\\n\\n
Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\\n\\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\\n"}]',published:!0,mainMedia:{caption:"Highly Cited",originalUrl:"/media/original/117"}},components:[{type:"htmlEditorComponent",content:'IntechOpen is proud to announce that 191 of our authors have made the Clarivate™ Highly Cited Researchers List for 2020, ranking them among the top 1% most-cited.
\n\nThroughout the years, the list has named a total of 261 IntechOpen authors as Highly Cited. Of those researchers, 69 have been featured on the list multiple times.
\n\n\n\nReleased this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\n\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"1719",leadTitle:null,fullTitle:"Genetic Manipulation of DNA and Protein - Examples from Current Research",title:"Genetic Manipulation of DNA and Protein",subtitle:"Examples from Current Research",reviewType:"peer-reviewed",abstract:"This diverse collection of research articles is united by the enormous power of modern molecular genetics. Every author accomplished two objectives: (1) making the field and the research described accessible to a large audience and (2) explaining fully the genetic tools and approaches that were used in the research. One fact stands out - the importance of a genetic approach to addressing a problem. I encourage you to read several chapters. You will feel the excitement of the scientists, and you will learn about an area of research with which you may not be familiar. Perhaps most importantly, you will understand the genetic approaches; and you will appreciate their importance to the research.",isbn:null,printIsbn:"978-953-51-0994-5",pdfIsbn:"978-953-51-5352-8",doi:"10.5772/2156",price:139,priceEur:155,priceUsd:179,slug:"genetic-manipulation-of-dna-and-protein-examples-from-current-research",numberOfPages:464,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"204480b394b0ba9a43580a1e04d53c50",bookSignature:"David Figurski",publishedDate:"February 5th 2013",coverURL:"https://cdn.intechopen.com/books/images_new/1719.jpg",numberOfDownloads:46597,numberOfWosCitations:22,numberOfCrossrefCitations:8,numberOfCrossrefCitationsByBook:2,numberOfDimensionsCitations:31,numberOfDimensionsCitationsByBook:2,hasAltmetrics:1,numberOfTotalCitations:61,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"April 27th 2011",dateEndSecondStepPublish:"May 25th 2011",dateEndThirdStepPublish:"September 29th 2011",dateEndFourthStepPublish:"October 29th 2011",dateEndFifthStepPublish:"February 28th 2012",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"104812",title:"Dr.",name:"David",middleName:null,surname:"Figurski",slug:"david-figurski",fullName:"David Figurski",profilePictureURL:"https://mts.intechopen.com/storage/users/104812/images/3761_n.png",biography:"David Figurski is Professor of Microbiology & Immunology at Columbia University, where he teaches molecular genetics. In 35 years at Columbia, he has mentored nineteen Ph.D. students and directed numerous postdoctoral scientists. His laboratory has been funded by the National Science Foundation, the American Cancer Society, and the National Institutes of Health. He has received awards for teaching and research and has given keynote lectures. Dr. Figurski was dean for the graduate students in the College of Physicians & Surgeons. He received his Ph.D. for work with Roger Christensen at the University of Rochester in New York. His postdoctoral work was at the University of California at San Diego with Donald Helinski. 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Vorgias",authors:[{id:"58442",title:"Prof.",name:"Constantinos",middleName:null,surname:"Vorgias",fullName:"Constantinos Vorgias",slug:"constantinos-vorgias"},{id:"58473",title:"Dr.",name:"Vassiliki",middleName:null,surname:"Pappa",fullName:"Vassiliki Pappa",slug:"vassiliki-pappa"},{id:"58579",title:"Dr.",name:"Effrossyni",middleName:null,surname:"Boutou",fullName:"Effrossyni Boutou",slug:"effrossyni-boutou"},{id:"58775",title:"Prof.",name:"Horst-Werner",middleName:null,surname:"Stuerzbecher",fullName:"Horst-Werner Stuerzbecher",slug:"horst-werner-stuerzbecher"}]},{id:"23148",title:"The Involvement of E2F1 in the Regulation of XRCC1-Dependent Base Excision DNA Repair",slug:"the-involvement-of-e2f1-in-the-regulation-of-xrcc1-dependent-base-excision-dna-repair",signatures:"Yulin Zhang and Dexi Chen",authors:[{id:"58196",title:"Prof.",name:"Dexi",middleName:null,surname:"Chen",fullName:"Dexi Chen",slug:"dexi-chen"},{id:"105721",title:"Dr.",name:"Yulin",middleName:null,surname:"Zhang",fullName:"Yulin Zhang",slug:"yulin-zhang"}]},{id:"23149",title:"Posttranslational Modifications of Rad51 Protein and Its Direct Partners: Role and Effect on Homologous Recombination – Mediated DNA Repair",slug:"posttranslational-modifications-of-rad51-protein-and-its-direct-partners-role-and-effect-on-homologo",signatures:"Milena Popova, Sébastien Henry and Fabrice Fleury",authors:[{id:"42982",title:"Prof.",name:"Fabrice",middleName:null,surname:"Fleury",fullName:"Fabrice Fleury",slug:"fabrice-fleury"},{id:"57791",title:"Dr.",name:"Milena",middleName:null,surname:"Popova",fullName:"Milena Popova",slug:"milena-popova"},{id:"57792",title:"Mr.",name:"Sébastien",middleName:null,surname:"Henry",fullName:"Sébastien Henry",slug:"sebastien-henry"}]},{id:"23150",title:"Post-Transcriptional Regulation of E2F Transcription Factors: Fine-Tuning DNA Repair, Cell Cycle Progression and Survival in Development & Disease",slug:"post-transcriptional-regulation-of-e2f-transcription-factors-fine-tuning-dna-repair-cell-cycle-progr",signatures:"Lina Dagnino, Randeep Kaur Singh and David Judah",authors:[{id:"46548",title:"Dr.",name:"Lina",middleName:null,surname:"Dagnino",fullName:"Lina Dagnino",slug:"lina-dagnino"},{id:"57591",title:"Ms.",name:"Randeep",middleName:null,surname:"Singh",fullName:"Randeep Singh",slug:"randeep-singh"},{id:"57592",title:"Mr.",name:"David",middleName:null,surname:"Judah",fullName:"David Judah",slug:"david-judah"}]},{id:"23151",title:"Eidetic Analysis of the Premature Chromosome Condensation Process",slug:"eidetic-analysis-of-the-premature-chromosome-condensation-process",signatures:"Dorota Rybaczek",authors:[{id:"40583",title:"Dr.",name:"Dorota",middleName:null,surname:"Rybaczek",fullName:"Dorota Rybaczek",slug:"dorota-rybaczek"}]},{id:"23152",title:"A DNA Repair Protein BRCA1 as a Potentially Molecular Target for the Anticancer Platinum Drug Cisplatin",slug:"a-dna-repair-protein-brca1-as-a-potentially-molecular-target-for-the-anticancer-platinum-drug-cispla",signatures:"Adisorn Ratanaphan",authors:[{id:"41290",title:"Dr.",name:"Adisorn",middleName:null,surname:"Ratanaphan",fullName:"Adisorn Ratanaphan",slug:"adisorn-ratanaphan"}]},{id:"23153",title:"Saccharomyces cerevisiae as a Model System to Study the Role of Human DDB2 in Chromatin Repair",slug:"saccharomyces-cerevisiae-as-a-model-system-to-study-the-role-of-human-ddb2-in-chromatin-repair",signatures:"Kristi L. Jones, Ling Zhang and Feng Gong",authors:[{id:"40853",title:"Prof.",name:"Feng",middleName:null,surname:"Gong",fullName:"Feng Gong",slug:"feng-gong"},{id:"40858",title:"Dr.",name:"Ling",middleName:null,surname:"Zhang",fullName:"Ling Zhang",slug:"ling-zhang"},{id:"93534",title:"Ms.",name:"Kristi",middleName:null,surname:"Jones",fullName:"Kristi Jones",slug:"kristi-jones"}]},{id:"23154",title:"Cell Cycle and DNA Damage Response in Postmitotic Neurons",slug:"cell-cycle-and-dna-damage-response-in-postmitotic-neurons",signatures:"Inna I. Kruman",authors:[{id:"40791",title:"Dr.",name:"Inna",middleName:null,surname:"Kruman",fullName:"Inna Kruman",slug:"inna-kruman"}]},{id:"23155",title:"TopBP1 in DNA Damage Response",slug:"topbp1-in-dna-damage-response",signatures:"Ewa Forma, Magdalena Brys and Wanda M. 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Brown",authors:[{id:"41145",title:"Dr.",name:"Erika",middleName:null,surname:"Brown",fullName:"Erika Brown",slug:"erika-brown"}]},{id:"23158",title:"Roles of MicroRNA in DNA Damage and Repair",slug:"roles-of-microrna-in-dna-damage-and-repair",signatures:"Xinrong Chen and Tao Chen",authors:[{id:"44557",title:"Dr.",name:"Tao",middleName:null,surname:"Chen",fullName:"Tao Chen",slug:"tao-chen"},{id:"44563",title:"Dr.",name:"Xinrong",middleName:null,surname:"Chen",fullName:"Xinrong Chen",slug:"xinrong-chen"}]},{id:"23159",title:"Meiosis as an Evolutionary Adaptation for DNA Repair",slug:"meiosis-as-an-evolutionary-adaptation-for-dna-repair",signatures:"Harris Bernstein, Carol Bernstein and Richard E. Michod",authors:[{id:"61946",title:"Dr.",name:"Carol",middleName:null,surname:"Bernstein",fullName:"Carol Bernstein",slug:"carol-bernstein"},{id:"61947",title:"Prof.",name:"Rick",middleName:null,surname:"Michod",fullName:"Rick Michod",slug:"rick-michod"},{id:"62025",title:"Dr.",name:"Carol",middleName:null,surname:"Bernstein",fullName:"Carol Bernstein",slug:"carol-bernstein"}]},{id:"23160",title:"From Seed to Tree: The Functioning and Evolution of DNA Repair in Plants",slug:"from-seed-to-tree-the-functioning-and-evolution-of-dna-repair-in-plants",signatures:"Jaana Vuosku, Marko Suokas, Johanna Kestilä, Tytti Sarjala and Hely Häggman",authors:[{id:"49286",title:"Dr.",name:"Jaana",middleName:null,surname:"Vuosku",fullName:"Jaana Vuosku",slug:"jaana-vuosku"},{id:"58305",title:"MSc.",name:"Marko",middleName:null,surname:"Suokas",fullName:"Marko Suokas",slug:"marko-suokas"},{id:"58306",title:"MSc.",name:"Johanna",middleName:null,surname:"Kestilä",fullName:"Johanna Kestilä",slug:"johanna-kestila"},{id:"58307",title:"Dr.",name:"Tytti",middleName:null,surname:"Sarjala",fullName:"Tytti Sarjala",slug:"tytti-sarjala"},{id:"58308",title:"Prof.",name:"Hely",middleName:null,surname:"Häggman",fullName:"Hely Häggman",slug:"hely-haggman"}]},{id:"23161",title:"The Gratuitous Repair on Undamaged DNA Misfold",slug:"the-gratuitous-repair-on-undamaged-dna-misfold",signatures:"Xuefeng Pan, Peng Xiao, Hongqun Li, Dongxu Zhao and Fei Duan",authors:[{id:"47738",title:"Prof.",name:"Xuefeng",middleName:null,surname:"Pan",fullName:"Xuefeng Pan",slug:"xuefeng-pan"}]},{id:"23162",title:"ATP-Binding Cassette Properties of Recombination Mediator Protein RecF",slug:"atp-binding-cassette-properties-of-recombination-mediator-protein-recf",signatures:"Sergey Korolev",authors:[{id:"42111",title:"Prof.",name:"Sergey",middleName:null,surname:"Korolev",fullName:"Sergey Korolev",slug:"sergey-korolev"}]},{id:"23163",title:"DNA Damage Recognition for Mammalian Global Genome Nucleotide Excision Repair",slug:"dna-damage-recognition-for-mammalian-global-genome-nucleotide-excision-repair",signatures:"Kaoru Sugasawa",authors:[{id:"51299",title:"Prof.",name:"Kaoru",middleName:null,surname:"Sugasawa",fullName:"Kaoru Sugasawa",slug:"kaoru-sugasawa"}]},{id:"23164",title:"DNA Double-Strand Break Repair Through Non-Homologous End-Joining: Recruitment and Assembly of the Players",slug:"dna-double-strand-break-repair-through-non-homologous-end-joining-recruitment-and-assembly-of-the-pl",signatures:"Radhika Pankaj Kamdar and Yoshihisa Matsumoto",authors:[{id:"42493",title:"Dr.",name:"Yoshihisa",middleName:null,surname:"Matsumoto",fullName:"Yoshihisa Matsumoto",slug:"yoshihisa-matsumoto"},{id:"57668",title:"Dr.",name:"Radhika Pankaj",middleName:null,surname:"Kamdar",fullName:"Radhika Pankaj Kamdar",slug:"radhika-pankaj-kamdar"}]},{id:"23165",title:"DNA Repair Capacity-Related to Genetic Polymorphisms of DNA Repair Genes and Aflatoxin B1-Related Hepatocellular Carcinoma Among Chinese Population",slug:"dna-repair-capacity-related-to-genetic-polymorphisms-of-dna-repair-genes-and-aflatoxin-b1-related-he",signatures:"Xi-Dai Long, Jin-Guang Yao, Zhi Zeng, Cen-Han Huang,\nPinhu Liao, Zan-Song Huang, Yong-Zhi Huang, Fu-Zhi Ban, Xiao-Yin Huang, Li-Min Yao, Lu-Dan Fan and Guo-Hui Fu",authors:[{id:"40527",title:"Dr.",name:"Xi-Dai",middleName:null,surname:"Long",fullName:"Xi-Dai Long",slug:"xi-dai-long"}]},{id:"23166",title:"Low Penetrance Genetic Variations in DNA Repair Genes and Cancer Susceptibility",slug:"low-penetrance-genetic-variations-in-dna-repair-genes-and-cancer-susceptibility",signatures:"Ravindran Ankathil",authors:[{id:"56743",title:"Prof.",name:"Ravindran",middleName:null,surname:"Ankathil",fullName:"Ravindran Ankathil",slug:"ravindran-ankathil"}]},{id:"23167",title:"Polymorphisms in Nucleotide Excision Repair Genes and Risk of Colorectal Cancer: A Systematic Review",slug:"polymorphisms-in-nucleotide-excision-repair-genes-and-risk-of-colorectal-cancer-a-systematic-review",signatures:"Rikke Dalgaard Hansen and Ulla Vogel",authors:[{id:"41763",title:"Prof.",name:"Ulla",middleName:null,surname:"Vogel",fullName:"Ulla Vogel",slug:"ulla-vogel"},{id:"49234",title:"Dr.",name:"Rikke Dalgaard",middleName:null,surname:"Hansen",fullName:"Rikke Dalgaard Hansen",slug:"rikke-dalgaard-hansen"}]},{id:"23168",title:"Variants and Polymorphisms of DNA Repair Genes and Neurodegenerative Diseases",slug:"variants-and-polymorphisms-of-dna-repair-genes-and-neurodegenerative-diseases",signatures:"Fabio Coppede",authors:[{id:"46639",title:"Dr.",name:"Fabio",middleName:null,surname:"Coppedè",fullName:"Fabio Coppedè",slug:"fabio-coppede"}]},{id:"23169",title:"Characterization of 5’-Flanking Regions of Various Human Telomere Maintenance Factor-Encoding Genes",slug:"characterization-of-5-flanking-regions-of-various-human-telomere-maintenance-factor-encoding-genes",signatures:"Fumiaki Uchiumi, Takahiro Oyama, Kensuke Ozaki and Sei-ichi Tanuma",authors:[{id:"47235",title:"Dr.",name:"Fumiaki",middleName:null,surname:"Uchiumi",fullName:"Fumiaki Uchiumi",slug:"fumiaki-uchiumi"},{id:"56770",title:"Mr.",name:"Takahiro",middleName:null,surname:"Oyama",fullName:"Takahiro Oyama",slug:"takahiro-oyama"},{id:"56771",title:"Dr.",name:"Sei-Ichi",middleName:null,surname:"Tanuma",fullName:"Sei-Ichi Tanuma",slug:"sei-ichi-tanuma"},{id:"91200",title:"BSc.",name:"Kensuke",middleName:null,surname:"Ozaki",fullName:"Kensuke Ozaki",slug:"kensuke-ozaki"}]},{id:"23170",title:"Roles of DNA Repair Proteins in Telomere Maintenance",slug:"roles-of-dna-repair-proteins-in-telomere-maintenance",signatures:"Masaru Ueno",authors:[{id:"41159",title:"Prof.",name:"Masaru",middleName:null,surname:"Ueno",fullName:"Masaru Ueno",slug:"masaru-ueno"}]},{id:"23171",title:"DNA Repair Measured by the Comet Assay",slug:"dna-repair-measured-by-the-comet-assay",signatures:"Amaya Azqueta, Sergey Shaposhnikov and Andrew R. Collins",authors:[{id:"47952",title:"Dr.",name:"Amaya",middleName:null,surname:"Azqueta",fullName:"Amaya Azqueta",slug:"amaya-azqueta"},{id:"57813",title:"Dr.",name:"Sergey",middleName:null,surname:"Shaposhnikov",fullName:"Sergey Shaposhnikov",slug:"sergey-shaposhnikov"},{id:"57814",title:"Prof.",name:"Andrew R",middleName:null,surname:"Collins",fullName:"Andrew R Collins",slug:"andrew-r-collins"}]}]}],publishedBooks:[{type:"book",id:"5784",title:"Antibody Engineering",subtitle:null,isOpenForSubmission:!1,hash:"2c8c3e133140fbc7f563918285e7c3c2",slug:"antibody-engineering",bookSignature:"Thomas Böldicke",coverURL:"https://cdn.intechopen.com/books/images_new/5784.jpg",editedByType:"Edited by",editors:[{id:"176804",title:"Dr.",name:"Thomas",surname:"Böldicke",slug:"thomas-boldicke",fullName:"Thomas Böldicke"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6435",title:"Gene 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Analysis",isOpenForSubmission:!1,hash:"f05d502dd643d2bd94344235d6e13199",slug:"biosensing-technologies-for-the-detection-of-pathogens-a-prospective-way-for-rapid-analysis",bookSignature:"Toonika Rinken and Kairi Kivirand",coverURL:"https://cdn.intechopen.com/books/images_new/6319.jpg",editedByType:"Edited by",editors:[{id:"24687",title:"Dr.",name:"Toonika",surname:"Rinken",slug:"toonika-rinken",fullName:"Toonika Rinken"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},onlineFirst:{chapter:{type:"chapter",id:"78118",title:"Perspective Chapter: Smart Maintenance in Modern Ship Engineering, Design and Operations",doi:"10.5772/intechopen.99027",slug:"perspective-chapter-smart-maintenance-in-modern-ship-engineering-design-and-operations",body:'The recent trend to design smart modern ships, more efficient with a high level of automation and processes control, this introduction of new technologies and changes in manning, requires from the Marine Engineers expertise to quickly solve the problems presented in the routine on board of modern merchant ships and oil rigs.
Marine Engineers are forged to face the most complex adversities of the maritime environment, whether in cabotage, maritime support, fluvial or on oil and gas rigs. Usually, the Marine Engineer is responsible for the production of potable water, lubricating oil and fuel system, sanitary and cooling system, propulsion system, electricity generation and others.
It is especially important to know the operating parameters of the systems and equipment, in order to give the correct diagnosis to his equipment and to know exactly which “medication” needs to be applied to solve the problem.
This chapter will use quality tools, the dart of Vasconcelos illustrated in Figure 1 [1] to quickly find the root cause of the problems. Troubleshooting is part of day-to-day job of an experienced Engineer.
Dart of Vasconcelos.
Troubleshooting can be defined as a logical search based on the symptomatic of a system or equipment, about what could be causing a particular problem, what would be its origin and how we could solve it to make the system or equipment operational again. One of the most important things to do an efficient troubleshooting is have a considerable knowledge from the subject in question, that can be obtained from the job experience and/or from a database (often from the system or equipment catalog itself) which provides a basis for the failure analysis that occurred.
Therefore, in summary, troubleshooting can be viewed as a careful way, which allows to accurately identify all the details of the system and, from that it is possible to make small changes in order to arrive at the root cause of the failure, as well as the to analyze each of the listed hypotheses to see if they can solve the problem effectively.
The basics steps of a good troubleshooting consist in identify the faced problem, establish a theory for the problem, test the theory, establish an action plan, and implement the solution. It is also possible to divide the troubleshooting sequence in define the problem through the
Symptomatic:
Example:
Main engine #02 running with low fuel oil pressure. Title could be: “
Logical Search:
Example:
Creating Hypotheses:
Dirty or blocked fuel filters on engine.
Dirty or blocked strainer for fuel feed pump.
Fuel injector problems.
Bad fuel conditions.
Fuel feed pump wrong internal gear installed.
Fuel feed pump with clearance in internal gear.
To solve the problem, is essential eliminate hypotheses.
Reducing Hypotheses:
Dirty or blocked fuel filters on engine. Not possible, once engine was running with a good fuel pressure before to be stopped for pump maintenance.
Dirty or blocked strainer for fuel feed pump. Not possible due fuel pressure on suction and discharge lines of the pumps was good before pump maintenance.
Fuel injector problems. Not possible, Injectors were replaced recently, and no parameter indicated a injector problem when engine was running.
Bad fuel conditions. Not possible once other engine was running at that time and using the same fuel.
Fuel feed pump wrong internal gear installed. Possible, once can compromise the fuel flow and/or pressure.
Fuel feed pump with clearance in internal gear. Possible, once can compromise fuel flow and/or pressure.
Solve the problem.
On that last step, once minimize the hypotheses, it is time to test each one, always starting from the easier one, to confirm and validate the hypotheses and finally find the solution for the problem. The correct diagnosis is extremely important. It is a critical part of the troubleshooting, once a wrong action can make you develop other undesirable problems and do the task harder, spending more time and producing emotional stress among the team and compromising the chance to quickly find the real problem. Remember to be organized and caution during the hands on for the tests.
Therefore, discovered the problem, the corrective action will be taken to put back on service the system/equipment. Remember to always log the problem with a report, thereby increasing the database to fix any such problems that may occur, and thus helping the team solve the problem in the future when you are not around.
Indeed, as the dart game has the intention to hit the bull’s-eye, the Dart of Vasconcelos has the intention to hit it and solve the problem, which is the main target.
A particular ship began to show a significant loss of lubricating oil in one of its main electric power generation engines, after maintenance of replacing the liners and sealing rings of the corresponding pistons. In that case, the troubleshooting would lead us, assisted of the Dart of Vasconcelos, to reason as follows: (Definition of the problem: Symptomatic) what could be causing this significant loss of lubricating oil (Create hypotheses: Logical Search)? How to determine the source of the problem (Reduce hypotheses: Contestation) and how to act to make the system/equipment operational again (Solve the problem: Solution)? [1].
Symptomatic:
Significant loss of lubricating oil. Title: “
Logical search:
Lube oil purifier discharging excessive lubricating oil to sludge tank.
Lube oil leaking from pumps or hoses.
Lubricating oil passing through combustion chamber due seal ring damaged.
Contestation:
Reducing Hypotheses:
Lube oil purifier discharging excessive lubricating oil to sludge tank. Not possible, once was monitored the sludge tank level and tank level was according with expected.
Lube oil leaking from pumps or hoses. Not possible. Was inspected all engine for external leaking and nothing unusual was found.
Lubricating oil passing through combustion chamber due seal ring damaged. Possible, once the seal rings were replaced during maintenance. It could be allowing part of the lubricating oil to pass into the combustion chamber and be burned together with the engine fuel.
Solution:
Solve the problem:
To validate the possible hypothesis, is necessary to test to confirm. One way to identify with lube oil has been burned together fuel is to observe the color of the exhaust gases from the engine. If it is bluish gray in color, this means that the lubricating oil is probably being burned together with the fuel.
Another easy test to do is a compression test performed on the cylinders that passed for the maintenance. The cylinder with low compression pressure should certainly be the cylinder with the problem.
Therefore, once done the correct diagnosis, proceed with the corrective action. Carry out the inspection on the cylinder with low compression pressure and confirm the damaged seal ring and then, replace it. Register the problem making a report, once it increases your database of troubleshooting for any similar problems that may happen and assist the team to solve problems when you are not around.
The Ishikawa diagram, or Fishbone diagram, as it is also known, is a cause-and-effect diagram that helps to find the root causes of a problem, analyzing the factors that involve the execution of the process. This method was created by the Japanese Kaoru Ishikawa in the 60’s and it’s highly used today in the most diverse industries. The main factor of the diagram is to consider all aspects that may have generated the problem, thus making it easier to organize ideas to arrive at a solution for the problem.
It is a fact that every problem has specific causes. Analyzing each cause and verifying the possibility that it is the root of the problem is the key to finding a solution. It is necessary, whenever possible, to analyze the simplest and most probable causes of the problem, in order to save time and avoid hard and exhausting work during troubleshooting.
The great relationship of the Ishikawa Diagram with the spine of a fish comes from the fact that we can consider the spines as the causes of the observed problems, which will contribute to the discovery of their effect. The Ishikawa Diagram has great applicability in different contexts and in different ways, among them, the use stands out:
To view the main and secondary causes of a problem (effect).
To broaden the vision of the possible causes of a problem, seeing it in a more systemic and comprehensive way.
To identify solutions, raising the resources available by the company.
To generate process improvements.
In order to carry out the Fishbone diagram, we must take the following steps:
Define the problem causes (effect) to be analyzed.
Draw a horizontal arrow pointing to the right and write the problem inside a rectangle located at the tip of the arrow.
Brainstorm to raise possible causes that may be causing the problem. To do this, try to answer the following question: “Why is this happening”.
Divide the causes identified into categories, for example: machine, manpower, method, mother-nature, measure and materials or in a way that is most consistent with the problem analyzed and the context of your company.
Right after, define the sub-causes, that is, the factors that caused that cause to happen.
The main categories represented in each of the spines are also known as the “6 M”, referring to the following items:
Manpower (People): involved in the process.
Method: The way the process is performed. What are the procedures used, rules and requirements.
Machine: The equipment involved in the process.
Measurement: Analyze the metrics used. Analyze all the data generated from the process looking for failures.
Material: Evaluate all material used in the process, parts, for example.
Mother-Nature (Environment): Analyze the conditions of the place where the process is developed.
It is easy to understand that the use of the diagram facilitates the visualization of the causes of problems and the effects caused by them. In addition, we cite as other benefits:
Facilitate team brainstorming, in order to facilitate the organization of ideas.
It helps to keep the focus of the whole team.
Show all possible causes at once, in an organized and segmented way.
It stimulates the solution of problems.
As an example of how to use the Ishikawa diagram, let us see how it would be applied to identify high coolant consumption in an Engine Room in engines plant. As explained before, first you need to do the sketch of the fishbone diagram, writing the “6Ms” (cause) to find out the problem (effect). Once done that, each one of the “6Ms” should be analyzed in separate, showing what could be caused the high coolant consumption in the engines plant. It assists the brainstorm and make easier to find out the real cause of the problem. Figure 2 shows exactly the diagram for the explained situation.
Example of Ishikawa diagram. Causes that increased the coolant consumption in a manufacturing plant [
Therefore, as seen, the diagram facilities the visualization of what could be causing the problem. The next step would be to analyze among all the election causes, what would be the correct one to the problem, for after that, check how to solve it.
Before all, it’s particularly important to say that both methods are good and can be used for any problem of cause and effect. Ishikawa diagram use a wider view of the situation, while Dart of Vasconcelos is more objective, making faster to figure out what is causing the problem. Ishikawa is a type of diagram that anyone can participate, independent of being a maintenance team member, for example, a painter can say his opinion about one problem with his vision, making sense or not. The Dart, on the other hand, suggests that only people with affinity in the task raise opinions, so it becomes more objective and practical. Other difference is that Ishikawa shows the causes that could be causing the problem; the dart of Vasconcelos shows the causes and a way to solve them. Somehow, the person performing the troubleshooting can analyze which one method should be better applied for the present problem. To a better understanding, let analyze one situation using both methods.
A specific diesel engine has been presented difficulty to start recently. Douglas, 2nd Marine Engineer, reported that this engine is with maintenance late and that has been presented an unusual and thick smoke from the exhaust gases. Therefore, could you find out the possible problem of the engine?
To proceed with that troubleshooting, let start using Ishikawa diagram and after the Dart of Vasconcelos. Therefore, building the fishbone for the problem, we have the following schematic illustrated in Figure 3.
Ishikawa’s diagram for engine with difficulty to start recently [
Observe that the diagram has several causes for the problem (effect) and each one should be analyzed to confirm if it is a possible cause or not. At same time that diagram facilities the visualization of the causes, depending on the problem it can have many causes and sub-causes, becoming hard and lingering the task, once it seeks to look at the problem as a whole, and not objectively, based on the affected system and the on temporal analysis. Therefore, let us analyzing each cause:
Polluted or rarefied ambient air. Not possible. Ambient inspected and nothing unusual observed.
Incorrect parts used for maintenance. Not possible. Double checked part number to confirm parts used are correct.
Poor quality of fuel. Not possible. Collected a sample and saw that was in good conditions.
Air filters dirty. Possible.
Fuel injection pump problem. Possible.
Fuel injector problem. Possible.
Problem in Turbocharger. Possible.
Incorrect parameters readings. Not possible. Confirmed that instrumentation was working properly.
Personnel not trained for the task. Not possible. Experienced crew on the task.
Incorrect maintenance procedure. Not possible, Procedure used direct from the manufacture manual.
Crew distracted during maintenances. Possible.
Ishikawa diagram gives 5 possibilities for the problem. Analyzing each one we have:
Therefore, electing the priority to be inspected (based on possibility and facility) we have inspect air filters, double check for the steps done with the crew during maintenance, inspect fuel injectors, inspect turbochargers, and inspect fuel injection pumps.
Now let us analyze the same proposed problem above using Dart of Vasconcelos:
Logical Search:
System affected: Fuel system and air system.
Temporal analysis: Engine is with maintenance late.
Creating Hypotheses:
Based on symptomatic and the logical search, is possible significantly reduce the quantity of hypotheses, for example, poor quality of fuel will not be considered as a cause, once only one “specific” engine presented the problem, if was a common problem, certainly fuel would be a great possibility. The same happen to polluted or rarefied ambient air, using temporal analysis, nothing make reference about changes on the work engine area to consider it as a cause. Note that using this method, is possible to be more specific and surgical on the troubleshooting, saving time with possibilities that really are important to find out the problem.
Indeed, the following hypotheses for the question are:
Reducing hypotheses.
Therefore, the possibilities of the problems were reduced in two, dirty air filters or injector problems. Starting from the easier to inspect and solve, inspect air filters for clogged and replace it. For fuel injector, inspect all injectors for carbonization on nozzle, test the pressure of opening and how the spray, and check for inappropriate injection timing is.
In summary, using both methods will be possible find the causes to finally solve the problem. Vasconcelos method shows more objectivity, and Ishikawa looks the problem as a whole. The person in charge doing the troubleshooting will decide which method will be better for each situation.
MTBF (mean time between failures) and MTTR (mean time to repair) are two indicators related to the availability of an Industrial Process.
These are the periods of time that are lost while the machine is running and can be averaged using a formula. We have to apply the total performance time during a predetermined cycle under the number of failure that occurred during such time. According the Formula: MTBF = (Total Available Time – Waiting Time) / (numbers of shutdowns in the period of operation).
Example a freshwater generator designed to operate for 24 hours per day. Suppose the freshwater generator shutdown three times in the span of 30 days. The first shutdown occurred 48 hours from the start time and took 6 hours to repair. The second shutdown occurred 240 hours from the start time and took 4 hours to repair and the last shutdown 480 hours from start time and took 2 hour to repair before the freshwater generator was operating normally.
MTBF = (30daysx24hours - (6 hours + 4 hours+2 hour))/(3 shutdowns in 30 days of operations time) = 714 hours/3 = 236 hours or a mean time of 9 days and 20 hours between failures in the span of 30 days of the freshwater generator operation time.
With this conclusion, strategies can be created to face a problem gradually associated with the equipment.
MTTR is calculated by applying the average time it takes to perform a repair after the failure episode. See the formula: MTTR = (Total repair time) / (number of failures). If you use the example above, you should get the following solution:
MTTR = (6 + 4 + 2) / 3 = 4 hours.
This solution establishes the average time that the equipment was stopped. Generating a relationship with the two indexes is the availability of this process.
AVAILABILITY = MTBF/(MTBF+ MTTR).
Therefore the availability of the freshwater generator in this process on board of a vessel is:
AVAILABILITY = 236 hours/(236 hours + 4 hours
Thus, the lower the MTTR and the higher the MTBF, the more efficient the maintenance team will work.
Reliability of an equipment is related with the MTTF (mean time to failure), or failure rate, which expresses the probability of the equipment failures during a given period of time. It’s normally applied to unrepairable devices, such as electronic devices and some relays with expected life of 300,000 cycles of operation or more or less 10 years of span life.
In this part, is showed the questions based in real cases. Some of questions, before to be presented, have an initial introduction about the subject debated into the question, in order to help the reader to solve the problem. The reader may use one of the cause and effect methods spoken in the beginning of this chapter and use the
A specific, Dynamic Position vessel class #02, with electric diesel engines, configured with two medium voltage busbars, a bus tie breaker, four brushless diesel generators, two fixed pitch propellers and four tunnel thrusters illustrated in Figure 4 [1].
Electric diesel vessel with 2 fixed thrusters and 4 tunnel thrusters [
Laura, an experienced Marine Engineer was ordered to prepare the engines, once the operations have finished at that port, so the vessel had to leave. The Diesel Generator 01 was on the busbar, with the bus tie breaker closed, as shown in Figure 5.
Screen from power management system (PMS) during vessel operation at the port [
Therefore, Laura activated the Power Management System (PMS), so that the others diesel generators feed the busbars, thus making four generators on the busbars, to then drive the propulsion’s loads. However, the engineer was surprised, as generator #02 did not assume the load, generating several alarms, among them Automatic Voltage Regulator (AVR) fault, in the protection relay of generator #02, illustrated in Figures 6 and 7.
Condition of screen from power management system (PMS) during the failure alarm [
Protection relay SEL – 7000G [
Observing on the Bridge, Figure 8, the Captain called to Engine Room to understand why the generator had not assumed the load, once the company’s procedure require that all generators should be on the busbars for the vessel to leave the port until navigation. Laura replied that she was investigating, doing her troubleshooting while, the Chief Engineer and the electrician were on their way to inspect the problem. Marine Engineer knew that this DP class #02 vessel had a lot of redundancy until arrives at the generator #02 busbars control cubicle, she recalled that each diesel generator had two AVRs, and then she quickly deselected the AVR #01 and selected the AVR #02, resetting the SEL 7000 bus protection relay.
AVR switch button [
At this moment, the Chief Engineer arrived at the Machinery Control Center (MCC) and Laura reported what she had done, promptly the Chief praised her and signaled her to continue the procedure that was underway with the electrician. Together, after all the conferences and resets, Laura, and the electrician Jair, issued the order for the PMS to start generator #02, which excited, synchronized, closed the circuit breaker on the busbars, and divided the load normally. Chief Engineer Nikola Tesla, asked to electrician Jair to look for a new AVR in the electric Warehouse, to replace the AVR #01, even so, Nikola thought about doing some tests.
Therefore, he requested that the Captain activate the tunnel thrusters above the port in two ways:
Slowly activating the thrusters with only generator #02 on the busbars.
Quickly triggering thrusters with generators #01 and # 02 on the portside busbars, illustrated in Figure 9.
Condition of main busbars during navigation to offshore operations [
Vessel responded well, there were no alarms, or the opening of the generator #02 circuit breaker on the busbars.
Thus, this vessel definitively left the port for navigation towards its offshore operations and the Chief returned to rest as well as the electrician, after troubleshooting, to then follow the next operations.
Gabriel, the First Engineer, assume his duty service, and after his normal round, started a revision service for a fuel oil purifier that Laura had started on her shift, once the ship was navigating, and there would be enough time to finish that maintenance service.
As soon as the maintenance started, Gabriel observed a change in the charge regime of generator #02 due to the sound emitted by it, and soon there was an alarm. The engineer went to the MCC, noting the condition of generator on PMS screen, seeing that the Generator had disconnected from the busbars with a series of alarms, among them: “AVR Fault”, again as illustrated in Figure 10.
Condition of main busbars during navigation after generator failure [
At this moment, the electrician Jair said: “we need to see this, can be a serious problem!”, because he knew that Laura had selected another AVR during troubleshooting, on the night before, and it would be very unlikely that both AVRs had failed.
Time was running out before the vessel reached the platform, so Gabriel decided to communicate Nikola, because only with three generators, there would be a reduction in contract speed, compromising the contract speed with the client. Since the vessel was equipped with PMS there was no blackout, the thrusters were automatically reduced and until then the Deck officers had not noticed any difference in the speed of navigation. So, when Chief Nikola arrives at MCC, Jair and Gabriel were already exchanging the AVR that Jair had already brought from the electric Warehouse. Nikola, very dissatisfied just observed what Gabriel and Jair were doing. Nikola is an experienced Chief Engineer and knew that the chance of two AVRs failing together would be very low. Therefore, Nikola looked for the excitation / load control diagram of generator #02, while Jair and Gabriel were replacing the AVR. Nikola knew the order of events in which a generator needs to synchronize in parallel with another generator:
Order to depart the generator that must happen in a certain time.
Exciting (or increasing the AVR tension value), that should happen in a certain time.
When achieving the tension value of the busbars, which cause small rotation slips until the generators and the busbars have the same phase angle that must to happen in a certain time.
When achieving the same phase angle displayed in the synchronoscope which must be an order to close the circuit breaker.
There are number of attempts to close the circuit breaker. If the circuit breaker does not close, there is an engine stop order.
When the breaker closes, the loading generator increases the AVR current injection as well as fuel injection in the diesel machine while the generators that are giving load do the reverse process.
Telemetry Mesh called “loading sharing” communicates data to ensure that the Kilo Watts (KW) load values in both generators are equal, maintaining the AVR control process / fuel injection according to the electric load charges of the busbars.
Before Chief Nikola continued his analysis, Jair and Gabriel notified the order of the change in the AVR. Not ensured about the change done, they started the test. Generator #02 curiously connected on the busbars normally. Jair and Gabriel, were incredibly happy, shook hands and praised each other. Nikola thanked, but still dissatisfied said: Let us test!
Thus, at this moment, Chief Mate Fernanda, who had already been notified, started to take charge in several ways, thrusters against each other, all forward and all reverse and still generator #02 remained on the busbars. Jair and Gabriel were certain that everything was right, after all, in these tests, generator #02 remained on the busbars, the tests were severe, if anything that had to happen would happen during the tests. When Jair went to boast to the Chief, Nikola, who was focused on reading the electrical diagram, said to him: I am going up, call me when this generator leaves the busbars again! Skeptical and upset Gabriel said: Chief, it is settled, we have done the tests! Nikola replied with a friendly smile: Dear friend, thank you for your effort, your work was excellent, but call me again when this generator is disconnected from the busbars. Nikola turned his back and left MCC.
Gabriel told to Jair that the Chief was very suspicious fellow. Jair said that Nikola thinks him is the master of all the machines, he thinks that he invented the generator! After all, the electrician was Jair. Gabriel already calmer, said: Jair, you know how it is, right? Chief is Chief.
Thus, Jair said goodbye to Gabriel and went to change some lamps of the vessel, and Gabriel went to continue the service in the Purifier of diesel oil.
Time passed, the purifier was set up, Gabriel called Danilo, Oiler, to clean the environment of the purifier, when again generator #02, presented unusual noise and failed!
Surprised and incredulous, Gabriel said: what a Chief! Going up to the MCC where the generator #02 cubicle was located, he found the Chief with a Laser Temperature Gun (LTG) in his hand, measuring temperature inside the generator #02 cubicle. Nikola called Jair and said, change this component, giving Jair an electric contactor, and pointing out on the board which one he wanted to be changed. Jair, feeling pressured by the constant defects, changed the component requested by Chief Nikola. Even when driving in different ways, thrusters against each other, all the power in front and all the power in reverse, generator #02 remained on the busbars. Nikola said: Now the problem is solved!
Therefore, could explain what was the Chief Nikola Tesla thinking and how he found out that the electric contactor was the real problem?
Solution:
To understand and solve this problem, is important observe the timeline analysis of the problem. Three AVRs failed. First AVR failure with Laura, it was replaced by it hot stand by AVR # 02 in 1 hour by Laura, and then failed again after 6 hours and was replaced by a new one in 1.5 hour of service, lastly, other AVR failed after 4 hours with Jair and Gabriel and again was replaced for a new one in 1.5 hour of service. The same failure happens with all AVRs, what easily suggest that the problem may not be this component and yes, another item common to for the AVRs. The purpose of an AVR, illustrated in Figure 11 is to control the voltage of a generator by injecting current into the exciting coil. When you turn on a heater in your cabin, for example, the current in the generator armature increases and the magnetic field crossing the armature decreases due Lenz law, so the output voltage drops. To prevent this to occur, the AVR increases the current injection in the main exciter, increasing the magnetic field of the coil, consequently the field crossing the armature, and finally the output voltage to it set point.
Excitation system for a brushless alternator [
When someone turns on a lamp, the AVR injects more current into the main exciter, when someone turns off, the AVR decreases the excitation, so the set point remains constant. If this control were manual, you would be in front of the electrical energy board all day increasing or decreasing the field excitation value manually. But what is it to do with this contactor?
The contactor switches the AVR, without power the AVR does not works, if this contactor fails, the AVR fails. On the Other hands, if so, the generator would not work under any conditions, even when the AVRs were changed, much less in the tests performed, and every time the generator was switched on, it would fail, as it would not reach the excitation voltage. However, this was an intermittent failure. Observe the Direct Chain (DC) voltage coil illustrated in Figure 12.
DC voltage CWM coil [
This coil works with a small voltage value, so it must be relatively large to keep the contactor’s contacts closed, it must have many turns to have a great magnetomotive force at a little current, so the wire gauge is small. The vessel was more than 10 years and probably that coil was never changed, suffering years of heating on it made the varnish of the wire that constitutes the coil lose its insulation, even more when in use, this short-circuits insulation, causing the coil to lose some turns, decreasing the magnetomotive force. During some heating, the coil loses strength, the ship vibrates, this generates an instant lapse by opening the contacts and closing again, which switches off the AVR, so the generator stays momentarily without voltage control, so there will be no way to work in parallel with another engine. Therefore, it was what happened. Figure 13 shows the damaged contactor disassembled.
Disassembled CWM DC contactor [
Note that the contacts are in bad conditions. When Chief Engineer was checking the temperature inside of electrical board, he observed the contactor (common for both AVRs) heater than the others. Usually, the number of operations wears the contacts and thus, the contactor has some defect, bad terminals, or something, but it was measured an increase in the temperature of the coil and not in the contacts. in a DC coil, the current is limited by the ohmic resistance of the wire, so it needs a lot of turns, to produce a strong magnetomotive force to close tightly the contacts So, it was a real guess, because it’s known that coils are sensitive to temperature, after all the temperature degrades the varnish isolation.
When was disassembled another contactor of a new model, it was possible to compare and ratify the Chief Engineer theory, as illustrated in Figure 14.
Disassembled new contactor model [
Notice that the coil of the new models is smaller and has an electronic card, the 24 VDC supply feeds the card which energizes the coil, the card generates an alternating current (AC) wave, which feeds the coil. So, who starts to limit the current value is the impedance of the coil, the number of turns of the coil decreases due to the inductance, so the length of the coil decreases, the ohmic resistance of the wire decreases, thus, the heating decreases, less resistance, less active power dissipated in the form of heat, less heat, greater longevity for the coil lifespan.
Indeed, a simple electric contactor was causing those all problems and compromising the safety navigation of the ship. A better analysis and a correct diagnosis are especially important; otherwise you can create even bigger problems.
Mariners Engineers work in shifts of 08 hours as can be seen in Figure 15, showing the timeline of this failure of generator # 02.
Timeline for the failures in the generator # 02 synchronization in the busbars.
MTBF for the failures in generator # 02 in the period of 2 shifts of 08 hours:
MTBF = (2 shiftsx08hours - (1 hours+1.5 hours +1.5 hours))/(3 shutdowns in 16 hours) = (16–4) hours/3 shutdowns = 12/3 = 4 hours.
MTTR is calculated by applying the average time it takes to perform a repair after the failure episode.
MTTR = (Total repair time) / (number of failures). According Figure 15 we have:
MTTR = (1 + 1.5 + 1.5) / 3 = 4/3 = 1.33 hours.
AVAILABILITY = MTBF/(MTBF+ MTTR).
Therefore the availability of the generator # 02 in 2 shifts is:
AVAILABILITY = 4 hours/(4 hours+1.33 hours) = (4/5.33)x100 = 75%.
The reliability (MTTF) for the DC relay, is considered as for unrepairable devices, in this case it is hope the lifespan of 10 years for this relay, so its failure is consider due to lifespan.
The new relay with AC coil it is expect a longer lifespan than for the DC coil relay due to lesser Joule loss in the AC coil, and Chief Tesla will implement a predictive maintenance plan, measuring the temperature in the electric cubicle in every six month.
The objective of this chapter is to contribute with readers responsible for the maintenance of vessels, petro rigs and any industrial processes control plant.
Focused on a smart way for rapidly to solve routine problems on board faced by Marine Engineers, it was prepared a revision in the literature concerning troubleshooting, describing how to prepare and use the Ishikawa diagram and also compare with the dart of Vasconcelos developed by Saulo Vasconcelos. In this real case study the Chief Engineer applied the dart of Vasconcelos to reduce the MTTR and shows the solution for the electric problem of the electric generation # 02, caused by an electric contactor that switches the AVR (Automatic Voltage Regulator), The Mariners Engineers, without troubleshooting the problem replaced three times the AVRs without success to find the root cause of the problem. The Chief Nicola Tesla, applying the dart of Vasconcelos, reached the bull’s eye of the problem, the old DC electric contactor. The dart of Vasconcelos directs for root cause and also to avoid future problem, recording the timeline of the problems until the final action, in this real case study the installation of new electric contactor with AC coil with longer lifespan for its AC coil, increasing availability and reliability of the Diesel-electric system of this ship.
The authors would like to thanks the LORD GOD for this opportunity, the Admiral Braz de Aguiar Maritime Academy for the authorization to public this work, and to inTechOpen Access Publisher for the virtuous circle created to share knowledge between readers and authors.
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Cárdenas-Aguayo, M. del C. Silva-Lucero, M. Cortes-Ortiz,\nB. Jiménez-Ramos, L. Gómez-Virgilio, G. Ramírez-Rodríguez, E. Vera-\nArroyo, R. Fiorentino-Pérez, U. García, J. 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Miller and Grant M. Hatch",authors:[{id:"130802",title:"Dr.",name:"Grant",middleName:null,surname:"Hatch",slug:"grant-hatch",fullName:"Grant Hatch"},{id:"170126",title:"Prof.",name:"Donald",middleName:null,surname:"Miller",slug:"donald-miller",fullName:"Donald Miller"},{id:"170127",title:"Mr.",name:"Michael",middleName:null,surname:"Pogorzelec",slug:"michael-pogorzelec",fullName:"Michael Pogorzelec"},{id:"170128",title:"Ms.",name:"Hieu",middleName:null,surname:"Nguyen",slug:"hieu-nguyen",fullName:"Hieu Nguyen"},{id:"170129",title:"Dr.",name:"Ngoc",middleName:null,surname:"On",slug:"ngoc-on",fullName:"Ngoc On"},{id:"170130",title:"Dr.",name:"Siddhartha",middleName:null,surname:"Dalvi",slug:"siddhartha-dalvi",fullName:"Siddhartha Dalvi"}]},{id:"59071",doi:"10.5772/intechopen.74023",title:"Introductory Chapter: GABA/Glutamate Balance: A Key for Normal Brain Functioning",slug:"introductory-chapter-gaba-glutamate-balance-a-key-for-normal-brain-functioning",totalDownloads:1631,totalCrossrefCites:5,totalDimensionsCites:12,abstract:null,book:{id:"6237",slug:"gaba-and-glutamate-new-developments-in-neurotransmission-research",title:"GABA And Glutamate",fullTitle:"GABA And Glutamate - New Developments In Neurotransmission Research"},signatures:"Janko Samardzic, Dragana Jadzic, Boris Hencic, Jasna Jancic and\nDubravka Svob Strac",authors:[{id:"188756",title:"Dr.",name:"Janko",middleName:null,surname:"Samardzic",slug:"janko-samardzic",fullName:"Janko Samardzic"},{id:"398264",title:"Dr.",name:"Dragana",middleName:null,surname:"Jadzic",slug:"dragana-jadzic",fullName:"Dragana Jadzic"},{id:"398265",title:"Dr.",name:"Boris",middleName:null,surname:"Hencic",slug:"boris-hencic",fullName:"Boris Hencic"},{id:"398266",title:"Dr.",name:"Jasna",middleName:null,surname:"Jancic",slug:"jasna-jancic",fullName:"Jasna Jancic"},{id:"398267",title:"Dr.",name:"Dubravka Svob",middleName:null,surname:"Strac",slug:"dubravka-svob-strac",fullName:"Dubravka Svob Strac"}]},{id:"64031",doi:"10.5772/intechopen.81224",title:"Trends of Protein Aggregation in Neurodegenerative Diseases",slug:"trends-of-protein-aggregation-in-neurodegenerative-diseases",totalDownloads:1603,totalCrossrefCites:6,totalDimensionsCites:11,abstract:"Protein aggregation trends in neurodegenerative diseases are largely unmapped due to the complex nature of protein-protein interactions and their regulatory machineries such as protein proteolytic systems. Since the protein aggregation process in humans is a slow process, early determination of the patients that will develop neurodegenerative diseases later in life is critical in terms of starting effective treatment, which will reduce the expensive health care. In this chapter, I will discuss the nature of protein aggregation of signature proteins and the status of protein proteolytic systems such as proteasome and autophagosome in Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, frontotemporal lobar degeneration, Huntington’s disease, and prion disease under the light of recent studies including our new findings.",book:{id:"7480",slug:"neurochemical-basis-of-brain-function-and-dysfunction",title:"Neurochemical Basis of Brain Function and Dysfunction",fullTitle:"Neurochemical Basis of Brain Function and Dysfunction"},signatures:"Abdulbaki Agbas",authors:[{id:"250609",title:"Prof.",name:"Abdulbaki",middleName:null,surname:"Agbas",slug:"abdulbaki-agbas",fullName:"Abdulbaki Agbas"}]},{id:"62431",doi:"10.5772/intechopen.79266",title:"The United Chemicals of Cannabis: Beneficial Effects of Cannabis Phytochemicals on the Brain and Cognition",slug:"the-united-chemicals-of-cannabis-beneficial-effects-of-cannabis-phytochemicals-on-the-brain-and-cogn",totalDownloads:1817,totalCrossrefCites:3,totalDimensionsCites:11,abstract:"‘Medicinal cannabis’ can be defined as pharmaceutical grade cannabis-based products used for the treatment of illness. Beneficial treatment effects of cannabidiol (CBD), a major non-intoxicating compound isolated from the cannabis plant, have been shown in multiple states of cognitive impairment, including neurodegenerative (Alzheimer’s, Huntington’s and Parkinson’s disease), neuroinflammatory (sepsis-induced encephalopathy) and neurological disorders (ischemic brain injury). CBD can also treat some of the symptoms of schizophrenia, including cognitive deficits (impairments in learning and memory), which is a major symptom domain of the illness that is largely resistant to existing antipsychotic medications. However, empirical evidence suggests the presence of an ‘entourage effect’ in cannabis; that is, observations that medicinal cannabis seems to work better in some instances when administered as a whole-plant extract. While scientific evidence highlights isolated CBD as a strong candidate for treating cognitive impairment, the entourage effect suggests that the co-operation of other plant molecules could provide further benefits. This chapter explores the scientific evidence surrounding the benefits of CBD and other specific key phytochemicals in cannabis: linalool, α-pinene, β-caryophyllene, flavonoids and anthocyanin, on brain health and cognition.",book:{id:"7040",slug:"recent-advances-in-cannabinoid-research",title:"Recent Advances in Cannabinoid Research",fullTitle:"Recent Advances in Cannabinoid Research"},signatures:"Katrina Weston-Green",authors:null}],mostDownloadedChaptersLast30Days:[{id:"57103",title:"GABA and Glutamate: Their Transmitter Role in the CNS and Pancreatic Islets",slug:"gaba-and-glutamate-their-transmitter-role-in-the-cns-and-pancreatic-islets",totalDownloads:3524,totalCrossrefCites:3,totalDimensionsCites:9,abstract:"Glutamate and gamma-aminobutyric acid (GABA) are the major neurotransmitters in the mammalian brain. Inhibitory GABA and excitatory glutamate work together to control many processes, including the brain’s overall level of excitation. The contributions of GABA and glutamate in extra-neuronal signaling are by far less widely recognized. In this chapter, we first discuss the role of both neurotransmitters during development, emphasizing the importance of the shift from excitatory to inhibitory GABAergic neurotransmission. The second part summarizes the biosynthesis and role of GABA and glutamate in neurotransmission in the mature brain, and major neurological disorders associated with glutamate and GABA receptors and GABA release mechanisms. The final part focuses on extra-neuronal glutamatergic and GABAergic signaling in pancreatic islets of Langerhans, and possible associations with type 1 diabetes mellitus.",book:{id:"6237",slug:"gaba-and-glutamate-new-developments-in-neurotransmission-research",title:"GABA And Glutamate",fullTitle:"GABA And Glutamate - New Developments In Neurotransmission Research"},signatures:"Christiane S. Hampe, Hiroshi Mitoma and Mario Manto",authors:[{id:"210220",title:"Prof.",name:"Christiane",middleName:null,surname:"Hampe",slug:"christiane-hampe",fullName:"Christiane Hampe"},{id:"210485",title:"Prof.",name:"Mario",middleName:null,surname:"Manto",slug:"mario-manto",fullName:"Mario Manto"},{id:"210486",title:"Prof.",name:"Hiroshi",middleName:null,surname:"Mitoma",slug:"hiroshi-mitoma",fullName:"Hiroshi Mitoma"}]},{id:"58817",title:"Clinical Application of MR Spectroscopy in Identifying Biochemical Composition of the Intracranial Pathologies",slug:"clinical-application-of-mr-spectroscopy-in-identifying-biochemical-composition-of-the-intracranial-p",totalDownloads:2064,totalCrossrefCites:0,totalDimensionsCites:5,abstract:"Magnetic resonance spectroscopy (MRS) provides useful information regarding metabolic composition in the tissues, and advanced spectroscopic methods are used to quantify markers of tumor membrane turnover and proliferation (e.g., choline (Cho)), energy homoeostasis (e.g., creatine (Cr)), intact glioneuronal structures (e.g., N-acetylaspartate (NAA)), and necrosis (e.g., lactate (Lac) or lipids). Results are usually expressed as metabolite ratios rather than absolute metabolite concentrations. Because glial tumors have some specific metabolic characteristics that differ according to the grade of tumor, there is a potential for MR spectroscopy to increase the sensitivity of routinely used diagnostic imaging. MRS also has many diagnostic applications in neurosciences to support the diagnosis in conditions like demyelination, infections, and dementia and in postradiotherapy cases. Biochemical changes in the metabolism of tumor cells related to malignant transformation are reflected in changes of particular metabolite concentration in the tumor tissue. Our prospective study aimed to analyze the usefulness of proton MR spectroscopy in grading of glioma and to correlate various metabolite ratios like choline/creatine, choline/N-acetylaspartate, N-acetylaspartate/creatine, and lactate/creatine with the histopathological grades of glioma.",book:{id:"6237",slug:"gaba-and-glutamate-new-developments-in-neurotransmission-research",title:"GABA And Glutamate",fullTitle:"GABA And Glutamate - New Developments In Neurotransmission Research"},signatures:"B C Hamsini, Bhavana Nagabhushana Reddy, Sankar Neelakantan\nand Sunitha Palasamudram Kumaran",authors:[{id:"211054",title:"Dr.",name:"Sunitha",middleName:null,surname:"P Kumaran",slug:"sunitha-p-kumaran",fullName:"Sunitha P Kumaran"},{id:"221485",title:"Dr.",name:"Sankar",middleName:null,surname:"Neelakantan",slug:"sankar-neelakantan",fullName:"Sankar Neelakantan"},{id:"398223",title:"Dr.",name:"B C",middleName:null,surname:"Hamsini",slug:"b-c-hamsini",fullName:"B C Hamsini"},{id:"398224",title:"Dr.",name:"Bhavana",middleName:null,surname:"Nagabhushana Reddy",slug:"bhavana-nagabhushana-reddy",fullName:"Bhavana Nagabhushana Reddy"}]},{id:"62431",title:"The United Chemicals of Cannabis: Beneficial Effects of Cannabis Phytochemicals on the Brain and Cognition",slug:"the-united-chemicals-of-cannabis-beneficial-effects-of-cannabis-phytochemicals-on-the-brain-and-cogn",totalDownloads:1813,totalCrossrefCites:3,totalDimensionsCites:11,abstract:"‘Medicinal cannabis’ can be defined as pharmaceutical grade cannabis-based products used for the treatment of illness. Beneficial treatment effects of cannabidiol (CBD), a major non-intoxicating compound isolated from the cannabis plant, have been shown in multiple states of cognitive impairment, including neurodegenerative (Alzheimer’s, Huntington’s and Parkinson’s disease), neuroinflammatory (sepsis-induced encephalopathy) and neurological disorders (ischemic brain injury). CBD can also treat some of the symptoms of schizophrenia, including cognitive deficits (impairments in learning and memory), which is a major symptom domain of the illness that is largely resistant to existing antipsychotic medications. However, empirical evidence suggests the presence of an ‘entourage effect’ in cannabis; that is, observations that medicinal cannabis seems to work better in some instances when administered as a whole-plant extract. While scientific evidence highlights isolated CBD as a strong candidate for treating cognitive impairment, the entourage effect suggests that the co-operation of other plant molecules could provide further benefits. This chapter explores the scientific evidence surrounding the benefits of CBD and other specific key phytochemicals in cannabis: linalool, α-pinene, β-caryophyllene, flavonoids and anthocyanin, on brain health and cognition.",book:{id:"7040",slug:"recent-advances-in-cannabinoid-research",title:"Recent Advances in Cannabinoid Research",fullTitle:"Recent Advances in Cannabinoid Research"},signatures:"Katrina Weston-Green",authors:null},{id:"68776",title:"Introductory Chapter: The Chemical Basis of Neural Function and Dysfunction",slug:"introductory-chapter-the-chemical-basis-of-neural-function-and-dysfunction",totalDownloads:1110,totalCrossrefCites:1,totalDimensionsCites:2,abstract:null,book:{id:"7480",slug:"neurochemical-basis-of-brain-function-and-dysfunction",title:"Neurochemical Basis of Brain Function and Dysfunction",fullTitle:"Neurochemical Basis of Brain Function and Dysfunction"},signatures:"Thomas Heinbockel and Antonei B. Csoka",authors:[{id:"70569",title:"Dr.",name:"Thomas",middleName:null,surname:"Heinbockel",slug:"thomas-heinbockel",fullName:"Thomas Heinbockel"},{id:"245650",title:"Dr.",name:"Antonei B.",middleName:null,surname:"Csoka",slug:"antonei-b.-csoka",fullName:"Antonei B. Csoka"}]},{id:"68712",title:"Synaptic Transmission and Amino Acid Neurotransmitters",slug:"synaptic-transmission-and-amino-acid-neurotransmitters",totalDownloads:1361,totalCrossrefCites:6,totalDimensionsCites:7,abstract:"Amino acids are the most abundant neurotransmitters in the brain. Neurotransmitters are synthesized and stored in presynaptic terminals, released from terminals upon stimulation with specific receptors on the postsynaptic cells. Chemical and electrical synapses are specialized biological structures found in the nervous system; they connect neurons together and transmit signals across the neurons. The process of synaptic transmission generates or inhibits electrical impulses in a network of neurons for the processing of information. Glutamate is the primary excitatory neurotransmitter in the brain, while GABA is the principal inhibitory neurotransmitter. The balance of glutamatergic and GABAergic tone is crucial to normal neurologic function. Through synaptic transmission, this information is communicated from the presynaptic cell to the postsynaptic cell. Amino acid neurotransmitters primarily glutamic acid, GABA, aspartic acid, and glycine are single amino acid residues released from presynaptic nerve terminals in response to an action potential and cross the synaptic cleft to bind with specific receptor on the postsynaptic membrane. The integral role of amino acid neurotransmitters is important on the normal functioning of the brain. The presynaptic and postsynaptic events in chemical synapses are subject to use dependent and highly regulated as per the changes in synaptic neurotransmitter release and function.",book:{id:"7480",slug:"neurochemical-basis-of-brain-function-and-dysfunction",title:"Neurochemical Basis of Brain Function and Dysfunction",fullTitle:"Neurochemical Basis of Brain Function and Dysfunction"},signatures:"Manorama Patri",authors:[{id:"196763",title:"Dr.",name:"Manorama",middleName:null,surname:"Patri",slug:"manorama-patri",fullName:"Manorama Patri"}]}],onlineFirstChaptersFilter:{topicId:"212",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:0,limit:8,total:null},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:32,numberOfPublishedChapters:320,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:133,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:5,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:17,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. 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Dr. Madfa also regularly attends international conferences and holds administrative positions (Deputy Dean of the Faculty for Students’ & Academic Affairs and Deputy Head of Research Unit).",institutionString:"Thamar University",institution:null},{id:"210472",title:"Dr.",name:"Nermin",middleName:"Mohammed Ahmed",surname:"Yussif",slug:"nermin-yussif",fullName:"Nermin Yussif",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/210472/images/system/210472.jpg",biography:"Dr. Nermin Mohammed Ahmed Yussif is working at the Faculty of dentistry, University for October university for modern sciences and arts (MSA). Her areas of expertise include: periodontology, dental laserology, oral implantology, periodontal plastic surgeries, oral mesotherapy, nutrition, dental pharmacology. She is an editor and reviewer in numerous international journals.",institutionString:"MSA University",institution:null},{id:"204606",title:"Dr.",name:"Serdar",middleName:null,surname:"Gözler",slug:"serdar-gozler",fullName:"Serdar Gözler",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204606/images/system/204606.jpeg",biography:"Dr. Serdar Gözler has completed his undergraduate studies at the Marmara University Faculty of Dentistry in 1978, followed by an assistantship in the Prosthesis Department of Dicle University Faculty of Dentistry. Starting his PhD work on non-resilient overdentures with Assoc. Prof. Hüsnü Yavuzyılmaz, he continued his studies with Prof. Dr. Gürbüz Öztürk of Istanbul University Faculty of Dentistry Department of Prosthodontics, this time on Gnatology. He attended training programs on occlusion, neurology, neurophysiology, EMG, radiology and biostatistics. In 1982, he presented his PhD thesis \\Gerber and Lauritzen Occlusion Analysis Techniques: Diagnosis Values,\\ at Istanbul University School of Dentistry, Department of Prosthodontics. As he was also working with Prof. Senih Çalıkkocaoğlu on The Physiology of Chewing at the same time, Gözler has written a chapter in Çalıkkocaoğlu\\'s book \\Complete Prostheses\\ entitled \\The Place of Neuromuscular Mechanism in Prosthetic Dentistry.\\ The book was published five times since by the Istanbul University Publications. Having presented in various conferences about occlusion analysis until 1998, Dr. Gözler has also decided to use the T-Scan II occlusion analysis method. Having been personally trained by Dr. Robert Kerstein on this method, Dr. Gözler has been lecturing on the T-Scan Occlusion Analysis Method in conferences both in Turkey and abroad. Dr. Gözler has various articles and presentations on Digital Occlusion Analysis methods. He is now Head of the TMD Clinic at Prosthodontic Department of Faculty of Dentistry , Istanbul Aydın University , Turkey.",institutionString:"Istanbul Aydin University",institution:{name:"Istanbul Aydın University",country:{name:"Turkey"}}},{id:"240870",title:"Ph.D.",name:"Alaa Eddin Omar",middleName:null,surname:"Al Ostwani",slug:"alaa-eddin-omar-al-ostwani",fullName:"Alaa Eddin Omar Al Ostwani",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/240870/images/system/240870.jpeg",biography:"Dr. Al Ostwani Alaa Eddin Omar received his Master in dentistry from Damascus University in 2010, and his Ph.D. in Pediatric Dentistry from Damascus University in 2014. Dr. Al Ostwani is an assistant professor and faculty member at IUST University since 2014. \nDuring his academic experience, he has received several awards including the scientific research award from the Union of Arab Universities, the Syrian gold medal and the international gold medal for invention and creativity. Dr. Al Ostwani is a Member of the International Association of Dental Traumatology and the Syrian Society for Research and Preventive Dentistry since 2017. He is also a Member of the Reviewer Board of International Journal of Dental Medicine (IJDM), and the Indian Journal of Conservative and Endodontics since 2016.",institutionString:"International University for Science and Technology.",institution:{name:"Islamic University of Science and Technology",country:{name:"India"}}},{id:"42847",title:"Dr.",name:"Belma",middleName:null,surname:"Işik Aslan",slug:"belma-isik-aslan",fullName:"Belma Işik Aslan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/42847/images/system/42847.jpg",biography:"Dr. Belma IşIk Aslan was born in 1976 in Ankara-TURKEY. After graduating from TED Ankara College in 1994, she attended to Gazi University, Faculty of Dentistry in Ankara. She completed her PhD in orthodontic education at Gazi University between 1999-2005. Dr. Işık Aslan stayed at the Providence Hospital Craniofacial Institude and Reconstructive Surgery in Michigan, USA for three months as an observer. She worked as a specialist doctor at Gazi University, Dentistry Faculty, Department of Orthodontics between 2005-2014. She was appointed as associate professor in January, 2014 and as professor in 2021. Dr. Işık Aslan still works as an instructor at the same faculty. She has published a total of 35 articles, 10 book chapters, 39 conference proceedings both internationally and nationally. Also she was the academic editor of the international book 'Current Advances in Orthodontics'. She is a member of the Turkish Orthodontic Society and Turkish Cleft Lip and Palate Society. She is married and has 2 children. Her knowledge of English is at an advanced level.",institutionString:"Gazi University Dentistry Faculty Department of Orthodontics",institution:null},{id:"178412",title:"Associate Prof.",name:"Guhan",middleName:null,surname:"Dergin",slug:"guhan-dergin",fullName:"Guhan Dergin",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178412/images/6954_n.jpg",biography:"Assoc. Prof. Dr. Gühan Dergin was born in 1973 in Izmit. He graduated from Marmara University Faculty of Dentistry in 1999. He completed his specialty of OMFS surgery in Marmara University Faculty of Dentistry and obtained his PhD degree in 2006. In 2005, he was invited as a visiting doctor in the Oral and Maxillofacial Surgery Department of the University of North Carolina, USA, where he went on a scholarship. Dr. Dergin still continues his academic career as an associate professor in Marmara University Faculty of Dentistry. He has many articles in international and national scientific journals and chapters in books.",institutionString:null,institution:{name:"Marmara University",country:{name:"Turkey"}}},{id:"178414",title:"Prof.",name:"Yusuf",middleName:null,surname:"Emes",slug:"yusuf-emes",fullName:"Yusuf Emes",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178414/images/6953_n.jpg",biography:"Born in Istanbul in 1974, Dr. Emes graduated from Istanbul University Faculty of Dentistry in 1997 and completed his PhD degree in Istanbul University faculty of Dentistry Department of Oral and Maxillofacial Surgery in 2005. He has papers published in international and national scientific journals, including research articles on implantology, oroantral fistulas, odontogenic cysts, and temporomandibular disorders. Dr. Emes is currently working as a full-time academic staff in Istanbul University faculty of Dentistry Department of Oral and Maxillofacial Surgery.",institutionString:null,institution:{name:"Istanbul University",country:{name:"Turkey"}}},{id:"192229",title:"Ph.D.",name:"Ana Luiza",middleName:null,surname:"De Carvalho Felippini",slug:"ana-luiza-de-carvalho-felippini",fullName:"Ana Luiza De Carvalho Felippini",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192229/images/system/192229.jpg",biography:null,institutionString:"University of São Paulo",institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"256851",title:"Prof.",name:"Ayşe",middleName:null,surname:"Gülşen",slug:"ayse-gulsen",fullName:"Ayşe Gülşen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/256851/images/9696_n.jpg",biography:"Dr. Ayşe Gülşen graduated in 1990 from Faculty of Dentistry, University of Ankara and did a postgraduate program at University of Gazi. \nShe worked as an observer and research assistant in Craniofacial Surgery Departments in New York, Providence Hospital in Michigan and Chang Gung Memorial Hospital in Taiwan. \nShe works as Craniofacial Orthodontist in Department of Aesthetic, Plastic and Reconstructive Surgery, Faculty of Medicine, University of Gazi, Ankara Turkey since 2004.",institutionString:"Univeristy of Gazi",institution:null},{id:"255366",title:"Prof.",name:"Tosun",middleName:null,surname:"Tosun",slug:"tosun-tosun",fullName:"Tosun Tosun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255366/images/7347_n.jpg",biography:"Graduated at the Faculty of Dentistry, University of Istanbul, Turkey in 1989;\nVisitor Assistant at the University of Padua, Italy and Branemark Osseointegration Center of Treviso, Italy between 1993-94;\nPhD thesis on oral implantology in University of Istanbul and was awarded the academic title “Dr.med.dent.”, 1997;\nHe was awarded the academic title “Doç.Dr.” (Associated Professor) in 2003;\nProficiency in Botulinum Toxin Applications, Reading-UK in 2009;\nMastership, RWTH Certificate in Laser Therapy in Dentistry, AALZ-Aachen University, Germany 2009-11;\nMaster of Science (MSc) in Laser Dentistry, University of Genoa, Italy 2013-14.\n\nDr.Tosun worked as Research Assistant in the Department of Oral Implantology, Faculty of Dentistry, University of Istanbul between 1990-2002. \nHe worked part-time as Consultant surgeon in Harvard Medical International Hospitals and John Hopkins Medicine, Istanbul between years 2007-09.\u2028He was contract Professor in the Department of Surgical and Diagnostic Sciences (DI.S.C.), Medical School, University of Genova, Italy between years 2011-16. \nSince 2015 he is visiting Professor at Medical School, University of Plovdiv, Bulgaria. \nCurrently he is Associated Prof.Dr. at the Dental School, Oral Surgery Dept., Istanbul Aydin University and since 2003 he works in his own private clinic in Istanbul, Turkey.\u2028\nDr.Tosun is reviewer in journal ‘Laser in Medical Sciences’, reviewer in journal ‘Folia Medica\\', a Fellow of the International Team for Implantology, Clinical Lecturer of DGZI German Association of Oral Implantology, Expert Lecturer of Laser&Health Academy, Country Representative of World Federation for Laser Dentistry, member of European Federation of Periodontology, member of Academy of Laser Dentistry. Dr.Tosun presents papers in international and national congresses and has scientific publications in international and national journals. He speaks english, spanish, italian and french.",institutionString:null,institution:{name:"Istanbul Aydın University",country:{name:"Turkey"}}},{id:"260116",title:"Dr.",name:"Mehmet",middleName:null,surname:"Yaltirik",slug:"mehmet-yaltirik",fullName:"Mehmet Yaltirik",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/260116/images/7413_n.jpg",biography:"Birth Date 25.09.1965\r\nBirth Place Adana- Turkey\r\nSex Male\r\nMarrial Status Bachelor\r\nDriving License Acquired\r\nMother Tongue Turkish\r\n\r\nAddress:\r\nWork:University of Istanbul,Faculty of Dentistry, Department of Oral Surgery and Oral Medicine 34093 Capa,Istanbul- TURKIYE",institutionString:null,institution:{name:"Istanbul University",country:{name:"Turkey"}}},{id:"171887",title:"Prof.",name:"Zühre",middleName:null,surname:"Akarslan",slug:"zuhre-akarslan",fullName:"Zühre Akarslan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/171887/images/system/171887.jpg",biography:"Zühre Akarslan was born in 1977 in Cyprus. She graduated from Gazi University Faculty of Dentistry, Ankara, Turkey in 2000. \r\nLater she received her Ph.D. degree from the Oral Diagnosis and Radiology Department; which was recently renamed as Oral and Dentomaxillofacial Radiology, from the same university. \r\nShe is working as a full-time Associate Professor and is a lecturer and an academic researcher. \r\nHer expertise areas are dental caries, cancer, dental fear and anxiety, gag reflex in dentistry, oral medicine, and dentomaxillofacial radiology.",institutionString:"Gazi University",institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"256417",title:"Associate Prof.",name:"Sanaz",middleName:null,surname:"Sadry",slug:"sanaz-sadry",fullName:"Sanaz Sadry",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/256417/images/8106_n.jpg",biography:null,institutionString:null,institution:null},{id:"272237",title:"Dr.",name:"Pinar",middleName:"Kiymet",surname:"Karataban",slug:"pinar-karataban",fullName:"Pinar Karataban",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/272237/images/8911_n.png",biography:"Assist.Prof.Dr.Pınar Kıymet Karataban, DDS PhD \n\nDr.Pınar Kıymet Karataban was born in Istanbul in 1975. After her graduation from Marmara University Faculty of Dentistry in 1998 she started her PhD in Paediatric Dentistry focused on children with special needs; mainly children with Cerebral Palsy. She finished her pHD thesis entitled \\'Investigation of occlusion via cast analysis and evaluation of dental caries prevalance, periodontal status and muscle dysfunctions in children with cerebral palsy” in 2008. She got her Assist. Proffessor degree in Istanbul Aydın University Paediatric Dentistry Department in 2015-2018. ın 2019 she started her new career in Bahcesehir University, Istanbul as Head of Department of Pediatric Dentistry. In 2020 she was accepted to BAU International University, Batumi as Professor of Pediatric Dentistry. She’s a lecturer in the same university meanwhile working part-time in private practice in Ege Dental Studio (https://www.egedisklinigi.com/) a multidisciplinary dental clinic in Istanbul. Her main interests are paleodontology, ancient and contemporary dentistry, oral microbiology, cerebral palsy and special care dentistry. She has national and international publications, scientific reports and is a member of IAPO (International Association for Paleodontology), IADH (International Association of Disability and Oral Health) and EAPD (European Association of Pediatric Dentistry).",institutionString:null,institution:null},{id:"202198",title:"Dr.",name:"Buket",middleName:null,surname:"Aybar",slug:"buket-aybar",fullName:"Buket Aybar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202198/images/6955_n.jpg",biography:"Buket Aybar, DDS, PhD, was born in 1971. She graduated from Istanbul University, Faculty of Dentistry, in 1992 and completed her PhD degree on Oral and Maxillofacial Surgery in Istanbul University in 1997.\nDr. Aybar is currently a full-time professor in Istanbul University, Faculty of Dentistry Department of Oral and Maxillofacial Surgery. She has teaching responsibilities in graduate and postgraduate programs. Her clinical practice includes mainly dentoalveolar surgery.\nHer topics of interest are biomaterials science and cell culture studies. She has many articles in international and national scientific journals and chapters in books; she also has participated in several scientific projects supported by Istanbul University Research fund.",institutionString:null,institution:null},{id:"172009",title:"Dr.",name:"Fatma Deniz",middleName:null,surname:"Uzuner",slug:"fatma-deniz-uzuner",fullName:"Fatma Deniz Uzuner",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/172009/images/7122_n.jpg",biography:"Dr. Deniz Uzuner was born in 1969 in Kocaeli-TURKEY. After graduating from TED Ankara College in 1986, she attended the Hacettepe University, Faculty of Dentistry in Ankara. \nIn 1993 she attended the Gazi University, Faculty of Dentistry, Department of Orthodontics for her PhD education. After finishing the PhD education, she worked as orthodontist in Ankara Dental Hospital under the Turkish Government, Ministry of Health and in a special Orthodontic Clinic till 2011. Between 2011 and 2016, Dr. Deniz Uzuner worked as a specialist in the Department of Orthodontics, Faculty of Dentistry, Gazi University in Ankara/Turkey. In 2016, she was appointed associate professor. Dr. Deniz Uzuner has authored 23 Journal Papers, 3 Book Chapters and has had 39 oral/poster presentations. She is a member of the Turkish Orthodontic Society. Her knowledge of English is at an advanced level.",institutionString:null,institution:null},{id:"332914",title:"Dr.",name:"Muhammad Saad",middleName:null,surname:"Shaikh",slug:"muhammad-saad-shaikh",fullName:"Muhammad Saad Shaikh",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Jinnah Sindh Medical University",country:{name:"Pakistan"}}},{id:"315775",title:"Dr.",name:"Feng",middleName:null,surname:"Luo",slug:"feng-luo",fullName:"Feng Luo",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Sichuan University",country:{name:"China"}}},{id:"423519",title:"Dr.",name:"Sizakele",middleName:null,surname:"Ngwenya",slug:"sizakele-ngwenya",fullName:"Sizakele Ngwenya",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of the Witwatersrand",country:{name:"South Africa"}}},{id:"419270",title:"Dr.",name:"Ann",middleName:null,surname:"Chianchitlert",slug:"ann-chianchitlert",fullName:"Ann Chianchitlert",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Walailak University",country:{name:"Thailand"}}},{id:"419271",title:"Dr.",name:"Diane",middleName:null,surname:"Selvido",slug:"diane-selvido",fullName:"Diane Selvido",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Walailak University",country:{name:"Thailand"}}},{id:"419272",title:"Dr.",name:"Irin",middleName:null,surname:"Sirisoontorn",slug:"irin-sirisoontorn",fullName:"Irin Sirisoontorn",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Walailak University",country:{name:"Thailand"}}},{id:"355660",title:"Dr.",name:"Anitha",middleName:null,surname:"Mani",slug:"anitha-mani",fullName:"Anitha Mani",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"SRM Dental College",country:{name:"India"}}},{id:"355612",title:"Dr.",name:"Janani",middleName:null,surname:"Karthikeyan",slug:"janani-karthikeyan",fullName:"Janani Karthikeyan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"SRM Dental College",country:{name:"India"}}},{id:"334400",title:"Dr.",name:"Suvetha",middleName:null,surname:"Siva",slug:"suvetha-siva",fullName:"Suvetha Siva",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"SRM Dental College",country:{name:"India"}}}]}},subseries:{item:{id:"93",type:"subseries",title:"Inclusivity and Social Equity",keywords:"Social contract, SDG, Human rights, Inclusiveness, Equity, Democracy, Personal learning, Collaboration, Glocalization",scope:"