\r\n\tFurthermore, during the preparation of high-quality dairy products, several physical, chemical, enzymatic, and microbial transformations take place. We will consciously focus on this interaction of different constituents of milk under different processing conditions for the development of the products.
",isbn:"978-1-83768-093-1",printIsbn:"978-1-83768-092-4",pdfIsbn:"978-1-83768-094-8",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,isNomenclature:!1,hash:"420e687768b56ca7b3238d77f63f1302",bookSignature:"Dr. Neelam Upadhyay",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/12173.jpg",keywords:"Protein, Fat, Lactose, Carbohydrates, Milk Processing, Milk Products, Milk Constituents, Acid Coagulated, Enzyme Treated, Heat Treated, Dairy Products, Protocols of Manufacturing",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"May 18th 2022",dateEndSecondStepPublish:"June 15th 2022",dateEndThirdStepPublish:"August 14th 2022",dateEndFourthStepPublish:"November 2nd 2022",dateEndFifthStepPublish:"January 1st 2023",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"21 days",secondStepPassed:!1,areRegistrationsClosed:!1,currentStepOfPublishingProcess:2,editedByType:null,kuFlag:!1,biosketch:"Dr. Upadhyay has received many awards most notable being the Young Woman Scientist Award 2020 from the Agro-Environmental Development Society and the Best Poster Award 2021 from the National Conference on Moringa Food Conclave 2021. She is a dedicated researcher in food and dairy processing and has published many research articles and papers in both national and international journals and publications.",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"269538",title:"Dr.",name:"Neelam",middleName:null,surname:"Upadhyay",slug:"neelam-upadhyay",fullName:"Neelam Upadhyay",profilePictureURL:"https://mts.intechopen.com/storage/users/269538/images/system/269538.jpg",biography:"BRIEF BIODATA\n1.\tName in full: Neelam Upadhyay \n2.\tDate & Place of Birth: 29th December, 1987 at Delhi\n3.\tField of specialization: Food Technology\n4.\tPresent Position/ Designation: Scientist- Senior Scale\n5.\tAddress:\t(a)\tOfficial:\tTel. No.:0184-2259258\n\t\t\t\tE-mail: \ticar.neelam@gmail.com; neelam.upadhyay@icar.gov.in \n\t\t\t\tAddress: \tLaboratory No. 146, Dairy Technology Division, ICAR- \n\t\t\t\t\t\tNational Dairy Research Institute, Karnal \n\t\t\t(b)\tResidential: Tel. No.: +91-9255772587\n\tAddress (Permanent): 41-D, MIG DDA Flats, Shivam Enclave, Delhi-110032\n6.\t(a) Academic career and (b) professional attainments\n(a) Examination\tClass/ Percentage\tYear of Passing\tSubjects Taken\tName of University / Board\nXth \t1st/83\n(415/500)\t2003\tMathematics, Social Science, Science, English, Hindi\tK.V., Mumbai (CBSE)\nXIIth\t1st/78.2 \n(391/500)\t2005\tPhysics, Mathematics, Chemistry, Biology, English\tK.V., Delhi (CBSE)\nB.A.Sc. (Hons.)\t1st/83.43 (2044/2450)\n(3rd position)\t2008\tFood Technology\tSRCASW, University of Delhi, Delhi\nM.Sc.\t1st/8.62\n(1st position)\t2010\tFood Science & Technology\tCCS Har. Agri. Uni., Hisar, Haryana\nTitle of Research:\tDevelopment of flavoured whey-soya milk beverage\nMajor Advisor:\tDr. R. S. Dabur (Professor and Head)\nPh.D.\t1st/8.0\n(1st position)\t2014\tDairy Chemistry\tNational Dairy Research Institute, Karnal, Haryana\nTitle of Research: \tDetection of vegetable oil and animal body fat adulteration in ghee using solvent fractionation technique\nMajor Advisor:\tDr. Darshan Lal (Principal Scientist and Ex-Head)\nDistinctions during Academics\nDegree\tDistinctions\nBachelor of Applied Science (Hons.)\ti.\tY.K. Kapoor Memorial Scholarship 2006 by All India Food Processor’s Association \nii.\t3rd position in university\niii.\tReceived highest attendance award\niv.\tReceived trophy for ‘Most Disciplined Student’ for the graduation period 2005-2008\nv.\tCertificate of Honor from Honb’le Mr. Justice K.G. Balakrishnan, Chief Justice of India\nMaster of Science\ti.\t1st position in discipline and 2nd position in college\nii.\tReceived recognition for academic excellence from Jawaharlal Nehru Memorial Fund; \niii.\tQualified GATE\niv.\t2nd in inter-college yoga competition\nv.\tParticipated in various events of All India Youth Festival organized at UAS, Bangalore.\nDoctor of Philosophy\ti.\tReceived Merit Certificate for Academic Excellence in PhD course work\nii.\tReceived Certificate of Appreciation for outstanding work in the field of Dairy Processing during PhD\niii.\tQualified ICAR’s National Eligibility Test in 2010; Qualified the ICAR’s All India Examination, ICAR-SRF (PGS_-2011-2012 for award of ICAR-SRF (PGS) with 2nd rank (both in first attempt) \niv.\tQualified Agricultural Research Service Examination-2013 conducted by Agricultural Scientist Recruitment Board against the single vacancy (for UR) in the discipline of Food Technology\nv.\tStage Management Secretary of student’s council 2010-11\nvi.\tLiterary secretary of Student’s Council 2011-12\nvii.\tCompleted certificate e-course on “Publishing a Journal Manuscript - the Groundwork” directed by Springer in 2013\nviii.\tHave successfully completed certificate e-course – “Peer Review Academy” directed by Springer in 2013\nix.\tReceived a certificate on accomplishment IRIS 4-2 Information Literacy Plagiarism Quiz (on-line) in 2013 developed by Distance Learning Council of Washington, USA \n (b) Position Held\tInstitution \tPeriod of Appointment\tNature of Appointment\nScientist (Food Technology)\tICAR- National Academy of Agricultural Research Management, Hyderabad\t3 months\n(1st January, 2015 till 31st March, 2015)\tPermanent\n(Received ‘A’ grade for FOCARS)\nScientist \n(Food Technology)\tICAR- National Dairy Research Institute, Karnal\t10th March, 2015 till 31st December, 2018\n(after availing 10 days of transfer period)\tPermanent\nScientist-Senior Scale\n(Food Technology)\tICAR- National Dairy Research Institute, Karnal\t1st January, 2019 till date\tPermanent\n\n7. Special attainments in Research\n(https://scholar.google.co.in/citations?hl=en&user=PRz0Tz4AAAAJ&view_op=list_works&sortby=pubdate)\nPublications\tNumbers\tRemarks \nResearch Articles\t35\n(24 Intl, 9 National, 2 others)\tTotal Impact: 72.302\n\nBook Chapters\t7\t5 APA/CRC Press; 1 InTech Open; \n1 National\nReview Articles\t2\tTotal Impact:8.327\nTechnical Articles\t7\tCompendium of trainings, seminars, etc\nInstitute publication\t1\t\nPopular Article\t12\t6 in English; 5 in hindi\nCitations \t1066\t(as per googlescholar)\nH-index/ i10-index\t15/ 17\t\n.\n.\nJournal\tNumber of publications\tImpact factor\nResearch Articles\t35\t72.302\nInternational\t24 (15 as either corresponding or first author)\t72.302\nNational\t9 (3 as first or corresponding author)\tNAAS score\nOthers\t2\t\nReview article (International)\t2\t8.327\nInternational\t2\t8.327\n.\n \n\n\n\nRESEARCH ARTICLES\nInternational Journals \n1.\tTiwari, S., Upadhyay, N.*, Singh, A. K. (2022). Stability assessment of emulsion of carotenoids extracted from carrot bio-waste in flaxseed oil and its application in food model system. Food Bioscience, 47, 101631. https://doi.org/10.1016/j.fbio.2022.101631.\n2.\tPatil, A. T., Meena, G. S., Upadhyay, N., Khetra, Y., Singh, A. K., & Borad, S. G. (2021). Buffalo milk protein concentrate 60: Effect of skim milk heat treatment on its reconstitutability and functionality. Food Science & Technology – Lebensmittel -Wissenschaft & Tech, 148, 111638. \n3.\tUttamrao, H. J., Meena, G. S., Khetra, Y., Upadhyay, N., Singh, A. K., Arora, S., & Borad, S. G. (2022). Homogenization and sodium hydrogen phosphate induced effect on physical and rheological properties of ultrafilterd concentrated milk. Journal of Food Science and Technology, 59(3), 956-967. \n4.\tTiwari, S., Upadhyay, N.*, Malhotra, R. (2021). Three way ANOVA for emulsion of carotenoids extracted in flaxseed oil from carrot bio-waste. Waste Management, 121, 67-76. \n5.\tRanvir, S., Sharma, R., Gandhi, K., Upadhyay, N., Mann, B. (2020). Assessment of proteolysis in ultra-high temperature milk using attenuated total reflectance–Fourier transform infrared spectroscopy. International Journal of Dairy Technology. 73(2): 366-375. doi: 10.1111/1471-0307.12683. \n6.\tPonbhagavathi, T.R., Singh, A.K., Raju, P.N., Upadhyay, N. (2020). High performance liquid chromatographic (HPLC) determination of available lysine in milk protein-maize composite extrudates and its stability during storage. Journal of the Indian Chemical Society, 97(11a), 2344-2350\n7.\tTiwari, S., Upadhyay, N.*, Singh, A. K., Meena, G. S., & Arora, S. (2019). Organic solvent-free extraction of carotenoids from carrot bio-waste and its physico-chemical properties. Journal of Food Science and Technology, 1-10. 10.1007/s13197-019-03920-5\n8.\tBaria, B., Upadhyay, N.*, Singh, A. K., & Malhotra, R. K. (2019). Optimization of ‘green’extraction of carotenoids from mango pulp using split plot design and its characterization. Food Science & Technology – Lebensmittel -Wissenschaft & Tech, 104, 186-194. \n9.\tPatil, A. T., Meena, G. S., Upadhyay, N., Khetra, Y., Borad, S. G., & Singh, A. K. (2019). Effect of change in pH, heat treatment and diafiltration on properties of medium protein buffalo milk protein concentrate. Journal of Food Science and Technology, 56(3), 1462-1472. \n10.\tUttamrao, H. J., Meena, G. S., Borad, S. G., Punjaram, S. A., Khetra, Y., Upadhyay, N., & Singh, A. K. (2019). Effect of disodium phosphate and homogenization on physico-chemical and rheological properties of buffalo skim milk based ultrafiltered retentate. Journal of food science and technology, 56(5), 2426-2435. \n11.\tMeena, G.S., Dewan, A., Upadhyay, N., Barapatre, R., Kumar, N., Singh, A.K., & Rana, J.S. (2019). Fuzzy Analysis of Sensory Attributes of Gluten Free Pasta Prepared From Brown Rice, Amaranth, Flaxseed Flours and Whey Protein Concentrates. Journal of Food Science and Nutrition Research, 2(1), 022-037. DOI: 10.26502/jfsnr.2642-1100006\n12.\tPatil, A. T., Meena, G. S., Upadhyay, N.*, Khetra, Y., Borad, S., & Singh, A. K. (2018). Production and characterization of milk protein concentrates 60 (MPC60) from buffalo milk. Food Science & Technology – Lebensmittel -Wissenschaft & Tech, 91, 368-374. https://doi.org/10.1016/j.lwt.2018.01.028 \n13.\tUpadhyay, N.*, Jaiswal, P., & Jha, S. N. (2018). Application of attenuated total reflectance Fourier Transform Infrared spectroscopy (ATR–FTIR) in MIR range coupled with chemometrics for detection of pig body fat in pure ghee (heat clarified milk fat). Journal of Molecular Structure, 1153, 275-281. \n14.\tUpadhyay, N.*, Kumar A., Goyal A. and Lal, D. (2017). Complete liquification time test coupled with solvent fractionation technique to detect adulteration of foreign fats in ghee (heat-clarified milk fat). International Journal of Dairy Technology. 70(1): 110-118. doi: 10.1111/1471-0307.12323. \n15.\tUpadhyay, N.*, Goyal A., Kumar A. and Lal, D. (2017). Detection of adulteration of caprine body fat and mixture of caprine body fat and groundnut oil in bovine and buffalo ghee using Differential Scanning Calorimetry. International Journal of Dairy Technology. 70(2): 297-303. May 2017.doi:10.1111/1471-0307.12336. \n16.\tKumar, A., Upadhyay, N.*, Ghai, D.L., Kumar, A. Gandhi, K. and Sharma, V. (2016). Effect of preparation and storage of khoa on physico-chemical properties of milk fat. International Journal of Dairy Technology. 69(2): 294-300. doi: 10.1111/1471-0307.12266. \n17.\tUpadhyay, N.*, Jaiswal, P. & Jha, S.N. (2016). Detection of goat body fat adulteration in pure ghee using ATR-FTIR spectroscopy coupled with chemometric strategy. Journal of Food Science and Technology. 53 (10): 3752-3760. doi:10.1007/s13197-016-2353-2 ISSN 0022-1155\n18.\tRathi, M., Upadhyay, N.*, Dabur, R.S. and Goyal A. (2015). Formulation and physic-chemical analysis of whey –soymilk dahi. Journal of Food Science and Technology. 52(2): 968-975. doi 10.1007/s13197-013-1074-z. ISSN: 0022-1155. \n19.\tKanthale, P., Kumar, A. Upadhyay, N.*, Lal, D., Rathod G. and Sharma, V. (2015). Qualitative test for the detection of extraneous Thiocyanate in Milk. Journal of Food Science and Technology. 52(3): 1698-1704. DOI: 10.1007/s13197-013-1174-9. ISSN: 0022-1155.\n20.\tGoyal, A., Sharma, V., Upadhyay, N., Singh, A.K., Arora, S. and Ghai, D.L. (2015). Development of stable flaxseed oil emulsions as a potential delivery system of ω-3 fatty acids. Journal of Food Science and Technology. 52(7):4256-4265. \n21.\tUpadhyay, N.*, Kumar, A., Rathod, G., Goyal, A. and Lal, D. (2015). Development of a method employing reversed-phase thin-layer chromatography for establishing milk fat purity with respect to adulteration with vegetable oils. International Journal of Dairy Technology. 68(2): 207-217. doi. 10.1111/1471-0307.12178. \n22.\tGoyal, A., Siddiqui, S. Upadhyay, N., Soni, J. (2014). Effects of ultraviolet irradiation, pulsed electric field, hot water and ethanol vapours treatment on functional properties of mung bean sprouts. Journal of Food Science and Technology. 51(4): 708-714. doi 10.1007/s13197-011-0538-2. Publisher Springer. ISSN (electronic version): 0975-8402. \n23.\tKundu, H., Grewal, R.B., Goyal, A., Upadhyay, N.*, and Prakash S. (2014). Effect of incorporation of pumpkin (Cucurbita moshchata) powder and guar gum on the rheological properties of wheat flour. Journal of Food Science and Technology. 51(10):2600-2607. DOI: 10.1007/s13197-012-0777-x. ISSN: 0022-1155. \n24.\tUpadhyay, N.*, Kumar, A., Goyal, A. and Lal, D. (2014). A planar chromatographic method to detect adulteration of vegetable oils in ghee. JPC-Journal of Planar Chromatography-Modern TLC. 27 (6): 431-437. DOI: 10.1556/JPC.27.2014.6.5 \nNational Journals\n1.\tPonbhagavathi, T. R., Singh, A. K., Raju, P. N., Upadhyay, N. (2021). Textural and Sensory Characteristics of Milk Protein-Maize Flour-based Extrudates. Journal of Agricultural Engineering, 58(2), 124-136. 10.52151/jae2021581.1740\n2.\tPonbhagavathi, T.R., Singh, A.K., Raju, P.N., Upadhyay, N. (2020). Effect of Rennet Casein and Whey Protein Concentrate on Extrusion Behavior of Maize Flour. Current Journal of Applied Science and Technology. 39(33), 16-27, Article no.CJAST.57830.\n3.\tUpadhyay, N.*, Kumar, A., Lal, D., Kant, R., & Goyal, A. (2018). Detection of groundnut oil and goat body fat adulteration in ghee using principal component analysis on fatty acid profile. Indian Journal of Dairy Science. 71(5):464-472. \n4.\tUpadhyay, N.*, Kumar, A., Gandhi, K., Goyal, A. and Lal, D. (2014). Standardization of solvent fractionation technique for detection of adulteration in ghee by enriching animal body fat and vegetable oil in different fractions. Indian Journal of Dairy Science. 67 (4):323-327.\n5.\tGandhi. K., Upadhyay, N., Aghav, A.D., Sharma, V., and Lal, D. (2014). Detection of adulteration of ghee (clarified milk fat) with palmolein and sheep body fat using Reichert-Meissl (RM) value coupled with solvent fractionation technique. Indian Journal of Dairy Science. 67(5): 387-393. Received Second Best Paper Award during 44th Dairy Industry Conference organized by ICAR-NDRI, Karnal and Indian Dairy Association from 18-20, February 2016.\n6.\tAghav, A.D., Gandhi, K., Upadhyay, N., Kumar, A. and Lal, D. (2014). A study on the physico-chemical changes occurring in the milk fat during preparation of Paneer. Indian Journal of Dairy Science. 67 (5): 398-404.\n7.\tKumar, A., Upadhyay, N., Gandhi, K., Lal, D. and Sharma, V. (2013). Detection of soybean oil and buffalo depot fat in ghee using Normal-Phase Thin Layer Chromatography. Indian Journal of Dairy Science. 66(4): 294-99. ISSN: 0019-5146.\n8.\tKumar, A., Upadhyay, N., Gandhi, K., Kumar, A., Lal, D. and Sharma, V. (2013). Reverse-Phase Thin Layer Chromatography of Unsaponifiable Matter of ghee for detecting adulteration with soybean oil and buffalo depot fat. Indian Journal of Dairy Science. 66(6): 496-501. ISSN: 0019-5146.\n9.\tUpadhyay, N.*, Dabur R.S. and Rathi, M. (2011). Development and Shelf life Study of Flavoured Whey-soya milk beverage. Indian Journal of Dairy Science. 64(2): 92-101. ISSN: 0019-5146.\nOther Journals\n1.\tDewan, A., Meena, G.S., Upadhyay, N., Barapatre, R. Singh, A.K., Rana, J.S. (2017). Formulation of non-Gluten Pasta from the Optimized levels of Dairy and Non-Dairy ingredients. Madridge Journal of Food Technology. 2(2): 92–98. \n2.\tGalmessa, U., Prasad, S., Kumaresan, A., Oberoi, P. S., Baithalu, R. K., Upadhyay, N., and Dang, A. K. (2015). Modulation of Milk Fatty acid profile milk yield and composition through supplementation of omega-3 fatty acid in transition cow’s diet. Journal of Science and Sustainable Development. 3(1): 25-38. ISSN: 2070-1748\nREVIEW ARTICLES\n1.\tUpadhyay, N.*, Goyal, A. Kumar, A., Lal, D. and Singh, D. (2014). Preservation of milk and milk products for analytical purposes: A review. Food Reviews International. 30(3):203-224. DOI 10.1080/87559129.2014.913292. ISSN: 1525-6103\n2.\tGoyal, A., Sharma, V., Upadhyay, N., Gill, S. and Sihag, M. (2014). Flax and flaxseed oil: an ancient medicine & modern functional food. Journal of Food Science and Technology. 51(9): 1633-1653. DOI 10.1007/s13197-013-1247-9. ISSN: 0975-8402. \nBOOK CHAPTERS\n1.\tKumari, L., Sharma, M., & Upadhyay, N. (2021). Three-Dimensional Printing of Food Products: Printing Techniques, Novel Applications, and Printable Food Materials. Handbook of Research on Food Processing and Preservation Technologies: Volume 3: Computer-Aided Food Processing and Quality Evaluation Techniques, 55. Boca Raton, CRC Press\n2.\tUpadhyay, N.*, Harshitha, C. G., Pathak, N. K., & Sharma, R. (2021). Fourier Transform Infrared (FTIR) Spectroscopy with Chemometrics: Evaluation of Food Quality and Safety. Handbook of Research on Food Processing and Preservation Technologies: Volume 5: Emerging Techniques for Food Processing, Quality, and Safety Assurance, 271.\n3.\tNagarajappa, V., Upadhyay, N., Chawla, R., Mishra, S.K., & Nath, S. (2019). Functional Properties of Milk Proteins. In: Engineering Practices for milk products- Dairyceuticals, Novel Technologies, and Quality (pp 3-26). Apple Academic Press.\n4.\tUpadhyay, N., Kumar, M. C. T., Sharma, H., Borad, S., & Singh, A. K. (2019). Pulse Electric Field Processing of Milk and Milk Products. In: Non-thermal Processing of Foods (pp.129-144). Boca Raton, CRC Press\n5.\tUpadhyay, N., Nagaraj, V., & Singh, A. K. (2019). Advances in Fractionation of Milk Lipids: Analysis and Applications of fractions In: Recent Technologies in Dairy Science (pp. 325-344). Today and Tomorrow’s Printers and Publishers.\n6.\tNagaraj, V., Upadhyay, N.*, Nath, B. S., & Singh, A. K. (2018). Advances in Fractionation and Analysis of Milk Carbohydrates. In Technological Approaches for Novel Applications in Dairy Processing (pp. 127-147). IntechOpen. http://dx.doi.org/10.5772/intechopen.76312\n7.\tUpadhyay, N.*, Veena, N., Borad, S., & Singh, A. K. (2017). Application of Natural Antioxidants in Dairy Foods. In Natural Antioxidants (pp. 281-318). London: Apple Academic Press.\nINSTITUTE PUBLICATION\n1.\tDr. T. K. Datta, Dr. Meena Malik and Dr. Neelam Upadhyay (2017). Foundation Programme for Freshers at ICAR-NDRI 2017.\nPOPULAR AND LEAD ARTICLES\n1.\tPatil, A. T., Meena, G. S., Upadhyay, N., & Singh, A.K. (2017). Milk protein concentrates- Their Applications. Indian Dairyman, 69(9), 44-48.\n2.\tUpadhyay, N.* and R.K. Malik (2015). Nutritive Value of Milk. In: In Touch, Heinz Nutrition Foundation of India. Volume 17, Number 2&3, 2-11. (Lead Article). \n3.\tGoyal, A., Sharma, V., Upadhyay, N., Sihag, M. and Kaushik, R. (2013). High Pressure Processing and its impact on milk proteins: A Review. Research and Reviews: Journal of Dairy Science and Technology. 2 (1): 1-9. ISSN: 2319-3409.\n4.\tKumar, A., Upadhyay, N., and Naagar, S. (2012). Allergenicity of Milk Proteins, and its Management. Indian Food Industry. 31 (5&6): 45-50. ISSN: 0972-2610.\n5.\tGoyal, A. and Upadhyay, N. (2012). Nuclear Magnetic Resonance Spectroscopy in Dairy Science. Indian Food Industry. 31(1): 39-45. ISSN: 0972-2610.\n6.\tUpadhyay, N.*, Goyal, A. and Rathod, G. (2011). Microwave Spectroscopy and its applications in online processing. Indian Food Industry. 30(5&6): 63-73. ISSN: 0972-2610.\n7.\tउपाध्याय, नी*. (२०१८) भारत में कुपोषण: स्थिति और इससे निपटने के लिए रणनीतियाँ. दुग्ध—गंगा (आठवाँ अंक). अप्रैल-सितम्बर. २४-२९. \n8.\tउपाध्याय, नी.*, सिंह, आ.कु., गांगुली, स., सबिखी, ल. (२०१८) खाध्य और डेयरी क्षेत्र मे महिला उद्यमिता: कारण, समस्याए एवम उपलब्ध मंच. दुग्ध—गंगा (आठवाँ अंक). अप्रैल-सितम्बर. ६४-६९.\n9.\tउपाध्याय, नी*. (२०१९) ek¡ dk nw/k % f'k'kqvksa ds ekufld] 'kkjhfjd ,oa lkekftd mRFkku gsrq ve`r. दुग्ध—गंगा (नवाँ अंक). अकटूबर –मार्च १०२-१०४.\n10.\tउपाध्याय, नी*, fç;k ;koys (२०१९) [kk| inkFkksaZ esa —f=e ds cnys çk—frd jax o.kZd ds mi;ksx dh vko';drk दुग्ध—गंगा (दसवाँ अंक). अकटूबर –मार्च १०२-१०५.\n11.\tuhye mikè;k;, fuys'k dqekj ikBd (२०१९) d`f\"k] [kk| ,oa Ms;jh m|ksx ds Hkfo\"; eas lkSj ÅtkZ dk egRo दुग्ध—गंगा (दसवाँ अंक). अकटूबर –मार्च १२६-१३०. \n12.\tवैज्ञानिक और तकनीकी विषय के मूल हिंदी लेख जोकि गेहूँ एवम् जौ स्वर्णिमा में प्रकाशित हुए: उपाध्याय, नी*, राकेश कुमार (2020) महिला उद्यमिता के माध्यम से महिला सशक्तिकरण. गेहूँ एवम् जौ स्वर्णिमा (बारहवााँ अंक), पृष्ठ सं. 55-58; भाकृअनुप- भारतीय गेहूँ एवम् जौ अनुसंधान संस्थान, करनाल- १३२००१ द्वारा प्रकाशित\n\n8. Concepts/Processes/Products/Technologies/Patents/Others\n(i)\tConcepts \nCurrently, I am working on the integrated approach of application of green technology for the development of functional foods by utilizing under-utilized/ indigenous fruits and vegetables and/ or bio-waste. In the research projects, I am also keenly working on food chemistry and instrumental food analysis and applications of technologies/ products in dairy and non-dairy products. \nBesides this, I am working on development of functional food for addressing menopausal symptoms in osteopenic mice model. \n(ii)\tProducts/ Technologies ready for commercialization- 5\n1. Production of Milk Protein Concentrate 60 (MPC60), a high protein low lactose powder from buffalo milk (Co-Inventor)\n2. Technology for omega-3 rich mixed fat table spread (Inventor)\n3. Lipid and water soluble yellow natural colouring ingredient from bio-waste (Inventor)\n4. Technology for preparation of encapsulated flaxseed oil for its applications in foods (Inventor)\n5. Production of buffalo milk based Milk Protein Concentrate 60 (MPC60) powder with improved solubility (Co-Inventor)\n(iii) Expertise on\n1.Gas Liquid Chromatography\t5.Thin Layer Chromatography\n2.Fourier Transform Infra-red Spectroscopy\t6. Spectrophotometry\n3.Differential Scanning Calorimetry\t7.Chemical analysis including titration, distillation, etc.\n4.High Pressure Liquid Chromatography\t\n\n\n9. List of completed, on-going and submitted projects\nTitle of Project\tDuration\tRole\tFunding\tStatus\tRemarks\nEffect of storage on Baudouin test, sesamin test and RP-TLC test to detect adulteration of vanaspati and vegetable oils in ghee\t2015-2017\tCo-PI\tICAR-NDRI\n\tCompleted\tTwo research articles on RP-TLC\nPreparation and Characterization of Micro/nano delivery systems for “green” carotenoids\t2016-2019\tPI\t-Do-\t\t3 research articles+ 3 products/ technologies\nTechnology Development for the Production of Milk Protein Concentrate (MPC60) From Buffalo Milk\t2016-2019\tCo-PI\t-Do-\t\t4 research articles+ 2 products/ technologies\nTechnology of Goat Milk based Functional Beverage\t2017-2020\tCo-PI\t-Do-\t\tOne oral presentation\nTechnology for Moringa oleifera enriched cheese spread\t2020-2023\tPI\t-Do-\tOn-going\tCharacterization and incorporation of M. oleifera- pods in cheese spread is complete; shelf life study and animal trial is in progress\nDevelopment of flaxseed-rich probiotic dairy foods to address menopause symptoms\t2020-2023\tCo-PI\tDST\t\tDeveloped method -estimation of phytoestrogen; validation -in progress\nNutritional and therapeutic validation of chhachh and ghee prepared from indigenous cows by traditional method\tThree years (proposed)\tPI\tSEED Division, DST\tSubmitted \n \t\nCharacterization of Moringa oleifera leaves for functional bioactives and its application in table spread as model food system\tThree years (proposed)\tPI\tSYST, DST\t\t\nOther research work: \nDetection of adulteration of goat body fat and pig body fat in ghee using ATR-FTIR coupled with chemometrics; carried out during Professional Attachment Training at ICAR-CIPHET, Ludhiana\n\n\n\n10. Awards & honours \nName of Award\tYear\tAwarding Agency\nBest Paper Award\t2022\tGSAT (Gender Advancement for Transforming Institutions Self-Assessment Team), NDRI\nBest Poster Award\t2021\tNational Conference on Moringa Food Conclave-2021\nYoung Woman Scientist Award\t2020\tAgro Environmental Development Society during International Web-conference \nSecond Best Poster Award\t2020\tIndian Dairy Association\nCommendation certificate for Institute’s Magazine in which I am co-Editor\t2020\tTown Official Language Implementation Committee, Karnal\nLetter of Appreciation to editorial board of Institute’s magazine for receiving ICAR’s Second Prize and Trophy under Ganesh Shankar Vidyarthi Hindi Patrika Puraskar (2018-19)\t2020\tICAR- National Dairy Research Institute, Karnal\nAssociate Fellowship\t2019\tNational Academy of Dairy Science India\nFirst Prize in E-poster \t2018\tIndian Dairy Association\nOne Best oral Presentation\t2018\tHome Science Association of India\nBest Oral Presentation to my Master’s student\t2018\tICMR- National Institute of Nutrition\nBest Poster Award\t2016\tIndian Dairy Association\nSecond Best Paper Award\t2016\tIndian Dairy Association\nICAR-SRF (PGS) with 2nd rank\t2011-12\tICAR\nGATE (Engg Sciences: Food Tech; Thermodynamics)\t2010\tMHRD, GoI\nInstitution level awards\nThird prize in poster presentation \t2021\tICAR- National Dairy Research Institute, Karnal\nInstitute’s Rajbhasha Gaurav Certificate\t2020\t\nFirst prize in Scientific and Technical writing\t2019\t\nConsolation prize in Scientific and Technical writing \t2020, 2019 \t\nFirst prize in Poster Presentation- 2020, 2018, 2017\t\t\nThird prize in poster presentation\t2019\t\nFirst Prize in hindi extempore\t2017\t\nThird, first and second prize in hindi essay writing in consecutive years – 2020, 2019, 2018\t\t\n\n\n11. Teaching Assignments \n(a) Teaching: Actively involved either as course in-charge or associate \nClass\tB.Tech (DT)\tMSc/ MTech\n(FT) (till 2021)\tM.Tech (DT)\tPhD (DT/ DC/ FSQA)\nNo. of courses\t1-2\t2-3\t0-1\t2-3\nDT- Dairy Technology, DC- Dairy Chemistry, FT- Food Technology, FSQA- Food Safety Quality Assurance\n(b) Student’s guided\nDegree\tMajor Advisor \tCo-Advisory\tStatus/ Remarks\nM. Tech (DT)\t8\t2\tCompleted\n\t1\t0\tOn going\nM. Tech/ M Sc (FT/ FSN)\t2\t1\tCompleted\nM. Tech (DC)\t0\t3\tCompleted\nM. Tech (DM)\t0\t1\tCompleted\nPhD (DT)\t2 \t0\tOngoing \n\t0\t2\tCompleted\nPhD (DC)\t0\t1 \tCompleted\n\t\t1\tOn going\ni.\tThree students under my guidance as major advisor and one student as co-advisory member nominated for Best thesis award; \nii.\tOne represented NDRI at zonal-level student research convention ANVESHAN-2018\n\n12. Lectures/ member/convener of committees: \ni.\tLectures: \na.\tEntrepreneurship Development Programme (EDP) (conducted by SINED-TBI/BPD unit, ICAR-NDRI) and Online Training of Master Trainers on Fat and Oilseed processing conducted by SINED-TBI/BPD unit (ICAR-CIPHET); \nb.\tStudent’s Counselling session at SRCASW, University of Delhi, \nc.\tWorkshop conducted at DAV college, Karnal, etc\nd.\tDelivered talks at various villages on the importance of mother’s milk, nutrition in first 1000 days of an infant’s life, nutri-thali, etc\nii.\tTraining Organized: \na.\tTwenty one days Training at Centre for Advanced Faculty Training (DT Division) on ‘R & D strategies and interventions for effective agribusiness and entrepreneurship development in dairy and food sector’; \nb.\tone/two months or shorter duration trainings for students and others under BPD unit and KVK, NDRI, Karnal\nc.\tFive days training on the aspects of dairy processing to the farmers of Karnal district. \niii.\tGeneral Secretary, Staff Club, NDRI, Karnal\niv.\tMember: Student Empowerment Unit, Conferences organized from 2015 till 2018, convocation, credit seminar evaluation committees; Mera Gaon Mera Gaurav program, Farmer’s First Door programme, Swatchh Bharat Abhiyan, coordinator and mentor of different groups for organizing Foundation Program-2017, 2018, Nodal officer of Poshan Maah-2020 etc\nv.\tConvener/ Rapporteur of sessions: Conference, Dr. K. K. Iya Memorial oration; International conference of Proteomics Society of India\nvi.\tOther responsibilities: Management Representative of QMS-IS/ISO 9001:2008 and HACCP- IS 15000:2013 of Experimental Dairy (essential part of institute) until Jan 2019; one of the editors of Institute hindi magazine Dudgh Ganga which also received coveted award from ICAR (until 2019).\nvii.\tResource Generation on account of consultancy provided in field of dairy processing and by conducting sponsored trainings \nMore than ₹ 2 50 000/- (Two lakhs fifty thousand only)\nviii.\tBesides research, teaching and extension activities, I am also involved in promotion of Hindi language and have won several prizes during competitions (like extempore, essay, e-mail writing) organized by Official Language Units.\nix.\tLifetime Member of three scientific bodies: Indian Dairy Association- RE/NZ/LM/10852/HR; Association of Food Scientists & Technologists (INDIA)- AFST/LM/9-2018/KRN/2444; Lifetime member of Home Science Association of India; Membership number: HSAI-2017-HR-127-LF\nx.\tReviewed research papers of Journal of Ayurveda and Integrative Medicine (Elsevier), LWT, International Journal of Food Properties, Indian Journal of Dairy Science, Indian Journal of Natural Products and Resources, United Scientific Group, etc. \n\n\n\n\n\n\n\n\nDated: 12-04-2022\t \nNeelam Upadhyay",institutionString:"National Dairy Research Institute",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"National Dairy Research Institute",institutionURL:null,country:{name:"India"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"5",title:"Agricultural and Biological Sciences",slug:"agricultural-and-biological-sciences"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"444312",firstName:"Sara",lastName:"Tikel",middleName:null,title:"Ms.",imageUrl:"https://mts.intechopen.com/storage/users/444312/images/20015_n.jpg",email:"sara.t@intechopen.com",biography:"As an Author Service Manager, my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. 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1. Introduction
In Air Traffic Control (ATC), controller workload has been an important topic of research. Many studies have been conducted in the past to uncover the art of evaluating workload. Many of which have been centered on the sector complexity or task demand based studies [1,2,3,4]. Moreover, all have the aim to understand the workload that was imposed on the controller and the extent to which the workload can be measured.
With the growth in world passenger traffic of 4.8% annually, the volume of air traffic is expected to double in no more than 15 years [5]. Although more and more aspects of air transportation are being automated, the task of supervising air traffic is still performed by human controllers with limited assistance from automated tools and is therefore limited by human performance constraints [6]. The rise in air traffic leads to a rise in the Air Traffic Controller (ATCO) task load and in the end the ATCO’s workload itself.
The 2010 Annual Safety Review report by European Aviation Safety Agency (EASA) [7] indicates that since 2006, the number of air traffic incidents with direct or indirect Air Traffic Management (ATM) contribution has decreased. However, the total number of major and serious incidents is increasing, with incidents related to separation minima infringements bearing the largest proportion. This category refers to occurrences in which the defined minimum separation between aircraft has been lost. With the growth of air traffic, combined with the increase of incidents relating to separation minima infringements, a serious thought have to be put into investigating the causes of the incidents and plans on how to solve them.
Initiatives to design future ATM concepts have been addressed in both Europe and the United States, within the framework of Single European Sky ATM Research (SESAR) [8] and Next Generation Air Transportation System (NextGen) [9]. An increased reliance on airborne and ground-based automated support tools is anticipated in the future ATM concept by SESAR and NEXTGEN. It is also anticipated that in both SESAR and NEXTGEN concepts a better management of human workload will be achieved. However, to enable that, a more comprehensive understanding of human workload is required, especially that of controllers.
This chapter wil start with a discussion on sector complexity and workload and is followed by a deliberation of previous and current sector complexity and workload measures. Next, a method called the Solution Space Diagram (SSD) is proposed as a sector complexity measure. Using the SSD, the possibility of measuring different sector design parameters are elaborated and future implications will be discussed.
2. Sector complexity and workload
ATCO workload is cited as one of the factors that limit the growth of air traffic worldwide [10,11,12]. Thus, in order to maintain a safe and expeditious flow of traffic, it is important that the taskload and workload that is imposed on the ATCO is optimal. In the effort to distinguish between taskload and workload, Hilburn and Jorna [1] have defined that system factors such as airspace demands, interface demands and other task demands contribute to task load, while operator factors like skill, strategy, experience and so on determine workload. This can be observed from Figure 1.
Figure 1.
Taskload and Workload Relation [1].
ATCOs are subject to multiple task demand loads or taskloads over time. Their performance is influenced by the intensity of the task or demands they have to handle. Higher demands in a task will relate to a better performance. However, a demand that is too high or too low will lead to performance degradation. Thus, it is important that the demand is acceptable to achieve optimal performance.
The workload or mental workload can be assessed using a few methods such as using performance-based workload assessment through primary and secondary task performance, or using subjective workload assessment through continuous and discrete workload ratings, and lastly using physiological measures. However, because physiological measures are less convenient to use than performance and subjective measures, and it is generally difficult to distinguish between workload, stress and general arousal, these are not widely used in assessing workload [13].
Previous studies have also indicated that incidents where separation violations occurred can happen even when the ATCO’s workload is described as moderate [14,15]. These incidents can be induced by other factors such as inappropriate sector design. Sector design is one of the key components in the airspace complexity. Airspace complexity depends on both structural and flow characteristics of the airspace. The structural characteristics are fixed for a sector, and depend on the spatial and physical attributes of the sector such as terrain, number of airways, airway crossings and navigation aids. The flow characteristics vary as a function of time and depend on features like number of aircraft, mix of aircraft, weather, separation between aircraft, closing rates, aircraft speeds and flow restrictions. A combination of these structural and flow parameters influences the controller workload [16].
A good airspace design improves safety by avoiding high workload for the controller and at the same time promotes an efficient flow of traffic within the airspace. In order to have a good airspace design, the ATC impact of complexity variables on controller workload has to be assessed. Much effort has been made to understand airspace complexity in order to measure or predict the controller’s workload. In this chapter the solution space approach is adopted, to analyze in a systematic fashion how sector designs may have an impact on airspace complexity, and ultimately the controller workload.
2.1. Previous research on complexity factors
The Air Traffic Management (ATM) system provides services for safe and efficient aircraft operations. A fundamental function of ATM is monitoring and mitigating mismatches between air traffic demand and airspace capacity. In order to better assess airspace complexity, methods such as ‘complexity maps’ and the ‘solution space’ have been proposed in Lee et. al [17] and Hermes et al. [18]. Both solutions act as an airspace complexity measure method, where a complexity map details the control activity as a function of the parameters describing the disturbances, and the solution space details the two-dimensional speed and heading possibilities of one controlled aircraft that will not induce separation violations.
Much effort has been made to understand airspace complexity in order to measure the controllers’ workload. Before introducing the solution space approach, first some more common techniques are briefly discussed.
2.1.1. Static density
One of the methods to measure complexity is the measurement of aircraft density and it is one of the measures that are commonly used to have instant indication of the sector complexity. It is defined as the number of aircraft per unit of sector volume. Experiments indicated that, of all the individual sector characteristics, aircraft density showed the largest correlation with ATCO subjective workload ratings [19,20]. However, aircraft density has significant shortcomings in its ability to accurately measure and predict sector level complexity [19,21]. This method is unable to illustrate sufficiently the dynamics of the behavior of aircraft in the sector. Figure 2 shows an example where eight aircraft flying in the same direction do not exhibit the same complexity rating when compared to the same number of aircraft flying with various directions [18].
Figure 2.
Example of Different Air Traffic Orientation.
2.1.2. Dynamic density
Another measurement of sector complexity is dynamic density. This is defined as “the collective effort of all factors or variables that contribute to sector-level ATC complexity or difficulty at any point of time” [19]. Research on dynamic density by Laudeman et al. [22] and Sridhar et al. [16] has indicated few variables for dynamic density and each factor is given a subjective weight. Characteristics that are considered include, but not limited to the number of aircraft, the number of aircraft with heading change greater than 15° or speed change greater than 10 knots, the sector size, and etc. The calculation to measure dynamic density can be seen in Equation (1).
Dynamic Density=∑i=1nWiDViE1
\n\t\t\t\t\t
where dynamic density is a summation of the Dynamic Variable (DV) and its corresponding subjective weight (W). The calculation of the dynamic density is basically based on the weights gathered from regression methods on samples of traffic data and comparing them to subjective workload ratings. Essentially, the assignment of weights based on regression methods means that the complexity analysis based on dynamic density could only be performed on scenarios that differ slightly from the baseline scenario. Therefore the metric is not generally applicable to just any situation [18].
2.1.3. Solution space-based approach
Previous work has shown that the SSD is a promising indicator of sector complexity, in which the Solution Space-based metric was proven to be a more objective and scenario-independent metric than the number of aircraft [18,23,24]. The Forbidden Beam Zone (FBZ) of Van Dam et al. [25] has been the basis for representing the SSD. It is based on analyzing conflicts between aircraft in the relative velocity plane. Figure 3 (a) shows two aircraft, the controlled aircraft (Acon) and the observed aircraft (Aobs). In this diagram, the protected zone (PZ) of the observed aircraft is shown as a circle with radius of 5NM (the common separation distance) centered on the observed aircraft. Intrusion of this zone is called a ‘conflict’, or, ‘loss of separation’. Two tangent lines to the left and right sides of the PZ of the observed aircraft are drawn towards the controlled aircraft. The area inside these tangent lines is called the FBZ.
This potential conflict can be presented on a SSD. Figure 3 (b) shows the FBZ in the SSD of the controlled aircraft. The inner and outer circles represent the velocity limits of the controlled aircraft. Now, if the controlled aircraft velocity lies inside the triangular-shaped area, it means that the aircraft is headed toward the PZ of the observed aircraft, will eventually enter it, and separation will be lost.
The exploration of sector complexity effects on the Solution Space parameters and, moreover, workload is important in order to truly understand how workload was imposed on controllers based on the criteria of the sector. Having the hypotheses that sector parameters will have a direct effect on the SSD geometrical properties, the possibility of using the SSD in sector planning seems promising. Figure 4 shows the relationship between taskload and workload as described by Hilburn and Jorna [1], where we adapted the position of sector complexity within the diagram. The function of the SSD is included as a workload measure [18,23,24] and alleviator [26] and also the possibility of aiding sector planning through SSD being a sector complexity measure [24].
Figure 3.
Two Aircraft Condition (a) Plan View of Conflict and the FBZ Definition. (b) Basic SSD for the Controlled Aircraft. (Adapted from Mercado-Velasco et al., [26])
Initial work by Van Dam et al. [25] has introduced the application of the Solution Space in aircraft separation problems from a pilot’s perspective. Hermes et al. [18], d’Engelbronner et al. [23], Mercado-Velasco et al. [26] and Abdul Rahman et al. [24] have transferred the idea of using the Solution Space in aircraft separation problems for ATC. Based on previous research conducted, a high correlation was found to exist between the Solution Space and ATCO’s workload [18,23,24]. Abdul Rahman et al. [24] also investigated the possibility of measuring the effect of aircraft proximity and the number of streams on controller workload using the SSD and have discovered identical trends in subjective workload and the SSD area properties. Mercado-Velasco et al. [26] study the workload from a different perspective, looking at the possibility of using the SSD as an interface to reduce the controller’s workload. Based on his studies, he indicated that the diagram could indeed reduce the controller’s workload in a situation of increased traffic level [26].
Figure 4.
Solution Space Diagram in Measuring and Alleviating Workload (adapted from Hilburn and Jorna [1])
3. Complexity measure using the solution space diagram
The results gathered here are based on offline simulations of more than 100 case studies with various situations as detailed in this chapter. The affected SSD area has been investigated to understand the effects of sector complexities on the available solution space. Conclusions from previous work by Hermes et al. [18] and d’Engelbronner et al. [23] stated that the available area in the Solution Space that offers solutions has a strong (inverse) correlation with ATCO workload. In this case study, two area properties were investigated in order to measure the complexity construct of the situation, which are the total area affected (Atotal) and the mean area affected (Amean) for the whole sector. The Atotal percentage is the area covered by the FBZs as a percentage of the total area between the minimum and the maximum velocity circles in the SSD, based on the currently controlled aircraft. The Amean percentage affected is the Atotal affected for all aircraft in the sector divided by the number of aircraft. This will give an overview of the complexity metric for the whole sector.
Atotal=∑AaffectedE2
\n\t\t\t
Amean=∑t=1nAtotaltnE3
\n\t\t\t
Both measures were used as a complexity measure rating, based on the findings in earlier studies where the Atotal and Amean showed to have a higher correlation with the controller’s workload than the static density [24].
4. Sector complexity variables
Previous research on sector complexity showed that the aircraft intercept angle [27,28,29], speed [27] and horizontal proximity [3,16] are some of the variables that are responsible for the sector complexity. The goal of the present study is to systematically analyze the properties of the SSD due to changes in the sector design. It is hypothesized that using these properties we can obtain a more meaningful prediction of the sector’s complexity (or task demand load) than existing methods.
In a first attempt, we studied the effects of aircraft streams’ (that is, the airways or routes) intercept angles, the speed differences and horizontal proximity between aircraft, and also the effect of number of aircraft and their orientation on the SSD. For this purpose, several cases were studied. The cases that were being investigated involved two intercepting aircraft at variable intercept angles, route lengths, and speed vectors. Quantitative analysis was conducted on the SSD area properties for the mentioned sector variables. In the study of quantitative measurement of sector complexity, it was assumed that a denser conflict space results in a higher rating for the complexity factor. IIn later stage, a human-in-the-loop experiment will be conducted to verify the hypotheses gathered from the quantitative study and will provide a better understanding on the relationship between the SSD area properties and the workload as indicated by the subject. Figure 5 shows an example of one of the case studies with the speed vectors, route length, horizontal proximity, initial position, corresponding angle between the aircraft and the intercept angle properties. One sector complexity factor was changed at the time in order to investigate the effects of that factor on the SSD. Changes in these factors will be translated into differences in the geometry of the FBZ and area affected on the SSD.
Figure 5.
Example of Case Study Properties
The diagram we hereby elaborate is based on three important assumptions. First, both aircraft are on the same flight level and are not ascending or descending during the flight. Secondly, it is assumed that both aircraft have the same weight classes and will have the same minimum and maximum velocities. Lastly, the minimum separation distance, represented by a PZ with radius of 5 NM around each aircraft, is to be maintained at the same size at all time. Different complexity factors are compared using a quantitative analysis.
4.1. Horizontal proximity
Previous research on sector complexity has shown that the aircraft horizontal proximity [3,16] is one of the variables that is responsible in the sector complexity construct. There are several relationships that can be gathered from the FBZ. In order to analyze the relationship between FBZ and time to conflict and the position of aircraft, some parameters have to be determined. These parameters can be found in Figure 6 where the absolute and relative space of the FBZ was illustrated in Figure 6 (a) and (b), respectively. In the absolute space (Figure 6 (a)), two aircraft situation with distance between aircraft (d) and minimum separation distance (R) were illustrate. The FBZ is then translated into the relative space (Figure 6 (b)) where the same situation was projected with the assumption that the controlled aircraft will be in direct collision with the observed aircraft in the future. Based on the figures, it is observed that the FBZ and the corresponding Solution Space share similar geometric characteristics. These, as shown in Figure 6, make it clear that:
The separation between aircraft in terms of time and horizontal proximity can be directly observed on the SSD through the width of the FBZ. A narrow FBZ translates to a longer time until loss of separation and also a larger separation distance between both aircraft. The relation can be seen in Equation (5) [34] and Equation (6), where the time (t) and distance between aircraft (d) is inversely proportional to the width (w) of the FBZ.
w=2RtcosαE5
\n\t\t\t\t
w=2RVreldcosαE6
\n\t\t\t\t
The importance of horizontal proximity has also been stressed in other research where it is indicated that aircraft that fly closer to each other have a larger weight on the Dynamic Density [3,16]. In order to see the effect of horizontal proximities on the SSD and to confirm the previous study, more than 50 position conditions with intercept angle of either 45°, 90° or 135°, were studied. To simulate horizontal proximity, aircraft were assigned with a different route length at a different time instance. It is important to ensure that only one property is changed at a time. During this study, the velocity of both aircraft was maintained at same speed at all times. The effect of the horizontal proximity on the SSD is shown in Figure 7. The situation in Figure 7 is based on aircraft flying with a fixed heading angle of 90°, while both aircraft having the same speed vector of 200 knots, but having a different route length.
Figure 7.
SSD for AC2 Observing Horizontal Proximity Changes.
From the analysis, it was found that aircraft that are further apart from each other have a narrower FBZ width than the ones being closer to each other. This can be seen in Figure 7 with aircraft progressing from being nearest (Figure 7 (a)) to furthest (Figure 7 (d)) apart from one another. The same pattern also applies to other intercept angles studied. The area affected is less dense for aircraft with a larger horizontal proximity where the area affected within the SSD decreases from 11% for the case in Figure 7 (a) to 6% for case in Figure 7 (d). This also shows that a large horizontal separation between aircraft result in a less dense SSD, thus a lower complexity metric. A narrower width also implicate that there are more options to solve a conflict. This can be seen in Figure 7, where in Figure 7 (a) and (b), there is no room for AC2 to resolve the conflict using a speed-only correction, whereas in Figure 7 (c) and (d) the conflict can be resolve by either increasing or decreasing the AC2 speed.
Similar patterns were observed with different speed settings and speed boundaries in conjunction with different intercept angles. Figure 8 illustrates the percentage area covered as a function of the horizontal distance and the intercept angle while having the same velocity vector. It can be seen from this figure that the area properties decrease with larger distances between both aircraft at any intercept angle. The regression rate of the SSD area properties against the horizontal distance is also similar with any other intercept angle as indicated by Equation (6) regarding the width of the FBZ.
Figure 8.
Percent Area Covered with Distance for Different Intercept Angle
4.2. Speed variations
A previous study by Rantenan and Nunes [27] has suggested speed as a confounding factor to conflict or intercept angles and the ability to detect a conflict. It was indicated in their research that increasing the speed differential between converging objects increased the temporal error, resulting in a lower accuracy. This is due to the fact that the controller now has to integrate two (rather than one) pieces of speed information and project their implications. This shows the importance of studying the effect of speed variations to the sector complexity, especially when coupled with the intercept angle.
A number of cases of aircraft pairs at the same distance between each other were investigated in this preliminary study. The first observation is illustrated in Figure 9 where the speed and the heading of the observed aircraft can be seen on the SSD mapping of the controlled aircraft through the position of the tip of the FBZ. This is because the FBZ is obtained by transposing the triangular-shaped conflict zone with the observed aircraft velocity vector. In a case such as seen in Figure 9 (a) to (c), an aircraft with the same horizontal separation at an intercept angle of 90° between each other will result in a different SSD as a function of the 150, 200 and 250 knots speed settings.
Figure 9.
SSD of AC2 observing speed changes for the same aircraft position. (a) AC1 at 150 knots. (b) AC1 at 200 knots. (c) AC1 at 250 knots.
In Figure 9, AC1 will encounter a separation violation problem in the future with AC2 when the aircraft maintains its current heading and speed. However, giving speed or heading instructions to one or both aircraft can resolve the future separation issue. In this case, an increase (Figure 9 (a)) or decrease (Figure 9 (c)) in speed for AC2 will solve the future separation issue. It is not desired for on-course aircraft to change the heading angle in order to fulfill efficiency constraints, however, if required to maintain safety, it may be the proper way to resolve a conflict, such in Figure 9 (b). It is found that the higher the speed of the observed aircraft, the more the FBZ in the SSD is shifted outwards. The changes in the speed only affect the currently controlled aircraft’s SSD. Because there is no change of speed for the controlled aircraft, AC2, the corresponding diagram for AC1 observing AC2 remains the same during the change of speed vector in AC1.
The total area affected on the SSD depends on the relative positions and the intercept angle of both aircraft, where a shift outwards will be translated as more or less SSD area percentage affected. This can be seen by comparing Figure 9 (a) to (c) where a shift outwards results in more area affected within the SSD, which gives the value of 8%, 11% and 15% area affected for cases (a), (b), (c), respectively. Hence it can be hypothesized that larger relative speeds can result in a higher or lower complexity metric, depending on the position and intercept angle of the aircraft.
The effect of speed differences was also investigated further for aircraft intercepting at 45°, 90° and 135° with more possible cases, and the results are illustrated in Figure 10. Differences in intercept angle, speed limit band (which may represent differences in aircraft performance limits or aircraft types) and the size of the speed limit were investigated. Figure 10 shows the effect of speed differences on a 180 - 250 knots speed band, with both AC1 and AC2 at either 30 NM or 40 NM distance from the interception point at different intercept angles. Both aircraft’s initial speeds were 250 knots and to illustrate the effect of speed variations, one of the aircraft was given a gradual speed reduction toward 180 knots.
Figure 10.
The SSD area values as a function of different speed settings for same aircraft position with different intercept angles.
The diamond shapes in Figure 10 indicate the minimum difference needed for aircraft not to be in a future separation violation. Based on Figure 10, the effect of speed and distance is evident with 45°, 90° and 135° intercept angles showing a decrease in the SSD area properties with a larger relative distance while maintaining the trends of the graph. In 90° and 135° cases, larger distances also indicated that a smaller speed difference (marked with diamond) was needed in order for both aircraft not to be in a future separation violation. Figure 10 also shows that aircraft flying at a smaller intercept angle needed less speed difference than aircraft flying larger intercept angle to avoid future separation violation caused by having the same flight path length to the intercept point.
The effect of the intercept angle on the other hand shows different patterns in SSD area properties in regards to the speed variations. A 45° intercept angle showed an increase of SSD area properties up until the intermediate speed limit followed by a decrease of SSD area properties with increased speed differences. However, for 90° and 135° intercept angle cases, the reduction of speed is followed by a continuing decrease in SSD area properties.
Differences in the pattern also indicated a difference in sector complexity behavior toward distinctive intercept angle. The effects of speed limit bands for 45° intercept angle cases are illustrated in Figure 11 and 12. Figure 11 (a) shows the effect of different speed band values while maintaining the same size of the controlled aircraft speed performance and Figure 12 (b) shows the effect of different sizes of the speed band. Based on both figures, irrespective of the speed band ranges (aircraft speed performance limit) or speed band size, the same pattern in area properties were found, in all eight scenarios. The only difference was the peak value of the SSD area properties (Figure 11 (a)) is greater for speed bands with higher speed limits. This is due to the fact that with the same position between both aircraft, higher speed (for AC1 in this case) indicates a higher possible relative speed (Vrel) for the maximum speed band, thus implicating a broader FBZ (can be seen in Equation (6) and Figure 11 (b)). The same pattern was illustrated with different speed band sizes (Figure 12) with higher peaks of the SSD area values for higher AC1 speeds.
Figure 11.
a) Various speed settings for the same 45 Degree Intercept Angle with different speed limit boundaries (b) Different speed band maximum limit of the controlled aircraft
Figure 12.
a) Various speed settings for the same 45 Degree Intercept Angle with different speed band size (b) SSD of Different speed band sizes.
4.3. Intercept angle
Based on previous researches, the ability of the controller to ascertain whether or not an aircraft pair will lose separation (more commonly known as conflict detection) is affected by a variety of variables that include, but are not limited to, the convergence angle [27,28,29]. However, previous research also found that conflict angle as a factor affecting conflict detection ability, is often confounded with speed [27]. Nonetheless, in order to understand the intercept angle as part of the sector complexity measure, the effect of intercept angle on the SSD area property is important.
There are several types of crossing angles that are being studied. The main goal of the study was to investigate the effect of crossing angle towards sector complexity through the SSD. The effect of different intersection angles on the SSD is shown here for the case where the route length between AC1 and AC2 remains constant and equal at all time. Both aircraft were flying the same speed vector of 200 knots, but with different heading angles for AC2, which are 45°, 90° and 135°. The negative intercept angles were assigned for aircraft coming from the left, while positive intercept angles were assigned for aircraft coming from right. As seen here, only the changes in the heading angle were investigated, while other variables were fixed to a certain value.
From the analysis, it is found that the larger the heading angles of intersecting aircraft, the less dense the area within the SSD. Figure 13 shows the resulting SSD for different intercept angles. Figure 13 also shows the effect of aircraft coming from right (Figure 13 (a) to (c)) or from the left (Figure 13 (d) to (e)) side of the controlled aircraft. It is concluded here that aircraft coming from any direction with the same intercept angle and route length will demonstrate the same complexity measure due to the symmetrical nature of the conflict For aircraft with 45°, 90° and 135° intercept angles, the SSD area properties are 14%, 11% and 8%, respectively. The same area properties hold for the opposite angle. This also shows that a larger intercept angle results in a lower complexity metric based on the properties of the SSD, because the solution area covered with the conflict zone is smaller. However, this condition only applies if the observed aircraft has a route length larger or equal to the controlled aircraft. This also means that the condition where the effects of intercept angles on the complexity metric is only valid when the observed aircraft is approaching from a certain direction.
Figure 13.
SSD for AC1 observing different heading angle for same aircraft speed. (a) AC2 at 45°. (b) AC2 at 90° (c) AC2 at 135° (d) AC2 at -45°. (e) AC2 at -90° (f) AC2 at -135°.
4.3.1. Front side and backside crossings
It was found that there are differences between observing an aircraft crossing in front or from the backside of the controlled aircraft with an increasing intercept angle. A case study was conducted where an aircraft observed front side and backside crossings at an angle of 45° and 135°. Both aircraft had the same speed of 220 knots and intercepted at the same point of the route, giving the same flight length for each case observed (see Figure 5). In a case where the controlled aircraft, which was farther away, was observing an intercept of an observed aircraft crossing in front at a certain angle, the area affected was increasing with an increasing intercept angle. The area affected measured in this case was 3% for 45° intercept angle (Figure 14 (a)) compared to 5% area affected for the 135° intercept angle (Figure 14 (b)). On the other hand, in a case where the controlled aircraft was observing an aircraft crossing from the backside, the area affected was decreasing with increasing intercept angle. The area affected measured in this case is 8% for 45° intercept angle (Figure 14 (c)) compared to 3% for 135° intercept angle (Figure 14 (d)). These area-affected values concluded that a slightly higher complexity metric was found with an increasing intercept angle when the observed aircraft was already present in the sector and passing the controlled aircraft from the front side. The opposite situation appeared when the observed aircraft was approaching a sector and crossed the observed aircraft from the backside.
Figure 14.
a) Observed Aircraft Crossing from the front side at 45° (b) Observed Aircraft Crossing from the front side at 135° (c) Observed Aircraft Crossing from the backside at 45° (d) Observed Aircraft Crossing from the backside at 135°.
To extensively study the effect of intercept angle and the relative aircraft distance on the SSD area properties, several other cases were looked into and the results are illustrated in Figure 15. Figure 15 showed static aircraft at 35 NM distance from the intercept point, observing an incoming or a present aircraft in the sector at a variable intercept angle. Based on the initial study, it can be seen that observing present aircraft in the sector (with a distance from the intercept point less than 35 NM) will lead to an increase of SSD area properties with an increasing intercept angle. Despite this result, it was observed that a larger intercept angle for incoming aircraft (aircraft with distance more than 35 NM) results in a less dense area inside the SSD with an increasing intercept angle. The results gained here, matches the initial observations discussed earlier.
Figure 15.
Plots of SSD Behavior showing the Differences in Intercept Angle and Distance to Intercept Point
Figure 16.
Plots of SSD Behavior showing the Differences in Intercept Angle and Distance to Intercept Point
Figure 16 shows the effect of intercept angle and the relative aircraft distance to the intercept point from a different perspective, where the effect of different intercept angle on the distance towards the intercept point was focused. From the figure it is observed that a larger distance for larger intercept angles (120°, 135° and 150°) results in a continuing decrease of SSD area properties, thus relating to a lower complexity metric, whereas a larger distance for smaller intercept angles (30° to 90°) result in an initial increase of SSD area properties, thus relating to a larger complexity metric and followed by decreasing SSD area properties after a certain distance (more than 35 NM). This also suggested that for a bigger intercept angle, the increase in distance always relates to a less complex situation whereas for a smaller intercept angle, the increase of distance up to a point where the length path is equal relates to a more complex situation.
4.3.2. Time to conflict
The effect of intercept angle on the sector complexity construct was also investigated from a different perspective, namely the Time to Conflict (TTC). As illustrated in Figure 17 (a), with a fixed TTC at 500 seconds, a larger conflict angle will result in lower SSD area properties, thus a lower sector complexity construct. However, this can be due to the larger distance between the aircraft for larger conflict angles, even with the same TTC value. Having said that, this also indicates that with a larger intercept angle, a later conflict detection and lower initial situation awareness are predicted. An example of the progression of a future conflict that will occur at an equal time in the future with different conflict angles is shown in Figure 17 (b). Based on Figure 17 (b), a larger conflict angle results in lower SSD area properties, and also has a faster rate of SSD progress toward total SSD occupation.
Figure 17.
a) SSD Area Properties for Different Conflict Angle Properties of Aircraft with the Same TTC. (b) SSD Area Progression with TTC for Different Conflict Angle
4.4. Number of aircraft and aircraft orientation
One of the methods to measure sector complexity is through the measurement of aircraft density. Aircraft density is one of the measures that is commonly used to have instant indication of the sector complexity. It is defined as the number of aircraft per unit of sector volume. This section discusses the effects of the number of aircraft within a sector on the SSD area properties together with the aircraft heading orientations. Figures 18 and 19 show the number of aircraft and the traffic orientation that was investigated here. An example SSD for two aircraft, AC1 and AC2 as indicated in Figure 18 and 19 were illustrated for all cases. For all four situations, all aircraft are free of conflicts. In a four-aircraft situation, illustrated in Figures 18 (a) and (d), an Amean of 9% and 16%, respectively, were gathered whereas in a six-aircraft situation, illustrated in Figure 19 (a) and (d), an Amean of 15% and 20%, respectively were gathered. Based on the SSD area properties, it was clear that more aircraft relates to a higher SSD area properties comparing cases in Figure 18 (a) to Figure 19 (a). The corresponding SSD also illustrates the effect of adding two aircraft to AC1 and AC2 where additional two FBZ were present in Figure 19 (b) and (c) if compared to Figure 18 (b) and (c).
This case study also agrees with the notion that aircraft orientation also influences the complexity construct of a sector through cases illustrated in Figure 18 and Figure 19. Here it can be seen that cases with converging aircraft ((Figure 18 (d) and\n\t\t\t\t\tFigure 19 (d)) result in higher SSD area properties than cases where all aircraft have an equal heading (Figure 18 (a) and\n\t\t\t\t\tFigure 19 (a)). The SSD also showed the effect of heading with Figure 18 (b) and (c) showing the FBZ of aircraft with one heading and Figure 18 (e) and (f) showing the FBZ of aircraft with several headings. The same four- aircraft situation in Figure 18 and six-aircraft situation in Figure 19 showed to be more complicated with several aircraft headings. The area properties of the situation in Figure 18 (d) (Amean of 16%) and Figure 19 (a) (Amean of 15%) also showed that the SSD has the potential to be a good sector complexity measure that is, it has the capability to illustrate that more aircraft does not necessarily mean higher complexity, but that the orientation of aircraft within the sector matters more.
Figure 18.
Different heading for same aircraft position. (a) Four Aircraft in One Heading. (b) SSD AC1. (c) SSD AC2. (d) Four Aircraft in Several Heading. (e) SSD AC1. (f) SSD AC2.
Figure 19.
Different heading for same aircraft position. (a) Six Aircraft in One Heading. (b) SSD AC 2. (c) SSD AC 4. (c) Six Aircraft in Several Heading. (e) SSD AC 2. (f) SSD AC 4.
5. Solution space diagram in measuring workload
The complexity construct is an intricate topic. It is interrelated between multiple complexity variables, and altering one variable in a single scenario may result in changing other aspects of complexity. In order to measure complexity, it is hypothesized that sector complexity can be measured through the controller’s workload based on the notion that the controller workload is a subjective attribute and is an effect of air traffic complexity [30]. The controller’s workload can be measured based on a subjective ratings in varying scenario settings. From the many different measurement techniques for subjective workload, the Instantaneous Self Assessment (ISA) method is one of the simplest tools with which an estimate of the perceived workload can be obtained during real-time simulations or actual tasks [33]. This method requires the operator to give a rating between 1 (very low) and 5 (very high), either verbally or by means of a keyboard, of the workload he/she perceives.
While the problems encountered in Air Traffic Control have a dynamic character and workload is likely to vary over time because of the changes in the traffic situation that an ATCO is dealing with, the measurement of workload through ISA should also be made at several moments in time. To enable the SSD to become an objective sector complexity and workload measure, the correlation between the subjective ratings given by participant and the SSD area properties should be studied at several moments in time. Figure 20 shows examples of correlation study between SSD area properties and workload [24]. The plots show the subjective workload ratings in conjunction with the SSD area properties taken every minute in six different scenarios per subject. A total of 120 subjective ratings were gathered together with 120 SSD instants where SSD area assessments were conducted. With these practice, the correlation between SSD area properties and workload as indicated by controller can be evaluated.
Figure 20.
Atotal and Amean Plots Together with the Subjective Workload Rating as Indicated by Subject [24].
Previous experiments have shown that using the SSD area properties, a higher correlation than the static density was found [23,24]. The possibility of using the SSD in measuring workload as a function of different sector design parameters were also explored with the SSD area properties and showed to be capable of illustrating the same trend in the complexity measure with the ISA ratings [24]. However, to understand more on the complexity construct, a more focused study is needed to study different sector complexity effects on the SSD such as the number of streams, the orientation of the streams, the position of in-point and out-point of a route within the sector and etc. This preliminary study will then serve as the driver of a more elaborated research in the future.
6. Future research
The exploration of sector complexities on the Solution Space parameters and moreover workload is important in order to truly understand how workload is imposed on controllers. Because this preliminary investigation showed that various sector parameters and traffic properties are reflected by the geometry of conflict and solution spaces geometry in the SSD, the possibility of using the SSD in sector planning seems promising. This has also opened up a possibility of quantifying workload objectively using the SSD as a sector complexity and workload measure. Apart from using the SSD for offline planning purposes, having the capability to quantify sector complexity and/or workload has also a potential role in dynamic airspace assessment. This enables a more dynamic airspace sectorization or staff-planning than using the conventional maximum-number-of-aircraft limit that is primarily driven by the air traffic controller’s ability to monitor and provide separation, communication and flow-control services to the aircraft in the sector.
Other than using the SSD as a sector planning aid, it is also envisioned that in the future, the SSD can be used as an operation tool. It is anticipated that by using the SSD as a display, controllers will have an additional visual assistance to navigate aircraft within the airspace. The SSD can serve as a collision avoidance tool or also a support tool for ATCOs, to indicate sector bottlenecks and hotspots.
Finally, the possibility of implementing the SSD in a three-dimensional problem is not far to reach. Initial studies have been conducted on an analytical 3D SSD [31] and an interface-based 3D SSD [32]. In the analytical solution, the 3D SSD area for the observed aircraft (Aobs) were comprised of two intersecting circles (both from the top and the bottom of the protected area) and the flight envelope of the controlled aircraft (Acon) comprising the rotation of the performance envelope around its vertical axis with 360 degrees, resulting in a donut-shaped solution space. A simplified diagram of the solution space constructed by the protected area of the observed aircraft and the flight envelope of the controlled aircraft is illustrated in Figure 21. Further studies need to be conducted to verify the capability of the 3D SSD in efficiently measuring workload or sector complexity.
Figure 21.
Two Aircraft in 3 Dimensional Conditions.
In a different study, the altitude dimensional was integrated into a 2D-based SSD ATCO display [32]. The altitude extended SSD was calculated by filtering the aircraft in accordance to their Altitude Relevance Bands and cut off the SSD conflict zones by the slowest and fastest possible climb and descent profiles. In this way, the algorithm can discard conflict zones that can never lead to a conflict. Based on this algorithm, a display prototype has been developed that is able to show the effect of altitude changes to the controller. This display will be used in the future to perform a human-in-the-loop experiment to assess the benefits of including altitude information in the 2D SSD ATCO displays.
7. Discussion
The SSD represents the spaces of velocity vectors that are conflict free. The remaining conflict areas were used as an indication of the level of difficulty that a controller has to handle. When conflict zones in the SSD occupy more area, fewer possible solutions are available to resolve future separation violations. The capability of SSD area properties in measuring the dynamic behavior of the sector was proven in previous studies [23,24]. The ongoing research is aimed at understanding the possibility of using the SSD in investigating the effects of various sector design properties on complexity and controller workload.
Based on the results gathered from the simulations, the complexity measure of intercept angle, aircraft speed, horizontal proximity, the number of aircraft, and the effect of aircraft orientation can be illustrated through the covered area percentage of the SSD. Each sector complexity factor is portrayed differently on the SSD. It is assumed that a denser area is related to a higher complexity measure. From the initial study conducted, it is concluded that a higher intercept angle, results in a smaller complexity metric, but also that this condition only applies if the observed aircraft has a route length larger or equal than the controlled aircraft. For horizontal proximity properties, it was found that further apart aircraft have a lower complexity metric. The effect of speed on the other hand depends on the position and intercept angle of the observed aircraft where a larger speed may result in higher or lower complexity metric. The number of aircraft within a sector also has a high implication on sector complexity and this was also portrayed in the SSD. However, the importance of the aircraft orientation was also an important characteristic that has an effect on the SSD area properties and thus, sector complexity.
However, it should be noted that these sector complexity parameters did not change individually at each instant, because of the dynamic behavior of the aircraft within the sector. As an initial stage of an investigation, this case study will provide the basis for hypotheses that will be tested systematically in subsequent studies. To further understand the behavior of the SSD it is important to investigate other and more combinations of sector complexity metrics. In future studies, the findings regarding the relationship between sector complexity factors and SSD metrics should be validated by means of human-in-the-loop experiments to also get the ATCO’s insight on the perceived workload and how this can be related to the sector complexity mapped on the SSD.
\n',keywords:null,chapterPDFUrl:"https://cdn.intechopen.com/pdfs/38068.pdf",chapterXML:"https://mts.intechopen.com/source/xml/38068.xml",downloadPdfUrl:"/chapter/pdf-download/38068",previewPdfUrl:"/chapter/pdf-preview/38068",totalDownloads:2511,totalViews:186,totalCrossrefCites:1,totalDimensionsCites:2,totalAltmetricsMentions:0,impactScore:1,impactScorePercentile:71,impactScoreQuartile:3,hasAltmetrics:0,dateSubmitted:"December 13th 2011",dateReviewed:"April 4th 2012",datePrePublished:null,datePublished:"August 1st 2012",dateFinished:"July 26th 2012",readingETA:"0",abstract:null,reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/38068",risUrl:"/chapter/ris/38068",book:{id:"2181",slug:"advances-in-air-navigation-services"},signatures:"S.M.B. Abdul Rahman, C. Borst, M. Mulder and M.M. van Paassen",authors:[{id:"10586",title:"Prof.",name:"Max",middleName:null,surname:"Mulder",fullName:"Max Mulder",slug:"max-mulder",email:"m.mulder@tudelft.nl",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/10586/images/1739_n.jpg",institution:{name:"Delft University of Technology",institutionURL:null,country:{name:"Netherlands"}}},{id:"10843",title:"Dr.",name:"Marinus M.",middleName:null,surname:"Van Paassen",fullName:"Marinus M. Van Paassen",slug:"marinus-m.-van-paassen",email:"m.m.vanpaassen@tudelft.nl",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"147658",title:"MSc.",name:"Siti Mariam",middleName:null,surname:"Abdul Rahman",fullName:"Siti Mariam Abdul Rahman",slug:"siti-mariam-abdul-rahman",email:"s.m.b.abdulrahman@tudelft.nl",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"153742",title:"Dr.",name:"Clark",middleName:null,surname:"Borst",fullName:"Clark Borst",slug:"clark-borst",email:"c.borst@tudelft.nl",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Sector complexity and workload ",level:"1"},{id:"sec_2_2",title:"2.1. Previous research on complexity factors ",level:"2"},{id:"sec_2_3",title:"2.1.1. Static density",level:"3"},{id:"sec_3_3",title:"2.1.2. Dynamic density",level:"3"},{id:"sec_4_3",title:"2.1.3. Solution space-based approach",level:"3"},{id:"sec_7",title:"3. Complexity measure using the solution space diagram",level:"1"},{id:"sec_8",title:"4. Sector complexity variables ",level:"1"},{id:"sec_8_2",title:"4.1. Horizontal proximity ",level:"2"},{id:"sec_9_2",title:"4.2. Speed variations",level:"2"},{id:"sec_10_2",title:"4.3. Intercept angle ",level:"2"},{id:"sec_10_3",title:"4.3.1. Front side and backside crossings",level:"3"},{id:"sec_11_3",title:"4.3.2. Time to conflict",level:"3"},{id:"sec_13_2",title:"4.4. Number of aircraft and aircraft orientation ",level:"2"},{id:"sec_15",title:"5. Solution space diagram in measuring workload",level:"1"},{id:"sec_16",title:"6. Future research",level:"1"},{id:"sec_17",title:"7. Discussion",level:"1"}],chapterReferences:[{id:"B1",body:'HilburnB. G.JornaP. G. A. 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1. Introduction
Since 4500 BC, breath-holding dives for mother-of-pearl, sea sponges, and coral was a distinct occupation. These free divers could hold their breath for extended periods of time, and their work was confined to waters less than 30 m (100 ft) deep. It was undoubtedly a hazardous occupation, and many of them succumbed to decompression sickness after rapid surfacing. Persian king Xerxes the Great (520–465 BC) employed divers to salvage sunken goods and treasures from the wrecks of Greek ships he had sunk in numerous battles at sea. Some of these dives were recorded to depths of 20–30 m and lasting 4 minutes at a time. The ancient Greek historians Herodotos and Pausanias wrote about a Greek hero named Scyllias from Scione, who used a reed and diving capsule made from animal skins to cut the mooring lines of enemy ships. Pausanias even taught his own daughter Hydna to dive. Alexander the Great (365–323 BC), under the advice of a reputed astronomer named Ethicus, dived into the Bosphorus straits in a bathysphere, accompanied by a dog, a cat, and a rooster, after entrusting the security of the hoisting chain to his most loyal mistress. Taking advantage of the moment, she chose to elope with her lover after casting the chain into the sea, abandoning Alexander and leaving him to figure out his escape on his own! In 300 BC, Aristotle described the ruptured eardrum as a complication of undersea diving.
While living in Venice in the late fifteenth century, Leonardo da Vinci designed diving suits to enable divers cut holes in the hulls of invading ships, but none seem to have been developed or used [1].
In 1620, Dutch inventor Cornelis Jacobszoon Drebbel (1572–1633) designed a wooden diving boat, sealed against water by greased leather, to travel in the River Thames at a depth of around 4 m, from Westminster to Greenwich. Air was supplied by two tubes with floats to maintain one end above water [2]. In sixteenth century England and France, full diving suits made of leather were used to depths of 60 ft with air being pumped down from the surface with the aid of manual pumps.
The first documented use of hyperbaric therapy was in 1662, when a British clergyman and physician named Nathaniel Henshaw used a system of organ bellows with unidirectional valves to change the atmospheric pressure in a sealed chamber called a domicilium (Figure 1). Without any scientific rationale whatsoever, Henshaw claimed that high air pressures would remedy acute conditions while lower pressures would yield salutary results in chronic disorders. His domicilium therapy was touted to improve digestion and prevent lung diseases by manipulating ambient pressures without increasing oxygen concentrations, as oxygen was not discovered until nearly a century later [2].
Figure 1.
Henshaw and his domicilium.
In 1690, Edmond Halley designed a diving bell ventilated with weighted barrels of air sent down from the surface. Employing this device, Halley, escorted by five of his close friends, undertook a dive to a depth of 60 ft in the River Thames in that bell and remained submerged at that depth for 90 minutes. Too heavy for salvage work, Halley made improvements to his bell, extending his underwater exposure time to over 4 hours. The first deep-sea diving suit was invented in 1819 by Augustus Siebe. It used compressed air supplied to the helmet for ease of movement underwater.
All of these early submersibles used ambient air and were called “pneumatic chambers” or “compressed air baths.”
2. The era of empirical HBOT/HBO spas
Nearly two centuries later, in the 1830s, there was a rebirth of interest in hyperbaric medicine in France. In 1834, the French physician Junod built a hyperbaric chamber designed by the steam engine inventor James Watt, who was well-versed in pressure physics. This appliance could generate a maximum of 4 atmospheres pressure and used to treat pulmonary afflictions using pressures between 2 and 4 ATA. Junod referred to his treatment as “Le Bain d’air com-primé” (the compressed air bath), and claimed that it increased circulation to the internal organs and the brain, resulting in feelings of well-being and better general health.
Taberie designed a spherical pneumatic chamber made of cast iron with two pipes, one to provide pressure from a hydraulic compressor run by steam and the other to allow for ventilation. Carpet covered the floor to conceal the pipes, and it featured an antechamber to allow the physician to enter and exit without disturbing the pressure. The passage was also used to stock books, newspapers, and drinks for the patients (Figure 2).
Figure 2.
Taberie’s pneumatic chamber.
Lange had a cylindrical chamber constructed out of wrought iron, designed to accommodate four persons. The temperature of the compressed air within the chamber was lowered in two ways. The first employed a stream of cold water directed against the force pump and the supply pipes. The second method was by filling a cup-shaped space at the top of the chamber with cold water and allowing it to cascade down the sides to soak sheets of linen and cool the air by evaporation. In winter the chamber was kept at a comfortable temperature by heating. The chamber was also provided with a device for regulating the flow of the incoming air so that it entered in a steady stream (instead of a succession of puffs in earlier versions) by a force pump. The pressure was secured, as in Tabarie’s system, by regulating the inflow and outflow of the air (Figure 3).
Figure 3.
Lange’s pneumatic chamber.
Leibig’s pneumatic chamber was located at Dianabad in Reichenhall, Bavaria, Germany. This pneumatic chamber had three chambers, each one capable of accommodating three persons. One antechamber connected all three rooms, allowing the physician to enter and exit without affecting the ambient pressure. The antechamber also acted as a large pressure regulator, preventing the patients from being affected by sudden surges of pressure. A ventilation pipe through an opening in the ceiling provided good ventilation (Figure 4). The temperature and pressures within each chamber could also be individually controlled [3].
Figure 4.
Leibig’s pneumatic chamber.
In 1837, Pravaz built the largest hyperbaric chamber in Lyon, France, to seat 12 patients and treat patients with pulmonary conditions including tuberculosis, laryngitis, tracheitis, and pertussis, as well as unrelated conditions such as cholera, conjunctivitis, deafness, menorrhagia, and rickets. In 1855, Bertin wrote a book on compressed air therapy and even constructed his own hyperbaric chamber.
Compressed air therapy was first introduced into the USA by JL Corning in 1871. In 1876, Kelly treated a patient in a “Compressed Air Bath Apparatus” having two locking plates operated from outside to seal pressures. In 1877, French surgeon Fontaine developed the first mobile hyperbaric operating theater. The high ambient pressure was claimed to facilitate the reduction of hernias and provide relief for patients with lung diseases. Over the next 3 months, 27 surgeries were successfully performed within this mobile hyperbaric chamber (Figure 5). Spurred by the results, Fontaine ventured to erect a mammoth hyperbaric surgical amphitheater to accommodate 300 patients in one sitting. This did not see the light of day as Fontaine died from an accident at the Pneumatic Institute to become the first physician to be martyred in the history of hyperbaric medicine [4].
Figure 5.
Fontaine’s mobile hyperbaric operation theater.
In 1885, C Theodore Williams published his “Lectures on the Compressed Air Bath and its Uses in the Treatment of Disease” in the British Medical Journal, extolling the use of atmospheric air under different degrees of atmospheric pressure to treat diseases. He remarked that this mode of therapy was among the most important advances in modern medicine and expressed astonishment at its being ignored in England [5].
Back in the USA, during the closing days of the World War I, Kansas-bavsed physician Orval J Cunningham built a hyperbaric chamber in 1921 at Lawrence, Kansas. He used the facility to treat victims of the Spanish influenza epidemic that swept North America. Noticing that people in the valley fared better than those living in the mountains, Cunningham theorized that atmospheric pressure or barometric factors were responsible for the higher mortality rates in those residing at higher elevations. He observed remarkable improvements in patients treated with HBO, especially those who were cyanotic and comatose. In 1923, heat from open gas burners warming the chambers in winter scorched the insulation and started a fire, but all patients were safely evacuated. In another incident, a mechanical failure caused a complete loss of pressure within the chamber and all patients died. This did not, however, deter Cunningham’s enthusiasm for hyperbaric air. He went on to treat diseases such as syphilis, hypertension, diabetes mellitus, and cancer, believing that anaerobic infections played a role in the etiology of all these afflictions. In 1928, with the financial backing of Henry H. Timken, a roller bearing manufacturer and tycoon, Cunningham built the largest hyperbaric chamber in the world along the shores of Lake Erie in Cleveland, Ohio, at a cost of 1 million dollars. This “Steel Ball Hospital” or “Cunningham’s Sanitarium” was a five-story high steel sphere, 64 ft in diameter with 60 rooms and weighing 900 tons. Each floor of this structure had 12 rooms, with all the amenities of a good hotel (Figures 6 and 7). The growing popularity of Cunningham’s treatments prompted the Bureau of Investigation of the American Medical Association (AMA) to request the doctor to validate his claims regarding the effectiveness of hyperbaric therapy. Cunningham refused to share the details or cooperate with the AMA, leading to his being labeled a quack and a fraud. The chamber was dismantled in 1937 and sold for scrap during World War II [6].
Figure 6.
Cunningham’s hyperbaric hotel—outside and inside view.
Figure 7.
Cunningham’s hyperbaric hotel—exterior and interior views.
3. A historical account of decompression sickness and its treatment
In 1840, Charles Pasley, charged with the recovery of the sunken warship HMS Royal George, commented that, of those who made frequent dives, “not a man escaped the repeated attacks of rheumatism and cold.” In 1841, Trigger, a French mining engineer, used a pressure chamber to deliver workers to the bottom of the river to extract coal. In 1845, he reported that some of his miners complained of joint pains and nervous disorders after surfacing. The first recorded death from “caisson disease” (which later came to be known as decompression illness (DCI) or acute decompression sickness) occurred in 1859 during the building of the Royal Albert Bridge, a railway bridge in England spanning the River Tamar from Saltash to Plymouth. Several workers were taken ill after emerging from deep underground after long hours of work under high atmospheric pressure conditions. In 1871, during the construction of the Eads Bridge in St. Louis, 352 compressed air workers, including Alphonse Jaminet, the physician in charge, were employed. Thirty workers developed serious conditions with 12 ending fatally. Jaminet himself suffered decompression sickness, and his personal description was the first such recorded. It was in 1873 that Andrew Smith first utilized the term “caisson disease” to describe 110 cases of decompression sickness that occurred during construction of the Brooklyn Bridge. The project employed 600 compressed air workers, and recompression treatment was not available on site. In 1882, during the Hudson tunnel construction in New York, every fourth worker died of bends until a recompression chamber was installed to treat the condition. Only three workers died of bends over the next 18 months.
Paul Bert, a French professor of physiology and a student of Claude Bernard, is considered the father of pressure physiology (Figure 8). In 1878, while working closely with Dr. Alphonse Gal, the first doctor to actually dive in order to study how the body reacted underwater, Bert studied Gal’s reports on divers who became symptomatic or died while surfacing. He conducted a series of dog experiments, exposing them to 7–9¾ atmospheres and subjecting them to rapid decompression. A majority of them died and exhibited grossly distended bodies with their right heart chambers filled with gas. When decompression was done at slowly over 1–2 hours after exposure to similar pressures, none of the dogs succumbed. Applying Dalton’s and Henry’s gas laws, Bert concluded that too rapid a decompression induced a pathophysiologic insult secondary to supersaturation of body tissues with nitrogen, causing the formation of nitrogen bubbles. He also went on to suggest that divers stop halfway to the surface to allow for slow decompression after a deep dive—what is now known as deep stops. Bert was also the first to describe oxygen toxicity at pressures in excess of 1.75 ATA. This adverse effect on the central nervous system came to be known as the “Paul Bert effect” [7, 8].
Figure 8.
Dr. Paul Bert (1883–1886).
In 1908, Scottish physiologist John Scott Haldane conducted experiments at the Lister Institute of Preventive Medicine in London assisted by Lieutenant Guybon Damant of the Royal Navy, an expert diver and amateur scientist, and a physiologist Edwin Arthur Boycott. A herd of 85 goats was assembled, and the researchers put groups of up to eight goats inside compression chambers for specific periods of time. Pressures were then normalized before releasing the animals into the institute’s yard for observation. These studies confirmed that those goats decompressed by stages did not exhibit signs of the bends (Figure 9). Haldane then introduced the concept of half times—the time required for a particular tissue to become half saturated with a gas—and recommended staged decompression, especially at shallower depths. He prepared detailed practical dive tables for the Royal Navy to prevent acute decompression sickness. These guidelines remained the foundation of all diving operations until 1956 [10]. Heinrich Drager was the first to explore the use of pressurized oxygen in decompression sickness (Figure 10). His protocols were put into practice by Behnke and Shaw, who used HBOT for treating decompression sickness in the late 1930s. They replaced oxygen in place of compressed air, and their work resulted in the use of the first nitrogen-oxygen mixtures and hyperbaric treatment being tailored to the severity of the injury [11]. In 1939, the US Navy began treating divers suffering decompression sickness with hyperbaric oxygen therapy. After World War II, the US military conducted extensive research in HBOT, and this expanded the existing knowledge about survivable pressures and popularized HBOT in the late 1950s and early 1960s. In the 1980s, Paul Harch began an in-depth study of brain decompression illness (DCI) and evaluated divers with this disorder. He concluded that it was not residual gas that was being treated but ischemic brain injury. He went on to develop individualized treatment protocols for over 50 different chronic neurological disorders. Harch is considered to be the foremost authority in the use of HBOT and SPECT brain blood flow imaging in neurology [12, 13, 14]. In 1990, former microbiology professor Igor Gamow invented and patented the Gamow Bag that provided mountaineers with a mobile and effective method to treat high-altitude sickness. This bag is a single-place portable hyperbaric chamber, pressurized with a foot pump, to simulate a descent to 7000 ft (Figure 11). In 1992, Harch treated the first delayed decompression sickness, which led to the treating of “dementia pugilistica” in boxers and cerebral palsy and autism in children [15].
Figure 9.
Bends in the foreleg of a goat after experiments performed by physiologist Haldane [9].
Figure 10.
Drager and his recompression chamber.
Figure 11.
The Gamow Bag.
4. Treating diseases with HBO
In 1937, Brazilians Ozorio de Almeida and Costa pioneered the use of HBOT in treating leprosy [16]. In the 1950s, Ite Boerema, a cardiac surgeon from the Netherlands, conceived the idea of “flooding” the body’s tissues with extra oxygen. Working with the help of the Royal Dutch Navy, Boerema conducted a series of animal experiments and operations within a hyperbaric oxygen chamber (Figure 12). These went off without a hitch and led to the installation of a large operating hyperbaric chamber at the University of Amsterdam. Many children with congenital heart diseases like tetralogy of Fallot, transposition of great vessels, and pulmonic stenosis were operated in this facility with great success. Boerema mooted the concept of “Life without blood” using HBO, when dissolved oxygen sufficed to meet the entire body’s oxygen needs without the need for red cells or hemoglobin. Boerema is credited with being the father of modern-day hyperbaric medicine [17].
Figure 12.
Dr. Boerema with children operated by him.
In 1955–1956, I Churchill-Davidson evaluated clinical trials on HBOT as a potentiator for radiation therapy in cancer patients at St. Thomas Hospital in London [18]. Public interest in hyperbaric oxygen therapy started to grow in the 1960s after publicity about its use in treating President John F Kennedy’s sick infant. In 1961, a colleague of Boerema, W. H. Brummelkamp, published a paper on inhibition of anaerobic infections by HBOT [19]. In 1962, Smith and Sharp reported the enormous benefits of HBO in carbon monoxide poisoning. They recommended that all those having a verified carboxyhemoglobin level above 25% needed immediate HBOT at 3 ATA for 90 minutes, followed by two or three more sessions for full recovery, making HBO very cost-effective [20]. Global interest in HBOT was rekindled by this finding, resulting in hyperbaric units being installed at many centers like Duke University, New York Mount Sinai Hospital, Presbyterian Hospital and Edgeworth Hospital in Chicago, Good Samaritan in Los Angeles, St. Barnabas Hospital in New Jersey, Harvard Children’s Hospital, and St. Luke’s Hospital in Milwaukee. In 1965, Perrins from the UK demonstrated the effectiveness of HBOT in osteomyelitis [21]. In 1966, Saltzman and coworkers from the USA proved the effectiveness of HBOT in stroke patients [22].
In 1970, Boschetty and Cernoch of Czechoslovakia conducted a trial of HBOT for multiple sclerosis. In their series 15 out of 26 patients with multiple sclerosis showed improvement after HBOT at 2 atmospheres [23]. In 1971, Lamm of West Germany used HBOT for treatment of sudden deafness. It was shown that HBOT shortens the course of healing in high-pitch perception dysacusis by upregulating constitutive nitric oxide synthase in the substructure of the cochlea [24]. In 1973, Thurston pioneered studies that showed lower mortality figures in patients with myocardial infarction treated with HBO. HBOT was shown to improve oxygen supply to the threatened heart and reduce the volume of infarct size and other major adverse outcomes [25]. In 1972, Richard A Neubauer set up the Ocean Hyperbaric Neurologic Center in Lauderdale-by-the-Sea exclusively for HBOT in the management of various central nervous system disorders. He mooted the concept of “idling” neurons capable of surviving for years or even decades after the original injury. He claimed that these injured neurons could be re-activated with HBOT and that the greater the number of idling neurons, the better would be the patient’s response to HBOT [26]. Neubauer was also the co-founder and executive director of the American College of Hyperbaric Medicine. After his death in 2007 at the age of 83, his clinical research center in Florida was renamed the Neubauer Hyperbaric Neurologic Center. In 1976, Hollbach and Wasserman determined that 1.5 ATA (atmospheres absolute) maximizes oxygen content and glucose metabolism in the brain [27].
In 1985, RE Marx and his colleagues observed that the rate of osteoradionecrosis was 30%/patient in patients treated with penicillin alone while rates in those treated with HBO was only 5% [28]. In 1987, Jain successfully treated patients with paralytic stroke using HBOT [29, 30]. In 2002, a US Army study confirmed that HBOT repairs white matter damage in children with cerebral palsy. In 2005, Stoller of the USA treated the first case of a child with fetal alcohol syndrome using HBOT and with good outcome [31]. In 2006, Thom of the USA discovered that HBO causes stem cell mobilization [32]. In 2010, Godman discovered that HBOT activated 8101 genes, resulting in reduction of inflammation and increase in growth in body tissues [33, 34]. In 2011, Stoller treated the first retired National Football League (NFL) player for chronic traumatic encephalopathy [35]. In 2012, Harch and his colleagues demonstrated that blast-induced post-concussion syndrome and post-traumatic stress disorders responded to HBOT [15].
The UHMS and FDA approved HBOT for treatment of conditions like autism, stroke, air embolism, ischemic limbs, split-thickness skin graft acceptance, failed grafts, flap survival and salvage, wound reepithelialization, acute thermal burns, etc. (Table 1) [36, 37].
Clostridial myositis and myonecrosis (gas gangrene)
Crush injuries, compartment syndromes, and other acute traumatic peripheral ischemias
Decompression sickness
Enhancement of healing in selected problem wounds
Exceptional blood loss anemia
Intracranial abscess
Necrotizing soft tissue infections
Refractory osteomyelitis
Skin flaps and grafts (compromised)
Delayed radiation injury (soft tissue and bony necrosis)
Thermal burns
Table 1.
UHMS- and FDA-approved indications for hyperbaric oxygen therapy.
Many patients do not respond to aggressive acid-suppressing medications. HBOT has a beneficial effect in patients with blunt duodenal trauma, duodenal ulcers, and indomethacin-/radiation-induced gastritis. This salubrious effect is mediated by decreased production of oxidative stress markers like tumor necrosis factor-alpha, interleukin-1beta, neopterin, myeloperoxidase, and malondialdehyde. HBOT is seen to improve the acid-neutralizing function of the stomach, normalize gastric motility, reduce the duodenum acidification, decrease edema, and improve the blood flow both in human and equine studies [38, 39]. These effects were also seen in cases of inflammatory bowel diseases like Crohn’s [40].
5. Landmark academic events in HBOT
In September 1961, the First International Congress on the clinical applications of hyperbaric oxygen was held in Amsterdam. The Second International Conference on HBO was held in Glasgow in September 1964, with detailed deliberations on various aspects of HBOT. In November 1965, the Third International Congress on HBOT was organized at the Duke University at Durham, North Carolina. The Fourth and Fifth International Congresses were held in Sapporo, Japan, and Vancouver, respectively, in 1969 and 1973. The University of Aberdeen, Scotland, hosted the sixth conference in August 1977. The subsequent International Congress was held in Moscow in 1981 and is an annual event thereafter. The deliberations during these academic forums threw fresh light on the basic physiology, oxygen toxicity, and therapeutic applications of HBO in human disease.
The Undersea Medical Society (it added hyperbaric to its name in 1986), an organization made up largely of naval and ex-navy physicians, was founded in 1967 in the USA. It reviewed the indiscriminate and inappropriate use of the HBO chamber for a variety of medical conditions by practitioners searching for a “cure-all” therapy, tarnishing the credibility of hyperbaric medicine. This nonprofit organization, now known as the Undersea and Hyperbaric Medical Society (UHMS), set up a Committee on Hyperbaric Oxygen Therapy in the 1970s to systematically review all the available scientific evidence for HBOT and formulate absolute indications for HBOT. This was accepted by insurance providers, including Medicare. The UHMS is committed to providing, promoting, developing, and raising the quality of care across the spectrum in scientific communication, life sciences, and clinical practices of hyperbaric medicine by promoting high standards of patient care and operational safety. It offers accreditation and certificate of competency and credibility and has over 2500 members in 50 countries. UHMS also awards board certification in Undersea and Hyperbaric Medicine through the American Board of Emergency Medicine (ABEM), the American Board of Preventive Medicine (ABPM), and fellowship training in Undersea and Hyperbaric Medicine.
In 1980, Dr. Richard A. Neubauer and Dr. William S. Maxfield formed the American College of Hyperbaric Medicine (ACHM) to foster the ethical advancement and expansion of hyperbaric medicine. The International Society of Hyperbaric Medicine was founded in 1988.
Hyperbaric medicine was approved by the American Board of Medical Specialties as a sub-specialty of emergency and preventative medicine in 2000.
6. Developments in HBOT chambers
In 1860, the first hyperbaric chamber in the North American continent was constructed in Oshawa, Ontario, Canada. A year later, a neurologist, James Leonard Corning, built the first hyperbaric chamber in the USA in New York. This chamber was used to treat “nervous and related disorders.” The first decompression chamber was invented by the Italian engineer Alberto Gianni in 1916 [39, 40]. In 1928, the Harvard Medical School built a hyperbaric chamber for medical research. Among the largest HBOT chambers is the 22 ton 32 ft wide 14 ft wide one at the Utah Valley Regional Medical Center, USA.
In modern times, many traditional hard-shell hyperbaric chambers and soft-shell, portable hyperbaric chambers (Figures 13–18) are manufactured by several companies and available in every major city. The latest chambers must comply with NFPA-992012 Edition Chapter 14 Code in the USA and European 1997 CEN pressure vessels 97/23E standards as well as the 1998 ECHM recommendations for safety. The newer chambers feature hingeless pressure-sealed doors, antifriction bearings, antibacterial leather upholstery, and high-quality resin fiber loop mattresses and pillows that dissipate heat and moisture generated by the body during therapy. The newer low-pressure monoplace chambers are portable and less expensive. Operating between 1.2 and 1.3 ATA pressures, they are eminently suited for use in homes and spas and also find use to improve results after plastic surgery.
Figure 13.
The evolution of hyperbaric chambers.
Figure 14.
Monoplace HBO chamber.
Figure 15.
Recompression chamber.
Figure 16.
Multiplace HBOT chamber.
Figure 17.
Hyperbaric operation suite.
Figure 18.
Hyperbaric operation suite. (Image courtesy: CONE Health Wound Care and Hyperbaric Center, Greensboro, North Carolina, USA).
The earliest documentation of therapeutic use of HBOT in animals was in 1998. The Veterinary Hyperbaric Medicine Society was formed in 2006. Veterinary-specific hyperbaric chambers are available.
The evolution of HBOT chambers over time is chronicled in Figure 13.
7. Current status of HBOT
HBOT was called the Cinderella of modern medicine since it was not taught in medical schools and had no pharmaceutical companies to nurture and protect it. Over the course of time, it has shed the label of being a mysterious therapy and become a major tool in the armamentarium of clinicians either as a primary or adjunctive therapy for a spectrum of diseases. Stroke, cancer, heart disease, and chronic lung disease account for almost 60% of the total number of deaths. Hypoxia is a significant component of the pathology of these conditions, and this leads to metabolic acidosis, organ dysfunction, and death. Conventional oxygen therapy may not have desired results, when HBOT yields remarkable clinical improvement. HBOT prevents 75 percent of all major amputations that would otherwise be necessary for diabetic wounds and a 450% increase in complete recovery in patients with traumatic brain injury receiving HBOT vs. standard intensive care. Newer application of HBOT is in emergency care for resuscitation in cases of acute blood loss, near drowning, hanging and poisoning, and cardiorespiratory arrest.
Athletic associations like the NFL employ hyperbaric oxygen therapy as part of the recovery regimen for its athletes, and some players own their own HBOT chambers. Joe Namath experienced remarkable recovery from the head injuries he sustained during his career, leading him to be part of an FDA-approved study of HBOT at the Joe Namath Neurological Center of the Jupiter Medical Center in Florida. Ace swimmer Michael Phelps and football stars Maurice Jones-Drew and James Harrison have endorsed the benefits of HBOT, along with professional boxers like Evander Holyfield [41].
8. Conclusions
With the utilization of isotopic tracers, magnetic resonance imaging (MRI), and single-photon emission computed tomography (SPECT), HBOT is getting evidence-based recognition. Various conditions like brain injuries, stroke, and neurological diseases with poor prognosis are now amenable to improved outcomes with the application of HBOT. There are more than 500 hyperbaric facilities in the USA alone. Much research remains to be done regarding the efficacy of HBO2 therapy to develop treatment plans for those in extremes of age. The use of hyperbaric medicine to treat wounds in the foot or in the brain is a divine gift, and great advances in this field are on the horizon. The future of healthcare is here!
\n',keywords:"history, hyperbaric oxygen therapy",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/66258.pdf",chapterXML:"https://mts.intechopen.com/source/xml/66258.xml",downloadPdfUrl:"/chapter/pdf-download/66258",previewPdfUrl:"/chapter/pdf-preview/66258",totalDownloads:1536,totalViews:0,totalCrossrefCites:0,dateSubmitted:"December 3rd 2018",dateReviewed:"February 14th 2019",datePrePublished:"April 18th 2019",datePublished:"October 28th 2020",dateFinished:"March 21st 2019",readingETA:"0",abstract:"The history of hyperbaric oxygen therapy (HBOT) makes for fascinating reading. From pneumatic chambers and compressed air baths to empirical therapeutic applications during the nineteenth century, the impetus to scientific application of HBOT began in seeking solution for decompression sickness during various construction ventures. French physiologist Paul Bert’s research was pathbreaking and provided a scientific explanation on the etiology of the “bends.” In 1908, JS Haldane’s experiments recommended staged decompression and made diving safe. In 1921, OJ Cunningham employed HBOT to treat hypoxia secondary to lung infections successfully. It was cardiac surgeon Ite Boerema who put HBOT on a solid footing with his open-heart surgery results in various pediatric cardiac conditions and rightly deserved the title of father of modern-day hyperbaric medicine. From 1937 onwards, HBOT research snowballed into treating a wide variety of diseases. In 1999, the Undersea and Hyperbaric Medical Society and Food and Drug Administration recognized the value of HBOT, and this led to its becoming a major tool in the armamentarium of clinicians, either as a primary or adjunctive therapy for a spectrum of diseases.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/66258",risUrl:"/chapter/ris/66258",signatures:"Chandrasekhar Krishnamurti",book:{id:"9126",type:"book",title:"Respiratory Physiology",subtitle:null,fullTitle:"Respiratory Physiology",slug:"respiratory-physiology",publishedDate:"October 28th 2020",bookSignature:"Ketevan Nemsadze",coverURL:"https://cdn.intechopen.com/books/images_new/9126.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:"978-1-83962-326-4",printIsbn:"978-1-83962-325-7",pdfIsbn:"978-1-83962-327-1",isAvailableForWebshopOrdering:!0,editors:[{id:"149748",title:"Dr.",name:"Ketevan",middleName:null,surname:"Nemsadze",slug:"ketevan-nemsadze",fullName:"Ketevan Nemsadze"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"257885",title:"Dr.",name:"Chandrasekhar",middleName:null,surname:"Krishnamurti",fullName:"Chandrasekhar Krishnamurti",slug:"chandrasekhar-krishnamurti",email:"globeshaker@gmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. The era of empirical HBOT/HBO spas",level:"1"},{id:"sec_3",title:"3. A historical account of decompression sickness and its treatment",level:"1"},{id:"sec_4",title:"4. Treating diseases with HBO",level:"1"},{id:"sec_5",title:"5. Landmark academic events in HBOT",level:"1"},{id:"sec_6",title:"6. Developments in HBOT chambers",level:"1"},{id:"sec_7",title:"7. Current status of HBOT",level:"1"},{id:"sec_8",title:"8. Conclusions",level:"1"}],chapterReferences:[{id:"B1",body:'History of Hyperbaric Oxygen Therapy, Richmond Hyperbaric Health Centre. www.richmond-hyperbaric.com'},{id:"B2",body:'Jain KK. Textbook of Hyperbaric Medicine. 4th ed. Hogrefe & Huber: Ashland, OH; 2004'},{id:"B3",body:'Tissier PLA. In: Cohen SS, editor. Pneumotherapy: Including Aerotherapy and Inhalation Methods. Vol. X. Philadelphia: P. Blakiston’s Sons and Co; 1903'},{id:"B4",body:'Stewart J Jr, Corning JL. Exploring the History of Hyperbaric Chambers, Atmospheric Diving Suits and Manned Submersibles: The Scientists and Machinery. Bloomington, IN: Xlibris; 2011. p. 68. Available from: http://bit.ly/1o6LZhU [Accessed: 14 May 2014]'},{id:"B5",body:'Theodore Williams C. Lectures on the compressed air bath and its uses in the treatment of disease. British Medical Journal. 1885;1268(1):769-772'},{id:"B6",body:'Choffin M. The Cunningham Sanitarium, Cleveland Historical. Available from: https://clevelandhistorical.org/items/show/378 [Accessed: 31 January 2019]'},{id:"B7",body:'History of Hyperbaric Medicine and HBOT. hbot.g7oz.org'},{id:"B8",body:'Bert P. La Pression Barométrique, Recherches de Physiologie Expérimentale (1878), Barometric Pressure: Researches in Experimental Physiology; 1943'},{id:"B9",body:'Haldane JS. Journal of Hygiene: Cambridge University Press. 1908;8(2)'},{id:"B10",body:'Sekhar KC, Chakra Rao SSC, Haldane JS. The father of oxygen therapy. Indian Journal of Anaesthesia. 2014;58(3):350-352'},{id:"B11",body:'Clark D. History of hyperbaric therapy. In: Neuman TS, Thom SR, editors. Physiology and Medicine of Hyperbaric Oxygen Therapy. 1st ed. Philadelphia, PA: Saunders; 2008. pp. 3-18'},{id:"B12",body:'Harch PG, Neubauer RA. Hyperbaric oxygen therapy in global cerebral ischemia/anoxia and coma. In: Jain KK, editor. Chapter 19, Textbook of Hyperbaric Medicine. 5th Revised ed. Seattle, WA: Hogrefe and Huber Publishers; 2009. pp. 235-274'},{id:"B13",body:'Harch PG, Neubauer RA. Hyperbaric oxygen therapy in global cerebral ischemia/ anoxia and coma. In: Jain KK, editor. Chapter 18, Textbook of Hyperbaric Medicine. 3rd Revised ed. Seattle, WA: Hogrefe and Huber Publishers; 2004. pp. 223-261'},{id:"B14",body:'Harch PG, Neubauer RA, Uszler JM, James PB. Appendix: Diagnostic imaging and HBO therapy. In: Jain KK, editor. Chapter 44, Textbook of Hyperbaric Medicine. 5th Revised ed. Seattle, WA: Hogrefe and Huber Publishers; 2009. pp. 505-519'},{id:"B15",body:'Harch PG, Fogarty EF, Staab PF, van Meter K. Low pressure hyperbaric oxygen therapy and SPECT brain imaging in the treatment of blast-induced chronic traumatic brain injury (post-concussion syndrome) and post traumatic stress disorder: A case report. Cases Journal. 2009;2:6538'},{id:"B16",body:'De Alemeida AO, Rabello E. Dermatological Society, National Academy of Medicine of Rio de Janeiro; 1937'},{id:"B17",body:'Leopardi LN, Metcalfe MS, Fortde A, et al. Ite Boerema—Surgeon and engineer with a double-Dutch legacy to medical technology. Surgery. 2004;135(1):99-103'},{id:"B18",body:'Neubauer RA, Maxfield WS. The polemics of hyperbaric medicine. Journal of the American Physicians and Surgeons. 2005;10:15-17'},{id:"B19",body:'Brummelkamp WH, Hogendijk L, Boerema I. Treatment of anaerobic infections (Clostridial myositis) by drenching the tissues with oxygen under high atmospheric pressure. Surgery. 1961;49:299-302'},{id:"B20",body:'Smith G, Sharp GR. Treatment of carbon-monoxide poisoning with oxygen under pressure. Lancet. 1960;276:905-906'},{id:"B21",body:'Perrins JD, Maudsley RH, Colwill MW, Slack WK. Thomas DAOHP in the management of chronic osteomyelitis. In: Brown IW, Cox BG, editors. Proceedings of the Third International Conference on Hyperbaric Medicine. Washington, DC: National Academy of Sciences, National Research Council; 1966. pp. 578-584'},{id:"B22",body:'Saltzman HA, Heyman A, Whalen RE. The use of hyperbaric oxygen in the treatment of cerebral ischemia and infarction. Circulation. 1966;33 & 34(Supplement II):II-20-II-27'},{id:"B23",body:'Boschetty V, Cernoch J. Aplikace kysliku za pretlaku a nekterych neurologickych onemocneni. Vol. 53. 1980. pp. 687-690'},{id:"B24",body:'Lamm K, Lamm H, Arnold W. Effect of hyperbaric oxygen therapy in comparison to conventional or placebo therapy or no treatment in idiopathic sudden hearing loss, acoustic trauma, noise-induced hearing loss and tinnitus. A literature survey. Advances in Oto-Rhino-Laryngology. 1998;54:86-99'},{id:"B25",body:'Thurston GJ, Greenwood TW, Bending MR, Connor H, Curwen MP. A controlled investigation into the effects of hyperbaric oxygen on mortality following acute myocardial infarction. Quarterly Journal of Medicine. 1973;XLII:751-770'},{id:"B26",body:'Neubauer RA, Gottlieb SF, Kagan RL. Enhancing “idling” neurons. Lancet. 1990;335:542'},{id:"B27",body:'Holbach KH, Caroli A, Wassmann H. Cerebral energy metabolism in patients with brain lesions of normo- and hyperbaric oxygen pressures. Journal of Neurology. 1977;217(1):17-30'},{id:"B28",body:'Marx RE, Johnson RP, Kline SN. Prevention of osteoradionecrosis: A randomized prospective clinical trial of hyperbaric oxygen versus penicillin. Journal of the American Dental Association. 1985;111(1):49-54'},{id:"B29",body:'Jain KK. Hyperbaric oxygen in acute ischemic stroke. Stroke. 2003;34(2):571-574'},{id:"B30",body:'Jain KK. Role of hyperbaric oxygenation in the management of stroke. In: Jain KK, editor. Textbook of Hyperbaric Medicine. 3rd ed. Göttingen, Germany: Hogrefe & Huber; 2003'},{id:"B31",body:'Stoller KP. Quantification of neurocognitive changes before, during, and after hyperbaric oxygen therapy in a case of fetal alcohol syndrome. Pediatrics. 2005;116:e586-e591'},{id:"B32",body:'Thom SR, Bhopale VM, Velazquez OC, et al. Stem cell mobilization by hyperbaric oxygen. American Journal of Physiology. Heart and Circulatory Physiology. 2006;290:H1378-H1386'},{id:"B33",body:'Godman C, Chheda K, Hightower L, Perdrizet G, Shin D-G, Giardina C. Hyperbaric oxygen induces a cytoprotective and angiogenic response in human microvascular endothelial cells. Cell Stress & Chaperones. 2010;15:431-442'},{id:"B34",body:'Godman CA, Joshi R, Giardina C, Perdrizet G, Hightower LE. Hyperbaric oxygen treatment induces antioxidant gene expression. Annals of the New York Academy of Sciences. 2010;1197:178-183'},{id:"B35",body:'Stoller KP. Hyperbaric oxygen therapy (1.5 ATA) in treating sports related TBI/CTE: Two case reports. Medical Gas Research. 2011;1:17'},{id:"B36",body:'Hampson NB, editor. Hyperbaric Oxygen Therapy: 1999 Committee Report. Kensington, MD: Undersea and Hyperbaric Medical Society; 1999'},{id:"B37",body:'Gesell LB, editor. Hyperbaric Oxygen Therapy Indications. The Hyperbaric Oxygen Therapy Committee Report. 12th ed. Durham, NC: Undersea and Hyperbaric Medical Society; 2008'},{id:"B38",body:'Güneş AE, Gözeneli O, Akal A, Taşkın A, Sezen H, Güldür ME. An experimental study on the effectiveness of hyperbaric oxygen and thymoquinone treatment in blunt duodenal injury. Konuralp Tıp Dergisi. 2018;10(3):347-353'},{id:"B39",body:'Yang Z, Nandi J, Wang J, Bosco G, et al. Hyperbaric oxygenation ameliorates indomethacin-induced enteropathy in rats by modulating TNF-α and IL-1β production. Digestive Diseases and Sciences. 2006;51(8):1427-1433'},{id:"B40",body:'Rossignol DA. Hyperbaric oxygen treatment for inflammatory bowel disease: A systematic review and analysis. Medical Gas Research. 2012;2:6'},{id:"B41",body:'Kindwall EP. A history of hyperbaric medicine. In: Hyperbaric Medicine Practice. 3rd ed. Flagstaff, AZ: Best Publishing; 2008. pp. 3-22'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Chandrasekhar Krishnamurti",address:"globeshaker@gmail.com",affiliation:'
Department of Anesthesiology, NRI Institute of Medical Sciences, Visakhapatnam, Andhra Pradesh, India
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The company was founded in Vienna in 2004 by Alex Lazinica and Vedran Kordic, two PhD students researching robotics. While completing our PhDs, we found it difficult to access the research we needed. So, we decided to create a new Open Access publisher. A better one, where researchers like us could find the information they needed easily. The result is IntechOpen, an Open Access publisher that puts the academic needs of the researchers before the business interests of publishers.
",metaTitle:"Our story",metaDescription:"The company was founded in Vienna in 2004 by Alex Lazinica and Vedran Kordic, two PhD students researching robotics. While completing our PhDs, we found it difficult to access the research we needed. So, we decided to create a new Open Access publisher. A better one, where researchers like us could find the information they needed easily. The result is IntechOpen, an Open Access publisher that puts the academic needs of the researchers before the business interests of publishers.",metaKeywords:null,canonicalURL:"/page/our-story",contentRaw:'[{"type":"htmlEditorComponent","content":"
We started by publishing journals and books from the fields of science we were most familiar with - AI, robotics, manufacturing and operations research. Through our growing network of institutions and authors, we soon expanded into related fields like environmental engineering, nanotechnology, computer science, renewable energy and electrical engineering, Today, we are the world’s largest Open Access publisher of scientific research, with over 4,200 books and 54,000 scientific works including peer-reviewed content from more than 116,000 scientists spanning 161 countries. Our authors range from globally-renowned Nobel Prize winners to up-and-coming researchers at the cutting edge of scientific discovery.
\\n\\n
In the same year that IntechOpen was founded, we launched what was at the time the first ever Open Access, peer-reviewed journal in its field: the International Journal of Advanced Robotic Systems (IJARS).
\\n\\n
The IntechOpen timeline
\\n\\n
2004
\\n\\n
\\n\\t
Intech Open is founded in Vienna, Austria, by Alex Lazinica and Vedran Kordic, two PhD students, and their first Open Access journals and books are published.
\\n\\t
Alex and Vedran launch the first Open Access, peer-reviewed robotics journal and IntechOpen’s flagship publication, the International Journal of Advanced Robotic Systems (IJARS).
\\n
\\n\\n
2005
\\n\\n
\\n\\t
IntechOpen publishes its first Open Access book: Cutting Edge Robotics.
\\n
\\n\\n
2006
\\n\\n
\\n\\t
IntechOpen publishes a special issue of IJARS, featuring contributions from NASA scientists regarding the Mars Exploration Rover missions.
\\n
\\n\\n
2008
\\n\\n
\\n\\t
Downloads milestone: 200,000 downloads reached
\\n
\\n\\n
2009
\\n\\n
\\n\\t
Publishing milestone: the first 100 Open Access STM books are published
\\n
\\n\\n
2010
\\n\\n
\\n\\t
Downloads milestone: one million downloads reached
\\n\\t
IntechOpen expands its book publishing into a new field: medicine.
\\n
\\n\\n
2011
\\n\\n
\\n\\t
Publishing milestone: More than five million downloads reached
\\n\\t
IntechOpen publishes 1996 Nobel Prize in Chemistry winner Harold W. Kroto’s “Strategies to Successfully Cross-Link Carbon Nanotubes”. Find it here.
\\n\\t
IntechOpen and TBI collaborate on a project to explore the changing needs of researchers and the evolving ways that they discover, publish and exchange information. The result is the survey “Author Attitudes Towards Open Access Publishing: A Market Research Program”.
\\n\\t
IntechOpen hosts SHOW - Share Open Access Worldwide; a series of lectures, debates, round-tables and events to bring people together in discussion of open source principles, intellectual property, content licensing innovations, remixed and shared culture and free knowledge.
\\n
\\n\\n
2012
\\n\\n
\\n\\t
Publishing milestone: 10 million downloads reached
\\n\\t
IntechOpen holds Interact2012, a free series of workshops held by figureheads of the scientific community including Professor Hiroshi Ishiguro, director of the Intelligent Robotics Laboratory, who took the audience through some of the most impressive human-robot interactions observed in his lab.
\\n
\\n\\n
2013
\\n\\n
\\n\\t
IntechOpen joins the Committee on Publication Ethics (COPE) as part of a commitment to guaranteeing the highest standards of publishing.
\\n
\\n\\n
2014
\\n\\n
\\n\\t
IntechOpen turns 10, with more than 30 million downloads to date.
\\n\\t
IntechOpen appoints its first Regional Representatives - members of the team situated around the world dedicated to increasing the visibility of our authors’ published work within their local scientific communities.
\\n
\\n\\n
2015
\\n\\n
\\n\\t
Downloads milestone: More than 70 million downloads reached, more than doubling since the previous year.
\\n\\t
Publishing milestone: IntechOpen publishes its 2,500th book and 40,000th Open Access chapter, reaching 20,000 citations in Thomson Reuters ISI Web of Science.
\\n\\t
40 IntechOpen authors are included in the top one per cent of the world’s most-cited researchers.
\\n\\t
Thomson Reuters’ ISI Web of Science Book Citation Index begins indexing IntechOpen’s books in its database.
\\n
\\n\\n
2016
\\n\\n
\\n\\t
IntechOpen is identified as a world leader in Simba Information’s Open Access Book Publishing 2016-2020 report and forecast. IntechOpen came in as the world’s largest Open Access book publisher by title count.
\\n
\\n\\n
2017
\\n\\n
\\n\\t
Downloads milestone: IntechOpen reaches more than 100 million downloads
\\n\\t
Publishing milestone: IntechOpen publishes its 3,000th Open Access book, making it the largest Open Access book collection in the world
We started by publishing journals and books from the fields of science we were most familiar with - AI, robotics, manufacturing and operations research. Through our growing network of institutions and authors, we soon expanded into related fields like environmental engineering, nanotechnology, computer science, renewable energy and electrical engineering, Today, we are the world’s largest Open Access publisher of scientific research, with over 4,200 books and 54,000 scientific works including peer-reviewed content from more than 116,000 scientists spanning 161 countries. Our authors range from globally-renowned Nobel Prize winners to up-and-coming researchers at the cutting edge of scientific discovery.
\n\n
In the same year that IntechOpen was founded, we launched what was at the time the first ever Open Access, peer-reviewed journal in its field: the International Journal of Advanced Robotic Systems (IJARS).
\n\n
The IntechOpen timeline
\n\n
2004
\n\n
\n\t
Intech Open is founded in Vienna, Austria, by Alex Lazinica and Vedran Kordic, two PhD students, and their first Open Access journals and books are published.
\n\t
Alex and Vedran launch the first Open Access, peer-reviewed robotics journal and IntechOpen’s flagship publication, the International Journal of Advanced Robotic Systems (IJARS).
\n
\n\n
2005
\n\n
\n\t
IntechOpen publishes its first Open Access book: Cutting Edge Robotics.
\n
\n\n
2006
\n\n
\n\t
IntechOpen publishes a special issue of IJARS, featuring contributions from NASA scientists regarding the Mars Exploration Rover missions.
\n
\n\n
2008
\n\n
\n\t
Downloads milestone: 200,000 downloads reached
\n
\n\n
2009
\n\n
\n\t
Publishing milestone: the first 100 Open Access STM books are published
\n
\n\n
2010
\n\n
\n\t
Downloads milestone: one million downloads reached
\n\t
IntechOpen expands its book publishing into a new field: medicine.
\n
\n\n
2011
\n\n
\n\t
Publishing milestone: More than five million downloads reached
\n\t
IntechOpen publishes 1996 Nobel Prize in Chemistry winner Harold W. Kroto’s “Strategies to Successfully Cross-Link Carbon Nanotubes”. Find it here.
\n\t
IntechOpen and TBI collaborate on a project to explore the changing needs of researchers and the evolving ways that they discover, publish and exchange information. The result is the survey “Author Attitudes Towards Open Access Publishing: A Market Research Program”.
\n\t
IntechOpen hosts SHOW - Share Open Access Worldwide; a series of lectures, debates, round-tables and events to bring people together in discussion of open source principles, intellectual property, content licensing innovations, remixed and shared culture and free knowledge.
\n
\n\n
2012
\n\n
\n\t
Publishing milestone: 10 million downloads reached
\n\t
IntechOpen holds Interact2012, a free series of workshops held by figureheads of the scientific community including Professor Hiroshi Ishiguro, director of the Intelligent Robotics Laboratory, who took the audience through some of the most impressive human-robot interactions observed in his lab.
\n
\n\n
2013
\n\n
\n\t
IntechOpen joins the Committee on Publication Ethics (COPE) as part of a commitment to guaranteeing the highest standards of publishing.
\n
\n\n
2014
\n\n
\n\t
IntechOpen turns 10, with more than 30 million downloads to date.
\n\t
IntechOpen appoints its first Regional Representatives - members of the team situated around the world dedicated to increasing the visibility of our authors’ published work within their local scientific communities.
\n
\n\n
2015
\n\n
\n\t
Downloads milestone: More than 70 million downloads reached, more than doubling since the previous year.
\n\t
Publishing milestone: IntechOpen publishes its 2,500th book and 40,000th Open Access chapter, reaching 20,000 citations in Thomson Reuters ISI Web of Science.
\n\t
40 IntechOpen authors are included in the top one per cent of the world’s most-cited researchers.
\n\t
Thomson Reuters’ ISI Web of Science Book Citation Index begins indexing IntechOpen’s books in its database.
\n
\n\n
2016
\n\n
\n\t
IntechOpen is identified as a world leader in Simba Information’s Open Access Book Publishing 2016-2020 report and forecast. IntechOpen came in as the world’s largest Open Access book publisher by title count.
\n
\n\n
2017
\n\n
\n\t
Downloads milestone: IntechOpen reaches more than 100 million downloads
\n\t
Publishing milestone: IntechOpen publishes its 3,000th Open Access book, making it the largest Open Access book collection in the world
\n
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He received his Ph.D. in Molecular Biology with his thesis “Genetic variability of the tick-borne encephalitis virus in natural foci of Novosibirsk city and its suburbs.” His primary field is molecular virology with research emphasis on vector-borne viruses, especially tick-borne encephalitis virus, Kemerovo virus and Omsk hemorrhagic fever virus, rabies virus, molecular genetics, biology, and epidemiology of virus pathogens.",institutionString:"Russian Academy of Sciences",institution:{name:"Russian Academy of Sciences",country:{name:"Russia"}}},{id:"310962",title:"Dr.",name:"Amlan",middleName:"Kumar",surname:"Patra",slug:"amlan-patra",fullName:"Amlan Patra",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/310962/images/system/310962.jpg",biography:"Amlan K. Patra, FRSB, obtained a Ph.D. in Animal Nutrition from Indian Veterinary Research Institute, India, in 2002. He is currently an associate professor at West Bengal University of Animal and Fishery Sciences. He has more than twenty years of research and teaching experience. He held previous positions at the American Institute for Goat Research, The Ohio State University, Columbus, USA, and Free University of Berlin, Germany. His research focuses on animal nutrition, particularly ruminants and poultry nutrition, gastrointestinal electrophysiology, meta-analysis and modeling in nutrition, and livestock–environment interaction. He has authored around 175 articles in journals, book chapters, and proceedings. Dr. Patra serves on the editorial boards of several reputed journals.",institutionString:null,institution:{name:"West Bengal University of Animal and Fishery Sciences",country:{name:"India"}}},{id:"53998",title:"Prof.",name:"László",middleName:null,surname:"Babinszky",slug:"laszlo-babinszky",fullName:"László Babinszky",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/53998/images/system/53998.png",biography:"László Babinszky is Professor Emeritus, Department of Animal Nutrition Physiology, University of Debrecen, Hungary. He has also worked in the Department of Animal Nutrition, University of Wageningen, Netherlands; the Institute for Livestock Feeding and Nutrition (IVVO), Lelystad, Netherlands; the Agricultural University of Vienna (BOKU); the Institute for Animal Breeding and Nutrition, Austria; and the Oscar Kellner Research Institute for Animal Nutrition, Rostock, Germany. In 1992, Dr. Babinszky obtained a Ph.D. in Animal Nutrition from the University of Wageningen. His main research areas are swine and poultry nutrition. He has authored more than 300 publications (papers, book chapters) and edited four books and fourteen international conference proceedings.",institutionString:"University of Debrecen",institution:{name:"University of Debrecen",country:{name:"Hungary"}}},{id:"201830",title:"Dr.",name:"Fernando",middleName:"Sanchez",surname:"Davila",slug:"fernando-davila",fullName:"Fernando Davila",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/201830/images/5017_n.jpg",biography:"I am a professor at UANL since 1988. My research lines are the development of reproductive techniques in small ruminants. We also conducted research on sexual and social behavior in males.\nI am Mexican and study my professional career as an engineer in agriculture and animal science at UANL. Then take a masters degree in science in Germany (Animal breeding). Take a doctorate in animal science at the UANL.",institutionString:null,institution:{name:"Universidad Autónoma de Nuevo León",country:{name:"Mexico"}}},{id:"309250",title:"Dr.",name:"Miguel",middleName:null,surname:"Quaresma",slug:"miguel-quaresma",fullName:"Miguel Quaresma",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/309250/images/9059_n.jpg",biography:"Miguel Nuno Pinheiro Quaresma was born on May 26, 1974 in Dili, Timor Island. He is married with two children: a boy and a girl, and he is a resident in Vila Real, Portugal. He graduated in Veterinary Medicine in August 1998 and obtained his Ph.D. degree in Veterinary Sciences -Clinical Area in February 2015, both from the University of Trás-os-Montes e Alto Douro. He is currently enrolled in the Alternative Residency of the European College of Animal Reproduction. He works as a Senior Clinician at the Veterinary Teaching Hospital of UTAD (HVUTAD) with a role in clinical activity in the area of livestock and equine species as well as to support teaching and research in related areas. He teaches as an Invited Professor in Reproduction Medicine I and II of the Master\\'s in Veterinary Medicine degree at UTAD. Currently, he holds the position of Chairman of the Portuguese Buiatrics Association. He is a member of the Consultive Group on Production Animals of the OMV. He has 19 publications in indexed international journals (ISIS), as well as over 60 publications and oral presentations in both Portuguese and international journals and congresses.",institutionString:"University of Trás-os-Montes and Alto Douro",institution:{name:"University of Trás-os-Montes and Alto Douro",country:{name:"Portugal"}}},{id:"38652",title:"Prof.",name:"Rita",middleName:null,surname:"Payan-Carreira",slug:"rita-payan-carreira",fullName:"Rita Payan-Carreira",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRiFPQA0/Profile_Picture_1614601496313",biography:"Rita Payan Carreira earned her Veterinary Degree from the Faculty of Veterinary Medicine in Lisbon, Portugal, in 1985. She obtained her Ph.D. in Veterinary Sciences from the University of Trás-os-Montes e Alto Douro, Portugal. After almost 32 years of teaching at the University of Trás-os-Montes and Alto Douro, she recently moved to the University of Évora, Department of Veterinary Medicine, where she teaches in the field of Animal Reproduction and Clinics. Her primary research areas include the molecular markers of the endometrial cycle and the embryo–maternal interaction, including oxidative stress and the reproductive physiology and disorders of sexual development, besides the molecular determinants of male and female fertility. She often supervises students preparing their master's or doctoral theses. She is also a frequent referee for various journals.",institutionString:null,institution:{name:"University of Évora",country:{name:"Portugal"}}},{id:"283019",title:"Dr.",name:"Oudessa",middleName:null,surname:"Kerro Dego",slug:"oudessa-kerro-dego",fullName:"Oudessa Kerro Dego",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/283019/images/system/283019.png",biography:"Dr. Kerro Dego is a veterinary microbiologist with training in veterinary medicine, microbiology, and anatomic pathology. Dr. Kerro Dego is an assistant professor of dairy health in the department of animal science, the University of Tennessee, Institute of Agriculture, Knoxville, Tennessee. He received his D.V.M. (1997), M.S. (2002), and Ph.D. (2008) degrees in Veterinary Medicine, Animal Pathology and Veterinary Microbiology from College of Veterinary Medicine, Addis Ababa University, Ethiopia; College of Veterinary Medicine, Utrecht University, the Netherlands and Western College of Veterinary Medicine, University of Saskatchewan, Canada respectively. He did his Postdoctoral training in microbial pathogenesis (2009 - 2015) in the Department of Animal Science, the University of Tennessee, Institute of Agriculture, Knoxville, Tennessee. Dr. Kerro Dego’s research focuses on the prevention and control of infectious diseases of farm animals, particularly mastitis, improving dairy food safety, and mitigation of antimicrobial resistance. Dr. Kerro Dego has extensive experience in studying the pathogenesis of bacterial infections, identification of virulence factors, and vaccine development and efficacy testing against major bacterial mastitis pathogens. Dr. Kerro Dego conducted numerous controlled experimental and field vaccine efficacy studies, vaccination, and evaluation of immunological responses in several species of animals, including rodents (mice) and large animals (bovine and ovine).",institutionString:"University of Tennessee at Knoxville",institution:{name:"University of Tennessee at Knoxville",country:{name:"United States of America"}}},{id:"251314",title:"Dr.",name:"Juan Carlos",middleName:null,surname:"Gardón",slug:"juan-carlos-gardon",fullName:"Juan Carlos Gardón",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/251314/images/system/251314.jpeg",biography:"Juan Carlos Gardón Poggi received University degree from the Faculty of Agrarian Science in Argentina, in 1983. Also he received Masters Degree and PhD from Córdoba University, Spain. He is currently a Professor at the Catholic University of Valencia San Vicente Mártir, at the Department of Medicine and Animal Surgery. He teaches diverse courses in the field of Animal Reproduction and he is the Director of the Veterinary Farm. He also participates in academic postgraduate activities at the Veterinary Faculty of Murcia University, Spain. His research areas include animal physiology, physiology and biotechnology of reproduction either in males or females, the study of gametes under in vitro conditions and the use of ultrasound as a complement to physiological studies and development of applied biotechnologies. Routinely, he supervises students preparing their doctoral, master thesis or final degree projects.",institutionString:"Catholic University of Valencia San Vicente Mártir, Spain",institution:null},{id:"125292",title:"Dr.",name:"Katy",middleName:null,surname:"Satué Ambrojo",slug:"katy-satue-ambrojo",fullName:"Katy Satué Ambrojo",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/125292/images/system/125292.jpeg",biography:"Katy Satué Ambrojo received her Veterinary Medicine degree, Master degree in Equine Technology and doctorate in Veterinary Medicine from the Faculty of Veterinary, CEU-Cardenal Herrera University in Valencia, Spain. She is a Full Professor at the Department of Medicine and Animal Surgery at the same University. She developed her research activity in the field of Endocrinology, Hematology, Biochemistry and Immunology of horses. She is a scientific reviewer of several international journals : American Journal of Obstetrics and Gynecology, Comparative Clinical Pathology, Veterinary Clinical Pathology, Journal of Equine Veterinary Science, Reproduction in Domestic Animals, Research Veterinary Science, Brazilian Journal of Medical and Biological Research, Livestock Production Science and Theriogenology. Since 2014, she has been the Head of the Clinical Analysis Laboratory of the Hospital Clínico Veterinario from the Faculty of Veterinary, CEU-Cardenal Herrera University.",institutionString:"CEU-Cardenal Herrera University",institution:{name:"CEU Cardinal Herrera University",country:{name:"Spain"}}},{id:"309529",title:"Dr.",name:"Albert",middleName:null,surname:"Rizvanov",slug:"albert-rizvanov",fullName:"Albert Rizvanov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/309529/images/9189_n.jpg",biography:'Albert A. Rizvanov is a Professor and Director of the Center for Precision and Regenerative Medicine at the Institute of Fundamental Medicine and Biology, Kazan Federal University (KFU), Russia. He is the Head of the Center of Excellence “Regenerative Medicine” and Vice-Director of Strategic Academic Unit \\"Translational 7P Medicine\\". Albert completed his Ph.D. at the University of Nevada, Reno, USA and Dr.Sci. at KFU. He is a corresponding member of the Tatarstan Academy of Sciences, Russian Federation. Albert is an author of more than 300 peer-reviewed journal articles and 22 patents. He has supervised 11 Ph.D. and 2 Dr.Sci. dissertations. Albert is the Head of the Dissertation Committee on Biochemistry, Microbiology, and Genetics at KFU.\nORCID https://orcid.org/0000-0002-9427-5739\nWebsite https://kpfu.ru/Albert.Rizvanov?p_lang=2',institutionString:"Kazan Federal University",institution:{name:"Kazan Federal University",country:{name:"Russia"}}},{id:"210551",title:"Dr.",name:"Arbab",middleName:null,surname:"Sikandar",slug:"arbab-sikandar",fullName:"Arbab Sikandar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/210551/images/system/210551.jpg",biography:"Dr. Arbab Sikandar, PhD, M. Phil, DVM was born on April 05, 1981. He is currently working at the College of Veterinary & Animal Sciences as an Assistant Professor. He previously worked as a lecturer at the same University. \nHe is a Member/Secretory of Ethics committee (No. CVAS-9377 dated 18-04-18), Member of the QEC committee CVAS, Jhang (Regr/Gen/69/873, dated 26-10-2017), Member, Board of studies of Department of Basic Sciences (No. CVAS. 2851 Dated. 12-04-13, and No. CVAS, 9024 dated 20/11/17), Member of Academic Committee, CVAS, Jhang (No. CVAS/2004, Dated, 25-08-12), Member of the technical committee (No. CVAS/ 4085, dated 20,03, 2010 till 2016).\n\nDr. Arbab Sikandar contributed in five days hands-on-training on Histopathology at the Department of Pathology, UVAS from 12-16 June 2017. He received a Certificate of appreciation for contributions for Popularization of Science and Technology in the Society on 17-11-15. He was the resource person in the lecture series- ‘scientific writing’ at the Department of Anatomy and Histology, UVAS, Lahore on 29th October 2015. He won a full fellowship as a principal candidate for the year 2015 in the field of Agriculture, EICA, Egypt with ref. to the Notification No. 12(11) ACS/Egypt/2014 from 10 July 2015 to 25th September 2015.; he received a grant of Rs. 55000/- as research incentives from Director, Advanced Studies and Research, UVAS, Lahore upon publications of research papers in IF Journals (DR/215, dated 19-5-2014.. He obtained his PhD by winning a HEC Pakistan indigenous Scholarship, ‘Ph.D. fellowship for 5000 scholars – Phase II’ (2av1-147), 17-6/HEC/HRD/IS-II/12, November 15, 2012. \n\nDr. Sikandar is a member of numerous societies: Registered Veterinary Medical Practitioner (life member) and Registered Veterinary Medical Faculty of Pakistan Veterinary Medical Council. The Registration code of PVMC is RVMP/4298 and RVMF/ 0102.; Life member of the University of Veterinary and Animal Sciences, Lahore, Alumni Association with S# 664, dated: 6-4-12. ; Member 'Vets Care Organization Pakistan” with Reference No. VCO-605-149, dated 05-04-06. :Member 'Vet Crescent” (Society of Animal Health and Production), UVAS, Lahore.",institutionString:"University of Veterinary & Animal Science",institution:{name:"University of Veterinary and Animal Sciences",country:{name:"Pakistan"}}},{id:"311663",title:"Dr.",name:"Prasanna",middleName:null,surname:"Pal",slug:"prasanna-pal",fullName:"Prasanna Pal",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/311663/images/13261_n.jpg",biography:null,institutionString:null,institution:{name:"National Dairy Research Institute",country:{name:"India"}}},{id:"202192",title:"Dr.",name:"Catrin",middleName:null,surname:"Rutland",slug:"catrin-rutland",fullName:"Catrin Rutland",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",biography:"Catrin Rutland is an Associate Professor of Anatomy and Developmental Genetics at the University of Nottingham, UK. She obtained a BSc from the University of Derby, England, a master’s degree from Technische Universität München, Germany, and a Ph.D. from the University of Nottingham. She undertook a post-doctoral research fellowship in the School of Medicine before accepting tenure in Veterinary Medicine and Science. Dr. Rutland also obtained an MMedSci (Medical Education) and a Postgraduate Certificate in Higher Education (PGCHE). She is the author of more than sixty peer-reviewed journal articles, twelve books/book chapters, and more than 100 research abstracts in cardiovascular biology and oncology. She is a board member of the European Association of Veterinary Anatomists, Fellow of the Anatomical Society, and Senior Fellow of the Higher Education Academy. 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Samir worked as a member of different local projects on E-learning and he is a board member of the African Association of Veterinary Anatomists and of anatomy societies and as an associated author at local and international journals. Orcid: https://orcid.org/0000-0002-6180-389X",institutionString:null,institution:{name:"Alexandria University",country:{name:"Egypt"}}},{id:"246149",title:"Dr.",name:"Valentina",middleName:null,surname:"Kubale",slug:"valentina-kubale",fullName:"Valentina Kubale",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246149/images/system/246149.jpg",biography:"Valentina Kubale is Associate Professor of Veterinary Medicine at the Veterinary Faculty, University of Ljubljana, Slovenia. Since graduating from the Veterinary faculty she obtained her PhD in 2007, performed collaboration with the Department of Pharmacology, University of Copenhagen, Denmark. She continued as a post-doctoral fellow at the University of Copenhagen with a Lundbeck foundation fellowship. She is the editor of three books and author/coauthor of 23 articles in peer-reviewed scientific journals, 16 book chapters, and 68 communications at scientific congresses. Since 2008 she has been the Editor Assistant for the Slovenian Veterinary Research journal. 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Dr. Fonseca-Alves currently serves as an Assistant Professor at Paulista University – UNIP teaching small animal internal medicine.",institutionString:null,institution:{name:"Universidade Paulista",country:{name:"Brazil"}}},{id:"245306",title:"Dr.",name:"María Luz",middleName:null,surname:"Garcia Pardo",slug:"maria-luz-garcia-pardo",fullName:"María Luz Garcia Pardo",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/245306/images/system/245306.png",biography:"María de la Luz García Pardo is an agricultural engineer from Universitat Politècnica de València, Spain. She has a Ph.D. in Animal Genetics. Currently, she is a lecturer at the Agrofood Technology Department of Miguel Hernández University, Spain. Her research is focused on genetics and reproduction in rabbits. The major goal of her research is the genetics of litter size through novel methods such as selection by the environmental sensibility of litter size, with forays into the field of animal welfare by analysing the impact on the susceptibility to diseases and stress of the does. Details of her publications can be found at https://orcid.org/0000-0001-9504-8290.",institutionString:null,institution:{name:"Miguel Hernandez University",country:{name:"Spain"}}},{id:"41319",title:"Prof.",name:"Lung-Kwang",middleName:null,surname:"Pan",slug:"lung-kwang-pan",fullName:"Lung-Kwang Pan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/41319/images/84_n.jpg",biography:null,institutionString:null,institution:null},{id:"201721",title:"Dr.",name:"Beatrice",middleName:null,surname:"Funiciello",slug:"beatrice-funiciello",fullName:"Beatrice Funiciello",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/201721/images/11089_n.jpg",biography:"Graduated from the University of Milan in 2011, my post-graduate education included CertAVP modules mainly on equines (dermatology and internal medicine) and a few on small animal (dermatology and anaesthesia) at the University of Liverpool. After a general CertAVP (2015) I gained the designated Certificate in Veterinary Dermatology (2017) after taking the synoptic examination and then applied for the RCVS ADvanced Practitioner status. After that, I completed the Postgraduate Diploma in Veterinary Professional Studies at the University of Liverpool (2018). My main area of work is cross-species veterinary dermatology.",institutionString:null,institution:null},{id:"291226",title:"Dr.",name:"Monica",middleName:null,surname:"Cassel",slug:"monica-cassel",fullName:"Monica Cassel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/291226/images/8232_n.jpg",biography:'Degree in Biological Sciences at the Federal University of Mato Grosso with scholarship for Scientific Initiation by FAPEMAT (2008/1) and CNPq (2008/2-2009/2): Project \\"Histological evidence of reproductive activity in lizards of the Manso region, Chapada dos Guimarães, Mato Grosso, Brazil\\". Master\\\'s degree in Ecology and Biodiversity Conservation at Federal University of Mato Grosso with a scholarship by CAPES/REUNI program: Project \\"Reproductive biology of Melanorivulus punctatus\\". PhD\\\'s degree in Science (Cell and Tissue Biology Area) \n at University of Sao Paulo with scholarship granted by FAPESP; Project \\"Development of morphofunctional changes in ovary of Astyanax altiparanae Garutti & Britski, 2000 (Teleostei, Characidae)\\". She has experience in Reproduction of vertebrates and Morphology, with emphasis in Cellular Biology and Histology. She is currently a teacher in the medium / technical level courses at IFMT-Alta Floresta, as well as in the Bachelor\\\'s degree in Animal Science and in the Bachelor\\\'s degree in Business.',institutionString:null,institution:null},{id:"442807",title:"Dr.",name:"Busani",middleName:null,surname:"Moyo",slug:"busani-moyo",fullName:"Busani Moyo",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Gwanda State University",country:{name:"Zimbabwe"}}},{id:"423023",title:"Dr.",name:"Yosra",middleName:null,surname:"Soltan",slug:"yosra-soltan",fullName:"Yosra Soltan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Alexandria University",country:{name:"Egypt"}}},{id:"349788",title:"Dr.",name:"Florencia Nery",middleName:null,surname:"Sompie",slug:"florencia-nery-sompie",fullName:"Florencia Nery Sompie",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Sam Ratulangi University",country:{name:"Indonesia"}}},{id:"345713",title:"Dr.",name:"Csaba",middleName:null,surname:"Szabó",slug:"csaba-szabo",fullName:"Csaba Szabó",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Debrecen",country:{name:"Hungary"}}},{id:"345719",title:"Mrs.",name:"Márta",middleName:null,surname:"Horváth",slug:"marta-horvath",fullName:"Márta Horváth",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Debrecen",country:{name:"Hungary"}}},{id:"420151",title:"Prof.",name:"Novirman",middleName:null,surname:"Jamarun",slug:"novirman-jamarun",fullName:"Novirman Jamarun",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Andalas University",country:{name:"Indonesia"}}},{id:"420149",title:"Dr.",name:"Rusmana",middleName:"Wijaya Setia",surname:"Wijaya Setia Ningrat",slug:"rusmana-wijaya-setia-ningrat",fullName:"Rusmana Wijaya Setia Ningrat",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Andalas University",country:{name:"Indonesia"}}},{id:"339759",title:"Mr.",name:"Abu",middleName:null,surname:"Macavoray",slug:"abu-macavoray",fullName:"Abu Macavoray",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Njala University",country:{name:"Sierra Leone"}}},{id:"339758",title:"Prof.",name:"Benjamin",middleName:null,surname:"Emikpe",slug:"benjamin-emikpe",fullName:"Benjamin Emikpe",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Ibadan",country:{name:"Nigeria"}}},{id:"339760",title:"Mr.",name:"Moinina Nelphson",middleName:null,surname:"Kallon",slug:"moinina-nelphson-kallon",fullName:"Moinina Nelphson Kallon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Njala University",country:{name:"Sierra Leone"}}}]}},subseries:{item:{id:"17",type:"subseries",title:"Metabolism",keywords:"Biomolecules Metabolism, Energy Metabolism, Metabolic Pathways, Key Metabolic Enzymes, Metabolic Adaptation",scope:"Metabolism is frequently defined in biochemistry textbooks as the overall process that allows living systems to acquire and use the free energy they need for their vital functions or the chemical processes that occur within a living organism to maintain life. Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. Thus all studies on metabolism will be considered for publication.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11413,editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",slug:"yannis-karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",biography:"Yannis Karamanos, born in Greece in 1953, completed his pre-graduate studies at the Université Pierre et Marie Curie, Paris, then his Masters and Doctoral degree at the Université de Lille (1983). He was associate professor at the University of Limoges (1987) before becoming full professor of biochemistry at the Université d’Artois (1996). He worked on the structure-function relationships of glycoconjugates and his main project was the investigations on the biological roles of the de-N-glycosylation enzymes (Endo-N-acetyl-β-D-glucosaminidase and peptide-N4-(N-acetyl-β-glucosaminyl) asparagine amidase). From 2002 he contributes to the understanding of the Blood-brain barrier functioning using proteomics approaches. He has published more than 70 papers. 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