEM, SEM, XPS, FT-IR, Raman, DSC, DMA, TGA, XRD, GPC, Fluoroscopy, \r\n5.\tInteraction of Radiation with Mater, Nuclear Safety and Security, NDT(RT),\r\n6.\tRadiation Detectors, Calibration (SSDL),\r\n7.\tCompleted IAEA e-learning Courses:\r\nNuclear Security (15 Modules),\r\nNuclear Safety:\r\nTSA 2: Regulatory Protection in Occupational Exposure,\r\nTips & Tricks: Radiation Protection in Radiography,\r\nSafety and Quality in Radiotherapy,\r\nCourse on Sealed Radioactive Sources,\r\nCourse on Fundamentals of Environmental Remediation,\r\nCourse on Planning for Environmental Remediation,\r\nKnowledge Management Orientation Course,\r\nFood Irradiation - Technology, Applications and Good Practices,\r\nEmployment:\r\nFrom 2010 to now: Academic staff, Nuclear Science and Technology Research Institute, Kargar Shomali, Tehran, Iran, P.O. Box: 14395-836.\r\nFrom 1997 to 2006: Expert of Materials Analysis and Characterization. Research Center of Agriculture and Medicine. Rajaeeshahr, Karaj, Iran, P. O. Box: 31585-498.",institutionString:"Atomic Energy Organization of Iran",institution:{name:"Atomic Energy Organization of Iran",country:{name:"Iran"}}},{id:"248279",title:"Dr.",name:"Monika",middleName:"Elzbieta",surname:"Machoy",slug:"monika-machoy",fullName:"Monika Machoy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248279/images/system/248279.jpeg",biography:"Monika Elżbieta Machoy, MD, graduated with distinction from the Faculty of Medicine and Dentistry at the Pomeranian Medical University in 2009, defended her PhD thesis with summa cum laude in 2016 and is currently employed as a researcher at the Department of Orthodontics of the Pomeranian Medical University. She expanded her professional knowledge during a one-year scholarship program at the Ernst Moritz Arndt University in Greifswald, Germany and during a three-year internship at the Technical University in Dresden, Germany. She has been a speaker at numerous orthodontic conferences, among others, American Association of Orthodontics, European Orthodontic Symposium and numerous conferences of the Polish Orthodontic Society. She conducts research focusing on the effect of orthodontic treatment on dental and periodontal tissues and the causes of pain in orthodontic patients.",institutionString:"Pomeranian Medical University",institution:{name:"Pomeranian Medical University",country:{name:"Poland"}}},{id:"252743",title:"Prof.",name:"Aswini",middleName:"Kumar",surname:"Kar",slug:"aswini-kar",fullName:"Aswini Kar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252743/images/10381_n.jpg",biography:"uploaded in cv",institutionString:null,institution:{name:"KIIT University",country:{name:"India"}}},{id:"204256",title:"Dr.",name:"Anil",middleName:"Kumar",surname:"Kumar Sahu",slug:"anil-kumar-sahu",fullName:"Anil Kumar Sahu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204256/images/14201_n.jpg",biography:"I have nearly 11 years of research and teaching experience. I have done my master degree from University Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur, Chhattisgarh India. I have published 16 review and research articles in international and national journals and published 4 chapters in IntechOpen, the world’s leading publisher of Open access books. I have presented many papers at national and international conferences. I have received research award from Indian Drug Manufacturers Association in year 2015. My research interest extends from novel lymphatic drug delivery systems, oral delivery system for herbal bioactive to formulation optimization.",institutionString:null,institution:{name:"Chhattisgarh Swami Vivekanand Technical University",country:{name:"India"}}},{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",biography:"An assistant professor at Department of Biomedical Computer Systems, at Institute of Computer Science, Silesian University in Katowice. Scientific interests: computer analysis and processing of images, biomedical images, databases and programming languages. He is an author and co-author of scientific publications covering analysis and processing of biomedical images and development of database systems.",institutionString:"University of Silesia",institution:{name:"University of Silesia",country:{name:"Poland"}}},{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",biography:"Dr. Hadi Mohammadi is a biomedical engineer with hands-on experience in the design and development of many engineering structures and medical devices through various projects that he has been involved in over the past twenty years. Dr. Mohammadi received his BSc. and MSc. degrees in Mechanical Engineering from Sharif University of Technology, Tehran, Iran, and his PhD. degree in Biomedical Engineering (biomaterials) from the University of Western Ontario. He was a postdoctoral trainee for almost four years at University of Calgary and Harvard Medical School. He is an industry innovator having created the technology to produce lifelike synthetic platforms that can be used for the simulation of almost all cardiovascular reconstructive surgeries. He’s been heavily involved in the design and development of cardiovascular devices and technology for the past 10 years. He is currently an Assistant Professor with the University of British Colombia, Canada.",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",country:{name:"Canada"}}},{id:"254463",title:"Prof.",name:"Haisheng",middleName:null,surname:"Yang",slug:"haisheng-yang",fullName:"Haisheng Yang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/254463/images/system/254463.jpeg",biography:"Haisheng Yang, Ph.D., Professor and Director of the Department of Biomedical Engineering, College of Life Science and Bioengineering, Beijing University of Technology. He received his Ph.D. degree in Mechanics/Biomechanics from Harbin Institute of Technology (jointly with University of California, Berkeley). Afterwards, he worked as a Postdoctoral Research Associate in the Purdue Musculoskeletal Biology and Mechanics Lab at the Department of Basic Medical Sciences, Purdue University, USA. He also conducted research in the Research Centre of Shriners Hospitals for Children-Canada at McGill University, Canada. Dr. Yang has over 10 years research experience in orthopaedic biomechanics and mechanobiology of bone adaptation and regeneration. He earned an award from Beijing Overseas Talents Aggregation program in 2017 and serves as Beijing Distinguished Professor.",institutionString:null,institution:{name:"Beijing University of Technology",country:{name:"China"}}},{id:"89721",title:"Dr.",name:"Mehmet",middleName:"Cuneyt",surname:"Ozmen",slug:"mehmet-ozmen",fullName:"Mehmet Ozmen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/89721/images/7289_n.jpg",biography:null,institutionString:null,institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"265335",title:"Mr.",name:"Stefan",middleName:"Radnev",surname:"Stefanov",slug:"stefan-stefanov",fullName:"Stefan Stefanov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/265335/images/7562_n.jpg",biography:null,institutionString:null,institution:{name:"Medical University Plovdiv",country:{name:"Bulgaria"}}},{id:"242893",title:"Ph.D. Student",name:"Joaquim",middleName:null,surname:"De Moura",slug:"joaquim-de-moura",fullName:"Joaquim De Moura",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/242893/images/7133_n.jpg",biography:"Joaquim de Moura received his degree in Computer Engineering in 2014 from the University of A Coruña (Spain). In 2016, he received his M.Sc degree in Computer Engineering from the same university. He is currently pursuing his Ph.D degree in Computer Science in a collaborative project between ophthalmology centers in Galicia and the University of A Coruña. His research interests include computer vision, machine learning algorithms and analysis and medical imaging processing of various kinds.",institutionString:null,institution:{name:"University of A Coruña",country:{name:"Spain"}}},{id:"294334",title:"B.Sc.",name:"Marc",middleName:null,surname:"Bruggeman",slug:"marc-bruggeman",fullName:"Marc Bruggeman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/294334/images/8242_n.jpg",biography:"Chemical engineer graduate, with a passion for material science and specific interest in polymers - their near infinite applications intrigue me. \n\nI plan to continue my scientific career in the field of polymeric biomaterials as I am fascinated by intelligent, bioactive and biomimetic materials for use in both consumer and medical applications.",institutionString:null,institution:null},{id:"255757",title:"Dr.",name:"Igor",middleName:"Victorovich",surname:"Lakhno",slug:"igor-lakhno",fullName:"Igor Lakhno",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255757/images/system/255757.jpg",biography:"Igor Victorovich Lakhno was born in 1971 in Kharkiv (Ukraine). \nMD – 1994, Kharkiv National Medical Univesity.\nOb&Gyn; – 1997, master courses in Kharkiv Medical Academy of Postgraduate Education.\nPh.D. – 1999, Kharkiv National Medical Univesity.\nDSC – 2019, PL Shupik National Academy of Postgraduate Education \nProfessor – 2021, Department of Obstetrics and Gynecology of VN Karazin Kharkiv National University\nHead of Department – 2021, Department of Perinatology, Obstetrics and gynecology of Kharkiv Medical Academy of Postgraduate Education\nIgor Lakhno has been graduated from international training courses on reproductive medicine and family planning held at Debrecen University (Hungary) in 1997. Since 1998 Lakhno Igor has worked as an associate professor in the department of obstetrics and gynecology of VN Karazin National University and an associate professor of the perinatology, obstetrics, and gynecology department of Kharkiv Medical Academy of Postgraduate Education. Since June 2019 he’s been a professor in the department of obstetrics and gynecology of VN Karazin National University and a professor of the perinatology, obstetrics, and gynecology department. He’s affiliated with Kharkiv Medical Academy of Postgraduate Education as a Head of Department from November 2021. Igor Lakhno has participated in several international projects on fetal non-invasive electrocardiography (with Dr. J. A. Behar (Technion), Prof. D. Hoyer (Jena University), and José Alejandro Díaz Méndez (National Institute of Astrophysics, Optics, and Electronics, Mexico). He’s an author of about 200 printed works and there are 31 of them in Scopus or Web of Science databases. Igor Lakhno is a member of the Editorial Board of Reproductive Health of Woman, Emergency Medicine, and Technology Transfer Innovative Solutions in Medicine (Estonia). He is a medical Editor of “Z turbotoyu pro zhinku”. Igor Lakhno is a reviewer of the Journal of Obstetrics and Gynaecology (Taylor and Francis), British Journal of Obstetrics and Gynecology (Wiley), Informatics in Medicine Unlocked (Elsevier), The Journal of Obstetrics and Gynecology Research (Wiley), Endocrine, Metabolic & Immune Disorders-Drug Targets (Bentham Open), The Open Biomedical Engineering Journal (Bentham Open), etc. He’s defended a dissertation for a DSc degree “Pre-eclampsia: prediction, prevention, and treatment”. Three years ago Igor Lakhno has participated in a training course on innovative technologies in medical education at Lublin Medical University (Poland). Lakhno Igor has participated as a speaker in several international conferences and congresses (International Conference on Biological Oscillations April 10th-14th 2016, Lancaster, UK, The 9th conference of the European Study Group on Cardiovascular Oscillations). His main scientific interests: are obstetrics, women’s health, fetal medicine, and cardiovascular medicine. \nIgor Lakhno is a consultant at Kharkiv municipal perinatal center. He’s graduated from training courses on endoscopy in gynecology. He has 28 years of practical experience in the field.",institutionString:null,institution:null},{id:"244950",title:"Dr.",name:"Salvatore",middleName:null,surname:"Di Lauro",slug:"salvatore-di-lauro",fullName:"Salvatore Di Lauro",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0030O00002bSF1HQAW/ProfilePicture%202021-12-20%2014%3A54%3A14.482",biography:"Name:\n\tSALVATORE DI LAURO\nAddress:\n\tHospital Clínico Universitario Valladolid\nAvda Ramón y Cajal 3\n47005, Valladolid\nSpain\nPhone number: \nFax\nE-mail:\n\t+34 983420000 ext 292\n+34 983420084\nsadilauro@live.it\nDate and place of Birth:\nID Number\nMedical Licence \nLanguages\t09-05-1985. Villaricca (Italy)\n\nY1281863H\n474707061\nItalian (native language)\nSpanish (read, written, spoken)\nEnglish (read, written, spoken)\nPortuguese (read, spoken)\nFrench (read)\n\t\t\nCurrent position (title and company)\tDate (Year)\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. Private practise.\t2017-today\n\n2019-today\n\t\n\t\nEducation (High school, university and postgraduate training > 3 months)\tDate (Year)\nDegree in Medicine and Surgery. University of Neaples 'Federico II”\nResident in Opthalmology. Hospital Clinico Universitario Valladolid\nMaster in Vitreo-Retina. IOBA. University of Valladolid\nFellow of the European Board of Ophthalmology. Paris\nMaster in Research in Ophthalmology. University of Valladolid\t2003-2009\n2012-2016\n2016-2017\n2016\n2012-2013\n\t\nEmployments (company and positions)\tDate (Year)\nResident in Ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl.\nFellow in Vitreo-Retina. IOBA. University of Valladolid\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. \n\t2012-2016\n2016-2017\n2017-today\n\n2019-Today\n\n\n\t\nClinical Research Experience (tasks and role)\tDate (Year)\nAssociated investigator\n\n' FIS PI20/00740: DESARROLLO DE UNA CALCULADORA DE RIESGO DE\nAPARICION DE RETINOPATIA DIABETICA BASADA EN TECNICAS DE IMAGEN MULTIMODAL EN PACIENTES DIABETICOS TIPO 1. Grant by: Ministerio de Ciencia e Innovacion \n\n' (BIO/VA23/14) Estudio clínico multicéntrico y prospectivo para validar dos\nbiomarcadores ubicados en los genes p53 y MDM2 en la predicción de los resultados funcionales de la cirugía del desprendimiento de retina regmatógeno. Grant by: Gerencia Regional de Salud de la Junta de Castilla y León.\n' Estudio multicéntrico, aleatorizado, con enmascaramiento doble, en 2 grupos\nparalelos y de 52 semanas de duración para comparar la eficacia, seguridad e inmunogenicidad de SOK583A1 respecto a Eylea® en pacientes con degeneración macular neovascular asociada a la edad' (CSOK583A12301; N.EUDRA: 2019-004838-41; FASE III). Grant by Hexal AG\n\n' Estudio de fase III, aleatorizado, doble ciego, con grupos paralelos, multicéntrico para comparar la eficacia y la seguridad de QL1205 frente a Lucentis® en pacientes con degeneración macular neovascular asociada a la edad. (EUDRACT: 2018-004486-13). Grant by Qilu Pharmaceutical Co\n\n' Estudio NEUTON: Ensayo clinico en fase IV para evaluar la eficacia de aflibercept en pacientes Naive con Edema MacUlar secundario a Oclusion de Vena CenTral de la Retina (OVCR) en regimen de tratamientO iNdividualizado Treat and Extend (TAE)”, (2014-000975-21). Grant by Fundacion Retinaplus\n\n' Evaluación de la seguridad y bioactividad de anillos de tensión capsular en conejo. Proyecto Procusens. Grant by AJL, S.A.\n\n'Estudio epidemiológico, prospectivo, multicéntrico y abierto\\npara valorar la frecuencia de la conjuntivitis adenovírica diagnosticada mediante el test AdenoPlus®\\nTest en pacientes enfermos de conjuntivitis aguda”\\n. National, multicenter study. Grant by: NICOX.\n\nEuropean multicentric trial: 'Evaluation of clinical outcomes following the use of Systane Hydration in patients with dry eye”. Study Phase 4. Grant by: Alcon Labs'\n\nVLPs Injection and Activation in a Rabbit Model of Uveal Melanoma. Grant by Aura Bioscience\n\nUpdating and characterization of a rabbit model of uveal melanoma. Grant by Aura Bioscience\n\nEnsayo clínico en fase IV para evaluar las variantes genéticas de la vía del VEGF como biomarcadores de eficacia del tratamiento con aflibercept en pacientes con degeneración macular asociada a la edad (DMAE) neovascular. Estudio BIOIMAGE. IMO-AFLI-2013-01\n\nEstudio In-Eye:Ensayo clínico en fase IV, abierto, aleatorizado, de 2 brazos,\nmulticçentrico y de 12 meses de duración, para evaluar la eficacia y seguridad de un régimen de PRN flexible individualizado de 'esperar y extender' versus un régimen PRN según criterios de estabilización mediante evaluaciones mensuales de inyecciones intravítreas de ranibizumab 0,5 mg en pacientes naive con neovascularización coriodea secunaria a la degeneración macular relacionada con la edad. CP: CRFB002AES03T\n\nTREND: Estudio Fase IIIb multicéntrico, randomizado, de 12 meses de\nseguimiento con evaluador de la agudeza visual enmascarado, para evaluar la eficacia y la seguridad de ranibizumab 0.5mg en un régimen de tratar y extender comparado con un régimen mensual, en pacientes con degeneración macular neovascular asociada a la edad. CP: CRFB002A2411 Código Eudra CT:\n2013-002626-23\n\n\n\nPublications\t\n\n2021\n\n\n\n\n2015\n\n\n\n\n2021\n\n\n\n\n\n2021\n\n\n\n\n2015\n\n\n\n\n2015\n\n\n2014\n\n\n\n\n2015-16\n\n\n\n2015\n\n\n2014\n\n\n2014\n\n\n\n\n2014\n\n\n\n\n\n\n\n2014\n\nJose Carlos Pastor; Jimena Rojas; Salvador Pastor-Idoate; Salvatore Di Lauro; Lucia Gonzalez-Buendia; Santiago Delgado-Tirado. Proliferative vitreoretinopathy: A new concept of disease pathogenesis and practical\nconsequences. Progress in Retinal and Eye Research. 51, pp. 125 - 155. 03/2016. DOI: 10.1016/j.preteyeres.2015.07.005\n\n\nLabrador-Velandia S; Alonso-Alonso ML; Di Lauro S; García-Gutierrez MT; Srivastava GK; Pastor JC; Fernandez-Bueno I. Mesenchymal stem cells provide paracrine neuroprotective resources that delay degeneration of co-cultured organotypic neuroretinal cultures.Experimental Eye Research. 185, 17/05/2019. DOI: 10.1016/j.exer.2019.05.011\n\nSalvatore Di Lauro; Maria Teresa Garcia Gutierrez; Ivan Fernandez Bueno. Quantification of pigment epithelium-derived factor (PEDF) in an ex vivo coculture of retinal pigment epithelium cells and neuroretina.\nJournal of Allbiosolution. 2019. ISSN 2605-3535\n\nSonia Labrador Velandia; Salvatore Di Lauro; Alonso-Alonso ML; Tabera Bartolomé S; Srivastava GK; Pastor JC; Fernandez-Bueno I. Biocompatibility of intravitreal injection of human mesenchymal stem cells in immunocompetent rabbits. Graefe's archive for clinical and experimental ophthalmology. 256 - 1, pp. 125 - 134. 01/2018. DOI: 10.1007/s00417-017-3842-3\n\n\nSalvatore Di Lauro, David Rodriguez-Crespo, Manuel J Gayoso, Maria T Garcia-Gutierrez, J Carlos Pastor, Girish K Srivastava, Ivan Fernandez-Bueno. A novel coculture model of porcine central neuroretina explants and retinal pigment epithelium cells. Molecular Vision. 2016 - 22, pp. 243 - 253. 01/2016.\n\nSalvatore Di Lauro. Classifications for Proliferative Vitreoretinopathy ({PVR}): An Analysis of Their Use in Publications over the Last 15 Years. Journal of Ophthalmology. 2016, pp. 1 - 6. 01/2016. DOI: 10.1155/2016/7807596\n\nSalvatore Di Lauro; Rosa Maria Coco; Rosa Maria Sanabria; Enrique Rodriguez de la Rua; Jose Carlos Pastor. Loss of Visual Acuity after Successful Surgery for Macula-On Rhegmatogenous Retinal Detachment in a Prospective Multicentre Study. Journal of Ophthalmology. 2015:821864, 2015. DOI: 10.1155/2015/821864\n\nIvan Fernandez-Bueno; Salvatore Di Lauro; Ivan Alvarez; Jose Carlos Lopez; Maria Teresa Garcia-Gutierrez; Itziar Fernandez; Eva Larra; Jose Carlos Pastor. Safety and Biocompatibility of a New High-Density Polyethylene-Based\nSpherical Integrated Porous Orbital Implant: An Experimental Study in Rabbits. Journal of Ophthalmology. 2015:904096, 2015. DOI: 10.1155/2015/904096\n\nPastor JC; Pastor-Idoate S; Rodríguez-Hernandez I; Rojas J; Fernandez I; Gonzalez-Buendia L; Di Lauro S; Gonzalez-Sarmiento R. Genetics of PVR and RD. Ophthalmologica. 232 - Suppl 1, pp. 28 - 29. 2014\n\nRodriguez-Crespo D; Di Lauro S; Singh AK; Garcia-Gutierrez MT; Garrosa M; Pastor JC; Fernandez-Bueno I; Srivastava GK. Triple-layered mixed co-culture model of RPE cells with neuroretina for evaluating the neuroprotective effects of adipose-MSCs. Cell Tissue Res. 358 - 3, pp. 705 - 716. 2014.\nDOI: 10.1007/s00441-014-1987-5\n\nCarlo De Werra; Salvatore Condurro; Salvatore Tramontano; Mario Perone; Ivana Donzelli; Salvatore Di Lauro; Massimo Di Giuseppe; Rosa Di Micco; Annalisa Pascariello; Antonio Pastore; Giorgio Diamantis; Giuseppe Galloro. Hydatid disease of the liver: thirty years of surgical experience.Chirurgia italiana. 59 - 5, pp. 611 - 636.\n(Italia): 2007. ISSN 0009-4773\n\nChapters in books\n\t\n' Salvador Pastor Idoate; Salvatore Di Lauro; Jose Carlos Pastor Jimeno. PVR: Pathogenesis, Histopathology and Classification. Proliferative Vitreoretinopathy with Small Gauge Vitrectomy. Springer, 2018. ISBN 978-3-319-78445-8\nDOI: 10.1007/978-3-319-78446-5_2. \n\n' Salvatore Di Lauro; Maria Isabel Lopez Galvez. Quistes vítreos en una mujer joven. Problemas diagnósticos en patología retinocoroidea. Sociedad Española de Retina-Vitreo. 2018.\n\n' Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor Jimeno. iOCT in PVR management. OCT Applications in Opthalmology. pp. 1 - 8. INTECH, 2018. DOI: 10.5772/intechopen.78774.\n\n' Rosa Coco Martin; Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor. amponadores, manipuladores y tinciones en la cirugía del traumatismo ocular.Trauma Ocular. Ponencia de la SEO 2018..\n\n' LOPEZ GALVEZ; DI LAURO; CRESPO. OCT angiografia y complicaciones retinianas de la diabetes. PONENCIA SEO 2021, CAPITULO 20. (España): 2021.\n\n' Múltiples desprendimientos neurosensoriales bilaterales en paciente joven. Enfermedades Degenerativas De Retina Y Coroides. SERV 04/2016. \n' González-Buendía L; Di Lauro S; Pastor-Idoate S; Pastor Jimeno JC. Vitreorretinopatía proliferante (VRP) e inflamación: LA INFLAMACIÓN in «INMUNOMODULADORES Y ANTIINFLAMATORIOS: MÁS ALLÁ DE LOS CORTICOIDES. 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