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Multilevel cervical disc pathology is defined as two or more segments of the cervical spine that have herniated, or degenerated, which are subsequently causing significant axial pain with radiculopathy, resulting in disability and a loss of productivity. Anterior cervical discectomy and fusion (ACDF) is considered the gold standard treatment for multilevel cervical spondylosis. However there are some long term drawbacks involving the development of subsidence, pseudarthrosis and the degeneration of adjacent segments [1, 2, 3, 4]. Cervical artificial disc replacement (C-ADR) has been demonstrated to be a safe and effective means of treating single-level or multilevel cervical disc pathology by several prospective studies from the United States Food and Drug Administration and by some meta-analyses [5, 6, 7, 8, 9, 10, 11]. In patients who have multilevel pathology, there is a growing enthusiasm towards definitive management in the form of a cervical hybrid arthroplasty [12, 13, 14, 15]. The cervical hybrid arthroplasty is a procedure wherein an artificial disc replacement can be placed at one level, with a cervical fusion device implanted at another nearby injured disc. Figure 1.\n
\nThe cervical hybrid arthroplasty.
While indications for both fusions and arthroplasty are always in a state of flux certain considerations can be made to this point. Both implants share similar clinical goals of decreased pain with increased function, and therefore there is considerable overlap in regards to their surgical indications. As a general rule both fusions and arthroplasty can be indicated for any skeletally mature patient who has neck pain and/or radiculopathy which has failed a course of six weeks of conservative nonoperative therapy. Nonoperative treatments vary among medication, therapy, traction, chiropractic, acupuncture, activity modification, epidural injections and pain management.
\nCervical hybrid arthroplasty Inclusion Criteria:
Has cervical disc pathology at two [2] cervical levels (from C3 C7) requiring surgical treatment and involving intractable radiculopathy, neck pain and/or myelopathy.
Has a herniated disc and/or osteophyte formation at each level to be treated that is producing symptomatic nerve root and/or spinal cord compression. The pathology correlates directly with documented findings on patient history and exam (e.g., neck pain with arm pain, functional deficit and/or neurological deficit), and the requirement for surgical treatment is confirmed by imaging studies (e.g., MRI, CT, x-rays, etc.).
Has the presence of progressive symptoms or signs of nerve root/spinal cord compression despite continued non-operative management.
Has no prior surgical intervention at the involved levels or any subsequent planned/staged surgical procedure at the involved or adjacent level(s).
The cervical disc arthroplasty implant can be considered for symptomatic patients within the earlier stages of disc pathology, prior to bony collapse and significant spurring in order to limit postoperative heterotopic ossification.
Must be at least 18 years of age and be skeletally mature at the time of surgery
Often with cervical pathology a fusion based implant is warranted, so for the purpose of this chapter we will set our focus on contraindications specific to the arthroplasty implant.
Advanced abnormal changes such as bony collapse at the proposed surgery level.
Advanced degeneration or trauma to the facet joints on the back of the spine.
An active systemic infection or infection at the surgical site.
An unnatural shape (e.g. hyperkyphosis deformity, hyperlordosis deformity) of the neck.
A known allergy to titanium, stainless steel, polyurethane, polyethylene or ethylene oxide residuals.
A known allergy to PEEK, ceramic, or the given implants requisite metallurgy.
Has documented or diagnosed cervical instability relative to adjacent segments at either level, defined by dynamic (flexion/extension) radiographs showing:
Sagittal plane translation >3.5 mm, or
Sagittal plane angulation >20°;
Has severe pathology of the facet joints of the involved vertebral bodies.
Has been previously diagnosed with osteopenia or osteomalacia.
Has been previously diagnosed with diagnosis of osteoporosis.
If the level of bone mineral density is a T score of −1.5 or lower.
Has presence of spinal metastases.
Has overt or active bacterial infection, either local or systemic.
Has chronic or acute renal failure or prior history of renal disease.
Has received drugs or therapies that may interfere with bone metabolism within two weeks prior to the planned date of spinal surgery (e.g., chemotherapy, radiation, steroids or methotrexate), excluding routine perioperative anti-inflammatory drugs.
Has a history of an endocrine or metabolic disorder known to affect osteogenesis (e.g., Paget’s Disease, renal osteodystrophy, Ehlers-Danlos Syndrome, or osteogenesis imperfecta).
Has a condition that requires postoperative medications that interfere with the stability of the implant, such as steroids, chemotherapy, or radiation. (This does not include low-dose aspirin for prophylactic anticoagulation and routine perioperative anti-inflammatory drugs).
Has a history of a prior failed or delayed fusion at the proposed arthroplasty level.
Since 1955 there have been several accounts of a variety of implants which were the harbinger of the modern day cervical arthroplasty. Initial reports of disc replacements ranged from methylmethacrylate injections to unconstrained spheres composed of various substances ranging from silicone, rubber, and stainless steel [18, 19, 20]. Early arthroplasty designs never achieved much in the form of widespread practical application as they were forsaken after sparse clinical use. However, early success with lumbar disc replacements ushered in a new era of spinal arthroplasty in the cervical spine. In 1991 the Bristol/Cummins disc is credited as the first of the modern articulating Cervical Artificial Disc Replacement (C-ADR) devices which was implanted in 20 patients and was reported to be functional in several for as long as 12 years postoperatively [21]. Since then an array of designs have flooded the marketplace with materials ranging from metal-on-metal, metal-on-plastic, non-articulating metal bonded to plastic, plastic embedded in cloth, polymer fibers wound around a polycarbonate urethane core, and PEEK on PEEK [17, 22, 23, 24]. Despite a wide array of designs and formulations, manufacturers have been unable to emulate and reproduce the mechanical and load bearing properties of the innate human disc. Therefore the various axial and shear loads are still being transferred to the index and neighboring adjacent levels. In order to offset these loads different bearing designs have been conceived, each of which vary based on the amount of impedance, restraint and stability they confer to the spinal unit and dorsal facet joints. Implants without any mechanical impedance built in are considered unconstrained and allow for significant mobility while sacrificing some implant stability. Constrained devices impede movement of the spinal unit within the range of normal physiologic motion and infer greater implant stability by removing shear forces on the facet joints, but in turn place significant stress on the surfaces at the vertebral endplate-implant junction. Semiconstrained implants allow motion just outside the physiologic norm in effort to theoretically decrease the mechanical stresses felt at both at the facet joints and the interface between the implant and the bony surfaces. While often successful, these varied designs have also brought with them a concomitant range of complications with documented occurrences of extrusions, heterotopic ossification, osteolysis, and hardware failure [16, 23, 25, 26, 27, 28].
\nFollowing implantation of the disc replacement a successful cervical hybrid arthroplasty is conditional upon a solid foundation in the form of the adjacent fusion. Fusion implants can be grouped into stand alone versus standard plate and interbody cage designs. Often Allograft, Carbon fiber, Polyetheretherketone (PEEK), and titanium (Ti) have been designated for interbody cage designs. Each material varies in regards to their unique biocompatibility, surface topography, osseointegration, and imaging characteristics. Some implant manufacturers are also borrowing traits from other designs in efforts to improve upon attributes they lack. For example some designers are taking the once inert PEEK cage and bio-actively coating them with either Hydroxyapatite (HA) or Ti, creating a composite design in efforts to improve osseous integration.
\nThe cervical hybrid arthroplasty provides the unique opportunity where with one procedure the surgeon can address an area of junctional kyphosis while simultaneously preserving motion at a neighboring disc. When considering all scenarios for a cervical hybrid surgery, there should be a consistent rationale in regards to which level to fuse and in which level to place the arthroplasty.
\nFor the most part there are some straightforward scenarios which dictate which level warrants the cervical fusion implant. If one disc is entirely collapsed, demonstrates significant bony spurs, and/or heterotopic ossification, this level would assuredly justify the fusion implant. If the operative level lies within the inferior aspect of the spine (i.e. Cervical 6–7, C7-T1) sufficient reasoning exists towards the insertion of a fusion spacer at this level as opposed to an arthroplasty. This is because along the inferior limb of the cervical spine, the sub adjacent interspace levels are morphologically larger and well documented as demonstrating less motion [29, 30, 31]. Their size and innate stiffness coupled with the stability conferred by their adjoining anatomy makes these levels are ideally suited towards forming the foundation of the hybrid construct and bearing any subsequent transferred loads [31, 32, 33]. By contrast, the interspaces along the more cephalad aspect of the spine (Cervical 2–3, Cervical 3–4) routinely comprise a smaller footprint and consequently can only accommodate a smaller implant. As a result these smaller interspaces are often ideally suited towards fusion spacers which tend to come in more sizes and options. Furthermore if there is any indication of ongoing myelopathy or an underlying contiguous myelomalacia, this level would best be served with a fusion implant which would provide a stable postoperative environment. Otherwise in patients who have myelopathy only those without instability and symptoms due to soft disc herniations with or without minor spurs would be good candidates for an arthroplasty.
\nThe core principle behind all arthroplasties is their perceived objective, once implanted, towards minimizing the biomechanical stresses placed on adjacent levels. With this in mind deciding which level should obtain the arthroplasty device is of paramount importance. As a rule of thumb, all efforts are geared towards placing the arthroplasty at the top of the overall construct in order to minimize stress at the superior neighboring and often more mobile disc [29, 34]. When this is not possible, in a circumstance where there are three disc herniations and the decision has been made only to operate on two of the discs because they are the only symptomatic levels, then the arthroplasty should be placed at the level nearest the third disc in hopes of preventing it from further deterioration. Studies have shown that the arthroplasty implant would limit transmission of angular, horizontal, and translation forces experienced by the adjacent third level disc [35, 36, 37, 38, 39, 40].
\nThe sequence of implantation should be considered well in advance during the preoperative planning phase in order to limit complications. During insertion, tapping of the implants with the mallet can lead to an aggravation of an underlying stenotic area, or the migration and loosening of a previously inserted prosthesis [41, 42]. In order to avoid this for all cervical hybrid arthroplasty procedures a thorough decompression of all the intended disc spaces should be performed prior to any implant insertion, with priority given to the most stenotic level. In all circumstances the C-ADR should be implanted prior to the ACDF portion of the procedure. If implanting more than one arthroplasty, all trialing, rasping, drilling for both prostheses should be performed prior to C-ADR implantation [41, 43].
\nPatients commonly notice posterior neck pain following disc arthroplasty. The pain can be a result of surgical positioning, intraoperative distraction on the facet joints and capsules, or an indirect distraction on the endplates from the implant itself. Often these implants are inserted with a considerable amount of force so in order to limit the unsupported transfer of these forces to the paraspinal musculature and facet joints, a properly contoured support should be placed along the posterior aspect of the neck. Figure 2a.
\n(a) The cervical spine is supported here with a foam cushioned pillow, often used by the anesthesiologists when placing the patients in a prone position. In this case the foam cushion supports the neck by acting as a counter force to any horizontal translational or shear forces at play during final implant tapping and placement. Here a cervical bite block is used and a 10 lb. weight allows for axial traction through a neck holster. During surgery this same neck holster can be pulled by the anesthesiologist to allow indirect distraction of the interspace and therefore ease placement of the prosthesis and fusion spacers intraoperatively. The C-arm, pictured here, is left in the lateral position for the majority of the case. (b) Coincidentally the cushion also provides a stable surface where needles can be placed to confirm the length of the surgical incision for a longitudinal skin incision preoperatively.
The cervical hybrid arthroplasty is performed in the supine position under general anesthesia. A transverse incision in line with the planned arthroplasty level is employed for two- or three- level hybrid procedures Figure 2a. Alternatively a longitudinal incision can be used for a more extensive procedure such as a multilevel procedure requiring corpectomies at the fusion level. Implantation of the arthroplasty always demands optimal visualization and therefore the incision should be inline with the proposed arthroplasty interspace while taking into consideration both the trajectory needed and the requisite instrumentation Figure 2b. With that in mind following the skin incision, a standard Anterior Smith Robinson approach provides sufficient access to whichever interspace the surgeon plans to address first. After complete discectomy the endplates are denuded of all cartilaginous tissue with curettage prior to removal of any posterior uncinates or bone spurs. Prior to its removal the posterior longitudinal ligament is inspected for any tears or defects, which may give rise to sequestered fragments causing impingement on the thecal sac or neuroforamina. Once the discectomy has been performed care should be taken to remove any anterior or posterior osteophytes in order to contour the interspace inline with the proposed implant, and in doing so ensure a secure fit.
\nThe width and depth of the intended arthroplasty can be assessed prior to even selecting a trial with the placement of an intraoperative ruler. Figure 3a
(a) A standard ruler is cut to 16 mm and this ruler can then be placed within the interspace to evaluate the depth of the trial, and therefore implant needed. (b) This ruler can then be placed within the interspace to evaluate the width of the trial, and therefore implant needed.
During a cervical hybrid arthroplasty the C-ADR implant should routinely be placed first so no adjacent plate or hardware obstructs any anatomic or fluoroscopic visualization. In order to secure proper midline positioning during intraoperative placement some arthroplasty implants have instrumentation designed to help verify the ideal location. This is important because minimizing prosthetic deviation to within 1.2 mm of the ideal center midline position, has been shown to ensure no detrimental clinical outcomes or long term repercussions [44]. In order to secure proper midline positioning first a collinear Anterior Posterior (AP) fluoroscopic view must be secured in line with the intended interspace (Figure 4). Once an appropriate image has been obtained, accurate midline positioning of the prosthesis can be confirmed (Figure 5a-c). In order to confirm proper midline positioning attention should be made towards discrete morphological and anatomical landmarks. First with visual inspection, confirming equidistant placement of the trial in regards to the longus coli. On fluoroscopy the spinous processes should lie en face and midline with respect to their corresponding vertebral bodies. The edges of the trial should lie equidistant with respect to each of the ascending bilateral uncinate joints. Final midline placement can be confirmed with fluoroscopic visualization. Figure 5a.
\nFerguson view is an AP view of the cervical disc space taken with opening of collimation and caudal tilt angulation of the x-ray tube 30° to 35°.
(a) Proper midline positioning of the prosthesis can be confirmed fluoroscopically with placement of a nerve hook within the instrumentation until a center center “field goal” view is obtained. The nerve hook is clearly bisecting the flanges of the trial. Drilling in this orientation will lock in an appropriately midline positioned implant. (b) Improper midline placement: Here the nerve hook is no longer bisecting the flanges of the implant which confirms the implant is malrotated towards the right, the retractor needs to be loosened and repositioned so that the trial can be repositioned accordingly. (c) Improper midline placement: Here the nerve hook is no longer bisecting the flanges of the implant which confirms the implant is malrotated towards the left and needs to be repositioned accordingly.
Most implant trials come with a drill, chisel, or similar device used to cut grooves in the vertebral body for insertion of the final implant. In order to confirm final implant placement the final imaging obtained while trialing can be compared with the spinal implant to confirm final and accurate positioning
(a) Prior to removal of the trial, discrete measurements can be taken to confirm the exact depth of the insertion of the drill bit. Measurements are obtained from the tip of the drill to the posterior margin of each vertebral body. (b) This depth can then be compared to the implant positioning as tapping occurs to confirm final placement of the arthroplasty. Measurements are obtained from the tip of the implant to the posterior margin of each vertebral body. (c) A final xray and measurements can be obtained to ensure the final implant has not moved after removal of the instrumentation. This will help confirm if any final tamping needs to be performed.
After midline confirmation under fluoroscopy of the arthroplasty attention should be made towards sealing any exposed cancellous surfaces with bone wax in order to prevent heterotopic ossification. Next retractors can be repositioned at the adjacent level for placement of the fusion implant in standard fashion. If using a plate attention should be paid towards the proximity of the plate in regards to the adjacent disc space as this has be found to be the critical determinant of adjacent level heterotopic ossification. [45, 46]
\n51 year old female who presents with cervical pains which she describes as 80% neck pain and 20% arm/shoulder pain, which is 100% left-sided in a C6 and C7 distribution. MRI of the cervical spine demonstrated a C5-C6 3 mm disc herniation with facet arthropathy and severe bilateral foraminal stenosis Figure 7a,b. At C6-C7 a 2 mm left paracentral disc protrusion was noted with severe bilateral foraminal stenosis Figure 7c. For her pain, the patient had tried a prolonged course of conservative management in the form of physical therapy, heating pads, and ice packs. She had tried medications in the form of NSAID’s, muscle relaxants and narcotics. She had consulted with pain management and undergone injection procedures in the form of transforaminal epidural injections at C56 and later at C67, which each provided one hundred percent pain relief and lasted for one month. Patient underwent an uncomplicated Artificial Disc Replacement at C56 and Anterior Cervical Discectomy and Fusion at C67, and has since noted complete resolution of her symptoms Figure 7d
(a) Sagittal MRI of the cervical spine demonstrated a C5-C6 and C67 disc herniations. (b) Axial MRI of the cervical spine demonstrated a C5-C6 bilobed herniation with severe bilateral foraminal stenosis. (c) At C6-C7 a 2 mm disc protrusion was noted with severe bilateral foraminal stenosis. (d) AP Xray artificial disc replacement at C56 and anterior cervical discectomy and fusion at C67. (e) Lateral Xray artificial disc replacement at C56 and anterior cervical discectomy and fusion at C67.
48 year-old female who presented with 95% neck pain and 5% shoulder pain, which is 50% right-sided and 50% left, sided in a C5, C6, and C7 distribution. MRI of the cervical spine demonstrated at the C4-C5 level moderate central spinal canal stenosis, a 4 mm disc protrusion with moderate-to-severe neural foraminal, narrowing bilaterally and impingement on the exiting nerve roots bilaterally Figure 8a-c. At the C5-C6, level, there was a 4 mm left paracentral disc protrusion with severe neural foraminal narrowing on the left and moderate foraminal narrowing on the right. There is impingement on the exiting nerve roots bilaterally greater on the left than the right Figure 8d. At the C6-C7 level, there was a 5 mm right paracentral disc protrusion with severe neural foraminal narrowing on the right with impingement on the exiting nerve roots on the right Figure 8e. There is moderate neural foraminal narrowing on the left and moderate central spinal canal stenosis. For her pain, the patient had tried a prolonged course of conservative management in the form of physical therapy, chiropractic treatment, heating pads, and ice packs. She had tried medications in the form of NSAID’s, muscle relaxants and narcotics. She had consulted with pain management and undergone three injection procedures in the form of transforaminal epidural injections at C45, C56 and later at C67, each of which provided seventy percent pain relief and lasted for one to three months. Patient underwent an uncomplicated Artificial Disc Replacement at C56 and Anterior Cervical Discectomy and Fusion at C45 and C67, and has since noted resolution of her symptoms Figure 8f
(a, b) Sagittal MRI of the cervical spine demonstrated herniations at the C4-C5, C56, C67. (c) Axial MRI of the cervical spine demonstrated C45 large disc herniation with neuroforaminal stenosis. (d) Axial MRI of the cervical spine demonstrated 56 eccentric disc herniations with left sided neuroforaminal stenosis. (e) Axial MRI of the cervical spine demonstrated C67 eccentric disc herniation with right sided neuroforaminal stenosis. (f) AP Xray artificial disc replacement at C56 and anterior cervical discectomy and fusion at C45, and C67. (g) LATERAL Xray artificial disc replacement at C56 and anterior cervical discectomy and fusion at C45, and C67.
In properly indicated patients, with meticulous preoperative planning and sound surgical technique, cervical hybrid arthroplasty offers an excellent surgical option and is a safe and effective alternative to multilevel fusion for the management of cervical radiculopathy and myelopathy.
\n“The authors declare no conflict of interest.”
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\n\nOver the years we have learned what is important. What makes a difference to the researchers that work with us, what they value. Something that is very high not only on their lists, but our own, is the quality of the published content.
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\n\nYOUR WORK, YOUR COPYRIGHT
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After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. 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Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Bacterial Infectious Diseases",value:3,count:2},{group:"subseries",caption:"Parasitic Infectious Diseases",value:5,count:4},{group:"subseries",caption:"Viral Infectious Diseases",value:6,count:7}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:2},{group:"publicationYear",caption:"2021",value:2021,count:4},{group:"publicationYear",caption:"2020",value:2020,count:3},{group:"publicationYear",caption:"2019",value:2019,count:3},{group:"publicationYear",caption:"2018",value:2018,count:1}],authors:{paginationCount:250,paginationItems:[{id:"274452",title:"Dr.",name:"Yousif",middleName:"Mohamed",surname:"Abdallah",slug:"yousif-abdallah",fullName:"Yousif Abdallah",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/274452/images/8324_n.jpg",biography:"I certainly enjoyed my experience in Radiotherapy and Nuclear Medicine, particularly it has been in different institutions and hospitals with different Medical Cultures and allocated resources. Radiotherapy and Nuclear Medicine Technology has always been my aspiration and my life. As years passed I accumulated a tremendous amount of skills and knowledge in Radiotherapy and Nuclear Medicine, Conventional Radiology, Radiation Protection, Bioinformatics Technology, PACS, Image processing, clinically and lecturing that will enable me to provide a valuable service to the community as a Researcher and Consultant in this field. My method of translating this into day to day in clinical practice is non-exhaustible and my habit of exchanging knowledge and expertise with others in those fields is the code and secret of success.",institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"313277",title:"Dr.",name:"Bartłomiej",middleName:null,surname:"Płaczek",slug:"bartlomiej-placzek",fullName:"Bartłomiej Płaczek",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/313277/images/system/313277.jpg",biography:"Bartłomiej Płaczek, MSc (2002), Ph.D. (2005), Habilitation (2016), is a professor at the University of Silesia, Institute of Computer Science, Poland, and an expert from the National Centre for Research and Development. His research interests include sensor networks, smart sensors, intelligent systems, and image processing with applications in healthcare and medicine. He is the author or co-author of more than seventy papers in peer-reviewed journals and conferences as well as the co-author of several books. He serves as a reviewer for many scientific journals, international conferences, and research foundations. Since 2010, Dr. Placzek has been a reviewer of grants and projects (including EU projects) in the field of information technologies.",institutionString:"University of Silesia",institution:{name:"University of Silesia",country:{name:"Poland"}}},{id:"35000",title:"Prof.",name:"Ulrich H.P",middleName:"H.P.",surname:"Fischer",slug:"ulrich-h.p-fischer",fullName:"Ulrich H.P Fischer",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/35000/images/3052_n.jpg",biography:"Academic and Professional Background\nUlrich H. P. has Diploma and PhD degrees in Physics from the Free University Berlin, Germany. He has been working on research positions in the Heinrich-Hertz-Institute in Germany. Several international research projects has been performed with European partners from France, Netherlands, Norway and the UK. He is currently Professor of Communications Systems at the Harz University of Applied Sciences, Germany.\n\nPublications and Publishing\nHe has edited one book, a special interest book about ‘Optoelectronic Packaging’ (VDE, Berlin, Germany), and has published over 100 papers and is owner of several international patents for WDM over POF key elements.\n\nKey Research and Consulting Interests\nUlrich’s research activity has always been related to Spectroscopy and Optical Communications Technology. Specific current interests include the validation of complex instruments, and the application of VR technology to the development and testing of measurement systems. He has been reviewer for several publications of the Optical Society of America\\'s including Photonics Technology Letters and Applied Optics.\n\nPersonal Interests\nThese include motor cycling in a very relaxed manner and performing martial arts.",institutionString:null,institution:{name:"Charité",country:{name:"Germany"}}},{id:"341622",title:"Ph.D.",name:"Eduardo",middleName:null,surname:"Rojas Alvarez",slug:"eduardo-rojas-alvarez",fullName:"Eduardo Rojas Alvarez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/341622/images/15892_n.jpg",biography:null,institutionString:null,institution:{name:"University of Cuenca",country:{name:"Ecuador"}}},{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/215610/images/system/215610.jpeg",biography:"Muhammad Sarfraz is a professor in the Department of Information Science, Kuwait University. His research interests include computer graphics, computer vision, image processing, machine learning, pattern recognition, soft computing, data science, intelligent systems, information technology, and information systems. Prof. Sarfraz has been a keynote/invited speaker on various platforms around the globe. He has advised various students for their MSc and Ph.D. theses. He has published more than 400 publications as books, journal articles, and conference papers. He is a member of various professional societies and a chair and member of the International Advisory Committees and Organizing Committees of various international conferences. Prof. Sarfraz is also an editor-in-chief and editor of various international journals.",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"32650",title:"Prof.",name:"Lukas",middleName:"Willem",surname:"Snyman",slug:"lukas-snyman",fullName:"Lukas Snyman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/32650/images/4136_n.jpg",biography:"Lukas Willem Snyman received his basic education at primary and high schools in South Africa, Eastern Cape. He enrolled at today's Nelson Metropolitan University and graduated from this university with a BSc in Physics and Mathematics, B.Sc Honors in Physics, MSc in Semiconductor Physics, and a Ph.D. in Semiconductor Physics in 1987. After his studies, he chose an academic career and devoted his energy to the teaching of physics to first, second, and third-year students. After positions as a lecturer at the University of Port Elizabeth, he accepted a position as Associate Professor at the University of Pretoria, South Africa.\r\n\r\nIn 1992, he motivates the concept of 'television and computer-based education” as means to reach large student numbers with only the best of teaching expertise and publishes an article on the concept in the SA Journal of Higher Education of 1993 (and later in 2003). The University of Pretoria subsequently approved a series of test projects on the concept with outreach to Mamelodi and Eerste Rust in 1993. In 1994, the University established a 'Unit for Telematic Education ' as a support section for multiple faculties at the University of Pretoria. In subsequent years, the concept of 'telematic education” subsequently becomes well established in academic circles in South Africa, grew in popularity, and is adopted by many universities and colleges throughout South Africa as a medium of enhancing education and training, as a method to reaching out to far out communities, and as a means to enhance study from the home environment.\r\n\r\nProfessor Snyman in subsequent years pursued research in semiconductor physics, semiconductor devices, microelectronics, and optoelectronics.\r\n\r\nIn 2000 he joined the TUT as a full professor. Here served for a period as head of the Department of Electronic Engineering. Here he makes contributions to solar energy development, microwave and optoelectronic device development, silicon photonics, as well as contributions to new mobile telecommunication systems and network planning in SA.\r\n\r\nCurrently, he teaches electronics and telecommunications at the TUT to audiences ranging from first-year students to Ph.D. level.\r\n\r\nFor his research in the field of 'Silicon Photonics” since 1990, he has published (as author and co-author) about thirty internationally reviewed articles in scientific journals, contributed to more than forty international conferences, about 25 South African provisional patents (as inventor and co-inventor), 8 PCT international patent applications until now. Of these, two USA patents applications, two European Patents, two Korean patents, and ten SA patents have been granted. A further 4 USA patents, 5 European patents, 3 Korean patents, 3 Chinese patents, and 3 Japanese patents are currently under consideration.\r\n\r\nRecently he has also published an extensive scholarly chapter in an internet open access book on 'Integrating Microphotonic Systems and MOEMS into standard Silicon CMOS Integrated circuitry”.\r\n\r\nFurthermore, Professor Snyman recently steered a new initiative at the TUT by introducing a 'Laboratory for Innovative Electronic Systems ' at the Department of Electrical Engineering. The model of this laboratory or center is to primarily combine outputs as achieved by high-level research with lower-level system development and entrepreneurship in a technical university environment. Students are allocated to projects at different levels with PhDs and Master students allocated to the generation of new knowledge and new technologies, while students at the diploma and Baccalaureus level are allocated to electronic systems development with a direct and a near application for application in industry or the commercial and public sectors in South Africa.\r\n\r\nProfessor Snyman received the WIRSAM Award of 1983 and the WIRSAM Award in 1985 in South Africa for best research papers by a young scientist at two international conferences on electron microscopy in South Africa. He subsequently received the SA Microelectronics Award for the best dissertation emanating from studies executed at a South African university in the field of Physics and Microelectronics in South Africa in 1987. In October of 2011, Professor Snyman received the prestigious Institutional Award for 'Innovator of the Year” for 2010 at the Tshwane University of Technology, South Africa. This award was based on the number of patents recognized and granted by local and international institutions as well as for his contributions concerning innovation at the TUT.",institutionString:null,institution:{name:"University of South Africa",country:{name:"South Africa"}}},{id:"317279",title:"Mr.",name:"Ali",middleName:"Usama",surname:"Syed",slug:"ali-syed",fullName:"Ali Syed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/317279/images/16024_n.png",biography:"A creative, talented, and innovative young professional who is dedicated, well organized, and capable research fellow with two years of experience in graduate-level research, published in engineering journals and book, with related expertise in Bio-robotics, equally passionate about the aesthetics of the mechanical and electronic system, obtained expertise in the use of MS Office, MATLAB, SolidWorks, LabVIEW, Proteus, Fusion 360, having a grasp on python, C++ and assembly language, possess proven ability in acquiring research grants, previous appointments with social and educational societies with experience in administration, current affiliations with IEEE and Web of Science, a confident presenter at conferences and teacher in classrooms, able to explain complex information to audiences of all levels.",institutionString:null,institution:{name:"Air University",country:{name:"Pakistan"}}},{id:"75526",title:"Ph.D.",name:"Zihni Onur",middleName:null,surname:"Uygun",slug:"zihni-onur-uygun",fullName:"Zihni Onur Uygun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/75526/images/12_n.jpg",biography:"My undergraduate education and my Master of Science educations at Ege University and at Çanakkale Onsekiz Mart University have given me a firm foundation in Biochemistry, Analytical Chemistry, Biosensors, Bioelectronics, Physical Chemistry and Medicine. After obtaining my degree as a MSc in analytical chemistry, I started working as a research assistant in Ege University Medical Faculty in 2014. In parallel, I enrolled to the MSc program at the Department of Medical Biochemistry at Ege University to gain deeper knowledge on medical and biochemical sciences as well as clinical chemistry in 2014. In my PhD I deeply researched on biosensors and bioelectronics and finished in 2020. Now I have eleven SCI-Expanded Index published papers, 6 international book chapters, referee assignments for different SCIE journals, one international patent pending, several international awards, projects and bursaries. In parallel to my research assistant position at Ege University Medical Faculty, Department of Medical Biochemistry, in April 2016, I also founded a Start-Up Company (Denosens Biotechnology LTD) by the support of The Scientific and Technological Research Council of Turkey. Currently, I am also working as a CEO in Denosens Biotechnology. The main purposes of the company, which carries out R&D as a research center, are to develop new generation biosensors and sensors for both point-of-care diagnostics; such as glucose, lactate, cholesterol and cancer biomarker detections. My specific experimental and instrumental skills are Biochemistry, Biosensor, Analytical Chemistry, Electrochemistry, Mobile phone based point-of-care diagnostic device, POCTs and Patient interface designs, HPLC, Tandem Mass Spectrometry, Spectrophotometry, ELISA.",institutionString:null,institution:{name:"Ege University",country:{name:"Turkey"}}},{id:"267434",title:"Dr.",name:"Rohit",middleName:null,surname:"Raja",slug:"rohit-raja",fullName:"Rohit Raja",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/267434/images/system/267434.jpg",biography:"Dr. Rohit Raja received Ph.D. in Computer Science and Engineering from Dr. CVRAMAN University in 2016. His main research interest includes Face recognition and Identification, Digital Image Processing, Signal Processing, and Networking. Presently he is working as Associate Professor in IT Department, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur (CG), India. He has authored several Journal and Conference Papers. He has good Academics & Research experience in various areas of CSE and IT. He has filed and successfully published 27 Patents. He has received many time invitations to be a Guest at IEEE Conferences. He has published 100 research papers in various International/National Journals (including IEEE, Springer, etc.) and Proceedings of the reputed International/ National Conferences (including Springer and IEEE). He has been nominated to the board of editors/reviewers of many peer-reviewed and refereed Journals (including IEEE, Springer).",institutionString:"Guru Ghasidas Vishwavidyalaya",institution:{name:"Guru Ghasidas Vishwavidyalaya",country:{name:"India"}}},{id:"246502",title:"Dr.",name:"Jaya T.",middleName:"T",surname:"Varkey",slug:"jaya-t.-varkey",fullName:"Jaya T. Varkey",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246502/images/11160_n.jpg",biography:"Jaya T. Varkey, PhD, graduated with a degree in Chemistry from Cochin University of Science and Technology, Kerala, India. She obtained a PhD in Chemistry from the School of Chemical Sciences, Mahatma Gandhi University, Kerala, India, and completed a post-doctoral fellowship at the University of Minnesota, USA. She is a research guide at Mahatma Gandhi University and Associate Professor in Chemistry, St. Teresa’s College, Kochi, Kerala, India.\nDr. Varkey received a National Young Scientist award from the Indian Science Congress (1995), a UGC Research award (2016–2018), an Indian National Science Academy (INSA) Visiting Scientist award (2018–2019), and a Best Innovative Faculty award from the All India Association for Christian Higher Education (AIACHE) (2019). She Hashas received the Sr. Mary Cecil prize for best research paper three times. She was also awarded a start-up to develop a tea bag water filter. \nDr. Varkey has published two international books and twenty-seven international journal publications. She is an editorial board member for five international journals.",institutionString:"St. Teresa’s College",institution:null},{id:"250668",title:"Dr.",name:"Ali",middleName:null,surname:"Nabipour Chakoli",slug:"ali-nabipour-chakoli",fullName:"Ali Nabipour Chakoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/250668/images/system/250668.jpg",biography:"Academic Qualification:\r\n•\tPhD in Materials Physics and Chemistry, From: Sep. 2006, to: Sep. 2010, School of Materials Science and Engineering, Harbin Institute of Technology, Thesis: Structure and Shape Memory Effect of Functionalized MWCNTs/poly (L-lactide-co-ε-caprolactone) Nanocomposites. Supervisor: Prof. Wei Cai,\r\n•\tM.Sc in Applied Physics, From: 1996, to: 1998, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Determination of Boron in Micro alloy Steels with solid state nuclear track detectors by neutron induced auto radiography, Supervisors: Dr. M. Hosseini Ashrafi and Dr. A. Hosseini.\r\n•\tB.Sc. in Applied Physics, From: 1991, to: 1996, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Design of shielding for Am-Be neutron sources for In Vivo neutron activation analysis, Supervisor: Dr. M. Hosseini Ashrafi.\r\n\r\nResearch Experiences:\r\n1.\tNanomaterials, Carbon Nanotubes, Graphene: Synthesis, Functionalization and Characterization,\r\n2.\tMWCNTs/Polymer Composites: Fabrication and Characterization, \r\n3.\tShape Memory Polymers, Biodegradable Polymers, ORC, Collagen,\r\n4.\tMaterials Analysis and Characterizations: TEM, SEM, XPS, FT-IR, Raman, DSC, DMA, TGA, XRD, GPC, Fluoroscopy, \r\n5.\tInteraction of Radiation with Mater, Nuclear Safety and Security, NDT(RT),\r\n6.\tRadiation Detectors, Calibration (SSDL),\r\n7.\tCompleted IAEA e-learning Courses:\r\nNuclear Security (15 Modules),\r\nNuclear Safety:\r\nTSA 2: Regulatory Protection in Occupational Exposure,\r\nTips & Tricks: Radiation Protection in Radiography,\r\nSafety and Quality in Radiotherapy,\r\nCourse on Sealed Radioactive Sources,\r\nCourse on Fundamentals of Environmental Remediation,\r\nCourse on Planning for Environmental Remediation,\r\nKnowledge Management Orientation Course,\r\nFood Irradiation - Technology, Applications and Good Practices,\r\nEmployment:\r\nFrom 2010 to now: Academic staff, Nuclear Science and Technology Research Institute, Kargar Shomali, Tehran, Iran, P.O. Box: 14395-836.\r\nFrom 1997 to 2006: Expert of Materials Analysis and Characterization. Research Center of Agriculture and Medicine. Rajaeeshahr, Karaj, Iran, P. O. Box: 31585-498.",institutionString:"Atomic Energy Organization of Iran",institution:{name:"Atomic Energy Organization of Iran",country:{name:"Iran"}}},{id:"248279",title:"Dr.",name:"Monika",middleName:"Elzbieta",surname:"Machoy",slug:"monika-machoy",fullName:"Monika Machoy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248279/images/system/248279.jpeg",biography:"Monika Elżbieta Machoy, MD, graduated with distinction from the Faculty of Medicine and Dentistry at the Pomeranian Medical University in 2009, defended her PhD thesis with summa cum laude in 2016 and is currently employed as a researcher at the Department of Orthodontics of the Pomeranian Medical University. She expanded her professional knowledge during a one-year scholarship program at the Ernst Moritz Arndt University in Greifswald, Germany and during a three-year internship at the Technical University in Dresden, Germany. She has been a speaker at numerous orthodontic conferences, among others, American Association of Orthodontics, European Orthodontic Symposium and numerous conferences of the Polish Orthodontic Society. She conducts research focusing on the effect of orthodontic treatment on dental and periodontal tissues and the causes of pain in orthodontic patients.",institutionString:"Pomeranian Medical University",institution:{name:"Pomeranian Medical University",country:{name:"Poland"}}},{id:"252743",title:"Prof.",name:"Aswini",middleName:"Kumar",surname:"Kar",slug:"aswini-kar",fullName:"Aswini Kar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252743/images/10381_n.jpg",biography:"uploaded in cv",institutionString:null,institution:{name:"KIIT University",country:{name:"India"}}},{id:"204256",title:"Dr.",name:"Anil",middleName:"Kumar",surname:"Kumar Sahu",slug:"anil-kumar-sahu",fullName:"Anil Kumar Sahu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204256/images/14201_n.jpg",biography:"I have nearly 11 years of research and teaching experience. I have done my master degree from University Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur, Chhattisgarh India. I have published 16 review and research articles in international and national journals and published 4 chapters in IntechOpen, the world’s leading publisher of Open access books. I have presented many papers at national and international conferences. I have received research award from Indian Drug Manufacturers Association in year 2015. My research interest extends from novel lymphatic drug delivery systems, oral delivery system for herbal bioactive to formulation optimization.",institutionString:null,institution:{name:"Chhattisgarh Swami Vivekanand Technical University",country:{name:"India"}}},{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",biography:"An assistant professor at Department of Biomedical Computer Systems, at Institute of Computer Science, Silesian University in Katowice. Scientific interests: computer analysis and processing of images, biomedical images, databases and programming languages. He is an author and co-author of scientific publications covering analysis and processing of biomedical images and development of database systems.",institutionString:"University of Silesia",institution:null},{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",biography:"Dr. Hadi Mohammadi is a biomedical engineer with hands-on experience in the design and development of many engineering structures and medical devices through various projects that he has been involved in over the past twenty years. Dr. Mohammadi received his BSc. and MSc. degrees in Mechanical Engineering from Sharif University of Technology, Tehran, Iran, and his PhD. degree in Biomedical Engineering (biomaterials) from the University of Western Ontario. He was a postdoctoral trainee for almost four years at University of Calgary and Harvard Medical School. He is an industry innovator having created the technology to produce lifelike synthetic platforms that can be used for the simulation of almost all cardiovascular reconstructive surgeries. He’s been heavily involved in the design and development of cardiovascular devices and technology for the past 10 years. He is currently an Assistant Professor with the University of British Colombia, Canada.",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",country:{name:"Canada"}}},{id:"254463",title:"Prof.",name:"Haisheng",middleName:null,surname:"Yang",slug:"haisheng-yang",fullName:"Haisheng Yang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/254463/images/system/254463.jpeg",biography:"Haisheng Yang, Ph.D., Professor and Director of the Department of Biomedical Engineering, College of Life Science and Bioengineering, Beijing University of Technology. He received his Ph.D. degree in Mechanics/Biomechanics from Harbin Institute of Technology (jointly with University of California, Berkeley). Afterwards, he worked as a Postdoctoral Research Associate in the Purdue Musculoskeletal Biology and Mechanics Lab at the Department of Basic Medical Sciences, Purdue University, USA. He also conducted research in the Research Centre of Shriners Hospitals for Children-Canada at McGill University, Canada. Dr. Yang has over 10 years research experience in orthopaedic biomechanics and mechanobiology of bone adaptation and regeneration. He earned an award from Beijing Overseas Talents Aggregation program in 2017 and serves as Beijing Distinguished Professor.",institutionString:null,institution:{name:"Beijing University of Technology",country:{name:"China"}}},{id:"89721",title:"Dr.",name:"Mehmet",middleName:"Cuneyt",surname:"Ozmen",slug:"mehmet-ozmen",fullName:"Mehmet Ozmen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/89721/images/7289_n.jpg",biography:null,institutionString:null,institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"242893",title:"Ph.D. Student",name:"Joaquim",middleName:null,surname:"De Moura",slug:"joaquim-de-moura",fullName:"Joaquim De Moura",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/242893/images/7133_n.jpg",biography:"Joaquim de Moura received his degree in Computer Engineering in 2014 from the University of A Coruña (Spain). In 2016, he received his M.Sc degree in Computer Engineering from the same university. He is currently pursuing his Ph.D degree in Computer Science in a collaborative project between ophthalmology centers in Galicia and the University of A Coruña. His research interests include computer vision, machine learning algorithms and analysis and medical imaging processing of various kinds.",institutionString:null,institution:{name:"University of A Coruña",country:{name:"Spain"}}},{id:"294334",title:"B.Sc.",name:"Marc",middleName:null,surname:"Bruggeman",slug:"marc-bruggeman",fullName:"Marc Bruggeman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/294334/images/8242_n.jpg",biography:"Chemical engineer graduate, with a passion for material science and specific interest in polymers - their near infinite applications intrigue me. \n\nI plan to continue my scientific career in the field of polymeric biomaterials as I am fascinated by intelligent, bioactive and biomimetic materials for use in both consumer and medical applications.",institutionString:null,institution:null},{id:"255757",title:"Dr.",name:"Igor",middleName:"Victorovich",surname:"Lakhno",slug:"igor-lakhno",fullName:"Igor Lakhno",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255757/images/system/255757.jpg",biography:"Igor Victorovich Lakhno was born in 1971 in Kharkiv (Ukraine). \nMD – 1994, Kharkiv National Medical Univesity.\nOb&Gyn; – 1997, master courses in Kharkiv Medical Academy of Postgraduate Education.\nPh.D. – 1999, Kharkiv National Medical Univesity.\nDSC – 2019, PL Shupik National Academy of Postgraduate Education \nProfessor – 2021, Department of Obstetrics and Gynecology of VN Karazin Kharkiv National University\nHead of Department – 2021, Department of Perinatology, Obstetrics and gynecology of Kharkiv Medical Academy of Postgraduate Education\nIgor Lakhno has been graduated from international training courses on reproductive medicine and family planning held at Debrecen University (Hungary) in 1997. Since 1998 Lakhno Igor has worked as an associate professor in the department of obstetrics and gynecology of VN Karazin National University and an associate professor of the perinatology, obstetrics, and gynecology department of Kharkiv Medical Academy of Postgraduate Education. Since June 2019 he’s been a professor in the department of obstetrics and gynecology of VN Karazin National University and a professor of the perinatology, obstetrics, and gynecology department. He’s affiliated with Kharkiv Medical Academy of Postgraduate Education as a Head of Department from November 2021. Igor Lakhno has participated in several international projects on fetal non-invasive electrocardiography (with Dr. J. A. Behar (Technion), Prof. D. Hoyer (Jena University), and José Alejandro Díaz Méndez (National Institute of Astrophysics, Optics, and Electronics, Mexico). He’s an author of about 200 printed works and there are 31 of them in Scopus or Web of Science databases. Igor Lakhno is a member of the Editorial Board of Reproductive Health of Woman, Emergency Medicine, and Technology Transfer Innovative Solutions in Medicine (Estonia). He is a medical Editor of “Z turbotoyu pro zhinku”. Igor Lakhno is a reviewer of the Journal of Obstetrics and Gynaecology (Taylor and Francis), British Journal of Obstetrics and Gynecology (Wiley), Informatics in Medicine Unlocked (Elsevier), The Journal of Obstetrics and Gynecology Research (Wiley), Endocrine, Metabolic & Immune Disorders-Drug Targets (Bentham Open), The Open Biomedical Engineering Journal (Bentham Open), etc. He’s defended a dissertation for a DSc degree “Pre-eclampsia: prediction, prevention, and treatment”. Three years ago Igor Lakhno has participated in a training course on innovative technologies in medical education at Lublin Medical University (Poland). Lakhno Igor has participated as a speaker in several international conferences and congresses (International Conference on Biological Oscillations April 10th-14th 2016, Lancaster, UK, The 9th conference of the European Study Group on Cardiovascular Oscillations). His main scientific interests: are obstetrics, women’s health, fetal medicine, and cardiovascular medicine. \nIgor Lakhno is a consultant at Kharkiv municipal perinatal center. He’s graduated from training courses on endoscopy in gynecology. He has 28 years of practical experience in the field.",institutionString:null,institution:null},{id:"244950",title:"Dr.",name:"Salvatore",middleName:null,surname:"Di Lauro",slug:"salvatore-di-lauro",fullName:"Salvatore Di Lauro",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0030O00002bSF1HQAW/ProfilePicture%202021-12-20%2014%3A54%3A14.482",biography:"Name:\n\tSALVATORE DI LAURO\nAddress:\n\tHospital Clínico Universitario Valladolid\nAvda Ramón y Cajal 3\n47005, Valladolid\nSpain\nPhone number: \nFax\nE-mail:\n\t+34 983420000 ext 292\n+34 983420084\nsadilauro@live.it\nDate and place of Birth:\nID Number\nMedical Licence \nLanguages\t09-05-1985. Villaricca (Italy)\n\nY1281863H\n474707061\nItalian (native language)\nSpanish (read, written, spoken)\nEnglish (read, written, spoken)\nPortuguese (read, spoken)\nFrench (read)\n\t\t\nCurrent position (title and company)\tDate (Year)\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. Private practise.\t2017-today\n\n2019-today\n\t\n\t\nEducation (High school, university and postgraduate training > 3 months)\tDate (Year)\nDegree in Medicine and Surgery. University of Neaples 'Federico II”\nResident in Opthalmology. Hospital Clinico Universitario Valladolid\nMaster in Vitreo-Retina. IOBA. University of Valladolid\nFellow of the European Board of Ophthalmology. Paris\nMaster in Research in Ophthalmology. University of Valladolid\t2003-2009\n2012-2016\n2016-2017\n2016\n2012-2013\n\t\nEmployments (company and positions)\tDate (Year)\nResident in Ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl.\nFellow in Vitreo-Retina. IOBA. University of Valladolid\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. \n\t2012-2016\n2016-2017\n2017-today\n\n2019-Today\n\n\n\t\nClinical Research Experience (tasks and role)\tDate (Year)\nAssociated investigator\n\n' FIS PI20/00740: DESARROLLO DE UNA CALCULADORA DE RIESGO DE\nAPARICION DE RETINOPATIA DIABETICA BASADA EN TECNICAS DE IMAGEN MULTIMODAL EN PACIENTES DIABETICOS TIPO 1. Grant by: Ministerio de Ciencia e Innovacion \n\n' (BIO/VA23/14) Estudio clínico multicéntrico y prospectivo para validar dos\nbiomarcadores ubicados en los genes p53 y MDM2 en la predicción de los resultados funcionales de la cirugía del desprendimiento de retina regmatógeno. Grant by: Gerencia Regional de Salud de la Junta de Castilla y León.\n' Estudio multicéntrico, aleatorizado, con enmascaramiento doble, en 2 grupos\nparalelos y de 52 semanas de duración para comparar la eficacia, seguridad e inmunogenicidad de SOK583A1 respecto a Eylea® en pacientes con degeneración macular neovascular asociada a la edad' (CSOK583A12301; N.EUDRA: 2019-004838-41; FASE III). Grant by Hexal AG\n\n' Estudio de fase III, aleatorizado, doble ciego, con grupos paralelos, multicéntrico para comparar la eficacia y la seguridad de QL1205 frente a Lucentis® en pacientes con degeneración macular neovascular asociada a la edad. (EUDRACT: 2018-004486-13). Grant by Qilu Pharmaceutical Co\n\n' Estudio NEUTON: Ensayo clinico en fase IV para evaluar la eficacia de aflibercept en pacientes Naive con Edema MacUlar secundario a Oclusion de Vena CenTral de la Retina (OVCR) en regimen de tratamientO iNdividualizado Treat and Extend (TAE)”, (2014-000975-21). Grant by Fundacion Retinaplus\n\n' Evaluación de la seguridad y bioactividad de anillos de tensión capsular en conejo. Proyecto Procusens. Grant by AJL, S.A.\n\n'Estudio epidemiológico, prospectivo, multicéntrico y abierto\\npara valorar la frecuencia de la conjuntivitis adenovírica diagnosticada mediante el test AdenoPlus®\\nTest en pacientes enfermos de conjuntivitis aguda”\\n. National, multicenter study. Grant by: NICOX.\n\nEuropean multicentric trial: 'Evaluation of clinical outcomes following the use of Systane Hydration in patients with dry eye”. Study Phase 4. Grant by: Alcon Labs'\n\nVLPs Injection and Activation in a Rabbit Model of Uveal Melanoma. Grant by Aura Bioscience\n\nUpdating and characterization of a rabbit model of uveal melanoma. Grant by Aura Bioscience\n\nEnsayo clínico en fase IV para evaluar las variantes genéticas de la vía del VEGF como biomarcadores de eficacia del tratamiento con aflibercept en pacientes con degeneración macular asociada a la edad (DMAE) neovascular. Estudio BIOIMAGE. IMO-AFLI-2013-01\n\nEstudio In-Eye:Ensayo clínico en fase IV, abierto, aleatorizado, de 2 brazos,\nmulticçentrico y de 12 meses de duración, para evaluar la eficacia y seguridad de un régimen de PRN flexible individualizado de 'esperar y extender' versus un régimen PRN según criterios de estabilización mediante evaluaciones mensuales de inyecciones intravítreas de ranibizumab 0,5 mg en pacientes naive con neovascularización coriodea secunaria a la degeneración macular relacionada con la edad. CP: CRFB002AES03T\n\nTREND: Estudio Fase IIIb multicéntrico, randomizado, de 12 meses de\nseguimiento con evaluador de la agudeza visual enmascarado, para evaluar la eficacia y la seguridad de ranibizumab 0.5mg en un régimen de tratar y extender comparado con un régimen mensual, en pacientes con degeneración macular neovascular asociada a la edad. CP: CRFB002A2411 Código Eudra CT:\n2013-002626-23\n\n\n\nPublications\t\n\n2021\n\n\n\n\n2015\n\n\n\n\n2021\n\n\n\n\n\n2021\n\n\n\n\n2015\n\n\n\n\n2015\n\n\n2014\n\n\n\n\n2015-16\n\n\n\n2015\n\n\n2014\n\n\n2014\n\n\n\n\n2014\n\n\n\n\n\n\n\n2014\n\nJose Carlos Pastor; Jimena Rojas; Salvador Pastor-Idoate; Salvatore Di Lauro; Lucia Gonzalez-Buendia; Santiago Delgado-Tirado. Proliferative vitreoretinopathy: A new concept of disease pathogenesis and practical\nconsequences. Progress in Retinal and Eye Research. 51, pp. 125 - 155. 03/2016. DOI: 10.1016/j.preteyeres.2015.07.005\n\n\nLabrador-Velandia S; Alonso-Alonso ML; Di Lauro S; García-Gutierrez MT; Srivastava GK; Pastor JC; Fernandez-Bueno I. Mesenchymal stem cells provide paracrine neuroprotective resources that delay degeneration of co-cultured organotypic neuroretinal cultures.Experimental Eye Research. 185, 17/05/2019. DOI: 10.1016/j.exer.2019.05.011\n\nSalvatore Di Lauro; Maria Teresa Garcia Gutierrez; Ivan Fernandez Bueno. Quantification of pigment epithelium-derived factor (PEDF) in an ex vivo coculture of retinal pigment epithelium cells and neuroretina.\nJournal of Allbiosolution. 2019. ISSN 2605-3535\n\nSonia Labrador Velandia; Salvatore Di Lauro; Alonso-Alonso ML; Tabera Bartolomé S; Srivastava GK; Pastor JC; Fernandez-Bueno I. Biocompatibility of intravitreal injection of human mesenchymal stem cells in immunocompetent rabbits. Graefe's archive for clinical and experimental ophthalmology. 256 - 1, pp. 125 - 134. 01/2018. DOI: 10.1007/s00417-017-3842-3\n\n\nSalvatore Di Lauro, David Rodriguez-Crespo, Manuel J Gayoso, Maria T Garcia-Gutierrez, J Carlos Pastor, Girish K Srivastava, Ivan Fernandez-Bueno. A novel coculture model of porcine central neuroretina explants and retinal pigment epithelium cells. Molecular Vision. 2016 - 22, pp. 243 - 253. 01/2016.\n\nSalvatore Di Lauro. Classifications for Proliferative Vitreoretinopathy ({PVR}): An Analysis of Their Use in Publications over the Last 15 Years. Journal of Ophthalmology. 2016, pp. 1 - 6. 01/2016. DOI: 10.1155/2016/7807596\n\nSalvatore Di Lauro; Rosa Maria Coco; Rosa Maria Sanabria; Enrique Rodriguez de la Rua; Jose Carlos Pastor. Loss of Visual Acuity after Successful Surgery for Macula-On Rhegmatogenous Retinal Detachment in a Prospective Multicentre Study. Journal of Ophthalmology. 2015:821864, 2015. DOI: 10.1155/2015/821864\n\nIvan Fernandez-Bueno; Salvatore Di Lauro; Ivan Alvarez; Jose Carlos Lopez; Maria Teresa Garcia-Gutierrez; Itziar Fernandez; Eva Larra; Jose Carlos Pastor. Safety and Biocompatibility of a New High-Density Polyethylene-Based\nSpherical Integrated Porous Orbital Implant: An Experimental Study in Rabbits. Journal of Ophthalmology. 2015:904096, 2015. DOI: 10.1155/2015/904096\n\nPastor JC; Pastor-Idoate S; Rodríguez-Hernandez I; Rojas J; Fernandez I; Gonzalez-Buendia L; Di Lauro S; Gonzalez-Sarmiento R. Genetics of PVR and RD. Ophthalmologica. 232 - Suppl 1, pp. 28 - 29. 2014\n\nRodriguez-Crespo D; Di Lauro S; Singh AK; Garcia-Gutierrez MT; Garrosa M; Pastor JC; Fernandez-Bueno I; Srivastava GK. Triple-layered mixed co-culture model of RPE cells with neuroretina for evaluating the neuroprotective effects of adipose-MSCs. Cell Tissue Res. 358 - 3, pp. 705 - 716. 2014.\nDOI: 10.1007/s00441-014-1987-5\n\nCarlo De Werra; Salvatore Condurro; Salvatore Tramontano; Mario Perone; Ivana Donzelli; Salvatore Di Lauro; Massimo Di Giuseppe; Rosa Di Micco; Annalisa Pascariello; Antonio Pastore; Giorgio Diamantis; Giuseppe Galloro. Hydatid disease of the liver: thirty years of surgical experience.Chirurgia italiana. 59 - 5, pp. 611 - 636.\n(Italia): 2007. ISSN 0009-4773\n\nChapters in books\n\t\n' Salvador Pastor Idoate; Salvatore Di Lauro; Jose Carlos Pastor Jimeno. PVR: Pathogenesis, Histopathology and Classification. Proliferative Vitreoretinopathy with Small Gauge Vitrectomy. Springer, 2018. ISBN 978-3-319-78445-8\nDOI: 10.1007/978-3-319-78446-5_2. \n\n' Salvatore Di Lauro; Maria Isabel Lopez Galvez. Quistes vítreos en una mujer joven. Problemas diagnósticos en patología retinocoroidea. Sociedad Española de Retina-Vitreo. 2018.\n\n' Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor Jimeno. iOCT in PVR management. OCT Applications in Opthalmology. pp. 1 - 8. INTECH, 2018. DOI: 10.5772/intechopen.78774.\n\n' Rosa Coco Martin; Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor. amponadores, manipuladores y tinciones en la cirugía del traumatismo ocular.Trauma Ocular. Ponencia de la SEO 2018..\n\n' LOPEZ GALVEZ; DI LAURO; CRESPO. OCT angiografia y complicaciones retinianas de la diabetes. PONENCIA SEO 2021, CAPITULO 20. (España): 2021.\n\n' Múltiples desprendimientos neurosensoriales bilaterales en paciente joven. Enfermedades Degenerativas De Retina Y Coroides. SERV 04/2016. \n' González-Buendía L; Di Lauro S; Pastor-Idoate S; Pastor Jimeno JC. Vitreorretinopatía proliferante (VRP) e inflamación: LA INFLAMACIÓN in «INMUNOMODULADORES Y ANTIINFLAMATORIOS: MÁS ALLÁ DE LOS CORTICOIDES. RELACION DE PONENCIAS DE LA SOCIEDAD ESPAÑOLA DE OFTALMOLOGIA. 10/2014.",institutionString:null,institution:null},{id:"265335",title:"Mr.",name:"Stefan",middleName:"Radnev",surname:"Stefanov",slug:"stefan-stefanov",fullName:"Stefan Stefanov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/265335/images/7562_n.jpg",biography:null,institutionString:null,institution:null},{id:"243698",title:"Dr.",name:"Xiaogang",middleName:null,surname:"Wang",slug:"xiaogang-wang",fullName:"Xiaogang Wang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243698/images/system/243698.png",biography:"Dr. Xiaogang Wang, a faculty member of Shanxi Eye Hospital specializing in the treatment of cataract and retinal disease and a tutor for postgraduate students of Shanxi Medical University, worked in the COOL Lab as an international visiting scholar under the supervision of Dr. David Huang and Yali Jia from October 2012 through November 2013. Dr. Wang earned an MD from Shanxi Medical University and a Ph.D. from Shanghai Jiao Tong University. Dr. Wang was awarded two research project grants focused on multimodal optical coherence tomography imaging and deep learning in cataract and retinal disease, from the National Natural Science Foundation of China. 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