\r\n\tWe are living in a particularly challenging historical moment. People have learned that no matter how much they control their lives, their environment, and their relationships, everything can be changed instantly, at the fancy of a virus that does not respect age, nationality, ancestry, intelligence, or skills. People learned that the limitless power of science and technology was purely illusory, in the face of an absolute and overwhelming force of nature that was almost no longer recognized. After all, the balance of forces between Nature and science and technology was inevitably shaken and the certainties with which people built their lives were jeopardized by an unpredictable and constantly changing reality. Uncertainty is one of the biggest challenges we face today. Never, as today, people management can make such a difference in their future, both personally and professionally.
\r\n\r\n\t
\r\n\tCHROs need to decide where to focus their resources and attention, select their action priorities. This book will aim to provide the reader with a comprehensive overview of the new challenges of people management and provide keys to (re)think about the new/renewed challenges that the new times, the new “normals” place on those who manage people. From the strategic management of HR to people analytics and HR IT architecture and operation, through the new practices of remote work, this book aims to reflect on the future(s) of people management, illuminating trends and reflecting on potential risks or promising achievements.
The eye is an excellent structure, both an optical and a neuronal device. There are many diseases related to the eye. Each anatomical part of this organ may show a defect and cause an eye defect. Diabetic retinopathy is one of the most common complications of type I and type II diabetes. One of the main causes of blindness worldwide is diabetic retinopathy. Although glucose controls are helpful for other diabetic complications, they cannot prevent the development of retinopathy. While many studies have been done on the physiology of the retina, there are many unknown dark spots. Studies suggest that radicals derived from reactive oxygen play an important role in the development of diabetic retinopathy. Due to high oxygen consumption, the brain and retina are very sensitive to oxidative stress. Oxidative stress has been found to cause brain and retinal damage in both diabetic humans and experimentally diabetic rats. Although various hypoglycemic drugs have been developed for the treatment of diabetes mellitus (DM), complications associated with diabetes remain major medical problems. Therefore, the development of new treatments is of great interest. The mechanisms in the development and progression of diabetic retinopathy are not yet fully understood as they are multifactorial and complex. Stem cell therapies for retinal diseases have been around for a long time. Few clinical trials are currently showing improvement [1].
The eye is the site of many acute or chronic physiopathological disorders, reversible or not, that can lead to partial or total vision loss or major changes in the quality of patients’ life. The search for innovative therapeutic strategies to correct these disorders is an important current issue. Gene and cell therapies are powerful therapeutic tools, but controlling the properties and spread of the injected material is a parameter that limits its application in humans. Anatomical isolation of the eye and ease of access, on the other hand, enable the use of such treatments, which have been previously developed in tissues and whose clinical application is complex [2].
Hillard Lazarus used mesenchymal stem cell (MSC) for the first time in 1995. Today, there are more than 400 applications in a wide variety of clinical fields such as inflammatory pathologies or immunological, fibrotic, or neurological disorders [3].
The use of MSC, which has a great potential, is promising for the treatment of many degenerative disorders, including the eye. In retinal degenerative diseases, MSC ameliorated retinal neurons and retinal pigmented epithelial cells in both
The development of modern life has brought with it an inactive life [5]. The human population is constantly increasing, and diseases are also increasing. In addition, the expectation of prolonging life, lifestyle, and dietary habits that support obesity creates possible conditions for the development of diabetes. Diabetes is shown as the third cause of death in industrialized countries after cardiovascular diseases and cancer. It is stated that about 110 million people on a global scale suffer from diabetes mellitus. This type of diabetes is also called diabetes mellitus. The main symptom of this disease is the presence of sugar in the urine. A diabetic patient occurs every 8 minutes according to the research of a health institution. DM is the inability of sugar to enter the cell and perform its function as a result of the insufficiency of pancreatic insulin secretion or the ineffectiveness of insulin or the inability of insulin to function due to structural defects in the insulin molecule. Insulin produced in the pancreas is responsible for the transition of blood glucose into cells. When insulin is deficient, the level of glucose in the blood increases and it increases the permeability of the vessel by causing defects in the inner surface and outer wall of the vessel in the vascular tissue. Diabetes damages the retina the most in the eye tissue. It is predicted that diabetes mellitus will rise sharply in the next decade. Patients with diabetes suffer from life-limiting and threatening complications and suffer from diseases such as stroke, peripheral arterial diseases, and retinopathy. [6]. Diabetic retinopathy is the most common microvascular complication of DM, resulting in blindness worldwide. Diabetic retinopathy (DR) is a global problem, affecting approximately 100 million people worldwide. Blindness is 25 times more common in diabetic patients than in non-diabetic patients. DR is the most common cause of blindness in patients aged 20–64 years in developed countries. The prevalence of the disease is related to the age of the cases and the duration of the disease. Biochemical changes detected in diabetic retinopathy increased oxidative stress, nonenzymatic glycosylation, protein kinase-C activation, polyol pathway, and increased nitric oxide [7].
Retinal neurons provide normal visual function. Vision loss in diabetes should be explained as a disorder in the function of neurons. To date, most research has generally focused on retinal vascular changes rather than the effect of diabetes on the neural retina. As a result of many studies, it has been determined that changes in neuronal function and vitality are effective in the pathological mechanism of diabetic retinopathy that starts in the early stage of diabetes. Neurophysiological changes have been observed immediately after the onset of diabetes in both humans and experimental animals [8].
The most common cause of retinopathy is diabetes. Retinopathy is responsible for about a third of vision loss and blindness in children. Microaneurysms, non-perfusion capillaries, hemorrhages and/or lipoprotein exudates, which are the onset of DR, indicate that DR is primarily a microvascular disease [9]. There is ample evidence of early retinal neurodegenerations in diabetes. Neuronal degenerations and early retinal disorders were observed in some animal models and studies in humans before the onset of diabetic vasculopathy [10]. Neurodegeneration, which causes thinning of the retina layer in animal studies, is not only limited to cell death and tissue loss but also causes functional disorders in neurotransmitters [11]. The most prominent feature of neurodegenerative diseases is increased neuronal loss with apoptosis. Increasing neuron frequency is accepted as an important component of pathology in diabetic retinopathy. Early studies characterized vascular lesions in postmortem specimens of human retinas [12, 13, 14].
Indeed, neurophysiological changes have been observed immediately after the onset of diabetes in both humans and experimental animals. It has been reported that vascular changes such as permeability changes during diabetes occur 8 days after the onset of diabetes in rats. Capillary dilation and increased blood flow are the earliest signs of diabetes in both humans and animals. Capillaries begin to close within a few years in dogs whereas in about 1 year of diabetes in rats. Typical retinopathy begins to develop in humans at 5–10 years, with microaneurysm, hemorrhage, macular edema, and neovascularization. The neural retina is transparent and invisible, so it is not visible on clinical examination. Vascular changes provide information about the course of the disease and the possibility of blindness. Apart from insulin therapy, the only proven treatment is laser photocoagulation, which destroys retinal regions with overt vascular disorders. This manipulation reduces macular edema and can improve visual acuity, but it cannot restore normal vision and prevent neuronal loss. If neurodegeneration begins shortly after the onset of diabetes, irreversible neuron damage occurs during laser therapy. Early neurophysiological and neurodegenerative changes should be considered as targets for current DR treatments. Psychophysical measurements also showed changes in vision in the early stage of diabetes onset. Contrast sensitivity decreases especially at mid and low spatial frequencies [1, 15].
Obesity is a major health problem in the world that is responsible for type II diabetes mellitus (DM) and its serious complications, such as retinopathy, cardiovascular disease, and nephropathy. In diabetic eyes, neovascularization results in blindness through a vitreous hemorrhage, retinal detachment, or glaucoma. Retinal hypoxia is the crucial factor for these complications [16]. Diabetic retinopathy is one of the most common complications of type I and type II diabetes. One of the main causes of blindness worldwide is diabetic retinopathy. Although glucose controls are helpful for other diabetic complications, they cannot prevent the development of retinopathy. The pathology of retinopathy is due to the deterioration of the vessels of the eye, which occurs due to various metabolic disorders in diabetic patients. These metabolic disturbances range from the level of vascular endothelial growth factor (VEGF) to the accumulation of end products of its glycosylation. The primarily tissue-damaging effects of chronic hyperglycemia cause a complex interplay of multiple mechanisms, which cause abnormal permeability within the retinal vessels, and occlusion with ischemia and subsequent neovascularization. Current treatments include laser photocoagulation and vitreotomy, but these treatments are not curative and do not target the pathological mechanism of the disease. Various studies have been conducted in diabetic rats and human models. Immunohistochemical studies were able to show that intravitreally injected stem cells were localized to the inner retina and it has been stated that this increases visual function. Human clinical trials are ongoing to evaluate the safety, success, and utility of hematopoietic stem cell (HSC) injection in treating retinal vascular diseases. Two patients with diabetic retinopathy injected with HCC showed improvement in visual acuity and ophthalmic measurements even 12 weeks after treatment. The mechanism of the behavior of HSC is unclear, but is thought to be dependent on paracrine signaling. In animal models, intravitreal HSC has been shown to improve retinal damage caused by light, ischemia, and diabetes. Apart from HSC, other stem cells such as mesenchymal stem cell (MSC), endothelial progenitor cell (EPC), and adipose stromal cell are also being investigated for their use in the treatment of diabetic retinopathy. Diabetes mellitus causes both functional and structural deficiencies by affecting both the peripheral and central nervous systems. Peripheral disorders develop within a few weeks after the onset of diabetes, while central disorders take months to develop [17]. Diabetic retinopathy is a major complication of diabetes. However, the effect of a prediabetic condition on the retina has not been clarified. Prediabetes refers to a metabolic disorder defined by glycemic variables lower than diabetes but higher than normoglycemia and considered a high-risk condition for the development of diabetes. It has been stated that the majority of prediabetic patients will eventually develop diabetes [18, 19]. Current treatments for DR as laser photocoagulation, intravitreal anti-VEGF agents, intravitreal corticosteroids, and vitreoretinal surgery are applicable only at advanced stages of the DR and are associated with significant adverse effects [20]. Therefore, new treatments for the early stages of the DR are needed. Retinal diseases are the leading cause of vision loss in the world. Because of the ability of stem cells to self-renewal and differentiation to various types of cells, stem cells are becoming an attractive source of cell therapy in repairing damaged cells as retina pigment epithelium or photoreceptors. Consequently, retinal stem cell therapy is one of the promising therapeutic alternatives to recover vision [21].
The organism begins to form from a cell and then develops into a complete organism with more than 200 cell types. This phylogenetic trend, the tendency to switch from pluripotent cells to mature cells is an integral part of human development. This process, in which cells differentiate and turn into cells without plasticity, is necessary to form all special tissues of the human and to minimize the risk of tumor proliferation. Basically, for a cell to be accepted as a stem cell, this cell should first be able to renew itself without losing its plasticity, and then lose its plasticity and differentiate into different sub-cell types [22]. A stem cell is an undifferentiated cell with the capacity to self-renewal and differentiate. These cells have also the capacity to differentiate into special cells that make up tissues and organs. Self-renewal is the capacity for a cell to reproduce indefinitely by maintaining its undifferentiated state. Differentiation potential is the capacity for a cell to differentiate into one or more types of mature cells.
In addition, stem cells are also characterized by maintaining a certain calm-stagnant state, apart from their capacity for self-renewal and differentiation. This quiescent phase is the G0 phase of the cell cycle, in which cells enter in the absence of mitotic factors. With this calm phase, stem cells can protect themselves against possible “attacks” and maintain their vitality. However, none of these features are sufficient to define the ‘root’ character of the cell. In fact, it should have the potential to rebuild the tissue’s excellent function in the long run. This means a large number of cellular divisions and differentiation
The two largest types of stem cells in mammals are embryonic stem cells isolated from the inner cell mass of the blastocyst and adult stem cells found in most adult tissues.
They are the first discovered and studied stem cells. They are cells that can renew themselves and have the capacity to differentiate into all cell types that can form a whole organism.
With the development of the embryo, embryonic pluripotent stem cells are replaced by stem cells with a more limited capacity, which will provide organ and tissue formation. Cells of different tissues are now specialized. Organs need a mechanism to regenerate cells by replacing cells lost by apoptosis or lesion, thus maintaining their homeostasis. An adult loses about 20 billion cells in a day. This requires a permanent restructuring system [26]. Some organs such as the brain, heart, and kidney are less regenerated [27]. On the other hand, tissues such as bone marrow, skin, and intestines are constantly renewed. To ensure the regeneration prosess, organs have a cell reservoir; adult stem cells which serve throughout life. Their stocks are provided by the balance between self-renewal and differentiation capacities. Adult stem cells are also known as somatic stem cells. It is assumed that all organs of the body have mature stem cells, and in most organs, they are active throughout life. They constantly form new cells to ensure tissue regeneration (skin, cornea, bone marrow, intestine) [28, 29, 30]. In some organs, these cells become active after birth and then go into dormancy. We see them in organs with slow or almost no cellular regeneration; it is seen only in organs such as the brain and liver, where stem cells divide only during serious injuries or rarely [31, 32]. Hematopoietic stem cells, stromal stem cells, and stem cells in organs are adult stem cells.
Bone marrow contains two types of cells: hematopoietic stem cells (HSC) and stromal mesenchymal stem cells (MSC). HSC can form all mature hematopoietic cells such as myeloid and lymphoid. MSC plays a supportive role in hematopoiesis. Bone marrow also contains other types of cells. Progenitor endothelial cells (PEC) are found in the marrow as well as adult multipotent progenitor cells [33]. When necessary, PEH enters the circulation and plays a role in angiogenesis. In addition, some studies refer to bone marrow stem cells (F-MSCs), which represent a heterogeneous stem cell population. These cells can differentiate into many different types of cells, such as hepatocytes, endothelial cells, epithelial cells, cardiac or skeletal muscle cells, neuronal cells, or astrocytes. This indicates that bone marrow cells have the potential to differentiate into cells of another tissue [34]. Stem cells are ubiquitous. Some niches are yet to be discovered. Although bone marrow-derived stem cells have been cited as a potential resource for regenerative therapy, their potential and usefulness are still open to debate [35, 36].
Deterioration in tissues or organ functions for any reason constitutes a very important problem in terms of seriously affecting an individual’s quality of life. For this reason, regenerative medicine is concerned with repairing the damage and restoring normal body functions through stem cell therapies. Advances in stem cell research have shown cell-based therapy as a useful option to treat medically incurable diseases [36]. Stem cells can migrate to damaged tissue. The effect and cellular mechanisms of stem cells vary according to their environment. They have excellent plasticity that allows these cells to adapt to their environment and act appropriately [33].
“Plasticity” is the ability of a stem cell to acquire different differentiation programs under certain microenvironmental conditions. Endogenous MSC or exogenously administered MSC can migrate to the injured tissue and participate in its healing. The therapeutic effects of MSC can be attributed to its ability to secrete a wide variety of paracrine factors. These mechanisms are likely independent, but they can also act together. In many cases, a combination of these protective mechanisms can work together to heal the damage [37]. However, the mechanism of the therapeutic effect of stem cell is still open to debate. There are two basic explanations; these are cell differentiation and the paracrine effect of stem cells. The combination of these two mechanisms seems to be a third theory [38].
Retinal degenerations are pathologies that affect the light-sensitive cells of the retina, photoreceptors, cones, and rods. Cell therapy is accepted as an interesting alternative for retinal degenerations. A mouse model of retinal degeneration has been shown to improve visual function after transplantation of photoreceptors [39]. Other cells, including MSC, also show great potential by altering photoreceptors or protecting against degenerations due to their paracrine effects [40]. Some researchers also emphasize that MSC can differentiate into retinal cells, especially photoreceptor-like cells. This plasticity feature of MSC has been observed
In general, cellular therapy works in two ways: to replace dead cells in the tissue to restore tissue function or to prevent/attenuate/slow tissue degeneration by reducing inflammatory infiltration or reduce apoptosis and cell death phenomena.
The eye is a small organ, and the number of stem cells required therapeutically is theoretically less than in larger organs. Compared to other internal organs, the retinal environment is easily accessible with small-gauge vitrectomy needles, greatly increasing the potential for stem cell-based therapy for the treatment of retinal degenerative diseases. The retina is layered and thin. It depends on the preservation of cells, nerve anatomy, and synaptic networks to maintain vision. Retinal neuron connectivity is an important therapeutic goal to alleviate blindness in millions of people worldwide for the preservation or restoration of the original neural structure of the retina and photoreceptor [43]. The emergence of studies shows the possibility of cell regeneration in the adult central nervous system, which makes it possible to envision the implantation of stem cells or progenitor cells as an approach to cell therapy. The restorative approach offers strong hope, given that key questions about the biology of development need to be explored. The transplantation of differentiated or undifferentiated retinal tissue (embryonic, newborn) in the subretinal position of the graft poses the problem of its structural and functional organization.
It is seen that different types of stem cells are used considering transplantation studies. When we look at transplantation studies, in studies using different types of stem cells (retina progenitor cell, neural stem cell, bone marrow-derived stem cell, and embryonic stem cell), although they settle in the retina, they are not able to express retinal-specific markers and cannot establish synaptic connections are encountered [44].
The discovery of stem cells has caused great excitement in the hopes of using such treatments to restore vision. Already, stem cells in the anterior segment of the eye have a remarkable clinical effect. Stem cell therapy provides re-epithelialization of the cornea and improves vision. The trabecular meshwork, located on the inner side of the junction of the sclera and the cornea, can also be regenerated with stem cells [38]. However, the most interesting studies have been done in the posterior segment of the eye. Most retinal degenerations begin with the loss of a neuron or damage to a neuron. Therefore, these cells should be replaced with a cell layer that is differentiated and functional in the appropriate medium. Sometimes pathology develops and destroys many cells. In this case, a graft consisting of several layers is required. To perform a transplant treatment for blindness, progenitor neuronal cells are isolated and transferred to different cells of the retina.
Studies on neuronal cell cultures that can differentiate are done. Today, very few of these differentiation mechanisms have been fully elucidated. Therefore, the use of cell transplantation in the retina seems distant [45].
Considering that stem cell therapy is promising in retinal diseases, studies were started with embryonic stem cells, and induced pluripotent stem cells were obtained. Many retinal cells such as retinal pigment epithelium, photoreceptors, and ganglion cells were obtained from induced pluripotent stem cells [46].
It is stated that the neuroretina, which is attached to the pigment epithelium (RPE), has a complex structure. Therefore, it has been stated that there are three different cells that can be considered in cell therapy: neuroretina (photoreceptors, bipolar cells, ganglion cells, and glial cells), RPEs, and vascular endothelial cells. Depending on retinal diseases, strategies to place different cells need to be developed [47].
Diabetic retinopathy (DR) is one of the largest causes of vision loss worldwide. The use of autologous stem cells for organ reconstruction offers a potential solution for the replacement of tissue or whole organs mechanisms in the development and progression of DR are not fully understood yet. Although many studies have been done about retinal physiology, many unknown dark spots are available about it. Stem cell therapy appears to be a possible option both to prevent neurovascular damage and to repair the damaged retina. Mesenchymal stem cell attracts great attention in retinal degenerations due to their ability to differentiate into neurons. However, the way and amount of stem cell administration will create different effects, it is important to know the effect of cell therapy on body after administration in relation to its use in the clinical practice.
To date, no treatment has been developed for the regeneration of retinal vasculature damage resulting from prolonged hyperglycemia. Cell therapy seems to be a possible option both to prevent neurovascular damage and to repair damaged retina [48]. Although clinical evaluations and retinal autopsies of diabetic patients provide information about the progression and features of diabetic retinopathy, its pathophysiological mechanism is not yet understood. Studies on animal models continue in order to better understand the development of diabetic retinopathy at the molecular and cellular level [49]. Retina, in the nervous system, provides a suitable environment to study the functions and distribution of stem cells. It is stated that intravenously administered mesenchymal stem cell transplantation can inhibit retinal apoptotic cells, reduce inflammatory responses, and limit the spread of damage [50].
In a study in which intravitreal mesenchymal stem cell application was performed, some physiological parameters were examined and it was seen that although there were decreases in body weight in diabetics, there was no change in body weight in the group administered intravitreal stem cells. These findings were interesting for us. While it was reported that body weight increased significantly in the mouse model in which the human adipose tissue-derived mesenchymal stem cell was transplanted
As a result, more clinical trials should evaluate the application methods, the timing of the practice, using cell count and repetition dose of stem cell and their results. In the near future, the regenerative stem cell therapy may be a standard treatment in many degenerative eye disorders.
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\n\nWe have adopted the Protocol to increase the number of readers of our publications. All our Works are more widely accessible, with resulting benefits for scholars, researchers, students, libraries, universities and other academic institutions. Through this method of exposing metadata, IntechOpen enables citation indexes, scientific search engines, scholarly databases, and scientific literature collections to gather metadata from our repository and make our publications available to a broader academic audience.
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I received a B.Eng. degree in Computer Engineering with First Class Honors in 2008 from Prince of Songkla University, Songkhla, Thailand, where I received a Ph.D. degree in Electrical Engineering. My research interests are primarily in the area of biomedical signal processing and classification notably EMG (electromyography signal), EOG (electrooculography signal), and EEG (electroencephalography signal), image analysis notably breast cancer analysis and optical coherence tomography, and rehabilitation engineering. I became a student member of IEEE in 2008. During October 2011-March 2012, I had worked at School of Computer Science and Electronic Engineering, University of Essex, Colchester, Essex, United Kingdom. In addition, during a B.Eng. I had been a visiting research student at Faculty of Computer Science, University of Murcia, Murcia, Spain for three months.\n\nI have published over 40 papers during 5 years in refereed journals, books, and conference proceedings in the areas of electro-physiological signals processing and classification, notably EMG and EOG signals, fractal analysis, wavelet analysis, texture analysis, feature extraction and machine learning algorithms, and assistive and rehabilitative devices. I have several computer programming language certificates, i.e. Sun Certified Programmer for the Java 2 Platform 1.4 (SCJP), Microsoft Certified Professional Developer, Web Developer (MCPD), Microsoft Certified Technology Specialist, .NET Framework 2.0 Web (MCTS). I am a Reviewer for several refereed journals and international conferences, such as IEEE Transactions on Biomedical Engineering, IEEE Transactions on Industrial Electronics, Optic Letters, Measurement Science Review, and also a member of the International Advisory Committee for 2012 IEEE Business Engineering and Industrial Applications and 2012 IEEE Symposium on Business, Engineering and Industrial Applications.",institutionString:null,institution:{name:"Joseph Fourier University",country:{name:"France"}}},{id:"55578",title:"Dr.",name:"Antonio",middleName:null,surname:"Jurado-Navas",slug:"antonio-jurado-navas",fullName:"Antonio Jurado-Navas",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",biography:"Antonio Jurado-Navas received the M.S. degree (2002) and the Ph.D. degree (2009) in Telecommunication Engineering, both from the University of Málaga (Spain). He first worked as a consultant at Vodafone-Spain. From 2004 to 2011, he was a Research Assistant with the Communications Engineering Department at the University of Málaga. In 2011, he became an Assistant Professor in the same department. From 2012 to 2015, he was with Ericsson Spain, where he was working on geo-location\ntools for third generation mobile networks. Since 2015, he is a Marie-Curie fellow at the Denmark Technical University. 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We presented a geomorphological analysis of the Wagad highland providing new constraints on the evolution of river network. The shallow to deeper nature of fault and their response to development of hydrological networks has been analyzed using seismic tomography. Based on surface drainage offset and seismic structures several E-W oriented faults controlling fluvial dynamics are identified. From seismic structures and drainage offset it is clear that the fluvial dynamics is controlled by shallower to deeper faults. The estimated attributes are well supported with seismic structures and focal mechanisms solutions. Based on fluvial offset and seismic structure analysis a new tectonic model has been proposed for WH. The tectonic model shows that the faults WH are well connected at deeper level and generated negative flower structures and significantly controlling surface fluvial dynamics.",book:{id:"6130",slug:"tectonics-problems-of-regional-settings",title:"Tectonics",fullTitle:"Tectonics - Problems of Regional Settings"},signatures:"Girish Ch Kothyari, Ajay P. 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Oyinloye",authors:[{id:"68497",title:"Prof.",name:"Akindele",middleName:null,surname:"Oyinloye",slug:"akindele-oyinloye",fullName:"Akindele Oyinloye"}]},{id:"68134",title:"Introductory Chapter: Earth Crust - Origin, Structure, Composition and Evolution",slug:"introductory-chapter-earth-crust-origin-structure-composition-and-evolution",totalDownloads:1979,totalCrossrefCites:1,totalDimensionsCites:4,abstract:null,book:{id:"8476",slug:"earth-crust",title:"Earth Crust",fullTitle:"Earth Crust"},signatures:"Muhammad Nawaz",authors:[{id:"269790",title:"Dr.",name:"Muhammad",middleName:null,surname:"Nawaz",slug:"muhammad-nawaz",fullName:"Muhammad Nawaz"}]},{id:"75063",title:"An Overview on the Classification and Tectonic Setting of Neoproterozoic Granites of the Nubian Shield, Eastern Desert, Egypt",slug:"an-overview-on-the-classification-and-tectonic-setting-of-neoproterozoic-granites-of-the-nubian-shie",totalDownloads:1289,totalCrossrefCites:1,totalDimensionsCites:2,abstract:"Granites constitute the main rock components of the Earth’s continental crust, which suggested to be formed in variable geodynamics environments. The different types of granitic rocks, their compositional characteristics, tectonic settings and magma sources are outlined. Mineralogical classification of granites includes four rock types: tonalites, granodiorites, granite (monzogranite and syenogranites) and alkali-feldspar granites. Alphabetical classification subdivided granites into: I-type, S-type, A-type and M-type granites. Moreover, formation of granitic magmas requires distinctive geodynamic settings such as: volcanic arc granite (Cordilleran); collision-related granites (leucogranites); intra-plate and ocean ridge granites. The Eastern Desert of Egypt (ED) forms the northern part of Nubian Shield. Both older and younger granites are widely exposed in the ED. Old granites (OG) comprise tonalites and granodiorites of syn- to late-orogenic granitoid assemblages. They are calcalkaline, I-type, metaluminous and display island arc tectonic setting. Younger granites (YG) on the other hand, include granites, alkali-feldspar granites and minor granodiorites. They are of I- and A-type granites and of post-orogenic to anorogenic tectonic settings. The majority of the YG are alkaline, A-type granite and of within-plate tectonic setting (WPG). The A-type granites are subdivided into: A2-type postorogenic granites and A1-type anorogenic granites. Granite magma genesis involves: (a) fractional crystallization of mafic mantle-derived magmas; (b) anatexis or assimilation of old, upper crustal rocks (c) re - melting of juvenile mafic mantle – derived rocks underplating the continental crust. Generally, older I-type granitoids were interpreted to result from melting of mafic crust and dated at approximately 760–650 Ma, whereas younger granites suggested to be formed as a result of partial melting of a juvenile Neoproterozoic mantle source. Moreover, they formed from anatectic melts of various crustal sources that emplaced between 600 and 475 Ma.",book:{id:"9879",slug:"geochemistry",title:"Geochemistry",fullTitle:"Geochemistry"},signatures:"Gaafar A. El Bahariya",authors:[{id:"267666",title:"Dr.",name:"Gaafar",middleName:null,surname:"El Bahariya",slug:"gaafar-el-bahariya",fullName:"Gaafar El Bahariya"}]},{id:"59828",title:"Evolution of Drainage in Response to Brittle - Ductile Dynamics and Surface Processes in Kachchh Rift Basin, Western India",slug:"evolution-of-drainage-in-response-to-brittle-ductile-dynamics-and-surface-processes-in-kachchh-rift-",totalDownloads:1538,totalCrossrefCites:7,totalDimensionsCites:22,abstract:"The eastern part of Kachchh Rift basin was reactivated after 2001 Bhuj earthquake of Mw 7.7 and continuous seismicity has been recorded since then. The northern part of Wagad upland also experienced moderate earthquakes Mw ≥ 5.7 in February 2006 and March 2007. 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The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"10",title:"Physiology",doi:"10.5772/intechopen.72796",issn:"2631-8261",scope:"Modern physiology requires a comprehensive understanding of the integration of tissues and organs throughout the mammalian body, including the cooperation between structure and function at the cellular and molecular levels governed by gene and protein expression. 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His primary area of interest is physiology and pathophysiology of the gastrointestinal (GI) tract, with the major focus on the mechanism of GI mucosal defense, protection, and ulcer healing. He was a postdoctoral NIH fellow at the University of California and the Gastroenterology VA Medical Center, Irvine, Long Beach, CA, USA, and at the Gastroenterology Clinics Erlangen-Nuremberg and Munster in Germany. 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Other positions she has held at the university include Vice-Dean of Master Programs, Vice-Dean of the Degree in Biology and Vice-Dean for Mobility and Enterprise and Engagement at the Faculty of Science (University of Alicante). She received her Bachelor in Biology in 1998 (University of Alicante) and her PhD in 2003 (Biochemistry, University of Alicante). She undertook post-doctoral research at the University of East Anglia (Norwich, U.K. 2004-2005; 2007-2008).\nHer multidisciplinary research focuses on investigating archaea and their potential applications in biotechnology. She has an H-index of 21. She has authored one patent and has published more than 70 indexed papers and around 60 book chapters.\nShe has contributed to more than 150 national and international meetings during the last 15 years. Her research interests include archaea metabolism, enzymes purification and characterization, gene regulation, carotenoids and bioplastics production, antioxidant\ncompounds, waste water treatments, and brines bioremediation.\nRosa María’s other roles include editorial board member for several journals related\nto biochemistry, reviewer for more than 60 journals (biochemistry, molecular biology, biotechnology, chemistry and microbiology) and president of several organizing committees in international meetings related to the N-cycle or respiratory processes.",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"15",title:"Chemical Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",isOpenForSubmission:!0,annualVolume:11411,editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",slug:"sukru-beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",biography:"Dr. Şükrü Beydemir obtained a BSc in Chemistry in 1995 from Yüzüncü Yıl University, MSc in Biochemistry in 1998, and PhD in Biochemistry in 2002 from Atatürk University, Turkey. 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He is a member of the Turkish Biochemical Society, American Chemical Society, and German Genetics society. Dr. Ekinci published around ninety scientific papers, reviews and book chapters, and presented several conferences to scientists. He has received numerous publication awards from several scientific councils. Dr. Ekinci serves as the Editor in Chief of four international books and is involved in the Editorial Board of several international journals.",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null},{id:"17",title:"Metabolism",coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",isOpenForSubmission:!0,annualVolume:11413,editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",slug:"yannis-karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",biography:"Yannis Karamanos, born in Greece in 1953, completed his pre-graduate studies at the Université Pierre et Marie Curie, Paris, then his Masters and Doctoral degree at the Université de Lille (1983). He was associate professor at the University of Limoges (1987) before becoming full professor of biochemistry at the Université d’Artois (1996). He worked on the structure-function relationships of glycoconjugates and his main project was the investigations on the biological roles of the de-N-glycosylation enzymes (Endo-N-acetyl-β-D-glucosaminidase and peptide-N4-(N-acetyl-β-glucosaminyl) asparagine amidase). From 2002 he contributes to the understanding of the Blood-brain barrier functioning using proteomics approaches. He has published more than 70 papers. His teaching areas are energy metabolism and regulation, integration and organ specialization and metabolic adaptation.",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null},{id:"18",title:"Proteomics",coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",isOpenForSubmission:!0,annualVolume:11414,editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",slug:"paolo-iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",biography:"Paolo Iadarola graduated with a degree in Chemistry from the University of Pavia (Italy) in July 1972. He then worked as an Assistant Professor at the Faculty of Science of the same University until 1984. In 1985, Prof. Iadarola became Associate Professor at the Department of Biology and Biotechnologies of the University of Pavia and retired in October 2017. Since then, he has been working as an Adjunct Professor in the same Department at the University of Pavia. His research activity during the first years was primarily focused on the purification and structural characterization of enzymes from animal and plant sources. During this period, Prof. Iadarola familiarized himself with the conventional techniques used in column chromatography, spectrophotometry, manual Edman degradation, and electrophoresis). Since 1995, he has been working on: i) the determination in biological fluids (serum, urine, bronchoalveolar lavage, sputum) of proteolytic activities involved in the degradation processes of connective tissue matrix, and ii) on the identification of biological markers of lung diseases. In this context, he has developed and validated new methodologies (e.g., Capillary Electrophoresis coupled to Laser-Induced Fluorescence, CE-LIF) whose application enabled him to determine both the amounts of biochemical markers (Desmosines) in urine/serum of patients affected by Chronic Obstructive Pulmonary Disease (COPD) and the activity of proteolytic enzymes (Human Neutrophil Elastase, Cathepsin G, Pseudomonas aeruginosa elastase) in sputa of these patients. More recently, Prof. Iadarola was involved in developing techniques such as two-dimensional electrophoresis coupled to liquid chromatography/mass spectrometry (2DE-LC/MS) for the proteomic analysis of biological fluids aimed at the identification of potential biomarkers of different lung diseases. He is the author of about 150 publications (According to Scopus: H-Index: 23; Total citations: 1568- According to WOS: H-Index: 20; Total Citations: 1296) of peer-reviewed international journals. He is a Consultant Reviewer for several journals, including the Journal of Chromatography A, Journal of Chromatography B, Plos ONE, Proteomes, International Journal of Molecular Science, Biotech, Electrophoresis, and others. He is also Associate Editor of Biotech.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",slug:"simona-viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",biography:"Simona Viglio is an Associate Professor of Biochemistry at the Department of Molecular Medicine at the University of Pavia. She has been working since 1995 on the determination of proteolytic enzymes involved in the degradation process of connective tissue matrix and on the identification of biological markers of lung diseases. She gained considerable experience in developing and validating new methodologies whose applications allowed her to determine both the amount of biomarkers (Desmosine and Isodesmosine) in the urine of patients affected by COPD, and the activity of proteolytic enzymes (HNE, Cathepsin G, Pseudomonas aeruginosa elastase) in the sputa of these patients. Simona Viglio was also involved in research dealing with the supplementation of amino acids in patients with brain injury and chronic heart failure. She is presently engaged in the development of 2-DE and LC-MS techniques for the study of proteomics in biological fluids. The aim of this research is the identification of potential biomarkers of lung diseases. She is an author of about 90 publications (According to Scopus: H-Index: 23; According to WOS: H-Index: 20) on peer-reviewed journals, a member of the “Società Italiana di Biochimica e Biologia Molecolare,“ and a Consultant Reviewer for International Journal of Molecular Science, Journal of Chromatography A, COPD, Plos ONE and Nutritional Neuroscience.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null}]},overviewPageOFChapters:{paginationCount:1,paginationItems:[{id:"81831",title:"Deep Network Model and Regression Analysis using OLS Method for Predicting Lung Vital Capacity",doi:"10.5772/intechopen.104737",signatures:"Harun Sümbül",slug:"deep-network-model-and-regression-analysis-using-ols-method-for-predicting-lung-vital-capacity",totalDownloads:3,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Decision Science - Recent Advances and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/11604.jpg",subseries:{id:"86",title:"Business and Management"}}}]},overviewPagePublishedBooks:{paginationCount:1,paginationItems:[{type:"book",id:"11392",title:"Leadership in a Changing World",subtitle:"A Multidimensional Perspective",coverURL:"https://cdn.intechopen.com/books/images_new/11392.jpg",slug:"leadership-in-a-changing-world-a-multidimensional-perspective",publishedDate:"May 11th 2022",editedByType:"Edited by",bookSignature:"Muhammad Mohiuddin, Bilal Khalid, Md. 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He has published research in Research Policy, Applied Economics, Review of Economic Philosophy, Strategic Change, International Journal of Logistics, Sustainability, Journal of Environmental Management, Journal of Global Information Management, Journal of Cleaner Production, M@N@GEMENT, and more. He is a member of CEDIMES Institut (France), Academy of International Business (AIB), Strategic Management Society (SMS), Academy of Management (AOM), Administrative Science Association of Canada (ASAC), and Canadian council of small business and entrepreneurship (CCSBE). He is currently the director of the Research Group on Contemporary Asia (GERAC) at Laval University. 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He is also a faculty member in the Molecular Oncology Program. He obtained his MSc and Ph.D. at Oregon State University and Texas Tech University, respectively. He pursued his postdoctoral studies at Rutgers University Medical School and the National Institutes of Health (NIH/NIDDK), USA. His research focuses on biochemistry, biophysics, genetics, molecular biology, and molecular medicine with specialization in the fields of drug design, protein structure-function, protein folding, prions, microRNA, pseudogenes, molecular cancer, epigenetics, metabolites, proteomics, genomics, protein expression, and characterization by spectroscopic and calorimetric methods.",institutionString:"University of Health Sciences",institution:null},{id:"180528",title:"Dr.",name:"Hiroyuki",middleName:null,surname:"Kagechika",slug:"hiroyuki-kagechika",fullName:"Hiroyuki Kagechika",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180528/images/system/180528.jpg",biography:"Hiroyuki Kagechika received his bachelor’s degree and Ph.D. in Pharmaceutical Sciences from the University of Tokyo, Japan, where he served as an associate professor until 2004. He is currently a professor at the Institute of Biomaterials and Bioengineering (IBB), Tokyo Medical and Dental University (TMDU). From 2010 to 2012, he was the dean of the Graduate School of Biomedical Science. Since 2012, he has served as the vice dean of the Graduate School of Medical and Dental Sciences. He has been the director of the IBB since 2020. Dr. Kagechika’s major research interests are the medicinal chemistry of retinoids, vitamins D/K, and nuclear receptors. He has developed various compounds including a drug for acute promyelocytic leukemia.",institutionString:"Tokyo Medical and Dental University",institution:{name:"Tokyo Medical and Dental University",country:{name:"Japan"}}},{id:"40482",title:null,name:"Rizwan",middleName:null,surname:"Ahmad",slug:"rizwan-ahmad",fullName:"Rizwan Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/40482/images/system/40482.jpeg",biography:"Dr. Rizwan Ahmad is a University Professor and Coordinator, Quality and Development, College of Medicine, Imam Abdulrahman bin Faisal University, Saudi Arabia. Previously, he was Associate Professor of Human Function, Oman Medical College, Oman, and SBS University, Dehradun. Dr. Ahmad completed his education at Aligarh Muslim University, Aligarh. He has published several articles in peer-reviewed journals, chapters, and edited books. His area of specialization is free radical biochemistry and autoimmune diseases.",institutionString:"Imam Abdulrahman Bin Faisal University",institution:{name:"Imam Abdulrahman Bin Faisal University",country:{name:"Saudi Arabia"}}},{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/41865/images/system/41865.jpg",biography:"Farid A. Badria, Ph.D., is the recipient of several awards, including The World Academy of Sciences (TWAS) Prize for Public Understanding of Science; the World Intellectual Property Organization (WIPO) Gold Medal for best invention; Outstanding Arab Scholar, Kuwait; and the Khwarizmi International Award, Iran. He has 250 publications, 12 books, 20 patents, and several marketed pharmaceutical products to his credit. He continues to lead research projects on developing new therapies for liver, skin disorders, and cancer. Dr. Badria was listed among the world’s top 2% of scientists in medicinal and biomolecular chemistry in 2019 and 2020. He is a member of the Arab Development Fund, Kuwait; International Cell Research Organization–United Nations Educational, Scientific and Cultural Organization (ICRO–UNESCO), Chile; and UNESCO Biotechnology France",institutionString:"Mansoura University",institution:{name:"Mansoura University",country:{name:"Egypt"}}},{id:"329385",title:"Dr.",name:"Rajesh K.",middleName:"Kumar",surname:"Singh",slug:"rajesh-k.-singh",fullName:"Rajesh K. Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329385/images/system/329385.png",biography:"Dr. Singh received a BPharm (2003) and MPharm (2005) from Panjab University, Chandigarh, India, and a Ph.D. (2013) from Punjab Technical University (PTU), Jalandhar, India. He has more than sixteen years of teaching experience and has supervised numerous postgraduate and Ph.D. students. He has to his credit more than seventy papers in SCI- and SCOPUS-indexed journals, fifty-five conference proceedings, four books, six Best Paper Awards, and five projects from different government agencies. He is currently an editorial board member of eight international journals and a reviewer for more than fifty scientific journals. He received Top Reviewer and Excellent Peer Reviewer Awards from Publons in 2016 and 2017, respectively. He is also on the panel of The International Reviewer for reviewing research proposals for grants from the Royal Society. He also serves as a Publons Academy mentor and Bentham brand ambassador.",institutionString:"Punjab Technical University",institution:{name:"Punjab Technical University",country:{name:"India"}}},{id:"142388",title:"Dr.",name:"Thiago",middleName:"Gomes",surname:"Gomes Heck",slug:"thiago-gomes-heck",fullName:"Thiago Gomes Heck",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/142388/images/7259_n.jpg",biography:null,institutionString:null,institution:{name:"Universidade Regional do Noroeste do Estado do Rio Grande do Sul",country:{name:"Brazil"}}},{id:"336273",title:"Assistant Prof.",name:"Janja",middleName:null,surname:"Zupan",slug:"janja-zupan",fullName:"Janja Zupan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/336273/images/14853_n.jpeg",biography:"Janja Zupan graduated in 2005 at the Department of Clinical Biochemistry (superviser prof. dr. Janja Marc) in the field of genetics of osteoporosis. Since November 2009 she is working as a Teaching Assistant at the Faculty of Pharmacy, Department of Clinical Biochemistry. In 2011 she completed part of her research and PhD work at Institute of Genetics and Molecular Medicine, University of Edinburgh. She finished her PhD entitled The influence of the proinflammatory cytokines on the RANK/RANKL/OPG in bone tissue of osteoporotic and osteoarthritic patients in 2012. From 2014-2016 she worked at the Institute of Biomedical Sciences, University of Aberdeen as a postdoctoral research fellow on UK Arthritis research project where she gained knowledge in mesenchymal stem cells and regenerative medicine. She returned back to University of Ljubljana, Faculty of Pharmacy in 2016. She is currently leading project entitled Mesenchymal stem cells-the keepers of tissue endogenous regenerative capacity facing up to aging of the musculoskeletal system funded by Slovenian Research Agency.",institutionString:null,institution:{name:"University of Ljubljana",country:{name:"Slovenia"}}},{id:"357453",title:"Dr.",name:"Radheshyam",middleName:null,surname:"Maurya",slug:"radheshyam-maurya",fullName:"Radheshyam Maurya",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/357453/images/16535_n.jpg",biography:null,institutionString:null,institution:{name:"University of Hyderabad",country:{name:"India"}}},{id:"311457",title:"Dr.",name:"Júlia",middleName:null,surname:"Scherer Santos",slug:"julia-scherer-santos",fullName:"Júlia Scherer Santos",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/311457/images/system/311457.jpg",biography:"Dr. Júlia Scherer Santos works in the areas of cosmetology, nanotechnology, pharmaceutical technology, beauty, and aesthetics. Dr. Santos also has experience as a professor of graduate courses. Graduated in Pharmacy, specialization in Cosmetology and Cosmeceuticals applied to aesthetics, specialization in Aesthetic and Cosmetic Health, and a doctorate in Pharmaceutical Nanotechnology. Teaching experience in Pharmacy and Aesthetics and Cosmetics courses. She works mainly on the following subjects: nanotechnology, cosmetology, pharmaceutical technology, aesthetics.",institutionString:"Universidade Federal de Juiz de Fora",institution:{name:"Universidade Federal de Juiz de Fora",country:{name:"Brazil"}}},{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",slug:"abdulsamed-kukurt",fullName:"Abdulsamed Kükürt",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRNVJQA4/Profile_Picture_2022-03-07T13:23:04.png",biography:"Dr. Kükürt graduated from Uludağ University in Turkey. He started his academic career as a Research Assistant in the Department of Biochemistry at Kafkas University. In 2019, he completed his Ph.D. program in the Department of Biochemistry at the Institute of Health Sciences. He is currently working at the Department of Biochemistry, Kafkas University. He has 27 published research articles in academic journals, 11 book chapters, and 37 papers. He took part in 10 academic projects. He served as a reviewer for many articles. He still serves as a member of the review board in many academic journals.",institutionString:null,institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"178366",title:"Associate Prof.",name:"Volkan",middleName:null,surname:"Gelen",slug:"volkan-gelen",fullName:"Volkan Gelen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178366/images/system/178366.jpg",biography:"Volkan Gelen is a Physiology specialist who received his veterinary degree from Kafkas University in 2011. Between 2011-2015, he worked as an assistant at Atatürk University, Faculty of Veterinary Medicine, Department of Physiology. In 2016, he joined Kafkas University, Faculty of Veterinary Medicine, Department of Physiology as an assistant professor. Dr. Gelen has been engaged in various academic activities at Kafkas University since 2016. There he completed 5 projects and has 3 ongoing projects. He has 60 articles published in scientific journals and 20 poster presentations in scientific congresses. His research interests include physiology, endocrine system, cancer, diabetes, cardiovascular system diseases, and isolated organ bath system studies.",institutionString:"Kafkas University",institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"418963",title:"Dr.",name:"Augustine Ododo",middleName:"Augustine",surname:"Osagie",slug:"augustine-ododo-osagie",fullName:"Augustine Ododo Osagie",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/418963/images/16900_n.jpg",biography:"Born into the family of Osagie, a prince of the Benin Kingdom. I am currently an academic in the Department of Medical Biochemistry, University of Benin. Part of the duties are to teach undergraduate students and conduct academic research.",institutionString:null,institution:{name:"University of Benin",country:{name:"Nigeria"}}},{id:"192992",title:"Prof.",name:"Shagufta",middleName:null,surname:"Perveen",slug:"shagufta-perveen",fullName:"Shagufta Perveen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192992/images/system/192992.png",biography:"Prof. Shagufta Perveen is a Distinguish Professor in the Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. Dr. Perveen has acted as the principal investigator of major research projects funded by the research unit of King Saud University. She has more than ninety original research papers in peer-reviewed journals of international repute to her credit. She is a fellow member of the Royal Society of Chemistry UK and the American Chemical Society of the United States.",institutionString:"King Saud University",institution:{name:"King Saud University",country:{name:"Saudi Arabia"}}},{id:"49848",title:"Dr.",name:"Wen-Long",middleName:null,surname:"Hu",slug:"wen-long-hu",fullName:"Wen-Long Hu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49848/images/system/49848.jpg",biography:"Wen-Long Hu is Chief of the Division of Acupuncture, Department of Chinese Medicine at Kaohsiung Chang Gung Memorial Hospital, as well as an adjunct associate professor at Fooyin University and Kaohsiung Medical University. Wen-Long is President of Taiwan Traditional Chinese Medicine Medical Association. He has 28 years of experience in clinical practice in laser acupuncture therapy and 34 years in acupuncture. He is an invited speaker for lectures and workshops in laser acupuncture at many symposiums held by medical associations. He owns the patent for herbal preparation and producing, and for the supercritical fluid-treated needle. Dr. Hu has published three books, 12 book chapters, and more than 30 papers in reputed journals, besides serving as an editorial board member of repute.",institutionString:"Kaohsiung Chang Gung Memorial Hospital",institution:{name:"Kaohsiung Chang Gung Memorial Hospital",country:{name:"Taiwan"}}},{id:"298472",title:"Prof.",name:"Andrey V.",middleName:null,surname:"Grechko",slug:"andrey-v.-grechko",fullName:"Andrey V. Grechko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/298472/images/system/298472.png",biography:"Andrey Vyacheslavovich Grechko, Ph.D., Professor, is a Corresponding Member of the Russian Academy of Sciences. He graduated from the Semashko Moscow Medical Institute (Semashko National Research Institute of Public Health) with a degree in Medicine (1998), the Clinical Department of Dermatovenerology (2000), and received a second higher education in Psychology (2009). Professor A.V. Grechko held the position of Сhief Physician of the Central Clinical Hospital in Moscow. He worked as a professor at the faculty and was engaged in scientific research at the Medical University. Starting in 2013, he has been the initiator of the creation of the Federal Scientific and Clinical Center for Intensive Care and Rehabilitology, Moscow, Russian Federation, where he also serves as Director since 2015. He has many years of experience in research and teaching in various fields of medicine, is an author/co-author of more than 200 scientific publications, 13 patents, 15 medical books/chapters, including Chapter in Book «Metabolomics», IntechOpen, 2020 «Metabolomic Discovery of Microbiota Dysfunction as the Cause of Pathology».",institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"199461",title:"Prof.",name:"Natalia V.",middleName:null,surname:"Beloborodova",slug:"natalia-v.-beloborodova",fullName:"Natalia V. Beloborodova",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/199461/images/system/199461.jpg",biography:'Natalia Vladimirovna Beloborodova was educated at the Pirogov Russian National Research Medical University, with a degree in pediatrics in 1980, a Ph.D. in 1987, and a specialization in Clinical Microbiology from First Moscow State Medical University in 2004. She has been a Professor since 1996. Currently, she is the Head of the Laboratory of Metabolism, a division of the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russian Federation. N.V. Beloborodova has many years of clinical experience in the field of intensive care and surgery. She studies infectious complications and sepsis. She initiated a series of interdisciplinary clinical and experimental studies based on the concept of integrating human metabolism and its microbiota. Her scientific achievements are widely known: she is the recipient of the Marie E. Coates Award \\"Best lecturer-scientist\\" Gustafsson Fund, Karolinska Institutes, Stockholm, Sweden, and the International Sepsis Forum Award, Pasteur Institute, Paris, France (2014), etc. Professor N.V. Beloborodova wrote 210 papers, five books, 10 chapters and has edited four books.',institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"354260",title:"Ph.D.",name:"Tércio Elyan",middleName:"Azevedo",surname:"Azevedo Martins",slug:"tercio-elyan-azevedo-martins",fullName:"Tércio Elyan Azevedo Martins",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/354260/images/16241_n.jpg",biography:"Graduated in Pharmacy from the Federal University of Ceará with the modality in Industrial Pharmacy, Specialist in Production and Control of Medicines from the University of São Paulo (USP), Master in Pharmaceuticals and Medicines from the University of São Paulo (USP) and Doctor of Science in the program of Pharmaceuticals and Medicines by the University of São Paulo. Professor at Universidade Paulista (UNIP) in the areas of chemistry, cosmetology and trichology. Assistant Coordinator of the Higher Course in Aesthetic and Cosmetic Technology at Universidade Paulista Campus Chácara Santo Antônio. Experience in the Pharmacy area, with emphasis on Pharmacotechnics, Pharmaceutical Technology, Research and Development of Cosmetics, acting mainly on topics such as cosmetology, antioxidant activity, aesthetics, photoprotection, cyclodextrin and thermal analysis.",institutionString:null,institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"334285",title:"Ph.D. Student",name:"Sameer",middleName:"Kumar",surname:"Jagirdar",slug:"sameer-jagirdar",fullName:"Sameer Jagirdar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334285/images/14691_n.jpg",biography:"I\\'m a graduate student at the center for biosystems science and engineering at the Indian Institute of Science, Bangalore, India. I am interested in studying host-pathogen interactions at the biomaterial interface.",institutionString:null,institution:{name:"Indian Institute of Science Bangalore",country:{name:"India"}}},{id:"329795",title:"Dr.",name:"Mohd Aftab",middleName:"Aftab",surname:"Siddiqui",slug:"mohd-aftab-siddiqui",fullName:"Mohd Aftab Siddiqui",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329795/images/15648_n.jpg",biography:"Dr. Mohd Aftab Siddiqui is currently working as Assistant Professor in the Faculty of Pharmacy, Integral University, Lucknow for the last 6 years. He has completed his Doctor in Philosophy (Pharmacology) in 2020 from Integral University, Lucknow. He completed his Bachelor in Pharmacy in 2013 and Master in Pharmacy (Pharmacology) in 2015 from Integral University, Lucknow. He is the gold medalist in Bachelor and Master degree. He qualified GPAT -2013, GPAT -2014, and GPAT 2015. His area of research is Pharmacological screening of herbal drugs/ natural products in liver and cardiac diseases. He has guided many M. Pharm. research projects. He has many national and international publications.",institutionString:"Integral University",institution:null},{id:"255360",title:"Dr.",name:"Usama",middleName:null,surname:"Ahmad",slug:"usama-ahmad",fullName:"Usama Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255360/images/system/255360.png",biography:"Dr. Usama Ahmad holds a specialization in Pharmaceutics from Amity University, Lucknow, India. He received his Ph.D. degree from Integral University. Currently, he’s working as an Assistant Professor of Pharmaceutics in the Faculty of Pharmacy, Integral University. From 2013 to 2014 he worked on a research project funded by SERB-DST, Government of India. He has a rich publication record with more than 32 original articles published in reputed journals, 3 edited books, 5 book chapters, and a number of scientific articles published in ‘Ingredients South Asia Magazine’ and ‘QualPharma Magazine’. He is a member of the American Association for Cancer Research, International Association for the Study of Lung Cancer, and the British Society for Nanomedicine. Dr. Ahmad’s research focus is on the development of nanoformulations to facilitate the delivery of drugs that aim to provide practical solutions to current healthcare problems.",institutionString:"Integral University",institution:{name:"Integral University",country:{name:"India"}}},{id:"30568",title:"Prof.",name:"Madhu",middleName:null,surname:"Khullar",slug:"madhu-khullar",fullName:"Madhu Khullar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/30568/images/system/30568.jpg",biography:"Dr. Madhu Khullar is a Professor of Experimental Medicine and Biotechnology at the Post Graduate Institute of Medical Education and Research, Chandigarh, India. She completed her Post Doctorate in hypertension research at the Henry Ford Hospital, Detroit, USA in 1985. She is an editor and reviewer of several international journals, and a fellow and member of several cardiovascular research societies. Dr. Khullar has a keen research interest in genetics of hypertension, and is currently studying pharmacogenetics of hypertension.",institutionString:"Post Graduate Institute of Medical Education and Research",institution:{name:"Post Graduate Institute of Medical Education and Research",country:{name:"India"}}},{id:"223233",title:"Prof.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/223233/images/system/223233.png",biography:"Xianquan Zhan received his MD and Ph.D. in Preventive Medicine at West China University of Medical Sciences. He received his post-doctoral training in oncology and cancer proteomics at the Central South University, China, and the University of Tennessee Health Science Center (UTHSC), USA. He worked at UTHSC and the Cleveland Clinic in 2001–2012 and achieved the rank of associate professor at UTHSC. Currently, he is a full professor at Central South University and Shandong First Medical University, and an advisor to MS/PhD students and postdoctoral fellows. He is also a fellow of the Royal Society of Medicine and European Association for Predictive Preventive Personalized Medicine (EPMA), a national representative of EPMA, and a member of the American Society of Clinical Oncology (ASCO) and the American Association for the Advancement of Sciences (AAAS). He is also the editor in chief of International Journal of Chronic Diseases & Therapy, an associate editor of EPMA Journal, Frontiers in Endocrinology, and BMC Medical Genomics, and a guest editor of Mass Spectrometry Reviews, Frontiers in Endocrinology, EPMA Journal, and Oxidative Medicine and Cellular Longevity. He has published more than 148 articles, 28 book chapters, 6 books, and 2 US patents in the field of clinical proteomics and biomarkers.",institutionString:"Shandong First Medical University",institution:{name:"Affiliated Hospital of Shandong Academy of Medical Sciences",country:{name:"China"}}},{id:"297507",title:"Dr.",name:"Charles",middleName:"Elias",surname:"Assmann",slug:"charles-assmann",fullName:"Charles Assmann",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/297507/images/system/297507.jpg",biography:"Charles Elias Assmann is a biologist from Federal University of Santa Maria (UFSM, Brazil), who spent some time abroad at the Ludwig-Maximilians-Universität München (LMU, Germany). He has Masters Degree in Biochemistry (UFSM), and is currently a PhD student at Biochemistry at the Department of Biochemistry and Molecular Biology of the UFSM. His areas of expertise include: Biochemistry, Molecular Biology, Enzymology, Genetics and Toxicology. He is currently working on the following subjects: Aluminium toxicity, Neuroinflammation, Oxidative stress and Purinergic system. Since 2011 he has presented more than 80 abstracts in scientific proceedings of national and international meetings. Since 2014, he has published more than 20 peer reviewed papers (including 4 reviews, 3 in Portuguese) and 2 book chapters. He has also been a reviewer of international journals and ad hoc reviewer of scientific committees from Brazilian Universities.",institutionString:"Universidade Federal de Santa Maria",institution:{name:"Universidade Federal de Santa Maria",country:{name:"Brazil"}}},{id:"217850",title:"Dr.",name:"Margarete Dulce",middleName:null,surname:"Bagatini",slug:"margarete-dulce-bagatini",fullName:"Margarete Dulce Bagatini",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/217850/images/system/217850.jpeg",biography:"Dr. Margarete Dulce Bagatini is an associate professor at the Federal University of Fronteira Sul/Brazil. She has a degree in Pharmacy and a PhD in Biological Sciences: Toxicological Biochemistry. She is a member of the UFFS Research Advisory Committee\nand a member of the Biovitta Research Institute. She is currently:\nthe leader of the research group: Biological and Clinical Studies\nin Human Pathologies, professor of postgraduate program in\nBiochemistry at UFSC and postgraduate program in Science and Food Technology at\nUFFS. She has experience in the area of pharmacy and clinical analysis, acting mainly\non the following topics: oxidative stress, the purinergic system and human pathologies, being a reviewer of several international journals and books.",institutionString:"Universidade Federal da Fronteira Sul",institution:{name:"Universidade Federal da Fronteira Sul",country:{name:"Brazil"}}},{id:"226275",title:"Ph.D.",name:"Metin",middleName:null,surname:"Budak",slug:"metin-budak",fullName:"Metin Budak",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/226275/images/system/226275.jfif",biography:"Metin Budak, MSc, PhD is an Assistant Professor at Trakya University, Faculty of Medicine. He has been Head of the Molecular Research Lab at Prof. Mirko Tos Ear and Hearing Research Center since 2018. His specializations are biophysics, epigenetics, genetics, and methylation mechanisms. He has published around 25 peer-reviewed papers, 2 book chapters, and 28 abstracts. He is a member of the Clinical Research Ethics Committee and Quantification and Consideration Committee of Medicine Faculty. His research area is the role of methylation during gene transcription, chromatin packages DNA within the cell and DNA repair, replication, recombination, and gene transcription. His research focuses on how the cell overcomes chromatin structure and methylation to allow access to the underlying DNA and enable normal cellular function.",institutionString:"Trakya University",institution:{name:"Trakya University",country:{name:"Turkey"}}},{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",slug:"anca-pantea-stoian",fullName:"Anca Pantea Stoian",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",biography:"Anca Pantea Stoian is a specialist in diabetes, nutrition, and metabolic diseases as well as health food hygiene. She also has competency in general ultrasonography.\n\nShe is an associate professor in the Diabetes, Nutrition and Metabolic Diseases Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. She has been chief of the Hygiene Department, Faculty of Dentistry, at the same university since 2019. Her interests include micro and macrovascular complications in diabetes and new therapies. Her research activities focus on nutritional intervention in chronic pathology, as well as cardio-renal-metabolic risk assessment, and diabetes in cancer. She is currently engaged in developing new therapies and technological tools for screening, prevention, and patient education in diabetes. \n\nShe is a member of the European Association for the Study of Diabetes, Cardiometabolic Academy, CEDA, Romanian Society of Diabetes, Nutrition and Metabolic Diseases, Romanian Diabetes Federation, and Association for Renal Metabolic and Nutrition studies. She has authored or co-authored 160 papers in national and international peer-reviewed journals.",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",country:{name:"Romania"}}},{id:"279792",title:"Dr.",name:"João",middleName:null,surname:"Cotas",slug:"joao-cotas",fullName:"João Cotas",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/279792/images/system/279792.jpg",biography:"Graduate and master in Biology from the University of Coimbra.\n\nI am a research fellow at the Macroalgae Laboratory Unit, in the MARE-UC – Marine and Environmental Sciences Centre of the University of Coimbra. My principal function is the collection, extraction and purification of macroalgae compounds, chemical and bioactive characterization of the compounds and algae extracts and development of new methodologies in marine biotechnology area. \nI am associated in two projects: one consists on discovery of natural compounds for oncobiology. The other project is the about the natural compounds/products for agricultural area.\n\nPublications:\nCotas, J.; Figueirinha, A.; Pereira, L.; Batista, T. 2018. An analysis of the effects of salinity on Fucus ceranoides (Ochrophyta, Phaeophyceae), in the Mondego River (Portugal). Journal of Oceanology and Limnology. in press. DOI: 10.1007/s00343-019-8111-3",institutionString:"Faculty of Sciences and Technology of University of Coimbra",institution:null},{id:"279788",title:"Dr.",name:"Leonel",middleName:null,surname:"Pereira",slug:"leonel-pereira",fullName:"Leonel Pereira",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/279788/images/system/279788.jpg",biography:"Leonel Pereira has an undergraduate degree in Biology, a Ph.D. in Biology (specialty in Cell Biology), and a Habilitation degree in Biosciences (specialization in Biotechnology) from the Faculty of Science and Technology, University of Coimbra, Portugal, where he is currently a professor. In addition to teaching at this university, he is an integrated researcher at the Marine and Environmental Sciences Center (MARE), Portugal. His interests include marine biodiversity (algae), marine biotechnology (algae bioactive compounds), and marine ecology (environmental assessment). Since 2008, he has been the author and editor of the electronic publication MACOI – Portuguese Seaweeds Website (www.seaweeds.uc.pt). He is also a member of the editorial boards of several scientific journals. Dr. Pereira has edited or authored more than 20 books, 100 journal articles, and 45 book chapters. He has given more than 100 lectures and oral communications at various national and international scientific events. He is the coordinator of several national and international research projects. In 1998, he received the Francisco de Holanda Award (Honorable Mention) and, more recently, the Mar Rei D. Carlos award (18th edition). He is also a winner of the 2016 CHOICE Award for an outstanding academic title for his book Edible Seaweeds of the World. In 2020, Dr. Pereira received an Honorable Mention for the Impact of International Publications from the Web of Science",institutionString:"University of Coimbra",institution:{name:"University of Coimbra",country:{name:"Portugal"}}},{id:"61946",title:"Dr.",name:"Carol",middleName:null,surname:"Bernstein",slug:"carol-bernstein",fullName:"Carol Bernstein",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/61946/images/system/61946.jpg",biography:"Carol Bernstein received her PhD in Genetics from the University of California (Davis). She was a faculty member at the University of Arizona College of Medicine for 43 years, retiring in 2011. Her research interests focus on DNA damage and its underlying role in sex, aging and in the early steps of initiation and progression to cancer. In her research, she had used organisms including bacteriophage T4, Neurospora crassa, Schizosaccharomyces pombe and mice, as well as human cells and tissues. She authored or co-authored more than 140 scientific publications, including articles in major peer reviewed journals, book chapters, invited reviews and one book.",institutionString:"University of Arizona",institution:{name:"University of Arizona",country:{name:"United States of America"}}},{id:"182258",title:"Dr.",name:"Ademar",middleName:"Pereira",surname:"Serra",slug:"ademar-serra",fullName:"Ademar Serra",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/182258/images/system/182258.jpeg",biography:"Dr. Serra studied Agronomy on Universidade Federal de Mato Grosso do Sul (UFMS) (2005). He received master degree in Agronomy, Crop Science (Soil fertility and plant nutrition) (2007) by Universidade Federal da Grande Dourados (UFGD), and PhD in agronomy (Soil fertility and plant nutrition) (2011) from Universidade Federal da Grande Dourados / Escola Superior de Agricultura Luiz de Queiroz (UFGD/ESALQ-USP). Dr. Serra is currently working at Brazilian Agricultural Research Corporation (EMBRAPA). His research focus is on mineral nutrition of plants, crop science and soil science. Dr. Serra\\'s current projects are soil organic matter, soil phosphorus fractions, compositional nutrient diagnosis (CND) and isometric log ratio (ilr) transformation in compositional data analysis.",institutionString:"Brazilian Agricultural Research Corporation",institution:{name:"Brazilian Agricultural Research Corporation",country:{name:"Brazil"}}}]}},subseries:{item:{id:"26",type:"subseries",title:"Machine Learning and Data Mining",keywords:"Intelligent Systems, Machine Learning, Data Science, Data Mining, Artificial Intelligence",scope:"The scope of machine learning and data mining is immense and is growing every day. It has become a massive part of our daily lives, making predictions based on experience, making this a fascinating area that solves problems that otherwise would not be possible or easy to solve. This topic aims to encompass algorithms that learn from experience (supervised and unsupervised), improve their performance over time and enable machines to make data-driven decisions. It is not limited to any particular applications, but contributions are encouraged from all disciplines.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/26.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11422,editor:{id:"24555",title:"Dr.",name:"Marco Antonio",middleName:null,surname:"Aceves Fernandez",slug:"marco-antonio-aceves-fernandez",fullName:"Marco Antonio Aceves Fernandez",profilePictureURL:"https://mts.intechopen.com/storage/users/24555/images/system/24555.jpg",biography:"Dr. Marco Antonio Aceves Fernandez obtained his B.Sc. (Eng.) in Telematics from the Universidad de Colima, Mexico. He obtained both his M.Sc. and Ph.D. from the University of Liverpool, England, in the field of Intelligent Systems. 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