Specific questions involved in SMARTER goal setting framework as adapted from Hersh et al. [41].
\\n\\n
IntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\\n\\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
\\n\\nLaunching 2021
\\n\\nArtificial Intelligence, ISSN 2633-1403
\\n\\nVeterinary Medicine and Science, ISSN 2632-0517
\\n\\nBiochemistry, ISSN 2632-0983
\\n\\nBiomedical Engineering, ISSN 2631-5343
\\n\\nInfectious Diseases, ISSN 2631-6188
\\n\\nPhysiology (Coming Soon)
\\n\\nDentistry (Coming Soon)
\\n\\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\\n\\nNote: Edited in October 2021
\\n"}]',published:!0,mainMedia:{caption:"",originalUrl:"/media/original/132"}},components:[{type:"htmlEditorComponent",content:'With the desire to make book publishing more relevant for the digital age and offer innovative Open Access publishing options, we are thrilled to announce the launch of our new publishing format: IntechOpen Book Series.
\n\nDesigned to cover fast-moving research fields in rapidly expanding areas, our Book Series feature a Topic structure allowing us to present the most relevant sub-disciplines. Book Series are headed by Series Editors, and a team of Topic Editors supported by international Editorial Board members. Topics are always open for submissions, with an Annual Volume published each calendar year.
\n\nAfter a robust peer-review process, accepted works are published quickly, thanks to Online First, ensuring research is made available to the scientific community without delay.
\n\nOur innovative Book Series format brings you:
\n\nIntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\n\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
\n\nLaunching 2021
\n\nArtificial Intelligence, ISSN 2633-1403
\n\nVeterinary Medicine and Science, ISSN 2632-0517
\n\nBiochemistry, ISSN 2632-0983
\n\nBiomedical Engineering, ISSN 2631-5343
\n\nInfectious Diseases, ISSN 2631-6188
\n\nPhysiology (Coming Soon)
\n\nDentistry (Coming Soon)
\n\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\n\nNote: Edited in October 2021
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Their effective removal presents a challenge for water treatment technology. Biosorption of nutrients and pollutants has been used in sewage treatment since the discovery of the activated sludge process. It is a passive uptake process by which pollutants are adsorbed on the surface of cell walls and/or dissolved in structures of microorganism cells that are present in sludge. Sorbed pollutants remain in the sludge and can be potentially released back into the environment depending on their condition and the reversibility of the pollutant-sludge interaction. An overview of typical biosorption applications for the removal of nutrients, organic pollutants, and metals in wastewater treatment is provided in different areas of their use for the protection of aquatic ecosystems and human health. This book will be of interest to operators of wastewater treatment plants and sludge treatment and disposal facilities as well as to researchers and university students in the field of environmental engineering.",isbn:"978-1-78923-473-2",printIsbn:"978-1-78923-472-5",pdfIsbn:"978-1-83881-299-7",doi:"10.5772/intechopen.68261",price:119,priceEur:129,priceUsd:155,slug:"biosorption",numberOfPages:158,isOpenForSubmission:!1,isInWos:1,isInBkci:!1,hash:"3f1ce467c2d1349eb5b68d7aca025503",bookSignature:"Jan Derco and Branislav Vrana",publishedDate:"July 18th 2018",coverURL:"https://cdn.intechopen.com/books/images_new/6137.jpg",numberOfDownloads:16093,numberOfWosCitations:115,numberOfCrossrefCitations:115,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:218,numberOfDimensionsCitationsByBook:4,hasAltmetrics:1,numberOfTotalCitations:448,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"April 4th 2017",dateEndSecondStepPublish:"April 25th 2017",dateEndThirdStepPublish:"July 22nd 2017",dateEndFourthStepPublish:"October 20th 2017",dateEndFifthStepPublish:"December 19th 2017",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"80852",title:"Prof.",name:"Jan",middleName:null,surname:"Derco",slug:"jan-derco",fullName:"Jan Derco",profilePictureURL:"https://mts.intechopen.com/storage/users/80852/images/1215_n.jpg",biography:"Prof. Ján Derco, DSc. has graduated from the Faculty of Chemical and Food Technology, Slovak Technical University (SUT) as M.Sc. in Chemical Engineering. Then he started working at the Department of Environmental Engineering at the same faculty where he has continued his research. Later he obtained his PhD. and DSc. (doctor of sciences) graduations from the same University. Main field of his scientific interest are environmental engineering, biological wastewater treatment, modelling, design and optimisation, ozone based oxidation processes and priority substances and micropollutants degradation and transformation. Presently he is working as Professor at the Institute of Chemical and Environmental Engineering, SUT.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"5",totalChapterViews:"0",totalEditedBooks:"2",institution:{name:"Slovak University of Technology in Bratislava",institutionURL:null,country:{name:"Slovakia"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:{id:"206103",title:"Dr.",name:"Branislav",middleName:null,surname:"Vrana",slug:"branislav-vrana",fullName:"Branislav Vrana",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:null},coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"127",title:"Environmental Chemistry",slug:"environmental-sciences-environmental-chemistry"}],chapters:[{id:"61965",title:"Introductory Chapter: Biosorption",doi:"10.5772/intechopen.78961",slug:"introductory-chapter-biosorption",totalDownloads:1396,totalCrossrefCites:11,totalDimensionsCites:18,hasAltmetrics:0,abstract:null,signatures:"Ján Derco and Branislav Vrana",downloadPdfUrl:"/chapter/pdf-download/61965",previewPdfUrl:"/chapter/pdf-preview/61965",authors:[{id:"80852",title:"Prof.",name:"Jan",surname:"Derco",slug:"jan-derco",fullName:"Jan Derco"}],corrections:null},{id:"58112",title:"Biosorption of Heavy Metals",doi:"10.5772/intechopen.72099",slug:"biosorption-of-heavy-metals",totalDownloads:4854,totalCrossrefCites:26,totalDimensionsCites:51,hasAltmetrics:1,abstract:"Industrialization has led to introduction of heavy metals in the environment. Heavy metals are known to persist in the environment and become a risk for organisms. Micro-organisms are present in industrial effluents. They have adopted different strategies to cope up with the harmful effects of these metals. These strategies can be metabolism dependent or independent. One such strategy is biosorption which is binding of metal ions with metal binding proteins present on the cell wall. Biosorption is exhibited by bacteria, algae, fungi and yeasts. Not only living organisms, but also residuals of dead bodies of microorganisms shows biosorbent properties like agricultural wastes including husk, seeds, peels and stalks of different crops. Different factors affect the rate of biosorption which includes temperature, pH, nature of biosorbents, surface area to volume ratio, concentration of biomass, initial metal ion concentration and metal affinity to biosorbent. Various models including Freundlich model and Langmuir model can be used to describe biosorption. Recovery of biosorbed metals can be done using agents like thiosulfate, mineral acids and organic acids. Choice of desorption agent should be carefully selected to prevent alteration of physical properties of a biosorbent.",signatures:"Saba Shamim",downloadPdfUrl:"/chapter/pdf-download/58112",previewPdfUrl:"/chapter/pdf-preview/58112",authors:[{id:"209771",title:"Dr.",name:"Saba",surname:"Shamim",slug:"saba-shamim",fullName:"Saba Shamim"}],corrections:null},{id:"57841",title:"Biosorption of Multicomponent Solutions: A State of the Art of the Understudy Case",doi:"10.5772/intechopen.72179",slug:"biosorption-of-multicomponent-solutions-a-state-of-the-art-of-the-understudy-case",totalDownloads:1048,totalCrossrefCites:2,totalDimensionsCites:2,hasAltmetrics:1,abstract:"Although there has been an intense study and exploitation of research regarding biosorption processes, the lack of coherent and similar methodologies, essential to the elaboration of any consequential and universal conclusion, associated with the lack of biosorption studies conducted at a pilot and industrial scale, with multicomponent solutions or real effluents, as well as the lack of information regarding the pollutant interactions makes the implementation and commercialization of biosorption technology very complicated. This chapter summarizes the existing knowledge and the experimental work conducted at a pilot scale or industrial scale with multicomponent solutions and critically reviews aspects related to biosorption research regarding the advantages, the disadvantages, the rationale, the scope and scientific value of biosorption processes and the obstacles to commercial success.",signatures:"Filomena Costa and Teresa Tavares",downloadPdfUrl:"/chapter/pdf-download/57841",previewPdfUrl:"/chapter/pdf-preview/57841",authors:[{id:"216996",title:"Ph.D.",name:"Filomena",surname:"Costa",slug:"filomena-costa",fullName:"Filomena Costa"},{id:"220680",title:"Prof.",name:"Teresa",surname:"Tavares",slug:"teresa-tavares",fullName:"Teresa Tavares"}],corrections:null},{id:"62247",title:"Application of Biosorption for Removal of Heavy Metals from Wastewater",doi:"10.5772/intechopen.77315",slug:"application-of-biosorption-for-removal-of-heavy-metals-from-wastewater",totalDownloads:7494,totalCrossrefCites:69,totalDimensionsCites:133,hasAltmetrics:1,abstract:"Fresh water accounts for 3% of water resources on the Earth. Human and industrial activities produce and discharge wastes containing heavy metals into the water resources making them unavailable and threatening human health and the ecosystem. Conventional methods for the removal of metal ions such as chemical precipitation and membrane filtration are extremely expensive when treating large amounts of water, inefficient at low concentrations of metal (incomplete metal removal) and generate large quantities of sludge and other toxic products that require careful disposal. Biosorption and bioaccumulation are ecofriendly alternatives. These alternative methods have advantages over conventional methods. Abundant natural materials like microbial biomass, agro-wastes, and industrial byproducts have been suggested as potential biosorbents for heavy metal removal due to the presence of metal-binding functional groups. Biosorption is influenced by various process parameters such as pH, temperature, initial concentration of the metal ions, biosorbent dose, and speed of agitation. Also, the biomass can be modified by physical and chemical treatment before use. The process can be made economical by regenerating and reusing the biosorbent after removing the heavy metals. Various bioreactors can be used in biosorption for the removal of metal ions from large volumes of water or effluents. The recent developments and the future scope for biosorption as a wastewater treatment option are discussed.",signatures:"Sri Lakshmi Ramya Krishna Kanamarlapudi, Vinay Kumar\nChintalpudi and Sudhamani Muddada",downloadPdfUrl:"/chapter/pdf-download/62247",previewPdfUrl:"/chapter/pdf-preview/62247",authors:[{id:"238433",title:"Associate Prof.",name:"Sudhamani",surname:"Muddada",slug:"sudhamani-muddada",fullName:"Sudhamani Muddada"},{id:"244937",title:"Mrs.",name:"S L Ramyakrishna",surname:"Kanamarlapudi",slug:"s-l-ramyakrishna-kanamarlapudi",fullName:"S L Ramyakrishna Kanamarlapudi"},{id:"244938",title:"Mr.",name:"Vinay Kumar",surname:"Chintalpudi",slug:"vinay-kumar-chintalpudi",fullName:"Vinay Kumar Chintalpudi"}],corrections:null},{id:"57813",title:"Microbial-Based Bioremediation of Selenium and Tellurium Compounds",doi:"10.5772/intechopen.72096",slug:"microbial-based-bioremediation-of-selenium-and-tellurium-compounds",totalDownloads:1307,totalCrossrefCites:7,totalDimensionsCites:14,hasAltmetrics:0,abstract:"The chalcogens selenium (Se) and tellurium (Te) are rare earth elements, which are mainly present in the environment as toxic oxyanions, due to the anthropogenic activities. Thus, the increased presence of these chalcogen-species in the environment and the contamination of wastewaters nearby processing facilities led to the necessity in developing remediation strategies aimed to detoxify waters, soils and sediments. Among the different decontamination approaches, those based on the ability of microorganisms to bioaccumulate, biomethylate or bioconvert Se- and/or Te-oxyanions are considered the leading strategy for achieving a safe and eco-friendly bioremediation of polluted sites. Recently, several technologies based on the use of bacterial pure cultures, bacterial biofilms or microbial consortia grown in reactors with different configurations have been explored for Se- and Te-decontamination purposes. Further, the majority of microorganisms able to process chalcogen-oxyanions have been described to generate valuable Se- and/or Te-nanomaterials as end-products of their bioconversion, whose potential applications in biomedicine, optoelectronics and environmental engineering are still under investigation. Here, the occurrence, the use and the toxicity of Se- and Te-compounds will be briefly overviewed, while the microbial mechanisms of chalcogen-oxyanions bioprocessing, as well as the microbial-based strategies used for bioremediation approaches will be extensively described.",signatures:"Elena Piacenza, Alessandro Presentato, Emanuele Zonaro, Silvia\nLampis, Giovanni Vallini and Raymond J. 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The articles covered in the book would be experimental research papers, reviews, or minireviews addressing different synthesis methods of silver nanoparticles such as chemical, physical, biological/ green methods, microwave methods, and recent advancements in their characterization techniques. Another important aspect covered would be toxicity evaluation and the health impacts of silver nanoparticles. A broader insight would be provided on the applications of silver nanoparticles in wound healing, tissue engineering, drug delivery, cancer diagnosis, antimicrobial surfaces, corrosion protective coatings, regenerative medicine, therapeutic applications, and others. Biopolymer nanocomposites such as starch, chitosan, cellulose, and others reinforced with silver nanoparticles can also be included. The book would be targeting students, scientists, and researchers, from academia and industry interested in nanoscience and technology of biopolymers, biomedical and tissue engineering, and nanomedicine.
",isbn:"978-1-80356-744-0",printIsbn:"978-1-80356-743-3",pdfIsbn:"978-1-80356-745-7",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,hash:"eadac73f609da20167ba128e077b1669",bookSignature:"Dr. Eram Sharmin",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11463.jpg",keywords:"Silver Nanoparticles, Chemical Synthesis, Electrochemical Synthesis, Physical Synthesis, Nanocomposite Hydrogels, Silver Scaffolds, Ointments, Creams, Biopolymer Nanocomposites, Nanoparticles, Coatings, Bioactive",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"March 24th 2022",dateEndSecondStepPublish:"April 21st 2022",dateEndThirdStepPublish:"June 20th 2022",dateEndFourthStepPublish:"September 8th 2022",dateEndFifthStepPublish:"November 7th 2022",remainingDaysToSecondStep:"a month",secondStepPassed:!0,currentStepOfPublishingProcess:3,editedByType:null,kuFlag:!1,biosketch:'Dr. Eram Sharmin obtained her Ph.D. degree in Chemistry from Jamia Millia Islamia (JMI) - A Central University, India. She has more than 50 publications in peer-reviewed journals and books and has presented more than 30 research papers in national and international conferences. Her research interests include the development of "green” materials with applications such as antimicrobial and protective coatings, films, hydrogels, and packaging materials.',coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"107375",title:"Dr.",name:"Eram",middleName:null,surname:"Sharmin",slug:"eram-sharmin",fullName:"Eram Sharmin",profilePictureURL:"https://mts.intechopen.com/storage/users/107375/images/system/107375.jpeg",biography:'Dr. Eram Sharmin is an Associate Professor at the Department of Pharmaceutical Chemistry, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia. She obtained her Ph.D. degree in Chemistry from Jamia Millia Islamia (JMI) - A Central University, New Delhi, India, in the year 2007. She received her MSc degree in Organic Chemistry, in the year 2000, and BSc degree in Chemistry, in the year 1998, from Aligarh Muslim University (AMU), Aligarh, Uttar Pradesh (UP), India. She has previously worked as Senior Research Associate [Under Scientists’ Pool Scheme, Council of Scientific and Industrial Research (CSIR), New Delhi, India], Research Associate (CSIR, New Delhi), and Senior Research Fellow (CSIR, New Delhi), at Materials Research Laboratory, Department of Chemistry, JMI. She has more than 50 publications in peer-reviewed journals and books and has presented more than 30 research papers in national and international conferences. Her research interests include the development of "green” materials with applications as antimicrobial and protective coatings, films, hydrogels, and packaging materials.',institutionString:"Umm al-Qura University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"6",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"Umm al-Qura University",institutionURL:null,country:{name:"Saudi Arabia"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"17",title:"Nanotechnology and Nanomaterials",slug:"nanotechnology-and-nanomaterials"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"455410",firstName:"Dajana",lastName:"Jusic",middleName:null,title:"Mrs.",imageUrl:"https://mts.intechopen.com/storage/users/455410/images/20500_n.jpeg",email:"dajana.j@intechopen.com",biography:"As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review, to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact."}},relatedBooks:[{type:"book",id:"5857",title:"Spectroscopic Analyses",subtitle:"Developments and Applications",isOpenForSubmission:!1,hash:"1a73e911e2c6e2c94b6c039f602bc719",slug:"spectroscopic-analyses-developments-and-applications",bookSignature:"Eram Sharmin and Fahmina Zafar",coverURL:"https://cdn.intechopen.com/books/images_new/5857.jpg",editedByType:"Edited by",editors:[{id:"107375",title:"Dr.",name:"Eram",surname:"Sharmin",slug:"eram-sharmin",fullName:"Eram Sharmin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5884",title:"Unraveling the Safety Profile of Nanoscale Particles and Materials",subtitle:"From Biomedical to Environmental Applications",isOpenForSubmission:!1,hash:"5e5811aa0f15ab9d8b6a235e8408875d",slug:"unraveling-the-safety-profile-of-nanoscale-particles-and-materials-from-biomedical-to-environmental-applications",bookSignature:"Andreia C. 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Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"17226",title:"Near-Infrared Single-Photon Detection",doi:"10.5772/20323",slug:"near-infrared-single-photon-detection",body:'With the rapid increase of research interest in quantum information (Bennett&Brassard, 1984; Gisin et al., 2002; Knill et al., 2001), the near-infrared single-photon detection received a great boost not only in inventing (or improving) basic devices, but also in improving operation techniques on the conventional devices. Especially, in the application of quantum key distribution (Bennett&Brassard, 1984; Gisin et al., 2002), practical single-photon detectors (SPDs) with small size, operating at room-temperature are in great need.
Avalanche photodiodes (APDs) are usually used to build SPDs. Avalanche photodiodes (APDs) have internal gain due to a process of impact ionization that leads to multiple electron-hole pairs per input photon. Applying a large reverse voltage to the APD will result in a large multiplication gain, until the breakdown voltage (Vbr) is reached. Usually, the output photocurrent of the APDs is linearly proportional to the intensity of the optical input when the bias voltage is below Vbr, and this mode is called as “linear mode”. When the bias voltage is larger than Vbr, the electron-hole generation process can become self-sustaining and result in a runaway avalanche, then a single photoexicited carrier can induce a runaway avalanche that gives rise to a detectable macroscopic current, and this mode is called as “Geiger mode”. Si-APD SPD exhibits excellent performance with the spectral range from 400 to 1000 nm. Si APD is typically operated in free-running mode. Its detection efficiency is as high as 70% around 700 nm with the dark count rate (DCR) of 10-100 counts per second (Stipčević et al., 2010). InGaAs/InP APD has a spectrum response range from 1200 to 1700 nm, covering the fiber optical communication window at 1310 and 1550 nm. However, InGaAs/InP-APD SPD has a large dark count (e.g. DCR~105 per second) and afterpulsing effect. Especially, the serious afterpulsing effect of the InGaAs/InP APD limits the application of high-speed detection. In order to improve its performance, an InGaAs/InP APD is usually operated in gated Geiger mode to suppress dark counts and afterpulsing effect. Recently, (Yuan et al., 2007; Namekata et al., 2006) reported self-cancellation and sine-wave techniques, which exhibited great improvements on the InGaAs/InP-APD SPD. The single-photon detection speed was increased significantly from megahertz to gigahertz.
Previously, it was thought that APDs are unable to resolve the number of photons in a short time interval. (Kardynal et al., 2008) first found that by suppressing the capacitive response down to a sufficiently low level, the weak avalanche current of an InGaAs/InP APD can be discriminated in its early development before saturated. In this mode, the variation in multiplication gain of the current shows the capability of resolving photon number, called as “non-saturated” Geiger mode (Wu et al., 2009; Yuan et al., 2010). To date, some individual photon detectors have been demonstrated to exhibit interesting photon-number-resolving capability, such as visible light photon counters (Takeuchi et al., 1999), superconducting optical detectors (Miller et al., 2003; Schuster et al., 2007), and field effect transistors with quantum dots (Shields et al., 2000). All those developments have already stimulated vast promising applications although their performances are still limited by the requisite cryogenic operation.
On the other hand, several optical techniques have been developed to obtain high-performance near-infrared single-photon detection. A straightforward way to overcome the incapability of the current infrared detectors is to up-convert the infrared single photons with complete quantum state transfer into their replicas in the visual-near infrared region so that a Si-APD SPD can be used for the single-photon detection. Frequency up-conversion of 1550 nm single photons has been demonstrated by sum frequency mixing (Albota&Won, 2004; Pan et al., 2006). In particular, frequency up-converted single-photon detection facilitates a successful realization of a fiber-based QKD at gigahertz (Thew et al., 2006). Another optical technique for single-photon detection is just beginning (Han et al., 2008; Wu et al., 2010), where a high-gain optical amplifier is invented to amplify single photon to an intense light pulse. The spontaneous fluorescence is the major obstacle of the optical amplification technique to detect the single photon. (Han et al., 2008) used an optical parametric amplification, where the pulse width of the pump laser pulse was only 130 femtosecond. The influence of the spontaneous fluorescence was deeply suppressed in this ultra short period. (Wu et al., 2010) used a short optical bandpass filter to suppress the spontaneous fluorescence that few-photon pulse at 1550 nm could be detected.
In this chapter, we introduce some practical techniques of near-infrared single-photon detection, containing four sections as following: i) InGaAs/InP APD SPD; ii) Photon-number-resolving detector based on a InGaAs/InP APD; iii) Near-infrared single-photon detection with frequency up-conversion; iv) Few-photon detection with linear external optical gain photodetector.
The performance of an InGaAs/InP APD SPD is characterized by detection efficiency, dark count, afterpulsing effect, and time jitter, etc. The detection efficiency is mainly determined by two factors (Itzler et al., 2007): i) the quantum efficiency of the APD, which is the probability that a photon excited a carrier to reach the multiplication region, and ii) the avalanche breakdown probability, which figures the probability that a carrier in the multiplication region triggers an avalanche process successfully. The dark counts arise when carriers are created by processes other than photoexcitation, including the thermal excitation and field-mediated creation of free carriers (i.e. tunneling, trapping processes). Typically, the dark count rate of a Si-APD SPD is about 100 counts per second. However, the InGaAs/InP APDs have much more random bulk leakage carriers, leading to the dark count rate in the order of 105 counts per second. The afterpulsing effect is a dark count induced by the release of a carrier trapped by a defect in the multiplication region during an earlier avalanche event. In high-speed operation, the afterpulsing effect becomes the major problem that enhances dark counts. The time jitter is the variation in the temporal correspondence between the arrival of the photon and the detection of a resulting avalanche. It originates in the stochastic nature of the carrier dynamics involved with avalanche breakdown, typically in the order of 100 ps for Si-APD APD.
In order to decrease dark counts and afterpulsing effect, InGaAs/InP APDs are usually operated in gated Geiger mode, by applying a reverse bias above the breakdown voltage with a short gating pulse over a DC bias. However, strong capacitive response of the electric gating pulse will be produced by the junction capacitance of the APD, which buries the weak avalanche pulses when a short gating pulse is used. It is quite important to produce an electric signal equal to the capacitive response of the APD, before cancelling the capacitive response. Here we present three different noise-cancellation techniques to operate the InGaAs/InP APD in gated Geiger mode with the gating width ≤ 1ns.
An equal capacitance can make a similar electric signal when it is applied on a same gate pulse, as most of the capacitive response is induced by the junction capacitance of the InGaAs/InP APD. Figure 1 is the frequency responses of a InGaAs/InP APD and a variable capacitance, where the InGaAs/InP APD is tested with a DC bias of 50 V. It seems similar between the InGaAs/InP APD and the variable capacitance below 500 MHz. So, capacitance is a simple and economical method to produce a similar capacitive response in a large frequency range. As shown in Fig. 2, a same electric pulse is both applied on the fiber pigtailed InGaAs/InP APD and the variable capacitance. The responses of the InGaAs/InP APD and the variable capacitance are sent to two differential inputs of a differential amplifier, respectively. The common signal such as the capacitive response is deeply suppressed in the differential amplifier, while the avalanche pulse is amplified. There were also several other cancellation techniques which suppressed the capacitive response effectively (e.g. (Bethune&Risk, 2000) produced a capacitive response by a coaxial cable reflection line; (Tomita& Nakamura, 2002) used two APDs to produce two capacitive responses).
The InGaAs/InP APD is cooled to -35º C. The width of the electric gating pulse is 1 ns with the gating rate of 25 MHz. A distribution feedback (DFB) laser diode is triggered at 1 MHz with the pulse duration < 300 ps. The laser is synchronized at 1/25 of the electric gating pulse. And the laser pulses are attenuated to 0.1 photon per pulse before sent to the InGaAs/InP APD. The detection efficiency decreases with the bias voltage, seeing Fig. 3, and it becomes saturated at about 30%. However, the dark count and afterpulsing effect will degrade the detector when increase the bias voltage. As shown in Fig. 4, the dark count rate is less than 8×10-6 counts per gate at the detection efficiency of 10%. It exponential rises with the DC bias voltage until the detection efficiency of about 30%. Meanwhile, the afterpulsing effect is also measured with the detection efficiency. Figure 4 shows the afterpulsing probability at 40-ns delay after the first avalanche. It is less than 0.1% at the detection efficiency of 10%, and increases more slowly than the dark count rate below the detection efficiency of 25%. Then the afterpulsing effect dominates the dark count of the detector when the detection efficiency is close to 30%. The afterpulsing effect comes from the trapping effect in the multiplication region of the InGaAs/InP APD. The trapped carriers are exponential decay with time (Wu et al., 2006 ; Itzler et al., 2007). So the afterpulsing effect is the major obstacle for high speed operation, especially the adjacent two gating pulses should be less than 3 ns (Liang et al., 2011). Increasing the temperature of the InGaAs/InP APD can speed up the decay of the trapped carriers. However, it will obviously increase the dark count due to the thermal effect.
Frequency response of an APD and a variable capacitance, where dash line: the APD, solid line: the variable capacitance
Schematic of the balanced capacitance cancellation circuit, where Bias: DC bias + gating pulse, VC: a variable capacitance, DAMP: a differential amplifier, and AMP: a broadband amplifier
Detection efficiency as a function of DC bias voltage
Dark count rate and afterpulsing probability as a function of detection efficiency
Except rising the temperature, the other method to suppress the afterpulsing effect relies on decreasing the carriers passing through the APD, where shortening the gating width can decrease carriers. Figure 5 presents afterpulsing probability as a function of the gating width. It proves that short gating width is effective to suppress the afterpulsing effect for high speed operation.
Afterpulsing probability with the electric gating width
As mentioned above, shortening the gating width can decrease the number of bulk carriers passing through the InGaAs/InP APD, so it can weaken the afterpulsing effect for high speed operation. However, the avalanche current becomes weaker. It requires higher sensitivity, as well as better capacitive-response cancellation, to catch the avalanche pulse in the capacitive response. As shown in Fig. 1, the frequency responses between the InGaAs/InP APD and the variable capacitance are quite different when the frequency > 500 MHz. So, the variable capacitance cannot produce absolutely same capacitive response with the InGaAs/InP APD, although it has a same value of the capacitance. The self-cancellation technique solves the problem nicely. Figure 6 is the schematic of this technique. The electric signal on the cathode of the InGaAs/InP APD is sent to a 50/50 power splitter to produce two equal components. Then the two identical components are combined by a differencer, where one of the components is delayed by one gating period. The output of the differencer is the difference of the two components. Actually, they are the signals of two adjacent gating periods. The capacitive response is cancelled by itself. As a result, weak avalanche pulse can be discriminated at high-speed gating rate. (Yuan et al., 2010) promoted the gating rate as high as 2 GHz with the gating width of only 250 ps.
Schematic of the self-cancellation circuit
In self-cancellation technique, the electric signal transmits through two coaxial cables. Due to the large transmission loss of the coaxial cable, the delay of one component cannot be too long; resulting in the gating rate should be high (e.g. > 200 MHz). Moreover, the electric circuit of the self-cancellation has a very wide bandwidth > 2 GHz. It should take more attention on designing and manufacturing for high cancellation ratio of the capacitive response. The optical self-cancellation technique gives a simple method to realize self-cancellation in wide bandwidth, including the operation at low gating rate.
Figure 7 is the schematic of the optical self-cancellation. The InGaAs/InP APD response is magnified by a low-noise broadband amplifier to trigger a DFB laser diode at 1550 nm. The response bandwidth of the laser diode is 2.5 GHz, fast enough to transfer the electronic signal to light pulse while keeping the same shape. In this way, the AC electronic signal is transformed to optical signal, preserving the original information from the InGaAs/InP APD including the capacitive response and the avalanche pulse. The fiber connecting the splitter and the detectors has different lengths to introduce a delay of one gating period between the two components. A fiber stretcher is employed to precisely control the delay
Schematic of the optical self-cancellation circuit, where LD is a 1550-nm DFB laser diode, BS is a 50/50 fiber splitter, PD+ and PD- are the balanced optical detector
between the two components with 0.17-ps resolution. Two conventional photodiodes are used to detect the optical signals from each fiber. The response of the photodiodes exactly replayed the detection signal of the APD. At the output of the balancer, the identical capacitive response is subtracted. With this optical self-differential photodetector, the weak avalanche current can be measured (Wu et al., 2009).
It was thought that a single APD cannot resolve the incident photon number without time or space multiplexing techniques since the gain on the APD is saturated in Geiger mode. However, recent research result reveals that the avalanche current is proportional to the photon number of the input light pulse when the APD is operated in non-saturated Geiger mode. Figure 8 gives a typical avalanche trace. It is recorded by a 6-GHz digital oscilloscope with the gating width of 5 ns. The current grows gradually first within area (a), and then it becomes saturated in area (b). Area (a) is the non-saturated Geiger mode period that the current is proportional to the input photon number. However, the saturation inhibits all the variation in the early avalanche development in area (b). The avalanche is just beginning in area (a), which the current is much weaker than the current in area (b). Through the optical self-cancellation technique, the non-saturated avalanche pulse is observed successfully.
An avalanche trace in 5-ns electric gate
Figure 9 is a typical histogram of the output peaks of the avalanche pulses. The distribution of the peak output of the avalanche pulses shows 3 peaks. Obviously, these distribution peaks are induced by different input photon number. The input light is from a DFB laser. This coherent light source obeys the Poissonian distribution, where the photon number
where
where
Distribution of the peak output of the avalanche pulses, where the black line is the measured data, the red line is the calculated data. The detected mean photon number is 1.9 per pulse at the detection efficiency of 10%
Figure 10 is the color-grading waveforms of the avalanche pulses in non-saturated Geiger mode. It is recorded by a 6-GHz digital oscilloscope with the integration time of 0.1 second. Three peaks of the distribution of the avalanche pulses clearly appear in the waveforms. They are induced by 1-, 2-, and 3-photon, respectively.
Figure 8 shows that the non-saturated Geiger mode exits in a short period of the early avalanche development. As a result, in order to observe the capability of the photon-number-resolving (PNR) of the InGaAs/InP APD, the gating width should < 2 ns. In order to figure out the relation between the PNR performance and the avalanche multiplication, the distributions of the peak output of the avalanche pulses at different detection efficiency are measured as shown in Fig. 11. It is hard to resolve the photon number at low detection efficiency. And the optimal period of the detection efficiency for PNR is from 10% to 20%. When the detection efficiency increases to 36%, all the peak output of the avalanche pulses reach the maximum amplitude of 960 mV, the saturation effect appears obviously and the peak voltage is independent of the incident photon number more than 2. This sets the upper boundary for the InGaAs/InP APD to resolve photon numbers.
Color-grading waveforms of the avalanche pulses
Distribution of peak output of the avalanche pulses at different detection efficiencies
The PNR performance is time resolved with the input laser delay, since the non-saturated Geiger mode is observed in a short gated mode. Figure 12 shows the photon count rate varies with the laser pulse delay. The electric gating width is about 1.2 ns, while the effective detection gating width is about 300 ps. Three delays of the input laser are observed, they are signed as (a), (b), and (c) in Fig. 12. Figure 13 is the distribution of the peak output of the avalanche pulses at these three points. Obviously, the PNR performance is similar good at points (a) and (b). And the PNR performance degrades at point (c). As shown in Fig. 8, the avalanche multiplication gain increases for about 2 ns until saturated. So, the avalanche current obtains a larger gain when the photon arrives at the rising edge of the electric gate than that at the falling edge. Therefore, a large multiplication gain is good for PNR performance before the InGaAs/InP APD is saturated.
Photon count rate as a function of the laser pulse delay
Distribution of the peak output of the avalanche pulses at points (a), (b), and (c), respectively, where the detected mean photon numbers are 1.33, 1.35, and 1.32, respectively
The single-photon frequency up-conversion can be considered as the sum-frequency generation (SFG) process as shown in Fig. 14. Suppose that the pump laser is in the single longitudinal mode. The solution to the coupled-mode equations for the phase-matched interaction is given by (Kumar, 1990):
where
where
The complete quantum conversion demands a large nonlinearity of the nonlinear media together with a strong pump field. Thus, periodically poled lithium niobate (PPLN) is usually employed in the single-photon frequency up-conversion since it has a large nonlinear coefficient (
Schematic of single-photon frequency up-conversion
For single-photon frequency up-conversion, one of the key parameters is the signal to noise ratio. If the noise is much larger than the signal photons, it will be meaningless to take the trouble to do the up-conversion. Therefore, suppressing the noise will much improve the performance of the single-photon frequency up-conversion in the applications. Figure 15 shows the possible noise sources in the intracavity enhanced up-conversion system discussed in the section above. The dark counts from the Si-APD SPD (10~200 counts per second depending on the device) could be neglected since the dark counts from the background photons are much larger. The main contribution to the background photons comes from the strong pump field. The background photons at 808 and 1064 nm comes from the solid-state laser itself. Besides the up-conversion process with the incident single photons, other nonlinear effects also takes place in the nonlinear media, such as second harmonic generation (SHG) of the pump laser at 532 nm and the optical parametric generation (OPG) fluorescence. These background photons could be removed by the filter system since they are at different wavelengths from the signal photons. However, among the background photons, there are some of the same wavelengths with the signal photons at 631 nm. They are caused by up-conversion of the parametric fluorescence caused by the strong pump field. At first, spontaneous down-conversion of the strong pump took place in the nonlinear media as ω1064nm=ω1550nm+ω3400nm
Several groups have proposed the long-wavelength pump scheme to overcome the troublesome up-converted parametric fluorescence (Langrock et al., 2004; Dong et al., 2008; Kamada et al., 2008). By choosing a comparatively long-wavelength pump, which means the energy of the pump photons is lower than that of the signal photons, the parametric fluorescence from the down conversion will not fall in the incident infrared signal photon spectral regime. As a result, the pump induced parametric fluorescence can be efficiently suppressed and the dark counts will be greatly lowered. We have demonstrated an efficient single-photon frequency up-conversion system for the infrared photons at 1064 nm with ultralow dark counts (Dong et al., 2008). The pump source was provided by a mode-locked erbium-fiber laser. The repetition rate of the pulse train was 15.8 MHz and the pulse duration was measured to be 1.4 ps. The average output power of the amplifier was measured to be 27 mW. The peak power of the pulsed laser was ~220 W, high enough to achieve unity conversion efficiency in the system. With such a pulsed pump source, no cavity enhancement was required, much simplifying the whole system. A long-pass filter with 1000 nm cutting off was placed in front of the PPLN crystal to block the stray light from the erbium doped fiber amplifier (EDFA), such as the pump for the EDFA from the LD at 980 nm and the green and red up-conversion emission of the EDFA. In this long-wavelength pump system, the relatively lower energy pump photon would not induce undesired parametric fluorescence at the signal wavelength 1550 nm, and the dark counts at SFG wavelength from followed up-conversion of the parametric fluorescence was eliminated. Moreover, besides that the Si-APD SPD did not respond to pump light at 1550 nm, the up-conversion fluorescence by the second harmonic of the strong pump was not phase matched at this working temperature, thus the noise from that process could also be ignored. Thanks to sufficient suppression of the intrinsic background photons, the narrow bandpass filter was even not necessary in the filtering system, increasing the transmittance of the filtering system. After the filtering system, we measured the dark counts of the whole detection system and got a count rate of ~150 counts per second, when there were neither signal nor pump photons feeding. Moreover, when there was pump feeding, the dark count rate was still around 150 counts per second, indicating that the dark counts were not from the nonlinear parametric processes caused by the strong pump but mainly due to dark counts of Si-APD SPD and ambient background light. With this system, we achieved so far the lowest noise to efficiency ratio of ~160 for a near unity conversion efficiency (93%) as shown in Fig. 16.
The single-photon frequency up-conversion has not only shown a solution to the sensitive detection of the infrared weak signals but also provided a technique to manipulate quantum states of the photons. Novel ideas on the techniques for single-photon frequency up-conversion come forth from time to time, highlighting its applications in the quantum information processing.
Noise of the intracavity single-photon up-conversion
Schematic of the long-wavelength pumped frequency up-conversion
Different from the most methods to amplify the photo-excited carrier with a large internal electric multiplication gain by electronic devices, we employed the optical devices to amplify the few-photon before detecting by a conventional PIN photodiode. Interestingly, the photodiode response showed a linear dependence on the incident photon signals, promising a novel few-photon detection technique.
Single-photon amplification by stimulated emission becomes the focus of research interest in recent years due to its application in quantum cloning (Simon et al., 2000; Fasel et al., 2002). In order to detect the amplified photon signals with conventional PIN photodiodes, the amplifier should be chosen under the constraint of a high gain. In addition, the amplifier noise due to the spontaneous emission should be suppressed enough to allow the identification of photons due to the stimulated emission. Er-doped optical fibers are commonly used in the optical fiber communication as amplifiers due to their large gain up to 40 dB around 1550 nm. But the spontaneous emission always accompanies the stimulated emission and will be amplified as well, which would be the big barrier to identify the signal photons from the noise. In order to suppress the amplified spontaneous emission (ASE), we separated the amplification into two steps. Figure 17(a) shows the setup of the external-gain photodetector based on the single-photon amplification. The light source is a laser diode modulated by an intensity modulator at 25.0 MHz with pulse duration of 325 ps. The output spectrum of the laser is shown by the green line in Fig. 18(b). The central wavelength is at 1550.20 nm and the full width at half maximum (FWHM) is 0.02 nm. The output of the laser is attenuated to contain only a few photons per pulse. Then, the photons are sent to the first EDFA for amplification. In order to detect the stimulated emission photons, spectral filtering is necessary because the ASE spectrum of the EDFA covered a broad range from 1527.36 to 1563.84 nm. Firstly, an inline bandpass filter (IF1) centered at 1550 nm with the FWHM of 3 nm is inserted to roughly extract the amplified signal photons from the broadband fluorescence.
Secondly, the combination of the two fiber Brag gratings (FBG1, 2) with the FWHM of 0.18 nm form another bandpass filter. By tuning the temperature to combine the rising edge of FBG1 and the falling edge of FBG2, a final bandwidth of the bandpass filter was determined to be 0.06 nm. Finally, a fiber polarization controller (PC) together with a polarization beam splitter (PBS) helps to remove the ASE noise of the orthogonal polarization. Then, the optical signal is sent to another EDFA for the amplification again. Since the incident photons are pre-amplified while most of the ASE noise is removed before the second amplification, the ASE of the second EDFA itself is much suppressed and instead the stimulated amplification is enhanced. Spectral filtering is not as strict as in the first step. The filtering system for the second amplification is composed of a bandpass inline filter (IF2) with the FWHM of 3 nm and a fiber Brag grating FBG3 with the FWHM of 0.18 nm. The PBS is not even necessary in the second step because the ASE of the orthogonal polarization in the second EDFA is so weak that it could be ignored. The black line in Fig. 17(b) shows the ASE spectrum after the two-step amplification. The spectral width is mainly constrained by the combined FBG filters in the first step. When the signal photons are sent in, the peak at 1550.20 nm raises on the top of the ASE spectrum as shown by the red line in Fig. 17(b), indicating the stimulated amplification of the incident photons. The total gain of the two EDFAs is measured separately to be about 42.7 dB, indicating that an incident photon could be amplified to ~104 photons per pulse (about 1 mW of the peak power) after the two-step amplification. The optical pulse signal is detected by a PIN photodiode. The variance of the ASE noise is measured and plotted as a function of the ASE output power as shown in Fig. 17(c). Since the main voltage noise is derived from the ASE beat on the PIN photodiode, the variance of the noise increased nonlinearly with the average output power, indicating that the ASE noise could be considered as a classical noise. The voltage noise amplitude is in Gaussian distribution with an FWHM of ~140 mV (Fig. 17(d)).
Figure 18 plots the color-grading waveforms of the output voltage measured by the DPX acquisition mode of a 2.5-GHz oscilloscope with an average incident photon number of μ = 4 and 16. From the oscilloscope traces, it is observed that the peak output signal amplitude changes with the incident photon numbers, showing the evidence of the photon number resolving ability of the detector. The amplitude of the peak output signal shows a linear dependence on the input average photon number as shown in Fig. 20, indicating that the EDFAs and the photodiode are far from saturation under such milliwatt optical input power and capable of registering more than 16 individual photons. By taking into account the optical amplification, the photodiode response and the electronic amplification, the sensitivity of the whole setup is obtained by fitting the curve in Fig. 19 to be 15.39 mV/photon.
The photon statistics is studied by analyzing the histograms of the voltage signal acquired by the oscilloscope. The temporal resolution of oscilloscope is set to 100 ps, and the voltage amplitude resolution is set to 4 mV. A 500-ps sampling window is used in the analysis. Figure 20 plots the histograms of the peak output signal voltage recorded for different incident photon numbers of μ = 4 and 16 per pulse. The red lines in Fig. 21 show a simulation of the experimental data assuming a Poisson distribution for the incident photons. Due to the ASE noise variance, the distribution histograms are broadened, dimming the boundary for different photon numbers. By taking into account the Poisson distribution of the incident photons, the single photon response of the system is obtained to be 68 mV by fitting the curves in Fig. 20, and the quantum efficiency of the EDFAs is calculated to be 22.7%. Due to the linearity of the external-gain photodetector, the curves of the peak voltage kept the shapes of the ideal Poisson distribution of the input photons. The probability statistics of the peak output voltage could be also observed in Fig. 18 directly by its color-grading.
a) Schematic of the external-gain detector, where IF1,2: inline filters, FBG1-3: fiber Bragg gratings, Cir1-3: fiber circulators, PC: polarization controller, PBS: polarization beam splitter, PD: conventional pin photodiode, AMP: RF amplifiers. (b) Spectra of the laser (blue), ASE of the EDFA (green) and amplified single-photon signal (red). (c) variance of the ASE noise with the ASE power; (d) Distribution of the peak output of one photon.
Due to the lager spontaneous emission of the EDFA, the detector cannot discriminate single-photon pulses. The FWHM of the bandpass filter is 0.06 nm as well as about 7.4 GHz. The laser pulse width is ~325 ps, corresponding to the laser bandwidth in the order of 10 GHz. The filers fits well with the laser pulse, but the insertion loss of the filters is about 15dB, most of them comes from FBG1 and FBG2. So, more efforts are needed to suppress the spontaneous emission to decrease the insertion loss. However, the detector can be used as a sensitive power meter at single-photon lever, as the integral output has a good linearity to the input photon number, while the noise is averaged.
Waveforms of the voltage output recorded by the oscilloscope with incident photon number of (a) 4 and (b) 16.
Peak output voltage of the amplified photon signals and ASE noise variance. (a) Average peak amplitude as a function of the incident photon number. (b) ASE noise variance dependent on the output power.
Distributions of peak output signal for incident pulses of different average photon numbers, together with the calculated distributions
InGaAs/InP APDs are typically operated in gated Geiger mode for near-infrared single-photon detection. The afterpulsing effect becomes the major obstacle for high speed detection with the gating rate > 200 MHz, which should use short gating width (e.g. ~1 ns). The capacitive response of the InGaAs/InP APD must be cancelled to distil the weak avalanche pulse. We introduce three kinds of capacitive-response cancellation techniques, where the balanced capacitance cancellation technique is robust for operation at the gating rate < 200-MHz; and the self-cancellation and optical self-cancellation techniques are effective in higher gating rate up to 2 GHz. On the other hand, InGaAs/InP APDs are operated in non-saturated Geiger mode when the gating width < 2 ns. In this mode, the output of the InGaAs/InP APD is proportional to the input photon number. And we prove that the PNR performance is determined by the multiplication gain of the InGaAs/InP APD and input time of the photons.
Optical techniques are potential to realize high performance near-infrared single-photon detection. One of them is the single-photon frequency up-conversion. The major problem of up-conversion is the background photons induced by the optical nonlinear process, which could be resolved by using long-wavelength pump laser, and the background photons are suppressed at a negligible level. The other optical technique is just starting that detects few-photon pulse with a conventional linear photodiode after amplified by an external optical amplifier. Up to now, it still need efforts to realize an ultra-low noise optical amplifier for few-photon detection.
This work was funded, in part, by the National Natural Science Fund of China (10904039, 10525416, 10990101, and 91021014), Key Project Sponsored by the National Education Ministry of China (108058), Research Fund for the Doctoral Program of Higher Education of China (200802691032), and Shanghai Rising-Star Program (10QA1402100).
Aphasia is an acquired communication impairment that impacts the ability to speak, understand, read, write, and carry out mathematical calculations [1]. It is caused by damage to the language networks in the brain usually after stroke but not only [2]. Aphasia is linked to poorer functional recovery [3], return to work [4], activities of daily living [5], depression [6], and social isolation [7].
Functional communication and social participation are impaired in aphasia, which brings about reduced confidence in communication [8]. This leads to reduced interactions with family and friends [9] and smaller social networks [10]. Although maintaining social interactions and friendship networks in the chronic phase of aphasia (greater than 6-months post brain injury) has been identified as an important goal in aphasia rehabilitation, this is not regularly addressed by aphasia clinicians [9].
Historical models of aphasia assessment and treatment have focused mainly on the person’s linguistic competence [11]. Even though people with aphasia (PWA) may have successfully achieved their therapeutic goals in individual speech and language therapy sessions, they still struggle to use their new communication skills successfully in natural environments, e.g., with family members, close friends, and their therapist outside of the clinic/treatment environment [12]. Contemporary rehabilitation approaches pay increasing attention to the pragmatic competence and the overall functionality of communication of PWA via aphasia communication groups (ACGs) [13].
In the context of the International Classification of Functioning, Disability and Health (ICF) [14], biopsychosocial models of disability, and particularly the Life Participation Approach to Aphasia Project Group [15], interest in ACGs is increasing in both research and clinical settings [16]. ACGs provide psychosocial benefits to PWA, including increasing social participation and peer support [17].
While ACGs can focus on the impairment-based characteristics of aphasia, the nature of the group setting tends to elicit functional, naturalistic forms of communication [20]. The actions and subject matter of each communication group vary enormously and depend mainly on the goals and aspirations of the group members. Group members develop close relationships with each other in a natural and supporting environment, which promotes meaningful conversations with people who empathize with their difficulties.
The primary
Loneliness and social inaccessibility in chronic aphasia lead to poor community and public engagement [9]. Aphasia communication groups are an opportunity for social participation [28] that promote community integration, broaden friendship circles, and improve social connectedness [29]. Without prospects for
Aphasia communication groups’ positive participation promotes
Before establishing an ACG, members should discuss and agree on the group’s ground rules using a SIMPLE approach. The ACG and each group member should be:
The general inclusion criteria for
are living in the community.
have been discharged from acute and sub-acute rehabilitation.
are in the chronic stage of aphasia.
do not need additional medical support while being at the group.
have given written informed consent to participate.
have signed a confidentiality contract so they do not share the personal experiences and narratives of other group members with people outside the group.
present with various types and severities of aphasia.
The inclusion criteria are usually adjusted according to the setting and the purpose of each ACG [21].
A successful group requires several features to be efficient: the members, the group, and the tasks/activities, the context [34]:
The
work cooperatively and not competitively.
support each other and show empathy.
get rewarded collectively and not individually.
are aware of the nature of the group process.
The
is relatively small (maximum five people).
is autonomous to address its activities and tasks.
has an effective leader/facilitator.
operates in the context of a supportive organization or community.
The
are accessible to all members.
are designed considering the individual skills of each member.
promote the active engagement of all members.
have precise objectives.
have a beginning and a defined end.
have measurable indicators of success.
The
The physical environment should be accessible.
Time schedule and agenda should be defined.
Resources should be allocated before enrolment.
External factors should be taken into consideration (traveling, financial issues).
Group members practice total communication skills, i.e., gestures, singing, drawing, and writing, and/or a combination of all the above [20]. The main topics of discussion are learning about/refreshing knowledge on stroke and aphasia, linking the information to members’ own experiences, asking questions, and discussing living with stroke and aphasia [21]. It is also important for members to share stories about life before the stroke [35]. Resources for total communication such as writing boards, notebooks, tables, communication books, aphasia friendly materials [36], and the Internet should be used to access information online [37].
Group meetings can be established with face-to-face contact or digitally. Virtual group meetings and videoconferencing are a growing trend in aphasia rehabilitation with a major impact [38]. Online groups favor the person with mild to moderate aphasia, the member who is well motivated to participate and seeks interaction despite the means. In online ACGs, it is mandatory that members know how to operate a tablet, mobile phone, or a laptop independently and understand the ethics and procedures behind video conferencing [39]. Realistically, ACGs via video conferencing compared to face-to-face interaction need more time to plan and prepare. When technical problems occur, and they often do occur, they cause anxiety and frustration to the group. Some members become diverted into “fixing” the problem where others “switch off” from participating, factors that make the interaction dysfunctional. The experience of engaging in an online meeting is more mentally demanding as members must concentrate simultaneously on the content of the meeting, the visual material, and the constant input from several sources. Additionally, nonverbal cues are not detected easily, and the facilitator must be proactive in giving cues and prepare digital material to promote engagement.
According to Worrall and colleagues [40], goal setting in ACGs with PWA can be challenging because of members:
strain in understanding the
feelings of
A further challenge is related to the
At the beginning of each ACG, goals are discussed with the members of the group, which are more likely to be their long-term goals for aphasia rehabilitation in general. The facilitator along with the communication buddies needs to support the members of the group to break down these goals into SMART short-term goals that can be addressed in the group. These goals should be SMART: Specific, Measurable, Attainable, Relevant, and Time-based (Figure 1).
Setting SMART goals in ACGs.
In combination with the SMART goals, the SMARTER “Shared, Monitored, Accessible, Relevant, Transparent, Evolving, Relationship” framework encourages aphasia rehabilitation specialists engaged in group therapy to share the goal-setting process with the person with aphasia [41]. The procedure of setting SMARTER goals should be accomplished in a way that is accessible to the members of the group and ensures that the goals evolve with the needs of the clients. Within this framework, the person with aphasia is actively engaged in monitoring their own progress on the goals and each activity in the group ensuring transparency (see Figure 2). All goals are relevant to the person with aphasia, and care is provided in a way that builds rapport within the group. Personalized and qualitative therapeutic objectives enable group members to gain more insight into their communication barriers, individually and within the group.
The SMARTER framework based on Hersh et al. [
For ACGs to achieve a SMARTER goal setting, the facilitator must read through the framework extensively and then answer the questions for each domain reported below in Table 1 c.
YES | NO | |
---|---|---|
Shared | ||
| ||
Relationship-Centered | ||
| ||
Relevant | ||
| ||
Accessible | ||
| ||
Transparent | ||
| ||
Monitored | ||
| ||
Evolving | ||
|
Specific questions involved in SMARTER goal setting framework as adapted from Hersh et al. [41].
A communication buddy is a communication and conversation partner assigned for each person with aphasia within the group. Their main goal is to facilitate the understanding and output (not necessarily verbal) for PWA within the group. Communication buddies should establish mutual support, promote learning about aphasia, facilitate communication, and promote communication skills enhancement [21]. Pairing in groups is based on Bion’s theory of “containment” or “container and contained.” According to Bion, the
The “essential” people that makeup
Communication buddies can be:
health care professionals.
allied health rehabilitation students, e.g., speech and language therapy students.
the client’s carer, a family member, or friend.
volunteers from aphasia and stroke support organizations.
Communication buddies should be identified and assigned by the person with aphasia or by the setting where the group is taking place, e.g., students in a university setting. Communication access, social contact, and active participation are crucial elements in aphasia group work. The person with aphasia, the group facilitator, and the communication buddy must collaborate to find the means and strategies that are most useful for the particular client during communication breakdowns. These may include gestures, drawing, picture support, simplified text, writing keywords, clarification statements, verification questions, eliminating environmental distractors, and summarizing (see Table 2). It is mandatory to work closely as a team to identify and tailor these strategies to the person with aphasia.
Means and strategies | Description |
---|---|
Gestures | Hand and body movements to express a meaning |
Drawing | A picture or a diagram to represent a word or a meaning |
Picture support | The use of a picture that can support understanding of the topic |
Simplified text | A process to simplify a written message’s content by paraphrasing |
Writing keywords | The use of important/concept words to promote understanding |
Clarification statements | To explain something in more detail to clarify the meaning |
Verification questions | To ask yes/no or simple questions to confirm understanding |
Environmental distractors | Things in the environment that move, make noise, or vibrate |
Summarizing | To give a brief statement of the main points |
The means and strategies for communication recovery.
It is crucial that communication buddies, before their involvement with the group [41]:
receive
watch videos and work on communication repair (i.e., how to modify, repeat or revise a message when the first communication attempt has failed) and facilitation strategies (i.e., active listening, good preparation, prompting, visual and verbal cues).
receive
It is mandatory that communication partners learn how to implement the communication strategies within the group, communicate their message in simplified and accessible ways and assist the person with aphasia to get their message across [43].
Peer-led support groups for PWA are run by a person with aphasia and/or family member, with the assistance of their communication buddies, which aim to increase social interaction and peer support [44]. Peer-led models in aphasia communication groups provide access to constant peer support and may address some of the limitations of professionally-led support groups that may use formal agendas and have a strict group structure [45].
Studies examining peer-led support groups in other chronic conditions, that is, cancer survivors, have shown peer-led support groups (72.1%) are greater in the community than professionally led support groups (27.9%) [46], and there is a larger preference for peer than professional health care leaders [47]. For example, by reducing professional resources and interventions, peer-led ACGs can provide extensive, long-term opportunities for functional communication, social contact, friendship, and peer support [48]. Aphasia Connect has successfully expanded the range of services available for PWA across the UK by utilizing PWA as service providers (group leaders) as well as receivers (group members) [49]. Additionally, members of peer-led ACGs share a greater sense of empowerment and ownership as they provide
Tregea and Brown [45] found that the features that are important for the successful functioning of a peer-led aphasia support group are:
Additional factors that facilitated peer leaders to start and run groups include informational support, practical support, attracting new members, time, venue and organization, and a pleasant communicative personality [45].
Aphasia communication group facilitators should not necessarily be qualified SLTs but individuals who have been trained by professional SLTs and/or the research team, in case the group is part of a randomized controlled trial (RCT), ahead of the intervention or trial, with a particular focus on meaningful and effective communication with PWA [49]. Facilitators should be provided the National Aphasia Guidelines [50] for communication with PWA and be trained on partner conversation skills [43]. Facilitators should assist PWA to co-facilitate the group, and complete checklists at the end of each group session to evaluate fidelity to group content [49]. In a recent pilot feasibility RCT by Tarrant et al. [51] examining group signing intervention in PWA, the facilitators identified several benefits that they attributed to the intervention, starting with the prospect for PWA to meet peers and share personal experiences and the development of warm, empathetic friendships.
In contemporary clinical aphasiology, facilitated conversation in aphasia communication groups is a popular exercise but only a small number of published studies have documented how interactions occur in such group settings [51, 52]. One aspect of ACGs that has been mentioned in the recent literature, but that has not yet been the focus of intensive study, is participation management [51]. Facilitators report that finding ways to help people with limited expressive language participate in the conversation and the group, in general, is one of the central challenges faced by the clinicians and volunteers who lead these groups [51, 52, 53].
The study of Archer and colleagues [52] documents common approaches to assisting PWA to participate meaningfully within the group discussions. Results revealed a set of conversational practices used by facilitators and by group members with verbal output difficulties. Archer et al. [52] stated that “these practices took the form of two sequences viz. floor transfers and question-answer series” (p. 15). The identified sequences contributed to promoting meaningful conversational participation by group members with non-fluent aphasia.
After a national survey of third sector ACGs facilitators in the UK by VandenBerg et al. ([54], p. 25), results revealed that the factors described as important to supporting members’ attendance in aphasia support groups were as follows:
A kind induction (29%);
Members’ confidence in their communication skills (24%); and.
Positive group dynamics (23%).
Also, in the same study ([54], p. 25), facilitators indicated that motivators for PWA’s attendance were prioritized by their communication needs:
“To get better at communicating” (16%);
“To feel confident talking” (13%);
“Meeting other people with aphasia” (18%).
“Over peer support” (10%).
or “Emotional support” (8%).
Aphasia communication groups offer many advantages over traditional individual therapy models in the chronic stage [55]:
Group evaluation has three fundamental purposes [57]:
To proceed with an evaluation process of the ACG, one could choose to evaluate all or any of the following areas [19]:
The objectives: Were the goals appropriate to the needs of the group? Were the goals sufficiently adapted to the individual needs of the group members?
The TACT is a university-affiliated ACG in the Republic of Cyprus. The number of strokes in Cyprus range between 1200 and 1400 yearly [58]. If one considers a third of all stroke survivors have aphasia, this means, there are roughly 400 new cases of aphasia each year. About 61% continue to experience communication problems 1 year after stroke leading to fewer friendships and smaller social networks [59]. In the exploration of all the above factors influenced by aphasia, the idea of The Aphasia Communication Team – TACT emerged. TACT delivers benefits to PWA, families, and speech-language therapy trainees. TACT aims to provide stroke survivors support for learning and communication opportunities to promote living well with aphasia. TACT works on the barriers (areas of weakness of the person with aphasia and conversation partners that make communication difficult) and on what communication tools members could use to improve communication. TACT has a broad outlook for living well with aphasia and improving quality of life. Another goal targeted is the understanding that aphasia can be a long-term condition and that aphasia is a “family issue”—not just for the person with aphasia [60]. TACT promotes full participation and engagement in activities of interest. TACT encourages a safe, positive, environment, and is inclusive to all.
The Cyprus Stroke Association recruits stroke survivors and TACT is held at the premises of the Rehabilitation Clinic of the Cyprus University of Technology once a week, for 2 hours. Two groups have been established so far, with five stroke survivors with chronic aphasia and five communication buddies, for each group. Communication buddies are speech and language therapy students who serve as communication facilitators of each group member. The groups are supervised and coordinated by academic and scientific staff from the Department of Rehabilitation Sciences.
are discharged from formal rehabilitation [53].
have terminated individual speech and language therapy sessions [34].
aphasia is a predominant communication difficulty in relation to possible apraxia of speech or dysarthric symptoms [20].
can sustain approximately 2-hour participation with the group.
present with different severities of aphasia [18].
do not need additional medical support while being at group [55].
should manage toileting or have additional support from a carer [34].
have given written consent to participate and sign a confidentiality contract with the clinic and CSA.
Group members are assessed on psychometric measures (language, cognition, and quality of life) at the beginning and the end of each block of therapy. Therapy consists of a 12-week block of weekly sessions. The assessment procedure is based on the International Population Registry for Aphasia after Stroke (I-PRAISE) protocol [61] in combination with Attard et al’s. [53] ICF-based assessment protocol. This is deemed necessary to measure improvement or change in behaviors post-therapy (see Table 3).
ICF domain-outcome measures | |
---|---|
Aphasia impairment |
|
Activity & participation |
|
Contextual Factors |
|
Quality of life |
|
Psychological health |
|
ACGs outcome measures.
Group members are encouraged to share experiences by using technology and tablets. They also practice total communication skills, i.e., adding gestures, drawing, and writing to speech. The main topics of discussion are acquiring new knowledge on stroke and aphasia, linking the data to members’ personal experiences, clarifying questions and misunderstandings about their condition, and sharing stories about their life before stroke, the incidence itself, and living with aphasia (see Figure 4).
The main conversation “topics” for TACT members.
Group member’s outcomes consist of change or improvement in measures of functional communication, the overall severity of language impairment, auditory comprehension, spoken language (including naming), reading, and writing from baseline, overall communication self-rating, and quality of life after stroke. Data gathered via assessment procedures are digitalized for each individual member on a database using the RELEASE protocol [61]. The use of the communication buddy system, the involvement of the total communication approach, the systematic assessment, and the collection of individual patient data (IPD) sets enable the TACT team to measure the effectiveness and efficacy of group therapy interventions for people with chronic aphasia in terms of use of functional communication, social inclusion [14], and quality of life [31].
There is no doubt that Aphasia Communication Groups (ACGs) are of great benefit for people with chronic aphasia. ACGs are associated overall with improvement in communication, social networks, and community access. To achieve this, ACGs facilitators, participating members, and communication buddies should have equal involvement in the realization of the group.
The authors declare no conflict of interest.
IntechOpen publishes different types of publications
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\n\nRESEARCH CHAPTER – A research chapter reports the results of original research thus contributing to the body of knowledge in a particular area of study.
\n\nREVIEW CHAPTER – A review chapter analyzes or examines research previously published by other scientists, rather than reporting new findings thus summarizing the current state of understanding on a topic.
\n\nCASE STUDY – A case study involves an in-depth, and detailed examination of a particular topic.
\n\nPERSPECTIVE CHAPTER – A perspective chapter offers a new point of view on existing problems, fundamental concepts, or common opinions on a specific topic. Perspective chapters can propose or support new hypotheses, or discuss the significance of newly achieved innovations. Perspective chapters can focus on current advances and future directions on a topic and include both original data and personal opinion.
\n\nINTRODUCTORY CHAPTER – An introductory chapter states the purpose and goals of the book. The introductory chapter is written by the Academic Editor.
\n\nMonographs is a self-contained work on a particular subject, or an aspect of it, written by one or more authors. Monographs usually have between 130 and 500 pages.
\n\nTYPES OF MONOGRAPHS:
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\n\nCompacts provide a mid-length publishing format that bridges the gap between journal articles, book chapters, and monographs, and cover content across all scientific disciplines.
\n\nCompacts are the preferred publishing option for brief research reports on new topics, in-depth case studies, dissertations, or essays exploring new ideas, issues, or broader topics on the research subject. Compacts usually have between 50 and 130 pages.
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Buchholz and Erik J. Behringer",hash:"e373a3d1123dbd45fddf75d90e3e7c38",volumeInSeries:1,fullTitle:"Calcium and Signal Transduction",editors:[{id:"89438",title:"Dr.",name:"John N.",middleName:null,surname:"Buchholz",slug:"john-n.-buchholz",fullName:"John N. Buchholz",profilePictureURL:"https://mts.intechopen.com/storage/users/89438/images/6463_n.jpg",institutionString:null,institution:{name:"Loma Linda University",institutionURL:null,country:{name:"United States of America"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Plant Physiology",value:13,count:1},{group:"subseries",caption:"Human Physiology",value:12,count:2},{group:"subseries",caption:"Cell Physiology",value:11,count:8}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:1},{group:"publicationYear",caption:"2020",value:2020,count:4},{group:"publicationYear",caption:"2019",value:2019,count:5},{group:"publicationYear",caption:"2018",value:2018,count:1}],authors:{paginationCount:302,paginationItems:[{id:"198499",title:"Dr.",name:"Daniel",middleName:null,surname:"Glossman-Mitnik",slug:"daniel-glossman-mitnik",fullName:"Daniel Glossman-Mitnik",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/198499/images/system/198499.jpeg",biography:"Dr. Daniel Glossman-Mitnik is currently a Titular Researcher at the Centro de Investigación en Materiales Avanzados (CIMAV), Chihuahua, Mexico, as well as a National Researcher of Level III at the Consejo Nacional de Ciencia y Tecnología, Mexico. His research interest focuses on computational chemistry and molecular modeling of diverse systems of pharmacological, food, and alternative energy interests by resorting to DFT and Conceptual DFT. He has authored a coauthored more than 255 peer-reviewed papers, 32 book chapters, and 2 edited books. He has delivered speeches at many international and domestic conferences. He serves as a reviewer for more than eighty international journals, books, and research proposals as well as an editor for special issues of renowned scientific journals.",institutionString:"Centro de Investigación en Materiales Avanzados",institution:{name:"Centro de Investigación en Materiales Avanzados",country:{name:"Mexico"}}},{id:"76477",title:"Prof.",name:"Mirza",middleName:null,surname:"Hasanuzzaman",slug:"mirza-hasanuzzaman",fullName:"Mirza Hasanuzzaman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/76477/images/system/76477.png",biography:"Dr. Mirza Hasanuzzaman is a Professor of Agronomy at Sher-e-Bangla Agricultural University, Bangladesh. He received his Ph.D. in Plant Stress Physiology and Antioxidant Metabolism from Ehime University, Japan, with a scholarship from the Japanese Government (MEXT). Later, he completed his postdoctoral research at the Center of Molecular Biosciences, University of the Ryukyus, Japan, as a recipient of the Japan Society for the Promotion of Science (JSPS) postdoctoral fellowship. He was also the recipient of the Australian Government Endeavour Research Fellowship for postdoctoral research as an adjunct senior researcher at the University of Tasmania, Australia. Dr. Hasanuzzaman’s current work is focused on the physiological and molecular mechanisms of environmental stress tolerance. Dr. Hasanuzzaman has published more than 150 articles in peer-reviewed journals. He has edited ten books and written more than forty book chapters on important aspects of plant physiology, plant stress tolerance, and crop production. According to Scopus, Dr. Hasanuzzaman’s publications have received more than 10,500 citations with an h-index of 53. He has been named a Highly Cited Researcher by Clarivate. He is an editor and reviewer for more than fifty peer-reviewed international journals and was a recipient of the “Publons Peer Review Award” in 2017, 2018, and 2019. He has been honored by different authorities for his outstanding performance in various fields like research and education, and he has received the World Academy of Science Young Scientist Award (2014) and the University Grants Commission (UGC) Award 2018. He is a fellow of the Bangladesh Academy of Sciences (BAS) and the Royal Society of Biology.",institutionString:"Sher-e-Bangla Agricultural University",institution:{name:"Sher-e-Bangla Agricultural University",country:{name:"Bangladesh"}}},{id:"187859",title:"Prof.",name:"Kusal",middleName:"K.",surname:"Das",slug:"kusal-das",fullName:"Kusal Das",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSBDeQAO/Profile_Picture_1623411145568",biography:"Kusal K. Das is a Distinguished Chair Professor of Physiology, Shri B. M. Patil Medical College and Director, Centre for Advanced Medical Research (CAMR), BLDE (Deemed to be University), Vijayapur, Karnataka, India. Dr. Das did his M.S. and Ph.D. in Human Physiology from the University of Calcutta, Kolkata. His area of research is focused on understanding of molecular mechanisms of heavy metal activated low oxygen sensing pathways in vascular pathophysiology. He has invented a new method of estimation of serum vitamin E. His expertise in critical experimental protocols on vascular functions in experimental animals was well documented by his quality of publications. He was a Visiting Professor of Medicine at University of Leeds, United Kingdom (2014-2016) and Tulane University, New Orleans, USA (2017). For his immense contribution in medical research Ministry of Science and Technology, Government of India conferred him 'G.P. Chatterjee Memorial Research Prize-2019” and he is also the recipient of 'Dr.Raja Ramanna State Scientist Award 2015” by Government of Karnataka. He is a Fellow of the Royal Society of Biology (FRSB), London and Honorary Fellow of Karnataka Science and Technology Academy, Department of Science and Technology, Government of Karnataka.",institutionString:"BLDE (Deemed to be University), India",institution:null},{id:"243660",title:"Dr.",name:"Mallanagouda Shivanagouda",middleName:null,surname:"Biradar",slug:"mallanagouda-shivanagouda-biradar",fullName:"Mallanagouda Shivanagouda Biradar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243660/images/system/243660.jpeg",biography:"M. S. Biradar is Vice Chancellor and Professor of Medicine of\nBLDE (Deemed to be University), Vijayapura, Karnataka, India.\nHe obtained his MD with a gold medal in General Medicine and\nhas devoted himself to medical teaching, research, and administrations. He has also immensely contributed to medical research\non vascular medicine, which is reflected by his numerous publications including books and book chapters. Professor Biradar was\nalso Visiting Professor at Tulane University School of Medicine, New Orleans, USA.",institutionString:"BLDE (Deemed to be University)",institution:{name:"BLDE University",country:{name:"India"}}},{id:"289796",title:"Dr.",name:"Swastika",middleName:null,surname:"Das",slug:"swastika-das",fullName:"Swastika Das",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/289796/images/system/289796.jpeg",biography:"Swastika N. Das is Professor of Chemistry at the V. P. Dr. P. G.\nHalakatti College of Engineering and Technology, BLDE (Deemed\nto be University), Vijayapura, Karnataka, India. She obtained an\nMSc, MPhil, and PhD in Chemistry from Sambalpur University,\nOdisha, India. Her areas of research interest are medicinal chemistry, chemical kinetics, and free radical chemistry. She is a member\nof the investigators who invented a new modified method of estimation of serum vitamin E. She has authored numerous publications including book\nchapters and is a mentor of doctoral curriculum at her university.",institutionString:"BLDEA’s V.P.Dr.P.G.Halakatti College of Engineering & Technology",institution:{name:"BLDE University",country:{name:"India"}}},{id:"248459",title:"Dr.",name:"Akikazu",middleName:null,surname:"Takada",slug:"akikazu-takada",fullName:"Akikazu Takada",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248459/images/system/248459.png",biography:"Akikazu Takada was born in Japan, 1935. After graduation from\nKeio University School of Medicine and finishing his post-graduate studies, he worked at Roswell Park Memorial Institute NY,\nUSA. He then took a professorship at Hamamatsu University\nSchool of Medicine. In thrombosis studies, he found the SK\npotentiator that enhances plasminogen activation by streptokinase. He is very much interested in simultaneous measurements\nof fatty acids, amino acids, and tryptophan degradation products. By using fatty\nacid analyses, he indicated that plasma levels of trans-fatty acids of old men were\nfar higher in the US than Japanese men. . He also showed that eicosapentaenoic acid\n(EPA) and docosahexaenoic acid (DHA) levels are higher, and arachidonic acid\nlevels are lower in Japanese than US people. By using simultaneous LC/MS analyses\nof plasma levels of tryptophan metabolites, he recently found that plasma levels of\nserotonin, kynurenine, or 5-HIAA were higher in patients of mono- and bipolar\ndepression, which are significantly different from observations reported before. In\nview of recent reports that plasma tryptophan metabolites are mainly produced by\nmicrobiota. He is now working on the relationships between microbiota and depression or autism.",institutionString:"Hamamatsu University School of Medicine",institution:{name:"Hamamatsu University School of Medicine",country:{name:"Japan"}}},{id:"137240",title:"Prof.",name:"Mohammed",middleName:null,surname:"Khalid",slug:"mohammed-khalid",fullName:"Mohammed Khalid",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/137240/images/system/137240.png",biography:"Mohammed Khalid received his B.S. degree in chemistry in 2000 and Ph.D. degree in physical chemistry in 2007 from the University of Khartoum, Sudan. He moved to School of Chemistry, Faculty of Science, University of Sydney, Australia in 2009 and joined Dr. Ron Clarke as a postdoctoral fellow where he worked on the interaction of ATP with the phosphoenzyme of the Na+/K+-ATPase and dual mechanisms of allosteric acceleration of the Na+/K+-ATPase by ATP; then he went back to Department of Chemistry, University of Khartoum as an assistant professor, and in 2014 he was promoted as an associate professor. In 2011, he joined the staff of Department of Chemistry at Taif University, Saudi Arabia, where he is currently an assistant professor. His research interests include the following: P-Type ATPase enzyme kinetics and mechanisms, kinetics and mechanisms of redox reactions, autocatalytic reactions, computational enzyme kinetics, allosteric acceleration of P-type ATPases by ATP, exploring of allosteric sites of ATPases, and interaction of ATP with ATPases located in cell membranes.",institutionString:"Taif University",institution:{name:"Taif University",country:{name:"Saudi Arabia"}}},{id:"63810",title:"Prof.",name:"Jorge",middleName:null,surname:"Morales-Montor",slug:"jorge-morales-montor",fullName:"Jorge Morales-Montor",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/63810/images/system/63810.png",biography:"Dr. Jorge Morales-Montor was recognized with the Lola and Igo Flisser PUIS Award for best graduate thesis at the national level in the field of parasitology. He received a fellowship from the Fogarty Foundation to perform postdoctoral research stay at the University of Georgia. He has 153 journal articles to his credit. He has also edited several books and published more than fifty-five book chapters. He is a member of the Mexican Academy of Sciences, Latin American Academy of Sciences, and the National Academy of Medicine. He has received more than thirty-five awards and has supervised numerous bachelor’s, master’s, and Ph.D. students. Dr. Morales-Montor is the past president of the Mexican Society of Parasitology.",institutionString:"National Autonomous University of Mexico",institution:{name:"National Autonomous University of Mexico",country:{name:"Mexico"}}},{id:"217215",title:"Dr.",name:"Palash",middleName:null,surname:"Mandal",slug:"palash-mandal",fullName:"Palash Mandal",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/217215/images/system/217215.jpeg",biography:null,institutionString:"Charusat University",institution:null},{id:"49739",title:"Dr.",name:"Leszek",middleName:null,surname:"Szablewski",slug:"leszek-szablewski",fullName:"Leszek Szablewski",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49739/images/system/49739.jpg",biography:"Leszek Szablewski is a professor of medical sciences. He received his M.S. in the Faculty of Biology from the University of Warsaw and his PhD degree from the Institute of Experimental Biology Polish Academy of Sciences. He habilitated in the Medical University of Warsaw, and he obtained his degree of Professor from the President of Poland. Professor Szablewski is the Head of Chair and Department of General Biology and Parasitology, Medical University of Warsaw. Professor Szablewski has published over 80 peer-reviewed papers in journals such as Journal of Alzheimer’s Disease, Biochim. Biophys. Acta Reviews of Cancer, Biol. Chem., J. Biomed. Sci., and Diabetes/Metabol. Res. Rev, Endocrine. He is the author of two books and four book chapters. He has edited four books, written 15 scripts for students, is the ad hoc reviewer of over 30 peer-reviewed journals, and editorial member of peer-reviewed journals. Prof. Szablewski’s research focuses on cell physiology, genetics, and pathophysiology. He works on the damage caused by lack of glucose homeostasis and changes in the expression and/or function of glucose transporters due to various diseases. He has given lectures, seminars, and exercises for students at the Medical University.",institutionString:"Medical University of Warsaw",institution:{name:"Medical University of Warsaw",country:{name:"Poland"}}},{id:"173123",title:"Dr.",name:"Maitham",middleName:null,surname:"Khajah",slug:"maitham-khajah",fullName:"Maitham Khajah",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/173123/images/system/173123.jpeg",biography:"Dr. Maitham A. Khajah received his degree in Pharmacy from Faculty of Pharmacy, Kuwait University, in 2003 and obtained his PhD degree in December 2009 from the University of Calgary, Canada (Gastrointestinal Science and Immunology). Since January 2010 he has been assistant professor in Kuwait University, Faculty of Pharmacy, Department of Pharmacology and Therapeutics. His research interest are molecular targets for the treatment of inflammatory bowel disease (IBD) and the mechanisms responsible for immune cell chemotaxis. He cosupervised many students for the MSc Molecular Biology Program, College of Graduate Studies, Kuwait University. Ever since joining Kuwait University in 2010, he got various grants as PI and Co-I. He was awarded the Best Young Researcher Award by Kuwait University, Research Sector, for the Year 2013–2014. He was a member in the organizing committee for three conferences organized by Kuwait University, Faculty of Pharmacy, as cochair and a member in the scientific committee (the 3rd, 4th, and 5th Kuwait International Pharmacy Conference).",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"195136",title:"Dr.",name:"Aya",middleName:null,surname:"Adel",slug:"aya-adel",fullName:"Aya Adel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/195136/images/system/195136.jpg",biography:"Dr. Adel works as an Assistant Lecturer in the unit of Phoniatrics, Department of Otolaryngology, Ain Shams University in Cairo, Egypt. Dr. Adel is especially interested in joint attention and its impairment in autism spectrum disorder",institutionString:"Ain Shams University",institution:{name:"Ain Shams University",country:{name:"Egypt"}}},{id:"94911",title:"Dr.",name:"Boulenouar",middleName:null,surname:"Mesraoua",slug:"boulenouar-mesraoua",fullName:"Boulenouar Mesraoua",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94911/images/system/94911.png",biography:"Dr Boulenouar Mesraoua is the Associate Professor of Clinical Neurology at Weill Cornell Medical College-Qatar and a Consultant Neurologist at Hamad Medical Corporation at the Neuroscience Department; He graduated as a Medical Doctor from the University of Oran, Algeria; he then moved to Belgium, the City of Liege, for a Residency in Internal Medicine and Neurology at Liege University; after getting the Belgian Board of Neurology (with high marks), he went to the National Hospital for Nervous Diseases, Queen Square, London, United Kingdom for a fellowship in Clinical Neurophysiology, under Pr Willison ; Dr Mesraoua had also further training in Epilepsy and Continuous EEG Monitoring for two years (from 2001-2003) in the Neurophysiology department of Zurich University, Switzerland, under late Pr Hans Gregor Wieser ,an internationally known epileptologist expert. \n\nDr B. Mesraoua is the Director of the Neurology Fellowship Program at the Neurology Section and an active member of the newly created Comprehensive Epilepsy Program at Hamad General Hospital, Doha, Qatar; he is also Assistant Director of the Residency Program at the Qatar Medical School. \nDr B. Mesraoua's main interests are Epilepsy, Multiple Sclerosis, and Clinical Neurology; He is the Chairman and the Organizer of the well known Qatar Epilepsy Symposium, he is running yearly for the past 14 years and which is considered a landmark in the Gulf region; He has also started last year , together with other epileptologists from Qatar, the region and elsewhere, a yearly International Epilepsy School Course, which was attended by many neurologists from the Area.\n\nInternationally, Dr Mesraoua is an active and elected member of the Commission on Eastern Mediterranean Region (EMR ) , a regional branch of the International League Against Epilepsy (ILAE), where he represents the Middle East and North Africa(MENA ) and where he holds the position of chief of the Epilepsy Epidemiology Section; Dr Mesraoua is a member of the American Academy of Neurology, the Europeen Academy of Neurology and the American Epilepsy Society.\n\nDr Mesraoua's main objectives are to encourage frequent gathering of the epileptologists/neurologists from the MENA region and the rest of the world, promote Epilepsy Teaching in the MENA Region, and encourage multicenter studies involving neurologists and epileptologists in the MENA region, particularly epilepsy epidemiological studies. \n\nDr. Mesraoua is the recipient of two research Grants, as the Lead Principal Investigator (750.000 USD and 250.000 USD) from the Qatar National Research Fund (QNRF) and the Hamad Hospital Internal Research Grant (IRGC), on the following topics : “Continuous EEG Monitoring in the ICU “ and on “Alpha-lactoalbumin , proof of concept in the treatment of epilepsy” .Dr Mesraoua is a reviewer for the journal \"seizures\" (Europeen Epilepsy Journal ) as well as dove journals ; Dr Mesraoua is the author and co-author of many peer reviewed publications and four book chapters in the field of Epilepsy and Clinical Neurology",institutionString:"Weill Cornell Medical College in Qatar",institution:{name:"Weill Cornell Medical College in Qatar",country:{name:"Qatar"}}},{id:"282429",title:"Prof.",name:"Covanis",middleName:null,surname:"Athanasios",slug:"covanis-athanasios",fullName:"Covanis Athanasios",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/282429/images/system/282429.jpg",biography:null,institutionString:"Neurology-Neurophysiology Department of the Children Hospital Agia Sophia",institution:null},{id:"190980",title:"Prof.",name:"Marwa",middleName:null,surname:"Mahmoud Saleh",slug:"marwa-mahmoud-saleh",fullName:"Marwa Mahmoud Saleh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/190980/images/system/190980.jpg",biography:"Professor Marwa Mahmoud Saleh is a doctor of medicine and currently works in the unit of Phoniatrics, Department of Otolaryngology, Ain Shams University in Cairo, Egypt. She got her doctoral degree in 1991 and her doctoral thesis was accomplished in the University of Iowa, United States. Her publications covered a multitude of topics as videokymography, cochlear implants, stuttering, and dysphagia. She has lectured Egyptian phonology for many years. Her recent research interest is joint attention in autism.",institutionString:"Ain Shams University",institution:{name:"Ain Shams University",country:{name:"Egypt"}}},{id:"259190",title:"Dr.",name:"Syed Ali Raza",middleName:null,surname:"Naqvi",slug:"syed-ali-raza-naqvi",fullName:"Syed Ali Raza Naqvi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259190/images/system/259190.png",biography:"Dr. Naqvi is a radioanalytical chemist and is working as an associate professor of analytical chemistry in the Department of Chemistry, Government College University, Faisalabad, Pakistan. Advance separation techniques, nuclear analytical techniques and radiopharmaceutical analysis are the main courses that he is teaching to graduate and post-graduate students. In the research area, he is focusing on the development of organic- and biomolecule-based radiopharmaceuticals for diagnosis and therapy of infectious and cancerous diseases. Under the supervision of Dr. Naqvi, three students have completed their Ph.D. degrees and 41 students have completed their MS degrees. He has completed three research projects and is currently working on 2 projects entitled “Radiolabeling of fluoroquinolone derivatives for the diagnosis of deep-seated bacterial infections” and “Radiolabeled minigastrin peptides for diagnosis and therapy of NETs”. He has published about 100 research articles in international reputed journals and 7 book chapters. 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At the same time, they are faced with the Covid-19 pandemic leading to what some authors have called potential syndemics that might worsen the outcome of such infections. Therefore, it is important to conduct studies that examine parasitic infections in the context of the coronavirus pandemic for the benefit of all communities to help foster more informed decisions for the betterment of human and animal health.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/5.jpg",keywords:"Blood Borne Parasites, Intestinal Parasites, Protozoa, Helminths, Arthropods, Water Born Parasites, Epidemiology, Molecular Biology, Systematics, Genomics, Proteomics, Ecology"},{id:"6",title:"Viral Infectious Diseases",scope:"The Viral Infectious Diseases Book Series aims to provide a comprehensive overview of recent research trends and discoveries in various viral infectious diseases emerging around the globe. The emergence of any viral disease is hard to anticipate, which often contributes to death. A viral disease can be defined as an infectious disease that has recently appeared within a population or exists in nature with the rapid expansion of incident or geographic range. This series will focus on various crucial factors related to emerging viral infectious diseases, including epidemiology, pathogenesis, host immune response, clinical manifestations, diagnosis, treatment, and clinical recommendations for managing viral infectious diseases, highlighting the recent issues with future directions for effective therapeutic strategies.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/6.jpg",keywords:"Novel Viruses, Virus Transmission, Virus Evolution, Molecular Virology, Control and Prevention, Virus-host Interaction"}],annualVolumeBook:{},thematicCollection:[],selectedSeries:null,selectedSubseries:null},seriesLanding:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. This Biochemistry Series will address the current research on biomolecules and the emerging trends with great promise.",coverUrl:"https://cdn.intechopen.com/series/covers/11.jpg",latestPublicationDate:"May 15th, 2022",hasOnlineFirst:!0,numberOfOpenTopics:4,numberOfPublishedChapters:286,numberOfPublishedBooks:27,editor:{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},subseries:[{id:"14",title:"Cell and Molecular Biology",keywords:"Omics (Transcriptomics; Proteomics; Metabolomics), Molecular Biology, Cell Biology, Signal Transduction and Regulation, Cell Growth and Differentiation, Apoptosis, Necroptosis, Ferroptosis, Autophagy, Cell Cycle, Macromolecules and Complexes, Gene Expression",scope:"The Cell and Molecular Biology topic within the IntechOpen Biochemistry Series aims to rapidly publish contributions on all aspects of cell and molecular biology, including aspects related to biochemical and genetic research (not only in humans but all living beings). We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics include, but are not limited to: Advanced techniques of cellular and molecular biology (Molecular methodologies, imaging techniques, and bioinformatics); Biological activities at the molecular level; Biological processes of cell functions, cell division, senescence, maintenance, and cell death; Biomolecules interactions; Cancer; Cell biology; Chemical biology; Computational biology; Cytochemistry; Developmental biology; Disease mechanisms and therapeutics; DNA, and RNA metabolism; Gene functions, genetics, and genomics; Genetics; Immunology; Medical microbiology; Molecular biology; Molecular genetics; Molecular processes of cell and organelle dynamics; Neuroscience; Protein biosynthesis, degradation, and functions; Regulation of molecular interactions in a cell; Signalling networks and system biology; Structural biology; Virology and microbiology.",annualVolume:11410,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"79367",title:"Dr.",name:"Ana Isabel",middleName:null,surname:"Flores",fullName:"Ana Isabel Flores",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRpIOQA0/Profile_Picture_1632418099564",institutionString:null,institution:{name:"Hospital Universitario 12 De Octubre",institutionURL:null,country:{name:"Spain"}}},{id:"328234",title:"Ph.D.",name:"Christian",middleName:null,surname:"Palavecino",fullName:"Christian Palavecino",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000030DhEhQAK/Profile_Picture_1628835318625",institutionString:null,institution:{name:"Central University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"186585",title:"Dr.",name:"Francisco Javier",middleName:null,surname:"Martin-Romero",fullName:"Francisco Javier Martin-Romero",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSB3HQAW/Profile_Picture_1631258137641",institutionString:null,institution:{name:"University of Extremadura",institutionURL:null,country:{name:"Spain"}}}]},{id:"15",title:"Chemical Biology",keywords:"Phenolic Compounds, Essential Oils, Modification of Biomolecules, Glycobiology, Combinatorial Chemistry, Therapeutic peptides, Enzyme Inhibitors",scope:"Chemical biology spans the fields of chemistry and biology involving the application of biological and chemical molecules and techniques. In recent years, the application of chemistry to biological molecules has gained significant interest in medicinal and pharmacological studies. This topic will be devoted to understanding the interplay between biomolecules and chemical compounds, their structure and function, and their potential applications in related fields. Being a part of the biochemistry discipline, the ideas and concepts that have emerged from Chemical Biology have affected other related areas. This topic will closely deal with all emerging trends in this discipline.",annualVolume:11411,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null,editorialBoard:[{id:"241413",title:"Dr.",name:"Azhar",middleName:null,surname:"Rasul",fullName:"Azhar Rasul",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRT1oQAG/Profile_Picture_1635251978933",institutionString:null,institution:{name:"Government College University, Faisalabad",institutionURL:null,country:{name:"Pakistan"}}},{id:"178316",title:"Ph.D.",name:"Sergey",middleName:null,surname:"Sedykh",fullName:"Sergey Sedykh",profilePictureURL:"https://mts.intechopen.com/storage/users/178316/images/system/178316.jfif",institutionString:null,institution:{name:"Novosibirsk State University",institutionURL:null,country:{name:"Russia"}}}]},{id:"17",title:"Metabolism",keywords:"Biomolecules Metabolism, Energy Metabolism, Metabolic Pathways, Key Metabolic Enzymes, Metabolic Adaptation",scope:"Metabolism is frequently defined in biochemistry textbooks as the overall process that allows living systems to acquire and use the free energy they need for their vital functions or the chemical processes that occur within a living organism to maintain life. Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. Thus all studies on metabolism will be considered for publication.",annualVolume:11413,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",fullName:"Anca Pantea Stoian",profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"203824",title:"Dr.",name:"Attilio",middleName:null,surname:"Rigotti",fullName:"Attilio Rigotti",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institutionString:null,institution:{name:"Pontifical Catholic University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"300470",title:"Dr.",name:"Yanfei (Jacob)",middleName:null,surname:"Qi",fullName:"Yanfei (Jacob) Qi",profilePictureURL:"https://mts.intechopen.com/storage/users/300470/images/system/300470.jpg",institutionString:null,institution:{name:"Centenary Institute of Cancer Medicine and Cell Biology",institutionURL:null,country:{name:"Australia"}}}]},{id:"18",title:"Proteomics",keywords:"Mono- and Two-Dimensional Gel Electrophoresis (1-and 2-DE), Liquid Chromatography (LC), Mass Spectrometry/Tandem Mass Spectrometry (MS; MS/MS), Proteins",scope:"With the recognition that the human genome cannot provide answers to the etiology of a disorder, changes in the proteins expressed by a genome became a focus in research. Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. The Proteomics topic aims to attract contributions on all aspects of MS-based proteomics that, by pushing the boundaries of MS capabilities, may address biological problems that have not been resolved yet.",annualVolume:11414,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null,editorialBoard:[{id:"72288",title:"Dr.",name:"Arli Aditya",middleName:null,surname:"Parikesit",fullName:"Arli Aditya Parikesit",profilePictureURL:"https://mts.intechopen.com/storage/users/72288/images/system/72288.jpg",institutionString:null,institution:{name:"Indonesia International Institute for Life Sciences",institutionURL:null,country:{name:"Indonesia"}}},{id:"40928",title:"Dr.",name:"Cesar",middleName:null,surname:"Lopez-Camarillo",fullName:"Cesar Lopez-Camarillo",profilePictureURL:"https://mts.intechopen.com/storage/users/40928/images/3884_n.png",institutionString:null,institution:{name:"Universidad Autónoma de la Ciudad de México",institutionURL:null,country:{name:"Mexico"}}},{id:"81926",title:"Dr.",name:"Shymaa",middleName:null,surname:"Enany",fullName:"Shymaa Enany",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRqB9QAK/Profile_Picture_1626163237970",institutionString:null,institution:{name:"Suez Canal University",institutionURL:null,country:{name:"Egypt"}}}]}]}},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"chapter.detail",path:"/chapters/17226",hash:"",query:{},params:{id:"17226"},fullPath:"/chapters/17226",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()