\r\n\t1. To draw spotlight on recent studies and research concerned with the regeneration process in animal kingdom and models with emphasis on the cellular origins of regeneration.
\r\n\t2. Then, we will be dealing with the reasons for the differences in the regenerative capacity of animals on many levels, including the molecular mechanism, gene expression, epigenetic regulation, common elements affecting regeneration and comparing their contributions to regeneration.
\r\n\t3. To provide new insights into how to promote regeneration in mammals.
The reader may wonder why this chapter is part of a book about the pharynx. Although Beethoven had no problem with his pharynx, he did have problems with his ears and his gastrointestinal tract at both ends of the pharynx. The reason this is relevant is that new insights have come to light from information not available prior to this century. This has allowed a better picture of a problem that has been poorly understood for many years.
The pharynx, the incredible rendezvous site of gas, liquid, and solids, is connected in its superior aspect, or nasopharynx, to the ear
Many things can impede the eustachian tube from opening. These include viral upper respiratory infections, such as the common cld, nasal allergies, and sinus infections. These cause swelling of the eustachian tube opening, preventing it from opening properly. These can be treated by decongestants, antihistamines, nasal steroids, and antibiotics. Adenoid hypertrophy or enlargement can block air getting into the ear and can be treated by surgery or adenoidectomy. Tumors, such as nasopharyngeal carcinoma that is common in people of oriental origin, can be treated by surgery, radiation, and chemotherapy.
In cases of chronic eustachian tube dysfunction that has not responded to conservative measures, fluid can be drained from the middle ear by means of a hole or myringotomy made in the tympanic membrane or ear drum. If the eustachian tube remains occluded, however, fluid will re-accumulate, because the tympanic membrane will heal in a few days. This will necessitate placement of a small tube through the tympanic membrane or tympanostomy, to allow air to enter the middle ear space so the fluid can reabsorb. In recent years, a new technique called eustachian tube dilation has been performed from either the middle ear [2] or the nasopharynx [3], to restore normal eustachian tube function.
Beethoven had no problem with his eustachian tube, but he did have hearing loss, chronic gastrointestinal problems, intermittent pain in his extremities, depression, and alcohol dependence. There are many opinions regarding the etiology of Ludvig van Beethoven’s hearing loss. This is due to lack of confirmatory evidence by present techniques such as hearing tests, radiological and blood studies. His overall medical history was also complex with many symptoms that lead to conflicting diagnosis. Two papers demonstrate this sharp difference of opinion that can be formed even about the same diagnosis.
One paper examined three fragments of what was felt to be “nearly with certainly” Beethoven’s skull bone that did not show signs of Paget’s disease and emphasized that “it must therefore be concluded that Beethoven’s deafness was not caused by Paget’s Osteitis Deformans” [4]. The other paper stated, thus Paget’s disease, complicated by hyperparathyroidism, gout, and attempts to find relief of symptoms through the use of alcohol, quinine, and possibly salicylates, can explain virtually all of Beethoven’s medical problems [5]. The title of the latter included: “A Pathologist Sounds a final Note.” Obviously, there is no final note sounded, given the opposite opinions formed by these authors. A major problem is the approach that physicians have used. In their search for a diagnosis, they try to fit Beethoven’s multiple symptoms with a cause of hearing loss that they know little about and do not have personal experience with. This contrasts with the approach of someone familiar with causes of hearing loss making a diagnosis and then seeing if Beethoven’s other problems can be explained by this diagnosis. Relevant literature regarding his hearing loss was critically examined and felt not to explain his loss. It was then discovered that by reexamining a previously considered diagnosis with current information, a diagnosis could be made that explained not only his hearing loss, but his other symptoms as well. This satisfied Ockham’s razor, which is a principle of parsimony that postulates that among competing theories, the hypothesis with the fewest assumptions is the one best selected [6]. Although this principal does not apply in all cases where there are multiple symptoms, it does work here.
An extensive review of the musical and medical history of Beethoven’s life was done as part of a master’s degree in music history and literature at the University of Utah School of Music and is published in The Laryngoscope [7]. Literature subsequent to the publishing of that paper has also been critically examined to complete this chapter. All diagnoses of Beethoven’s deafness previously considered are not reviewed in this chapter due to length constraints, but attention is given to those most compelling.
Although confirmatory evidence is not available, the history of his hearing loss is, available and reveals much regarding it. At 27 years of age, Beethoven first noticed a hearing problem with ringing in his ear and became aware that he missed words and phrases. He confessed this to a childhood friend and physician in a letter. He said, “for the last several years my hearing has grown weaker and weaker-I cannot hear the high notes of instruments or voices-I can hear sounds, but I cannot make out the words” [8]. His loss slowly and progressively got worse so that he stopped playing the piano in 1815. In 1822, he had to stop conducting. What does the history of his hearing loss tell us? First, it was slowly progressive over a period of years. Second, it involved the high frequencies, at least initially, and third, he had reduced discrimination. Reduced discrimination is often seen in individuals that have hearing loss in the high frequencies. This causes them to miss the consonant sounds of words, because consonant sounds involve high frequencies. They hear words, but do not understand them, because they hear the vowels that are largely composed of lower tones, but not the high-tone consonants that separate the vowels.
One of the popular theories regarding Beethoven’s deafness is that of otosclerosis [9]. This is a disease that causes a slowly progressive loss and often begins in the teens or twenties like that experienced by Beethoven. However, people with otosclerosis usually do not have difficulty understanding words when the sounds are sufficiently loud. In other words, otosclerosis is usually associated with good discrimination. It is also inherited, and although it can skip several generations, it is striking that there is no history of hearing loss in Beethoven’s musical family. The most significant feature against otosclerosis is that a close examination of his temporal bone, including the middle ear, at the time of his death, found no evidence of otosclerotic foci. These are white plaques that would have been easily seen by the naked eye. These would certainly have been present given the many years of his loss before death.
Autoimmune hearing loss has been described in association with autoimmune bowel disease, and since Beethoven had gastrointestinal problems, his hearing loss might be autoimmune [10, 11]. However, autoimmune hearing loss usually progresses rapidly over weeks or months often with accompanying episodes of vertigo. A review of the literature did not find any cases of autoimmune loss with such a slow progression like Beethoven’s. In addition, autoimmune bowel disease is invariably accompanied by bloody diarrhea. Beethoven’s loss was slowly progressive and lacked vertigo, and no bloody diarrhea was ever mentioned. At his autopsy, there were no adhesions, strictures, or perforations in the bowel that are seen with autoimmune bowel disease. This diagnosis therefore does not fit.
Another diagnosis suggested by a prominent otologist is acquired syphilis, because of the shrunken cochlear nerves found at autopsy [12]. However, none of Beethoven’s 17 physicians considered the diagnosis of syphilis, and evaluation of Beethoven’s hair and bone samples in 2000 and 2005 showed no evidence of mercury [13, 14], which was used to treat syphilis in his era. Congenital syphilis is also not a valid consideration, because even though Beethoven’s father was an alcoholic, there is no evidence that he was sexually promiscuous. Beethoven also lacked any of the accompanying features of congenital syphilis such as skin rash, nasal discharge, ulcers of the nose and palate, bony deformities, corneal scarring, or dental abnormalities.
Lead poisoning has been previously considered to be the cause of Beethoven’s hearing loss, but has been dismissed because he lacked wrist drop, or weakness of the extensor muscles that elevate the wrist. This is invariably present with classic lead poisoning. This classic lead toxicity, however, usually occurs with exposure to high lead levels over a few years’ time. Those with low-level exposure over a longer time have mood disturbances, abnormal liver and kidney function, gastrointestinal disturbances, and pain and tingling in the hands and feet. Elevated levels of lead were found in Beethoven’s hair (see Figure 1) and deep in the bone, consistent with exposure over a long period of time [13, 14]. This constellation of symptoms was described in a group of 151 patients in Latvia [15] and was similar to those experienced by Beethoven. It is important to note that a black lead line on gingival tissues, seen with classic lead poisoning, nor disturbance in the sense of taste, was reported neither in these patients nor by Beethoven.
X-ray fluorescence intensity levels in Beethoven’s hair compared with normal levels.
One of the amazing functions of the pharynx is the sense of taste. Taste buds for sweet, sour, bitter, and salt are found in the oral cavity and the or-pharynx, and even in the hypopharynx. The sensation of taste or gustatory sensation is transmitted by way of both the lingual nerve
A recent article discusses the many medical symptoms Beethoven had during his life [16]. Although lead can account for several symptoms, such as abdominal pain or colic, it is also possible that he had irritable bowel syndrome to explain his gastrointestinal problems, and the pain in his hands and feet could have represented a rheumatological syndrome. Cirrhosis and chronic pancreatitis seen at death were attributable to his alcohol consumption, but lead could also have contributed to the cirrhosis. His kidney damage could have been caused by lead, but also by pyelonephritis.
The provocative article written in 2017 mentioned in the introduction [5] deserves close scrutiny as it is well written by Oiseth, a pathologist. He disagrees with the original finding of prior pathologists [4]. There appear to be a number of flaws with his approach, which is largely based on the findings of a thickened skull on gross examination at the autopsy, which is consistent with Paget’s disease. However, as he himself wrote, there are other causes of a thickened skull. One of these is hyperparathyroidism which the author suggests he had due to chronic renal disease. A gross examination is the initial examination to draw up a differential diagnosis, and then, the microscopic examination is used to confirm the diagnosis. The prior pathologists did a microscopic exam and found no evidence of Paget’s disease. Oiseth dismisses this with the fact that Paget’s disease of the skull is not uniform and may undergo remodeling, so normal bone may be seen in the final phase of the disease. This is something those who did the original exam were well aware of, but perhaps they did get a sample that lacked microscopic evidence of Paget’s disease. This seems extremely unlikely, as they examined three large pieces of bone from the parietal and occipital areas of the skull. However, Oiseth fails to point out that a gross exam was also done on the middle ear, which was found to be normal. It would seem likely that microscopic fractures, fixation of the stapes footplate, or fissures of the otic capsule would have been seen as sequelae of the active process, since the hearing loss that is associated with Paget’s usually involves the middle ear. It is also likely that an irregular surface of the temporal bone would have been noted from prior active disease.
Oiseth admits that lead poisoning cannot be dismissed entirely, but then makes the same error as other authors that have dismissed lead poisoning, by noting the lack of other neurologic manifestations. Although the article in The Laryngoscope was cited by him [4], he apparently read only the title and did not even read the abstract that states that chronic low-level lead exposure like Beethoven had does not result in motor deficits that are usually seen with acute lead poisoning. This also explains why the acoustic nerve, a sensory nerve, was shrunken with lead damage, but the facial nerve, a motor nerve, was left untouched. Beethoven’s loss started in his twenties, whereas only 3% of patients with Paget’s disease are under 40.
He also mentions that Beethoven had recruitment, which is an abnormal sensitivity to loud sounds, due to impingement of Paget’s disease on the cochlear nerve as evidence of a sensorineural loss and not of otosclerosis. By this, he demonstrates his lack of understanding of the term sensorineural, which is an inclusive term comprising a loss from either the nerve, the cochlea, or both. Patients with hearing loss from the cochlear nerve do not have recruitment, as this is a symptom of disease in the cochlea itself. Again this underlies the difficulty of someone not familiar with hearing loss to conjecture as to its causes. Recruitment is fully discussed in the article in The Laryngoscope [7]. Therefore, it is very unlikely that Paget’s disease caused Beethoven’s hearing loss.
Although lead can come from a variety of sources such as dishes, lead-lined wine flasks, lead crystal, or mineral water at spas, Beethoven’s expenditures for wine were excessive [17]. He drank wine at every meal. Although Beethoven’s personal secretary never mentioned that he had a problem with alcohol, his physicians were well aware of it. His secretary did say that “Beethoven preferred wine of the heights around buda to every other” [18]. Lead was added to this inexpensive wine to improve the flavor. In addition to his father, Beethoven’s family had a history of alcohol abuse. It is interesting that George Frederic Handel also had lead poisoning [19].
A fascinating patient in Italy was reported in 2021 that dramatically emphasized the relationship that lead has to Beethoven’s deafness [20]. A 64-year-old woman presented with a slowly progressive hearing loss. She also complained of abdominal pain and tingling in her upper extremities like Beethoven. An audiogram showed a moderately severe hearing loss. Elevated levels of lead were found in her blood and urine. An examination of possible lead sources revealed that she used a cooking pan with a worn ceramic surface that released lead into her food. She underwent chelation with ethylenediaminetetraacetic acid disodium salt which was injected into her to bind to the lead and allow it to be excreted from the body. After 1 year, her symptoms had all resolved, and her hearing was stabilized.
Hearing loss can be very debilitating. This was especially true with Beethoven whose livelihood was dependent on his hearing. His loss caused him to be depressed, and at one time, the depression became so severe that he considered taking his own life [8]. Poignant is the picture of him when his ninth symphony was first performed. He was the honorary conductor and faced the orchestra. When the performance was finished, the contralto soloist had to turn him around to face the audience in order for him to see their applause, as he could not hear it [21]. It also significantly influenced his relationships with others. He was largely a solitary figure. He would very much have liked to have been married, but women generally found him eccentric. One cannot comprehend the depth of sorrow that this disability engendered in this gifted man.
On long walks that he liked to take, he would hear music in his head and write it down on a sketch pad. He did not just hear the melody, and later harmonize the parts, he heard it in its entirety [22]. With his loss of hearing, he was not able to check his music on the piano, but his superb ability to hear intervals in his head left his ability to compose unaffected. His music has been held in high esteem for over two centuries and continues to inspire millions. He recognized the great gift that he had to give to mankind and was consummately successful in doing so. Although Beethoven’s hearing loss did not affect the quality of his music, his Eroica and 5th Symphony, the opera Fidelio, and the Egmont and Coriolan overtures reflect his heroic resolve and determination to conquer his suicidal thoughts and go on creating [23]. This heroic attitude is also heard in the Waldstein and Appassionata Sonatas, three string quartets opus 59, and the oratorio Christ on the Mount of Olives.
The best current evidence is that the most likely cause of Beethoven’s hearing loss was his consumption of wine tainted with lead. Fortunately, it did not affect his ability to compose.
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\n\nIntechOpen is dedicated to ensuring the long-term preservation and availability of the scholarly research it publishes.
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Therefore, it is necessary to evaluate the effectiveness of determining the age of deposition using zircon age data. We carried out U–Pb dating of detrital zircons from sandstone at eight sites in the Cretaceous Shimanto accretionary complex on Kii Peninsula, Japan, with the aim of evaluating the accuracy of U–Pb zircon ages as indicators of the depositional age of sedimentary rocks by comparing zircon ages with radiolarian ages. Our results reveal zircons of late Cretaceous age, and the youngest peak ages are in good agreement with depositional ages inferred from radiolarian fossils. In addition, the youngest peak ages become younger as tectono-structurally downwards, and this tendency is clearer for the zircon ages than for the radiolarian ages. These results indicate that newly crystalized zircons were continuously supplied to the sediment by constant igneous activity during the late Cretaceous and that zircon ages provide remarkably useful information for determining the age of deposition in the Cretaceous Shimanto accretionary complex.",book:{id:"5615",slug:"evolutionary-models-of-convergent-margins-origin-of-their-diversity",title:"Evolutionary Models of Convergent Margins",fullTitle:"Evolutionary Models of Convergent Margins - Origin of Their Diversity"},signatures:"Tetsuya Tokiwa, Makoto Takeuchi, Yusuke Shimura, Kazuho Shobu,\nAkari Ota, Koshi Yamamoto and Hiroshi Mori",authors:[{id:"150531",title:"Dr.",name:"Koshi",middleName:null,surname:"Yamamoto",slug:"koshi-yamamoto",fullName:"Koshi Yamamoto"},{id:"194144",title:"Dr.",name:"Tetsuya",middleName:null,surname:"Tokiwa",slug:"tetsuya-tokiwa",fullName:"Tetsuya Tokiwa"},{id:"204259",title:"Dr.",name:"Makoto",middleName:null,surname:"Takeuchi",slug:"makoto-takeuchi",fullName:"Makoto Takeuchi"},{id:"204260",title:"Mr.",name:"Yusuke",middleName:null,surname:"Shimura",slug:"yusuke-shimura",fullName:"Yusuke Shimura"},{id:"204261",title:"Mr.",name:"Kazuho",middleName:null,surname:"Shobu",slug:"kazuho-shobu",fullName:"Kazuho Shobu"},{id:"204262",title:"Ms.",name:"Akari",middleName:null,surname:"Ota",slug:"akari-ota",fullName:"Akari Ota"},{id:"204263",title:"Dr.",name:"Hiroshi",middleName:null,surname:"Mori",slug:"hiroshi-mori",fullName:"Hiroshi Mori"}]},{id:"55296",doi:"10.5772/68112",title:"Alteration Reaction and Mass Transfer via Fluids with Progress of Fracturing along the Median Tectonic Line, Mie Prefecture, Southwest Japan",slug:"alteration-reaction-and-mass-transfer-via-fluids-with-progress-of-fracturing-along-the-median-tecton",totalDownloads:1218,totalCrossrefCites:1,totalDimensionsCites:8,abstract:"We have analyzed mass transfer in the cataclasite samples collected from the Median Tectonic Line, southwest Japan, in which the degree of fracturing is well correlated with the bulk rock chemical compositions determined by the X-ray fluorescence (XRF) analysis. The results of “isocon” analysis indicate not only a large volume increase up to 110% but also the two-stage mass transfer during cataclasis. At the first stage from the very weakly to weakly fractured rocks, the weight percents of SiO2, Na2O, and K2O increase, while those of TiO2, FeO, MnO, MgO, and CaO decrease. At the second stage from the weakly to moderately and strongly fractured rocks, the trend of mass transfer is reversed. The principal component analysis reveals that the variation of chemical compositions in the cataclasite samples can be mostly interpreted by the mass transfer via fluids and by the difference in chemical composition in the protolith rocks to lesser degree. Finally, the changes in the modal composition of minerals with increasing cataclasis analyzed by the X-ray diffraction (XRD) with the aid of “RockJock” software clearly elucidate that the mass transfer of chemical elements was caused by dissolution and precipitation of minerals via fluids in the cataclasite samples.",book:{id:"5615",slug:"evolutionary-models-of-convergent-margins-origin-of-their-diversity",title:"Evolutionary Models of Convergent Margins",fullTitle:"Evolutionary Models of Convergent Margins - Origin of Their Diversity"},signatures:"Yumi Kaneko, Toru Takeshita, Yuto Watanabe, Norio Shigematsu\nand Ko‐Ichiro Fujimoto",authors:[{id:"194157",title:"M.Sc.",name:"Yumi",middleName:null,surname:"Kaneko",slug:"yumi-kaneko",fullName:"Yumi Kaneko"},{id:"204607",title:"Prof.",name:"Toru",middleName:null,surname:"Takeshita",slug:"toru-takeshita",fullName:"Toru Takeshita"},{id:"204608",title:"MSc.",name:"Yuto",middleName:null,surname:"Watanabe",slug:"yuto-watanabe",fullName:"Yuto Watanabe"},{id:"204609",title:"Dr.",name:"Norio",middleName:null,surname:"Shigematsu",slug:"norio-shigematsu",fullName:"Norio Shigematsu"},{id:"204610",title:"Dr.",name:"Ko-Ichiro",middleName:null,surname:"Fujimoto",slug:"ko-ichiro-fujimoto",fullName:"Ko-Ichiro Fujimoto"}]},{id:"54870",doi:"10.5772/67559",title:"Deposition and Deformation of Modern Accretionary-Type Forearc Basins: Linking Basin Formation and Accretionary Wedge Growth",slug:"deposition-and-deformation-of-modern-accretionary-type-forearc-basins-linking-basin-formation-and-ac",totalDownloads:1773,totalCrossrefCites:2,totalDimensionsCites:4,abstract:"Since a comprehensive review of forearc basins was published by Dickinson more than 20 years ago, a significant amount of new data about them have been published. These recent studies revealed details of depositional and deformation styles in the forearc basins, suggesting the formation processes were not unique. In this chapter, we reviewed modern forearc basins to understand how is the basin stratigraphy related with growth of accretionary wedges. The results indicate forearc basin can be classified into two (single‐ and two‐wedge models) plus one (strike‐slip model): (1) the single‐wedge model which is characterized by landward tilting of the basin strata ascribed to asymmetrical doubly vergent (single‐vergent) uplift of the outer arc high with forethrusts (seaward‐vergent thrusts in the pro‐wedge); (2) the two‐wedge model which is marked by contractional deformation caused by symmetrical doubly vergent uplift of the wedge with forethrusts in the prowedge and back‐thrusts (landward‐vergent thrusts) in the retro‐wedge; and (3) the strike‐slip model which is an additional one being represented by transpressional and/or transtensional deformations due to oblique subduction. We speculate that these models spatially and temporally depend on material fluxes at the plate interfaces that affect geometry and mechanical strength of backstops.",book:{id:"5615",slug:"evolutionary-models-of-convergent-margins-origin-of-their-diversity",title:"Evolutionary Models of Convergent Margins",fullTitle:"Evolutionary Models of Convergent Margins - Origin of Their Diversity"},signatures:"Atsushi Noda and Ayumu Miyakawa",authors:[{id:"161716",title:"Dr.",name:"Atsushi",middleName:null,surname:"Noda",slug:"atsushi-noda",fullName:"Atsushi Noda"},{id:"204603",title:"Dr.",name:"Ayumu",middleName:null,surname:"Miyakawa",slug:"ayumu-miyakawa",fullName:"Ayumu Miyakawa"}]},{id:"54596",doi:"10.5772/67960",title:"Paleomagnetic Studies on Miocene Sequences of Hokutan and Tottori Groups in Southwest Japan: Implications for Middle Miocene Rotational Movement of Southwest Japan Block Associated with the Japan Sea Opening",slug:"paleomagnetic-studies-on-miocene-sequences-of-hokutan-and-tottori-groups-in-southwest-japan-implicat",totalDownloads:1524,totalCrossrefCites:1,totalDimensionsCites:3,abstract:"Miocene sequences composed of volcanic rocks and overlying marine sediments distributing at the Japan Sea side of Southwest Japan have been considered to form related to the rifting and subsequent spreading of the Japan Sea back-arc basin in Miocene time. We performed paleomagnetic investigations on the sequences in the eastern San’in district, the Hokutan and Tottori Groups. Paleomagnetic analyses on samples from 33 sites indicated that characteristic magnetic components from five sites of volcanic rocks in the Hokutan Group and from four sites of marine sediments in the Tottori Group were regarded as primary components. An obtained paleomagnetic direction of the volcanic rocks has an easterly deflected declination (D = 23.9° ± 20.2°), while that of the marine sediments shows no significant deflection in declination (D = 17.8° ± 19.1°). Through the comparison with paleomagnetic data from the Miocene sequences in Southwest Japan, it is suggested that magnetic polarities of the volcanic and sedimentary sequences are assigned to C5Cn and C5Br-C5Bn, respectively, and that the eastern San’in district suffered a clockwise rotation of 24° at around 16 Ma after the early Miocene volcanic activity and before the middle Miocene marine transgression in the whole clockwise rotation process of Southwest Japan related to the Japan Sea opening.",book:{id:"5615",slug:"evolutionary-models-of-convergent-margins-origin-of-their-diversity",title:"Evolutionary Models of Convergent Margins",fullTitle:"Evolutionary Models of Convergent Margins - Origin of Their Diversity"},signatures:"Naoto Ishikawa, Takashi Suzuki and Shiro Ishida",authors:[{id:"194180",title:"Dr.",name:"Naoto",middleName:null,surname:"Ishikawa",slug:"naoto-ishikawa",fullName:"Naoto Ishikawa"},{id:"204504",title:"Dr.",name:"Takashi",middleName:null,surname:"Suzuki",slug:"takashi-suzuki",fullName:"Takashi Suzuki"},{id:"204505",title:"Prof.",name:"Shiro",middleName:null,surname:"Ishida",slug:"shiro-ishida",fullName:"Shiro Ishida"}]},{id:"54454",doi:"10.5772/67669",title:"Structural Features Along the Median Tectonic Line in Southwest Japan: An Example of Multiphase Deformation on an Arc‐Bisecting Fault",slug:"structural-features-along-the-median-tectonic-line-in-southwest-japan-an-example-of-multiphase-defor",totalDownloads:1280,totalCrossrefCites:1,totalDimensionsCites:2,abstract:"A geological survey for the Late Cretaceous Izumi Group distributed on the Median Tectonic Line (MTL) active fault system in the central part of southwestern Japan has revealed varied deformation styles. Among the confined deformation zones found in the western and central parts of the study area, some are located far from the active trace of the MTL (Negoro Fault), at distances of up to 300–350 m. Such kink zones may have been generated during a contraction phase of the MTL from the end of the Pliocene to the early Pleistocene. We identified clear active foldings in a narrow zone sandwiched between a north dextral and a south reverse active fault. Western and eastern upheavals of the crustal sliver show ridge and domal active morphologies, respectively. Structural analysis was extended to the north of the MTL, where the Izumi Group has suffered multiphase deformation since the Cretaceous. The phase stripping method was introduced to extract the neotectonic trend, which successfully delineated complicated deformation zones related to the morphological divergence of the MTL active fault system.",book:{id:"5615",slug:"evolutionary-models-of-convergent-margins-origin-of-their-diversity",title:"Evolutionary Models of Convergent Margins",fullTitle:"Evolutionary Models of Convergent Margins - Origin of Their Diversity"},signatures:"Yasuto Itoh and Tomotaka Iwata",authors:[{id:"46893",title:"Dr.",name:"Yasuto",middleName:null,surname:"Itoh",slug:"yasuto-itoh",fullName:"Yasuto Itoh"},{id:"203882",title:"Prof.",name:"Tomotaka",middleName:null,surname:"Iwata",slug:"tomotaka-iwata",fullName:"Tomotaka Iwata"}]}],mostDownloadedChaptersLast30Days:[{id:"54840",title:"Effectiveness for Determination of Depositional Age by Detrital Zircon U–Pb Age in the Cretaceous Shimanto Accretionary Complex of Japan",slug:"effectiveness-for-determination-of-depositional-age-by-detrital-zircon-u-pb-age-in-the-cretaceous-sh",totalDownloads:1473,totalCrossrefCites:8,totalDimensionsCites:13,abstract:"Detrital zircon U–Pb ages indicate the crystallization age. Therefore, it is necessary to evaluate the effectiveness of determining the age of deposition using zircon age data. We carried out U–Pb dating of detrital zircons from sandstone at eight sites in the Cretaceous Shimanto accretionary complex on Kii Peninsula, Japan, with the aim of evaluating the accuracy of U–Pb zircon ages as indicators of the depositional age of sedimentary rocks by comparing zircon ages with radiolarian ages. Our results reveal zircons of late Cretaceous age, and the youngest peak ages are in good agreement with depositional ages inferred from radiolarian fossils. In addition, the youngest peak ages become younger as tectono-structurally downwards, and this tendency is clearer for the zircon ages than for the radiolarian ages. These results indicate that newly crystalized zircons were continuously supplied to the sediment by constant igneous activity during the late Cretaceous and that zircon ages provide remarkably useful information for determining the age of deposition in the Cretaceous Shimanto accretionary complex.",book:{id:"5615",slug:"evolutionary-models-of-convergent-margins-origin-of-their-diversity",title:"Evolutionary Models of Convergent Margins",fullTitle:"Evolutionary Models of Convergent Margins - Origin of Their Diversity"},signatures:"Tetsuya Tokiwa, Makoto Takeuchi, Yusuke Shimura, Kazuho Shobu,\nAkari Ota, Koshi Yamamoto and Hiroshi Mori",authors:[{id:"150531",title:"Dr.",name:"Koshi",middleName:null,surname:"Yamamoto",slug:"koshi-yamamoto",fullName:"Koshi Yamamoto"},{id:"194144",title:"Dr.",name:"Tetsuya",middleName:null,surname:"Tokiwa",slug:"tetsuya-tokiwa",fullName:"Tetsuya Tokiwa"},{id:"204259",title:"Dr.",name:"Makoto",middleName:null,surname:"Takeuchi",slug:"makoto-takeuchi",fullName:"Makoto Takeuchi"},{id:"204260",title:"Mr.",name:"Yusuke",middleName:null,surname:"Shimura",slug:"yusuke-shimura",fullName:"Yusuke Shimura"},{id:"204261",title:"Mr.",name:"Kazuho",middleName:null,surname:"Shobu",slug:"kazuho-shobu",fullName:"Kazuho Shobu"},{id:"204262",title:"Ms.",name:"Akari",middleName:null,surname:"Ota",slug:"akari-ota",fullName:"Akari Ota"},{id:"204263",title:"Dr.",name:"Hiroshi",middleName:null,surname:"Mori",slug:"hiroshi-mori",fullName:"Hiroshi Mori"}]},{id:"54341",title:"Oki-Dozen Dike Swarm: Effect of the Regional Stress Field on Volcano-Tectonic Orientations",slug:"oki-dozen-dike-swarm-effect-of-the-regional-stress-field-on-volcano-tectonic-orientations",totalDownloads:1504,totalCrossrefCites:0,totalDimensionsCites:1,abstract:"This article presents new field, geochronological, and geochemical data for the Late Miocene Oki-dozen dike swarm (ODS), southwest Japan. This swarm is part of a volcanic suite comprising mafic and silicic dikes, sills, and pyroclastic cones from which we obtained structural measurements at a various genetic orders and scales. The mafic magmas generated three dike swarms with dikes oriented to NW-SE, N-S, and NE-SW. In comparison, the silicic intrusions do not have a preferred orientation but instead appear to radiate from the center of the volcanic suite. Comparison of the maximum thickness of 37 dikes with SiO2 content (wt%) yielded a critical thickness (T\ncr\n) value of T\ncr\n = 0.2 × (SiO2 − 40). These data indicate that the orientations of dikes were controlled by the magnitude of dike tip pressure and magma overpressure, both of which positively correlate with SiO2 concentrations. The silicic units yield estimated pressures (up to 15–60 MPa) that are large enough to have counteracted the regional stress field, whereas the mafic dike swarm only yielded lower pressures. This result suggests that comparative analysis at a range of scales is essential for the accurate determination on the tectonic stress field by igneous rocks.",book:{id:"5615",slug:"evolutionary-models-of-convergent-margins-origin-of-their-diversity",title:"Evolutionary Models of Convergent Margins",fullTitle:"Evolutionary Models of Convergent Margins - Origin of Their Diversity"},signatures:"Daisuke Miura, Kiyoshi Toshida, Ken-ichi Arai, Takeshi Wachi and\nYutaka Wada",authors:[{id:"194873",title:"Dr.",name:"Daisuke",middleName:null,surname:"Miura",slug:"daisuke-miura",fullName:"Daisuke Miura"},{id:"203853",title:"Mr.",name:"Kiyoshi",middleName:null,surname:"Toshida",slug:"kiyoshi-toshida",fullName:"Kiyoshi Toshida"},{id:"203854",title:"Mr.",name:"Ken'Ichi",middleName:null,surname:"Arai",slug:"ken'ichi-arai",fullName:"Ken'Ichi Arai"},{id:"203856",title:"Prof.",name:"Yutaka",middleName:null,surname:"Wada",slug:"yutaka-wada",fullName:"Yutaka Wada"},{id:"204024",title:"Mr.",name:"Takeshi",middleName:null,surname:"Wachi",slug:"takeshi-wachi",fullName:"Takeshi Wachi"}]},{id:"54596",title:"Paleomagnetic Studies on Miocene Sequences of Hokutan and Tottori Groups in Southwest Japan: Implications for Middle Miocene Rotational Movement of Southwest Japan Block Associated with the Japan Sea Opening",slug:"paleomagnetic-studies-on-miocene-sequences-of-hokutan-and-tottori-groups-in-southwest-japan-implicat",totalDownloads:1524,totalCrossrefCites:1,totalDimensionsCites:3,abstract:"Miocene sequences composed of volcanic rocks and overlying marine sediments distributing at the Japan Sea side of Southwest Japan have been considered to form related to the rifting and subsequent spreading of the Japan Sea back-arc basin in Miocene time. We performed paleomagnetic investigations on the sequences in the eastern San’in district, the Hokutan and Tottori Groups. Paleomagnetic analyses on samples from 33 sites indicated that characteristic magnetic components from five sites of volcanic rocks in the Hokutan Group and from four sites of marine sediments in the Tottori Group were regarded as primary components. An obtained paleomagnetic direction of the volcanic rocks has an easterly deflected declination (D = 23.9° ± 20.2°), while that of the marine sediments shows no significant deflection in declination (D = 17.8° ± 19.1°). Through the comparison with paleomagnetic data from the Miocene sequences in Southwest Japan, it is suggested that magnetic polarities of the volcanic and sedimentary sequences are assigned to C5Cn and C5Br-C5Bn, respectively, and that the eastern San’in district suffered a clockwise rotation of 24° at around 16 Ma after the early Miocene volcanic activity and before the middle Miocene marine transgression in the whole clockwise rotation process of Southwest Japan related to the Japan Sea opening.",book:{id:"5615",slug:"evolutionary-models-of-convergent-margins-origin-of-their-diversity",title:"Evolutionary Models of Convergent Margins",fullTitle:"Evolutionary Models of Convergent Margins - Origin of Their Diversity"},signatures:"Naoto Ishikawa, Takashi Suzuki and Shiro Ishida",authors:[{id:"194180",title:"Dr.",name:"Naoto",middleName:null,surname:"Ishikawa",slug:"naoto-ishikawa",fullName:"Naoto Ishikawa"},{id:"204504",title:"Dr.",name:"Takashi",middleName:null,surname:"Suzuki",slug:"takashi-suzuki",fullName:"Takashi Suzuki"},{id:"204505",title:"Prof.",name:"Shiro",middleName:null,surname:"Ishida",slug:"shiro-ishida",fullName:"Shiro Ishida"}]},{id:"55296",title:"Alteration Reaction and Mass Transfer via Fluids with Progress of Fracturing along the Median Tectonic Line, Mie Prefecture, Southwest Japan",slug:"alteration-reaction-and-mass-transfer-via-fluids-with-progress-of-fracturing-along-the-median-tecton",totalDownloads:1218,totalCrossrefCites:1,totalDimensionsCites:8,abstract:"We have analyzed mass transfer in the cataclasite samples collected from the Median Tectonic Line, southwest Japan, in which the degree of fracturing is well correlated with the bulk rock chemical compositions determined by the X-ray fluorescence (XRF) analysis. The results of “isocon” analysis indicate not only a large volume increase up to 110% but also the two-stage mass transfer during cataclasis. At the first stage from the very weakly to weakly fractured rocks, the weight percents of SiO2, Na2O, and K2O increase, while those of TiO2, FeO, MnO, MgO, and CaO decrease. At the second stage from the weakly to moderately and strongly fractured rocks, the trend of mass transfer is reversed. The principal component analysis reveals that the variation of chemical compositions in the cataclasite samples can be mostly interpreted by the mass transfer via fluids and by the difference in chemical composition in the protolith rocks to lesser degree. Finally, the changes in the modal composition of minerals with increasing cataclasis analyzed by the X-ray diffraction (XRD) with the aid of “RockJock” software clearly elucidate that the mass transfer of chemical elements was caused by dissolution and precipitation of minerals via fluids in the cataclasite samples.",book:{id:"5615",slug:"evolutionary-models-of-convergent-margins-origin-of-their-diversity",title:"Evolutionary Models of Convergent Margins",fullTitle:"Evolutionary Models of Convergent Margins - Origin of Their Diversity"},signatures:"Yumi Kaneko, Toru Takeshita, Yuto Watanabe, Norio Shigematsu\nand Ko‐Ichiro Fujimoto",authors:[{id:"194157",title:"M.Sc.",name:"Yumi",middleName:null,surname:"Kaneko",slug:"yumi-kaneko",fullName:"Yumi Kaneko"},{id:"204607",title:"Prof.",name:"Toru",middleName:null,surname:"Takeshita",slug:"toru-takeshita",fullName:"Toru Takeshita"},{id:"204608",title:"MSc.",name:"Yuto",middleName:null,surname:"Watanabe",slug:"yuto-watanabe",fullName:"Yuto Watanabe"},{id:"204609",title:"Dr.",name:"Norio",middleName:null,surname:"Shigematsu",slug:"norio-shigematsu",fullName:"Norio Shigematsu"},{id:"204610",title:"Dr.",name:"Ko-Ichiro",middleName:null,surname:"Fujimoto",slug:"ko-ichiro-fujimoto",fullName:"Ko-Ichiro Fujimoto"}]},{id:"54454",title:"Structural Features Along the Median Tectonic Line in Southwest Japan: An Example of Multiphase Deformation on an Arc‐Bisecting Fault",slug:"structural-features-along-the-median-tectonic-line-in-southwest-japan-an-example-of-multiphase-defor",totalDownloads:1280,totalCrossrefCites:1,totalDimensionsCites:2,abstract:"A geological survey for the Late Cretaceous Izumi Group distributed on the Median Tectonic Line (MTL) active fault system in the central part of southwestern Japan has revealed varied deformation styles. Among the confined deformation zones found in the western and central parts of the study area, some are located far from the active trace of the MTL (Negoro Fault), at distances of up to 300–350 m. Such kink zones may have been generated during a contraction phase of the MTL from the end of the Pliocene to the early Pleistocene. We identified clear active foldings in a narrow zone sandwiched between a north dextral and a south reverse active fault. Western and eastern upheavals of the crustal sliver show ridge and domal active morphologies, respectively. Structural analysis was extended to the north of the MTL, where the Izumi Group has suffered multiphase deformation since the Cretaceous. The phase stripping method was introduced to extract the neotectonic trend, which successfully delineated complicated deformation zones related to the morphological divergence of the MTL active fault system.",book:{id:"5615",slug:"evolutionary-models-of-convergent-margins-origin-of-their-diversity",title:"Evolutionary Models of Convergent Margins",fullTitle:"Evolutionary Models of Convergent Margins - Origin of Their Diversity"},signatures:"Yasuto Itoh and Tomotaka Iwata",authors:[{id:"46893",title:"Dr.",name:"Yasuto",middleName:null,surname:"Itoh",slug:"yasuto-itoh",fullName:"Yasuto Itoh"},{id:"203882",title:"Prof.",name:"Tomotaka",middleName:null,surname:"Iwata",slug:"tomotaka-iwata",fullName:"Tomotaka Iwata"}]}],onlineFirstChaptersFilter:{topicId:"657",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:89,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:32,numberOfPublishedChapters:318,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:106,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:5,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:15,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. 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Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:2,paginationItems:[{id:"1",title:"Oral Health",coverUrl:"https://cdn.intechopen.com/series_topics/covers/1.jpg",isOpenForSubmission:!0,editor:{id:"173955",title:"Prof.",name:"Sandra",middleName:null,surname:"Marinho",slug:"sandra-marinho",fullName:"Sandra Marinho",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRGYMQA4/Profile_Picture_2022-06-01T13:22:41.png",biography:"Dr. Sandra A. Marinho is an Associate Professor and Brazilian researcher at the State University of Paraíba (Universidade Estadual da Paraíba- UEPB), Campus VIII, located in Araruna, state of Paraíba since 2011. She holds a degree in Dentistry from the Federal University of Alfenas (UNIFAL), while her specialization and professional improvement in Stomatology took place at Hospital Heliopolis (São Paulo, SP). Her qualifications are: a specialist in Dental Imaging and Radiology, Master in Dentistry (Periodontics) from the University of São Paulo (FORP-USP, Ribeirão Preto, SP), and Doctor (Ph.D.) in Dentistry (Stomatology Clinic) from Hospital São Lucas of the Pontifical Catholic University of Rio Grande do Sul (HSL-PUCRS, Porto Alegre, RS). She held a postdoctoral internship at the Federal University from Jequitinhonha and Mucuri Valleys (UFVJM, Diamantina, MG). She is currently a member of the Brazilian Society for Dental Research (SBPqO) and the Brazilian Society of Stomatology and Pathology (SOBEP). Dr. Marinho's experience in Dentistry mainly covers the following subjects: oral diagnosis, oral radiology; oral medicine; lesions and oral infections; oral pathology, laser therapy and epidemiological studies.",institutionString:null,institution:{name:"State University of Paraíba",institutionURL:null,country:{name:"Brazil"}}},editorTwo:null,editorThree:null},{id:"2",title:"Prosthodontics and Implant Dentistry",coverUrl:"https://cdn.intechopen.com/series_topics/covers/2.jpg",isOpenForSubmission:!0,editor:{id:"179568",title:"Associate Prof.",name:"Wen Lin",middleName:null,surname:"Chai",slug:"wen-lin-chai",fullName:"Wen Lin Chai",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRHGAQA4/Profile_Picture_2022-05-23T14:31:12.png",biography:"Professor Dr. Chai Wen Lin is currently a lecturer at the Department of Restorative Dentistry, Faculty of Dentistry of the University of Malaya. She obtained a Master of Dental Science in 2006 and a Ph.D. in 2011. Her Ph.D. research work on the soft tissue-implant interface at the University of Sheffield has yielded several important publications in the key implant journals. She was awarded an Excellent Exchange Award by the University of Sheffield which gave her the opportunity to work at the famous Faculty of Dentistry of the University of Gothenburg, Sweden, under the tutelage of Prof. Peter Thomsen. In 2016, she was appointed as a visiting scholar at UCLA, USA, with attachment in Hospital Dentistry, and involvement in research work related to zirconia implant. In 2016, her contribution to dentistry was recognized by the Royal College of Surgeon of Edinburgh with her being awarded a Fellowship in Dental Surgery. She has authored numerous papers published both in local and international journals. She was the Editor of the Malaysian Dental Journal for several years. Her main research interests are implant-soft tissue interface, zirconia implant, photofunctionalization, 3D-oral mucosal model and pulpal regeneration.",institutionString:null,institution:{name:"University of Malaya",institutionURL:null,country:{name:"Malaysia"}}},editorTwo:{id:"479686",title:"Dr.",name:"Ghee Seong",middleName:null,surname:"Lim",slug:"ghee-seong-lim",fullName:"Ghee Seong Lim",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003ScjLZQAZ/Profile_Picture_2022-06-08T14:17:06.png",biography:"Assoc. Prof Dr. Lim Ghee Seong graduated with a Bachelor of Dental Surgery from University of Malaya, Kuala Lumpur in 2008. He then pursued his Master in Clinical Dentistry, specializing in Restorative Dentistry at Newcastle University, Newcastle, UK, where he graduated with distinction. He has also been awarded the International Training Fellowship (Restorative Dentistry) from the Royal College of Surgeons. His passion for teaching then led him to join the faculty of dentistry at University Malaya and he has since became a valuable lecturer and clinical specialist in the Department of Restorative Dentistry. He is currently the removable prosthodontic undergraduate year 3 coordinator, head of the undergraduate module on occlusion and a member of the multidisciplinary team for the TMD clinic. He has previous membership in the British Society for Restorative Dentistry, the Malaysian Association of Aesthetic Dentistry and he is currently a lifetime member of the Malaysian Association for Prosthodontics. Currently, he is also the examiner for the Restorative Specialty Membership Examinations, Royal College of Surgeons, England. He has authored and co-authored handful of both local and international journal articles. 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Currently, he is a professor of Orthodontics. He holds a Certificate of Advanced Study type A in Technology of Biomaterials used in Dentistry (1995); Certificate of Advanced Study type B in Dento-Facial Orthopaedics (1997) from the Faculty of Dental Surgery, University Denis Diderot-Paris VII, France; Diploma of Advanced Study (DESA) in Biocompatibility of Biomaterials from the Faculty of Medicine and Pharmacy of Casablanca (2002); Certificate of Clinical Occlusodontics from the Faculty of Dentistry of Casablanca (2004); University Diploma of Biostatistics and Perceptual Health Measurement from the Faculty of Medicine and Pharmacy of Casablanca (2011); and a University Diploma of Pedagogy of Odontological Sciences from the Faculty of Dentistry of Casablanca (2013). 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He has both an MS and Ph.D. in Biomedical Engineering. He was previously a research scientist at the University of California Los Angeles (UCLA) and visiting professor and researcher at the University of North Dakota. He is currently working in artificial intelligence and its applications in medical signal processing. In addition, he is using digital signal processing in medical imaging and speech processing. Dr. Asadpour has developed brain-computer interfacing algorithms and has published books, book chapters, and several journal and conference papers in this field and other areas of intelligent signal processing. He has also designed medical devices, including a laser Doppler monitoring system.",institutionString:"Kaiser Permanente Southern California",institution:null},{id:"169608",title:"Prof.",name:"Marian",middleName:null,surname:"Găiceanu",slug:"marian-gaiceanu",fullName:"Marian Găiceanu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/169608/images/system/169608.png",biography:"Prof. Dr. Marian Gaiceanu graduated from the Naval and Electrical Engineering Faculty, Dunarea de Jos University of Galati, Romania, in 1997. He received a Ph.D. (Magna Cum Laude) in Electrical Engineering in 2002. Since 2017, Dr. Gaiceanu has been a Ph.D. supervisor for students in Electrical Engineering. He has been employed at Dunarea de Jos University of Galati since 1996, where he is currently a professor. Dr. Gaiceanu is a member of the National Council for Attesting Titles, Diplomas and Certificates, an expert of the Executive Agency for Higher Education, Research Funding, and a member of the Senate of the Dunarea de Jos University of Galati. He has been the head of the Integrated Energy Conversion Systems and Advanced Control of Complex Processes Research Center, Romania, since 2016. He has conducted several projects in power converter systems for electrical drives, power quality, PEM and SOFC fuel cell power converters for utilities, electric vehicles, and marine applications with the Department of Regulation and Control, SIEI S.pA. (2002–2004) and the Polytechnic University of Turin, Italy (2002–2004, 2006–2007). He is a member of the Institute of Electrical and Electronics Engineers (IEEE) and cofounder-member of the IEEE Power Electronics Romanian Chapter. He is a guest editor at Energies and an academic book editor for IntechOpen. He is also a member of the editorial boards of the Journal of Electrical Engineering, Electronics, Control and Computer Science and Sustainability. Dr. Gaiceanu has been General Chairman of the IEEE International Symposium on Electrical and Electronics Engineering in the last six editions.",institutionString:'"Dunarea de Jos" University of Galati',institution:{name:'"Dunarea de Jos" University of Galati',country:{name:"Romania"}}},{id:"4519",title:"Prof.",name:"Jaydip",middleName:null,surname:"Sen",slug:"jaydip-sen",fullName:"Jaydip Sen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/4519/images/system/4519.jpeg",biography:"Jaydip Sen is associated with Praxis Business School, Kolkata, India, as a professor in the Department of Data Science. His research areas include security and privacy issues in computing and communication, intrusion detection systems, machine learning, deep learning, and artificial intelligence in the financial domain. He has more than 200 publications in reputed international journals, refereed conference proceedings, and 20 book chapters in books published by internationally renowned publishing houses, such as Springer, CRC press, IGI Global, etc. Currently, he is serving on the editorial board of the prestigious journal Frontiers in Communications and Networks and in the technical program committees of a number of high-ranked international conferences organized by the IEEE, USA, and the ACM, USA. He has been listed among the top 2% of scientists in the world for the last three consecutive years, 2019 to 2021 as per studies conducted by the Stanford University, USA.",institutionString:"Praxis Business School",institution:null},{id:"320071",title:"Dr.",name:"Sidra",middleName:null,surname:"Mehtab",slug:"sidra-mehtab",fullName:"Sidra Mehtab",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00002v6KHoQAM/Profile_Picture_1584512086360",biography:"Sidra Mehtab has completed her BS with honors in Physics from Calcutta University, India in 2018. She has done MS in Data Science and Analytics from Maulana Abul Kalam Azad University of Technology (MAKAUT), Kolkata, India in 2020. Her research areas include Econometrics, Time Series Analysis, Machine Learning, Deep Learning, Artificial Intelligence, and Computer and Network Security with a particular focus on Cyber Security Analytics. Ms. Mehtab has published seven papers in international conferences and one of her papers has been accepted for publication in a reputable international journal. She has won the best paper awards in two prestigious international conferences – BAICONF 2019, and ICADCML 2021, organized in the Indian Institute of Management, Bangalore, India in December 2019, and SOA University, Bhubaneswar, India in January 2021. Besides, Ms. Mehtab has also published two book chapters in two books. Seven of her book chapters will be published in a volume shortly in 2021 by Cambridge Scholars’ Press, UK. Currently, she is working as the joint editor of two edited volumes on Time Series Analysis and Forecasting to be published in the first half of 2021 by an international house. Currently, she is working as a Data Scientist with an MNC in Delhi, India.",institutionString:"NSHM College of Management and Technology",institution:null},{id:"226240",title:"Dr.",name:"Andri Irfan",middleName:null,surname:"Rifai",slug:"andri-irfan-rifai",fullName:"Andri Irfan Rifai",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/226240/images/7412_n.jpg",biography:"Andri IRFAN is a Senior Lecturer of Civil Engineering and Planning. He completed the PhD at the Universitas Indonesia & Universidade do Minho with Sandwich Program Scholarship from the Directorate General of Higher Education and LPDP scholarship. He has been teaching for more than 19 years and much active to applied his knowledge in the project construction in Indonesia. His research interest ranges from pavement management system to advanced data mining techniques for transportation engineering. He has published more than 50 papers in journals and 2 books.",institutionString:null,institution:{name:"Universitas Internasional Batam",country:{name:"Indonesia"}}},{id:"314576",title:"Dr.",name:"Ibai",middleName:null,surname:"Laña",slug:"ibai-lana",fullName:"Ibai Laña",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/314576/images/system/314576.jpg",biography:"Dr. Ibai Laña works at TECNALIA as a data analyst. He received his Ph.D. in Artificial Intelligence from the University of the Basque Country (UPV/EHU), Spain, in 2018. He is currently a senior researcher at TECNALIA. His research interests fall within the intersection of intelligent transportation systems, machine learning, traffic data analysis, and data science. He has dealt with urban traffic forecasting problems, applying machine learning models and evolutionary algorithms. He has experience in origin-destination matrix estimation or point of interest and trajectory detection. Working with large volumes of data has given him a good command of big data processing tools and NoSQL databases. He has also been a visiting scholar at the Knowledge Engineering and Discovery Research Institute, Auckland University of Technology.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"314575",title:"Dr.",name:"Jesus",middleName:null,surname:"L. Lobo",slug:"jesus-l.-lobo",fullName:"Jesus L. Lobo",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/314575/images/system/314575.png",biography:"Dr. Jesús López is currently based in Bilbao (Spain) working at TECNALIA as Artificial Intelligence Research Scientist. In most cases, a project idea or a new research line needs to be investigated to see if it is good enough to take into production or to focus on it. That is exactly what he does, diving into Machine Learning algorithms and technologies to help TECNALIA to decide whether something is great in theory or will actually impact on the product or processes of its projects. So, he is expert at framing experiments, developing hypotheses, and proving whether they’re true or not, in order to investigate fundamental problems with a longer time horizon. He is also able to design and develop PoCs and system prototypes in simulation. He has participated in several national and internacional R&D projects.\n\nAs another relevant part of his everyday research work, he usually publishes his findings in reputed scientific refereed journals and international conferences, occasionally acting as reviewer and Programme Commitee member. Concretely, since 2018 he has published 9 JCR (8 Q1) journal papers, 9 conference papers (e.g. ECML PKDD 2021), and he has co-edited a book. He is also active in popular science writing data science stories for reputed blogs (KDNuggets, TowardsDataScience, Naukas). Besides, he has recently embarked on mentoring programmes as mentor, and has also worked as data science trainer.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"103779",title:"Prof.",name:"Yalcin",middleName:null,surname:"Isler",slug:"yalcin-isler",fullName:"Yalcin Isler",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRyQ8QAK/Profile_Picture_1628834958734",biography:"Yalcin Isler (1971 - Burdur / Turkey) received the B.Sc. degree in the Department of Electrical and Electronics Engineering from Anadolu University, Eskisehir, Turkey, in 1993, the M.Sc. degree from the Department of Electronics and Communication Engineering, Suleyman Demirel University, Isparta, Turkey, in 1996, the Ph.D. degree from the Department of Electrical and Electronics Engineering, Dokuz Eylul University, Izmir, Turkey, in 2009, and the Competence of Associate Professorship from the Turkish Interuniversity Council in 2019.\n\nHe was Lecturer at Burdur Vocational School in Suleyman Demirel University (1993-2000, Burdur / Turkey), Software Engineer (2000-2002, Izmir / Turkey), Research Assistant in Bulent Ecevit University (2002-2003, Zonguldak / Turkey), Research Assistant in Dokuz Eylul University (2003-2010, Izmir / Turkey), Assistant Professor at the Department of Electrical and Electronics Engineering in Bulent Ecevit University (2010-2012, Zonguldak / Turkey), Assistant Professor at the Department of Biomedical Engineering in Izmir Katip Celebi University (2012-2019, Izmir / Turkey). He is an Associate Professor at the Department of Biomedical Engineering at Izmir Katip Celebi University, Izmir / Turkey, since 2019. In addition to academics, he has also founded Islerya Medical and Information Technologies Company, Izmir / Turkey, since 2017.\n\nHis main research interests cover biomedical signal processing, pattern recognition, medical device design, programming, and embedded systems. He has many scientific papers and participated in several projects in these study fields. He was an IEEE Student Member (2009-2011) and IEEE Member (2011-2014) and has been IEEE Senior Member since 2014.",institutionString:null,institution:{name:"Izmir Kâtip Çelebi University",country:{name:"Turkey"}}},{id:"339677",title:"Dr.",name:"Mrinmoy",middleName:null,surname:"Roy",slug:"mrinmoy-roy",fullName:"Mrinmoy Roy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/339677/images/16768_n.jpg",biography:"An accomplished Sales & Marketing professional with 12 years of cross-functional experience in well-known organisations such as CIPLA, LUPIN, GLENMARK, ASTRAZENECA across different segment of Sales & Marketing, International Business, Institutional Business, Product Management, Strategic Marketing of HIV, Oncology, Derma, Respiratory, Anti-Diabetic, Nutraceutical & Stomatological Product Portfolio and Generic as well as Chronic Critical Care Portfolio. A First Class MBA in International Business & Strategic Marketing, B.Pharm, D.Pharm, Google Certified Digital Marketing Professional. Qualified PhD Candidate in Operations and Management with special focus on Artificial Intelligence and Machine Learning adoption, analysis and use in Healthcare, Hospital & Pharma Domain. Seasoned with diverse therapy area of Pharmaceutical Sales & Marketing ranging from generating revenue through generating prescriptions, launching new products, and making them big brands with continuous strategy execution at the Physician and Patients level. Moved from Sales to Marketing and Business Development for 3.5 years in South East Asian Market operating from Manila, Philippines. Came back to India and handled and developed Brands such as Gluconorm, Lupisulin, Supracal, Absolut Woman, Hemozink, Fabiflu (For COVID 19), and many more. In my previous assignment I used to develop and execute strategies on Sales & Marketing, Commercialization & Business Development for Institution and Corporate Hospital Business portfolio of Oncology Therapy Area for AstraZeneca Pharma India Ltd. Being a Research Scholar and Student of ‘Operations Research & Management: Artificial Intelligence’ I published several pioneer research papers and book chapters on the same in Internationally reputed journals and Books indexed in Scopus, Springer and Ei Compendex, Google Scholar etc. Currently, I am launching PGDM Pharmaceutical Management Program in IIHMR Bangalore and spearheading the course curriculum and structure of the same. I am interested in Collaboration for Healthcare Innovation, Pharma AI Innovation, Future trend in Marketing and Management with incubation on Healthcare, Healthcare IT startups, AI-ML Modelling and Healthcare Algorithm based training module development. I am also an affiliated member of the Institute of Management Consultant of India, looking forward to Healthcare, Healthcare IT and Innovation, Pharma and Hospital Management Consulting works.",institutionString:null,institution:{name:"Lovely Professional University",country:{name:"India"}}},{id:"310576",title:"Prof.",name:"Erick Giovani",middleName:null,surname:"Sperandio Nascimento",slug:"erick-giovani-sperandio-nascimento",fullName:"Erick Giovani Sperandio Nascimento",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0033Y00002pDKxDQAW/ProfilePicture%202022-06-20%2019%3A57%3A24.788",biography:"Prof. Erick Sperandio is the Lead Researcher and professor of Artificial Intelligence (AI) at SENAI CIMATEC, Bahia, Brazil, also working with Computational Modeling (CM) and HPC. He holds a PhD in Environmental Engineering in the area of Atmospheric Computational Modeling, a Master in Informatics in the field of Computational Intelligence and Graduated in Computer Science from UFES. He currently coordinates, leads and participates in R&D projects in the areas of AI, computational modeling and supercomputing applied to different areas such as Oil and Gas, Health, Advanced Manufacturing, Renewable Energies and Atmospheric Sciences, advising undergraduate, master's and doctoral students. He is the Lead Researcher at SENAI CIMATEC's Reference Center on Artificial Intelligence. In addition, he is a Certified Instructor and University Ambassador of the NVIDIA Deep Learning Institute (DLI) in the areas of Deep Learning, Computer Vision, Natural Language Processing and Recommender Systems, and Principal Investigator of the NVIDIA/CIMATEC AI Joint Lab, the first in Latin America within the NVIDIA AI Technology Center (NVAITC) worldwide program. He also works as a researcher at the Supercomputing Center for Industrial Innovation (CS2i) and at the SENAI Institute of Innovation for Automation (ISI Automação), both from SENAI CIMATEC. He is a member and vice-coordinator of the Basic Board of Scientific-Technological Advice and Evaluation, in the area of Innovation, of the Foundation for Research Support of the State of Bahia (FAPESB). He serves as Technology Transfer Coordinator and one of the Principal Investigators at the National Applied Research Center in Artificial Intelligence (CPA-IA) of SENAI CIMATEC, focusing on Industry, being one of the six CPA-IA in Brazil approved by MCTI / FAPESP / CGI.br. He also participates as one of the representatives of Brazil in the BRICS Innovation Collaboration Working Group on HPC, ICT and AI. He is the coordinator of the Work Group of the Axis 5 - Workforce and Training - of the Brazilian Strategy for Artificial Intelligence (EBIA), and member of the MCTI/EMBRAPII AI Innovation Network Training Committee. He is the coordinator, by SENAI CIMATEC, of the Artificial Intelligence Reference Network of the State of Bahia (REDE BAH.IA). He leads the working group of experts representing Brazil in the Global Partnership on Artificial Intelligence (GPAI), on the theme \"AI and the Pandemic Response\".",institutionString:"Manufacturing and Technology Integrated Campus – SENAI CIMATEC",institution:null},{id:"1063",title:"Prof.",name:"Constantin",middleName:null,surname:"Volosencu",slug:"constantin-volosencu",fullName:"Constantin Volosencu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/1063/images/system/1063.png",biography:"Prof. Dr. Constantin Voloşencu graduated as an engineer from\nPolitehnica University of Timișoara, Romania, where he also\nobtained a doctorate degree. He is currently a full professor in\nthe Department of Automation and Applied Informatics at the\nsame university. Dr. Voloşencu is the author of ten books, seven\nbook chapters, and more than 160 papers published in journals\nand conference proceedings. He has also edited twelve books and\nhas twenty-seven patents to his name. He is a manager of research grants, editor in\nchief and member of international journal editorial boards, a former plenary speaker, a member of scientific committees, and chair at international conferences. His\nresearch is in the fields of control systems, control of electric drives, fuzzy control\nsystems, neural network applications, fault detection and diagnosis, sensor network\napplications, monitoring of distributed parameter systems, and power ultrasound\napplications. He has developed automation equipment for machine tools, spooling\nmachines, high-power ultrasound processes, and more.",institutionString:"Polytechnic University of Timişoara",institution:{name:"Polytechnic University of Timişoara",country:{name:"Romania"}}},{id:"221364",title:"Dr.",name:"Eneko",middleName:null,surname:"Osaba",slug:"eneko-osaba",fullName:"Eneko Osaba",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/221364/images/system/221364.jpg",biography:"Dr. Eneko Osaba works at TECNALIA as a senior researcher. He obtained his Ph.D. in Artificial Intelligence in 2015. He has participated in more than twenty-five local and European research projects, and in the publication of more than 130 papers. He has performed several stays at universities in the United Kingdom, Italy, and Malta. Dr. Osaba has served as a program committee member in more than forty international conferences and participated in organizing activities in more than ten international conferences. He is a member of the editorial board of the International Journal of Artificial Intelligence, Data in Brief, and Journal of Advanced Transportation. He is also a guest editor for the Journal of Computational Science, Neurocomputing, Swarm, and Evolutionary Computation and IEEE ITS Magazine.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"275829",title:"Dr.",name:"Esther",middleName:null,surname:"Villar-Rodriguez",slug:"esther-villar-rodriguez",fullName:"Esther Villar-Rodriguez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/275829/images/system/275829.jpg",biography:"Dr. Esther Villar obtained a Ph.D. in Information and Communication Technologies from the University of Alcalá, Spain, in 2015. She obtained a degree in Computer Science from the University of Deusto, Spain, in 2010, and an MSc in Computer Languages and Systems from the National University of Distance Education, Spain, in 2012. Her areas of interest and knowledge include natural language processing (NLP), detection of impersonation in social networks, semantic web, and machine learning. Dr. Esther Villar made several contributions at conferences and publishing in various journals in those fields. Currently, she is working within the OPTIMA (Optimization Modeling & Analytics) business of TECNALIA’s ICT Division as a data scientist in projects related to the prediction and optimization of management and industrial processes (resource planning, energy efficiency, etc).",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"49813",title:"Dr.",name:"Javier",middleName:null,surname:"Del Ser",slug:"javier-del-ser",fullName:"Javier Del Ser",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49813/images/system/49813.png",biography:"Prof. Dr. Javier Del Ser received his first PhD in Telecommunication Engineering (Cum Laude) from the University of Navarra, Spain, in 2006, and a second PhD in Computational Intelligence (Summa Cum Laude) from the University of Alcala, Spain, in 2013. He is currently a principal researcher in data analytics and optimisation at TECNALIA (Spain), a visiting fellow at the Basque Center for Applied Mathematics (BCAM) and a part-time lecturer at the University of the Basque Country (UPV/EHU). His research interests gravitate on the use of descriptive, prescriptive and predictive algorithms for data mining and optimization in a diverse range of application fields such as Energy, Transport, Telecommunications, Health and Industry, among others. In these fields he has published more than 240 articles, co-supervised 8 Ph.D. theses, edited 6 books, coauthored 7 patents and participated/led more than 40 research projects. He is a Senior Member of the IEEE, and a recipient of the Biscay Talent prize for his academic career.",institutionString:"Tecnalia Research & Innovation",institution:null},{id:"278948",title:"Dr.",name:"Carlos Pedro",middleName:null,surname:"Gonçalves",slug:"carlos-pedro-goncalves",fullName:"Carlos Pedro Gonçalves",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRcmyQAC/Profile_Picture_1564224512145",biography:'Carlos Pedro Gonçalves (PhD) is an Associate Professor at Lusophone University of Humanities and Technologies and a researcher on Complexity Sciences, Quantum Technologies, Artificial Intelligence, Strategic Studies, Studies in Intelligence and Security, FinTech and Financial Risk Modeling. He is also a progammer with programming experience in:\n\nA) Quantum Computing using Qiskit Python module and IBM Quantum Experience Platform, with software developed on the simulation of Quantum Artificial Neural Networks and Quantum Cybersecurity;\n\nB) Artificial Intelligence and Machine learning programming in Python;\n\nC) Artificial Intelligence, Multiagent Systems Modeling and System Dynamics Modeling in Netlogo, with models developed in the areas of Chaos Theory, Econophysics, Artificial Intelligence, Classical and Quantum Complex Systems Science, with the Econophysics models having been cited worldwide and incorporated in PhD programs by different Universities.\n\nReceived an Arctic Code Vault Contributor status by GitHub, due to having developed open source software preserved in the \\"Arctic Code Vault\\" for future generations (https://archiveprogram.github.com/arctic-vault/), with the Strategy Analyzer A.I. module for decision making support (based on his PhD thesis, used in his Classes on Decision Making and in Strategic Intelligence Consulting Activities) and QNeural Python Quantum Neural Network simulator also preserved in the \\"Arctic Code Vault\\", for access to these software modules see: https://github.com/cpgoncalves. He is also a peer reviewer with outsanding review status from Elsevier journals, including Physica A, Neurocomputing and Engineering Applications of Artificial Intelligence. Science CV available at: https://www.cienciavitae.pt//pt/8E1C-A8B3-78C5 and ORCID: https://orcid.org/0000-0002-0298-3974',institutionString:"University of Lisbon",institution:{name:"Universidade Lusófona",country:{name:"Portugal"}}},{id:"241400",title:"Prof.",name:"Mohammed",middleName:null,surname:"Bsiss",slug:"mohammed-bsiss",fullName:"Mohammed Bsiss",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/241400/images/8062_n.jpg",biography:null,institutionString:null,institution:null},{id:"276128",title:"Dr.",name:"Hira",middleName:null,surname:"Fatima",slug:"hira-fatima",fullName:"Hira Fatima",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/276128/images/14420_n.jpg",biography:"Dr. Hira Fatima\nAssistant Professor\nDepartment of Mathematics\nInstitute of Applied Science\nMangalayatan University, Aligarh\nMobile: no : 8532041179\nhirafatima2014@gmal.com\n\nDr. Hira Fatima has received his Ph.D. degree in pure Mathematics from Aligarh Muslim University, Aligarh India. Currently working as an Assistant Professor in the Department of Mathematics, Institute of Applied Science, Mangalayatan University, Aligarh. She taught so many courses of Mathematics of UG and PG level. Her research Area of Expertise is Functional Analysis & Sequence Spaces. She has been working on Ideal Convergence of double sequence. She has published 17 research papers in National and International Journals including Cogent Mathematics, Filomat, Journal of Intelligent and Fuzzy Systems, Advances in Difference Equations, Journal of Mathematical Analysis, Journal of Mathematical & Computer Science etc. She has also reviewed few research papers for the and international journals. She is a member of Indian Mathematical Society.",institutionString:null,institution:null},{id:"414880",title:"Dr.",name:"Maryam",middleName:null,surname:"Vatankhah",slug:"maryam-vatankhah",fullName:"Maryam Vatankhah",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Borough of Manhattan Community College",country:{name:"United States of America"}}},{id:"414879",title:"Prof.",name:"Mohammad-Reza",middleName:null,surname:"Akbarzadeh-Totonchi",slug:"mohammad-reza-akbarzadeh-totonchi",fullName:"Mohammad-Reza Akbarzadeh-Totonchi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Ferdowsi University of Mashhad",country:{name:"Iran"}}},{id:"414878",title:"Prof.",name:"Reza",middleName:null,surname:"Fazel-Rezai",slug:"reza-fazel-rezai",fullName:"Reza Fazel-Rezai",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"American Public University System",country:{name:"United States of America"}}},{id:"302698",title:"Dr.",name:"Yao",middleName:null,surname:"Shan",slug:"yao-shan",fullName:"Yao Shan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Dalian University of Technology",country:{name:"China"}}},{id:"125911",title:"Prof.",name:"Jia-Ching",middleName:null,surname:"Wang",slug:"jia-ching-wang",fullName:"Jia-Ching Wang",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"National Central University",country:{name:"Taiwan"}}},{id:"357085",title:"Mr.",name:"P. 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He obtained his Master’s degree in the Department of Information and Communications from Gwangju Institute of Science and Technology (GIST) in 2003. In 2010, he received his Ph.D. degree in the School of Information and Mechatronics from GIST. In the meantime, he was an executed team leader at Culture Technology Institute, GIST, 2010-2012. In 2011, he worked at Lancaster University, the UK as a visiting scholar. In September 2012, he joined Daegu University, where he is currently an associate professor in the School of ICT Conver, Daegu University. Also, he served as the Board of Directors of KSIIS since 2019, and HCI Korea since 2016. From 2017~2019, he worked as a center director of the Mixed Reality Convergence Research Center at Daegu University. From 2015-2017, He worked as a director in the Enterprise Supporting Office of LINC Project Group, Daegu University. His research interests include Activity Fusion & Reasoning, Machine Learning, Context-aware Middleware, Human-Computer Interaction, etc.",institutionString:null,institution:{name:"Daegu Gyeongbuk Institute of Science and Technology",country:{name:"Korea, South"}}},{id:"262719",title:"Dr.",name:"Esma",middleName:null,surname:"Ergüner Özkoç",slug:"esma-erguner-ozkoc",fullName:"Esma Ergüner Özkoç",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Başkent University",country:{name:"Turkey"}}},{id:"346530",title:"Dr.",name:"Ibrahim",middleName:null,surname:"Kaya",slug:"ibrahim-kaya",fullName:"Ibrahim Kaya",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Izmir Kâtip Çelebi University",country:{name:"Turkey"}}},{id:"419199",title:"Dr.",name:"Qun",middleName:null,surname:"Yang",slug:"qun-yang",fullName:"Qun Yang",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Auckland",country:{name:"New Zealand"}}}]}},subseries:{item:{id:"22",type:"subseries",title:"Applied Intelligence",keywords:"Machine Learning, Intelligence Algorithms, Data Science, Artificial Intelligence, Applications on Applied Intelligence",scope:"This field is the key in the current industrial revolution (Industry 4.0), where the new models and developments are based on the knowledge generation on applied intelligence. 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His research lines are biometrics, biomedical signals and images, data mining, classification system, signal and image processing, machine learning, and environmental intelligence. He has researched in 52 international and Spanish research projects, some of them as head researcher. He is co-author of 4 books, co-editor of 27 proceedings books, guest editor for 8 JCR-ISI international journals, and up to 24 book chapters. He has over 450 papers published in international journals and conferences (81 of them indexed on JCR – ISI - Web of Science). He has published seven patents in the Spanish Patent and Trademark Office. He has been a supervisor on 8 Ph.D. theses (11 more are under supervision), and 130 master theses. He is the founder of The IEEE IWOBI conference series and the president of its Steering Committee, as well as the founder of both the InnoEducaTIC and APPIS conference series. 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He was vice dean from 2004 to 2010 in the Higher Technical School of Telecommunication Engineers at ULPGC and the vice dean of Graduate and Postgraduate Studies from March 2013 to November 2017. 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