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Both the numbers of years we live and the quality of health has increased more in the last 150 years than in any prior time in human history. It is interesting that QALYs were invented at the same time the variables that go into defining QALYs are changing so rapidly. The U.S. National Council on Disability (NCD) has found sufficient evidence that QALYs are discriminatory by design, and suggested Congress should pass legislation prohibiting the use of QALYs by Medicaid and Medicare [1]. What constitutes a disability and how much should it decrease QALYs? There have been deaf families that argue deafness is not a disability, it heightens other senses, and have chosen not to have cochlear implants. What QALY hit do paraplegics receive compared to quadriplegics? The very nature of QALYs cause users to assign some agreed upon weights to life abilities.
The average human lifespan has increased 80% over the last 120 years, with a clear increase in longevity starting at the end of the 19th century (around 1890). Those living in the United Kingdom, increased average lifespan from 45.2 to 81 years from 1890 to 2015. The United States had a similar increase, doing slightly less well recently with an average lifespan of 79 in 2015. The global average lifespan started from a lower level with its significant increase delayed a decade (1900) but has paralleled the gains each year achieving even more impressive results, starting at 32 years in 1900 and rising to 71.7 years in 2015 [2] (Figure 1). Starting in the 20th Century infant mortality plummeted from 10% to under 1% currently, which significantly contributed to the average lifespan. However, if you look at mortality rates at later ages it is apparent that lifespan has increased after keeping infants alive [3]. There is significant scientific data now that, across the animal kingdom, caloric restriction extends life [4, 5, 6, 7, 8, 9] which provided hope we could continue the trend increasing human longevity. In mice a 60% reduction in calories has been shown to increase lifespan by about a third, however in humans and primates it appears we may only be able to extend our lives 1–5 years [10, 11] though research is ongoing [12].
Life Expectancy and Expenditure on Healthcare increase over time. Source: Our World in Data.
It has been estimated that while clinical care accounts for 15% of the quality of one’s health, clinical care data only represents 0.1% of the data (0.4 terabytes) applicable to health outcomes over their lifetime (1,106 terabytes) [13]. Most of the data that affects one’s health (1,100 terabytes) concerns one’s social determinants of health and health behaviors which account for 40% and 20% of one’s quality of health respectively. The last 25% of one’s health is determined by “Nonmodifiable factors” such as genetics, but this data (6 terabytes) is still very actionable in that different actions (e.g. pharmaceuticals, diet, lifestyle interventions) can be taken based on one’s genetics. While it is likely most easy to modify healthcare’s actions in clinical care, because it only represents 15% of our health outcomes, in order to maximize QALYs we must invest in analyzing and modifying the other data realms that affect our lifetime biomedical health (social determinants of health, health behaviors, and nonmodifiable factors).
Medical spending has increased by an order of magnitude in the last 200 year as a proportion of GDP. The share of GDP used on healthcare in 1800, 1850, 1900, 1950, 200o was 2%, 2.1%, 2.5%, 4.5%, 13.5% respectively (Figure 1) [14]. There is a clear and historically long trend of healthcare accounting for larger percentages of GDP in the developing world. Despite concern that this increased expenditure is just going to fatten the profits of big pharma, the reality is more nuanced with significantly more people and services being funded. Concomitantly and unsurprisingly, in the U.S. rapid growth is projected in both health and STEM occupations while office support, food service, and manufacturing production jobs will decline [1]. In order to maintain or lower the cost of healthcare, country’s must either lower costs per treatment (increased efficiency) or reduce treatment provided (decreased expenditure). While everyone would like the former solution of getting the same treatment for cheaper, the continual rise in healthcare expenditures despite plateauing lifespan suggests cuts will be needed. There are large economic differences in healthcare expenditures between countries which do not translate to better care. Common examples are the United States spending 10-fold more per citizen than Cuba despite similar life expectancies. The counties of the E.U. also spend less than the United States while having the same or better life spans. The successes and failures of using QALYs to reduce healthcare costs will be discussed. Most of the QALY issues discussed apply globally. However, this chapter will focus on data and issues in the United States, which is unusual among industrialized countries because it does not have a single payer system, and therefore has uniquely heightened QALY misallocations.
In 1976 Zeckhauser and Shepard first used the term Quality-Adjusted Life Years (QALYs) to describe measurements of health outcomes which were defined by both duration and quality of life measurements [15]. Pliskin detailed the three assumptions QALYs required to act as valid metrics to assign health resources [16], namely:
Independence between health status and life years
A constant proportional trade-off
Risk neutrality of life years
While these foundational assumptions of QALYs have been questioned [17], they have been globally accepted and used by most countries for making economic decisions [18, 19, 20, 21].
Two decades after the description of a QALY, the Disability-Adjusted Life Years (DALYs) were developed in the 1990s measuring both duration as well as quality. DALYs by definition measure disease burden but are also often used like QALYs to maximize cost-effectiveness. QALYs have a health-related quality of life weighting (Q) that ranges from 0 to 1, with 1 representing a year of perfect health and 0 representing death. A Q measure of 0.5 has been expressed as bed ridden, and it should be noted that a state considered “worse” than death can have a negative Q rating. The quality of life each year can be added up to calculate one’s quality-adjusted life expectancy (QALE). On the other hand DALYs are measured from 0 to 1 where 0 represents no disability. Therefore in QALYs the higher the weighting the better, but in DALYs the lower the weighting the better. Usually expert valuations are assigned to a universal set of weightings for DALYs, whereas QALYs use preference-based health-related measures gathered from groups of patients or the general population [22]. DALYs have an age-weighting function, and can therefore preferentially favor spending money on the young versus the old compared to QALYs.
QALYs lived in one year = 1*Q (where Q ≤ 1)
Qt = Health related quality of life weighting at year t.
QALE = quality-adjusted life expectancy at a given age.
RLE = Residual Life Expectancy at given age.
t = individual years within residual life expectancy range.
As QALYS are used to determine the allotment of financial resources, the age of the citizens receiving these resources can be a significant issue. The most common causes of death in the U.S. (stroke, cancer, Chronic Lower Respiratory Diseases (CLRD), Alzheimers, heart disease, and diabetes) debilitate patients for a broad duration, ranging from immediate death to 20 years (Table 1, Figure 2). Death can occur suddenly with almost no recourse for intervention or financial expenditure by society aimed to improve life, such as in an unforeseen and lethal suicide or stroke. However, disease care is becoming more often a case of extended managed care, such as with diabetes.
Disease | Total Deaths (million, U.S. 2017) | Deaths/100,000 (U.S. 2017) | Deaths/100,000 (U.S. 2007) | Change 2007–2017 (% change) | Average duration of disease |
---|---|---|---|---|---|
Heart disease | 647 | 165 | 190.9 | −13.6 | 7.3 yrs |
Cancer | 599 | 152.5 | 178.4 | −14.5 | 2 yrs |
Chronic lower respiratory diseases (CLRD) | 160 | 40.9 | 40.8 | 0 | 4 yrs |
Stroke | 146 | 37.6 | 43.5 | −13.6 | 1 yr |
Alzheimer disease | 121 | 31 | 22.7 | 36.6 | 6 yrs |
Diabetes | 84 | 21.5 | 22.5 | −4.4 | 30 yrs |
Influenza and pneumonia | 56 | 14 | 15.7 | −10.8 | 1.5 weeks |
Kidney disease | 51 | 13 | 15.7 | −17.2 | 7 yrs |
Suicide | 47 | 14 | 11.3 | 23.9 | 1 day |
Duration of Disease vs. Population Effect.
Data was retrieved from the National Vital Statistics Reports Final Death Reports. The color coding represents better values in green (low deaths, low disease duration, and decreased deaths over time) adn worse values in red.
Length of Public Health Issues vs. Population Effect.
The philosophical framework termed “fair innings” posits that each human has an equal right to experience each phase (age) of life. Therefore if the same intervention could extend for one year the life of a 60-year-old or a 26-year-old, then the younger patient should preferentially get the intervention so they have their “fair-inning” at living the age of 27. Human lifespan has roughly doubled in the last century, from roughly 40 to 80 years of life in the developed world. Does a child that is born into the world that now lives 10% longer than their parents have the scaled protection to get to the world’s future average lifespan (10% older than their parents), or do fair innings apply as a static set of years based on the oldest generations having care rationed? If nations had been rationing care based on the “fair innings” philosophy they would have possibly undervalued young years of life if they were not taking into account the projected increase in lifespan for younger generations. Recently the lifespan in the United States decreased for the first time in decades due to a combination of macro health issues (obesity, opiod overdose, and suicide epidemics). While the current U.S. healthcare system does not ration care based on fair innings principles, if it had done so and taken into account the longstanding historical increases in lifespan younger generations would have received more resources than deemed fair in hindsight since their projected lifespan has dropped from historical trends. One of the most important aspects for implementing allotment of healthcare resources based on QALYs is for the electorate to have supreme confidence in its fairness. The use of fair innings is very transparent in taking from one group (older) to give to another group (younger), and any projection based on moving average lifespans could increase the publics distrust in QALY use for policy decisions.
In 1986 Albert Jonsen coined the term “Rule of Rescue” which described the medical community’s unwillingness to allow patients to die, even when a high cost to save them made the QALY calculation suggest the resources would be better used elsewhere [23]. Jonsen described examples of sitting on various committees to decide the value of interventions (artificial heart, cardiac transplantation, amniocentesis, liver transplant, autologous bone marrow transplantation), and a recurring theme emerged in which the debate would go down a consistent path detailing the high cost per QALY only to end abruptly with the group deciding the lives must be saved. These expensive transplant procedures are still covered in the United States despite continued poor QALY analysis. As genetic knowledge and biomedical technologies have continued to advance, the list of expensive procedures that deliver increased QALYs to patients, however the absolute cost and % of GDP spent on healthcare has also continued to rise. The incremental cost effectiveness ratio per QALY needs to be calculated for these high ticket items. For example, the recent chimeric antigen receptor T cell therapy (CAR-T therapy) [24] appears cost effective 95% of the time, assuming a willingness to pay $100,000 USD for each QALY gained, despite costing roughly half a million dollars USD in the United States (depending on the type of B-cell malignancy) [25]. The incremental cost-effectiveness ratio (ICER) for CAR-T was found to be somewhere between roughly $64,000/QALY and $175,000 depending on the study and assumptions for average 5-year progression-free survival (PFS) [25, 26, 27].
The Rule of Rescues inability to allow an overly expensive life to end has resoundingly caused a decrease in quality of life years. Attempts have been made over the last half century in the United States to limit excessive expenditures for care during the last two years of life, but almost all have failed. Some have argued the rule of rescue is defensible even from a utilitarian point of view in that the citizenry will have increased “well-being” because they desire living in a community that values life, and while that trend is likely true it cannot defend the rule of rescue without bounds [28]. Most see the rule of rescue as contradicting the utilitarian nature of QALY optimization for healthcare expenditures.
The Affordable Care Act (ACA, also known as Obamacare) was the greatest leap towards universal coverage in the United States in the last 50 years (since Medicaid was signed into law in 1965), but is not close to the single payer systems that Europe has long implemented. The ACA initially proposed paying physicians if they provided voluntary counseling to Medicare patients about end-of-life care options, advance directives, or living wills. During the 2009 presidential debate Sarah Palin famously termed these clauses “death panels” describing a future where doctors decided whose parents would die. These aspects of the bill were removed before final passage as result of public pressure.
The standard gamble is a more patient specific measure of if a medical intervention should be done. Figure 3 shows a simple standard gamble in which a health intervention could result in either a better or worse outcomes than no intervention (e.g. an organ transplant). The probability p of the best outcome (healthy), is changed until the patient has no preference over whether to get the medical intervention or not, at which point their personalized standard gamble has been calculated [22]. There are other standard gamble scenarios/diagrams when, for example, no outcome results in death, or any intervention outcome is higher than lack of intervention.
Standard Gamble.
Should a pregnant woman in need of care have QALYs counted for herself and her baby, just herself, just her baby, and how does the age of the fetus change that calculus? If one adheres to the “fair innings” paradigm (see above), then the early years of a newborn are more valuable than the mothers later years. It seems clear that if a female near term needed resources her QALY measurement should, at a minimum, be the greater childs QALYs if fair innings were being taken into account. QALYs are often not scaled by age (no fair innings implementation) and the pregnant female would have resources assigned worth double a single person (with equal weight for her and her child). In reality there are often not even the attempted use of QALYs in such situations in the United States, because lethal pregnancy issues are handled like other Emergency Department critical patients following the rule of rescue (see above) in that any resources are used to save the lives at that moment. Costs of infertility treatment share many of these same QALY accounting issues, and have other societal/ethical issues in addition. For example, early this century the UK ‘s National Institute for Clinical Excellence (NICE) covered infertility costs but explicitly excluded “social infertility” which includes a woman being single or homosexual. Under that paradigm a woman 40 years of age that has fertility issues could qualify for in vitro fertilization (IVF) over a woman half her age that happens to be single and/or a lesbian [29]. Similarly to how the rule of rescue trumps all other QALY calculations, societal norms can have a trumping effect of completely removing groups from medical coverage. A common delimiter for excluding a group from medical coverage is if there is a nonmedical lifestyle action/intervention to effect the same increase in QALYs, such as finding a male spouse in the above example. To the authors’ knowledge no country has seriously addressed this issue in any way other than looking at them on a case by case basis by a panel (e.g. by health experts, philosophers, politicians).
Women live longer than men across the globe (~8% or 6 years). Roughly $100,000 USD more is spent on women’s health than men during their life ($375,000 $275,000). Since healthcare later in life is more expensive this translates to women costing society more as they live longer during an expensive healthcare phase. Roughly half (45%) of women’s increased healthcare costs come just from this longer lifespan. However individual situations could have calculations suggesting women get more than parity in resources. For example, if 50-year-old male and a 51-year-old female needed the same resource (such as an organ transplant) the longer female lifespan could suggest even a slightly older woman should take precedence over her junior male counterpart.
The transplant of organs could theoretically have extremely positive QALY returns per dollar spent, depending on the age. There are a plethora of ethical issues that arise from organ donations however, such as how important is the patient’s age, their relation to the organ donor, the duration of organ viability after transplantation, or the degree to which their personal actions resulted in their need for an organ transplant.
If a young child in need of an organ could live a full life time with one transplant the QALY calculations would likely result in societies funding these transplants without any second guessing. Indeed curably treating young patients with a lethal disease is the best scenario to maximize QALYs gained, if comparing similarly priced interventions. However, organ transplants often do not alleviate a patient’s disease for a normal lifespan. For example, cystic fibrosis (CF) patients most often die from lung failure due to thick mucus and biofilm accumulation leading to necrosis of the tissue. Lung transplants are done for CF patients but transplants usually only perform sufficiently for 5 years. CF patients can now live over 40 years, double the 20 year lifespan they had half a century ago. Therefore, contrary to other QALY based interventions, transplants are not recommended for the younger CF patients.
While most donated organs come from donors after they have died, there are also living organ donations. Directed living organ donation, the most common type as opposed to non-directed organ donation, allows the donor to choose the recipient (often a family member) [30]. Even the most rigorous ordering of donor recipients using rankings to maximize QALYs can suddenly be shortcut by directed living organ donors. This is an example where there is a limited supply (of organs) and the calculations to maximize QALYs changes because a family member is willing to increase that limited supply but only if used in the manner they want. Therefore there are times when a healthcare system can increase QALYs at the sacrifice of absolute ethical parity of all patients based on their need.
Smokers receiving lung transplants is another case example highlighting societies’ concern about funding healthcare solutions for ailments which has been self-inflicted. More than a third of lung transplants in the U.S. are for former smokers (40%), but they often only qualify once they have proven they have quit smoking. This achieves two outcomes. Most quantifiably it increases QALYs in that a lung transplant given to someone who will never smoke again, will on average produce more QALYs than if the lung transplant were given to someone that immediately starts smoking multiple packs a day after surgery. It also addresses the moral issue, allowing the donor and society to feel like the gift of the organ is being valued by the recipient. However one study showed after smokers receive lung transplants 11% admitted they resumed smoking, with another 6% showing high levels of urinary cotinine (a metabolite of nicotine). These values are similar to heart and renal transplant recipients, who reported smoking after transplantation at a frequency of 21% and 25% respectively [31].
There are many health issues for which the individual is primarily responsible. Smoking and alcoholism may be the best examples. A recent study showed that cessation of smoking alone could save up to 12 years of life [32]. Should the population that lives a healthier lifestyle pay for the less healthy lifestyle chosen by other individuals? Even cases that seem extremely clear, such as smoking, are often more complicated. For example, those living in Beijing, China have the exposure equivalent to smoking 25 cigarettes per day, just from breathing in the high particulate air [33, 34]. It seems unfair to not cover the respiratory issues of a child born in Bejing, just because those same respiratory issues are self-induced by a heavy smoker in the countryside.
For a decade scientific papers appeared to show low levels of alcohol could be beneficial, with people pointing to the resveratrol in wine as an epigenetic antiaging molecule, or the blue zones of the world that consumed red wine such as Italy. In reality their high fish, high vegetable, and low calorie diet are greater life prolonging life styles. It also turns out in many of these studies the alcohol “abstainer” groups had prior alcoholics included in them, who had previously changed their lifestyle to never consume alcohol. While the abstainer group had slightly poorer health than the one drink a day group, it is likely that could be due to prior damage the alcoholics had done to their body before becoming abstainers. Such scientific errors will cause resources to be misallocated if QALYs are used coarsely to allocate every dime of resource. Should alcoholics be required to quit drinking before receiving a liver transplant? Is one drink a day ok for them. One drink a day should be physically ok for the transplanted liver, but could cause the patient to slip and start drinking heavily again. Heavy alcohol consumption clearly causes cirrhosis of the liver, however contrary to the lay public’s view this is the second leading cause of cirrhosis (while hepatitis C is the leading cause) [35]. Not publicly funding healthcare for self-induced ailments clearly could save significant percentages of healthcare expenditures. However, it could lead to patients lying about their health habits and is difficult to implement fairly given the multimodal hazards for multiple diseases.
Diabetes and Alzheimer disease are two of the most serious medical conditions the developed world must grapple with. Both diseases are increasing rapidly in the population, while patients are able to live with the conditions for over a decade. Alzheimer’s will not be discussed as there are excellent reviews of the issues [36, 37, 38], but in short it poses a problem in that there is no treatment on the horizon. Diabetes (type II) on the other hand is extremely targetable, with reduced caloric consumption and exercise literally at the patients finger tips. However, both of these solutions have some socioeconomic interacting factors. Wealthier people can afford the time for leisure exercise, and can buy more expensive but healthier food that is less calorically dense (e.g. fresh vegetables). Some of these caveats are not as pernicious as they sound. While some fresh vegetables can be expensive and perishable, frozen vegetables, potatoes, and legumes are all healthy and cheap with a long shelf life. In addition, while difficult, anyone can choose to “just eat less” which actually has a negative cost. The true social cost to reduced calorie intervention is in building and supporting structures to increase the success rate obese individuals have in transitioning from an unhealthy to healthy lifestyle.
Are genetic predispositions a disability? Generally any inherited disorder is more likely to have healthcare solutions funded for it than self-imposed maladies. Historically these inherited disabilities have been very binary, e.g. an extreme life threatening autosomal recessively inherited disease in which a child had the poor misfortune, 25% chance, of getting both deleterious alleles from their mom and dad. However we are now getting genetic knowledge that a person is only predisposed to ailments, which often have environmental causes as well. For example obese grandparents can pass on epigenetic modifications to their grandchildren that makes them 4-fold more likely to be diabetic. Is that a self-induced ailment? The grandparents might have caused their metabolic disorder by overeating, but the grandchildren clearly started birth with a biological handicap.
Hemodialysis, the most common form of dialysis, performs the kidneys function by taking a patient’s blood through a filter outside of their body (cleaning it), and then returning it to their body. Dialysis is a one of the most common, expensive, and recurring treatments in developed countries, with diabetics greatly predisposed to need treatment [39]. Diabetics, by definition, cannot control their blood glucose levels and their kidneys are therefore working overtime to continually secrete excess sugar from the blood, often ending in organ failure. Early type II diabetics (<5 years of disease) do not cost society a lot in healthcare, with depression being the costliest comorbidity (64–82% increase). However, the later nonfatal complications have much larger increases in healthcare costs: end-stage renal disease with dialysis (201–599%), hemorrhagic/ischemic stroke (37–376%), and amputation of upper/lower-extremities (13–279%). Fatal complications had even larger cost increases with cardiovascular death being the most expensive (1,784–2,001%), but “other-cause deaths” being costly as well (1,285–1,584%) [40]. The rule of rescue makes these later expensive interventions covered, while spending that money on prevention earlier would save more QALYs/$.
When assigning QALYs gained by a medical intervention both the duration of extra time lived and the quality of that time need to be measured, with the former being a much easier/reproducible value to calculate. There are many extreme health scenarios (e.g. wars, population changes, climate change, paradigm shifts creating seemingly unlimited resources) that are useful examples to walk through when considering how QALYs should be measured and used to alot resources.
Warfare represents an extreme environment in which both the broad and mortal health need can bring clarity to how we perform our healthcare resource allocation decisions. During war the local healthcare capability can change quickly as resources are stressed both geographically and temporally. Medical triage during war is needed to use the limited medical personal and resources for those most likely to benefit from that care. In extreme examples this can include neglecting dying patients who could be saved during less strenuous times.
Medics are viewed as more important because they can in the immediate future save more lives. The future potential of one to increase QALYs of others is a thorny topic. How far in the future can you predict this and how certain do you need to be? The argument has been made that richer people that own companies could have more highly weighted QALYs because they employ others, raise the Gross Domestic Product (GDP), which causes a greater tax base to contribute more taxes towards the healthcare infrastructure therefore increasing the resources to improve QALYs. Such an argument clarifies a known tradeoff when measuring and using QALYs: there are times when a known method to increase QALYs is openly not desired or acted on because of the consensus that it would not be fair. Therefore, while QALYs are usually presented in a completely utilitarian view, their implementation openly breaks this at will when there is a consensus that the increased utility would come at the cost of equality for the program’s participants. This favoring of fairness over utility may be because the equality or lack thereof is apparent immediately at each decision point, whereas the utility gain is often deferred temporally (sometimes as long as decades into the future).
The value assigned to a new human life can change during an individual’s life or as a society evolves. Early in life people may not be ready to care for a child and choose to terminate pregnancies, saving their resources for the average 1–3 children they want to have later in their life. As nations become more wealthy their population chooses to have less children, investing more resources in the quality of each life. In the last two centuries human population has grown exponentially. If the total sum of QALYs were measured over that time, the last 200 years, they would clearly also follow a similar, and likely steeper, exponential increase. Not only has lifespan increased but quality of life has increased. While people are unaware of how much life has improved [41], poverty and related health issues have decreased outside the first world nations during the last 50 years [42].
With the rising global population and use of fossil fuels, there has been a causal rise in the global warming gas carbon dioxide (CO2). Earth CO2 atmospheric levels are now at 418 parts per million (ppm), a third higher than they were after world war II. Deleterious climate effects have already occurred [43] (e.g. acidification of the ocean, bleaching of coral reefs, sea level rise submerging island nations, increased hurricane activity, droughts, crop loss, famine). In 2006 Patz and Olson estimated that climate change had already caused 5,000,000 DALYs in a 30 year timeframe, which was mostly burdened by the developing countries [44]. Scientists are even more concerned about future tipping points which the earth would be unlikely to recover from for many decades. Recently Schneider et al. showed a level of 1,200 ppm CO2 could cause the disappearance of climate cooling clouds covering the ocean and result in 8°C (14F) rise in global temperature [45]. Such a dramatic change would melt all of Greenland and much (if not all) of Antarctica’s glaciers, raising sea level and flooding all coastal cities globally, in which roughly 20% of the world’s population lives.
When millions, or billions, of humans are affected by such a foreseeable super event the weightings of actionable paths forward often have large ranges of uncertainty. What is the likelihood of such an event happening and of suggested interventions preventing the negative effects? What will be the health consequences of such a large portion of the earth having to relocate. The situation becomes more dire the faster the migration of people has to happen. While sea level rise is universally understandable and viewable, a faster and perhaps more pernicious effect will likely be rising air temperature. While humans are amazingly adaptable to different temperature zones we do have an upper temperature limit, the wet-bulb temperature (TW) of 35°C (95°F). Above this temperature humans cannot shed heat, and if a region attained this temperature for extended periods it would be impossible for humans to live there without air conditioning. In a business-as-usual emission model, Representative Concentration Pathway (RCP) 8.5, parts of the Middle East and South Asia could regularly exceed this 35°C threshold in the near future [46, 47, 48]. Deaths have not historically been cataloged at or above this 35°C limit because lethal issues can occur before that temperature limit is reached. In 2020 Raymond et al. reviewed weather stations globally and found many TW around 31°C and two stations above the human limit of 35°C [49]. Most of these temperatures occurred for short periods, 1–2 hours, but a fearsome spike in TW was found to occur in some coastal locations where an afternoon breeze could bring in humidity from the water spiking the wet bulb temperature. Dubai is already planning a city that will be enclosed in a dome, called “Mall of the World” and cover 48 million square feet while taking 10 years to complete. This domed city would protect the citizenry from inhospitable heat, while acting in a second fashion as a place to study a closed ecosystem with an eye towards building cities on the moon or mars.
The value societies assign to growing their population can vary for a myriad of reasons, such as predominant religious doctrine. There has been recent excitement about human travel to the moon and mars, with permanent settlement on the latter. If there were a mars base with less than 10,000 people the QALY analysis to save a newborn compared to a 80 year old would likely be different than the same question on earth. In this thought experiment the fair innings would likely trump the rule of rescue on Mars when assigning health resources to young vs. old.
In the next 50–100 years humanity may have nearly unlimited resources: energy (e.g. solar panels, fusion) and robotics/machines to perform the necessary tasks for humans to thrive (e.g. farming food, building shelter, developing and raising children). Under such a paradigm the younger generation is not an imposition on older generations so there would not be as much of a downside to increasing birth rates. Humanity has historically seemed insatiable in its use of resources so such a paradigm may never arise, but if it did for even a few generations (somewhat like fossil fuels did for energy use at times) then QALYs would have to be fought over less as the world would be less of a zero sum game.
These extreme examples point out that QALYs between groups are useful to view how resources are assigned in different situations, highlighting societal norms that can override QALY analysis. It is fairly easy to determine the Life Years (LY) saved when measuring a QALY, harder to measure the Quality (Q), and perhaps hardest to incorporate the QALY to limit resource use in one area compared to another when confronted by societal norms that push against this.
A common modern occurrence in the United States is for an insured patient to receive a medical bill in which over 90% of the cost has been deducted through agreements between the insurance company and the medical supplier. The remaining bill is paid by the insurance company and the patients copay, or by the patient if they haven’t met their deductible limit. With people’s healthcare plan changing annually in the U.S. for multiple reasons (e.g. loss of job, changing job, moving to a different state, employer change in plan options, change in medical conditioning warranting upgrading or downgrading coverage), patients realistically rarely know the cost of medically covered procedures prior to obtaining care.
In the United States the lack of universal healthcare or a single payer system makes it harder to collect data on where and what healthcare dollars are being spent on. Large hospital systems are much better at measuring costs and expenditures within their network, than cities are at measuring the same across multiple networks. As an example between 2002 and 2016 patients with Heart Failure (HF) had a decrease in mortality (6.8% to 4.9%) and length of stay in a hospital (8.6 to 6.5 days) respectively. However they had an increase in cost per stay ($14,301 to $17,925) due to more extensive complications and procedures during the stay. At the same time their post-hospital expenses went up from 2002 to 2016 including discharge to long-term care (20.8% to 25.6%) [50]. Hospitals can save money by getting patients out the door quickly, but the society and patients are worse off if they leave the hospital only to encounter greater expenses and long-term discharge times.
The United States has held a privileged position in the world (militarily, financially, and societally) since the end of the second world war. Financially the U.S. has been able to borrow money both domestically and through foreign funds as the US dollar has been held as the global reserve currency. At times, such as during the Clinton presidency (1993–2001) there was economic prosperity and balanced budgets, at which time you see a leveling off of healthcare expenditure by %GDP (Figure 1). However, the vast majority of years the U.S. Congress has not been able to pass a balanced budget. This has allowed the U.S. to spend more on healthcare then there is money for, putting this debt on future generations. Perhaps the electorate would demand more of their elected officials if when economic successes were conveyed in the media they were scaled by how much debt was taken on to achieve them. For example, if healthcare coverage was increased by spending $X more for services, but that was during a year where the deficit (or borrowed money) was 20% higher than revenues, then the reported success should only be in funding a 80% * $X increase in healthcare support. The U.S. Revenue has been around 17% of GDP for the past 30 years, while spending has averaged about 20%. While congress has historically worried about deficits in the capital-B range (Billions) of US dollars, during the covid-19 pandemic both the Trump and succeeding Biden administration had relief packages in the capital-T (Trillion) dollar range. The fact that states generally keep balanced budgets, since they don’t have the legal means to print money like the fed, has kept future medical debt from being much worse.
Hospital administration, physicians, and patients can choose a very expensive procedure/surgery based on a perceived outcome which does not match the scientific outcome data. This misalignment can occur when a decision needs to be made quickly, the intervention has a positive short term outcome compared to longer term issue (such as reducing immediate pain), or for financial reasons if the hospital stands to benefit from a procedure covered by insurance. An example is the increase in the United States of C-section deliveries, compared to vaginal births, which rose from ~20% in the late 1990s to over 30% 15 years later [51]. In 2010 cesarean deliveries were 40% more expensive than vaginal deliveries, $9,905 versus $7,089 respectively [52]. Cesarean deliveries can reduce the incidence of pelvic floor disorders (PFD), namely stress urinary incontinence (SUI) and pelvic organ prolapse (POP), but the future savings do not offset the larger increase in delivery costs. The rate of SUI and POP after a vaginal birth are 13% and 14% respectively, but drop to 7% and 5% respectively after a cesarean birth. While the cost of surgeries for POP and SUI are expensive ($6,878 and $10,600 respectively) the relatively rare occurrence causes the average savings ($344 and $742 respectively) to be dwarfed by the higher delivery cost ($2,816) [52].
Human lifespan has doubled over the last 150 years, with the quality of those extra years also rising. However, the % of GDP spent on healthcare has more than doubled at a rate that is unsustainable to continue for the next 150 years. The concept of using QALYs to maximize quality with limited resources has gained acceptance in countries throughout the world. The country’s (e.g. in the E.U) with single payer systems are better situated to measure QALYs and use them to maximize quality of care compared to the United States. Societal norms, such as Rule of Rescue, prevent the maximum use of QALYs. The lack of transparency to prices and the ease with which the U.S. can borrow money has both made the use of QALYs difficult. As the costs, outcomes, and options of clinical interventions are made more clear and accessible to society writ large, the cost of healthcare can be lowered and average quality increased at a national level.
The authors declare no conflict of interest.
Affordable Care Act (also known as Obamacare) Chimeric Antigen Receptor T-cell therapy Chronic Lower Respiratory Disease Disability Adjusted Life Year In Vitro Fertilization National Council on Disability UK’s National Institute for Clinical Excellence Gross Domestic Product Heart Failure Pelvic Floor Disorder Pelvic Organ Prolapse Parts Per Million Quality Adjusted Life Expectancy Quality Adjusted Life Year Representative Concentration Pathway Stress Urinary Incontinence United States Dollar
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Aalborg University has Two Satellite Campuses, one in Copenhagen (Aalborg University Copenhagen) and the other in Esbjerg (Aalborg University Esbjerg).\n· He is a member of prestigious IEEE (Institute of Electrical and Electronics Engineers), and IAENG (International Association of Engineers) organizations. \n· He is the chief Editor of the Journal of Software Engineering.\n· He is the member of the Editorial Board of International Journal of Computer Science and Software Technology (IJCSST) and International Journal of Computer Engineering and Information Technology. \n· He is also the Editor of Communication in Computer and Information Science CCIS-20 by Springer.\n· Reviewer For Many Conferences\nHe is the lead person in making collaboration agreements between Aalborg University and many universities of Pakistan, for which the MOU’s (Memorandum of Understanding) have been signed.\nProfessor Akbar is working in Academia since 1990, he started his career as a Lab demonstrator/TA at the University of Sussex. After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. 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Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",institutionString:null,institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Bacterial Infectious Diseases",value:3,count:2},{group:"subseries",caption:"Parasitic Infectious Diseases",value:5,count:4},{group:"subseries",caption:"Viral Infectious Diseases",value:6,count:7}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:2},{group:"publicationYear",caption:"2021",value:2021,count:4},{group:"publicationYear",caption:"2020",value:2020,count:3},{group:"publicationYear",caption:"2019",value:2019,count:3},{group:"publicationYear",caption:"2018",value:2018,count:1}],authors:{paginationCount:120,paginationItems:[{id:"169608",title:"Prof.",name:"Marian",middleName:null,surname:"Găiceanu",slug:"marian-gaiceanu",fullName:"Marian Găiceanu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/169608/images/system/169608.png",biography:"Prof. Dr. Marian Gaiceanu graduated from the Naval and Electrical Engineering Faculty, Dunarea de Jos University of Galati, Romania, in 1997. He received a Ph.D. (Magna Cum Laude) in Electrical Engineering in 2002. Since 2017, Dr. Gaiceanu has been a Ph.D. supervisor for students in Electrical Engineering. He has been employed at Dunarea de Jos University of Galati since 1996, where he is currently a professor. Dr. Gaiceanu is a member of the National Council for Attesting Titles, Diplomas and Certificates, an expert of the Executive Agency for Higher Education, Research Funding, and a member of the Senate of the Dunarea de Jos University of Galati. He has been the head of the Integrated Energy Conversion Systems and Advanced Control of Complex Processes Research Center, Romania, since 2016. He has conducted several projects in power converter systems for electrical drives, power quality, PEM and SOFC fuel cell power converters for utilities, electric vehicles, and marine applications with the Department of Regulation and Control, SIEI S.pA. (2002–2004) and the Polytechnic University of Turin, Italy (2002–2004, 2006–2007). He is a member of the Institute of Electrical and Electronics Engineers (IEEE) and cofounder-member of the IEEE Power Electronics Romanian Chapter. He is a guest editor at Energies and an academic book editor for IntechOpen. He is also a member of the editorial boards of the Journal of Electrical Engineering, Electronics, Control and Computer Science and Sustainability. Dr. Gaiceanu has been General Chairman of the IEEE International Symposium on Electrical and Electronics Engineering in the last six editions.",institutionString:'"Dunarea de Jos" University of Galati',institution:{name:'"Dunarea de Jos" University of Galati',country:{name:"Romania"}}},{id:"4519",title:"Prof.",name:"Jaydip",middleName:null,surname:"Sen",slug:"jaydip-sen",fullName:"Jaydip Sen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/4519/images/system/4519.jpeg",biography:"Jaydip Sen is associated with Praxis Business School, Kolkata, India, as a professor in the Department of Data Science. His research areas include security and privacy issues in computing and communication, intrusion detection systems, machine learning, deep learning, and artificial intelligence in the financial domain. He has more than 200 publications in reputed international journals, refereed conference proceedings, and 20 book chapters in books published by internationally renowned publishing houses, such as Springer, CRC press, IGI Global, etc. Currently, he is serving on the editorial board of the prestigious journal Frontiers in Communications and Networks and in the technical program committees of a number of high-ranked international conferences organized by the IEEE, USA, and the ACM, USA. He has been listed among the top 2% of scientists in the world for the last three consecutive years, 2019 to 2021 as per studies conducted by the Stanford University, USA.",institutionString:"Praxis Business School",institution:null},{id:"320071",title:"Dr.",name:"Sidra",middleName:null,surname:"Mehtab",slug:"sidra-mehtab",fullName:"Sidra Mehtab",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00002v6KHoQAM/Profile_Picture_1584512086360",biography:"Sidra Mehtab has completed her BS with honors in Physics from Calcutta University, India in 2018. She has done MS in Data Science and Analytics from Maulana Abul Kalam Azad University of Technology (MAKAUT), Kolkata, India in 2020. Her research areas include Econometrics, Time Series Analysis, Machine Learning, Deep Learning, Artificial Intelligence, and Computer and Network Security with a particular focus on Cyber Security Analytics. Ms. Mehtab has published seven papers in international conferences and one of her papers has been accepted for publication in a reputable international journal. She has won the best paper awards in two prestigious international conferences – BAICONF 2019, and ICADCML 2021, organized in the Indian Institute of Management, Bangalore, India in December 2019, and SOA University, Bhubaneswar, India in January 2021. Besides, Ms. Mehtab has also published two book chapters in two books. Seven of her book chapters will be published in a volume shortly in 2021 by Cambridge Scholars’ Press, UK. Currently, she is working as the joint editor of two edited volumes on Time Series Analysis and Forecasting to be published in the first half of 2021 by an international house. Currently, she is working as a Data Scientist with an MNC in Delhi, India.",institutionString:"NSHM College of Management and Technology",institution:null},{id:"226240",title:"Dr.",name:"Andri Irfan",middleName:null,surname:"Rifai",slug:"andri-irfan-rifai",fullName:"Andri Irfan Rifai",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/226240/images/7412_n.jpg",biography:"Andri IRFAN is a Senior Lecturer of Civil Engineering and Planning. He completed the PhD at the Universitas Indonesia & Universidade do Minho with Sandwich Program Scholarship from the Directorate General of Higher Education and LPDP scholarship. He has been teaching for more than 19 years and much active to applied his knowledge in the project construction in Indonesia. His research interest ranges from pavement management system to advanced data mining techniques for transportation engineering. He has published more than 50 papers in journals and 2 books.",institutionString:null,institution:{name:"Universitas Internasional Batam",country:{name:"Indonesia"}}},{id:"314576",title:"Dr.",name:"Ibai",middleName:null,surname:"Laña",slug:"ibai-lana",fullName:"Ibai Laña",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/314576/images/system/314576.jpg",biography:"Dr. Ibai Laña works at TECNALIA as a data analyst. He received his Ph.D. in Artificial Intelligence from the University of the Basque Country (UPV/EHU), Spain, in 2018. He is currently a senior researcher at TECNALIA. His research interests fall within the intersection of intelligent transportation systems, machine learning, traffic data analysis, and data science. He has dealt with urban traffic forecasting problems, applying machine learning models and evolutionary algorithms. He has experience in origin-destination matrix estimation or point of interest and trajectory detection. Working with large volumes of data has given him a good command of big data processing tools and NoSQL databases. He has also been a visiting scholar at the Knowledge Engineering and Discovery Research Institute, Auckland University of Technology.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"314575",title:"Dr.",name:"Jesus",middleName:null,surname:"L. Lobo",slug:"jesus-l.-lobo",fullName:"Jesus L. Lobo",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/314575/images/system/314575.png",biography:"Dr. Jesús López is currently based in Bilbao (Spain) working at TECNALIA as Artificial Intelligence Research Scientist. In most cases, a project idea or a new research line needs to be investigated to see if it is good enough to take into production or to focus on it. That is exactly what he does, diving into Machine Learning algorithms and technologies to help TECNALIA to decide whether something is great in theory or will actually impact on the product or processes of its projects. So, he is expert at framing experiments, developing hypotheses, and proving whether they’re true or not, in order to investigate fundamental problems with a longer time horizon. He is also able to design and develop PoCs and system prototypes in simulation. He has participated in several national and internacional R&D projects.\n\nAs another relevant part of his everyday research work, he usually publishes his findings in reputed scientific refereed journals and international conferences, occasionally acting as reviewer and Programme Commitee member. Concretely, since 2018 he has published 9 JCR (8 Q1) journal papers, 9 conference papers (e.g. ECML PKDD 2021), and he has co-edited a book. He is also active in popular science writing data science stories for reputed blogs (KDNuggets, TowardsDataScience, Naukas). Besides, he has recently embarked on mentoring programmes as mentor, and has also worked as data science trainer.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"339677",title:"Dr.",name:"Mrinmoy",middleName:null,surname:"Roy",slug:"mrinmoy-roy",fullName:"Mrinmoy Roy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/339677/images/16768_n.jpg",biography:"An accomplished Sales & Marketing professional with 12 years of cross-functional experience in well-known organisations such as CIPLA, LUPIN, GLENMARK, ASTRAZENECA across different segment of Sales & Marketing, International Business, Institutional Business, Product Management, Strategic Marketing of HIV, Oncology, Derma, Respiratory, Anti-Diabetic, Nutraceutical & Stomatological Product Portfolio and Generic as well as Chronic Critical Care Portfolio. A First Class MBA in International Business & Strategic Marketing, B.Pharm, D.Pharm, Google Certified Digital Marketing Professional. Qualified PhD Candidate in Operations and Management with special focus on Artificial Intelligence and Machine Learning adoption, analysis and use in Healthcare, Hospital & Pharma Domain. Seasoned with diverse therapy area of Pharmaceutical Sales & Marketing ranging from generating revenue through generating prescriptions, launching new products, and making them big brands with continuous strategy execution at the Physician and Patients level. Moved from Sales to Marketing and Business Development for 3.5 years in South East Asian Market operating from Manila, Philippines. Came back to India and handled and developed Brands such as Gluconorm, Lupisulin, Supracal, Absolut Woman, Hemozink, Fabiflu (For COVID 19), and many more. In my previous assignment I used to develop and execute strategies on Sales & Marketing, Commercialization & Business Development for Institution and Corporate Hospital Business portfolio of Oncology Therapy Area for AstraZeneca Pharma India Ltd. Being a Research Scholar and Student of ‘Operations Research & Management: Artificial Intelligence’ I published several pioneer research papers and book chapters on the same in Internationally reputed journals and Books indexed in Scopus, Springer and Ei Compendex, Google Scholar etc. Currently, I am launching PGDM Pharmaceutical Management Program in IIHMR Bangalore and spearheading the course curriculum and structure of the same. I am interested in Collaboration for Healthcare Innovation, Pharma AI Innovation, Future trend in Marketing and Management with incubation on Healthcare, Healthcare IT startups, AI-ML Modelling and Healthcare Algorithm based training module development. I am also an affiliated member of the Institute of Management Consultant of India, looking forward to Healthcare, Healthcare IT and Innovation, Pharma and Hospital Management Consulting works.",institutionString:null,institution:{name:"Lovely Professional University",country:{name:"India"}}},{id:"1063",title:"Prof.",name:"Constantin",middleName:null,surname:"Volosencu",slug:"constantin-volosencu",fullName:"Constantin Volosencu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/1063/images/system/1063.png",biography:"Prof. Dr. Constantin Voloşencu graduated as an engineer from\nPolitehnica University of Timișoara, Romania, where he also\nobtained a doctorate degree. He is currently a full professor in\nthe Department of Automation and Applied Informatics at the\nsame university. Dr. Voloşencu is the author of ten books, seven\nbook chapters, and more than 160 papers published in journals\nand conference proceedings. He has also edited twelve books and\nhas twenty-seven patents to his name. He is a manager of research grants, editor in\nchief and member of international journal editorial boards, a former plenary speaker, a member of scientific committees, and chair at international conferences. His\nresearch is in the fields of control systems, control of electric drives, fuzzy control\nsystems, neural network applications, fault detection and diagnosis, sensor network\napplications, monitoring of distributed parameter systems, and power ultrasound\napplications. He has developed automation equipment for machine tools, spooling\nmachines, high-power ultrasound processes, and more.",institutionString:"Polytechnic University of Timişoara",institution:{name:"Polytechnic University of Timişoara",country:{name:"Romania"}}},{id:"221364",title:"Dr.",name:"Eneko",middleName:null,surname:"Osaba",slug:"eneko-osaba",fullName:"Eneko Osaba",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/221364/images/system/221364.jpg",biography:"Dr. Eneko Osaba works at TECNALIA as a senior researcher. He obtained his Ph.D. in Artificial Intelligence in 2015. He has participated in more than twenty-five local and European research projects, and in the publication of more than 130 papers. He has performed several stays at universities in the United Kingdom, Italy, and Malta. Dr. Osaba has served as a program committee member in more than forty international conferences and participated in organizing activities in more than ten international conferences. He is a member of the editorial board of the International Journal of Artificial Intelligence, Data in Brief, and Journal of Advanced Transportation. He is also a guest editor for the Journal of Computational Science, Neurocomputing, Swarm, and Evolutionary Computation and IEEE ITS Magazine.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"275829",title:"Dr.",name:"Esther",middleName:null,surname:"Villar-Rodriguez",slug:"esther-villar-rodriguez",fullName:"Esther Villar-Rodriguez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/275829/images/system/275829.jpg",biography:"Dr. Esther Villar obtained a Ph.D. in Information and Communication Technologies from the University of Alcalá, Spain, in 2015. She obtained a degree in Computer Science from the University of Deusto, Spain, in 2010, and an MSc in Computer Languages and Systems from the National University of Distance Education, Spain, in 2012. Her areas of interest and knowledge include natural language processing (NLP), detection of impersonation in social networks, semantic web, and machine learning. Dr. Esther Villar made several contributions at conferences and publishing in various journals in those fields. Currently, she is working within the OPTIMA (Optimization Modeling & Analytics) business of TECNALIA’s ICT Division as a data scientist in projects related to the prediction and optimization of management and industrial processes (resource planning, energy efficiency, etc).",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"49813",title:"Dr.",name:"Javier",middleName:null,surname:"Del Ser",slug:"javier-del-ser",fullName:"Javier Del Ser",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49813/images/system/49813.png",biography:"Prof. Dr. Javier Del Ser received his first PhD in Telecommunication Engineering (Cum Laude) from the University of Navarra, Spain, in 2006, and a second PhD in Computational Intelligence (Summa Cum Laude) from the University of Alcala, Spain, in 2013. He is currently a principal researcher in data analytics and optimisation at TECNALIA (Spain), a visiting fellow at the Basque Center for Applied Mathematics (BCAM) and a part-time lecturer at the University of the Basque Country (UPV/EHU). His research interests gravitate on the use of descriptive, prescriptive and predictive algorithms for data mining and optimization in a diverse range of application fields such as Energy, Transport, Telecommunications, Health and Industry, among others. In these fields he has published more than 240 articles, co-supervised 8 Ph.D. theses, edited 6 books, coauthored 7 patents and participated/led more than 40 research projects. He is a Senior Member of the IEEE, and a recipient of the Biscay Talent prize for his academic career.",institutionString:"Tecnalia Research & Innovation",institution:null},{id:"278948",title:"Dr.",name:"Carlos Pedro",middleName:null,surname:"Gonçalves",slug:"carlos-pedro-goncalves",fullName:"Carlos Pedro Gonçalves",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRcmyQAC/Profile_Picture_1564224512145",biography:'Carlos Pedro Gonçalves (PhD) is an Associate Professor at Lusophone University of Humanities and Technologies and a researcher on Complexity Sciences, Quantum Technologies, Artificial Intelligence, Strategic Studies, Studies in Intelligence and Security, FinTech and Financial Risk Modeling. He is also a progammer with programming experience in:\n\nA) Quantum Computing using Qiskit Python module and IBM Quantum Experience Platform, with software developed on the simulation of Quantum Artificial Neural Networks and Quantum Cybersecurity;\n\nB) Artificial Intelligence and Machine learning programming in Python;\n\nC) Artificial Intelligence, Multiagent Systems Modeling and System Dynamics Modeling in Netlogo, with models developed in the areas of Chaos Theory, Econophysics, Artificial Intelligence, Classical and Quantum Complex Systems Science, with the Econophysics models having been cited worldwide and incorporated in PhD programs by different Universities.\n\nReceived an Arctic Code Vault Contributor status by GitHub, due to having developed open source software preserved in the \\"Arctic Code Vault\\" for future generations (https://archiveprogram.github.com/arctic-vault/), with the Strategy Analyzer A.I. module for decision making support (based on his PhD thesis, used in his Classes on Decision Making and in Strategic Intelligence Consulting Activities) and QNeural Python Quantum Neural Network simulator also preserved in the \\"Arctic Code Vault\\", for access to these software modules see: https://github.com/cpgoncalves. He is also a peer reviewer with outsanding review status from Elsevier journals, including Physica A, Neurocomputing and Engineering Applications of Artificial Intelligence. Science CV available at: https://www.cienciavitae.pt//pt/8E1C-A8B3-78C5 and ORCID: https://orcid.org/0000-0002-0298-3974',institutionString:"University of Lisbon",institution:{name:"Universidade Lusófona",country:{name:"Portugal"}}},{id:"241400",title:"Prof.",name:"Mohammed",middleName:null,surname:"Bsiss",slug:"mohammed-bsiss",fullName:"Mohammed Bsiss",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/241400/images/8062_n.jpg",biography:null,institutionString:null,institution:null},{id:"276128",title:"Dr.",name:"Hira",middleName:null,surname:"Fatima",slug:"hira-fatima",fullName:"Hira Fatima",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/276128/images/14420_n.jpg",biography:"Dr. Hira Fatima\nAssistant Professor\nDepartment of Mathematics\nInstitute of Applied Science\nMangalayatan University, Aligarh\nMobile: no : 8532041179\nhirafatima2014@gmal.com\n\nDr. Hira Fatima has received his Ph.D. degree in pure Mathematics from Aligarh Muslim University, Aligarh India. Currently working as an Assistant Professor in the Department of Mathematics, Institute of Applied Science, Mangalayatan University, Aligarh. She taught so many courses of Mathematics of UG and PG level. Her research Area of Expertise is Functional Analysis & Sequence Spaces. She has been working on Ideal Convergence of double sequence. She has published 17 research papers in National and International Journals including Cogent Mathematics, Filomat, Journal of Intelligent and Fuzzy Systems, Advances in Difference Equations, Journal of Mathematical Analysis, Journal of Mathematical & Computer Science etc. She has also reviewed few research papers for the and international journals. She is a member of Indian Mathematical Society.",institutionString:null,institution:null},{id:"302698",title:"Dr.",name:"Yao",middleName:null,surname:"Shan",slug:"yao-shan",fullName:"Yao Shan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Dalian University of Technology",country:{name:"China"}}},{id:"125911",title:"Prof.",name:"Jia-Ching",middleName:null,surname:"Wang",slug:"jia-ching-wang",fullName:"Jia-Ching Wang",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"National Central University",country:{name:"Taiwan"}}},{id:"357085",title:"Mr.",name:"P. Mohan",middleName:null,surname:"Anand",slug:"p.-mohan-anand",fullName:"P. Mohan Anand",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Indian Institute of Technology Kanpur",country:{name:"India"}}},{id:"356696",title:"Ph.D. Student",name:"P.V.",middleName:null,surname:"Sai Charan",slug:"p.v.-sai-charan",fullName:"P.V. Sai Charan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Indian Institute of Technology Kanpur",country:{name:"India"}}},{id:"357086",title:"Prof.",name:"Sandeep K.",middleName:null,surname:"Shukla",slug:"sandeep-k.-shukla",fullName:"Sandeep K. Shukla",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Indian Institute of Technology Kanpur",country:{name:"India"}}},{id:"356823",title:"MSc.",name:"Seonghee",middleName:null,surname:"Min",slug:"seonghee-min",fullName:"Seonghee Min",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Daegu University",country:{name:"Korea, South"}}},{id:"353307",title:"Prof.",name:"Yoosoo",middleName:null,surname:"Oh",slug:"yoosoo-oh",fullName:"Yoosoo Oh",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:"Yoosoo Oh received his Bachelor's degree in the Department of Electronics and Engineering from Kyungpook National University in 2002. He obtained his Master’s degree in the Department of Information and Communications from Gwangju Institute of Science and Technology (GIST) in 2003. In 2010, he received his Ph.D. degree in the School of Information and Mechatronics from GIST. In the meantime, he was an executed team leader at Culture Technology Institute, GIST, 2010-2012. In 2011, he worked at Lancaster University, the UK as a visiting scholar. In September 2012, he joined Daegu University, where he is currently an associate professor in the School of ICT Conver, Daegu University. Also, he served as the Board of Directors of KSIIS since 2019, and HCI Korea since 2016. From 2017~2019, he worked as a center director of the Mixed Reality Convergence Research Center at Daegu University. From 2015-2017, He worked as a director in the Enterprise Supporting Office of LINC Project Group, Daegu University. His research interests include Activity Fusion & Reasoning, Machine Learning, Context-aware Middleware, Human-Computer Interaction, etc.",institutionString:null,institution:{name:"Daegu Gyeongbuk Institute of Science and Technology",country:{name:"Korea, South"}}},{id:"262719",title:"Dr.",name:"Esma",middleName:null,surname:"Ergüner Özkoç",slug:"esma-erguner-ozkoc",fullName:"Esma Ergüner Özkoç",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Başkent University",country:{name:"Turkey"}}},{id:"419199",title:"Dr.",name:"Qun",middleName:null,surname:"Yang",slug:"qun-yang",fullName:"Qun Yang",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Auckland",country:{name:"New Zealand"}}},{id:"351158",title:"Prof.",name:"David W.",middleName:null,surname:"Anderson",slug:"david-w.-anderson",fullName:"David W. 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The motor of the society is the industry and the research of this topic has to be empowered in order to increase and improve the quality of our lives.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/22.jpg",keywords:"Machine Learning, Intelligence Algorithms, Data Science, Artificial Intelligence, Applications on Applied Intelligence"},{id:"23",title:"Computational Neuroscience",scope:"Computational neuroscience focuses on biologically realistic abstractions and models validated and solved through computational simulations to understand principles for the development, structure, physiology, and ability of the nervous system. This topic is dedicated to biologically plausible descriptions and computational models - at various abstraction levels - of neurons and neural systems. This includes, but is not limited to: single-neuron modeling, sensory processing, motor control, memory, and synaptic plasticity, attention, identification, categorization, discrimination, learning, development, axonal patterning, guidance, neural architecture, behaviors, and dynamics of networks, cognition and the neuroscientific basis of consciousness. 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Novel computational algorithms for image analysis, scene understanding, biometrics, deep learning and their software or hardware implementations for natural and medical images, robotics, VR/AR, applications are some research directions relevant to this topic.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/24.jpg",keywords:"Image Analysis, Scene Understanding, Biometrics, Deep Learning, Software Implementation, Hardware Implementation, Natural Images, Medical Images, Robotics, VR/AR"},{id:"25",title:"Evolutionary Computation",scope:"Evolutionary computing is a paradigm that has grown dramatically in recent years. This group of bio-inspired metaheuristics solves multiple optimization problems by applying the metaphor of natural selection. It so far has solved problems such as resource allocation, routing, schedule planning, and engineering design. Moreover, in the field of machine learning, evolutionary computation has carved out a significant niche both in the generation of learning models and in the automatic design and optimization of hyperparameters in deep learning models. This collection aims to include quality volumes on various topics related to evolutionary algorithms and, alternatively, other metaheuristics of interest inspired by nature. For example, some of the issues of interest could be the following: Advances in evolutionary computation (Genetic algorithms, Genetic programming, Bio-inspired metaheuristics, Hybrid metaheuristics, Parallel ECs); Applications of evolutionary algorithms (Machine learning and Data Mining with EAs, Search-Based Software Engineering, Scheduling, and Planning Applications, Smart Transport Applications, Applications to Games, Image Analysis, Signal Processing and Pattern Recognition, Applications to Sustainability).",coverUrl:"https://cdn.intechopen.com/series_topics/covers/25.jpg",keywords:"Genetic Algorithms, Genetic Programming, Evolutionary Programming, Evolution Strategies, Hybrid Algorithms, Bioinspired Metaheuristics, Ant Colony Optimization, Evolutionary Learning, Hyperparameter Optimization"},{id:"26",title:"Machine Learning and Data Mining",scope:"The scope of machine learning and data mining is immense and is growing every day. It has become a massive part of our daily lives, making predictions based on experience, making this a fascinating area that solves problems that otherwise would not be possible or easy to solve. This topic aims to encompass algorithms that learn from experience (supervised and unsupervised), improve their performance over time and enable machines to make data-driven decisions. It is not limited to any particular applications, but contributions are encouraged from all disciplines.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/26.jpg",keywords:"Intelligent Systems, Machine Learning, Data Science, Data Mining, Artificial Intelligence"},{id:"27",title:"Multi-Agent Systems",scope:"Multi-agent systems are recognised as a state of the art field in Artificial Intelligence studies, which is popular due to the usefulness in facilitation capabilities to handle real-world problem-solving in a distributed fashion. The area covers many techniques that offer solutions to emerging problems in robotics and enterprise-level software systems. Collaborative intelligence is highly and effectively achieved with multi-agent systems. Areas of application include swarms of robots, flocks of UAVs, collaborative software management. Given the level of technological enhancements, the popularity of machine learning in use has opened a new chapter in multi-agent studies alongside the practical challenges and long-lasting collaboration issues in the field. It has increased the urgency and the need for further studies in this field. We welcome chapters presenting research on the many applications of multi-agent studies including, but not limited to, the following key areas: machine learning for multi-agent systems; modeling swarms robots and flocks of UAVs with multi-agent systems; decision science and multi-agent systems; software engineering for and with multi-agent systems; tools and technologies of multi-agent systems.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/27.jpg",keywords:"Collaborative Intelligence, Learning, Distributed Control System, Swarm Robotics, Decision Science, Software Engineering"}],annualVolumeBook:{},thematicCollection:[],selectedSeries:{title:"Artificial Intelligence",id:"14"},selectedSubseries:null},seriesLanding:{item:{id:"7",title:"Biomedical Engineering",doi:"10.5772/intechopen.71985",issn:"2631-5343",scope:"Biomedical Engineering is one of the fastest-growing interdisciplinary branches of science and industry. The combination of electronics and computer science with biology and medicine has improved patient diagnosis, reduced rehabilitation time, and helped to facilitate a better quality of life. Nowadays, all medical imaging devices, medical instruments, or new laboratory techniques result from the cooperation of specialists in various fields. The series of Biomedical Engineering books covers such areas of knowledge as chemistry, physics, electronics, medicine, and biology. This series is intended for doctors, engineers, and scientists involved in biomedical engineering or those wanting to start working in this field.",coverUrl:"https://cdn.intechopen.com/series/covers/7.jpg",latestPublicationDate:"May 7th, 2022",hasOnlineFirst:!0,numberOfOpenTopics:3,numberOfPublishedChapters:96,numberOfPublishedBooks:12,editor:{id:"50150",title:"Prof.",name:"Robert",middleName:null,surname:"Koprowski",fullName:"Robert Koprowski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYTYNQA4/Profile_Picture_1630478535317",biography:"Robert Koprowski, MD (1997), PhD (2003), Habilitation (2015), is an employee of the University of Silesia, Poland, Institute of Computer Science, Department of Biomedical Computer Systems. For 20 years, he has studied the analysis and processing of biomedical images, emphasizing the full automation of measurement for a large inter-individual variability of patients. Dr. Koprowski has authored more than a hundred research papers with dozens in impact factor (IF) journals and has authored or co-authored six books. Additionally, he is the author of several national and international patents in the field of biomedical devices and imaging. Since 2011, he has been a reviewer of grants and projects (including EU projects) in biomedical engineering.",institutionString:null,institution:{name:"University of Silesia",institutionURL:null,country:{name:"Poland"}}},subseries:[{id:"7",title:"Bioinformatics and Medical Informatics",keywords:"Biomedical Data, Drug Discovery, Clinical Diagnostics, Decoding Human Genome, AI in Personalized Medicine, Disease-prevention Strategies, Big Data Analysis in Medicine",scope:"Bioinformatics aims to help understand the functioning of the mechanisms of living organisms through the construction and use of quantitative tools. The applications of this research cover many related fields, such as biotechnology and medicine, where, for example, Bioinformatics contributes to faster drug design, DNA analysis in forensics, and DNA sequence analysis in the field of personalized medicine. Personalized medicine is a type of medical care in which treatment is customized individually for each patient. Personalized medicine enables more effective therapy, reduces the costs of therapy and clinical trials, and also minimizes the risk of side effects. Nevertheless, advances in personalized medicine would not have been possible without bioinformatics, which can analyze the human genome and other vast amounts of biomedical data, especially in genetics. The rapid growth of information technology enabled the development of new tools to decode human genomes, large-scale studies of genetic variations and medical informatics. The considerable development of technology, including the computing power of computers, is also conducive to the development of bioinformatics, including personalized medicine. In an era of rapidly growing data volumes and ever lower costs of generating, storing and computing data, personalized medicine holds great promises. Modern computational methods used as bioinformatics tools can integrate multi-scale, multi-modal and longitudinal patient data to create even more effective and safer therapy and disease prevention methods. Main aspects of the topic are: Applying bioinformatics in drug discovery and development; Bioinformatics in clinical diagnostics (genetic variants that act as markers for a condition or a disease); Blockchain and Artificial Intelligence/Machine Learning in personalized medicine; Customize disease-prevention strategies in personalized medicine; Big data analysis in personalized medicine; Translating stratification algorithms into clinical practice of personalized medicine.",annualVolume:11403,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/7.jpg",editor:{id:"351533",title:"Dr.",name:"Slawomir",middleName:null,surname:"Wilczynski",fullName:"Slawomir Wilczynski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035U1loQAC/Profile_Picture_1630074514792",institutionString:null,institution:{name:"Medical University of Silesia",institutionURL:null,country:{name:"Poland"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"5886",title:"Dr.",name:"Alexandros",middleName:"T.",surname:"Tzallas",fullName:"Alexandros Tzallas",profilePictureURL:"https://mts.intechopen.com/storage/users/5886/images/system/5886.png",institutionString:"University of Ioannina, Greece & Imperial College London",institution:{name:"University of Ioannina",institutionURL:null,country:{name:"Greece"}}},{id:"257388",title:"Distinguished Prof.",name:"Lulu",middleName:null,surname:"Wang",fullName:"Lulu Wang",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRX6kQAG/Profile_Picture_1630329584194",institutionString:null,institution:{name:"Shenzhen Technology University",institutionURL:null,country:{name:"China"}}},{id:"225387",title:"Prof.",name:"Reda",middleName:"R.",surname:"Gharieb",fullName:"Reda Gharieb",profilePictureURL:"https://mts.intechopen.com/storage/users/225387/images/system/225387.jpg",institutionString:"Assiut University",institution:{name:"Assiut University",institutionURL:null,country:{name:"Egypt"}}}]},{id:"8",title:"Bioinspired Technology and Biomechanics",keywords:"Bioinspired Systems, Biomechanics, Assistive Technology, Rehabilitation",scope:'Bioinspired technologies take advantage of understanding the actual biological system to provide solutions to problems in several areas. Recently, bioinspired systems have been successfully employing biomechanics to develop and improve assistive technology and rehabilitation devices. The research topic "Bioinspired Technology and Biomechanics" welcomes studies reporting recent advances in bioinspired technologies that contribute to individuals\' health, inclusion, and rehabilitation. Possible contributions can address (but are not limited to) the following research topics: Bioinspired design and control of exoskeletons, orthoses, and prostheses; Experimental evaluation of the effect of assistive devices (e.g., influence on gait, balance, and neuromuscular system); Bioinspired technologies for rehabilitation, including clinical studies reporting evaluations; Application of neuromuscular and biomechanical models to the development of bioinspired technology.',annualVolume:11404,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/8.jpg",editor:{id:"144937",title:"Prof.",name:"Adriano",middleName:"De Oliveira",surname:"Andrade",fullName:"Adriano Andrade",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRC8QQAW/Profile_Picture_1625219101815",institutionString:null,institution:{name:"Federal University of Uberlândia",institutionURL:null,country:{name:"Brazil"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"49517",title:"Prof.",name:"Hitoshi",middleName:null,surname:"Tsunashima",fullName:"Hitoshi Tsunashima",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYTP4QAO/Profile_Picture_1625819726528",institutionString:null,institution:{name:"Nihon University",institutionURL:null,country:{name:"Japan"}}},{id:"425354",title:"Dr.",name:"Marcus",middleName:"Fraga",surname:"Vieira",fullName:"Marcus Vieira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003BJSgIQAX/Profile_Picture_1627904687309",institutionString:null,institution:{name:"Universidade Federal de Goiás",institutionURL:null,country:{name:"Brazil"}}},{id:"196746",title:"Dr.",name:"Ramana",middleName:null,surname:"Vinjamuri",fullName:"Ramana Vinjamuri",profilePictureURL:"https://mts.intechopen.com/storage/users/196746/images/system/196746.jpeg",institutionString:"University of Maryland, Baltimore County",institution:{name:"University of Maryland, Baltimore County",institutionURL:null,country:{name:"United States of America"}}}]},{id:"9",title:"Biotechnology - Biosensors, Biomaterials and Tissue Engineering",keywords:"Biotechnology, Biosensors, Biomaterials, Tissue Engineering",scope:"The Biotechnology - Biosensors, Biomaterials and Tissue Engineering topic within the Biomedical Engineering Series aims to rapidly publish contributions on all aspects of biotechnology, biosensors, biomaterial and tissue engineering. We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics can include but are not limited to: Biotechnology such as biotechnological products and process engineering; Biotechnologically relevant enzymes and proteins; Bioenergy and biofuels; Applied genetics and molecular biotechnology; Genomics, transcriptomics, proteomics; Applied microbial and cell physiology; Environmental biotechnology; Methods and protocols. Moreover, topics in biosensor technology, like sensors that incorporate enzymes, antibodies, nucleic acids, whole cells, tissues and organelles, and other biological or biologically inspired components will be considered, and topics exploring transducers, including those based on electrochemical and optical piezoelectric, thermal, magnetic, and micromechanical elements. Chapters exploring biomaterial approaches such as polymer synthesis and characterization, drug and gene vector design, biocompatibility, immunology and toxicology, and self-assembly at the nanoscale, are welcome. Finally, the tissue engineering subcategory will support topics such as the fundamentals of stem cells and progenitor cells and their proliferation, differentiation, bioreactors for three-dimensional culture and studies of phenotypic changes, stem and progenitor cells, both short and long term, ex vivo and in vivo implantation both in preclinical models and also in clinical trials.",annualVolume:11405,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/9.jpg",editor:{id:"126286",title:"Dr.",name:"Luis",middleName:"Jesús",surname:"Villarreal-Gómez",fullName:"Luis Villarreal-Gómez",profilePictureURL:"https://mts.intechopen.com/storage/users/126286/images/system/126286.jpg",institutionString:null,institution:{name:"Autonomous University of Baja California",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"35539",title:"Dr.",name:"Cecilia",middleName:null,surname:"Cristea",fullName:"Cecilia Cristea",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYQ65QAG/Profile_Picture_1621007741527",institutionString:null,institution:{name:"Iuliu Hațieganu University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"40735",title:"Dr.",name:"Gil",middleName:"Alberto Batista",surname:"Gonçalves",fullName:"Gil Gonçalves",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYRLGQA4/Profile_Picture_1628492612759",institutionString:null,institution:{name:"University of Aveiro",institutionURL:null,country:{name:"Portugal"}}},{id:"211725",title:"Associate Prof.",name:"Johann F.",middleName:null,surname:"Osma",fullName:"Johann F. 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