Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
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We wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
IntechOpen is proud to announce that 191 of our authors have made the Clarivate™ Highly Cited Researchers List for 2020, ranking them among the top 1% most-cited.
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Throughout the years, the list has named a total of 261 IntechOpen authors as Highly Cited. Of those researchers, 69 have been featured on the list multiple times.
\n\n\n\n
Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\n\n
We wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
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This book updates and reviews newly developed theories and technologies in human in vitro fertilization and focuses mainly on discussing its clinical practice. Areas covered include ovarian stimulation medicine and final ART outcomes, involving oocyte in vitro maturation, oocyte fertilization and failure treatment, blastocyst formation and implantation, as well as regulation of neuroendocrine embryo implantation. Thus, this book will add new knowledge for readers to improve their appreciation of ART.",isbn:"978-1-78985-306-3",printIsbn:"978-1-78985-305-6",pdfIsbn:"978-1-78985-639-2",doi:"10.5772/intechopen.73724",price:119,priceEur:129,priceUsd:155,slug:"embryology-theory-and-practice",numberOfPages:146,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"4620ebf60e92b453c7e4fde00cd94515",bookSignature:"Bin Wu and Huai L. Feng",publishedDate:"August 28th 2019",coverURL:"https://cdn.intechopen.com/books/images_new/6977.jpg",numberOfDownloads:12550,numberOfWosCitations:2,numberOfCrossrefCitations:6,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:12,numberOfDimensionsCitationsByBook:0,hasAltmetrics:1,numberOfTotalCitations:20,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"April 10th 2018",dateEndSecondStepPublish:"May 1st 2018",dateEndThirdStepPublish:"June 30th 2018",dateEndFourthStepPublish:"September 18th 2018",dateEndFifthStepPublish:"November 17th 2018",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"108807",title:"Ph.D.",name:"Bin",middleName:null,surname:"Wu",slug:"bin-wu",fullName:"Bin Wu",profilePictureURL:"https://mts.intechopen.com/storage/users/108807/images/system/108807.jfif",biography:"Bin Wu, Ph.D., HCLD is currently a scientific laboratory director at Arizona Center for Reproductive Endocrinology and Infertility, USA. He received his training in genetics and reproductive biology at the Northwest Agricultural University in China and Cornell University, New York and post-doctor training at University of Guelph, Canada. He was promoted as a professor at the Northwest Agricultural University. As an embryologist, he later joined in the Center for Human Reproduction in Chicago. Dr. Wu has membership for many professional associations, such as American Society for Reproductive Medicine; International Embryo Transfer Society; Society for the Study of Reproduction; American Association of Bioanalysts and European Society of Human Reproduction and Embryology. Also, he has obtained some significant research awards from these professional associations.",institutionString:"Arizona Center for Reproductive Endocrinology and Infertility",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"8",totalChapterViews:"0",totalEditedBooks:"5",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:{id:"251607",title:"Dr.",name:"Huai L.",middleName:null,surname:"Feng",slug:"huai-l.-feng",fullName:"Huai L. Feng",profilePictureURL:"https://mts.intechopen.com/storage/users/251607/images/7104_n.png",biography:"Dr. Feng is the Director of infertility/in vitro fertilization laboratories at New York –Presbyterian Health System, Affiliated Weill Medical College of Cornell University. He has served as Professor, Guest and Honorary Professors at number of other Universities and Institutions. Dr. Feng is an active member in many academic societies, such as ASRM, ASA, AAAS, and has served as an editor and Ad Hoc Reviewer for several reproduction-related journals, like Human Reproduction Update, Human Reproduction, and Fertility and Sterility. He has held over 25 research grants, published more than 200 research papers in peer-review scientific journals and has edited four books as editor in chief or in co-chief. He has also received more than thirty prizes and awards from professional committees and international organizations. He has presented over 100 invited lectures at conferences and workshop in international and domestic, and he has been selected as one of the leading scientists of the World 2005, IBC, Cambridge, UK and as an outstanding inspector from CAP in 2006, American Society for Reproductive Medicine (ASRM) 2014 Star Award.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:null},coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"1065",title:"Embryology",slug:"obstetrics-and-gynecology-embryology"}],chapters:[{id:"68249",title:"Introductory Chapter: New Theory and Technology in Early Clinical Embryogenesis",doi:"10.5772/intechopen.88331",slug:"introductory-chapter-new-theory-and-technology-in-early-clinical-embryogenesis",totalDownloads:989,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:null,signatures:"Bin Wu",downloadPdfUrl:"/chapter/pdf-download/68249",previewPdfUrl:"/chapter/pdf-preview/68249",authors:[{id:"108807",title:"Ph.D.",name:"Bin",surname:"Wu",slug:"bin-wu",fullName:"Bin Wu"}],corrections:null},{id:"65216",title:"Background Proteins in Human Chorionic Gonadotropin Pharmaceutical Formulations of Different Origins",doi:"10.5772/intechopen.82652",slug:"background-proteins-in-human-chorionic-gonadotropin-pharmaceutical-formulations-of-different-origins",totalDownloads:1085,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:1,abstract:"Gonadotropins, including human chorionic gonadotropin (hCG), have been used since and for several decades to treat infertility by ovarian stimulation. hCG is the most important protein for embryogenesis and embryo development and implantation in uterus upon fertilization of oocytes. The hCG used for in-vitro fertilization (IVF) is being extracted from urine of pregnant women, and it does inevitably contains other proteins secreted into urine. The presence of other proteins varies from batch to batch, and it can be significantly high. Due to the fact that many of the proteins identified in these formulations can trigger an allergic reaction, which, in turn, can affect the embryogenesis and prevent embryo implantation, it is very important to check the amount and type of contaminant proteins in pharmaceutical formulations. It was found that the total protein content varied from batch to batch, and a large number of contaminant urinary proteins were identified in all analyzed samples except for the recombinant product.",signatures:"Tanja Panić-Janković and Goran Mitulović",downloadPdfUrl:"/chapter/pdf-download/65216",previewPdfUrl:"/chapter/pdf-preview/65216",authors:[{id:"212804",title:"Dr.",name:"Goran",surname:"Mitulović",slug:"goran-mitulovic",fullName:"Goran Mitulović"},{id:"256238",title:"Dr.",name:"Tanja",surname:"Panić-Janković",slug:"tanja-panic-jankovic",fullName:"Tanja Panić-Janković"}],corrections:null},{id:"67832",title:"Clinical Application of In Vitro Maturation of Oocytes",doi:"10.5772/intechopen.87773",slug:"clinical-application-of-in-vitro-maturation-of-oocytes",totalDownloads:1309,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"In vitro maturation (IVM) is a technique used to induce immature oocytes collected in different periods of embryonic growth. The rates vary for immature oocytes collected from different clinical sources to potentially develop into embryos and achieve live birth. As an effective treatment method, IVM can be used to treat patients with polycystic ovary syndrome (PCOS), ovarian hyperresponsiveness, and hyporesponsiveness, as well as to preserve the fertility of cancer patients. This technology has been used worldwide for the birth of thousands of healthy babies. The improvement in clinical IVM technology mainly focuses on the IVM medium and the optimization of the culture environment and operation process. At present, with the improvement in the in vitro fertilization (IVF) efficiency and culture systems, a natural cycle or mild stimulation may be more suitable for women receiving IVF treatments. A new treatment option was proposed to combine natural cycle/mild stimulation IVF with IVM. In particular, the combination of mild stimulation IVF and IVM is not only expected to become a viable alternative to current standard treatments but may also become a potential option of first-line treatment.",signatures:"Xiaolin La, Jing Zhao and Zhihui Wang",downloadPdfUrl:"/chapter/pdf-download/67832",previewPdfUrl:"/chapter/pdf-preview/67832",authors:[{id:"291066",title:"Dr.",name:"Xiaolin",surname:"La",slug:"xiaolin-la",fullName:"Xiaolin La"},{id:"291067",title:"Dr.",name:"Jing",surname:"Zhao",slug:"jing-zhao",fullName:"Jing Zhao"},{id:"308602",title:"Dr.",name:"Zhihui",surname:"Wang",slug:"zhihui-wang",fullName:"Zhihui Wang"}],corrections:null},{id:"65172",title:"Oocyte Activation Failure: Physiological and Clinical Aspects",doi:"10.5772/intechopen.83488",slug:"oocyte-activation-failure-physiological-and-clinical-aspects",totalDownloads:1729,totalCrossrefCites:1,totalDimensionsCites:3,hasAltmetrics:1,abstract:"Despite successful treatment of infertility with assisted reproductive technology (ART), total fertilization failure (TFF) after in vitro fertilization (IVF) and even after intracytoplasmic sperm injection (ICSI) still occurs. In the current chapter, the incidence and etiology of TFF after ICSI are described. The literature on physiology of oocyte activation, electrical properties of gametes’ membranes, and ion currents is reviewed. Calcium oscillations play an essential role in fertilization, and calcium ions act as secondary messengers in different metabolic pathways and cellular processes during oocyte activation. The contribution of oocyte- and sperm-related causes of fertilization failure is discussed. Many studies on the physiology of fertilization in mammals have shown that oocyte activation is triggered by the sperm factor. Methods for artificial oocyte activation (AOA) try to bypass fertilization failure by influencing physiological processes that are crucial for successful fertilization. Activation can be induced with the use of electrical, mechanical, or chemical stimuli that elevate intracellular concentrations of calcium ions. Different AOA methods and their success and safety are presented.",signatures:"Nina Hojnik and Borut Kovačič",downloadPdfUrl:"/chapter/pdf-download/65172",previewPdfUrl:"/chapter/pdf-preview/65172",authors:[{id:"257108",title:"Prof.",name:"Borut",surname:"Kovačič",slug:"borut-kovacic",fullName:"Borut Kovačič"},{id:"257110",title:"MSc.",name:"Nina",surname:"Hojnik",slug:"nina-hojnik",fullName:"Nina Hojnik"}],corrections:null},{id:"64456",title:"Human Blastocyst Formation and Development",doi:"10.5772/intechopen.82095",slug:"human-blastocyst-formation-and-development",totalDownloads:1685,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:0,abstract:"The preimplantation period of human embryo development is remarkable and characterized by successive changes in terms of genetic control, physiology, and morphology of the embryo. Human preimplantation embryo development is characterized by the initial phase of embryo development, the phase before the embryo implantation process. In normal conditions, after fertilization, the embryo grows until the blastocyst stage. The blastocyst grows as the cells divide and the cavity expands, where it “hatches” from the zona pellucida to implant into the endometrium. Reprogramming and programming are continuous processes in the embryo that encompasses fusion of the egg and sperm pronuclei; epigenetic reprogramming and modification, an extensive wave of degradation of maternal transcripts, and activation of the nascent human embryonic genome and aneuploidy can occur in this stage. The embryo produces cytokines, growth factors, and receptors for endometrial signals in the apposition stage.",signatures:"Hilma Putri Lubis and Binarwan Halim",downloadPdfUrl:"/chapter/pdf-download/64456",previewPdfUrl:"/chapter/pdf-preview/64456",authors:[{id:"257685",title:"Dr.",name:"Hilma Putri",surname:"Lubis",slug:"hilma-putri-lubis",fullName:"Hilma Putri Lubis"},{id:"258506",title:"Dr.",name:"Binarwan",surname:"Halim",slug:"binarwan-halim",fullName:"Binarwan Halim"}],corrections:null},{id:"64133",title:"Bovine Embryonic Development to Implantation",doi:"10.5772/intechopen.80655",slug:"bovine-embryonic-development-to-implantation",totalDownloads:2053,totalCrossrefCites:2,totalDimensionsCites:2,hasAltmetrics:0,abstract:"Throughout this chapter, we will express the embryonic development from fertilization, commonly called conception, to the implantation. It is well documented that preimplantation is considered a critical period for embryo development in ruminants, in which high pregnancy loss occurs; in fact, several authors point out that 50–75% of blastocysts fail to implant. The high rate of implantation failure is one reason why pregnancy typically requires on average two ovulation cycles to achieve. Events involved in the embryo growth and survival are directly or indirectly related to cytokines, steroids, metabolites, and growth factors. When one of these compounds fails, it normally leads to the death of the embryo or fetus. As known, the period required for full development of a fetus in utero is referred to as gestation, and it is commonly subdivided into two distinct periods. The first 2 weeks of prenatal development are referred to as the pre-embryonic stage. By the end of the embryonic period, all of the organ systems are structured in rudimentary form, and the embryo shifts to the fetus from the ninth week of gestation until birth.",signatures:"Loide Valadão, Helena Moreira da Silva and Fernando Moreira da Silva",downloadPdfUrl:"/chapter/pdf-download/64133",previewPdfUrl:"/chapter/pdf-preview/64133",authors:[{id:"191057",title:"Prof.",name:"Fernando",surname:"Moreira Da Silva",slug:"fernando-moreira-da-silva",fullName:"Fernando Moreira Da Silva"},{id:"259013",title:"Dr.",name:"Helena",surname:"Moreira Da Silva",slug:"helena-moreira-da-silva",fullName:"Helena Moreira Da Silva"},{id:"262761",title:"Dr.",name:"Loide",surname:"Valadão",slug:"loide-valadao",fullName:"Loide Valadão"}],corrections:null},{id:"67826",title:"The Role of Neuroendocrine in Embryo Implantation",doi:"10.5772/intechopen.87863",slug:"the-role-of-neuroendocrine-in-embryo-implantation",totalDownloads:1046,totalCrossrefCites:2,totalDimensionsCites:2,hasAltmetrics:0,abstract:"Neuroendocrine integration, an integration of the nervous system and endocrine system as its name implies, plays a critical role in the reproductive system. However, less progress has been made in the particular effects of neuroendocrine on embryo implantation. Recently, some significant knowledges have been gained on the regulation of neuroendocrine in embryo implantation. This chapter will summarize the current state of knowledges about the impaction of neuroendocrine on embryo implantation and discuss potential strategy to get higher pregnancy rate and to reduce recurrent implantation failure (RIF) possibility through modulating the neuroendocrine systems.",signatures:"Fenting Liu and Rong Li",downloadPdfUrl:"/chapter/pdf-download/67826",previewPdfUrl:"/chapter/pdf-preview/67826",authors:[{id:"307568",title:"Dr.",name:"Rong",surname:"Li",slug:"rong-li",fullName:"Rong Li"},{id:"307576",title:"Dr.",name:"Fen-Ting",surname:"Liu",slug:"fen-ting-liu",fullName:"Fen-Ting Liu"}],corrections:null},{id:"63808",title:"The Present and Future of Embryo Cryopreservation",doi:"10.5772/intechopen.80587",slug:"the-present-and-future-of-embryo-cryopreservation",totalDownloads:1557,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Embryo freezing technologies have widely been used in human IVF practice and in animal industry. In this chapter, we will review the development of embryo freezing technology and the application of the method, which will concentrate on discussion of the arguments in favor of and against freezing, as well as the latest results of success rates, comparing them with the other basic assisted reproductive technologies methods. Then, we will present our viewpoint for the future application of embryo freezing methods and their place in reproductive medicine. The analysis of facts and suggestions should enable researchers to rethink the position of cryobiology in reproductive medicine. It should be considered that the method of cryopreservation is not only a technology for storing embryos but also a method of embryo treatment that can potentially improve the success rates in infertile couples. There is also a theory that describes the “treatment” effect of freezing an embryo, which may explain the higher success rates of frozen embryo transfer (FET) compared to fresh embryo transfer (ET). The authors of the “Theory about the Embryo-Cryo treatment” believe that freezing and thawing could activate endogenous survival and repair mechanisms in preimplantation embryos.",signatures:"Iavor K. Vladimirov, Desislava Tacheva and Vladislav Dobrinov",downloadPdfUrl:"/chapter/pdf-download/63808",previewPdfUrl:"/chapter/pdf-preview/63808",authors:[{id:"253947",title:"Dr.",name:"Iavor K.",surname:"Vladimirov",slug:"iavor-k.-vladimirov",fullName:"Iavor K. Vladimirov"},{id:"254692",title:"Dr.",name:"Desislava",surname:"Tacheva",slug:"desislava-tacheva",fullName:"Desislava Tacheva"},{id:"254693",title:"MSc.",name:"Vladislav",surname:"Dobrinov",slug:"vladislav-dobrinov",fullName:"Vladislav Dobrinov"}],corrections:null},{id:"68013",title:"Effect of Assisted Reproductive Technology (ART) on Babies Born: Compared by IVF Laboratories of Two Countries",doi:"10.5772/intechopen.87842",slug:"effect-of-assisted-reproductive-technology-art-on-babies-born-compared-by-ivf-laboratories-of-two-co",totalDownloads:1100,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Assisted reproductive technology (ART) has been widely used for infertility treatment, but many people have concern about their baby’s health. The objective of this chapter is to provide some detailed data about the effect of ART on human birth babies by analyzing the data from in vitro fertilization (IVF) centers in two countries. All recent records related to a baby’s birth including mother’s age, gestational days, baby’s sex, and birth weight data were collected and analyzed according to fresh or frozen embryo transfer procedure. Normal delivery data without ART were used as control. The result showed that ART patient age is significantly older than non-IVF women; the gestation of fresh and frozen embryo transfer is the same as normal spontaneous conception gestation days, but women pregnant with multiple gestations have shorter gestational period and early birth rate as well as low birth weight; and there is no significant difference in the baby’s weight between ART singleton babies and normal conception babies, but male babies weight is more than female babies, and multiple gestation’s birth weights are significantly lower than singletons, while frozen embryo transfer babies have significantly heavier birth weight than fresh embryo transfer. Also, the frozen embryo transfer technique may significantly decrease premature birth rate. Thus, frozen embryo transfer may be recommended as a health strategy in ART.",signatures:"Linda Wu, Jinzhou Qin, Dikai Zhang, Minqi Zhang, Suzhen Lu, Jennifer Howell, Timothy J. 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\r\n\tNext-generation textiles represent an exciting and interesting topic within the textiles sector. They are an intersection set between life science (for example medicine, microbiology, and comfort or strain) and technical applications (textile chemistry, engineering, and testing and certification). Developments in one of these areas affect the other one; for example, the invention of superabsorbent and gel-forming materials affected the production of a new type of baby diapers. Next-generation textiles can also be considered an important part of technical textiles, being used for different purposes such as chemical and biohazard protection. They present an important aspect from an economic point of view and the necessity for their production has been increasing; for example, a huge necessity for smart medical textiles comes from the increase of the elderly population in developed countries. In the last few decades, the rapid development of command cotton fabrics also occurred. This affects all textile sectors, for example, biodegradable fibers for implantations, three-dimension spacer fabrics, and reduction of bacterial growth by using silver ion-based textiles finishing. In this and other ways, the fields concerning the next-generation textiles have been growing rapidly and are becoming a more complex area to understand.
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\n\t\t\t
1. Introduction
\n\t\t\t
The obtained results of a supersonic perfect gas flow presented in (Anderson, 1982, 1988& Ryhming, 1984), are valid under some assumptions. One of the assumptions is that the gas is regarded as a calorically perfect, i. e., the specific heats C\n\t\t\t\t\n\t\t\t\t\tP\n\t\t\t\t is constant and does not depend on the temperature, which is not valid in the real case when the temperature increases (Zebbiche & Youbi, 2005b, 2006, Zebbiche, 2010a, 2010b). The aim of this research is to develop a mathematical model of the gas flow by adding the variation effect of C\n\t\t\t\t\n\t\t\t\t\tP\n\t\t\t\t and γ with the temperature. In this case, the gas is named by calorically imperfect gas or gas at high temperature. There are tables for air (Peterson & Hill, 1965) for example) that contain the values of C\n\t\t\t\t\n\t\t\t\t\tP\n\t\t\t\t and γ versus the temperature in interval 55 K to 3550 K. We carried out a polynomial interpolation of these values in order to find an analytical form for the function C\n\t\t\t\t\n\t\t\t\t\tP\n\t\t\t\t\n\t\t\t\t(T).\n\t\t\t
\n\t\t\t
The presented mathematical relations are valid in the general case independently of the interpolation form and the substance, but the results are illustrated by a polynomial interpolation of the 9th degree. The obtained mathematical relations are in the form of nonlinear algebraic equations, and so analytical integration was impossible. Thus, our interest is directed towards to the determination of numerical solutions. The dichotomy method for the solution of the nonlinear algebraic equations is used; the Simpson’s algorithm (Démidovitch & Maron, 1987& Zebbiche & Youbi, 2006, Zebbiche, 2010a, 2010b) for numerical integration of the found functions is applied. The integrated functions have high gradients of the interval extremity, where the Simpson’s algorithm requires a very high discretization to have a suitable precision. The solution of this problem is made by introduction of a condensation procedure in order to refine the points at the place where there is high gradient. The Robert’s condensation formula presented in (Fletcher, 1988) was chosen. The application for the air in the supersonic field is limited by the threshold of the molecules dissociation. The comparison is made with the calorically perfect gas model.
\n\t\t\t
The problem encounters in the aeronautical experiments where the use of the nozzle designed on the basis of the perfect gas assumption, degrades the performances. If during the experiment measurements are carried out it will be found that measured parameters are differed from the calculated, especially for the high stagnation temperature. Several reasons are responsible for this deviation. Our flow is regarded as perfect, permanent and non-rotational. The gas is regarded as calorically imperfect and thermally perfect. The theory of perfect gas does not take account of this temperature.
\n\t\t\t
To determine the application limits of the perfect gas model, the error given by this model is compared with our results.
\n\t\t
\n\t\t
\n\t\t\t
2. Mathematical formulation
\n\t\t\t
The development is based on the use of the conservation equations in differential form. We assume that the state equation of perfect gas (P=ρRT) remains valid, with R=287.102 J/(kg K). For the adiabatic flow, the temperature and the density of a perfect gas are related by the following differential equation (Moran, 2007& Oosthuisen & Carscallen, 1997& Zuker & Bilbarz, 2002, Zebbiche, 2010a, 2010b).
Using relationship between C\n\t\t\t\t\n\t\t\t\t\tP\n\t\t\t\t and γ [C\n\t\t\t\t\n\t\t\t\t\tP\n\t\t\t\t\n\t\t\t\t=γR/(γ-1)], the equation (1) can be written at the following form:
Equation (5) proves that the relation of speed of sound of perfect gas remains always valid for the model at high temperature, but it is necessary to take into account the variation of the ratio γ(T).\n\t\t\t
\n\t\t\t
The equation of the energy conservation in differential form (Anderson, 1988& Moran, 2007) is written as:
The integration between the stagnation state (V\n\t\t\t\t\n\t\t\t\t\t0\n\t\t\t\t\n\t\t\t\t≈ 0, T\n\t\t\t\t\n\t\t\t\t\t0\n\t\t\t\t) and supersonic state (V, T) gives:
The density ratio relative to the temperature T\n\t\t\t\t\n\t\t\t\t\t0\n\t\t\t\t can be obtained by integration of the function (13) between the stagnation state (ρ\n\t\t\t\t\n\t\t\t\t\t0\n\t\t\t\t\n\t\t\t\t,T\n\t\t\t\t\n\t\t\t\t\t0\n\t\t\t\t) and the concerned supersonic state (ρ,T):
The integration of equation (17) between the critical state (A\n\t\t\t\t\n\t\t\t\t\t*\n\t\t\t\t\n\t\t\t\t, T\n\t\t\t\t\n\t\t\t\t\t*\n\t\t\t\t) and the supersonic state (A, T) gives the cross-section areas ratio: *
To find parameters ρ and A, the integrals of functions F\n\t\t\t\t\n\t\t\t\t\tρ\n\t\t\t\t\n\t\t\t\t(T) and F\n\t\t\t\t\n\t\t\t\t\tA\n\t\t\t\t\n\t\t\t\t(T) should be found. As the analytical procedure is impossible, our interest is directed towards the numerical calculation. All parameters M, ρ and A depend on the temperature.\n\t\t\t
As the mass flow rate through the throat is constant, we can calculate it at the throat. In this section, we have ρ=ρ\n\t\t\t\t\n\t\t\t\t\t*\n\t\t\t\t\n\t\t\t\t, a=a\n\t\t\t\t\n\t\t\t\t\t*\n\t\t\t\t, M=1, θ=0 and A=A\n\t\t\t\t\n\t\t\t\t\t*\n\t\t\t\t\n\t\t\t\t. Therefore, the relation (20) is reduced to:
The parameters T, P, ρ and A for the perfect gas are connected explicitly with the Mach number, which is the basic variable for that model. For our model, the basic variable is the temperature because of the implicit equation (10) connecting M and T, where the reverse analytical expression does not exist.
\n\t\t
\n\t\t
\n\t\t\t
3. Calculation procedure
\n\t\t\t
In the first case, one presents the table of variation of CP and γ versus the temperature for air (Peterson & Hill, 1965, Zebbiche 2010a, 2010b). The values are presented in the table 1.
\n\t\t\t
\n\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\t\t\t
T (K)
\n\t\t\t\t\t\t
CP(J/(KgK)
\n\t\t\t\t\t\t
γ(T)
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
T (K)
\n\t\t\t\t\t\t
CP (J/(Kg K)
\n\t\t\t\t\t\t
γ(T)
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
T (K)
\n\t\t\t\t\t\t
CP J/(Kg K)
\n\t\t\t\t\t\t
γ(T)
\n\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\t\t\t
55.538
\n\t\t\t\t\t\t
1001.104
\n\t\t\t\t\t\t
1.402
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
833.316
\n\t\t\t\t\t\t
1107.192
\n\t\t\t\t\t\t
1.350
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
2111.094
\n\t\t\t\t\t\t
1256.813
\n\t\t\t\t\t\t
1.296
\n\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\t\t\t
.
\n\t\t\t\t\t\t
.
\n\t\t\t\t\t\t
.
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
888.872
\n\t\t\t\t\t\t
1119.078
\n\t\t\t\t\t\t
1.345
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
2222.205
\n\t\t\t\t\t\t
1263.410
\n\t\t\t\t\t\t
1.294
\n\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\t\t\t
222.205
\n\t\t\t\t\t\t
1001.101
\n\t\t\t\t\t\t
1.402
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
944.427
\n\t\t\t\t\t\t
1131.314
\n\t\t\t\t\t\t
1.340
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
2333.316
\n\t\t\t\t\t\t
1270.097
\n\t\t\t\t\t\t
1.292
\n\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\t\t\t
277.761
\n\t\t\t\t\t\t
1002.885
\n\t\t\t\t\t\t
1.401
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
999.983
\n\t\t\t\t\t\t
1141.365
\n\t\t\t\t\t\t
1.336
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
2444.427
\n\t\t\t\t\t\t
1273.476
\n\t\t\t\t\t\t
1.291
\n\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\t\t\t
305.538
\n\t\t\t\t\t\t
1004.675
\n\t\t\t\t\t\t
1.400
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
1055.538
\n\t\t\t\t\t\t
1151.658
\n\t\t\t\t\t\t
1.332
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
2555.538
\n\t\t\t\t\t\t
1276.877
\n\t\t\t\t\t\t
1.290
\n\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\t\t\t
333.316
\n\t\t\t\t\t\t
1006.473
\n\t\t\t\t\t\t
1.399
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
1111.094
\n\t\t\t\t\t\t
1162.202
\n\t\t\t\t\t\t
1.328
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
2666.650
\n\t\t\t\t\t\t
1283.751
\n\t\t\t\t\t\t
1.288
\n\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\t\t\t
361.094
\n\t\t\t\t\t\t
1008.281
\n\t\t\t\t\t\t
1.398
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
1166.650
\n\t\t\t\t\t\t
1170.280
\n\t\t\t\t\t\t
1.325
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
2777.761
\n\t\t\t\t\t\t
1287.224
\n\t\t\t\t\t\t
1.287
\n\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\t\t\t
388.872
\n\t\t\t\t\t\t
1011.923
\n\t\t\t\t\t\t
1.396
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
1222.205
\n\t\t\t\t\t\t
1178.509
\n\t\t\t\t\t\t
1.322
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
2888.872
\n\t\t\t\t\t\t
1290.721
\n\t\t\t\t\t\t
1.286
\n\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\t\t\t
416.650
\n\t\t\t\t\t\t
1015.603
\n\t\t\t\t\t\t
1.394
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
1277.761
\n\t\t\t\t\t\t
1186.893
\n\t\t\t\t\t\t
1.319
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
2999.983
\n\t\t\t\t\t\t
1294.242
\n\t\t\t\t\t\t
1.285
\n\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\t\t\t
444.427
\n\t\t\t\t\t\t
1019.320
\n\t\t\t\t\t\t
1.392
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
1333.316
\n\t\t\t\t\t\t
1192.570
\n\t\t\t\t\t\t
1.317
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
3111.094
\n\t\t\t\t\t\t
1297.789
\n\t\t\t\t\t\t
1.284
\n\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\t\t\t
499.983
\n\t\t\t\t\t\t
1028.781
\n\t\t\t\t\t\t
1.387
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
1444.427
\n\t\t\t\t\t\t
1204.142
\n\t\t\t\t\t\t
1.313
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
3222.205
\n\t\t\t\t\t\t
1301.360
\n\t\t\t\t\t\t
1.283
\n\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\t\t\t
555.538
\n\t\t\t\t\t\t
1054.563
\n\t\t\t\t\t\t
1.374
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
1555.538
\n\t\t\t\t\t\t
1216.014
\n\t\t\t\t\t\t
1.309
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
3333.316
\n\t\t\t\t\t\t
1304.957
\n\t\t\t\t\t\t
1.282
\n\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\t\t\t
611.094
\n\t\t\t\t\t\t
1054.563
\n\t\t\t\t\t\t
1.370
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
1666.650
\n\t\t\t\t\t\t
1225.121
\n\t\t\t\t\t\t
1.306
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
3444.427
\n\t\t\t\t\t\t
1304.957
\n\t\t\t\t\t\t
1.282
\n\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\t\t\t
666.650
\n\t\t\t\t\t\t
1067.077
\n\t\t\t\t\t\t
1.368
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
1777.761
\n\t\t\t\t\t\t
1234.409
\n\t\t\t\t\t\t
1.303
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
3555.538
\n\t\t\t\t\t\t
1308.580
\n\t\t\t\t\t\t
1.281
\n\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\t\t\t
722.205
\n\t\t\t\t\t\t
1080.005
\n\t\t\t\t\t\t
1.362
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
1888.872
\n\t\t\t\t\t\t
1243.883
\n\t\t\t\t\t\t
1.300
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\t\t\t
777.761
\n\t\t\t\t\t\t
1093.370
\n\t\t\t\t\t\t
1.356
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
1999.983
\n\t\t\t\t\t\t
1250.305
\n\t\t\t\t\t\t
1.298
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\t
Table 1.
Variation of C\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tP\n\t\t\t\t\t\t\n\t\t\t\t\t\t(T) and γ(T) versus the temperature for air.
\n\t\t\t
For a perfect gas, the γ and C\n\t\t\t\t\n\t\t\t\t\tP\n\t\t\t\t values are equal to γ=1.402 and C\n\t\t\t\t\n\t\t\t\t\tP\n\t\t\t\t\n\t\t\t\t=1001.28932 J/(kgK) (Oosthuisen & Carscallen, 1997, Moran, 2007& Zuker & Bilbarz, 2002).. The interpolation of the C\n\t\t\t\t\n\t\t\t\t\tP\n\t\t\t\t values according to the temperature is presented by relation (23) in the form of Horner scheme to minimize the mathematical operations number (Zebbiche, 2010a, 2010b):
The interpolation (a\n\t\t\t\t\n\t\t\t\t\ti\n\t\t\t\t\n\t\t\t\ti=1, 2, …, 10) of constants are illustrated in table 2.
\n\t\t\t
\n\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\t\t\t
I
\n\t\t\t\t\t\t
ai
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
I
\n\t\t\t\t\t\t
ai
\n\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\t\t\t
1
\n\t\t\t\t\t\t
1001.1058
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
6
\n\t\t\t\t\t\t
3.069773 10-12
\n\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\t\t\t
2
\n\t\t\t\t\t\t
0.04066128
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
7
\n\t\t\t\t\t\t
-1.350935 10-15
\n\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\t\t\t
3
\n\t\t\t\t\t\t
-0.000633769
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
8
\n\t\t\t\t\t\t
3.472262 10-19
\n\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\t\t\t
4
\n\t\t\t\t\t\t
2.747475 10-6
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
9
\n\t\t\t\t\t\t
-4.846753 10-23
\n\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\t\t\t
5
\n\t\t\t\t\t\t
-4.033845 10-9
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
10
\n\t\t\t\t\t\t
2.841187 10-27
\n\t\t\t\t\t
\n\t\t\t\t
Table 2.
Coefficients of the polynomial C\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tP\n\t\t\t\t\t\t\n\t\t\t\t\t\t(T).
\n\t\t\t
A relationship (23) gives undulated dependence for temperature approximately low than\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\tT \n\t\t\t\t\t\t\t\t¯\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t=\n\t\t\t\t\t\t\t240K\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t. So for this field, the table value (Peterson & Hill, 1965), was taken
for\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tT\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t≤\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\tT\n\t\t\t\t\t\t\t\t¯\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t, we have \n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\tC\n\t\t\t\t\t\t\t\tP\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t(\n\t\t\t\t\t\t\tT\n\t\t\t\t\t\t\t)\n\t\t\t\t\t\t\t=\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\tC\n\t\t\t\t\t\t\t\t\t¯\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\tP\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\tfor\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tT\n\t\t\t\t\t\t\t>\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\tT\n\t\t\t\t\t\t\t\t¯\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t, relation (23) is used.
\n\t\t\t
The selected interpolation gives an error less than ε=10\n\t\t\t\t\n\t\t\t\t\t-3\n\t\t\t\t between the table and interpolated values.
\n\t\t\t
Once the interpolation is made, we determine the function H(T) of the relation (8), by integrating the function C\n\t\t\t\t\n\t\t\t\t\tP\n\t\t\t\t\n\t\t\t\t(T) in the interval [T, T\n\t\t\t\t\n\t\t\t\t\t0\n\t\t\t\t]. Then, H(T) is a function with a parameter T\n\t\t\t\t\n\t\t\t\t\t0\n\t\t\t\t\n\t\t\t\tand it is defined when T≤T\n\t\t\t\t\n\t\t\t\t\t0\n\t\t\t\t\n\t\t\t\t.\n\t\t\t
\n\t\t\t
Substituting the relation (23) in (8) and writing the integration results in the form of Horner scheme, the following expression for enthalpy is obtained
Variation of function F\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tρ\n\t\t\t\t\t\t\n\t\t\t\t\t\t(T) in the interval [T\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tS\n\t\t\t\t\t\t\n\t\t\t\t\t\t,T\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t0\n\t\t\t\t\t\t] versusT\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t0\n\t\t\t\t\t\t.
\n\t\t\t
Taking into account the correction made to the function C\n\t\t\t\t\n\t\t\t\t\tP\n\t\t\t\t\n\t\t\t\t(T), the function H(T) has the following form:
For\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\tT\n\t\t\t\t\t\t\t\t0\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t>\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\tT\n\t\t\t\t\t\t\t\t¯\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t,we have two cases:\n\t\t\t
The determination of the ratios (14) and (19) require the numerical integration of F\n\t\t\t\t\n\t\t\t\t\tρ\n\t\t\t\t\n\t\t\t\t(T) and F\n\t\t\t\t\n\t\t\t\t\tA\n\t\t\t\t\n\t\t\t\t(T) in the intervals [T, T\n\t\t\t\t\n\t\t\t\t\t0\n\t\t\t\t\n\t\t\t\t] and [T, T\n\t\t\t\t\n\t\t\t\t\t*\n\t\t\t\t\n\t\t\t\t] respectively. We carried out preliminary calculation of these functions (Figs. 1, 2) to see their variations and to choice the integration method.
\n\t\t\t
Figure 2.
Variation of the function F\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tA\n\t\t\t\t\t\t\n\t\t\t\t\t\t(T) in the interval [T\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tS\n\t\t\t\t\t\t\n\t\t\t\t\t\t,T\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t*\n\t\t\t\t\t\t] versus T\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t0\n\t\t\t\t\t\t\n\t\t\t\t\t
\n\t\t\t
Due to high gradient at the left extremity of the interval, the integration with a constant step requires a very small step. The tracing of the functions is selected for T\n\t\t\t\t\n\t\t\t\t\t0\n\t\t\t\t=500 K (low temperature) and M\n\t\t\t\t\n\t\t\t\t\tS\n\t\t\t\t=6.00 (extreme supersonic) for a good representation in these ends. In this case, we obtain T\n\t\t\t\t\n\t\t\t\t\t*\n\t\t\t\t=418.34 K and T\n\t\t\t\t\n\t\t\t\t\tS\n\t\t\t\t=61.07 K. the two functions presents a very large derivative at temperature T\n\t\t\t\t\n\t\t\t\t\tS\n\t\t\t\t\n\t\t\t\t.\n\t\t\t
\n\t\t\t
A Condensation of nodes is then necessary in the vicinity of T\n\t\t\t\t\n\t\t\t\t\tS\n\t\t\t\t for the two functions. The goal of this condensation is to calculate the value of integral with a high precision in a reduced time by minimizing the nodes number. The Simpson’s integration method (Démidovitch & Maron, 1987& Zebbiche & Youbi, 2006) was chosen. The chosen condensation function has the following form (Zebbiche & Youbi, 2005a):
The temperature T\n\t\t\t\t\n\t\t\t\t\tD\n\t\t\t\t is equal to T\n\t\t\t\t\n\t\t\t\t\t0\n\t\t\t\t for F\n\t\t\t\t\n\t\t\t\t\tρ\n\t\t\t\t\n\t\t\t\t(T), and equal to T\n\t\t\t\t\n\t\t\t\t\t*\n\t\t\t\t for F\n\t\t\t\t\n\t\t\t\t\tA\n\t\t\t\t\n\t\t\t\t(T). The temperature T\n\t\t\t\t\n\t\t\t\t\tG\n\t\t\t\t is equal to T\n\t\t\t\t\n\t\t\t\t\t*\n\t\t\t\t for the critical parameter, and equal to T\n\t\t\t\t\n\t\t\t\t\tS\n\t\t\t\t for the supersonic parameter. Taking a value b\n\t\t\t\t\t1\n\t\t\t\t near zero (b\n\t\t\t\t\t1\n\t\t\t\t=0.1, for example) and b\n\t\t\t\t\t2\n\t\t\t\t=2.0, it can condense the nodes towards left edge T\n\t\t\t\t\n\t\t\t\t\tS\n\t\t\t\t of the interval, see figure 3.
\n\t\t\t
Figure 3.
Presentation of the condensation of nodes
3.1. Critical parameters
The stagnation state is given by M=0. Then, the critical parameters correspond to M=1.00, for example at the throat of a supersonic nozzle, summarize by:
\n\t\t\t
When M=1.00 we have T=T\n\t\t\t\t\n\t\t\t\t\t*\n\t\t\t\t. These conditions in the relation (10), we obtain:
The resolution of equation (29) is made by the use of the dichotomy algorithm (Démidovitch & Maron, 1987& Zebbiche & Youbi, 2006), with T\n\t\t\t\t\n\t\t\t\t\t*\n\t\t\t\t\n\t\t\t\t<T\n\t\t\t\t\n\t\t\t\t\t0\n\t\t\t\t. It can choose the interval [T\n\t\t\t\t\n\t\t\t\t\t1\n\t\t\t\t\n\t\t\t\t,T\n\t\t\t\t\n\t\t\t\t\t2\n\t\t\t\t\n\t\t\t\t] containing T\n\t\t\t\t\n\t\t\t\t\t*\n\t\t\t\t by T\n\t\t\t\t\n\t\t\t\t\t1\n\t\t\t\t\n\t\t\t\t=0 K and T\n\t\t\t\t\n\t\t\t\t\t2\n\t\t\t\t\n\t\t\t\t=T\n\t\t\t\t\n\t\t\t\t\t0\n\t\t\t\t. The value T\n\t\t\t\t\n\t\t\t\t\t*\n\t\t\t\t can be given with a precision ε if the interval of subdivision number K is satisfied by the following condition:
If ε=10-8 is taken, the number K cannot exceed 39. Consequently, the temperature ratio T\n\t\t\t\t\n\t\t\t\t\t*\n\t\t\t\t\n\t\t\t\t/T\n\t\t\t\t\n\t\t\t\t\t0\n\t\t\t\t can be calculated.
\n\t\t\t
Taking T=T\n\t\t\t\t\n\t\t\t\t\t*\n\t\t\t\t and ρ=ρ\n\t\t\t\t\n\t\t\t\t\t*\n\t\t\t\t in the relation (14) and integrating the function F\n\t\t\t\t\n\t\t\t\t\tρ\n\t\t\t\t\n\t\t\t\t(T) by using the Simpson’s formula with condensation of nodes towards the left end, the critical density ratio is obtained.
\n\t\t\t
The critical ratios of the pressures and the sound velocity can be calculated by using the relations (15) and (22) respectively, by replacing T=T\n\t\t\t\t\n\t\t\t\t\t*\n\t\t\t\t\n\t\t\t\t, ρ=ρ\n\t\t\t\t\n\t\t\t\t\t*\n\t\t\t\t\n\t\t\t\t, P=P\n\t\t\t\t\n\t\t\t\t\t*\n\t\t\t\t and a=a\n\t\t\t\t\n\t\t\t\t\t*\n\t\t\t\t\n\t\t\t\t,\n\t\t\t
\n\t\t\t
\n\t\t\t\t
3.2. Parameters for a supersonic Mach number
\n\t\t\t\t
For a given supersonic cross-section, the parameters ρ=ρ\n\t\t\t\t\t\n\t\t\t\t\t\tS\n\t\t\t\t\t\n\t\t\t\t\t, P=P\n\t\t\t\t\t\n\t\t\t\t\t\tS\n\t\t\t\t\t\n\t\t\t\t\t, A=A\n\t\t\t\t\t\n\t\t\t\t\t\tS\n\t\t\t\t\t\n\t\t\t\t\t, and T=T\n\t\t\t\t\t\n\t\t\t\t\t\tS\n\t\t\t\t\t can be determined according to the Mach number M=M\n\t\t\t\t\t\n\t\t\t\t\t\tS\n\t\t\t\t\t. Replacing T=T\n\t\t\t\t\t\n\t\t\t\t\t\tS\n\t\t\t\t\t and M=M\n\t\t\t\t\t\n\t\t\t\t\t\tS\n\t\t\t\t\t in relation (10) gives
The determination of T\n\t\t\t\t\t\n\t\t\t\t\t\tS\n\t\t\t\t\t of equation (31) is done always by the dichotomy algorithm, excepting T\n\t\t\t\t\t\n\t\t\t\t\t\tS\n\t\t\t\t\t\n\t\t\t\t\t<T\n\t\t\t\t\t\n\t\t\t\t\t\t*\n\t\t\t\t\t\n\t\t\t\t\t. We can take the interval [T\n\t\t\t\t\t\n\t\t\t\t\t\t1\n\t\t\t\t\t\n\t\t\t\t\t,T\n\t\t\t\t\t\n\t\t\t\t\t\t2\n\t\t\t\t\t\n\t\t\t\t\t] containing T\n\t\t\t\t\t\n\t\t\t\t\t\tS\n\t\t\t\t\t, by (T\n\t\t\t\t\t\n\t\t\t\t\t\t1\n\t\t\t\t\t=0 K, and T\n\t\t\t\t\t\n\t\t\t\t\t\t2\n\t\t\t\t\t\n\t\t\t\t\t=T\n\t\t\t\t\t\n\t\t\t\t\t\t*.\n\t\t\t\t\t\n\t\t\t\t
\n\t\t\t\t
Replacing T=T\n\t\t\t\t\t\n\t\t\t\t\t\tS\n\t\t\t\t\t and ρ=ρ\n\t\t\t\t\t\n\t\t\t\t\t\tS\n\t\t\t\t\t in relation (14) and integrating the function F\n\t\t\t\t\t\n\t\t\t\t\t\tρ\n\t\t\t\t\t\n\t\t\t\t\t(T) by using the Simpson’s method with condensation of nodes towards the left end, the density ratio can be obtained.
\n\t\t\t\t
The ratios of pressures, speed of sound and the sections corresponding to M=M\n\t\t\t\t\t\n\t\t\t\t\t\tS\n\t\t\t\t\t can be calculated respectively by using the relations (15), (22) and (19) by replacing T=T\n\t\t\t\t\t\n\t\t\t\t\t\tS\n\t\t\t\t\t, ρ=ρ\n\t\t\t\t\t\n\t\t\t\t\t\tS\n\t\t\t\t\t\n\t\t\t\t\t, P=P\n\t\t\t\t\t\n\t\t\t\t\t\tS\n\t\t\t\t\t, a=a\n\t\t\t\t\t\n\t\t\t\t\t\tS\n\t\t\t\t\t and A=A\n\t\t\t\t\t\n\t\t\t\t\t\tS\n\t\t\t\t\t\n\t\t\t\t\t.\n\t\t\t\t
\n\t\t\t\t
The integration results of the ratios ρ\n\t\t\t\t\t\n\t\t\t\t\t\t*\n\t\t\t\t\t\n\t\t\t\t\t/ ρ\n\t\t\t\t\t\n\t\t\t\t\t\t0\n\t\t\t\t\t\n\t\t\t\t\t, ρ\n\t\t\t\t\t\n\t\t\t\t\t\tS\n\t\t\t\t\t\n\t\t\t\t\t/ρ\n\t\t\t\t\t\n\t\t\t\t\t\t0\n\t\t\t\t\t and A\n\t\t\t\t\t\n\t\t\t\t\t\tS\n\t\t\t\t\t\n\t\t\t\t\t/A\n\t\t\t\t\t\n\t\t\t\t\t\t*\n\t\t\t\t\t primarily depend on the values of N, b\n\t\t\t\t\t\n\t\t\t\t\t\t1\n\t\t\t\t\t and b\n\t\t\t\t\t\n\t\t\t\t\t\t2\n\t\t\t\t\t.
\n\t\t\t
\n\t\t\t
\n\t\t\t\t
3.3. Supersonic nozzle conception
\n\t\t\t\t
For supersonic nozzle application, it is necessary to determine the thrust coefficient. For nozzles giving a uniform and parallel flow at the exit section, the thrust coefficient is (Peterson & Hill, 1965& Zebbiche, Youbi, 2005b)
The design of the nozzle is made on the basis of its application. For rockets and missiles applications, the design is made to obtain nozzles having largest possible exit Mach number, which gives largest thrust coefficient, and smallest possible length, which give smallest possible mass of structure.
\n\t\t\t\t
For the application of blowers, we make the design on the basis to obtain the smallest possible temperature at the exit section, to not to destroy the measuring instruments, and to save the ambient conditions. Another condition requested is to have possible largest ray of the exit section for the site of instruments. Between the two possibilities of construction, we prefer the first one.
\n\t\t\t
\n\t\t\t
\n\t\t\t\t
3.4. Error of perfect gas model
\n\t\t\t\t
The mathematical perfect gas model is developed on the basis to regarding the specific heat C\n\t\t\t\t\t\n\t\t\t\t\t\tP\n\t\t\t\t\t and ratio γ as constants, which gives acceptable results for low temperature. According to this study, we can notice a difference on the given results between the perfect gas model and developed here model.The error given by the PG model compared to our HT model can be calculated for each parameter. Then, for each value (T\n\t\t\t\t\t\n\t\t\t\t\t\t0\n\t\t\t\t\t\n\t\t\t\t\t, M), the ε error can be evaluated by the following relationship:
The letter y in the expression (35) can represent all above-mentioned parameters. As a rule for the aerodynamic applications, the error should be lower than 5%.
\n\t\t\t
\n\t\t
\n\t\t
\n\t\t\t
4. Application
\n\t\t\t
The design of a supersonic propulsion nozzle can be considered as example. The use of the obtained dimensioned nozzle shape based on the application of the PG model given a supersonic uniform Mach number M\n\t\t\t\t\n\t\t\t\t\tS\n\t\t\t\t at the exit section of rockets, degrades the desired performances (exit Mach number, pressure force), especially if the temperature T\n\t\t\t\t\n\t\t\t\t\t0\n\t\t\t\t of the combustion chamber is higher. We recall here that the form of the nozzle structure does not change, except the thermodynamic behaviour of the air which changes with T\n\t\t\t\t\n\t\t\t\t\t0\n\t\t\t\t. Two situations can be presented.
\n\t\t\t
The first situation presented is that, if we wants to preserve the same variation of the Mach number throughout the nozzle, and consequently, the same exit Mach number M\n\t\t\t\t\n\t\t\t\t\tE\n\t\t\t\t, is necessary to determine by the application of our model, the ray of each section and in particular the ray of the exit section, which will give the same variation of the Mach number, and consequently another shape of the nozzle will be obtained.
The relation (36) indicates that the Mach number of the PG model is preserved for each section in our calculation. Initially, we determine the temperature at each section; witch presents the solution of equation (37). To determine the ratio of the sections, we use the relation (38). The ratio of the section obtained by our model will be superior that that determined by the PG model as present equation (38). Then the shape of the nozzle obtained by PG model is included in the nozzle obtained by our model. The temperature T\n\t\t\t\t\n\t\t\t\t\t0\n\t\t\t\t presented in equation (38) is that correspond to the temperature T\n\t\t\t\t\n\t\t\t\t\t0\n\t\t\t\t for our model.
\n\t\t\t
The second situation consists to preserving the shape of the nozzle dimensioned on the basis of PG model for the aeronautical applications considered the HT model.
The relation (39) presents this situation. In this case, the nozzle will deliver a Mach number lower than desired, as shows the relation (40). The correction of the Mach number for HT model is initially made by the determination of the temperature T\n\t\t\t\t\n\t\t\t\t\tS\n\t\t\t\t as solution of equation (38), then determine the exit Mach number as solution of relation (37). The resolution of equation (38) is done by combining the dichotomy method with Simpson’s algorithm.
\n\t\t
\n\t\t
\n\t\t\t
5. Results and comments
\n\t\t\t
\n\t\t\t\tFigures 4 and 5 respectively represent the variation of specific heat C\n\t\t\t\t\n\t\t\t\t\tP\n\t\t\t\t\n\t\t\t\t(T) and the ratio γ(T) of the air versus the temperature up to 3550 K for HT and PG models. The graphs at high temperature are presented by using the polynomial interpolation (23). We can say that at low temperature until approximately 240 K, the gas can be regarded as calorically perfect, because of the invariance of specific heat C\n\t\t\t\t\n\t\t\t\t\tP\n\t\t\t\t\n\t\t\t\t(T) and the ratio γ(T). But if T\n\t\t\t\t\n\t\t\t\t\t0\n\t\t\t\t increases, we can see the difference between these values and it influences on the thermodynamic parameters of the flow.
\n\t\t\t
Figure 4.
Variation of the specific heat for constant pressure versus stagnation temperature T\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t0\n\t\t\t\t\t\t.
\n\t\t\t
Figure 5.
Variation of the specific heats ratio versus T\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t0\n\t\t\t\t\t\t.
\n\t\t\t
\n\t\t\t\t
5.1. Results for the critical parameters
\n\t\t\t\t
\n\t\t\t\t\tFigures 6, 7 and 8 represent the variation of the critical thermodynamic ratios versus T\n\t\t\t\t\t\n\t\t\t\t\t\t0\n\t\t\t\t\t. It can be seen that with enhancement T\n\t\t\t\t\t\n\t\t\t\t\t\t0\n\t\t\t\t\t\n\t\t\t\t\t, the critical parameters vary, and this variation becomes considerable for high values of T\n\t\t\t\t\t\n\t\t\t\t\t\t0\n\t\t\t\t\t unlike to the PG model, where they do not depend on T\n\t\t\t\t\t\n\t\t\t\t\t\t0.. For example, the value of the temperature ratio given by the HT model is always higher than the value given by the PG model. The ratios are determined by the choice of N=300000, b\n\t\t\t\t\t\n\t\t\t\t\t\t1\n\t\t\t\t\t=0.1 and b\n\t\t\t\t\t\n\t\t\t\t\t\t2\n\t\t\t\t\t=2.0 to have a precision better than ε=10 -5. The obtained numerical values of the critical parameters are presented in the table 3.
\n\t\t\t\t
Figure 6.
Variation of T\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t*\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t/T\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t0\n\t\t\t\t\t\t\t versus T\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t0\n\t\t\t\t\t\t\t.
\n\t\t\t\t
Figure 7.
Variation of ρ\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t*\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t/ρ\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t0\n\t\t\t\t\t\t\t versus T\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t0\n\t\t\t\t\t\t\t.
\n\t\t\t\t
Figure 8.
Variation of P\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t*\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t/P\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t0\n\t\t\t\t\t\t\t versus T\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t0\n\t\t\t\t\t\t\t.
\n\t\t\t\t
\n\t\t\t\t\tFigure 9 shows that mass flow rate through the critical cross section given by the perfect gas theory is lower than it is at the HT model, especially for values of T\n\t\t\t\t\t\n\t\t\t\t\t\t0\n\t\t\t\t\t.
\n\t\t\t\t
Figure 9.
Variation of the non-dimensional critical mass flow rate with T\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t0\n\t\t\t\t\t\t\t.
\n\t\t\t\t
\n\t\t\t\t\tFigure 10 presents the variation of the critical sound velocity ratio versus T\n\t\t\t\t\t\n\t\t\t\t\t\t0\n\t\t\t\t\t. The influence of the T\n\t\t\t\t\t\n\t\t\t\t\t\t0\n\t\t\t\t\t on this parameter can be found.
\n\t\t\t\t
Figure 10.
Effect of T\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t0\n\t\t\t\t\t\t\t on the velocity sound ratio.
\n\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
T*/T0
\n\t\t\t\t\t\t\t
P*/P0
\n\t\t\t\t\t\t\t
ρ*/ρ 0
\n\t\t\t\t\t\t\t
a*/a 0
\n\t\t\t\t\t\t\t
m/A* ρ 0 a 0
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
PG (γ=1.402)
\n\t\t\t\t\t\t\t
0.8326
\n\t\t\t\t\t\t\t
0.5279
\n\t\t\t\t\t\t\t
0.6340
\n\t\t\t\t\t\t\t
0.9124
\n\t\t\t\t\t\t\t
0.5785
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
T0=298.15 K
\n\t\t\t\t\t\t\t
0.8328
\n\t\t\t\t\t\t\t
0.5279
\n\t\t\t\t\t\t\t
0.6339
\n\t\t\t\t\t\t\t
0.9131
\n\t\t\t\t\t\t\t
0.5788
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
T0=500 K
\n\t\t\t\t\t\t\t
0.8366
\n\t\t\t\t\t\t\t
0.5293
\n\t\t\t\t\t\t\t
0.6326
\n\t\t\t\t\t\t\t
0.9171
\n\t\t\t\t\t\t\t
0.5802
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
T0=1000 K
\n\t\t\t\t\t\t\t
0.8535
\n\t\t\t\t\t\t\t
0.5369
\n\t\t\t\t\t\t\t
0.6291
\n\t\t\t\t\t\t\t
0.9280
\n\t\t\t\t\t\t\t
0.5838
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
T0=2000 K
\n\t\t\t\t\t\t\t
0.8689
\n\t\t\t\t\t\t\t
0.5448
\n\t\t\t\t\t\t\t
0.6270
\n\t\t\t\t\t\t\t
0.9343
\n\t\t\t\t\t\t\t
0.5858
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
T0=2500 K
\n\t\t\t\t\t\t\t
0.8722
\n\t\t\t\t\t\t\t
0.5466
\n\t\t\t\t\t\t\t
0.6266
\n\t\t\t\t\t\t\t
0.9355
\n\t\t\t\t\t\t\t
0.5862
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
T0=3000 K
\n\t\t\t\t\t\t\t
0.8743
\n\t\t\t\t\t\t\t
0.5475
\n\t\t\t\t\t\t\t
0.6263
\n\t\t\t\t\t\t\t
0.9365
\n\t\t\t\t\t\t\t
0.5865
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
T0=3500 K
\n\t\t\t\t\t\t\t
0.8758
\n\t\t\t\t\t\t\t
0.5484
\n\t\t\t\t\t\t\t
0.6262
\n\t\t\t\t\t\t\t
0.9366
\n\t\t\t\t\t\t\t
0.5865
\n\t\t\t\t\t\t
\n\t\t\t\t\t
Table 3.
Numerical values of the critical parameters at high temperature.
\n\t\t\t
\n\t\t\t
\n\t\t\t\t
5.2. Results for the supersonic parameters
\n\t\t\t\t
\n\t\t\t\t\tFigures 11, 12 and 13 presents the variation of the supersonic flow parameters in a cross-section versus Mach number for T\n\t\t\t\t\t\n\t\t\t\t\t\t0\n\t\t\t\t\t =1000 K, 2000 K and 3000 K, including the case of perfect gas for γ=1.402. When M=1, we can obtain the values of the critical ratios. If we take into account the variation of C\n\t\t\t\t\t\n\t\t\t\t\t\tP\n\t\t\t\t\t\n\t\t\t\t\t(T), the temperature T\n\t\t\t\t\t\n\t\t\t\t\t\t0\n\t\t\t\t\t influences on the value of the thermodynamic and geometrical parameters of flow unlike the PG model.
\n\t\t\t\t
The curve 4 of figure 11 is under the curves of the HT model, which indicates that the perfect gas model cool the flow compared to the real thermodynamic behaviour of the gas, and consequently, it influences on the dimensionless parameters of a nozzle. At low temperature and Mach number, the theory of perfect gas gives acceptable results. The obtained numerical values of the supersonic flow parameters, the cross section area ratio and sound velocity ratio are presented respectively if the tables 4, 5, 6, 7 and 8.
\n\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
T/T0
\n\t\t\t\t\t\t\t
M=2.00
\n\t\t\t\t\t\t\t
M=3.00
\n\t\t\t\t\t\t\t
M=4.00
\n\t\t\t\t\t\t\t
M=5.00
\n\t\t\t\t\t\t\t
M=6.00
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
PG (γ=1.402)
\n\t\t\t\t\t\t\t
0.5543
\n\t\t\t\t\t\t\t
0.3560
\n\t\t\t\t\t\t\t
0.2371
\n\t\t\t\t\t\t\t
0.1659
\n\t\t\t\t\t\t\t
0.1214
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
T0=298.15 K
\n\t\t\t\t\t\t\t
0.5544
\n\t\t\t\t\t\t\t
0.3560
\n\t\t\t\t\t\t\t
0.2372
\n\t\t\t\t\t\t\t
0.1659
\n\t\t\t\t\t\t\t
0.1214
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
T0=500 K
\n\t\t\t\t\t\t\t
0.5577
\n\t\t\t\t\t\t\t
0.3581
\n\t\t\t\t\t\t\t
0.2386
\n\t\t\t\t\t\t\t
0.1669
\n\t\t\t\t\t\t\t
0.1221
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
T0=1000 K
\n\t\t\t\t\t\t\t
0.5810
\n\t\t\t\t\t\t\t
0.3731
\n\t\t\t\t\t\t\t
0.2481
\n\t\t\t\t\t\t\t
0.1736
\n\t\t\t\t\t\t\t
0.1269
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
T0=1500 K
\n\t\t\t\t\t\t\t
0.6031
\n\t\t\t\t\t\t\t
0.3911
\n\t\t\t\t\t\t\t
0.2594
\n\t\t\t\t\t\t\t
0.1810
\n\t\t\t\t\t\t\t
0.1323
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
T0=2000 K
\n\t\t\t\t\t\t\t
0.6163
\n\t\t\t\t\t\t\t
0.4058
\n\t\t\t\t\t\t\t
0.2694
\n\t\t\t\t\t\t\t
0.1873
\n\t\t\t\t\t\t\t
0.1366
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
T0=2500 K
\n\t\t\t\t\t\t\t
0.6245
\n\t\t\t\t\t\t\t
0.4162
\n\t\t\t\t\t\t\t
0.2778
\n\t\t\t\t\t\t\t
0.1928
\n\t\t\t\t\t\t\t
0.1403
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
T0=3000 K
\n\t\t\t\t\t\t\t
0.6301
\n\t\t\t\t\t\t\t
0.4233
\n\t\t\t\t\t\t\t
0.2848
\n\t\t\t\t\t\t\t
0.1977
\n\t\t\t\t\t\t\t
0.1473
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
T0=3500 K
\n\t\t\t\t\t\t\t
0.6340
\n\t\t\t\t\t\t\t
0.4285
\n\t\t\t\t\t\t\t
0.2901
\n\t\t\t\t\t\t\t
0.2018
\n\t\t\t\t\t\t\t
0.1462
\n\t\t\t\t\t\t
\n\t\t\t\t\t
Table 4.
Numerical values of the temperature ratio at high temperature
\n\t\t\t\t
Figure 11.
Variation of T/T\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t0\n\t\t\t\t\t\t\t versus Mach number.
\n\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
ρ/ρ0
\n\t\t\t\t\t\t\t
M=2.00
\n\t\t\t\t\t\t\t
M=3.00
\n\t\t\t\t\t\t\t
M=4.00
\n\t\t\t\t\t\t\t
M=5.00
\n\t\t\t\t\t\t\t
M=6.00
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
PG (γ=1.402)
\n\t\t\t\t\t\t\t
0.2304
\n\t\t\t\t\t\t\t
0.0765
\n\t\t\t\t\t\t\t
0.0278
\n\t\t\t\t\t\t\t
0.0114
\n\t\t\t\t\t\t\t
0.0052
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
T0=298.15 K
\n\t\t\t\t\t\t\t
0.2304
\n\t\t\t\t\t\t\t
0.0765
\n\t\t\t\t\t\t\t
0.0278
\n\t\t\t\t\t\t\t
0.0114
\n\t\t\t\t\t\t\t
0.0052
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
T0=500 K
\n\t\t\t\t\t\t\t
0.2283
\n\t\t\t\t\t\t\t
0.0758
\n\t\t\t\t\t\t\t
0.0276
\n\t\t\t\t\t\t\t
0.0113
\n\t\t\t\t\t\t\t
0.0052
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
T0=1000 K
\n\t\t\t\t\t\t\t
0.2181
\n\t\t\t\t\t\t\t
0.0696
\n\t\t\t\t\t\t\t
0.0250
\n\t\t\t\t\t\t\t
0.0103
\n\t\t\t\t\t\t\t
0.0047
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
T0=1500 K
\n\t\t\t\t\t\t\t
0.2116
\n\t\t\t\t\t\t\t
0.0636
\n\t\t\t\t\t\t\t
0.0220
\n\t\t\t\t\t\t\t
0.0089
\n\t\t\t\t\t\t\t
0.0041
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
T0=2000 K
\n\t\t\t\t\t\t\t
0.2087
\n\t\t\t\t\t\t\t
0.0601
\n\t\t\t\t\t\t\t
0.0197
\n\t\t\t\t\t\t\t
0.0077
\n\t\t\t\t\t\t\t
0.0035
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
T0=2500 K
\n\t\t\t\t\t\t\t
0.2069
\n\t\t\t\t\t\t\t
0.0581
\n\t\t\t\t\t\t\t
0.0182
\n\t\t\t\t\t\t\t
0.0069
\n\t\t\t\t\t\t\t
0.0030
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
T0=3000 K
\n\t\t\t\t\t\t\t
0.2057
\n\t\t\t\t\t\t\t
0.0569
\n\t\t\t\t\t\t\t
0.0173
\n\t\t\t\t\t\t\t
0.0063
\n\t\t\t\t\t\t\t
0.0027
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
T0=3500 K
\n\t\t\t\t\t\t\t
0.2049
\n\t\t\t\t\t\t\t
0.0560
\n\t\t\t\t\t\t\t
0.0166
\n\t\t\t\t\t\t\t
0.0058
\n\t\t\t\t\t\t\t
0.0024
\n\t\t\t\t\t\t
\n\t\t\t\t\t
Table 5.
Numerical values of the density ratio at high temperature
\n\t\t\t\t
Figure 12.
Variation of ρ/ρ\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t0\n\t\t\t\t\t\t\t versus Mach number.
\n\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
P/P0
\n\t\t\t\t\t\t\t
M=2.00
\n\t\t\t\t\t\t\t
M=3.00
\n\t\t\t\t\t\t\t
M=4.00
\n\t\t\t\t\t\t\t
M=5.00
\n\t\t\t\t\t\t\t
M=6.00
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
PG (γ=1.402)
\n\t\t\t\t\t\t\t
0.1277
\n\t\t\t\t\t\t\t
0.0272
\n\t\t\t\t\t\t\t
0.0066
\n\t\t\t\t\t\t\t
0.0019
\n\t\t\t\t\t\t\t
0.0006
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
T0=298.15 K
\n\t\t\t\t\t\t\t
0.1277
\n\t\t\t\t\t\t\t
0.0272
\n\t\t\t\t\t\t\t
0.0066
\n\t\t\t\t\t\t\t
0.0019
\n\t\t\t\t\t\t\t
0.0006
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
T0=500 K
\n\t\t\t\t\t\t\t
0.1273
\n\t\t\t\t\t\t\t
0.0271
\n\t\t\t\t\t\t\t
0.0065
\n\t\t\t\t\t\t\t
0.0018
\n\t\t\t\t\t\t\t
0.0006
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
T0=1000 K
\n\t\t\t\t\t\t\t
0.1267
\n\t\t\t\t\t\t\t
0.0259
\n\t\t\t\t\t\t\t
0.0062
\n\t\t\t\t\t\t\t
0.0017
\n\t\t\t\t\t\t\t
0.0006
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
T0=1500 K
\n\t\t\t\t\t\t\t
0.1276
\n\t\t\t\t\t\t\t
0.0248
\n\t\t\t\t\t\t\t
0.0057
\n\t\t\t\t\t\t\t
0.0016
\n\t\t\t\t\t\t\t
0.0005
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
T0=2000 K
\n\t\t\t\t\t\t\t
0.1286
\n\t\t\t\t\t\t\t
0.0244
\n\t\t\t\t\t\t\t
0.0053
\n\t\t\t\t\t\t\t
0.0014
\n\t\t\t\t\t\t\t
0.0004
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
T0=2500 K
\n\t\t\t\t\t\t\t
0.1292
\n\t\t\t\t\t\t\t
0.0242
\n\t\t\t\t\t\t\t
0.0050
\n\t\t\t\t\t\t\t
0.0013
\n\t\t\t\t\t\t\t
0.0004
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
T0=3000 K
\n\t\t\t\t\t\t\t
0.1296
\n\t\t\t\t\t\t\t
0.0240
\n\t\t\t\t\t\t\t
0.0049
\n\t\t\t\t\t\t\t
0.0004
\n\t\t\t\t\t\t\t
0.0003
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
T0=3500 K
\n\t\t\t\t\t\t\t
0.1299
\n\t\t\t\t\t\t\t
0.0240
\n\t\t\t\t\t\t\t
0.0048
\n\t\t\t\t\t\t\t
0.0011
\n\t\t\t\t\t\t\t
0.0003
\n\t\t\t\t\t\t
\n\t\t\t\t\t
Table 6.
Numerical values of the Pressure ratio at high temperature.
\n\t\t\t\t
Figure 13.
Variation of P/P\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t0\n\t\t\t\t\t\t\t versus Mach number.
\n\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
A/A*
\n\t\t\t\t\t\t\t
M=2.00
\n\t\t\t\t\t\t\t
M=3.00
\n\t\t\t\t\t\t\t
M=4.00
\n\t\t\t\t\t\t\t
M=5.00
\n\t\t\t\t\t\t\t
M=6.00
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
PG (γ=1.402)
\n\t\t\t\t\t\t\t
1.6859
\n\t\t\t\t\t\t\t
4.2200
\n\t\t\t\t\t\t\t
10.6470
\n\t\t\t\t\t\t\t
24.7491
\n\t\t\t\t\t\t\t
52.4769
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
T0=298.15 K
\n\t\t\t\t\t\t\t
1.6859
\n\t\t\t\t\t\t\t
4.2195
\n\t\t\t\t\t\t\t
10.6444
\n\t\t\t\t\t\t\t
24.7401
\n\t\t\t\t\t\t\t
52.4516
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
T0=500 K
\n\t\t\t\t\t\t\t
1.6916
\n\t\t\t\t\t\t\t
4.2373
\n\t\t\t\t\t\t\t
10.6895
\n\t\t\t\t\t\t\t
24.8447
\n\t\t\t\t\t\t\t
52.6735
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
T0=1000 K
\n\t\t\t\t\t\t\t
1.7295
\n\t\t\t\t\t\t\t
4.4739
\n\t\t\t\t\t\t\t
11.3996
\n\t\t\t\t\t\t\t
26.5019
\n\t\t\t\t\t\t\t
56.1887
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
T0=1500 K
\n\t\t\t\t\t\t\t
1.7582
\n\t\t\t\t\t\t\t
4.7822
\n\t\t\t\t\t\t\t
12.6397
\n\t\t\t\t\t\t\t
29.7769
\n\t\t\t\t\t\t\t
63.2133
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
T0=2000 K
\n\t\t\t\t\t\t\t
1.7711
\n\t\t\t\t\t\t\t
4.9930
\n\t\t\t\t\t\t\t
13.8617
\n\t\t\t\t\t\t\t
33.5860
\n\t\t\t\t\t\t\t
72.0795
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
T0=2500 K
\n\t\t\t\t\t\t\t
1.7795
\n\t\t\t\t\t\t\t
5.1217
\n\t\t\t\t\t\t\t
14.8227
\n\t\t\t\t\t\t\t
37.2104
\n\t\t\t\t\t\t\t
81.2941
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
T0=3000 K
\n\t\t\t\t\t\t\t
1.7851
\n\t\t\t\t\t\t\t
5.2091
\n\t\t\t\t\t\t\t
15.5040
\n\t\t\t\t\t\t\t
40.3844
\n\t\t\t\t\t\t\t
90.4168
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
T0=3500 K
\n\t\t\t\t\t\t\t
1.7889
\n\t\t\t\t\t\t\t
5.2727
\n\t\t\t\t\t\t\t
16.0098
\n\t\t\t\t\t\t\t
43.0001
\n\t\t\t\t\t\t\t
98.7953
\n\t\t\t\t\t\t
\n\t\t\t\t\t
Table 7.
Numerical Values of the cross section area ratio at high temperature.
\n\t\t\t\t
\n\t\t\t\t\tFigure 14 represent the variation of the critical cross-section area section ratio versus Mach number at high temperature. For low values of Mach number and T\n\t\t\t\t\t\n\t\t\t\t\t\t0\n\t\t\t\t\t, the four curves fuses and start to be differs when M>2.00. We can see that the curves 3 and 4 are almost superposed for any value of T\n\t\t\t\t\t\n\t\t\t\t\t\t0\n\t\t\t\t\t. This result shows that the PG model can be used for T\n\t\t\t\t\t\n\t\t\t\t\t\t0\n\t\t\t\t\t<1000 K.
\n\t\t\t\t
\n\t\t\t\t\tFigure 15 presents the variation of the sound velocity ratio versus Mach number at high temperature. T\n\t\t\t\t\t\n\t\t\t\t\t\t0\n\t\t\t\t\t value influences on this parameter.
\n\t\t\t\t
\n\t\t\t\t\tFigure 16 shows the variation of the thrust coefficient versus exit Mach number for various values of T\n\t\t\t\t\t\n\t\t\t\t\t\t0\n\t\t\t\t\t. It can be seen the effect of T\n\t\t\t\t\t\n\t\t\t\t\t\t0\n\t\t\t\t\t on this parameter. We can found that all the four curves are almost confounded when M\n\t\t\t\t\t\n\t\t\t\t\t\tE\n\t\t\t\t\t\n\t\t\t\t\t<2.00 approximately. After this value, the curves begin to separates progressively. The numerical values of the thrust coefficient are presented in the table 9.
\n\t\t\t\t
Figure 14.
Variation of the critical cross-section area ratio versus Mach number.
\n\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
a/a0
\n\t\t\t\t\t\t\t
M=2.00
\n\t\t\t\t\t\t\t
M=3.00
\n\t\t\t\t\t\t\t
M=4.00
\n\t\t\t\t\t\t\t
M=5.00
\n\t\t\t\t\t\t\t
M=6.00
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
PG (γ=1.402)
\n\t\t\t\t\t\t\t
0.7445
\n\t\t\t\t\t\t\t
0.5966
\n\t\t\t\t\t\t\t
0.4870
\n\t\t\t\t\t\t\t
0.4074
\n\t\t\t\t\t\t\t
0.3484
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
T0=298.15 K
\n\t\t\t\t\t\t\t
0.7450
\n\t\t\t\t\t\t\t
0.5970
\n\t\t\t\t\t\t\t
0.4873
\n\t\t\t\t\t\t\t
0.4076
\n\t\t\t\t\t\t\t
0.3486
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
T0=500 K
\n\t\t\t\t\t\t\t
0.7510
\n\t\t\t\t\t\t\t
0.6019
\n\t\t\t\t\t\t\t
0.4913
\n\t\t\t\t\t\t\t
0.4110
\n\t\t\t\t\t\t\t
0.3515
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
T0=1000 K
\n\t\t\t\t\t\t\t
0.7739
\n\t\t\t\t\t\t\t
0.6245
\n\t\t\t\t\t\t\t
0.5103
\n\t\t\t\t\t\t\t
0.4268
\n\t\t\t\t\t\t\t
0.3651
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
T0=1500 K
\n\t\t\t\t\t\t\t
0.7862
\n\t\t\t\t\t\t\t
0.6408
\n\t\t\t\t\t\t\t
0.5254
\n\t\t\t\t\t\t\t
0.4398
\n\t\t\t\t\t\t\t
0.3762
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
T0=2000 K
\n\t\t\t\t\t\t\t
0.7923
\n\t\t\t\t\t\t\t
0.6501
\n\t\t\t\t\t\t\t
0.5354
\n\t\t\t\t\t\t\t
0.4489
\n\t\t\t\t\t\t\t
0.3841
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
T0=2500 K
\n\t\t\t\t\t\t\t
0.7959
\n\t\t\t\t\t\t\t
0.6556
\n\t\t\t\t\t\t\t
0.5420
\n\t\t\t\t\t\t\t
0.4553
\n\t\t\t\t\t\t\t
0.3898
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
T0=3000 K
\n\t\t\t\t\t\t\t
0.7985
\n\t\t\t\t\t\t\t
0.6595
\n\t\t\t\t\t\t\t
0.5465
\n\t\t\t\t\t\t\t
0.4600
\n\t\t\t\t\t\t\t
0.3942
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
T0=3500 K
\n\t\t\t\t\t\t\t
0.7998
\n\t\t\t\t\t\t\t
0.6618
\n\t\t\t\t\t\t\t
0.5495
\n\t\t\t\t\t\t\t
0.4632
\n\t\t\t\t\t\t\t
0.3973
\n\t\t\t\t\t\t
\n\t\t\t\t\t
Table 8.
Numerical values of the sound velocity ratio at high temperature.
\n\t\t\t\t
Figure 15.
Variation of the ratio of the velocity sound versus Mach number.
\n\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
CF
\n\t\t\t\t\t\t\t
M=2.00
\n\t\t\t\t\t\t\t
M=3.00
\n\t\t\t\t\t\t\t
M=4.00
\n\t\t\t\t\t\t\t
M=5.00
\n\t\t\t\t\t\t\t
M=6.00
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
PG (γ=1.402)
\n\t\t\t\t\t\t\t
1.2078
\n\t\t\t\t\t\t\t
1.4519
\n\t\t\t\t\t\t\t
1.5802
\n\t\t\t\t\t\t\t
1.6523
\n\t\t\t\t\t\t\t
1.6959
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
T0=298.15 K
\n\t\t\t\t\t\t\t
1.2078
\n\t\t\t\t\t\t\t
1.4518
\n\t\t\t\t\t\t\t
1.5800
\n\t\t\t\t\t\t\t
1.6521
\n\t\t\t\t\t\t\t
1.6957
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
T0=500 K
\n\t\t\t\t\t\t\t
1.2076
\n\t\t\t\t\t\t\t
1.4519
\n\t\t\t\t\t\t\t
1.5802
\n\t\t\t\t\t\t\t
1.6523
\n\t\t\t\t\t\t\t
1.6958
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
T0=1000 K
\n\t\t\t\t\t\t\t
1.2072
\n\t\t\t\t\t\t\t
1.4613
\n\t\t\t\t\t\t\t
1.5919
\n\t\t\t\t\t\t\t
1.6646
\n\t\t\t\t\t\t\t
1.7085
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
T0=1500 K
\n\t\t\t\t\t\t\t
1.2062
\n\t\t\t\t\t\t\t
1.4748
\n\t\t\t\t\t\t\t
1.6123
\n\t\t\t\t\t\t\t
1.6871
\n\t\t\t\t\t\t\t
1.7317
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
T0=2000 K
\n\t\t\t\t\t\t\t
1.2048
\n\t\t\t\t\t\t\t
1.4832
\n\t\t\t\t\t\t\t
1.6288
\n\t\t\t\t\t\t\t
1.7069
\n\t\t\t\t\t\t\t
1.7527
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
T0=2500 K
\n\t\t\t\t\t\t\t
1.2042
\n\t\t\t\t\t\t\t
1.4879
\n\t\t\t\t\t\t\t
1.6401
\n\t\t\t\t\t\t\t
1.7221
\n\t\t\t\t\t\t\t
1.7694
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
T0=3000 K
\n\t\t\t\t\t\t\t
1.2038
\n\t\t\t\t\t\t\t
1.4912
\n\t\t\t\t\t\t\t
1.6479
\n\t\t\t\t\t\t\t
1.7337
\n\t\t\t\t\t\t\t
1.7828
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
T0=3500 K
\n\t\t\t\t\t\t\t
1.2033
\n\t\t\t\t\t\t\t
1.4936
\n\t\t\t\t\t\t\t
1.6533
\n\t\t\t\t\t\t\t
1.7422
\n\t\t\t\t\t\t\t
1.7932
\n\t\t\t\t\t\t
\n\t\t\t\t\t
Table 9.
Numerical values of the thrust coefficient at high temperature
\n\t\t\t
\n\t\t\t
Figure 16.
Variation of C\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tF\n\t\t\t\t\t\t versus exit Mach number.
\n\t\t\t
\n\t\t\t\t
5.3. Results for the error given by the perfect gas model
\n\t\t\t\t
\n\t\t\t\t\tFigure 17 presents the relative error of the thermodynamic and geometrical parameters between the PG and the HT models for several T\n\t\t\t\t\t\n\t\t\t\t\t\t0\n\t\t\t\t\t values.
\n\t\t\t\t
It can be seen that the error depends on the values of T\n\t\t\t\t\t\n\t\t\t\t\t\t0\n\t\t\t\t\t and M. For example, if T\n\t\t\t\t\t\n\t\t\t\t\t\t0\n\t\t\t\t\t=2000 K and M=3.00, the use of the PG model will give a relative error equal to ε=14.27 % for the temperatures ratio, ε=27.30 % for the density ratio, error ε=15.48 % for the critical sections ratio and ε=2.11 % for the thrust coefficient. For lower values of M and T\n\t\t\t\t\t\n\t\t\t\t\t\t0\n\t\t\t\t\t, the error ε is weak. The curve 3 in the figure 17 is under the error 5% independently of the Mach number, which is interpreted by the use potential of the PG model when T\n\t\t\t\t\t\n\t\t\t\t\t\t0\n\t\t\t\t\t\n\t\t\t\t\t<1000 K.\n\t\t\t\t
\n\t\t\t\t
We can deduce for the error given by the thrust coefficient that it is equal to ε=0.0 %, if M\n\t\t\t\t\t\n\t\t\t\t\t\tE\n\t\t\t\t\t=2.00 approximately independently of T\n\t\t\t\t\t\n\t\t\t\t\t\t0\n\t\t\t\t\t\n\t\t\t\t\t. There is no intersection of the three curves in the same time. When M\n\t\t\t\t\t\n\t\t\t\t\t\tE\n\t\t\t\t\t=2.00.\n\t\t\t\t
\n\t\t\t
\n\t\t\t
Figure 17.
Variation of the relative error given by supersonic parameters of PG versus Mach number.
\n\t\t\t
\n\t\t\t\t
5.4. Results for the supersonic nozzle application
\n\t\t\t\t
\n\t\t\t\t\tFigure 18 presents the variation of the Mach number through the nozzle for T\n\t\t\t\t\t\n\t\t\t\t\t\t0\n\t\t\t\t\t=1000 K, 2000 K and 3000 K, including the case of perfect gas presented by curve 4. The example is selected for M\n\t\t\t\t\t\n\t\t\t\t\t\tS\n\t\t\t\t\t=3.00 for the PG model. If T\n\t\t\t\t\t\n\t\t\t\t\t\t0\n\t\t\t\t\t is taken into account, we will see a fall in Mach number of the dimensioned nozzle in comparison with the PG model. The more is the temperature T\n\t\t\t\t\t\n\t\t\t\t\t\t0\n\t\t\t\t\t, the more it is this fall. Consequently, the thermodynamics parameters force to design the nozzle with different dimensions than it is predicted by use the PG model. It should be noticed that the difference becomes considerable if the value T\n\t\t\t\t\t\n\t\t\t\t\t\t0\n\t\t\t\t\t exceeds 1000 K.
\n\t\t\t\t
\n\t\t\t\t\tFigure 19 present the correction of the Mach number of nozzle giving exit Mach number M\n\t\t\t\t\t\n\t\t\t\t\t\tS\n\t\t\t\t\t, dimensioned on the basis of the PG model for various values of T\n\t\t\t\t\t\n\t\t\t\t\t\t0\n\t\t\t\t\t.
\n\t\t\t\t
One can see that the curves confound until Mach number M\n\t\t\t\t\t\n\t\t\t\t\t\tS\n\t\t\t\t\t\n\t\t\t\t\t=2.0 for the whole range of T\n\t\t\t\t\t\n\t\t\t\t\t\t0\n\t\t\t\t\t. From this value, the difference between the three curves 1, 2 and 3, start to increase. The curves 3 and 4 are almost confounded whatever the Mach number if the value of T\n\t\t\t\t\t\n\t\t\t\t\t\t0\n\t\t\t\t\t is lower than 1000 K. For example, if the nozzle delivers a Mach number M\n\t\t\t\t\t\n\t\t\t\t\t\tS\n\t\t\t\t\t\n\t\t\t\t\t=3.00 at the exit section, on the assumption of the PG model, the HT model gives Mach number equal to M\n\t\t\t\t\t\n\t\t\t\t\t\tS\n\t\t\t\t\t=2.93, 2.84 and 2.81 for T\n\t\t\t\t\t\n\t\t\t\t\t\t0\n\t\t\t\t\t=1000 K, 2000 K and 3000 K respectively. The numerical values of the correction of the exit Mach number of the nozzle are presented in the table 10.
\n\t\t\t\t
Figure 18.
Effect of stagnation temperature on the variation of the Mach number through the nozzle.
\n\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
MS (PG γ=1.402)
\n\t\t\t\t\t\t\t
1.5000
\n\t\t\t\t\t\t\t
2.0000
\n\t\t\t\t\t\t\t
3.0000
\n\t\t\t\t\t\t\t
4.0000
\n\t\t\t\t\t\t\t
5.0000
\n\t\t\t\t\t\t\t
6.0000
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
MS (T0=298.15 K)
\n\t\t\t\t\t\t\t
1.4995
\n\t\t\t\t\t\t\t
1.9995
\n\t\t\t\t\t\t\t
2.9995
\n\t\t\t\t\t\t\t
3.9993
\n\t\t\t\t\t\t\t
4.9989
\n\t\t\t\t\t\t\t
5.9985
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
MS (T0=500 K)
\n\t\t\t\t\t\t\t
1.4977
\n\t\t\t\t\t\t\t
1.9959
\n\t\t\t\t\t\t\t
2.9956
\n\t\t\t\t\t\t\t
3.9955
\n\t\t\t\t\t\t\t
4.9951
\n\t\t\t\t\t\t\t
5.9947
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
MS (T0=1000 K)
\n\t\t\t\t\t\t\t
1.4879
\n\t\t\t\t\t\t\t
1.9705
\n\t\t\t\t\t\t\t
2.9398
\n\t\t\t\t\t\t\t
3.9237
\n\t\t\t\t\t\t\t
4.9145
\n\t\t\t\t\t\t\t
5.9040
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
MS (T0=1500 K)
\n\t\t\t\t\t\t\t
1.4830
\n\t\t\t\t\t\t\t
1.9534
\n\t\t\t\t\t\t\t
2.8777
\n\t\t\t\t\t\t\t
3.8147
\n\t\t\t\t\t\t\t
4.7727
\n\t\t\t\t\t\t\t
5.7411
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
MS (T0=2000 K)
\n\t\t\t\t\t\t\t
1.4807
\n\t\t\t\t\t\t\t
1.9463
\n\t\t\t\t\t\t\t
2.8432
\n\t\t\t\t\t\t\t
3.7293
\n\t\t\t\t\t\t\t
4.6372
\n\t\t\t\t\t\t\t
5.5675
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
MS (T0=2500 K)
\n\t\t\t\t\t\t\t
1.4792
\n\t\t\t\t\t\t\t
1.9417
\n\t\t\t\t\t\t\t
2.8245
\n\t\t\t\t\t\t\t
3.6765
\n\t\t\t\t\t\t\t
4.5360
\n\t\t\t\t\t\t\t
5.4209
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
MS (T0=3000 K)
\n\t\t\t\t\t\t\t
1.4785
\n\t\t\t\t\t\t\t
1.9388
\n\t\t\t\t\t\t\t
2.8121
\n\t\t\t\t\t\t\t
3.6454
\n\t\t\t\t\t\t\t
4.4676
\n\t\t\t\t\t\t\t
5.3066
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
MS (T0=3500 K)
\n\t\t\t\t\t\t\t
1.4778
\n\t\t\t\t\t\t\t
1.9368
\n\t\t\t\t\t\t\t
2.8035
\n\t\t\t\t\t\t\t
3.6241
\n\t\t\t\t\t\t\t
4.4216
\n\t\t\t\t\t\t\t
5.2237
\n\t\t\t\t\t\t
\n\t\t\t\t\t
Table 10.
Correction of the exit Mach number of the nozzle.
\n\t\t\t\t
\n\t\t\t\t\tFigure 20 presents the supersonic nozzles shapes delivering a same variation of the Mach number throughout the nozzle and consequently given the same exit Mach number M\n\t\t\t\t\t\n\t\t\t\t\t\tS\n\t\t\t\t\t=3.00. The variation of the Mach number through these 4 nozzles is illustrated on curve 4 of figure 18. The three other curves 1, 2, and, 3 of figure 15 are obtained with the HT model use for T\n\t\t\t\t\t\n\t\t\t\t\t\t0\n\t\t\t\t\t=3000 K, 2000 K and 1000 K respectively. The curve 4 of figure 20 is the same as it is in the figure 13a, and it is calculated with the PG model use. The nozzle that is calculated according to the PG model provides less cross-section area in comparison with the HT model.
\n\t\t\t\t
Figure 19.
Correction of the Mach number at High Temperature of a nozzle dimensioned on the perfect gas model.
\n\t\t\t
\n\t\t
\n\t\t
Figure 20.
Shapes of nozzles at high temperature corresponding to same Mach number variation througout the nozzle and given M\n\t\t\t\t\t\n\t\t\t\t\t\tS\n\t\t\t\t\t=3.00 at the exit.
\n\t\t
\n\t\t\t
6. Conclusion
\n\t\t\t
From this study, we can quote the following points:
\n\t\t\t
If we accept an error lower than 5%, we can study a supersonic flow using a perfect gas relations, if the stagnation temperature T\n\t\t\t\t\n\t\t\t\t\t0\n\t\t\t\t is lower than 1000 K for any value of Mach number, or when the Mach number is lower than 2.0 for any value of T\n\t\t\t\t\n\t\t\t\t\t0\n\t\t\t\t up to approximately 3000 K.
\n\t\t\t
The PG model is represented by an explicit and simple relations, and do not request a high time to make calculation, unlike the proposed model, which requires the resolution of a nonlinear algebraic equations, and integration of two complex analytical functions. It takes more time for calculation and for data processing.
\n\t\t\t
The basic variable for our model is the temperature and for the PG model is the Mach number because of a nonlinear implicit equation connecting the parameters T and M.
\n\t\t\t
The relations presented in this study are valid for any interpolation chosen for the function C\n\t\t\t\tP\n\t\t\t\t(T). The essential one is that the selected interpolation gives small error.
\n\t\t\t
We can choose another substance instead of the air. The relations remain valid, except that it is necessary to have the table of variation of CP and γ according to the temperature and to make a suitable interpolation.
\n\t\t\t
The cross section area ratio presented by the relation (19) can be used as a source of comparison for verification of the dimensions calculation of various supersonic nozzles. It provides a uniform and parallel flow at the exit section by the method of characteristics and the Prandtl Meyer function (Zebbiche & Youbi, 2005a, 2005b, Zebbiche, 2007, Zebbiche, 2010a& Zebbiche, 2010b). The thermodynamic ratios can be used to determine the design parameters of the various shapes of nozzles under the basis of the HT model.
\n\t\t\t
We can obtain the relations of a perfect gas starting from the relations of our model by annulling all constants of interpolation except the first. In this case, the PG model becomes a particular case of our model.
\n\t\t
\n\t
Acknowledgments
\n\t\t\t
The author acknowledges Djamel, Khaoula, Abdelghani Amine, Ritadj Zebbiche and Fettoum Mebrek for granting time to prepare this manuscript.
\n\t\t
\n',keywords:null,chapterPDFUrl:"https://cdn.intechopen.com/pdfs/21859.pdf",chapterXML:"https://mts.intechopen.com/source/xml/21859.xml",downloadPdfUrl:"/chapter/pdf-download/21859",previewPdfUrl:"/chapter/pdf-preview/21859",totalDownloads:3192,totalViews:278,totalCrossrefCites:1,totalDimensionsCites:1,totalAltmetricsMentions:0,introChapter:null,impactScore:0,impactScorePercentile:7,impactScoreQuartile:1,hasAltmetrics:0,dateSubmitted:"November 4th 2010",dateReviewed:"March 7th 2011",datePrePublished:null,datePublished:"November 2nd 2011",dateFinished:null,readingETA:"0",abstract:null,reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/21859",risUrl:"/chapter/ris/21859",book:{id:"297",slug:"thermodynamics-interaction-studies-solids-liquids-and-gases"},signatures:"Toufik Zebbiche",authors:[{id:"35644",title:"Dr.",name:"Zebbiche",middleName:null,surname:"Toufik",fullName:"Zebbiche Toufik",slug:"zebbiche-toufik",email:"z_toufik270169@yahoo.fr",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Mathematical formulation",level:"1"},{id:"sec_3",title:"3. Calculation procedure",level:"1"},{id:"sec_3_2",title:"3.2. Parameters for a supersonic Mach number",level:"2"},{id:"sec_4_2",title:"3.3. Supersonic nozzle conception",level:"2"},{id:"sec_5_2",title:"3.4. Error of perfect gas model",level:"2"},{id:"sec_7",title:"4. Application",level:"1"},{id:"sec_8",title:"5. Results and comments",level:"1"},{id:"sec_8_2",title:"5.1. Results for the critical parameters",level:"2"},{id:"sec_9_2",title:"5.2. Results for the supersonic parameters",level:"2"},{id:"sec_10_2",title:"5.3. Results for the error given by the perfect gas model",level:"2"},{id:"sec_11_2",title:"5.4. Results for the supersonic nozzle application",level:"2"},{id:"sec_13",title:"6. Conclusion",level:"1"},{id:"sec_14",title:"Acknowledgments",level:"1"}],chapterReferences:[{id:"B1",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tAnderson\n\t\t\t\t\t\t\tJ. 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J.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1988 Computational Techniques for Fluid Dynamics: Specific Techniques for Different Flow Categories, Vol. II, Springer Verlag, 0-38718-759-6 Heidelberg.\n\t\t\t'},{id:"B5",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMoran\n\t\t\t\t\t\t\tM. J.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2007\n\t\t\t\t\tFundamentals of Engineering Thermodynamics, John Wiley & Sons Inc., 6th Edition, 978-8-0471787358 USA\n\t\t\t'},{id:"B6",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tOosthuisen\n\t\t\t\t\t\t\tP. H.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCarscallen\n\t\t\t\t\t\t\tW. E.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1997 Compressible Fluid Flow. Mc Grw-Hill, 0-07-0158752-9 York, USA.\n\t\t\t'},{id:"B7",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPeterson\n\t\t\t\t\t\t\tC. R.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHill\n\t\t\t\t\t\t\tP. G.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1965\n\t\t\t\t\tMechanics and Thermodynamics of Propulsion, Addition-Wesley Publishing Company Inc., 0-20102-838-7 York, USA.\n\t\t\t'},{id:"B8",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRalston\n\t\t\t\t\t\t\tA.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRabinowitz\n\t\t\t\t\t\t\tP. A.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1985\n\t\t\t\t\tA First Course in Numerical Analysis. (2nd Edition), McGraw-Hill Book Company, 0-07051-158-6 York, USA.\n\t\t\t'},{id:"B9",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRyhming\n\t\t\t\t\t\t\tI. L.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1984\n\t\t\t\t\tDynamique des fluides, Presses Polytechniques Romandes, Lausanne, 2-88074-224-2\n\t\t\t\t\n\t\t\t'},{id:"B10",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tZebbiche\n\t\t\t\t\t\t\tT.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2007\n\t\t\t\t\tStagnation Temperature Effect on the Prandtl Meyer Function. AIAA Journal, 45 N 04, 952\n\t\t\t\t\t954 , April 2007, 0001-1452 USA\n\t\t\t'},{id:"B11",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tZebbiche\n\t\t\t\t\t\t\tT.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tYoubi\n\t\t\t\t\t\t\tZ.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2005a Supersonic Flow Parameters at High Temperature. Application for Air in nozzles. German Aerospace Congress 2005, DGLR-2005-0256, 26-29 Sep. 2005, 978-3-83227-492-4 Friendrichshafen, Germany.\n\t\t\t'},{id:"B12",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tZebbiche\n\t\t\t\t\t\t\tT.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tYoubi\n\t\t\t\t\t\t\tZ.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2005b Supersonic Two-Dimensional Minimum Length Nozzle Conception. Application for Air. German Aerospace Congress 2005, DGLR-2005-0257, 26-29 Sep. 2005, 978-3-83227-492-4 Friendrichshafen, Germany.\n\t\t\t'},{id:"B13",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tZebbiche\n\t\t\t\t\t\t\tT.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tYoubi\n\t\t\t\t\t\t\tZ.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2006 Supersonic Plug Nozzle Design at High Temperature. Application for Air, AIAA Paper 2006\n\t\t\t\t\t0592\n\t\t\t\t\tth AIAA Aerospace Sciences Meeting and Exhibit, 9-12 Jan. 2006, 978-1-56347-893-2 Reno Nevada, Hilton, USA.\n\t\t\t'},{id:"B14",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tZebbiche\n\t\t\t\t\t\t\tT.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2010a Supersonic Axisymetric Minimum Length Conception at High Temperature with Application for Air. Journal of British Interplanetary Society (JBIS), 63 N 04-05, 171\n\t\t\t\t\t192 , May-June 2010, 0007\n\t\t\t\t\n\t\t\t'},{id:"B15",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tZebbiche\n\t\t\t\t\t\t\tT.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2010b\n\t\t\t\t\tTuyères Supersoniques à Haute Température. Editions Universitaires Européennes. 978-6-13150-997-1 Dudweiler Landstrabe, Sarrebruck, Germany.\n\t\t\t'},{id:"B16",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tZuker\n\t\t\t\t\t\t\tR. D.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBilbarz\n\t\t\t\t\t\t\tO.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2002\n\t\t\t\t\tFundamentals of Gas Dynamics, John Wiley & Sons. 0-47105-967-6 York, USA\n\t\t\t'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Toufik Zebbiche",address:null,affiliation:'
University SAAD Dahleb of Blida, Algeria
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1. Introduction
Peroxisome proliferator-activated receptor gamma (PPARγ) is a transcription factor that is activated by ligand binding as well as via ligand-independent activation. PPARγ plays an active role in regulation of glucose and lipid metabolism but more recently has been examined for its role in numerous disease states including: diabetes, cardiovascular disease, cancer, inflammation, angiogenesis and metastasis [1, 2, 3, 4, 5, 6]. Some research also suggests it provides potential for anti-aging activity [7]. Prior to the discovery of the thiazolidinedione (TZD) drugs used for treatment of diabetes, the general consensus was that PPARγ was subject only to ligand-independent activation [8]. It was the discovery of these drugs that suggested that PPARγ was also sensitive to ligand-dependent activation [8, 9, 10, 11]. The goal of the first generation TZDs was to target insulin sensitivity and although the drugs were successful with this they were not without toxicity concerns. The focus more recently has looked to natural methods to accomplish therapeutic level results and PPARγ provides a viable target with multiple mechanisms available for activation and a variety of functional food sources for PPARγ ligands.
PPARγ is a member of the nuclear receptors gene subfamily and is found on chromosome 3. Other members of the gene family include PPARα and PPARβ/δ. In addition due to alternative splicing, there are multiple isoforms of PPARγ, known as PPARγ1 and PPARγ2 [12, 13]. PPARγ1 is expressed at high levels in white and brown adipose tissue, however, lower levels of expression of PPARγ1 are found in all tissues as well as the immune cells. PPARγ2 is expressed only in white and brown adipose tissue [14]. Although disease states are sometimes related to changes in expression of these isoforms and inefficient signaling associated with the pathway, some research has demonstrated that specific variants have been linked to early onset type 2 diabetes. Nearly half of these patients had a variant in PPARγ2 resulting in an amino acid substitution of tyrosine to cysteine in the activation function domain 1 (AF1). Of note is also that of these patients, 83% also had diabetic kidney disease [15]. Another study demonstrated that loss of function mutation of arginine 288 to histidine in the ligand-binding domain (LBD) resulted in significant conformational changes in the protein that lead to blunting of the activation via prostaglandins [16].
Mouse studies have shown that knockout of PPARγ2 results in insulin resistance [13]. In contrast, it was demonstrated that activation of PPARγ in mouse adipocytes improves insulin sensitivity [17]. Together these studies support the effects of PPARγ activity on insulin resistance and type 2 diabetes in addition to its known role in adipocyte differentiation [12, 18]. PPARγ also controls the expression of the skeletal muscle and adipose glucose transporter (GLUT4), and adipose tissue based hormones adiponectin, resistin and leptin [19, 20, 21]. It is clear from these studies that modulation of PPARγ activity plays a significant role in patient wellness considering the effects of activation on glucose homeostasis, lipid metabolism and adipocyte differentiation. These effects strongly suggest that activation of PPARγ in a controlled fashion provide strong potential for improvement of patient quality of life. Nutraceuticals offer this type of low level controlled activation that may benefit the patient even beyond the potential for the synthetic drugs targeting PPARγ activation.
The structure of PPARγ contains multiple protein domains of importance as shown in Figure 1. The individual domains are separated based on function and can themselves be modified in most cases. The activation function domain 1 (AF1) is on the N-terminus and is subject to phosphorylation, and small ubiquitin like modifiers (SUMOylation). In general SUMOylation leads to suppression of transcriptional activity while ubiquitination increase transcriptional activity. Phosphorylation can increase or decrease transcriptional activity depending on the site of phosphorylation and the enzyme catalyzing the phosphorylation event. In general deacetylation by Sirt-1, the histone deacetylase leads to dissociation of the nuclear receptor corepressor (NCoR) and increased transcriptional activity [22]. The next domain is the DNA binding domain (DBD) responsible for interacting with the DNA in conjunction with the retinoid c receptor (RXR). RXR houses a binding site for 9-cis-retinoic acid, which when bound allows RXR to complex with the PPARγ complex and interaction with DNA [23]. The HD domain is a regulatory domain named due to the histidine (H)-aspartate (D) amino acids conserved in the region. The HD domain interacts with either the coactivator, peroxisome proliferator-activated receptor gamma coactivator (PGC-1α) or the corepressors NCoR and silencing mediator of retinoid and thyroid hormone receptors (SMRT) [24]. On the C-terminal end is the ligand binding domain (LBD) that when ligand bound by an activator, stimulates transcription. When no ligand is bound, and the corepressor is bound, transcription is limited. The LBD is also subject to phosphorylation, ubiquitination, SUMOylation and acetylation. Each of these affect the likelihood of ligand activation. Of interest are the histone deacetylase enzyme (HDAC) which deacetylate the ligand binding domain. Inhibition of this HDAC, limits deacetylation of the LBD and leads towards PPARγ activation via the ligand independent pathway [25].
Figure 1.
The structure of PPARγ. AF-1 is the activated function 1 domain. A/B houses a SUMOylation (S) and phosphorylation (P) site. DBD is the DNA binding domain. HD is the conserved protein domain with histidine and aspartate that interacts with the coactivator PGC-1α. The ligand binding domain (LBD) is attached via a hinge region and houses a SUMOylation, phosphorylation, ubiquitination (Ub) and two acetylation (Ac) sites. AF-2 is the activated function.
The PPARγ pathway involves several overlapping cellular functions. Activation of PPARγ, either ligand-independent or ligand dependent, leads to change in the immune system, metabolic organs including skeletal muscle and adipose tissue [26, 27, 28]. For example in the immune system macrophages and regular T cells, activation of PPARγ in general will decrease inflammation. Inflammation is decreased in the heart and brain but lipid storage is increased in the heart as well as growth. In white adipose tissue lipid metabolism and glucose homeostasis is improved with activation. Of particular interest is the fact that activation of PPARγ increases remodeling and browning of white adipose tissue, a benefit that will likely lead to better ability for patients to manage weight (ref). It is clear that there are strong benefits to PPARγ activation, but potential side effects such as lipid storage in the heart, sodium and fluid retention and increased desire for food can also result in unwanted effects [22].
It is important to consider how PPARγ activation can be achieved while minimizing the potentially harmful side effects. A benefit also exists to activate PPARγ in a ligand dependent fashion versus the ligand independent activation. Endogenous ligands to PPARγ are typically fairly weak agonists while the TZDs are strong agonists [8, 29]. The first generation TZD troglitazone was pulled from the market in the US approximately 3 years after first becoming available because it resulted in severe or fatal hepatotoxicity in numerous cases [30, 31, 32, 33, 34]. Other TZDs were taken off the European market and restricted in the US markets due to potentially dangerous side effects including myocardial infarction, heart failure, hepatic failure [35, 36, 37, 38]. It is still currently believed that these side effects resulted in part to the full PPARγ activation rather than the moderate activation offered by the weaker ligand agonists [29]. Gene expression, especially expression of genes involved in metabolic process that are sensitive to endogenous ligands as well, should be tightly controlled with an effective regulatory method that allows frequent adjustment of expression levels in response to the environment. Altering expression of genes fully by fully activating PPARγ poses several concerns, especially since there is so much overlap within the PPARγ activation pathway. Thus, an increased emphasis on natural and less specific activators is warranted. Natural ligands are particularly useful in this situation because the full and permanent activation is not desired. Given the range of disease state linked to PPARγ signaling, exploring the potential natural food based ligands is an essential tool in moving patient wellness forward.
2. Food sources and therapeutic potential
Several herbs and foods have been used medicinally for centuries, although mechanism of action was not known and in some cases remains unclear. Many of the compounds found in common herbs and foods have been discovered to be ligands of the nuclear receptors such as PPARγ. A variety of studies presented summarize the compound identified to harbor therapeutic potential as a PPARγ ligand resulting in partial activation of the transcription factor and expression of a variety of metabolic and growth genes. Many of these compounds are found in overlapping herbs or spices. For example, cinnamon contains numerous compounds that are demonstrated ligands including: 2-hydroxychalcone, cinnamaldehyde, catechin, eugenol, ethylcinnamate, epicatechin, and cinnaminc acid. As expected, cinnamon has been used medicinally to treat digestive disorders and metabolic problems for decades.
Given the large number of compounds that function as PPARγ ligands, detailed discussion of each is warranted, but an overall summary is also important. Table 1 identifies several of the compounds of interest, their food sources and conveniently lists references that pertain to the studies. Apigenin acts as a partial agonist for PPARγ, inducing an effect of agonism in the absence of a full agonist, and antagonism in the presence of a full agonist. This is due to the low binding affinity that apigenin has for PPARγ itself [6, 39]. However, even with this low binding affinity, it has shown to still produce beneficial effects through this pathway. Due to its interactions with PPARγ, apigenin has anti-inflammatory effects, and has been used for treatment of colitis, or inflammation of the intestines. However, beyond its interactions with PPARγ, apigenin has also been shown to decrease food-intake, and help with weight loss [39]. Apigenin has a lot of potential clinical use and application, and can be found in marjoram, sage, thyme, holy basil, parsley, and alfalfa [6, 39].
Select compounds that function as PPARγ agonists and the food sources.
2-Hydroxychalcone is another example of a partial agonist for PPARγ. Similar to apigenin, this partial agonism of PPARγ leads to anti-inflammatory effects induced by 2-Hydroxychalcone. Although the pathways for these effects are not yet understood in the case of 2-Hydroxychalcone, it is an example of a PPARγ ligand that has shown anti-inflammatory effects [4, 6, 39]. As for food sources of 2-Hydroxychalcone, it is primarily found in cinnamon [6, 39].
Luteolin acts as a partial agonist for PPARγ, thus affecting PPARγ-dependent gene expression and causing agonism, or an increase in gene expression in the absence of a full agonist, and causing antagonism, or a decrease in gene expression in the presence of a full agonist. However, luteolin uniquely acts as a full agonist for the gene expression of insulin dependent glucose transporters (GLUT-4) in the 3 T3-L1 mouse cell model [4]. Currently it is unclear if this effect is also seen in humans, however it is a potential target for future research. Luteolin also has an effect on inflammation through its effect on proinflammatory cytokines such as interleukin-8 (IL-8) [4]. Although the clinical implications are still unclear for luteolin, recent studies have started to uncover some of the potential beneficial effects it may have. In an in vitro study in human intestinal cells, luteolin has shown to prevent the damage caused by chemotherapeutic treatment. As for the sources of luteolin, luteolin has been shown to be present in marjoram, sage, rosemary, tarragon, thyme, parsley, and alfalfa [6, 39].
Similar to luteolin, rosmarinic acid also acts as a partial agonist for PPARγ, allowing for weak agonism in the absence of a full agonist, and antagonism in the presence of a full agonist [6]. Rosmarinic acid has shown to have anti-inflammatory activity in cell culture assays, however its clinical applications should still be further explored and elaborated on. Rosmarinic acid does however have a poor bioavailability, so its application in humans may be limited regardless of its ability to bind to PPARγ [39]. It still has shown activity as a PPARγ ligand though, so it may be worth further investigation. As far as where rosmarinic acid can be found, it is seen in marjoram, oregano, rosemary, sage, thyme, and lavender [6, 39].
Cinnamic acid and cinnamaldehyde work very similarly. Cinnamaldehyde acts as a partial agonist for PPARγ, allowing for weak agonism in the absence of a full agonist, and antagonism in the presence of a full agonist. Cinnamic acid functions in a similar way, but with a much higher binding affinity for PPARγ [6, 44]. They have both shown a plethora of beneficial effects related to its effect on PPARγ. These include, but are not limited to reducing amyloid-β plaques in Alzheimer’s disease, anti-inflammatory effects, as well as improving glucose and lipid levels as well as insulin sensitivity in Diabetes [39, 44, 45]. Although not all of these effects have been shown in humans yet, some have, and there is great potential for clinical application of cinnamaldehyde. As far as the sources of cinnamaldehyde and cinnamic acid, they can both be found in cinnamon as well as clove [6, 39].
Similar to luteolin, resveratrol also acts as a partial agonist for PPARγ-dependent gene expression, which leads to slight agonism in the absence of a full agonist, and antagonism in the presence of a full agonist. Resveratrol affects both glucose and lipid metabolism, and can also have an effect on inflammation in animal models. Resveratrol has also been shown to improve insulin sensitivity in human patients, which is a contributing factor for Type 2 Diabetes, and can help in control of that disease state beyond metabolism of foods consumed. These mechanisms indicate Resveratrol as potentially beneficial in patients with Type 2 Diabetes, as it can help with glucose metabolism, insulin action, and the storage of fat, potentially lowering their risk of cardiovascular events associated with fats [4]. As for the sources of resveratrol, resveratrol has been shown to be present in foods such as bilberries (European blueberries), grapes, wines, and peanuts [5, 6].
Quercetin acts as a partial agonist for PPARγ-dependent gene expression, causing agonism, or an increase in gene expression in the absence of a full agonist, and causing antagonism, or a decrease in gene expression in the presence of a full agonist [4, 6]. Quercetin has also been shown in a mouse fibroblast cell model (3 T3-L1), that it promotes glucose uptake through insulin-dependent glucose transporters (GLUT-4), however does not affect the production of lipid stores through adipogenesis [4]. Additionally quercetin has shown anti-inflammatory effects in vivo, and is very similar in this regard to resveratrol [4, 39, 46, 47]. Quercetin is also fairly abundant in food sources, and can be found in dill, bay leaves, oregano, pomegranate fruit, apples, tarragon, parsley, chive, and lovage [6, 39].
Catechin too binds to PPARγ, however unlike the previous compounds mentioned, catechin acts as a full agonist for PPARγ-dependent gene expression, and as such does not provide antagonism [4]. This being said, the effects of catechin are expected to differ from the other compounds mentioned previously. One of these differences seen is that the negative enantiomer of catechin promotes the differentiation of mesenchymal stem cells into adipocytes, or fat cells [40]. Alternatively, the positive enantiomer of catechin has anti-inflammatory properties, similar to those previously mentioned [41]. Altogether, both enantiomers of catechin appear to have beneficial effects in terms of health, and both appear to affect the PPARγ pathways. Additionally, the sources of catechin are plentiful, as it can be found in apples, marjoram, sage, rosemary, cinnamon, pomegranate fruit, cacao, green tea, grapes, apricots, and cherries [4, 6, 40, 41].
Although the activities of eugenol through PPARγ are not yet well-defined, it is known to bind to PPARγ with a greater affinity than that of catechin, which acts as a full agonist [4, 6]. Eugenol is also a compound that has been demonstrated to increase insulin sensitivity, and has seen use in essential oils for that purpose [39]. Eugenol has also shown anti-inflammatory effects, like all of the other compounds discussed in this chapter [39]. As for where eugenol is found though, it is seen mostly in clove and cinnamon [6, 39].
Ethyl cinnamate is very similar to cinnamic acid and cinnamaldehyde. It too works similarly in terms of agonism, but has a binding affinity more similar to that of cinnamic acid as opposed to cinnamaldehyde [6]. Additionally, as a PPARγ agonist, it shows the same anti-inflammatory effects that all of the other compounds previously mentioned exhibit [39]. In terms of food sources for ethyl cinnamate though, it is seen in mainly cinnamon and clove [6, 39].
Epicatechin is very similar to the compound discussed earlier, catechin. They both have great binding affinities for PPARγ, and have very similar effects [6]. Like catechin, epicatechin has anti-inflammatory properties. However unlike catechin, epicatechin has also been shown to inhibit PPARγ signaling as well as adipogenesis, or the development of fat stores. Altogether, epicatechin has many positive effects, whether related to its actions on PPARγ, or it’s other bioactivities, and has great promise for medicinal application [42, 43]. In terms of sources of epicatechin, it can be found most prominently in cacao, but also in tea, cinnamon, thyme, apples, grapes, and many other fruits and vegetables [6, 42, 43].
3. Conclusion
As presented there are several natural sources of PPARγ ligands found in spices and food that are commonly consumed. The degree of activation varies on whether the ligand acts as a full agonist or simply as a partial agonist. Molecules that demonstrate a low binding affinity, less than 100 μM, include apigenin, 2-hydoxylchalcone, luteolin, rosmarinic acid, cinnamaldehyde and cinnamic acid, resveratrol and quercetin. Those with moderate binding affinities of 100 to 500 μM, are catechin and eugenol. Those with higher binding affinities include ethylcinnamate and epicatechin. It is important to note that many of these compounds have also been shown to interact in other signaling pathways in the body that could lead to an altered therapeutic response. Together these provide a variety of sources to treat diseases related to PPARγ activity such as inflammation, diabetes, and heart disease.
Conflict of interest
The authors declare no conflict of interest.
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The discovery of food based PPARγ ligands have allowed the exploration of natural treatment of a variety of diseases with potentially fewer side effects due to the ligand based activation rather than full activation. Here we present background on the PPARγ transcription factors and summarize several compounds and the food sources that have demonstrated therapeutic potential for disease states including diabetes, cancer, and cardiovascular disease.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/81505",risUrl:"/chapter/ris/81505",signatures:"Amy L. 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New England Journal of Medicine. 2007;356(24):2457-2471. DOI: 10.1056/NEJMoa072761'},{id:"B38",body:'Home PD, Pocock SJ, Beck-Nielsen H, Gomis R, Hanefeld M, Jones NP, et al. Rosiglitazone evaluated for cardiovascular outcomes — An interim analysis. New England Journal of Medicine. 2007;357(1):28-38. DOI: 10.1056/NEJMoa073394'},{id:"B39",body:'Jungbauer A, Medjakovic S. Anti-inflammatory properties of culinary herbs and spices that ameliorate the effects of metabolic syndrome. Maturitas. 2012;71(3):227-239. DOI: 10.1016/j.maturitas.2011.12.009'},{id:"B40",body:'Shin DW, Kim SN, Fau-Lee SM, Lee SM, Fau-Lee W, Lee W, Fau-Song MJ, Song MJ, Fau-Park SM, Park SM, Fau-Lee TR, et al. (−)-Catechin promotes adipocyte differentiation in human bone marrow mesenchymal stem cells through PPAR gamma transactivation. Biochemical Pharmacology. 2009;77(1):125-133. DOI: 10.1016/j.bcp.2008.09.033'},{id:"B41",body:'Sipahi H, Gostner JM, Becker K, Charehsaz M, Kirmizibekmez H, Schennach H, et al. Bioactivites of two common polyphenolic compounds: Verbascoside and catechin. Pharmaceutical Biology. 2016;54(4):712-729. DOI: 10.3109/13880209.2015.1072830'},{id:"B42",body:'Esser D, Geleijnse JM, Matualatupauw JC, Dower JI, Kromhout D, Hollman PCH, et al. Pure flavonoid epicatechin and whole genome gene expression profiles in circulating immune cells in adults with elevated blood pressure: A randomised double-blind, placebo-controlled, crossover trial. PloS. 2018;13:1-15. DOI: 10.1371/journal.pone.0194229'},{id:"B43",body:'Vazquez-Prieto MA, Bettaieb A, Fau-Haj FG, Haj FG, Fau-Fraga CG, Fraga CG, Fau-Oteiza PI, Oteiza PI. (−)-Epicatechin prevents TNFα-induced activation of signaling cascades involved in inflammation and insulin sensitivity in 3T3-L1 adipocytes. Archives of Biochemistry and Biophysics. 2012;527(2):113-118. DOI: 10.1016/j.abb.2012.02.019'},{id:"B44",body:'Li JE, Futawaka K, Yamamoto H, Kasahara M, Tagami T, Liu TH, et al. Cinnamaldehyde Contributes to Insulin Sensitivity by Activating PPARδ, PPARγ, and RXR. American Journal of Chinese Medicine. 2015;43(5):879-892. DOI: 10.1142/s0192415x15500512'},{id:"B45",body:'Do J, Kim N, Jeon SH, Gee MS, Ju YJ, Kim JA-O, et al. Trans-Cinnamaldehyde Alleviates Amyloid-Beta Pathogenesis via the SIRT1-PGC1α-PPARγ Pathway in 5XFAD Transgenic Mice. International Journal of Molecular Sciences. 2020;21(12):1-13. DOI: 10.3390/ijms21124492'},{id:"B46",body:'Comalada M, Camuesco D, Fau-Sierra S, Sierra S, Fau-Ballester I, Ballester I, Fau-Xaus J, Xaus J, Fau-Gálvez J, Gálvez J, Fau-Zarzuelo A, et al. In vivo quercitrin anti-inflammatory effect involves release of quercetin, which inhibits inflammation through down-regulation of the NF-kappaB pathway. European Journal of Immunology. 2005;35(2):584-592. 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Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. 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His research interests include epidemiological patterns and molecular analysis of antimicrobial resistance and modulation and vaccine development against animal pathogens of public health concern.",institutionString:"Cholistan University of Veterinary and Animal Sciences",institution:{name:"University of Agriculture Faisalabad",country:{name:"Pakistan"}}},{id:"333753",title:"Dr.",name:"Rais",middleName:null,surname:"Ahmed",slug:"rais-ahmed",fullName:"Rais Ahmed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333753/images/20168_n.jpg",biography:null,institutionString:null,institution:{name:"University of Agriculture Faisalabad",country:{name:"Pakistan"}}},{id:"62900",title:"Prof.",name:"Fethi",middleName:null,surname:"Derbel",slug:"fethi-derbel",fullName:"Fethi Derbel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/62900/images/system/62900.jpeg",biography:"Professor Fethi Derbel was born in 1960 in Tunisia. He received his medical degree from the Sousse Faculty of Medicine at Sousse, University of Sousse, Tunisia. He completed his surgical residency in General Surgery at the University Hospital Farhat Hached of Sousse and was a member of the Unit of Liver Transplantation in the University of Rennes, France. He then worked in the Department of Surgery at the Sahloul University Hospital in Sousse. Professor Derbel is presently working at the Clinique les Oliviers, Sousse, Tunisia. His hospital activities are mostly concerned with laparoscopic, colorectal, pancreatic, hepatobiliary, and gastric surgery. He is also very interested in hernia surgery and performs ventral hernia repairs and inguinal hernia repairs. He has been a member of the GREPA and Tunisian Hernia Society (THS). During his residency, he managed patients suffering from diabetic foot, and he was very interested in this pathology. For this reason, he decided to coordinate a book project dealing with the diabetic foot. Professor Derbel has published many articles in journals and collaborates intensively with IntechOpen Access Publisher as an editor.",institutionString:"Clinique les Oliviers",institution:null},{id:"300144",title:"Dr.",name:"Meriem",middleName:null,surname:"Braiki",slug:"meriem-braiki",fullName:"Meriem Braiki",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/300144/images/system/300144.jpg",biography:"Dr. Meriem Braiki is a specialist in pediatric surgeon from Tunisia. She was born in 1985. She received her medical degree from the University of Medicine at Sousse, Tunisia. She achieved her surgical residency training periods in Pediatric Surgery departments at University Hospitals in Monastir, Tunis and France.\r\nShe is currently working at the Pediatric surgery department, Sidi Bouzid Hospital, Tunisia. Her hospital activities are mostly concerned with laparoscopic, parietal, urological and digestive surgery. She has published several articles in diffrent journals.",institutionString:"Sidi Bouzid Regional Hospital",institution:null},{id:"229481",title:"Dr.",name:"Erika M.",middleName:"Martins",surname:"de Carvalho",slug:"erika-m.-de-carvalho",fullName:"Erika M. de Carvalho",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229481/images/6397_n.jpg",biography:null,institutionString:null,institution:{name:"Oswaldo Cruz Foundation",country:{name:"Brazil"}}},{id:"186537",title:"Prof.",name:"Tonay",middleName:null,surname:"Inceboz",slug:"tonay-inceboz",fullName:"Tonay Inceboz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/186537/images/system/186537.jfif",biography:"I was graduated from Ege University of Medical Faculty (Turkey) in 1988 and completed his Med. PhD degree in Medical Parasitology at the same university. I became an Associate Professor in 2008 and Professor in 2014. I am currently working as a Professor at the Department of Medical Parasitology at Dokuz Eylul University, Izmir, Turkey.\n\nI have given many lectures, presentations in different academic meetings. I have more than 60 articles in peer-reviewed journals, 18 book chapters, 1 book editorship.\n\nMy research interests are Echinococcus granulosus, Echinococcus multilocularis (diagnosis, life cycle, in vitro and in vivo cultivation), and Trichomonas vaginalis (diagnosis, PCR, and in vitro cultivation).",institutionString:"Dokuz Eylül University",institution:{name:"Dokuz Eylül University",country:{name:"Turkey"}}},{id:"71812",title:"Prof.",name:"Hanem Fathy",middleName:"Fathy",surname:"Khater",slug:"hanem-fathy-khater",fullName:"Hanem Fathy Khater",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/71812/images/1167_n.jpg",biography:"Prof. Khater is a Professor of Parasitology at Benha University, Egypt. She studied for her doctoral degree, at the Department of Entomology, College of Agriculture, Food and Natural Resources, University of Missouri, Columbia, USA. She has completed her Ph.D. degrees in Parasitology in Egypt, from where she got the award for “the best scientific Ph.D. dissertation”. She worked at the School of Biological Sciences, Bristol, England, the UK in controlling insects of medical and veterinary importance as a grant from Newton Mosharafa, the British Council. Her research is focused on searching of pesticides against mosquitoes, house flies, lice, green bottle fly, camel nasal botfly, soft and hard ticks, mites, and the diamondback moth as well as control of several parasites using safe and natural materials to avoid drug resistances and environmental contamination.",institutionString:null,institution:{name:"Banha University",country:{name:"Egypt"}}},{id:"99780",title:"Prof.",name:"Omolade",middleName:"Olayinka",surname:"Okwa",slug:"omolade-okwa",fullName:"Omolade Okwa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/99780/images/system/99780.jpg",biography:"Omolade Olayinka Okwa is presently a Professor of Parasitology at Lagos State University, Nigeria. She has a PhD in Parasitology (1997), an MSc in Cellular Parasitology (1992), and a BSc (Hons) Zoology (1990) all from the University of Ibadan, Nigeria. She teaches parasitology at the undergraduate and postgraduate levels. She was a recipient of a Commonwealth fellowship supported by British Council tenable at the Centre for Entomology and Parasitology (CAEP), Keele University, United Kingdom between 2004 and 2005. She was awarded an Honorary Visiting Research Fellow at the same university from 2005 to 2007. \nShe has been an external examiner to the Department of Veterinary Microbiology and Parasitology, University of Ibadan, MSc programme between 2010 and 2012. She is a member of the Nigerian Society of Experimental Biology (NISEB), Parasitology and Public Health Society of Nigeria (PPSN), Science Association of Nigeria (SAN), Zoological Society of Nigeria (ZSN), and is Vice Chairperson of the Organisation of Women in Science (OWSG), LASU chapter. She served as Head of Department of Zoology and Environmental Biology, Lagos State University from 2007 to 2010 and 2014 to 2016. She is a reviewer for several local and international journals such as Unilag Journal of Science, Libyan Journal of Medicine, Journal of Medicine and Medical Sciences, and Annual Research and Review in Science. \nShe has authored 45 scientific research publications in local and international journals, 8 scientific reviews, 4 books, and 3 book chapters, which includes the books “Malaria Parasites” and “Malaria” which are IntechOpen access publications.",institutionString:"Lagos State University",institution:{name:"Lagos State University",country:{name:"Nigeria"}}},{id:"273100",title:"Dr.",name:"Vijay",middleName:null,surname:"Gayam",slug:"vijay-gayam",fullName:"Vijay Gayam",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/273100/images/system/273100.jpeg",biography:"Dr. Vijay Bhaskar Reddy Gayam is currently practicing as an internist at Interfaith Medical Center in Brooklyn, New York, USA. He is also a Clinical Assistant Professor at the SUNY Downstate University Hospital and Adjunct Professor of Medicine at the American University of Antigua. He is a holder of an M.B.B.S. degree bestowed to him by Osmania Medical College and received his M.D. at Interfaith Medical Center. His career goals thus far have heavily focused on direct patient care, medical education, and clinical research. He currently serves in two leadership capacities; Assistant Program Director of Medicine at Interfaith Medical Center and as a Councilor for the American\r\nFederation for Medical Research. As a true academician and researcher, he has more than 50 papers indexed in international peer-reviewed journals. He has also presented numerous papers in multiple national and international scientific conferences. His areas of research interest include general internal medicine, gastroenterology and hepatology. He serves as an editor, editorial board member and reviewer for multiple international journals. His research on Hepatitis C has been very successful and has led to multiple research awards, including the 'Equity in Prevention and Treatment Award” from the New York Department of Health Viral Hepatitis Symposium (2018) and the 'Presidential Poster Award” awarded to him by the American College of Gastroenterology (2018). He was also awarded 'Outstanding Clinician in General Medicine” by Venus International Foundation for his extensive research expertise and services, perform over and above the standard expected in the advancement of healthcare, patient safety and quality of care.",institutionString:"Interfaith Medical Center",institution:{name:"Interfaith Medical Center",country:{name:"United States of America"}}},{id:"93517",title:"Dr.",name:"Clement",middleName:"Adebajo",surname:"Meseko",slug:"clement-meseko",fullName:"Clement Meseko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/93517/images/system/93517.jpg",biography:"Dr. Clement Meseko obtained DVM and PhD degree in Veterinary Medicine and Virology respectively. He has worked for over 20 years in both private and public sectors including the academia, contributing to knowledge and control of infectious disease. Through the application of epidemiological skill, classical and molecular virological skills, he investigates viruses of economic and public health importance for the mitigation of the negative impact on people, animal and the environment in the context of Onehealth. \r\nDr. Meseko’s field experience on animal and zoonotic diseases and pathogen dynamics at the human-animal interface over the years shaped his carrier in research and scientific inquiries. He has been part of the investigation of Highly Pathogenic Avian Influenza incursions in sub Saharan Africa and monitors swine Influenza (Pandemic influenza Virus) agro-ecology and potential for interspecies transmission. He has authored and reviewed a number of journal articles and book chapters.",institutionString:"National Veterinary Research Institute",institution:{name:"National Veterinary Research Institute",country:{name:"Nigeria"}}},{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",country:{name:"India"}}},{id:"94928",title:"Dr.",name:"Takuo",middleName:null,surname:"Mizukami",slug:"takuo-mizukami",fullName:"Takuo Mizukami",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94928/images/6402_n.jpg",biography:null,institutionString:null,institution:{name:"National Institute of Infectious Diseases",country:{name:"Japan"}}},{id:"233433",title:"Dr.",name:"Yulia",middleName:null,surname:"Desheva",slug:"yulia-desheva",fullName:"Yulia Desheva",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/233433/images/system/233433.png",biography:"Dr. Yulia Desheva is a leading researcher at the Institute of Experimental Medicine, St. Petersburg, Russia. She is a professor in the Stomatology Faculty, St. Petersburg State University. She has expertise in the development and evaluation of a wide range of live mucosal vaccines against influenza and bacterial complications. Her research interests include immunity against influenza and COVID-19 and the development of immunization schemes for high-risk individuals.",institutionString:'Federal State Budgetary Scientific Institution "Institute of Experimental Medicine"',institution:null},{id:"238958",title:"Mr.",name:"Atamjit",middleName:null,surname:"Singh",slug:"atamjit-singh",fullName:"Atamjit Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/238958/images/6575_n.jpg",biography:null,institutionString:null,institution:null},{id:"252058",title:"M.Sc.",name:"Juan",middleName:null,surname:"Sulca",slug:"juan-sulca",fullName:"Juan Sulca",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252058/images/12834_n.jpg",biography:null,institutionString:null,institution:null},{id:"191392",title:"Dr.",name:"Marimuthu",middleName:null,surname:"Govindarajan",slug:"marimuthu-govindarajan",fullName:"Marimuthu Govindarajan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/191392/images/5828_n.jpg",biography:"Dr. M. Govindarajan completed his BSc degree in Zoology at Government Arts College (Autonomous), Kumbakonam, and MSc, MPhil, and PhD degrees at Annamalai University, Annamalai Nagar, Tamil Nadu, India. He is serving as an assistant professor at the Department of Zoology, Annamalai University. His research interests include isolation, identification, and characterization of biologically active molecules from plants and microbes. He has identified more than 20 pure compounds with high mosquitocidal activity and also conducted high-quality research on photochemistry and nanosynthesis. He has published more than 150 studies in journals with impact factor and 2 books in Lambert Academic Publishing, Germany. He serves as an editorial board member in various national and international scientific journals.",institutionString:null,institution:null},{id:"274660",title:"Dr.",name:"Damodar",middleName:null,surname:"Paudel",slug:"damodar-paudel",fullName:"Damodar Paudel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/274660/images/8176_n.jpg",biography:"I am DrDamodar Paudel,currently working as consultant Physician in Nepal police Hospital.",institutionString:null,institution:null},{id:"241562",title:"Dr.",name:"Melvin",middleName:null,surname:"Sanicas",slug:"melvin-sanicas",fullName:"Melvin Sanicas",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/241562/images/6699_n.jpg",biography:null,institutionString:null,institution:null},{id:"117248",title:"Dr.",name:"Andrew",middleName:null,surname:"Macnab",slug:"andrew-macnab",fullName:"Andrew Macnab",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of British Columbia",country:{name:"Canada"}}},{id:"322007",title:"Dr.",name:"Maria Elizbeth",middleName:null,surname:"Alvarez-Sánchez",slug:"maria-elizbeth-alvarez-sanchez",fullName:"Maria Elizbeth Alvarez-Sánchez",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universidad Autónoma de la Ciudad de México",country:{name:"Mexico"}}},{id:"337443",title:"Dr.",name:"Juan",middleName:null,surname:"A. 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Novel computational algorithms for image analysis, scene understanding, biometrics, deep learning and their software or hardware implementations for natural and medical images, robotics, VR/AR, applications are some research directions relevant to this topic.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/24.jpg",hasOnlineFirst:!0,hasPublishedBooks:!1,annualVolume:11420,editor:{id:"294154",title:"Prof.",name:"George",middleName:null,surname:"Papakostas",slug:"george-papakostas",fullName:"George Papakostas",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002hYaGbQAK/Profile_Picture_1624519712088",biography:"George A. Papakostas has received a diploma in Electrical and Computer Engineering in 1999 and the M.Sc. and Ph.D. degrees in Electrical and Computer Engineering in 2002 and 2007, respectively, from the Democritus University of Thrace (DUTH), Greece. Dr. Papakostas serves as a Tenured Full Professor at the Department of Computer Science, International Hellenic University, Greece. Dr. Papakostas has 10 years of experience in large-scale systems design as a senior software engineer and technical manager, and 20 years of research experience in the field of Artificial Intelligence. Currently, he is the Head of the “Visual Computing” division of HUman-MAchines INteraction Laboratory (HUMAIN-Lab) and the Director of the MPhil program “Advanced Technologies in Informatics and Computers” hosted by the Department of Computer Science, International Hellenic University. He has (co)authored more than 150 publications in indexed journals, international conferences and book chapters, 1 book (in Greek), 3 edited books, and 5 journal special issues. His publications have more than 2100 citations with h-index 27 (GoogleScholar). His research interests include computer/machine vision, machine learning, pattern recognition, computational intelligence. \nDr. Papakostas served as a reviewer in numerous journals, as a program\ncommittee member in international conferences and he is a member of the IAENG, MIR Labs, EUCogIII, INSTICC and the Technical Chamber of Greece (TEE).",institutionString:null,institution:{name:"International Hellenic University",institutionURL:null,country:{name:"Greece"}}},editorTwo:null,editorThree:null,series:{id:"14",title:"Artificial Intelligence",doi:"10.5772/intechopen.79920",issn:"2633-1403"},editorialBoard:[{id:"1177",title:"Prof.",name:"António",middleName:"J. 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\r\n\tIn general, the harsher the environmental conditions in an ecosystem, the lower the biodiversity. Changes in the environment caused by human activity accelerate the impoverishment of biodiversity.
\r\n
\r\n\tBiodiversity refers to “the variability of living organisms from any source, including terrestrial, marine and other aquatic ecosystems and the ecological complexes of which they are part; it includes diversity within each species, between species, and that of ecosystems”.
\r\n
\r\n\tBiodiversity provides food security and constitutes a gene pool for biotechnology, especially in the field of agriculture and medicine, and promotes the development of ecotourism.
\r\n
\r\n\tCurrently, biologists admit that we are witnessing the first phases of the seventh mass extinction caused by human intervention. It is estimated that the current rate of extinction is between a hundred and a thousand times faster than it was when man first appeared. The disappearance of species is caused not only by an accelerated rate of extinction, but also by a decrease in the rate of emergence of new species as human activities degrade the natural environment. The conservation of biological diversity is "a common concern of humanity" and an integral part of the development process. Its objectives are “the conservation of biological diversity, the sustainable use of its components, and the fair and equitable sharing of the benefits resulting from the use of genetic resources”.
\r\n
\r\n\tThe following are the main causes of biodiversity loss:
\r\n
\r\n\t• The destruction of natural habitats to expand urban and agricultural areas and to obtain timber, minerals and other natural resources.
\r\n
\r\n\t• The introduction of alien species into a habitat, whether intentionally or unintentionally which has an impact on the fauna and flora of the area, and as a result, they are reduced or become extinct.
\r\n
\r\n\t• Pollution from industrial and agricultural products, which devastate the fauna and flora, especially those in fresh water.
\r\n
\r\n\t• Global warming, which is seen as a threat to biological diversity, and will become increasingly important in the future.
",coverUrl:"https://cdn.intechopen.com/series_topics/covers/40.jpg",keywords:"Ecosystems, Biodiversity, Fauna, Taxonomy, Invasive Species, Destruction of Habitats, Overexploitation of Natural Resources, Pollution, Global Warming, Conservation of Natural Spaces, Bioremediation"},{id:"39",title:"Environmental Resilience and Management",scope:"
\r\n\tThe environment is subject to severe anthropic effects. Among them are those associated with pollution, resource extraction and overexploitation, loss of biodiversity, soil degradation, disorderly land occupation and planning, and many others. These anthropic effects could potentially be caused by any inadequate management of the environment. However, ecosystems have a resilience that makes them react to disturbances which mitigate the negative effects. It is critical to understand how ecosystems, natural and anthropized, including urban environments, respond to actions that have a negative influence and how they are managed. It is also important to establish when the limits marked by the resilience and the breaking point are achieved and when no return is possible. The main focus for the chapters is to cover the subjects such as understanding how the environment resilience works, the mechanisms involved, and how to manage them in order to improve our interactions with