Main contributions of ERP, configurators and SOA to the requirements of ICT mass customization
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Barely three months into the new year and we are happy to announce a monumental milestone reached - 150 million downloads.
\n\nThis achievement solidifies IntechOpen’s place as a pioneer in Open Access publishing and the home to some of the most relevant scientific research available through Open Access.
\n\nWe are so proud to have worked with so many bright minds throughout the years who have helped us spread knowledge through the power of Open Access and we look forward to continuing to support some of the greatest thinkers of our day.
\n\nThank you for making IntechOpen your place of learning, sharing, and discovery, and here’s to 150 million more!
\n\n\n\n\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"8308",leadTitle:null,fullTitle:"Agricultural Economics - Current Issues",title:"Agricultural Economics",subtitle:"Current Issues",reviewType:"peer-reviewed",abstract:"Agricultural Economics - Current Issues is a review of topics related to the economics of agriculture in various parts of the world. It contains a total of seven chapters. These contributions are related to some of the significant current problems facing these regions. The book is divided into four parts. The first part is simply an introduction to the field of agricultural economics. It charts the development of the field from its origin of farm management economics to the current state of a variety of subjects in various parts of the world. In the second section, an issue related to marketing is discussed. This is followed in the third section by an issue related to water resource economics. In the last section the remaining three chapters are devoted to agricultural environment-related topics. All chapters present guidance for policymaking.",isbn:"978-1-78984-050-6",printIsbn:"978-1-78984-049-0",pdfIsbn:"978-1-83962-637-1",doi:"10.5772/intechopen.78437",price:119,priceEur:129,priceUsd:155,slug:"agricultural-economics-current-issues",numberOfPages:128,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"138b8e4117a40c74fc41ec72d552fa9f",bookSignature:"Surendra N. Kulshreshtha",publishedDate:"October 30th 2019",coverURL:"https://cdn.intechopen.com/books/images_new/8308.jpg",numberOfDownloads:10513,numberOfWosCitations:8,numberOfCrossrefCitations:9,numberOfCrossrefCitationsByBook:1,numberOfDimensionsCitations:22,numberOfDimensionsCitationsByBook:1,hasAltmetrics:1,numberOfTotalCitations:39,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"September 11th 2018",dateEndSecondStepPublish:"October 30th 2018",dateEndThirdStepPublish:"December 29th 2018",dateEndFourthStepPublish:"March 19th 2019",dateEndFifthStepPublish:"May 18th 2019",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"37057",title:"Dr.",name:"Surendra N.",middleName:null,surname:"Kulshreshtha",slug:"surendra-n.-kulshreshtha",fullName:"Surendra N. Kulshreshtha",profilePictureURL:"https://mts.intechopen.com/storage/users/37057/images/system/37057.jpeg",biography:"Suren(dra) N. Kulshreshtha is currently a professor of agricultural economics at the University of Saskatchewan, Saskatoon, a position he has held for the past 50 years. He joined the University of Saskatchewan in 1969. He has been a Visiting Scientist at the International Institute for Applied Systems Analysis, at Laxenburg, Austria. He has also served various professional societies in capacities such as Editor of the Canadian Journal of Agricultural Economics, and Associate Editor of the Canadian Water Resources Journal. He has also participated in several oversees projects in Indonesia, Zambia and India through the Canadian International Development Agency. On the basis of his contributions to the profession of agricultural economics, the Canadian Society of Agricultural Economics selected him a Fellow of the Canadian Agricultural Economics Society in 2004.",institutionString:"University of Saskatchewan",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"5",totalChapterViews:"0",totalEditedBooks:"3",institution:{name:"University of Saskatchewan",institutionURL:null,country:{name:"Canada"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"304",title:"Urban Agriculture",slug:"urban-agriculture"}],chapters:[{id:"67079",title:"Introductory Chapter: Agricultural Economics",doi:"10.5772/intechopen.86343",slug:"introductory-chapter-agricultural-economics",totalDownloads:1272,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Surendra N. Kulshreshtha",downloadPdfUrl:"/chapter/pdf-download/67079",previewPdfUrl:"/chapter/pdf-preview/67079",authors:[{id:"37057",title:"Dr.",name:"Surendra N.",surname:"Kulshreshtha",slug:"surendra-n.-kulshreshtha",fullName:"Surendra N. Kulshreshtha"}],corrections:null},{id:"64696",title:"Date Palm Value Chain Analysis and Marketing Opportunities for the Gulf Cooperation Council (GCC) Countries",doi:"10.5772/intechopen.82450",slug:"date-palm-value-chain-analysis-and-marketing-opportunities-for-the-gulf-cooperation-council-gcc-coun",totalDownloads:3577,totalCrossrefCites:3,totalDimensionsCites:8,hasAltmetrics:1,abstract:"In order to develop a sustainable date palm production system in the Gulf Cooperation Council (GCC) countries of the Arabian Peninsula, an analysis of the date value chain in these countries was undertaken. Through the mapping of the chain, the overall objective was to identify the processes where values are created and how they are distributed among stakeholders along the entire date palm value chain. The method used in this analysis was based on an assessment of the data gathered from the multi-stakeholder surveys implemented in the three case studies of the GCC countries: Kingdom of Saudi Arabia (KSA), Oman, and Kuwait. The empirical findings reveal several problems and constraints that might affect the future of the GCC date palm sector. Therefore, development of a competitive supply date palm chain (both market and agribusiness development) could provide a greater contribution to the GCC economy if producers paid more attention to marketing of this very important food commodity. Hence, date palm production is no longer a way of life but nowadays is considered as an investment option and source of revenues for many stakeholders if the GCC region.",signatures:"Boubaker Dhehibi, Mohamed Ben Salah and Aymen Frija",downloadPdfUrl:"/chapter/pdf-download/64696",previewPdfUrl:"/chapter/pdf-preview/64696",authors:[{id:"197434",title:"Dr.",name:"Boubaker",surname:"Dhehibi",slug:"boubaker-dhehibi",fullName:"Boubaker Dhehibi"},{id:"268347",title:"Dr.",name:"Mohamed",surname:"Ben Salah",slug:"mohamed-ben-salah",fullName:"Mohamed Ben Salah"},{id:"268348",title:"Dr.",name:"Aymen",surname:"Frija",slug:"aymen-frija",fullName:"Aymen Frija"}],corrections:null},{id:"65227",title:"Effects of Water Scarcity on the Performances of the Agricultural Sector and Adaptation Strategies in Tunisia",doi:"10.5772/intechopen.83568",slug:"effects-of-water-scarcity-on-the-performances-of-the-agricultural-sector-and-adaptation-strategies-i",totalDownloads:1299,totalCrossrefCites:1,totalDimensionsCites:4,hasAltmetrics:1,abstract:"The chapter aims to develop a regionally disaggregated agricultural supply model for Tunisia in order to investigate the potential effects of increasing water scarcity on the performances of the agricultural sector in the country, and the structural adaptation strategies needed to face such a challenge. A set of scenarios combining future water availability, water use efficiency, and increasing producer prices were simulated using the developed model. Results show that the agricultural sector in Tunisia, particularly the agricultural employment, would be negatively affected in case of decreasing irrigation water availability, and mostly affected regions would be the north east, central west, and southern areas. However, it is always possible to mitigate such effects through a combination of structural adjustments (changing land use in different regions), enhanced water use efficiency, and support of producer prices. The model also provides recommendations regarding specific crops that should be promoted in specific regions in order to maintain an agricultural sector with high added value in Tunisia.",signatures:"Ali Chebil, Aymen Frija, Mariem Makhlouf, Chokri Thabet and Sihem Jebari",downloadPdfUrl:"/chapter/pdf-download/65227",previewPdfUrl:"/chapter/pdf-preview/65227",authors:[{id:"268348",title:"Dr.",name:"Aymen",surname:"Frija",slug:"aymen-frija",fullName:"Aymen Frija"},{id:"282705",title:"Ph.D.",name:"Ali",surname:"Chebil",slug:"ali-chebil",fullName:"Ali Chebil"},{id:"283211",title:"Dr.",name:"Mariem",surname:"Makhlouf",slug:"mariem-makhlouf",fullName:"Mariem Makhlouf"},{id:"283212",title:"Dr.",name:"Chokri",surname:"Thabet",slug:"chokri-thabet",fullName:"Chokri Thabet"},{id:"308992",title:"Prof.",name:"Sihem",surname:"Jebari",slug:"sihem-jebari",fullName:"Sihem Jebari"}],corrections:null},{id:"66616",title:"Local Techniques for Crop Conservation in Burkina Faso: Analysis of the Valorization Status and Perception of Tilgr-Baore Technology",doi:"10.5772/intechopen.85179",slug:"local-techniques-for-crop-conservation-in-burkina-faso-analysis-of-the-valorization-status-and-perce",totalDownloads:853,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Agriculture is the main source of income for the poorest people and the pillar of food security in Burkina Faso. However, the producers face the problem of food insecurity each year, due to the effects of climate change and the difficulty of conserving their produce, because of inadequate storage infrastructure. These situations result in the loss of large quantities of products after harvest. Technological advances can provide solutions to this problem of postharvest losses and help many small producers to reduce poverty. Unfortunately, new product conservation techniques implemented in Burkina Faso are less known and poorly adopted. The objective of this chapter is to identify constraints to the valorization of new postharvest technologies of onion and potato and analyze factors influencing farmers’ perception of these innovations. The results of the surveys conducted using the Tilgr-Baore technology show that many agricultural producers are analphabet and not yet aware of the existence of the new product conservation technology. The improvement of the level of education of farmers and the availability of information on innovations are needed to improve the perception of innovations and thus increase the probability of adoption of these innovations.",signatures:"Kala Brigitte Hema, Bienlo Annick Marina Paré and Marie-Thérèse Arcens Somé",downloadPdfUrl:"/chapter/pdf-download/66616",previewPdfUrl:"/chapter/pdf-preview/66616",authors:[{id:"280207",title:"Dr.",name:"Kala Brigitte",surname:"Hema",slug:"kala-brigitte-hema",fullName:"Kala Brigitte Hema"},{id:"289733",title:"MSc.",name:"Bienlo Annick",surname:"Marina Paré",slug:"bienlo-annick-marina-pare",fullName:"Bienlo Annick Marina Paré"},{id:"294842",title:"Dr.",name:"Marie-Thérèse",surname:"Arcens Somé",slug:"marie-therese-arcens-some",fullName:"Marie-Thérèse Arcens Somé"}],corrections:null},{id:"66293",title:"Value Chain-Induced Constraints Limiting Scale of Conservation Agriculture in South Africa",doi:"10.5772/intechopen.84499",slug:"value-chain-induced-constraints-limiting-scale-of-conservation-agriculture-in-south-africa",totalDownloads:812,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The potential of scaling conservation agriculture (CA), for long-term food security, remains under-investigated within the context of agricultural food value chains in South Africa. To scale the use of CA an understanding of the current agricultural value chains, their functioning, regulatory framework and constraints, is essential and this raises a key question: What are the main shortfalls and deterrents in agricultural value chains and why might CA be faced with challenges to feed into these existing structures, through which it could, the hopes are, create a more inclusive and sustainable farming system for long-term food security? The empirical data from an ethnographic qualitative participant research showed that interviewed value chain participants (VCP) are limited in acting on account of their economic constraints. None of them had products that supported CA, while financial institutions argued that such products would not be necessary, as any risk mitigating farming system would, in any event, result in financial benefits to the farmer.",signatures:"Wolfgang Johann von Loeper, Scott Drimie and James Blignaut",downloadPdfUrl:"/chapter/pdf-download/66293",previewPdfUrl:"/chapter/pdf-preview/66293",authors:[{id:"219859",title:"Mr.",name:"Wolfgang Johann",surname:"von Loeper",slug:"wolfgang-johann-von-loeper",fullName:"Wolfgang Johann von Loeper"},{id:"222873",title:"Prof.",name:"James",surname:"Blignaut",slug:"james-blignaut",fullName:"James Blignaut"},{id:"222874",title:"Dr.",name:"Scott",surname:"Drimie",slug:"scott-drimie",fullName:"Scott Drimie"}],corrections:null},{id:"64186",title:"Coastal Community Adaptation to Climate Change-Induced Salinity Intrusion in Bangladesh",doi:"10.5772/intechopen.80418",slug:"coastal-community-adaptation-to-climate-change-induced-salinity-intrusion-in-bangladesh",totalDownloads:1685,totalCrossrefCites:1,totalDimensionsCites:3,hasAltmetrics:1,abstract:"Bangladesh, a country with a size of 147,570 km2, has the largest delta in the world with one-third of the country residing a costal shoreline. The livelihood of the inhabitants is exposed to a series of tribulations causing radical setbacks, of which natural disasters like tropical cyclones bring large-scale salinity intrusion. Occurring due to three main causal factors including climate change, sedimentation, and low water flow, salinity poses challenges in agriculture and overall food security, hence impeding the health and livelihood of marginalized women, children, and elderly and explicably the overall vulnerable population at large. Against that backdrop, this chapter will delineate three broad spectra of Bangladesh’s approach to “living with salt”: (1) the assessment of salt intrusion in water and soil in Bangladesh’s coastal zones due to climate change, (2) understanding the vulnerabilities to salinity within marginalized population, and (3) coping or adapting strategies to combat and live with salt. The chapter also includes the findings of a recent case study conducted on Bangladesh coastal zone to demonstrate the current livelihood conditions under salinity, conditions of the actions taken by the government and nongovernment organizations, gaps, and recommendations for a more resilient coastal community.",signatures:"Golam Rabbani, Sirazoom Munira and Samia Saif",downloadPdfUrl:"/chapter/pdf-download/64186",previewPdfUrl:"/chapter/pdf-preview/64186",authors:[{id:"252937",title:"Mr.",name:"Golam",surname:"Rabbani",slug:"golam-rabbani",fullName:"Golam Rabbani"},{id:"252939",title:"Dr.",name:"Samia",surname:"Saif",slug:"samia-saif",fullName:"Samia Saif"},{id:"252940",title:"Dr.",name:"Sirazoom",surname:"Munira",slug:"sirazoom-munira",fullName:"Sirazoom Munira"}],corrections:null},{id:"69221",title:"Social Value of Urban Rooftop Farming: A Hong Kong Case Study",doi:"10.5772/intechopen.89279",slug:"social-value-of-urban-rooftop-farming-a-hong-kong-case-study",totalDownloads:1015,totalCrossrefCites:4,totalDimensionsCites:7,hasAltmetrics:1,abstract:"As cities densify, areas available for agriculture within the city become increasingly small and infeasible for mass production. In parallel, many cities have seen a rapid rise in establishing community-based micro-farming, operating within marginal spaces of uncertain ownership or regulations. Prominently in Hong Kong, more than 60 urban rooftop farms have spontaneously appeared in the last 10 years on buildings. High application rates for renting plots in these informal farms suggest a strong demand in the population. Motivations cited by participants of rooftop farms are typically social, although social values have yet to be specifically defined or objectively measured. Hong Kong Special Administrative Region Government’s new agricultural policy conceives urban agriculture as a commercially productive practice. In consequence, urban rooftop farming lies awkwardly between formal city planning and informal community practices. A study of five rooftop farms in Hong Kong found, through participant opinion surveys and cost-benefit analysis, that the social benefits to participants were multifaceted with a preference on personal socialization and that they were willing to pay for the experience. The results suggest that if the products of rooftop farming could be conceived as being social, rather than food production, individual motivations and state interests could be aligned and the available roof space activated to achieve a more sustainable city.",signatures:"Ting Wang and Mathew Pryor",downloadPdfUrl:"/chapter/pdf-download/69221",previewPdfUrl:"/chapter/pdf-preview/69221",authors:[{id:"289674",title:"Ph.D. Student",name:"Ting",surname:"Wang",slug:"ting-wang",fullName:"Ting Wang"},{id:"289677",title:"Prof.",name:"Mathew",surname:"Pryor",slug:"mathew-pryor",fullName:"Mathew Pryor"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"5502",title:"Current Perspective on Irrigation and Drainage",subtitle:null,isOpenForSubmission:!1,hash:"f84b58948ba0347cba6ad7d2f1e65fe2",slug:"current-perspective-on-irrigation-and-drainage",bookSignature:"Suren Kulshreshtha and Amin Elshorbagy",coverURL:"https://cdn.intechopen.com/books/images_new/5502.jpg",editedByType:"Edited by",editors:[{id:"37057",title:"Dr.",name:"Surendra N.",surname:"Kulshreshtha",slug:"surendra-n.-kulshreshtha",fullName:"Surendra N. 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Mastering both demand and supply uncertainty is a key challenge for many companies. Markets are increasingly turbulent and also the vulnerability of production and logistics processes is growing. The management of uncertainty has been addressed as an essential task of supply chain management (among others by Davis 1993 and van der Vorst & Beulens 2002).
For coping with the addressed uncertainties, Supply Chain Management (SCM) literature initially has focused on creating so-called lean supply chains that efficiently push products to the market. Lean supply chains build upon reduction of demand uncertainty, especially by product standardisation. Customers must choose from a fixed range of standard products that are made to forecast in high volumes. Business processes in lean supply chains can be highly automated by Enterprise Resource Planning (ERP) systems (Davenport and Brooks, 2004).
In the late 1990s, the then dominant approach of leanness was criticised more and more. It was argued that in volatile markets it is impossible to remove uncertainty. Companies therefore should accept differentiation and unpredictability, and focus on better uncertainty management. Agility was proposed as an alternative approach that aims for rapid response to unpredictable demand in a timely and cost-effective manner (Fisher, 1997, Christopher, 2000). It is founded on a mass customisation approach that combines the seemingly contradictory notions of flexible customisation with efficient standardisation (Davis, 1989, Pine et al., 1993). Efficient standardisation is realised by fabricating parts of the product in volume as standard components; distinctiveness is realised through customer-specific assembly of modules (Duray et al., 2000).
Until then, SCM focused on strategies for coping with demand uncertainty. Lee (2002) was one of the first who stressed the impact of supply uncertainty on supply chain design. Supply chains characterised by high supply uncertainty require the flexibility to deal with unexpected changes in the business processes. Disturbances of logistics, production or supply of materials should rapidly be observed and lead to process changes including re-planning and re-scheduling, purchasing new material, hiring alternative service providers, or negotiating new customer requirements.
Supply chains that are characterised by a high uncertainty of both demand and supply require a combination of responsiveness to changing demand and the flexibility to deal with unexpected changes in the business processes. Following Lee (2002), we use the term agility to characterise these types of supply chains. In agile supply chains, demand requirements and supply capabilities,
The main objectives of this chapter are to define the requirements to information systems in agile supply chains and to develop strategies for implementation of agile information systems. For the identification of requirements, the concept of mass customisation is applied to information systems.
The chapter first introduces a typology of supply chain strategies and the role of information systems in these strategies. Next, it focuses on information systems in the quadrant of agile supply chains. It is argued that these supply chains information systems should support an ICT (information and communications technology) mass customisation approach and the basic requirements for such an approach are defined. In the next section the role of ERP systems, configurators and Service Oriented Architecture (SOA) to enable ICT mass customisation is described. The chapter concludes with the introduction of three basic strategies for the implementation of agile information systems. The strategies involve different divisions of product configuration, process configuration and management of the order fulfilment among ERP systems, dedicated configurator software and SOA platforms.
Fisher (1997) introduced the idea that supply chain design should match the degree of demand uncertainty. Fisher discriminates between functional and innovative products. For functional products, having low demand uncertainty, efficient or lean supply chains perform best. For innovative products, that have a high degree of demand uncertainty, flexible or agile chains are a better match. Lee (2002) extends Fisher’s analysis by adding the dimension of supply uncertainty. Lee distinguishes between stable and evolving supply processes. Stable processes are characterized by controllable production, mature technology and settled industry. In evolving supply processes production and technology are under development and more or less unpredictable.Lee matches four supply chain types with characteristics of supply and demand (see figure 1):
Supply chain strategies and demand and supply characteristics [8](
Efficient supply chains focus on cost reduction and match with low supply uncertainty - i.e. a controllable production process - and low demand uncertainty.
Risk-hedging supply chains focus on pooling resources to reduce supply uncertainty; this type of chain matches with high supply uncertainty and low demand uncertainty.
Responsive supply chains focus on flexibility through make-to-order process and mass customization; they match with low supply uncertainty and high demand uncertainty.
Agile supply chains combine risk-hedging and responsive strategies, aiming to cope with both high supply uncertainty and high demand uncertainty.
The present chapter focuses on agile supply chains. A firm operating in such a supply chain lacks information about future demand and cannot reliably plan the order fulfillment process. After having defined the current position, two types of strategic options for dealing with the accompanying uncertainty can be distinguished: i) uncertainty reduction strategies that focus on decreasing the need for information, and ii) strategies for better management of uncertainties that focus on improving the information processing capacity.
Firstly, a firm should determine whether reduction of uncertainty is possible and desirable. Uncertainty reduction would imply a shift toward efficient, responsive, or risk-hedging supply chains in the framework of Figure 1. Reduction strategies aim to reduce differentiation by standardization and to eliminate the sources of disruptions. Demand-related examples are product standardization, sharing demand information exchange for improved forecasting and establishment of long-term contracts. Supply-related examples of reduction strategies are improved production control, sharing supply information for synchronized planning, cooperation with technology suppliers, hubs for supplier-managed inventory, and production standardization e.g. by fixed batch volumes, standard carriers, or fixed delivery schedules. Reduction of, especially, demand uncertainty - for instance by product standardization and reducing available product options – is not always desirable. In particular this is not desirable for firms that find their market niche in flexibly fulfilling specific customer needs.
Firms that cannot sufficiently reduce supply and demand uncertainties must find ways to manage the uncertainties. Such firms can consider possibilities for uncertainty management, which leave differentiation and unpredictability as is, but aim to manage it by better organization, maintaining close relationships with suppliers and service providers, usage of advanced decision support tools and better utilization of information.
The mentioned strategies show that information systems are important means for uncertainty reduction and uncertainty management. However, in particular agile supply chains entails specific information system needs, as discussed below.
In the 1990s Supply Chain Management (SCM) evolved towards an integrated process approach in which the concepts of logistics management were extended to incorporate the integration of firms in its supply chain. In the beginning, the focus in Supply Chain Management (SCM) was very much on so-called lean supply chains. The origins of lean manufacturing can be traced to the Toyota Production System (TPS), which focuses on the reduction and elimination of waste (Womack et al. 1991). Thus, lean supply chains focus on efficient streamlined pipelines that push raw material to the market in order to supply predictable demand in high volumes at the lowest costs.
During the 1990s the focus on supply chains as static physical pipelines was criticized more and more. In definitions from the Supply Chain Management (SCM) literature, the network character of supply chains was emphasized (among others by Christopher 1998): “A Supply Chain is the network of organizations that are involved, through upstream and downstream linkages, in the different processes and activities that produce value in the form of products and services in the hands of the ultimate consumer.”
The enrichment of the supply chain concept with the network dimension was no conclusive answer to the criticisms on supply chains as static physical pipelines. Also supply chain networks can be focused on the pushing products efficiently to the ultimate customers. As a consequence, in the beginning of this century there was an intensive debate in the SCM-field on agility as an alternative for the then dominant approach of leanness (Christopher 2000). It was argued that a fundamental shift was required in the dominant underlying approach. According to Christopher (2000), the lengthy and slow-moving “pipelines” have become unsustainable due to the turbulence and volatility of current marketplaces. He suggests that the key to survival in these changed conditions is through “agility”, in particular by the creation of responsive supply chains that are market sensitive.
Agility can be defined as “using market knowledge and virtual corporation to exploit profitable opportunities in a volatile market place” (Naylor et al. 1999). Agile supply chains are required to be market sensitive and hence nimble (Christopher and Towill 2000). The primary purpose of responsive chains is to respond quickly to unpredictable demand in order to minimize stock outs, forced markdowns and obsolete inventory (Fisher 1997). This thinking is based on dynamics of business systems, which has been a major issue in management research for a long time, while the concept of agility can be traced back to (Goldman et al. 1995).
From the debate emerged that both leanness and agility are no mutually exclusive strategies. On a strategic level it is a matter of strategic choice (as argued yet by Fisher 1997). There is no one best chain network design (‘one size fits all’), but companies continuously have to decide in which supply chain they want to participate, which role they are able to play the best and how they deliver added value in these networks. Furthermore, on an operational level it is always a balancing process between push and pull elements (Naylor et al. 1999; Mason-Jones et al. 2000). Nevertheless, there is a trend towards more agile supply chains because of increasing demand and supply uncertainty.
Supply chain management aims to manage the complex of business processes performed by numerous interdependent supply chain actors as an integrated whole.Information systems are vital to make the resulting complex, frequent and inter-enterprise information flows manageable by offering tools to automatically capture, process, transfer and communicate information in the supply chain. They can support the planning, control and coordinationof supply chains in the following aspects:
Communication of goals, plans and orders based on actual demand and supply information;
Assurance of the required process execution by triggering the right activities and guiding the appropriate usage of resources and material (instructions);
Continuous and chain-wide registration of monitoring information and effective alert mechanisms;
Rapid and integrated decision-making based on aggregated and enriched monitoring information and information about external variables;
Fast communication and implementation of the decided corrective and preventive actions.
As a consequence, one can distinguish between the following roles of information systems in Supply Chain Management (Verdouw et al., 2005b):
Platform for shared communication: to enable integration of control activities in supply chains, there should be in the first place an integrated technical information infrastructure. This requires an effective integration of the information systems of the individual chain actors, with respect to the information definitions, data exchange, applications and technical infrastructure. Examples of enabling ICT are:
Inter-organizational technical communication infrastructures, including the Internet and Virtual Private Networks;
EDI/XML based techniques for data exchange;
Enterprise Application Integration (EAI): software to integrate the applications of individual chain actors, nowadays based on service-oriented architecture (SOA);
Central, mostly web based information systems that are used by all involved supply chain actors to manage the basic information flow;
Exchange of demand and supply information: if there is a shared information infrastructure in place, demand and supply information can be communicated in the entire supply chain. ICT can help to capture this information, translate it to the involved chain actors and integrate it with the back office systems. Examples of enabling ICT are:
Product configuration tools that help to specify customer specific orders in interaction with the customer within the process constraints (guided selling) and convert generated customer orders automatically into detailed production, sourcing or distribution orders;
Point of Sales (POS) applications that help to replenish retail stocks on basis of actual consumer transactions;
Integrated Planning Systems (CPFR: Collaborative Forecasting Planning and Replenishment), in which the planning of the involved companies is aligned;
Management of supply chain process execution: the triggering, guiding and registration of customer specific task execution, including early detecting and signalling of (potential) disturbances. Examples of enabling ICT are:
Enterprise software for production management, distribution, warehouse management, sales, purchase and finance (ERP systems);
Early Warning Systems that continuously measure the process conditions and alert if there is serious risk based on an intelligent reaction on condition changes;
Inter-organisational Management Information Systems that translate the basis process information into high-level management information about the realization of Performance Indicators, often in the form of management cockpits or dashboards;
Decision support: tools to analyse demand and supply information and information about process fulfilment, determine the alternatives of corrective and preventive action and to compare and advice about the best solution. Examples of enabling ICT are:
Demand Forecasting Models that help to analyse consumer behaviour e.g. on basis of Point of Sales data and predict future consumer demand in order to improve planning;
Chain Process Simulation Models, that analyse the process behaviour in various levels of demand orientation and help to improve the fulfilment of consumer demand;
Process configuration and implementation: the adjustment of control variables and the supporting information systems in order to support customer-specific process execution. Vital enabling element is the ability to configure and reconfigure ICT rapidly. Furthermore, ICT can support the required changes in human behaviour, e.g. by stimulating problem awareness (diagnosis tools), vision development (gaming and simulation) and intervention design (Verdouw et al. 2005a).
A firm’s information systems should match the type of supply chain it operates in. For further analysis we distinguish between front-office systems (coping with the demand side) and back-office systems (coping with the supply side). Front-office systems include order management, contract management, sales configurator, demand forecasting, and customer relations management systems. Back-office systems include resource planning and scheduling, stock management, purchasing, and supplier relations management systems. The type of supply chain determines the required flexibility of front- and back-office systems (Verdouw & Verwaart 2008):
Efficient supply chains require stable, straight-forward planning systems for both front-office and back-office. The systems must be well-integrated to reduce waste of resources. Back-office systems support large volume production of standardized products based on long-run forecasts. Front-office systems support efficient order processing, long-run contracts and demand forecasts. Traditional ERP systems cover the demands of efficient supply chains.
Risk-hedgingsupply chains require the same type of stable front-office systems as efficient supply chains do. However, they require flexible back-office systems, integrated with production control systems and supplier’s systems. Disturbance of production or supply of materials should rapidly be observed and lead to re-planning and rescheduling. The rigid planning and scheduling systems of traditional ERP systems may cause problems in this type of supply chain.
Responsivesupply chains place high demands on the ability to combine fluctuations in demand and available supplies with respect to product specifications and lead times. The most common approach to organize responsiveness is mass customization in an assemble-to-order (ATO) production environment. This type of supply chain quickly responses to demand variability by efficient assembling of order-specific products from standard components. It requires stable back-office systems for efficient production of standardized components and rapid assembly. Traditional ERP systems can meet this demand. However, front-office systems require a flexibility usually not offered by traditional ERP systems. A responsive supply chain may require a more sophisticated sales configurator.
Agilesupply chains require flexibility in both front-office and back-office systems. They demand flexible ERP in the back-office and sophisticated configurator and customer communications systems in the front-office. Tight integration is required between front-office and back-office and with systems of both suppliers and customers.
This section focuses on the requirements for information systems in agile supply chains. Therefore, it applies the concept of mass customisation to information systems.
In agile supply chains, it must be possible to easily set-up, connect and disconnect information systems needed to achieve a specific value proposition. It must be possible to design and instantiate new or adjusted supply chain configurations rapidly and at low costs. The main challenge in achieving this is to combine flexible customization with efficient standardization in the design and implementation of the logistics information systems introduced above. Mass customization is broadly advocated as a core approach to balance these seemingly contradictory notions (Davis 1989; Pine et al. 1993; Kotha 1995). It is a modular strategy that is intended to accomplish efficiency by reusing standardized components, while achieving distinctiveness through customer-specific assembly of modules (Lampel and Mintzberg, 1996, Duray et al., 2000). Mass-customisation builds on four operational capabilities: i) common building blocks that can be reused maximally, ii) unified architecture providing a structure of the defined components that constrain possible variants, iii) a technical platform for seamless integration of the building blocks, and iv) configuration tools that support the elicitation of customer requirements while considering the possible options (Pine et al. 1993, Duray et al. 2000, Zipkin 2000, Verdouw et al., 2010a, among others).
ICT mass customisation combines the seemingly contradictory notions of efficient standard software and flexible customised software (Verdouw et al., 2010b). It enables customer-specific assembly of information systems from a repository of standard components. As such, mass-customisable ICT can be positioned in the middle of a continuum of standard packaged software and customised software. Software developers pre-design and realise modules based on forecasted functionality. Customers get their own ICT configuration, but constrained by the range of available components, as defined in reference models for the configuration of systems. These components could be supplied by different software vendors, which allows for using best-of-breed solutions in selecting and designing systems.
Following the identified requirements for mass customisation systems, the requirements for mass-customisable information systems are (Verdouw et al., 2010b):
Generic information model: like product architectures in a mass customisation approach, information models should be set up as generic models, which define the class of architectures that can be assembled. Additional complexity of generic information models is that they comprise different interrelated model types including business process models, product models, semantic data models and ontologies, and information integration standards, e.g. eBusiness messages, web service standards, RFID protocols, and coding standards.
Modular software: modules in an ICT mass customisation approach must be application-independent services, in which policy, input and output data, and interfaces are well defined (product modularity). They should not impose technical constraints on development of other modules (process modularity). Furthermore, it should be easy to replace a software module of provider A by a module of provider B, and it must be possible to combine modules of different vendors (network modularity).
Information integration platform: a software platform is required that the modules can easily be plugged into, that can enact the execution of modules upon the occurrence of external or internal events, and that enables the exchange of information between the modules. Contrary to mass-customisable products, this platform has a virtual nature. It is not tied to one place. Especially internet-based techniques enable integration of modules that are located all over the world.
Configuration support: configuration of ICT elicits the required functionality of specific instantiations of information systems building upon a generic information model. Since information systems are composed of many interacting components, ICT configuration must be done for different levels of abstraction and different types of subsystems. Consequently, configuring information systems includes many partial configuration tasks that occur at different moments by different people. The dependencies between these different tasks must be well coordinated.
Component availability: the availability of software modules that, together, provide the desired functionality, including a specification of the interfaces. A specific characteristic of ICT components is again the virtual nature. This implies that components can be duplicated very quickly and at a negligible cost. On the other hand, availability is dependent on service providers, because users have access to the modules via an often complex information infrastructure.
This section identifies three basic strategies for the implementation of agile information systems. The strategies involve different divisions of product configuration, process configuration and management of the order fulfilment among ERP systems, dedicated configurator software and SOA platforms.Therefore, we first will introduce the role of ERP systems, configurators and SOA to enable ICT mass customisation.
An Enterprise Resource Planning (ERP) system is a standardized software package that combines functionality of multiple business functions into one integrated system. It is based on a single database and contains functionality to support the main business processes including production, distribution, warehouse management, sales, purchase and finance. The major advantage of ERP is that it provides a stable backbone for the registration and communication of information among business functions, and consequently ensures the timely and accurate availability for integrated business process management. As such, it helps to overcome fragmentation betweenorganizational units (functional silos) and systems (island automation).
ERP has emerged in the early 1990s as a logical extension of the material requirements planning (MRP) systems of the 1970s and of the manufacturing resource planning (MRP II) systems of the 1980s (Akkermans et al., 2003, Jacobs and Weston, 2007). It has been advocated as essential means for implementation of Business Process Redesign in order to improve efficiency and customer service (Davenport, 2000, Hammer and Champy, 2001). Nowadays, ERP has become a de facto standard in many industries. For example, Aberdeen reported in 2008 that 86% of the manufacturing companies has implemented ERP (Aberdeen, 2008).
Early ERP-systems were not primarily focused on the supply chain (Davenport and Brooks, 2004). Consequently, they failed to meet the demands in current dynamic supply chains. In acritical note, Rettig (2007) argues that the ERP concept of a single monolithic system failed for many companies: “But these massive programs, with millions of lines of code, thousands of installation options and countless interrelated pieces, introduced new levels of complexity, often without eliminating the older systems they were designed to replace.” In a study of Akkermans et al., (2003) European supply chain executives address four key limitations of ERP systems in providing effective supply chain support:
Their insufficient extended enterprise functionality in crossing organizational boundaries;
Their inflexibility to ever-changing supply chain needs;
Their lack of functionality beyond managing transactions; and
Their closed and non-modular system architecture.
Akkermans et al. (2003) argue that the lack of modularity is the root cause for the other shortcomings.
In the research note “ERP is dead – long live ERP II”, Gartner was one of the first who put the limitations of early ERP systems on the agenda (Bond et al., 2000). They defined ERP II as a transformation of ERP into next-generation enterprise systems, which are web based, open and componentised. The ERP industry has embraced this new philosophy and started to modularize their systems architectures, in particular by incorporating Service Oriented Architecture (SOA) platforms, e.g. SAP NetWeaver (Møller, 2005). Furthermore, ERP vendors included intelligent modules that go beyond transactions (especially Advanced Planning Systems and Business Intelligence). However, the monolithic nature is deeply embedded in ERP systems. It takes much time to unravel the big jumble of software code into a consistent and coherent set of components. Consequently, the componentizing of ERP is still in progress. This implies that, although valuable advances are accomplished, the basic limitations of ERP systems still exist.
ERP systems perfectly cover thedemands of efficient supply chains that are characterized by stable business processes and lowdemand uncertainty. However, in supply chains with uncertain demand and high vulnerability ofproduction and logistics processes, current ERP is experienced as an obstacle in achieving therequired flexibility (Akkermans et al., 2003). The development towards modularized and service-oriented ERP is essential for the implementation of mass-customizable information systems. Such ERP systems ensure the availability of the software modules that, together, provide the desired functionality, including a specification of the interfaces. As such modularized ERP can provide a repository of building blocks that form the heart of mass customizable information systems.
Configurators have emerged from the development of rule-based product design in the field of Artificial Intelligence. A well-known early application was R1, a product configurator for VAX computers (Mc Dermott, 1981). A product configurator is a tool that guides users interactively through specification of customer-specific products (Sabin and Weigel, 1998, Forza and Salvador, 2002). Configurators generate specific product variants by combining sets of predefined components and specifying features according to permitted values. Next, they check the completeness and consistency of configured products based on rules that define the interdependencies between components or features. Product configurators are based on generic product models, which define the class of objects that can be configured (Hegge and Wortmann, 1991).
Currently, configurators play an important role in responsive supply chains, which are characterised by high demand uncertainty and low supply uncertainty (Lee, 2002). They are widely used for product configuration to enable rapid response to customer demands. In interaction with the user, the software generates consistent and complete specifications of customised products, taking into account both customer’s requirements (e.g. functional specifications and delivery conditions) and feasibility of production, sourcing and delivery. Along with the product specification, current configurators can produce commercial offers and draft contracts, and schedules and contracts for support and maintenance of the product. The software can be designed for use either by a sales representative of the supplier, or by a customer, e.g. through the internet. In both cases the configuration process results in a quick and effective order specification that can directly be entered into the production planning and scheduling systems.
Configurators can also be used to manage high uncertainties at the supply-side by supporting the rapid configuration of processes (Verdouw et al. 2010a). This concept of process configuration is introduced by Schierholt (2001), who applied the principles of product configuration to support process planning. Process configuration supports a rapid and consistent specification of the workflow that is needed to fulfil specific customer orders. For example, local deliveries from stock follow a different workflow than exports that are produced to order. Moreover, it supports reconfiguration of the workflow in case of unexpected supply events, e.g. components that were originally planned to be produced can be re-planned to be purchased.
Configurators can provide the configuration support as required in mass-customisable information systems. It helps to elicit the required functionality of specific instantiations of information systems building upon a generic information model.
Service-Oriented Architecture (SOA) is a software architecture where functionality is grouped around business processes and packaged as interoperable services. The aim is a loose coupling of services with operating systems, programming languages and other technologies, which underlie applications (Newcomer and Lomow, 2004). SOA separates functions into distinct units, or services (Bell, 2008), which are made accessible over a network to be combined and reused in the production of business applications (Erl, 2005). These services communicate with each other by passing data from one service to another, or by coordinating an activity between two or more services. Service providers publish web services in a service directory, service requestors search in this directory to find suitable services, bind to that service and use it, based on information from the directory and standardized procedures (Leymann, 2003; Erl, 2005). So, SOA provides the technology that enables timely and flexible sharing of information demands (Wolfert et al., 2010). It is component-based by nature and widely acknowledged as the de facto standard for information integration. SOA enables the definition of components with standardized interfaces, a central repository of published web services and standardized procedures for selection and implementation of components.
A technical architecture based on SOA consists of three layers (Erl, 2005):
A business process management layer, coordinating the execution of business services: this is a functional integration layer that groups services from the underlying business service layer into business processes. The process services are typically implemented through generic enactment engines, that execute workflows defined in languages like BPEL or BPML. Following the workflow specifications, the enactment engines invoke services in the next layer. Services in the process layer can be rapidly configured or reconfigured using business process management (BPM) tools.
A business services layer, delivering information services to the business processes. The business services implement the information processing functions of the actual business processes. Business services may be either straightforward data registration or reporting services, or complex services based on extensive business logic. They may implement these functions directly, for instance applying the Business Rules Approach, or use application services that connect the business services to (legacy) information processing application systems.
A business application layer, executing the application logic and data storage. Applications are wrapped in application services, offering a standard web service interface to the business services, thus enabling enterprise application integration (EAI).
The advances towards Service-Oriented Architecture (SOA) has been very important to enable mass-customisation of information systems. It can provide a software platformthat the web services can easily be plugged into, that can enact the execution of web services upon the occurrence of external or internal events, and that enables the exchange of information between the modules. Consequently, it can support to meet, in particular, the requirements concerning software modularity and information integration platform (Verdouw et al., 2010b). As such, SOA can help to overcome the limitations of traditional ERP systems and achieve the required backend flexibility in agile supply chains. However, SOA does not include the knowledge required to specify services and to configure business processes as a sequence of services. Furthermore, the required software components must be available packaged as application-independent web services. So, even if a company applies SOA, important remaining challenges include the development of: i) generic information models that specify families of business processes and services, ii) tools that support configuration of specific business process and service architectures, iii) repository of software components software that are packaged as application-independent web services (Verdouw et al., 2010b, Wolfert et al., 2010).
In sum, it can be concluded that enterprise software (ERP), configurators and Service-oriented Architecture (SOA) together could meet the requirements of ICT mass customisation (see Table 1). ERP can ensure the availability of the software modules in a repository of building blocks that form the heart of mass customizable information systems. However, the development towards modularized and service-oriented ERP is a crucial prerequisite to achieve this. Furthermore, configurators can provide the configuration support as required in mass-customisable information systems. It helps to elicit the required functionality of specific instantiations of information systems building upon a generic information model. Last, Service-Oriented Architecture (SOA) can help to meet, in particular, the requirements concerning software modularity and it provides an information integration platform.
Requirements ICT mass customization (Verdouw et al. 2010b) | Enterprise software (ERP) | Configurators | Service-oriented Architecture (SOA) |
a. Generic information models | X | ||
b. Modular software | X | ||
c. Information integration platform | X | ||
d. Configuration support | X | ||
e. Component availability | X |
Main contributions of ERP, configurators and SOA to the requirements of ICT mass customization
The next section discusses some strategies on how the strengths of ERP, configurators and SOA can be combined to enable mass customisation of information systems.
Following Verdouw et al. (2010a), three basic strategies can be distinguished to implement ICT mass customization by combining the strengths of ERP, configurators and SOA. Each includes a different division of product configuration, process configuration and management of the order fulfilment among dedicated configurator software, ERP systems and service-oriented middleware.
In the first strategy, process models are defined, configured and executed in a SOA-based process management platform, which intermediates between front- and back office systems, in particular product configurators and ERP systems for planning and scheduling.At this option, the functionality for product and process configuration is provided by different applications. Process configuration is done outside product configurators in service-oriented middleware.
Implementation of such an approach is complex. To mention some difficulties: the constraints arising from the actual availability of the required resources should be taken into account, as well as the dependences between configuration choices; it must be possible to inherit configuration choices from the product requirement definition to detailed process diagrams; and configuration choices must be translated into graphical diagrams. SOA-based process management platforms do not yet provide tool support for the configuration of process models in a manageable and user-friendly way.
Another important challenge of the first strategy is to find solutions for some technical problems that will arise when implementing process configuration in a SOA-based platform. For example, solutions have to be found to solve the problems arising from the redundancy of process knowledge as the defined in the process models of SOA-platforms and the hard-coded process logic in legacy systems. Furthermore, the incorporation of process model configuration into the run-time system will impact systems performance, in particular if the reference models are used by multiple organisations. In the latter case, also security will be an issue.
The second strategy is the inclusion of process configuration in dedicated configurator software.For this option, both product and process configuration are incorporated within one configurator and this tool is integrated with external planning & scheduling systems, either directly or via service-oriented middleware. The main challenge of this option is to manage the intensive interactions between the configurator and with external planning & scheduling systems, in particular in case of frequent reconfiguration of the workflow due to unexpected events. The most natural solution direction is to integrate both types of systems via service-oriented middleware. The implementation issues are similar to the first discussed implementation, except that the tool support for process configuration is not included in the SOA-based platform but in an external tool. Consequently, additional challenges include how to translate the output of the process configurator into a process model notation that can be interpreted by the SOA-based platform.
The third and last strategy is to include both product and process configuration into the ERP system and thus integrate all features (product configuration, process configuration and planning and scheduling) within one system. In this case, the ERP system is also the front office for customer interaction.There is no need for defining process models in SOA standards like Business Process Modelling Notation (BPMN) and some of the technical problems mentioned above can be solved easier. For example, the redundancy of process logic could be solved by using process models as the basis for system parameterisation. Furthermore, most ERP systems include functionality for product model definition and product configuration. This makes it easier to use process models for linking product configuration to the execution in back office systems. However, to do so, ERP systems should contain functionality for process modelling and the process models should be the basis for system usage. Many available ERP systems do not include such functionality. More importantly, ERP systems are not based on a modular approach, which is a fundamental precondition for the usage of process models to guide the workflow planning and execution in run-time information systems. At the same time, for many companies it is no realistic option to replace current systems with new flexible solutions is for many companies, among others because of the significant investments in legacy and the risks of losing stability. Because of these limitations, it might be preferably to keep the configuration of process models out of the ERP system.
The main objectives of this chapter were to define the requirements to information systems in agile supply chains and to develop strategies for implementation of agile information systems.
The chapter has first introduced a typology of supply chain strategies and the role of information systems in these strategies.The type of supply chain determines the required flexibility of front- and back-office systems. Efficient supply chains require stable, straight-forward planning systems for both front-office and back-office. Risk-hedging supply chains require the same type of stable front-office systems as efficient supply chains do. However, they require flexible back-office systems, integrated with production control systems and supplier’s systems. Responsive supply chains place high demands on the ability to combine fluctuations in demand and available supplies with respect to product specifications and lead times. Agile supply chains require flexibility in both front-office and back-office systems. They demand flexible ERP in the back-office and sophisticated configurator and customer communications systems in the front-office.
Next, the chapter has focused on information systems in the quadrant of agile supply chains. It is argued that these supply chains information systems should support an ICT mass customisation approach. ICT mass customisation combines the seemingly contradictory notions of efficient standard software and flexible customised software. It enables customer-specific assembly of information systems from a repository of standard components. Five requirements for the enhancement of ICT mass customisation have been defined:a) generic information model, b) modular software, c) information integration platform, d) configuration support, and e) component availability.
In the next section the role of ERP systems, configurators and SOA to enable ICT mass customisation is defined. None of these technologies completely satisfy the defined requirements, but together they could enable ICT mass customisation. ERP can ensure availability of the software modules in a repository of building blocks that form the heart of mass customizable information systems. However, the development towards modularized and service-oriented ERP is a crucial prerequisite to achieve this. Furthermore, configurators can provide the configuration support as required in mass-customisable information systems. It helps to elicit the required functionality of specific instantiations of information systems building upon a generic information model. Last, Service-Oriented Architecture (SOA) can help to meet, in particular, the requirements concerning software modularity and it provides an information integration platform.
The chapter concludes with the introduction of three basic strategies for the implementation of agile information systems. The strategies involve different divisions of product configuration, process configuration and management of the order fulfilment among ERP systems, dedicated configurator software and SOA platforms. All of the strategies entail order-specific configuration of the process model. The strategies differ in the technology to be used for that purpose and the location of the knowledge required for process configuration. The first strategy is to implement intelligent process configuration in the middleware that mediates between front-office systems (sales and product configurators) and back-office (ERP) systems. This approach would require a considerable advancement of the state-of-the-art in service composition. The second strategy is to include process configuration in the product configurator, thus enabling simultaneous configuration of product and process. This second approach would require the extension of current product configurators. Since process configuration depends on current and expected state of the back-office, it would also entail extensive and frequent information exchange between front-office and back-office systems. The third strategy is to implement order specific process configuration in the back-office ERP system. The latter strategy would avoid redundancy of process knowledge, but many current ERP systems do not support the modular process modelling approach and the dynamic configuration support required to realise this strategy. The first or the second strategy might be preferred depending on (among other factors) the extent of supply uncertainty in a particular branch of industry.
Endocrine-disrupting chemicals (EDCs) are exogenous substances or mixtures of chemicals that can disrupt male and female endocrine function through the interaction with hormone receptors. They lead to alterations in hormone action, synthesis, transport and metabolic processes [1]. Several compounds such as dioxins, plastic contaminants (e.g., bisphenols (BP)), triclosan (TCS), pesticides and herbicides (e.g., diphenyl-dichloro-trichloroethane (DDT)), metals and others are known EDCs [2].
Humans may be exposed to EDCs due to contamination of water and food chain, inhalation of contaminated house dust and through occupational exposure [2]. Although, in some westernized countries the use of certain EDCs has been banned, there are cases that human exposure to these chemicals is inevitable. Thus, during the past decades, human exposure to EDCs has received increased attention, and particular focus has been given to the harmful effects of EDCs to the male reproductive system. Evidences suggest that EDCs may have significant adverse effects on human health and are contributing to the trends in occurrence of male reproductive health problems and the decline in male fertility [3]. According to the literature, male reproductive decline may result from a combination of morphological, functional and molecular alterations in the reproductive organs, often due to exposure to EDCs. Most studies are focused either on the evaluation of basic seminal parameters or reproductive outcomes, but there are evidences that EDCs may impact at the level of the reproductive and endocrine systems. For example, there are evidences that TCS has a tendency to bioaccumulate in the epididymis [4]. Bisphenol A (BPA) has been reported to have both estrogenic and antiandrogenic effects [5, 6, 7]. It has been also negatively associated with sperm quality [8, 9, 10]. Toxicological studies showed that BPA caused adverse reproductive outcomes, namely, decreased epididymal weight, daily sperm production and testosterone (T) levels in rodents [11, 12, 13]. Recently, our group performed a systematic review regarding the effect of exposure to mercury (Hg) on human fertility [14]. Results revealed that higher levels of Hg in blood and hair were associated with male subfertility or infertility status.
This chapter summarizes the effects of male exposure to EDCs on markers of male fertility. The agents discussed here, which include TCS, BPA, metals (such as cadmium (Cd) and Hg), polychlorinated biphenyls (PCBs) and others were chosen based on their human exposure prevalence and adverse effects on human reproductive health.
The male reproductive system is composed by two testes, a system of genital ducts, the accessory glands (seminal vesicles, prostate, Cowper and Littre glands) and the penis [15]. Testes, the male sexual glands, are ovoid organs localized outside the abdominal cavity within the scrotum. This localization maintains the temperature at 2–4°C lower than the body temperature, optimal for the testes function. Testes are surrounded by two different layers of protective tissue, the
Schematic representation of the effects of EDCs on HPG axis and testicular morphology.
Evidences suggest that the normal morphology and function of the male reproductive system are affected by several factors including environmental pollutants (Figure 1) (e.g., EDCs). In addition to altered testicular morphology and dysfunction, exposure to EDCs also increased the incidence of testicular pathologies. For instance, exposure to phthalates was associated with the development of testicular cancer, cryptorchidism and hypospadias [17]. This section discusses the current knowledge on reproductive system EDC toxicity in humans and other animals.
The volume/weight of the male reproductive organs is an important indicator of the integrity of this system. Several animal studies showed a significant decrease in the weight of the testes and sex accessory tissues in animals exposed to EDCs [4, 18, 19, 20, 21, 22, 23]. For instance, male rats treated with 10 and 20 mg/(kg day) of TCS revealed a significant decrease in the weight of the testes, epididymis, ventral prostate, vas deferens and seminal vesicles [18]. However, an administration of 5 mg/(kg day) of TCS did not cause significant change in the testes and sex accessory tissues [18]. Recently, Lan et al. [4] showed that the absolute weights of testes and epididymis of rats treated with 10, 50 or 200 mg/kg of TCS were not significantly affected.
Rodents were exposed to BPA by the oral route or subcutaneous injections [24, 25]. A dose of 2 ng/g body weight induced a decrease in epididymal weight and an increase in prostate weight. Bisphenol S (BPS), considered a safe substitute for BPA, has chemical similarities with BPA and may act as an EDC. Thus, a recent work compared the effects of BPA and BPS on the morphology and physiology of the ventral prostate of adult gerbils [26]. Animals treated with BPA and BPS showed no alterations in prostate weight. Regarding histopathology, BPS-treated animals showed intense prostatic hyperplasia; increased relative frequency of epithelium, muscular stroma and non-muscular stroma; and decreased luminal compartment, and BPA-treated animals showed increased occurrence of hyperplastic growth. But, in general the authors found that BPS promoted more structural and histopathological changes than BPA.
Exposure to metals also induced effects on testes size. A dose of 5 mg/kg body weight of cadmium chloride (CdCl2) administered to rats by oral gavage caused a significant decrease in testes and epididymis weight [19]. Moreover, Hg and zinc (Zn) significantly decreased the absolute and relative testicular weights in murine, with Hg producing the highest reduction in weight [27]. Similar results were obtained by Narayana et al. [22] and Geng et al. [23] that showed a decrease in the weights of reproductive organs of rats exposed to pesticides.
Rats exposed to phthalates demonstrated reduced testicular weights and histologic changes in the seminiferous tubules [20, 21]. Moreover, rats exposed to phthalates during the prenatal period developed reproductive anomalies, namely, smaller testes and penis size [28].
Human studies related to the effects of exposure to EDCs on testicular volume/weight are limited but in accordance with animal studies. For instance, in a study in Croatian men, no occupational exposures were exposed to metals, and blood Cd was negatively correlated with testes size, suggesting that this metal exerts toxicity on human testes [29].
Experimental studies showed that exposure to EDCs had adverse effects on testes, resulting in testicular damage at structural and consequently functional level. Male rats treated with 20 mg/(kg day) of TCS exhibited several histopathological malformations in the testes and sex accessory tissues [18]. Lumen of vas deferens from the treated rats exhibited the presence of stereocilia detached from the epithelium and the presence of eosinophilic bodies. Moreover, the stereocilia were found to be thin, few or absent in the epithelium of TCS-treated rats. Rats treated with a high dose of TCS (200 mg/kg) showed changes in the cauda epididymis and in the testis compared with the control group [4]. In the cauda epididymis, the alterations included vacuolated and exfoliated epithelial cells. Moreover, these authors identified the absence of sperm tails in the seminiferous tubules in the TCS-treated groups.
Mice exposed to BPA showed the formation of morphologically multinucleated giant cells in testicular seminiferous tubules [30], disruption of the blood-testis barrier (BTB) and impaired spermatogenesis [31, 32]. Similar results were obtained by other study using pesticides that induced severe degenerative changes in seminiferous tubules [23]. Metals, such as Cd and Hg, also induced structural alterations in the testis structure, including damage in the vascular endothelium and in the BTB integrity and necrosis and disintegration of spermatocytes [27, 33]. In general, these animal studies showed that EDCs induced changes in testicular morphology, which may be a reason for the decline of male fertility. For instance, damage in epididymis compromise the transport of testicular sperm out of the testis, the acquisition of progressive spermatozoa motility and the sperm storage. Moreover, damage at SC and LC levels compromise the structure of the BTB and seminiferous tubules.
The two main functions of the testes are spermatogenesis (exocrine function) and steroidogenesis (endocrine function). In normal conditions the gonadotrophin-releasing hormone (GnRH) is secreted by the hypothalamus, stimulating the synthesis of LH and the follicle-stimulating hormone (FSH) [34]. LH is recognized by LH receptors in LC stimulating T biosynthesis (steroidogenesis). FSH is recognized by FSH receptors in SC having an important role in spermatozoa production (spermatogenesis). Several studies showed that these functions are affected by exposure to EDCs (Figure 1) [10, 18, 35, 36, 37, 38, 39]. Prenatal exposure to EDCs was associated with testicular anomalies later in life, which includes reduced semen volume and quality, increased incidence of cryptorchidism and hypospadias and increased incidence of testicular cancer [40]. EDCs reduced SC number and impaired LC development, inducing testicular anomalies at morphological and functional level [39]. This section presents the studies that assessed the relationship between animal and human exposure to EDCs and testicular dysfunction, including alterations in reproductive hormone levels.
Evidences from animal studies suggest that TCS reduces the production of T in LC and disturbs the function of major steroidogenic enzymes [41, 42]. Male rats treated with TCS or pesticides showed a significant decrease in the levels of serum LH, FSH, cholesterol, pregnenolone and T compared to control [18, 23]. Regarding human studies, a case-control study showed that urinary levels of phthalates and TCS were negatively associated with inhibin B and positively with LH [39]. Additionally, an inverse association was found between urinary levels of phthalates or BPA and testosterone and estradiol (E2) [38, 39]. Similar results were obtained by Meeker et al. [35] that showed an inverse association between BPA concentrations in urine and serum levels of inhibin B and E2:T ratio in men recruited through an infertility clinic. Moreover, a positive association between BPA concentrations in urine and FSH and FSH:inhibin B ratio was found. Hanoaka et al. [36] did not found an association between exposure to BPA and free T and LH concentrations in men. However, a significant decrease in FSH concentrations was found in the BPA exposed men. Urinary levels of BPA were not associated with sperm quality in fertile men but were associated with markers of androgenic action [37]. A significant inverse association was found between urinary levels of BPA and free androgen index (FAI) levels and the FAI:LH ratio. Further, a significant positive association between BPA and sex hormone-binding globulin (SHBG) was found in fertile men. Recently, Lassen et al. [10] examined associations between urinary BPA concentration and reproductive hormones in young men from the general population. The authors found positive associations between urinary BPA concentrations and T, E2, LH and free T levels. BPA and BPS induced significant changes in T and estradiol [26].
Meeker et al. [38] demonstrated that exposure to phthalates may be associated with altered male endocrine function. Urinary concentrations of some phthalates were inversely associated with T, E2 and FAI.
Metals, namely, Cd, also affect the development of the male reproductive system and testis function. Mice prenatal exposed to Cd showed defects on the development of gonads, depletion of germ cells and impairment of spermatozoa maturation [43]. Cd also induces testicular dysfunction, which results of the functional impairment of SC and LC. Regarding human studies, the effect of Cd exposure to male endocrine function was assessed by several authors (as reviewed by de Angelis et al. [33]). The results obtained are controversial; some authors found that Cd concentrations were positively correlated with FSH, T, E2, LH and inhibin B and negatively correlated with prolactin [29, 44]. However, other authors did not find significant correlations between Cd concentrations and serum hormone levels [45, 46]. In general, these results suggest that exposure to EDCs may be associated with alterations in circulating hormone levels in men. Additionally, Yang et al. [47] showed that levels of GnRH and LH were significantly higher in occupationally manganese (Mn)-exposed group compared with the non-exposed men. The levels of T were lower in the exposed group. However, this study demonstrated that there was no association between exposure to Mn and E2 and FSH and prolactin levels.
The effects of EDCs on the morphology and function of the male reproductive system may be attributed to the interactions of these chemicals with several molecules. Male rats treated with 20 mg/(kg day) of TCS showed a significant reduction in the testicular levels of mRNA for cholesterol side-chain cleavage enzyme (
In vitro studies investigated the effect of BPA on steroidogenesis [48, 49]. The authors found that BPA inhibited the production of testosterone in a concentration-dependent manner over the course of the 24 h incubation [48]. Moreover, the concentrations of E2 were greater in the presence of BPA. The decrease in the concentrations of T is related with the inhibition of activities of some enzymes, such as 3β-hydroxysteroid dehydrogenase (
The testes from male Sprague-Dawley rats treated with CdCl2 showed a significant increase in the activities of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) [19]. Geng et al. [23] found that pesticides altered the testicular protein expression of B-cell lymphoma 2 (Bcl-2) and Bcl-2-associated X protein (Bax). Moreover, these authors showed that the activities of testicular enzymes including acyl carrier protein (ACP), lactate dehydrogenase (LDH) and gamma-glutamyltransferase (γ-GT) were significantly altered by exposure to pesticides.
Sperm motility, together with concentration and morphology, is considered as one of the important predictors of male fertility in vivo. Declining human sperm quality has been demonstrated in several recent studies. Age, lifestyle, environmental pollutants and nutritional factors can affect semen quality [14, 50, 51, 52]. The present section focuses on studies of environmental exposure to EDCs and male reproductive function, as measured by declines in semen quality parameters or increased sperm DNA damage/fragmentation.
Several studies have been published regarding the association of exposure to phenols and human semen quality [53, 54, 55]. A case–control study was conducted to evaluate the association between exposure to phenols and idiopathic male infertility [55]. For that, the authors recruited idiopathic infertile men and fertile controls and measured urinary levels of BPA, benzophenone-3, pentachlorophenol, TCS, 4-
TCS has been shown to decrease sperm density probably due to reduced testicular spermatogenesis [18]. A reduced sperm density was observed in the lumina of epididymal tubule from the treated rats. Rats treated with high doses of TCS (50 and 200 mg/kg) showed a significant decrease in the daily sperm production and an increase in the percentage of sperm abnormalities, which included elevated ratios of abnormal sperm head and tails [4]. Zhu et al. [56] performed a cross-sectional study to evaluate the association between exposure to TCS measured by urinary TCS concentration and semen quality in humans. The authors found an association between urinary TCS concentrations and poor semen quality parameters; namely, the authors found an inverse association between urinary TCS concentrations and percentage of sperm motility, sperm count, sperm concentration and percentage of normal morphology, suggesting that environmental exposure to TCS may have impact on semen quality.
Regarding exposure to PCBs, several studies showed an inverse association between exposure to PCB 153 and sperm motility, while relationships with sperm concentration or total sperm count were inconsistent [57, 58, 59]. Additionally, Hauser et al. [60] found an inverse dose–response relationship between PCB 138 and sperm concentration, motility and morphology.
The correlation between exposure to metals and adverse consequences for human and animal fertility is not completely established. Several studies determined the effects of exposure to metals on male gametes. In vitro studies, using bovine sperm, determined the effect of direct exposure to Hg on male gametes [61, 62]. Arabi et al. [61] showed that exposure to Hg (50, 100, 200, and 300 μmol/l) induced LPO (lipid peroxidation), decreased the glutathione (GSH) content and decreased the percentage of viable spermatozoa. Additionally, a more recent study showed that bovine sperm exposed to Hg at 8 nM and 8 μM have less motility and have impaired sperm membrane integrity, increasing levels of reactive oxygen species (ROS) and LPO and decreasing the antioxidant activity and diminished fertility ability [62]. Regarding human fertility, in a cross-sectional study, participants with high blood Hg level had lower sperm with a normal morphology [63]. Cd is another male reproductive toxicant that exerts effects even at low levels of exposure by several mechanisms [64]. In vitro studies on human spermatozoa obtained through ejaculation allow to evaluate the effect of Cd treatment in semen parameters [65, 66]. Cd decreased sperm motility and sperm viability and induced detrimental effects on spermatozoa metabolism by inhibition of the activity of glycogen phosphorylase, glucose-6-phosphatase, fructose-1,6-diphosphatase, glucose-6-phosphate isomerase, amylase, Mg2+−dependent ATPase and lactic and succinic acid dehydrogenases. As reviewed by de Angelis et al. [33], significant negative correlations were found between Cd levels and semen parameters, including total sperm count, concentration, motility and morphology. Results from a meta-analysis indicate that men with low fertility had higher semen Pb and Cd levels and lower semen Zn levels [67]. Sperm motility was significantly decreased in men occupationally exposed to Mn [47].
Occupational exposure to pesticides increased the risk of morphological abnormalities in sperm in addition with a decline in sperm count and a decreased percentage of viable spermatozoa. For instance, the exposure to pesticides reduced the seminal volume, sperm motility and concentration and increased the seminal pH and the abnormal sperm head morphology [68, 69, 70]. A study showed that young Swedish men exposed to phthalates presented a decrease in progressive sperm motility [71]. Additionally, levels of urinary phthalates and insecticides were also associated with lower sperm concentration, lower motility and increased percentage of sperm with abnormal morphology [72, 73, 74, 75]. These results confirmed the results obtained by in vitro and in vivo studies [76, 77].
Sperm DNA integrity is essential for the correct transmission of genetic information [78]. Damage at sperm DNA level may result in male infertility. Sperm DNA damage is caused by oxidative stress that causes impairment in the sperm membrane [79]. It is well-known that some EDCs may induce oxidative stress and decrease the cellular levels of GSH and protein-sulfhydryl groups. Preclinical studies with male rats showed that exposure to BPA was associated with a significant increase in sperm DNA damage [80]. A statistically significant positive association between urinary concentrations of parabens and BPA and sperm DNA damage was found in male partners of subfertile couples [53, 81]. Contrary results were obtained by Goldstone et al. [8] that found a negative relationship between BPA and DNA fragmentations.
Additionally, other EDCs such as heavy metals (e.g., Hg), PCBs and insecticides induce sperm DNA damage [59, 61, 73, 75, 82, 83, 84]. Urinary levels of Hg and nickel in infertile men were associated with increasing trends for tail length, and the levels of Mn were associated with increasing trend for tail distributed moment [82]. The adverse effects of phthalates on sperm DNA were assessed by several studies among infertile men [75, 84]. Urinary concentrations of phthalate metabolites were associated with sperm DNA damage. These studies suggest that environmental and occupational exposure to EDCs may be associated with increased sperm DNA damage.
The results yielded in this chapter showed that both environmental and occupational exposures to EDCs affect male reproductive function at multiple levels. In human populations, the majority of studies point toward an association between exposure to EDCs and male reproduction system disorders, such as infertility, testicular cancer, poor sperm quality and/or function. Exposure to EDCs was associated with declined semen quality, increased sperm DNA damage, alterations in testis morphology and endocrine function. However, there are studies exploring the effect of EDCs on male reproductive health including semen quality, reproductive hormones and male fertility that produced inconsistent results probably due to small-sized study populations and lack of control for potential confounding variables. These contrary results highlight the need to discuss and investigate the effect of environmental pollutants in the male reproductive health. Moreover, the identification of the sequence of events and mechanisms might be important to better understand the effect of exposure to EDCs on male reproductive system and their contribution to male fertility decline.
Thanks are due to the support of iBiMED (UID/BIM/04501/2013, UID/BIM/04501/2019 and POCI-01-0145-FEDER-007628), CESAM (UID/ AMB/50017/2019 and POCI-01-0145-FEDER-007638) and FCT/MEC through national funds. We are also thankful to FCT of the Portuguese Ministry of Science and Higher Education by an individual grant to M.C.H. (SFRH/BD/131846/2017).
The authors declare no conflicts of interest.
ACP | acyl carrier protein |
ALT | alanine aminotransferase |
AR | androgen receptor |
AST | aspartate aminotransferase |
Bax | Bcl-2-associated X protein |
Bcl-2 | B-cell lymphoma 2 |
BP | bisphenols |
BPA | bisphenol A |
BPS | bisphenol S |
BTB | blood-testis barrier |
Cd | cadmium |
CdCl2 | cadmium chloride |
DDT | diphenyl-dichloro-trichloroethane |
E2 | estradiol |
EDCs | endocrine-disrupting chemicals |
FAI | free androgen index |
FSH | follicle-stimulating hormone |
GnRH | gonadotropin-releasing hormone |
GSH | glutathione |
Hg | mercury |
LC | Leydig cells |
LDH | lactate dehydrogenase |
LH | luteinizing hormone |
Mn | manganese |
PCBs | polychlorinated biphenyls |
ROS | reactive oxygen species |
SC | Sertoli cells |
SHBG | sex hormone-binding globulin |
StAR | steroidogenic acute regulatory protein |
T | testosterone |
TCS | triclosan |
Zn | zinc |
γ-GT | gamma-glutamyltransferase |
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Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. 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Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. 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Her research interests include archaea metabolism, enzymes purification and characterization, gene regulation, carotenoids and bioplastics production, antioxidant\ncompounds, waste water treatments, and brines bioremediation.\nRosa María’s other roles include editorial board member for several journals related\nto biochemistry, reviewer for more than 60 journals (biochemistry, molecular biology, biotechnology, chemistry and microbiology) and president of several organizing committees in international meetings related to the N-cycle or respiratory processes.",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"15",title:"Chemical Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",isOpenForSubmission:!0,editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",slug:"sukru-beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",biography:"Dr. Şükrü Beydemir obtained a BSc in Chemistry in 1995 from Yüzüncü Yıl University, MSc in Biochemistry in 1998, and PhD in Biochemistry in 2002 from Atatürk University, Turkey. He performed post-doctoral studies at Max-Planck Institute, Germany, and University of Florence, Italy in addition to making several scientific visits abroad. He currently works as a Full Professor of Biochemistry in the Faculty of Pharmacy, Anadolu University, Turkey. Dr. Beydemir has published over a hundred scientific papers spanning protein biochemistry, enzymology and medicinal chemistry, reviews, book chapters and presented several conferences to scientists worldwide. He has received numerous publication awards from various international scientific councils. He serves in the Editorial Board of several international journals. 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He is a member of the Turkish Biochemical Society, American Chemical Society, and German Genetics society. Dr. Ekinci published around ninety scientific papers, reviews and book chapters, and presented several conferences to scientists. He has received numerous publication awards from several scientific councils. 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He worked on the structure-function relationships of glycoconjugates and his main project was the investigations on the biological roles of the de-N-glycosylation enzymes (Endo-N-acetyl-β-D-glucosaminidase and peptide-N4-(N-acetyl-β-glucosaminyl) asparagine amidase). From 2002 he contributes to the understanding of the Blood-brain barrier functioning using proteomics approaches. He has published more than 70 papers. 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Since then, he has been working as an Adjunct Professor in the same Department at the University of Pavia. His research activity during the first years was primarily focused on the purification and structural characterization of enzymes from animal and plant sources. During this period, Prof. Iadarola familiarized himself with the conventional techniques used in column chromatography, spectrophotometry, manual Edman degradation, and electrophoresis). Since 1995, he has been working on: i) the determination in biological fluids (serum, urine, bronchoalveolar lavage, sputum) of proteolytic activities involved in the degradation processes of connective tissue matrix, and ii) on the identification of biological markers of lung diseases. 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He also obtained an MSc in Molecular and Genetic Medicine, and a Ph.D. in Clinical Immunology and Human Genetics from the University of Sheffield, UK. He also completed a short-term fellowship in Pediatric Clinical Immunology and Bone Marrow Transplantation at Newcastle General Hospital, England. Dr. Rezaei is a Full Professor of Immunology and Vice Dean of International Affairs and Research, at the School of Medicine, Tehran University of Medical Sciences, and the co-founder and head of the Research Center for Immunodeficiencies. He is also the founding president of the Universal Scientific Education and Research Network (USERN). Dr. Rezaei has directed more than 100 research projects and has designed and participated in several international collaborative projects. He is an editor, editorial assistant, or editorial board member of more than forty international journals. He has edited more than 50 international books, presented more than 500 lectures/posters in congresses/meetings, and published more than 1,100 scientific papers in international journals.",institutionString:"Tehran University of Medical Sciences",institution:{name:"Tehran University of Medical Sciences",country:{name:"Iran"}}},{id:"180733",title:"Dr.",name:"Jean",middleName:null,surname:"Engohang-Ndong",slug:"jean-engohang-ndong",fullName:"Jean Engohang-Ndong",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180733/images/system/180733.png",biography:"Dr. Jean Engohang-Ndong was born and raised in Gabon. After obtaining his Associate Degree of Science at the University of Science and Technology of Masuku, Gabon, he continued his education in France where he obtained his BS, MS, and Ph.D. in Medical Microbiology. He worked as a post-doctoral fellow at the Public Health Research Institute (PHRI), Newark, NJ for four years before accepting a three-year faculty position at Brigham Young University-Hawaii. Dr. Engohang-Ndong is a tenured faculty member with the academic rank of Full Professor at Kent State University, Ohio, where he teaches a wide range of biological science courses and pursues his research in medical and environmental microbiology. Recently, he expanded his research interest to epidemiology and biostatistics of chronic diseases in Gabon.",institutionString:"Kent State University",institution:{name:"Kent State University",country:{name:"United States of America"}}},{id:"188773",title:"Prof.",name:"Emmanuel",middleName:null,surname:"Drouet",slug:"emmanuel-drouet",fullName:"Emmanuel Drouet",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/188773/images/system/188773.png",biography:"Emmanuel Drouet, PharmD, is a Professor of Virology at the Faculty of Pharmacy, the University Grenoble-Alpes, France. As a head scientist at the Institute of Structural Biology in Grenoble, Dr. Drouet’s research investigates persisting viruses in humans (RNA and DNA viruses) and the balance with our host immune system. He focuses on these viruses’ effects on humans (both their impact on pathology and their symbiotic relationships in humans). He has an excellent track record in the herpesvirus field, and his group is engaged in clinical research in the field of Epstein-Barr virus diseases. He is the editor of the online Encyclopedia of Environment and he coordinates the Universal Health Coverage education program for the BioHealth Computing Schools of the European Institute of Science.",institutionString:null,institution:{name:"Grenoble Alpes University",country:{name:"France"}}},{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",biography:"Dr. Rodriguez-Morales is an expert in tropical and emerging diseases, particularly zoonotic and vector-borne diseases (especially arboviral diseases). He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},{id:"332819",title:"Dr.",name:"Chukwudi Michael",middleName:"Michael",surname:"Egbuche",slug:"chukwudi-michael-egbuche",fullName:"Chukwudi Michael Egbuche",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/332819/images/14624_n.jpg",biography:"I an Dr. Chukwudi Michael Egbuche. I am a Senior Lecturer in the Department of Parasitology and Entomology, Nnamdi Azikiwe University, Awka.",institutionString:null,institution:{name:"Nnamdi Azikiwe University",country:{name:"Nigeria"}}},{id:"284232",title:"Mr.",name:"Nikunj",middleName:"U",surname:"Tandel",slug:"nikunj-tandel",fullName:"Nikunj Tandel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/284232/images/8275_n.jpg",biography:'Mr. Nikunj Tandel has completed his Master\'s degree in Biotechnology from VIT University, India in the year of 2012. He is having 8 years of research experience especially in the field of malaria epidemiology, immunology, and nanoparticle-based drug delivery system against the infectious diseases, autoimmune disorders and cancer. He has worked for the NIH funded-International Center of Excellence in Malaria Research project "Center for the study of complex malaria in India (CSCMi)" in collaboration with New York University. The preliminary objectives of the study are to understand and develop the evidence-based tools and interventions for the control and prevention of malaria in different sites of the INDIA. Alongside, with the help of next-generation genomics study, the team has studied the antimalarial drug resistance in India. Further, he has extended his research in the development of Humanized mice for the study of liver-stage malaria and identification of molecular marker(s) for the Artemisinin resistance. At present, his research focuses on understanding the role of B cells in the activation of CD8+ T cells in malaria. Received the CSIR-SRF (Senior Research Fellow) award-2018, FIMSA (Federation of Immunological Societies of Asia-Oceania) Travel Bursary award to attend the IUIS-IIS-FIMSA Immunology course-2019',institutionString:"Nirma University",institution:{name:"Nirma University",country:{name:"India"}}},{id:"334383",title:"Ph.D.",name:"Simone",middleName:"Ulrich",surname:"Ulrich Picoli",slug:"simone-ulrich-picoli",fullName:"Simone Ulrich Picoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334383/images/15919_n.jpg",biography:"Graduated in Pharmacy from Universidade Luterana do Brasil (1999), Master in Agricultural and Environmental Microbiology from Federal University of Rio Grande do Sul (2002), Specialization in Clinical Microbiology from Universidade de São Paulo, USP (2007) and PhD in Sciences in Gastroenterology and Hepatology (2012). She is currently an Adjunct Professor at Feevale University in Medicine and Biomedicine courses and a permanent professor of the Academic Master\\'s Degree in Virology. She has experience in the field of Microbiology, with an emphasis on Bacteriology, working mainly on the following topics: bacteriophages, bacterial resistance, clinical microbiology and food microbiology.",institutionString:null,institution:{name:"Universidade Feevale",country:{name:"Brazil"}}},{id:"229220",title:"Dr.",name:"Amjad",middleName:"Islam",surname:"Aqib",slug:"amjad-aqib",fullName:"Amjad Aqib",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229220/images/system/229220.png",biography:"Dr. Amjad Islam Aqib obtained a DVM and MSc (Hons) from University of Agriculture Faisalabad (UAF), Pakistan, and a PhD from the University of Veterinary and Animal Sciences Lahore, Pakistan. Dr. Aqib joined the Department of Clinical Medicine and Surgery at UAF for one year as an assistant professor where he developed a research laboratory designated for pathogenic bacteria. Since 2018, he has been Assistant Professor/Officer in-charge, Department of Medicine, Manager Research Operations and Development-ORIC, and President One Health Club at Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan. He has nearly 100 publications to his credit. His research interests include epidemiological patterns and molecular analysis of antimicrobial resistance and modulation and vaccine development against animal pathogens of public health concern.",institutionString:"Cholistan University of Veterinary and Animal Sciences",institution:null},{id:"62900",title:"Prof.",name:"Fethi",middleName:null,surname:"Derbel",slug:"fethi-derbel",fullName:"Fethi Derbel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/62900/images/system/62900.jpeg",biography:"Professor Fethi Derbel was born in 1960 in Tunisia. He received his medical degree from the Sousse Faculty of Medicine at Sousse, University of Sousse, Tunisia. He completed his surgical residency in General Surgery at the University Hospital Farhat Hached of Sousse and was a member of the Unit of Liver Transplantation in the University of Rennes, France. He then worked in the Department of Surgery at the Sahloul University Hospital in Sousse. Professor Derbel is presently working at the Clinique les Oliviers, Sousse, Tunisia. His hospital activities are mostly concerned with laparoscopic, colorectal, pancreatic, hepatobiliary, and gastric surgery. He is also very interested in hernia surgery and performs ventral hernia repairs and inguinal hernia repairs. He has been a member of the GREPA and Tunisian Hernia Society (THS). During his residency, he managed patients suffering from diabetic foot, and he was very interested in this pathology. For this reason, he decided to coordinate a book project dealing with the diabetic foot. Professor Derbel has published many articles in journals and collaborates intensively with IntechOpen Access Publisher as an editor.",institutionString:"Clinique les Oliviers",institution:null},{id:"300144",title:"Dr.",name:"Meriem",middleName:null,surname:"Braiki",slug:"meriem-braiki",fullName:"Meriem Braiki",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/300144/images/system/300144.jpg",biography:"Dr. Meriem Braiki is a specialist in pediatric surgeon from Tunisia. She was born in 1985. She received her medical degree from the University of Medicine at Sousse, Tunisia. She achieved her surgical residency training periods in Pediatric Surgery departments at University Hospitals in Monastir, Tunis and France.\r\nShe is currently working at the Pediatric surgery department, Sidi Bouzid Hospital, Tunisia. Her hospital activities are mostly concerned with laparoscopic, parietal, urological and digestive surgery. She has published several articles in diffrent journals.",institutionString:"Sidi Bouzid Regional Hospital",institution:null},{id:"229481",title:"Dr.",name:"Erika M.",middleName:"Martins",surname:"de Carvalho",slug:"erika-m.-de-carvalho",fullName:"Erika M. de Carvalho",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229481/images/6397_n.jpg",biography:null,institutionString:null,institution:{name:"Oswaldo Cruz Foundation",country:{name:"Brazil"}}},{id:"186537",title:"Prof.",name:"Tonay",middleName:null,surname:"Inceboz",slug:"tonay-inceboz",fullName:"Tonay Inceboz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/186537/images/system/186537.jfif",biography:"I was graduated from Ege University of Medical Faculty (Turkey) in 1988 and completed his Med. PhD degree in Medical Parasitology at the same university. I became an Associate Professor in 2008 and Professor in 2014. I am currently working as a Professor at the Department of Medical Parasitology at Dokuz Eylul University, Izmir, Turkey.\n\nI have given many lectures, presentations in different academic meetings. I have more than 60 articles in peer-reviewed journals, 18 book chapters, 1 book editorship.\n\nMy research interests are Echinococcus granulosus, Echinococcus multilocularis (diagnosis, life cycle, in vitro and in vivo cultivation), and Trichomonas vaginalis (diagnosis, PCR, and in vitro cultivation).",institutionString:"Dokuz Eylül University",institution:{name:"Dokuz Eylül University",country:{name:"Turkey"}}},{id:"71812",title:"Prof.",name:"Hanem Fathy",middleName:"Fathy",surname:"Khater",slug:"hanem-fathy-khater",fullName:"Hanem Fathy Khater",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/71812/images/1167_n.jpg",biography:"Prof. Khater is a Professor of Parasitology at Benha University, Egypt. She studied for her doctoral degree, at the Department of Entomology, College of Agriculture, Food and Natural Resources, University of Missouri, Columbia, USA. She has completed her Ph.D. degrees in Parasitology in Egypt, from where she got the award for “the best scientific Ph.D. dissertation”. She worked at the School of Biological Sciences, Bristol, England, the UK in controlling insects of medical and veterinary importance as a grant from Newton Mosharafa, the British Council. Her research is focused on searching of pesticides against mosquitoes, house flies, lice, green bottle fly, camel nasal botfly, soft and hard ticks, mites, and the diamondback moth as well as control of several parasites using safe and natural materials to avoid drug resistances and environmental contamination.",institutionString:null,institution:{name:"Banha University",country:{name:"Egypt"}}},{id:"99780",title:"Prof.",name:"Omolade",middleName:"Olayinka",surname:"Okwa",slug:"omolade-okwa",fullName:"Omolade Okwa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/99780/images/system/99780.jpg",biography:"Omolade Olayinka Okwa is presently a Professor of Parasitology at Lagos State University, Nigeria. She has a PhD in Parasitology (1997), an MSc in Cellular Parasitology (1992), and a BSc (Hons) Zoology (1990) all from the University of Ibadan, Nigeria. She teaches parasitology at the undergraduate and postgraduate levels. She was a recipient of a Commonwealth fellowship supported by British Council tenable at the Centre for Entomology and Parasitology (CAEP), Keele University, United Kingdom between 2004 and 2005. She was awarded an Honorary Visiting Research Fellow at the same university from 2005 to 2007. \nShe has been an external examiner to the Department of Veterinary Microbiology and Parasitology, University of Ibadan, MSc programme between 2010 and 2012. She is a member of the Nigerian Society of Experimental Biology (NISEB), Parasitology and Public Health Society of Nigeria (PPSN), Science Association of Nigeria (SAN), Zoological Society of Nigeria (ZSN), and is Vice Chairperson of the Organisation of Women in Science (OWSG), LASU chapter. She served as Head of Department of Zoology and Environmental Biology, Lagos State University from 2007 to 2010 and 2014 to 2016. She is a reviewer for several local and international journals such as Unilag Journal of Science, Libyan Journal of Medicine, Journal of Medicine and Medical Sciences, and Annual Research and Review in Science. \nShe has authored 45 scientific research publications in local and international journals, 8 scientific reviews, 4 books, and 3 book chapters, which includes the books “Malaria Parasites” and “Malaria” which are IntechOpen access publications.",institutionString:"Lagos State University",institution:{name:"Lagos State University",country:{name:"Nigeria"}}},{id:"273100",title:"Dr.",name:"Vijay",middleName:null,surname:"Gayam",slug:"vijay-gayam",fullName:"Vijay Gayam",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/273100/images/system/273100.jpeg",biography:"Dr. Vijay Bhaskar Reddy Gayam is currently practicing as an internist at Interfaith Medical Center in Brooklyn, New York, USA. He is also a Clinical Assistant Professor at the SUNY Downstate University Hospital and Adjunct Professor of Medicine at the American University of Antigua. He is a holder of an M.B.B.S. degree bestowed to him by Osmania Medical College and received his M.D. at Interfaith Medical Center. His career goals thus far have heavily focused on direct patient care, medical education, and clinical research. He currently serves in two leadership capacities; Assistant Program Director of Medicine at Interfaith Medical Center and as a Councilor for the American\r\nFederation for Medical Research. As a true academician and researcher, he has more than 50 papers indexed in international peer-reviewed journals. He has also presented numerous papers in multiple national and international scientific conferences. His areas of research interest include general internal medicine, gastroenterology and hepatology. He serves as an editor, editorial board member and reviewer for multiple international journals. His research on Hepatitis C has been very successful and has led to multiple research awards, including the 'Equity in Prevention and Treatment Award” from the New York Department of Health Viral Hepatitis Symposium (2018) and the 'Presidential Poster Award” awarded to him by the American College of Gastroenterology (2018). He was also awarded 'Outstanding Clinician in General Medicine” by Venus International Foundation for his extensive research expertise and services, perform over and above the standard expected in the advancement of healthcare, patient safety and quality of care.",institutionString:"Interfaith Medical Center",institution:{name:"Interfaith Medical Center",country:{name:"United States of America"}}},{id:"93517",title:"Dr.",name:"Clement",middleName:"Adebajo",surname:"Meseko",slug:"clement-meseko",fullName:"Clement Meseko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/93517/images/system/93517.jpg",biography:"Dr. Clement Meseko obtained DVM and PhD degree in Veterinary Medicine and Virology respectively. He has worked for over 20 years in both private and public sectors including the academia, contributing to knowledge and control of infectious disease. 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