Main sources of water supplied and main water consumers in Israel 2000-2007 (Sources: Israel Central Bureau of Statistics, 2008; Water Authority).
\r\n\tThus, we call for research and review papers on the chemistry and physics of dyes, pigments, and their intermediates, including chemical constituents, spectroscopic aspects, surface, solution, crystal formation, photochemical, and ecological or biological properties. The book will be of interest to a wide variety of researchers worldwide whose work involves various fields of activity such as dyes and pigment synthesis, imaging, sensor, energy, medicine, polymers, food product, toxicological properties, etc.
",isbn:"978-1-83768-114-3",printIsbn:"978-1-83768-113-6",pdfIsbn:"978-1-83768-115-0",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!1,isSalesforceBook:!1,isNomenclature:!1,hash:"fcd069956c2e931195925b19a74ce9a3",bookSignature:"Dr. Brajesh Kumar",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/12081.jpg",keywords:"Heterocycles Pigments, Azo, Nitro, Indigo, Alizarin, Chromophores, Chromophores, Photochemical, Sulphonation, Diazotisation, UV-Vis Spectroscopy, Metal-Ligand",numberOfDownloads:15,numberOfWosCitations:0,numberOfCrossrefCitations:0,numberOfDimensionsCitations:0,numberOfTotalCitations:0,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"May 19th 2022",dateEndSecondStepPublish:"June 16th 2022",dateEndThirdStepPublish:"August 15th 2022",dateEndFourthStepPublish:"November 3rd 2022",dateEndFifthStepPublish:"January 2nd 2023",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"2 months",secondStepPassed:!0,areRegistrationsClosed:!0,currentStepOfPublishingProcess:4,editedByType:null,kuFlag:!1,biosketch:"Dr. Brajesh Kumar has worked as a faculty member in various universities in India, Ecuador, and South Korea. He has published numerous SCI/SCIE/Scopus research articles and is an active reviewer of more than 50 Journals. Dr. Kumar is a member of the American Chemical Society, the Indian Society of Chemists and Biologists, and the Indian Science Congress Association and holder of two registered patents. He is included in the top 2% of the scientist list prepared by experts at Stanford University,",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"176093",title:"Dr.",name:"Brajesh",middleName:null,surname:"Kumar",slug:"brajesh-kumar",fullName:"Brajesh Kumar",profilePictureURL:"https://mts.intechopen.com/storage/users/176093/images/system/176093.JPG",biography:"Dr. Brajesh Kumar is currently working as an Assistant Professor and Head in the Post Graduate Department of Chemistry, TATA College, Chaibasa, India. He received a Ph.D. in Chemistry from the University of Delhi, India. His research interest is in the development of sustainable and eco-friendly techniques for (a) nanoparticles synthesis and their applications for environmental remediation, (b) active films of organic solar cells, (c) nanomedicine, (d) sensors, (e) natural product extraction, purification, and analysis,(f) natural polymers, (g) peptide chemistry, (h) microwave and ultrasound-assisted organic synthesis and (i) organic synthesis. Dr. Brajesh Kumar has been credited for different national and international fellowships and he has also worked as a faculty member in various universities of India, Ecuador, and South Korea. He has also published numerous SCI/ SCIE/ Scopus research articles (h index = 29, Citations 2917) and is also an active reviewer of more than 50 Journals. 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From chapter submission and review to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact."}},relatedBooks:[{type:"book",id:"10469",title:"Nanofibers",subtitle:"Synthesis, Properties and Applications",isOpenForSubmission:!1,hash:"28dc655dde01b94399cab954663f8bff",slug:"nanofibers-synthesis-properties-and-applications",bookSignature:"Brajesh Kumar",coverURL:"https://cdn.intechopen.com/books/images_new/10469.jpg",editedByType:"Edited by",editors:[{id:"176093",title:"Dr.",name:"Brajesh",surname:"Kumar",slug:"brajesh-kumar",fullName:"Brajesh Kumar"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10489",title:"Biocomposites",subtitle:null,isOpenForSubmission:!1,hash:"c794533fcae9dcea38672f814ae182db",slug:"biocomposites",bookSignature:"Brajesh Kumar",coverURL:"https://cdn.intechopen.com/books/images_new/10489.jpg",editedByType:"Edited by",editors:[{id:"176093",title:"Dr.",name:"Brajesh",surname:"Kumar",slug:"brajesh-kumar",fullName:"Brajesh Kumar"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. 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Without them, human society would be unable to prosper or even exist. The ever-growing conflicting demands for fresh water supplies threaten the sustainability of this essential resource. Decreasing usable water supplies, coupled with rapid increases in demand and poor management, have led to the inefficient and unsustainable use of water resources with significant economic, social, and environmental ramifications. The failure to meet basic human and environmental needs for water has given rise to increasing tensions over access to water. Many believe that the competition over scarce water resources, which regularly occurs at local, regional, and international scales, will increase tensions and possibly cause armed conflicts between states and sectors (see for example Clarke 1991, Gleick 1993, 2000, Postel 1997, Duba and El-Ashry 2000).
\n\t\t\tIn the current work, the use of risk management methodology is suggested to increase the flexibility and security of agreements over the management of water resources. This methodology has a long history of experience in the field of project management. It has its roots in the understanding that risk events without preplanned responses have the potential to cause irreversible damage to projects. The experience, gained through managing risks related to commercial projects, has greatly contributed to the applicability of risk management theory. Therefore, it is an adequate tool, which can help improve water resource management by mitigating risks involved in its maintenance and utilization.
\n\t\t\tIn this paper, the risk management methodology is adopted to increase flexibility, which is necessary for the efficient management of water resources. Since the nature of this resource predetermines that many of the risks associated with it are not easily controlled, we suggest a modification of the standard risk management methodology by accounting for an inability to control a given risk at an early planning stage. Thus, the controllability of the risk is incorporated among the risk identification parameters, in order to avoid dealing with natural risks that are
The paper is organized as follows: Chapter 2 discusses some aspects and considerations associated with managing a water resource, the natural and social constraints that may affect both the risks associated with the resource and the possible treatments for these risks. Chapter 3 presents some basics of the risk management methodology, and introduces the concept of risk controllability, which is important for addressing risks in an efficient manner. In Chapter 4, an empirical study of risk analysis is carried out regarding Israeli water resources, followed by Chapter 5’s concluding remarks.
\n\t\tWater resource management can be broadly defined by two large and, at times, conflicting, systems:
Water is perceived as the basis of all life. Civilizations, from ancient times up to the present, have maintained complex relationships with water. Balancing often contradicting needs to supply for soil cultivation, natural habitats, and industrial and human needs; the approach to water resource management alternates between the materialized approach of industrialized societies, which perceives water largely as another raw material input for commodity production in agriculture and industry, to the idyllic conceptualization of water as a sacred source of life, thus maintaining its nonuse value.
\n\t\t\t\tFrom the natural system perspective, water plays an ecological role, as it flows across land, from the land into the sea, from the sea into the atmosphere, and from the atmosphere back to the land. Management that focuses on water merely as a resource to be tapped and distributed has harmful effects on its conflicting uses in the hydrological cycle and the replenishment of watersheds. On the other hand, a water resource management perspective that views water as a resource to be consumed, rather than a natural flow in the water cycle, generates the misconception that water resources can be continually augmented through large man-made structures.
\n\t\t\t\tThe ecological understanding of water involves two factors: firstly, an understanding of the relationship between water and other elements in the ecosystem; and secondly, an understanding of the limits of water use, which must be enforced by the preservation of the water cycle. A mare bias that favors water development fails to perceive the natural river flows as being critical for drainage purposes, recharging of groundwater, and maintaining the balance between fresh water and seawater.
\n\t\t\t\tThe impounding of water in large dams leads to deforestation in the catchment areas, changes in the micro-climate, as well as soil erosion, thus decreasing the availability of water, and in some cases leading to floods. The transport of large volumes of water over long distances for agricultural and household use results in water wastage through seepage. The introduction of large volumes of water beyond the natural drainage capacity of the ecosystem disrupts the hydrological cycle and results in water logging and salinity.
\n\t\t\tThe natural perspective is only one side of water resource management. The other side is the perspective of the human society that utilizes the resource for its livelihood. Considering the social values, beliefs and arrangements involved in the utilization of any fresh water resource significantly expands potential adaptation strategies with implications for meeting agreed-upon future goals. Many adaptation challenges are due to social constraints, and are restricted to the social ability to employ different means of adaptation over time, at different stages of conflicts, and in response to different perceptions of what constitutes the challenges that must be met.
\n\t\t\t\tViewed from this perspective, the evolution of water management practices involves responding to social conflicts over perceived risks by identifying bottlenecks, and finding appropriate tools to meet the challenges posed. As policy makers seek different adaptation strategies, they often experience a perceived scarcity in the social means required to initiate policies for watershed management. Social tools are needed, so that the necessary policies required to control water crises are transformed into a driving force that can actively initiate changes in social perspective and power distribution. Managing this process involves learning how to deal with different types of conflicts - conflicts encountered as a result of the natural resource scarcity itself, as well as conflicts encountered as a result of inadequate strategies adopted to treat water demands and needs.
\n\t\t\t\tHowever, the social perspective is not only about the needs related to the water resource. It is also the perspective of social power related to the utilization of such a resource. Social frictions over resource scarcity impede the supply of social ingenuity, particularly as regards the formation of new and reformed institutions, and contribute to the formation of social coalitions that oppose change (Homer-Dixon, 1995 and Olson, 1982). These coalitions often operate across multiple scales and may disrupt cooperation solutions for the commonwealth, as they pursue their own self interests. Thus, there may be an increase in conflicting interests among those involved in the physical management of water. This type of involvement can prevent efficient problem-solving and increase the turmoil in local management bureaucracy; which in turn, could prevent effective management procedures at the local level.
\n\t\t\t\tA growing body of literature shows how narrow, interest-based coalitions obstruct sustainable economic development and effective social adaptation to resource scarcity (Olson, 1982, Reed, 1992,Ostrom, Schroeder, and Wynne 1993, Ruttan, 1989). As water contamination and scarcity increase, and acceptable social adaptations fail to materialize, competition over water usage begins to develop among interest groups. As these narrow, interest-based coalitions pursue their own private interests, they often hinder the creation and implementation of broad-scale welfare programs aimed at improving institutional solutions for water resource problems.
\n\t\t\t\tMancur Olson’s (Olson 1982) work on the ability of different types of social coalitions to provide collective goods for their members offers critical insight into the nature of these coalitions. First, small groups generally organize more quickly and exert their interests more vigorously than larger groups. This provides small groups with greater relative political power and allows them to be more efficient in their lobbying efforts (e.g. flexible, focused and effective). Second, the ability to yield disproportionate power, relative to size, is especially evident in “unstable” societies (a phenomena which characterizes most poor nations) because larger coalitions take time and social stability to grow and mature. As a result, Olson argues that governments of unstable nation-states are “systematically influenced by the interests, pleas and pressures” of small coalitions (Olson, 1982, Homer-Dixon, 1995). Third, and perhaps most importantly, small coalitions tend to pursue their own narrow self-interests, rather than the broader social interest; hence, their actions often hinder the establishment of institutions that might serve to benefit society at large. Because of this, narrow coalitions tend to be characterized as “distributional”, in that they seek to redistribute wealth rather than create it.
\n\t\t\t\tNarrow interest-based coalitions clearly have the potential to intensify existing conflicts and complicate any risk management processes. The increasing participation of new actors in water policy and management decisions at all social scales (local, regional, national, transnational) will likely make it much easier for these narrow coalitions (at all social scales) to advance their interests in the risk management arena.
\n\t\t\t\tHistorically, social adaptations to water scarcity were determined and implemented by centralized government agencies. Until recently, donors presumed sovereignty of national governments by working with national legislatures on water issues and by providing economic assistance at the national level. Nation-states were perceived as sole sovereign powers and the sole potential recipients of donor aid for water investments (Ostrom, 1992). This increased and consolidated the power of central authorities over local authorities and the population in general.
\n\t\t\t\tThis view has changed significantly. In the past decade, there has been an increased participation of new actors in water policy and management decisions at all social scales (local, regional, national, transnational). This increased participation is the result of two factors. The first is an increased internal restlessness with the performance of central governments by local communities. This restlessness arises in response to the choice of the central government to ignore local needs of certain populations. This practice of the central government may be rooted in its inability to collect needed information that is accessible to local population, or in its insensitivity to the needs and interests of communities located away from influencing power.
\n\t\t\t\tThus, an increase in public participation also plays the role of voicing interests that were previously unheard under central government management of a water resource. An increase in public participation also results from the central government\'s choice to ignore local interests. So, from both aspects, an increase in public participation strengthens management efficiency and enhances social welfare. This, in turn, augments social adaptive capacity with regard to the water resource. An awareness of the needs that were ignored enables a central government to suggest compensation and other means of livelihood. In addition, this awareness also helps to decrease the social restlessness of population segments that may have felt deprived of their fair share in public goods offered by the state.
\n\t\t\tRisks associated with water may be augmented by complex legal situations that tie water rights to other aspects of property rights. One reason that a government may want to keep water-augmented occupations concerns legal land water attachments. The most obvious example is that of the total rejection of any water use agreement between Israel and the Palestinian Authority. Narrowly considering the water dispute between Israel and the Palestinians suggests that, since the water conflict between these two entities is actually a moderate income dispute (e.g., Zeitouni et al. 1994; Becker and Zeitouni, 1998), one entity should be able to compensate the other for shifting part of its agricultural sector to other fields of employment, thus preserving the income generation interests of this sector by way of a simple money transfer. As true as the economic concept of compensation may be, failing to acknowledge the fact that the legal link between plowing the land and its ownership that is originated back in the Ottoman era, led to under-representation of the opportunity cost of water as agricultural input. Under different legal ties between water and land ownership, the opportunity cost of giving away water may have been smaller.
\n\t\t\tReducing possible damage from water - associated risks may first and for most come from reducing unnecessary excessive use of water. This ability depends at large on the ability of societies and individuals within societies to adopt more efficient usage patterns. However, the opportunity cost of giving up part of the water from the very same river basin may vary widely between countries of different technological and economic adaptability.
\n\t\t\t\tThe reason for this is the different capability of nations regarding changes in employment opportunities. Nations with a social structure that allows for relatively easy mobility from water augmented occupations and livelihood into other occupations or employment opportunities incur smaller social costs for restructuring their use of water resources. Social stability is gained by using the water resource as a low-cost means to support employment in traditional ways, mainly through agriculture production. The cost of the water input may be lower to the user nation since, in the absence of agreed-upon international allocation, a bordering water body country can exploit the common pool’s externality of this resource. This external benefit enables the bordering nation to ignore the actual real cost of the water.
\n\t\t\t\tIn the short run, inefficient utilization of a water resource allows at least some of the involved parties to enjoy the external benefit, at the expense of other parties involved in this dispute. For these parties, these external benefits increase the cost of resolving the dispute.
\n\t\t\t\tIndustrialization and economic development may ease the pressure on water use as a primary input by providing the necessary (but not sufficient) augmentation of employment opportunities. Thus, in the modern arena, any discussion of risk adaptation must first acknowledge the notion that a possible course of action is not necessarily about matters of life and death for individuals (i.e., thirst), but rather a matter of social inflexibility that needs to be addressed in order to reduce the social opportunity costs of resolving the water conflict.
\n\t\t\tSurface water and groundwater that cross international boundaries present significant challenges to regional stability because hydrologic needs can often be overwhelmed by political considerations. There are 261 rivers (Hammer, 1998) around the world, which cross the boundaries of two or more nations, and a large number of international groundwater aquifers. The basin areas that contribute to these rivers comprise approximately 47% of the earth’s land surface, and 40% of the world’s population, contributing to almost 60% of the freshwater flow (Wolf et al. 1999). With the continuous growth of world population and the diminishing water quality and quantity, water scarcity is increasing. As access to water is essential to the prosperity of communities, the threat of conflict over the use of transboundary water is also on the rise.
\n\t\t\t\tDisputes over water seldom accelerate into an armed conflict. However, there are quite a few examples where water disputes have evolved into a real threat to such an open conflict. While many believe that water may be a source or cause of conflicts (Samson and Charrier, 1997, Butts, 1997, Homer Dixon, 1994, Toset and Gleditsch, 2000), others are convinced there is strong evidence that nations are willing to find cooperative solutions for the use of transboundary water (Wolf, 1998, Salman and de Chazournes, 1998, Turton, 2000).
\n\t\t\t\tIn most cases, there are usually certain understandings and statutes that are maintained over time, even in the absence of an official agreement. However, often as a result of an absence in flexibility regarding the implementation of the agreement, the involved parties try, from time to time, to change the statutes. Some examples of this phenomenon presented themselves in the case of the Jordan River basin, where several incidents occurred in which Syria and Lebanon tried to divert the sources of the Jordan River. These incidents finally culminated in an extended period of tension, which continued to mount, almost leading to an armed conflict. This example indicates that, whenever possible, a flexible agreement should be clearly defined, and the penalties for each deviation should be clearly spelled out to all sides.
\n\t\t\t\tLowi (1995) discusses several agreements concerning the water allocation of the Jordan River and the Euphrates. In both cases, there is no official agreement for sharing the water and the resource is managed by some form of cooperation in order to meet the nations’ needs. Lowi (1995) addresses ways in which to improve the development and management of water-related international disputes without pre-agreed upon guidelines or rules regarding the management of conflicts among the nations involved.
\n\t\t\t\n\t\t\t\t
It is only a natural extension, then, to apply this methodology to the field of resource management, as was presented by Gonen and Zeitouni (Gonen and Zeitouni 2008) for the case of transboundary water resources. The difference between managing private projects and managing public resources lies in the nature of some of the risks, their evaluation, and the strategies that are available for mitigating them.
\n\t\t\tIn general, threats are identified and then assessed according to their likelihood or probability to occur, and their realized conditional damage functions. Thus, expected damage is calculated as a reference measure in the decision about proper action. This approach enables the estimation of a risk budget when there is more than one risk. However, it is not very suitable for water resource management, since some of the damages are difficult to estimate, and the probability of their occurrence is even more complicated to estimate. In addition, the question of risk controllability is not readily answered. Most natural risks cannot be controlled; therefore, the possibility to propose a response plan is limited. In order to handle these types of risks, we suggest quantifying risks into three dimensions, instead of the two that are used today. The third dimension, which is introduced below for the measured risk, relates to its controllability. The
In order to formulate this idea mathematically, let Ω be the set of all possible relevant risk events, Ω={α/ α is a risk event}. Let the damage function, D, be a function from Ω to R+, which satisfies the condition" that if
Then, for a given probability measure P that is defined on Ω, the expected damage
Methods to attach a monetary value to the damage function may vary. It is, however, important to note that research has shown that the results of the use of valuation techniques can depend not only on the probability of an event’s occurrence, but also on the incorporation of the valued socio-economic effects into the decision making process. A Risk Assessment approach takes both dimensions into account.
\n\t\t\t\tA very small probability of occurrence reduces the appropriateness of several valuation techniques. For example, land market traders appear unable to incorporate flood potential without some major flood to anchor their perceptions to. Hedonic estimates are sensitive to the market traders’ recent experience with a natural hazard. Hedonic estimates are either very large or zero, depending on the timing of the study vis-à-vis the latest flood (Shabman and Stephenson [1996]). Bartosova et al. [1999] show that when using the Hedonic Price Method, the detrimental effect of flood risk is eliminated after the expected flood risk falls to once every 33.33 years. Daun et al. [Daun et al. 2000] confirmed the hypothesis that a household’s WTP for the maintenance of current levels of flood risk is positively related to flood risks as proxied by the household’s distance from the river.
\n\t\t\t\t\tIt can be concluded that the choice of valuation techniques determines, to some extent, the weight given to prescribed risks. The results of some techniques (such as Replacement/ Substitute costs) are unaffected by the probabilities itself. In contrast, other techniques (like the Hedonic Price Method) are highly affected by the probabilities.
\n\t\t\t\tThe application of a valuation technique is only one issue that determines the way given threats are dealt with. Other characteristics of the decision making process may affect the assessment as well. Among them are: accounting for all possible damages, monetarizing them, selection and use of valuation methods, use of discount rate, accountability for non-monetary values, presence of limiting conditions, and the risk attitude of decision-makers.
\n\t\t\t\t\tWhen weighing up the costs and benefits of a decision regarding management of a given risk, the result will strongly depend on the effects that are taken into account. The choice between social or private costs and benefits will be largely determined by the social responsibility valuators take. The choice of effects to be monetarized will also be influenced by their risk attitude.
\n\t\t\t\t\tThe outcome of the use of a valuation technique is often used to calculate present values in the context of the damage function. This implies that weights are attached to effects of the specific risk in the future. Defining the appropriate discount rate is not straightforward and no firm conclusions can be drawn about which rate should be used. Economic theory does not impose a certain rate on the decision-maker; it is, rather, the opinion of the decision-maker himself within his institutional context that determines the rate.
\n\t\t\t\t\tThe extent to which non-monetary effects are taken into account in the calculation of the damage function will also have its implications on how society deals with the risk. Limiting conditions can have an effect on both probabilities and possible damage. The timing when the assessment is carried out may be crucial in determining whether a given condition is limiting or not. For example, the consideration of a flood risk may lead to different recommendations regarding the risk handling, if it relates to the question of whether or not to go on with a housing project that is being built on a river bank, than when it relates to possible flood control after houses are already standing on the same river bank. Moreover, the attitude towards handling uncertainties regarding the outcome of each step in the process of damage function valuation (starting with the identification and selection of effects up to the application of valuation methods) may strongly steer if and how the valuation takes place.
\n\t\t\t\tThe sole consideration of expected damage is insufficient in the management of water resources, since not only are the damages and their respected probabilities difficult to estimate, but most natural risks cannot be controlled; therefore, the possibility to propose a response plan may be very limited. In order to handle these types of risks, it is suggested to define any given
For each risk event
D(α/β) is the damage that may occur if risk α is realized, given that response β was applied. Let us define the social utility from response β as:
\n\t\t\t\tUβ measures the difference between the expected cost without response β and the expected cost with it. If a response β is selected, its cost is Cβ and the expected damage changes to: P(α/β)*D(α/β). Therefore, if Uβ is positive for a given response β, then the response lowers the expected damage sufficiently to offset the cost of the response. If Uβ is negative, then the given response is too costly, relative to its effect on the expected damage. If for every possible response plan β - Uβ is negative, then the risk α is said to be uncontrollable.
\n\t\t\t\tA positive U is necessary for a risk to be controllable, but it is often not sufficient. A risk α may have a profitable response plan, but the policy maker does not have an available budget that can be allocated for it. The set of all responses to risk α is: Rα ={β/ β is a response plan to event α}. The controllability measure is:
\n\t\t\t\tThus, a positive B indicates the capability of mitigating risk α.
\n\t\t\t\tThe following numerical example illustrates the use of the controllability concept. Consider the possibility of terrorists poisoning water resources over the next 10 years. The probability of such an event would depend on the country in which the resource is located, its enemies, its political situation, and the like. Let us assume that this probability is 0.01 % or Pα=0.0001. The realized damage depends on the type of poisoning, the capability to detect this poisoning, and the size of the water resource. Let us assume that there are no detection sensors and that the poisoning level is highly severe. Thus, the damage is estimated to be $10,000M. In this case, the expected value of the damage, E(D()), would be $1,000,000.
\n\t\t\t\tThere is a response plan β that includes installing a detection system for the cost of $0.5 M (Cβ=500,000), which has a 90% chance of detecting such an event. If this detection system is introduced, the expected damage would only be $100 M. Thus, the detection system indicates a conditional probability of damage, P(α/β)=Pα*0.1=10-410-1 = 10-5 and the value of the conditional damage function, D(α/β)=108. Hence, the social utility from this particular response is equal to:
\n\t\t\t\tUβ=1,000,000 – (500,000 + 10810-5) = 499,000.
\n\t\t\t\tSince Uβ>0, we say that the risk is controllable.
\n\t\t\tIsrael’s water resources include the Sea of Galilee, some streams, three main underground aquifers, a few dams, and rain water that seeps into the underground aquifers or is pooled into above-ground reservoirs. In addition, the country exploits a considerable amount of effluents, sewage water that is cleaned and filtered by undergoing various types of treatments and water desalination. Table 1 presents the amount of water produced and consumed in Israel between 2000 and 2007.
\n\t\t\t\t\n\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\t\t
WATER PRODUCTION AND CONSUMPTION (millions of cubic meters) | \n\t\t\t\t\t\t||||
PRODUCTION | \n\t\t\t\t\t\t\t*2007 | \n\t\t\t\t\t\t\t2006 | \n\t\t\t\t\t\t\t2005 | \n\t\t\t\t\t\t\t2000 | \n\t\t\t\t\t\t
BY PRODUCER(2) | \n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t | \n\t\t\t\t\t\t |
TOTAL | \n\t\t\t\t\t\t\t2,199 | \n\t\t\t\t\t\t\t1,996 | \n\t\t\t\t\t\t\t2,063 | \n\t\t\t\t\t\t\t1,996 | \n\t\t\t\t\t\t
Mekorot Water Co.- total \n\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t1,394 | \n\t\t\t\t\t\t\t1,330 | \n\t\t\t\t\t\t\t1,379 | \n\t\t\t\t\t\t\t1,341 | \n\t\t\t\t\t\t
Wells (3) | \n\t\t\t\t\t\t\t747 | \n\t\t\t\t\t\t\t670 | \n\t\t\t\t\t\t\t564 | \n\t\t\t\t\t\t\t725 | \n\t\t\t\t\t\t
Hamovil water carrier (Kinneret) | \n\t\t\t\t\t\t\t224 | \n\t\t\t\t\t\t\t242 | \n\t\t\t\t\t\t\t401 | \n\t\t\t\t\t\t\t230 | \n\t\t\t\t\t\t
Upper water | \n\t\t\t\t\t\t\t194 | \n\t\t\t\t\t\t\t201 | \n\t\t\t\t\t\t\t211 | \n\t\t\t\t\t\t\t216 | \n\t\t\t\t\t\t
Effluents (4) | \n\t\t\t\t\t\t\t229 | \n\t\t\t\t\t\t\t217 | \n\t\t\t\t\t\t\t203 | \n\t\t\t\t\t\t\t170 | \n\t\t\t\t\t\t
Other producers - total | \n\t\t\t\t\t\t\t682 | \n\t\t\t\t\t\t\t666 | \n\t\t\t\t\t\t\t684 | \n\t\t\t\t\t\t\t655 | \n\t\t\t\t\t\t
Wells | \n\t\t\t\t\t\t\t317 | \n\t\t\t\t\t\t\t316 | \n\t\t\t\t\t\t\t319 | \n\t\t\t\t\t\t\t331 | \n\t\t\t\t\t\t
Upper water | \n\t\t\t\t\t\t\t207 | \n\t\t\t\t\t\t\t208 | \n\t\t\t\t\t\t\t233 | \n\t\t\t\t\t\t\t225 | \n\t\t\t\t\t\t
Effluents | \n\t\t\t\t\t\t\t158 | \n\t\t\t\t\t\t\t142 | \n\t\t\t\t\t\t\t132 | \n\t\t\t\t\t\t\t99 | \n\t\t\t\t\t\t
CONSUMPTION | \n\t\t\t\t\t\t\t\n\t\t\t\t\t\t | |||
BY CONSUMER AND SUPPLIER(2) | \n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t | \n\t\t\t\t\t\t |
TOTAL | \n\t\t\t\t\t\t\t2,072 | \n\t\t\t\t\t\t\t1,959 | \n\t\t\t\t\t\t\t1,961 | \n\t\t\t\t\t\t\t1,924 | \n\t\t\t\t\t\t
Mekorot Water Co. | \n\t\t\t\t\t\t\t1,418 | \n\t\t\t\t\t\t\t1,333 | \n\t\t\t\t\t\t\t1,303 | \n\t\t\t\t\t\t\t1,269 | \n\t\t\t\t\t\t
Other suppliers (5) | \n\t\t\t\t\t\t\t654 | \n\t\t\t\t\t\t\t626 | \n\t\t\t\t\t\t\t658 | \n\t\t\t\t\t\t\t655 | \n\t\t\t\t\t\t
Agricultural | \n\t\t\t\t\t\t\t1,186 | \n\t\t\t\t\t\t\t1,108 | \n\t\t\t\t\t\t\t1,126 | \n\t\t\t\t\t\t\t1,138 | \n\t\t\t\t\t\t
Mekorot Water Co. | \n\t\t\t\t\t\t\t700 | \n\t\t\t\t\t\t\t662 | \n\t\t\t\t\t\t\t655 | \n\t\t\t\t\t\t\t667 | \n\t\t\t\t\t\t
Other suppliers | \n\t\t\t\t\t\t\t486 | \n\t\t\t\t\t\t\t446 | \n\t\t\t\t\t\t\t471 | \n\t\t\t\t\t\t\t471 | \n\t\t\t\t\t\t
Domestic and public | \n\t\t\t\t\t\t\t767 | \n\t\t\t\t\t\t\t737 | \n\t\t\t\t\t\t\t715 | \n\t\t\t\t\t\t\t662 | \n\t\t\t\t\t\t
Mekorot Water Co. | \n\t\t\t\t\t\t\t639 | \n\t\t\t\t\t\t\t596 | \n\t\t\t\t\t\t\t571 | \n\t\t\t\t\t\t\t519 | \n\t\t\t\t\t\t
Other suppliers | \n\t\t\t\t\t\t\t128 | \n\t\t\t\t\t\t\t141 | \n\t\t\t\t\t\t\t144 | \n\t\t\t\t\t\t\t143 | \n\t\t\t\t\t\t
Industrial | \n\t\t\t\t\t\t\t119 | \n\t\t\t\t\t\t\t114 | \n\t\t\t\t\t\t\t120 | \n\t\t\t\t\t\t\t124 | \n\t\t\t\t\t\t
Mekorot Water Co. | \n\t\t\t\t\t\t\t79 | \n\t\t\t\t\t\t\t75 | \n\t\t\t\t\t\t\t77 | \n\t\t\t\t\t\t\t83 | \n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t | 40 | \n\t\t\t\t\t\t\t39 | \n\t\t\t\t\t\t\t43 | \n\t\t\t\t\t\t\t41 | \n\t\t\t\t\t\t
Main sources of water supplied and main water consumers in Israel 2000-2007 (Sources: Israel Central Bureau of Statistics, 2008; Water Authority).
\n\t\t\t\t\t
Part of the sewage that reaches the aquifer is not treated at all or only undergoes preliminary treatment before it enters the streams and sea. In addition, in many areas throughout the country, water lines are laid next to sewage pipes, thus causing leakages to the water system due to poor maintenance. A balance forecast of water in Israel, conducted by the World Bank in 1994, indicates an annual cumulative gap of 1 billion cubic meters by 2020.
\n\t\t\t\t\n\t\t\t\t\t
Another conflict for which there has been no solution as of yet concerns Israeli control of the West Bank aquifers since 1967. The 1967 nationalization of all the West Bank water resources by Israel increased the already existing tension over land issues between the Palestinians and Israelis.
\n\t\t\t\tIn the other part of the Palestinian Authority, Gaza, the quality of water in the groundwater aquifer is very low due to severe over-pumping. The coastal aquifer in this area has been almost completely destroyed; most of the damage is on the Palestinian side. Israelis and Palestinians will have to share water from the mountain aquifer, where there is a serious danger of salting, due to over-pumping and the use of untreated water for irrigation by the Palestinians. Israel controls and allows extraction of the Palestinian Authority over the mountain aquifer, according to the modification made in the Johnston Agreement to address water allocation to the Palestinian Authority.
\n\t\t\t\t\n\t\t\t\t\t
The last inclusive master plan for managing water resources was prepared in 1988. This plan included proposed sizes of desalination facilities, regardless of some contradicting economic considerations. The implementation of the plan was at most partial. Several rainy years and the high cost of implementation caused the government to postpone large parts of the plan; in particular, construction of several desalination facilities as the condition for establishing the desalination facilities was a government commitment to purchase large quantities of desalinated water, which is currently considered by the government to be too costly and inefficient.
\n\t\t\t\tAnother responsibility of the water authority is the security of the water supply. Among the security issues, terrorism is ranked as one of the eminent risk factors. The Water Authority makes a fairly big and successful effort to secure water facilities and diminish the likelihood of damage from any possible terrorist attack. There is also a backup and repair plan, in the event of any possible damage to the water facility. An automatic monitoring system, which operates throughout the national water carrier and in most existing reservoirs, is designed to detect any possible damage. In addition, natural sensors, such as fish and bacteria, are placed at important intersections and are monitored constantly to detect any possible change in their reaction to the environment.
\n\t\t\tThe first step in risk management is the identification of possible risks. This task requires information from experts in the field. For this study, interviews with experts in various fields related to water management in Israel were conducted, in order to identify the specific risks that are relevant to Israel. The major identified risks are presented in Table 2.
\n\t\t\t\t\n\t\t\t\t\t\t\t | Risk | \n\t\t\t\t\t\t\tDescription | \n\t\t\t\t\t\t\tCategory | \n\t\t\t\t\t\t
1 | \n\t\t\t\t\t\t\tDrought | \n\t\t\t\t\t\t\tSequence of dry years with low precipitation | \n\t\t\t\t\t\t\tNatural causes | \n\t\t\t\t\t\t
2 | \n\t\t\t\t\t\t\tEarthquakes | \n\t\t\t\t\t\t\tPowerful earthquakes that severely damage the water and sewage systems | \n\t\t\t\t\t\t\tNatural causes | \n\t\t\t\t\t\t
3 | \n\t\t\t\t\t\t\tLocal Terrorism - Sabotage | \n\t\t\t\t\t\t\tDamaging/destroying the pumping facilities or major pipe lines | \n\t\t\t\t\t\t\tWater Security | \n\t\t\t\t\t\t
4 | \n\t\t\t\t\t\t\tLocal terrorism - Poisoning | \n\t\t\t\t\t\t\tPoisoning reservoirs | \n\t\t\t\t\t\t\tWater Security | \n\t\t\t\t\t\t
5 | \n\t\t\t\t\t\t\tReservoir evaporation | \n\t\t\t\t\t\t\tIncrease in temperature, causing a rapid evaporation of exposed water reservoirs | \n\t\t\t\t\t\t\tNatural causes | \n\t\t\t\t\t\t
6 | \n\t\t\t\t\t\t\tAgricultural pollution | \n\t\t\t\t\t\t\tSeepage of chemicals and fertilizers into groundwater | \n\t\t\t\t\t\t\tManagement policy | \n\t\t\t\t\t\t
7 | \n\t\t\t\t\t\t\tPreventing water seepage | \n\t\t\t\t\t\t\tConstruction and development prevent water seepage into the aquifers | \n\t\t\t\t\t\t\tManagement policy | \n\t\t\t\t\t\t
8 | \n\t\t\t\t\t\t\tDiversion of transboundary water resources | \n\t\t\t\t\t\t\tDiverting transboundary water resources without an agreement can cause confrontations that might end in war | \n\t\t\t\t\t\t\tGeopolitics | \n\t\t\t\t\t\t
9 | \n\t\t\t\t\t\t\tClimate changes | \n\t\t\t\t\t\t\tClimate changes can raise the sea level and cause the transfer of seawater into the coastal aquifer. It can change the rain distribution and the rainy season. | \n\t\t\t\t\t\t\tNatural causes | \n\t\t\t\t\t\t
10 | \n\t\t\t\t\t\t\tChanges in the distribution of rain | \n\t\t\t\t\t\t\tChanges in the rain distribution that cause more rainy days and extreme floods | \n\t\t\t\t\t\t\tNatural causes | \n\t\t\t\t\t\t
11 | \n\t\t\t\t\t\t\tOver-pumping the mountain aquifer | \n\t\t\t\t\t\t\tLack of coordination in water usage may cause over-pumping of mountain aquifer, which leads to increased salting of water resources | \n\t\t\t\t\t\t\tGeopolitics | \n\t\t\t\t\t\t
12 | \n\t\t\t\t\t\t\tIndustrial pollution | \n\t\t\t\t\t\t\tFlow of industry waste, seepage of chemicals - without sufficient enforcement | \n\t\t\t\t\t\t\tManagement policy | \n\t\t\t\t\t\t
13 | \n\t\t\t\t\t\t\tCommitment to supply Jordan | \n\t\t\t\t\t\t\tShortages as a result of political commitments for water supply to neighboring countries, such as Jordan | \n\t\t\t\t\t\t\tGeopolitics | \n\t\t\t\t\t\t
14 | \n\t\t\t\t\t\t\tPolitical involvement in decision making | \n\t\t\t\t\t\t\tToo much political involvement, which disrupts the master plan development | \n\t\t\t\t\t\t\tManagement policy | \n\t\t\t\t\t\t
15 | \n\t\t\t\t\t\t\tDisregard of facilities | \n\t\t\t\t\t\t\tDisregard of pumping facilities, pipelines and other components of the water system, due to budget constraints | \n\t\t\t\t\t\t\tManagement policy | \n\t\t\t\t\t\t
16 | \n\t\t\t\t\t\t\tInadequate legislation and enforcement | \n\t\t\t\t\t\t\tInadequate legislation and enforcement allow excessive quotas, and uncontrolled pollution of water | \n\t\t\t\t\t\t\tManagement policy | \n\t\t\t\t\t\t
17 | \n\t\t\t\t\t\t\tIncrease in demand | \n\t\t\t\t\t\t\tIncrease in demand, due to population and production technology | \n\t\t\t\t\t\t\tManagement policy | \n\t\t\t\t\t\t
18 | \n\t\t\t\t\t\t\tIrrigation by effluents | \n\t\t\t\t\t\t\tGroundwater pollution, due to irrigation by low quality effluents | \n\t\t\t\t\t\t\tEnvironmental factors | \n\t\t\t\t\t\t
19 | \n\t\t\t\t\t\t\tGroundwater pollution by garbage, oil, etc. | \n\t\t\t\t\t\t\tEmbolic garbage or oil that penetrates and pollutes the groundwater | \n\t\t\t\t\t\t\tEnvironmental factors | \n\t\t\t\t\t\t
20 | \n\t\t\t\t\t\t\tEnvironmental damage to "Sea Canal" | \n\t\t\t\t\t\t\tThe "Sea Canal" is a project that aims to add sea water to the Dead Sea, either from the Mediterranean or the Red Sea. This is both an opportunity and an ecological risk to wells | \n\t\t\t\t\t\t\tGeopolitics + environmental factors | \n\t\t\t\t\t\t
21 | \n\t\t\t\t\t\t\tIncompatible utilization of Jordan or Yarmouk rivers | \n\t\t\t\t\t\t\tKeeping water agreements on both sides of the border is essential. Since the water agreements are sensitive to the geopolitical situation, one side may break the agreement, causing deterioration that could lead to a war in the area | \n\t\t\t\t\t\t\tGeopolitics | \n\t\t\t\t\t\t
22 | \n\t\t\t\t\t\t\tDevelopment suspension resulting from geopolitical reasons | \n\t\t\t\t\t\t\tThe possibility that one day Israel will transfer part of the lands in a peace agreement prevents a certain amount of system development | \n\t\t\t\t\t\t\tGeopolitics | \n\t\t\t\t\t\t
23 | \n\t\t\t\t\t\t\tGovernance crisis | \n\t\t\t\t\t\t\tManagement failures, due to political constraints, agreements and wrong decisions | \n\t\t\t\t\t\t\tManagement Policy | \n\t\t\t\t\t\t
Identified risks in the water arena
Rating the urgency and severity of risks is the second step in the risk-ranking process. To rate the risks that are presented in Table 2, questionnaires were distributed to professionals from government, academia and the industry, who are involved in the water arena in Israel. The questionnaires requested the rating of three measures for each risk: probability of occurrence, impact level of the risk, and controllability. The risk probability was measured by a Likert-type scale, ranging from 1 (Highly unlikely event) to 5 (very likely event): As for the damage function, although ideally it would have been optimal to estimate the damage function for each risk, making such estimations is a costly and time-consuming effort. Given the budget limitation for this project, only ranking was required. Impact level and Controllability were scaled between 1 and 5. The measures for controllability were ranked as follows:
\n\t\t\t\t5 - The risk is not controllable.
\n\t\t\t\t4 – The risk is difficult and expensive to control.
\n\t\t\t\t3 - The risk is partially controlled.
\n\t\t\t\t2 – The risk is controllable.
\n\t\t\t\t1 - The risk is easy to control.
\n\t\t\t\tNext, the Borda Rank (Engert, Lansdowne, 1999) was calculated. The results are summarized in Table 3.
\n\t\t\t\t\n\t\t\t\t\t\t\t | Risk | \n\t\t\t\t\t\t\tProbability | \n\t\t\t\t\t\t\tImpact | \n\t\t\t\t\t\t\tControllability | \n\t\t\t\t\t\t\tP-Rank | \n\t\t\t\t\t\t\tI-Rank | \n\t\t\t\t\t\t\tC-Rank (Reversed) | \n\t\t\t\t\t\t\tTotal P&I Ranks | \n\t\t\t\t\t\t\tFinal P&I Rank | \n\t\t\t\t\t\t\tTotal P&I&C Ranks | \n\t\t\t\t\t\t\tFinal P&I&C Rank | \n\t\t\t\t\t\t
1 | \n\t\t\t\t\t\t\tDrought | \n\t\t\t\t\t\t\t5 | \n\t\t\t\t\t\t\t3 | \n\t\t\t\t\t\t\t4 | \n\t\t\t\t\t\t\t5.5 | \n\t\t\t\t\t\t\t11.5 | \n\t\t\t\t\t\t\t15 | \n\t\t\t\t\t\t\t17 | \n\t\t\t\t\t\t\t6 | \n\t\t\t\t\t\t\t32 | \n\t\t\t\t\t\t\t14 | \n\t\t\t\t\t\t
2 | \n\t\t\t\t\t\t\tEarthquakes | \n\t\t\t\t\t\t\t1 | \n\t\t\t\t\t\t\t5 | \n\t\t\t\t\t\t\t5 | \n\t\t\t\t\t\t\t21.5 | \n\t\t\t\t\t\t\t2.5 | \n\t\t\t\t\t\t\t22 | \n\t\t\t\t\t\t\t24 | \n\t\t\t\t\t\t\t15 | \n\t\t\t\t\t\t\t46 | \n\t\t\t\t\t\t\t21 | \n\t\t\t\t\t\t
3 | \n\t\t\t\t\t\t\tLocal Terrorism - Sabotage | \n\t\t\t\t\t\t\t1 | \n\t\t\t\t\t\t\t3 | \n\t\t\t\t\t\t\t2 | \n\t\t\t\t\t\t\t21.5 | \n\t\t\t\t\t\t\t11.5 | \n\t\t\t\t\t\t\t4.5 | \n\t\t\t\t\t\t\t33 | \n\t\t\t\t\t\t\t21 | \n\t\t\t\t\t\t\t37.5 | \n\t\t\t\t\t\t\t16 | \n\t\t\t\t\t\t
4 | \n\t\t\t\t\t\t\tLocal terrorism - Poisoning | \n\t\t\t\t\t\t\t2 | \n\t\t\t\t\t\t\t5 | \n\t\t\t\t\t\t\t2 | \n\t\t\t\t\t\t\t17.5 | \n\t\t\t\t\t\t\t2.5 | \n\t\t\t\t\t\t\t4.5 | \n\t\t\t\t\t\t\t20 | \n\t\t\t\t\t\t\t9 | \n\t\t\t\t\t\t\t24.5 | \n\t\t\t\t\t\t\t7 | \n\t\t\t\t\t\t
5 | \n\t\t\t\t\t\t\tReservoir evaporation | \n\t\t\t\t\t\t\t5 | \n\t\t\t\t\t\t\t1 | \n\t\t\t\t\t\t\t5 | \n\t\t\t\t\t\t\t5.5 | \n\t\t\t\t\t\t\t22 | \n\t\t\t\t\t\t\t22 | \n\t\t\t\t\t\t\t27.5 | \n\t\t\t\t\t\t\t17 | \n\t\t\t\t\t\t\t49.5 | \n\t\t\t\t\t\t\t23 | \n\t\t\t\t\t\t
6 | \n\t\t\t\t\t\t\tAgricultural pollution | \n\t\t\t\t\t\t\t5 | \n\t\t\t\t\t\t\t1 | \n\t\t\t\t\t\t\t2 | \n\t\t\t\t\t\t\t5.5 | \n\t\t\t\t\t\t\t22 | \n\t\t\t\t\t\t\t4.5 | \n\t\t\t\t\t\t\t27.5 | \n\t\t\t\t\t\t\t17 | \n\t\t\t\t\t\t\t32 | \n\t\t\t\t\t\t\t14 | \n\t\t\t\t\t\t
7 | \n\t\t\t\t\t\t\tPreventing water seepage | \n\t\t\t\t\t\t\t4 | \n\t\t\t\t\t\t\t4 | \n\t\t\t\t\t\t\t2 | \n\t\t\t\t\t\t\t12 | \n\t\t\t\t\t\t\t6 | \n\t\t\t\t\t\t\t4.5 | \n\t\t\t\t\t\t\t18 | \n\t\t\t\t\t\t\t7 | \n\t\t\t\t\t\t\t22.5 | \n\t\t\t\t\t\t\t6 | \n\t\t\t\t\t\t
8 | \n\t\t\t\t\t\t\tDiversion of transboundary water resources | \n\t\t\t\t\t\t\t2 | \n\t\t\t\t\t\t\t5 | \n\t\t\t\t\t\t\t3 | \n\t\t\t\t\t\t\t17.5 | \n\t\t\t\t\t\t\t2.5 | \n\t\t\t\t\t\t\t7.5 | \n\t\t\t\t\t\t\t20 | \n\t\t\t\t\t\t\t9 | \n\t\t\t\t\t\t\t27.5 | \n\t\t\t\t\t\t\t10 | \n\t\t\t\t\t\t
9 | \n\t\t\t\t\t\t\tClimate changes | \n\t\t\t\t\t\t\t1 | \n\t\t\t\t\t\t\t5 | \n\t\t\t\t\t\t\t5 | \n\t\t\t\t\t\t\t21.5 | \n\t\t\t\t\t\t\t2.5 | \n\t\t\t\t\t\t\t22 | \n\t\t\t\t\t\t\t24 | \n\t\t\t\t\t\t\t15 | \n\t\t\t\t\t\t\t46 | \n\t\t\t\t\t\t\t21 | \n\t\t\t\t\t\t
10 | \n\t\t\t\t\t\t\tChanges in the distribution of rain | \n\t\t\t\t\t\t\t2 | \n\t\t\t\t\t\t\t1 | \n\t\t\t\t\t\t\t3 | \n\t\t\t\t\t\t\t17.5 | \n\t\t\t\t\t\t\t22 | \n\t\t\t\t\t\t\t7.5 | \n\t\t\t\t\t\t\t39.5 | \n\t\t\t\t\t\t\t23 | \n\t\t\t\t\t\t\t47 | \n\t\t\t\t\t\t\t22 | \n\t\t\t\t\t\t
11 | \n\t\t\t\t\t\t\tOver-pumping the mountain aquifer | \n\t\t\t\t\t\t\t5 | \n\t\t\t\t\t\t\t4 | \n\t\t\t\t\t\t\t1 | \n\t\t\t\t\t\t\t5.5 | \n\t\t\t\t\t\t\t6 | \n\t\t\t\t\t\t\t2 | \n\t\t\t\t\t\t\t11.5 | \n\t\t\t\t\t\t\t1 | \n\t\t\t\t\t\t\t13.5 | \n\t\t\t\t\t\t\t1 | \n\t\t\t\t\t\t
12 | \n\t\t\t\t\t\t\tIndustrial pollution | \n\t\t\t\t\t\t\t5 | \n\t\t\t\t\t\t\t2 | \n\t\t\t\t\t\t\t3 | \n\t\t\t\t\t\t\t5.5 | \n\t\t\t\t\t\t\t18 | \n\t\t\t\t\t\t\t7.5 | \n\t\t\t\t\t\t\t23.5 | \n\t\t\t\t\t\t\t13 | \n\t\t\t\t\t\t\t31 | \n\t\t\t\t\t\t\t12 | \n\t\t\t\t\t\t
13 | \n\t\t\t\t\t\t\tCommitment to supply Jordan | \n\t\t\t\t\t\t\t3 | \n\t\t\t\t\t\t\t2 | \n\t\t\t\t\t\t\t3 | \n\t\t\t\t\t\t\t14.5 | \n\t\t\t\t\t\t\t18 | \n\t\t\t\t\t\t\t7.5 | \n\t\t\t\t\t\t\t32.5 | \n\t\t\t\t\t\t\t20 | \n\t\t\t\t\t\t\t40 | \n\t\t\t\t\t\t\t17 | \n\t\t\t\t\t\t
14 | \n\t\t\t\t\t\t\tPolitical involvement in decision making | \n\t\t\t\t\t\t\t5 | \n\t\t\t\t\t\t\t3 | \n\t\t\t\t\t\t\t2 | \n\t\t\t\t\t\t\t5.5 | \n\t\t\t\t\t\t\t11.5 | \n\t\t\t\t\t\t\t4.5 | \n\t\t\t\t\t\t\t17 | \n\t\t\t\t\t\t\t6 | \n\t\t\t\t\t\t\t21.5 | \n\t\t\t\t\t\t\t5 | \n\t\t\t\t\t\t
15 | \n\t\t\t\t\t\t\tDisregard of facilities | \n\t\t\t\t\t\t\t5 | \n\t\t\t\t\t\t\t3 | \n\t\t\t\t\t\t\t1 | \n\t\t\t\t\t\t\t5.5 | \n\t\t\t\t\t\t\t11.5 | \n\t\t\t\t\t\t\t2 | \n\t\t\t\t\t\t\t17 | \n\t\t\t\t\t\t\t6 | \n\t\t\t\t\t\t\t19 | \n\t\t\t\t\t\t\t2 | \n\t\t\t\t\t\t
16 | \n\t\t\t\t\t\t\tInadequate legislation and enforcement | \n\t\t\t\t\t\t\t5 | \n\t\t\t\t\t\t\t3 | \n\t\t\t\t\t\t\t2 | \n\t\t\t\t\t\t\t5.5 | \n\t\t\t\t\t\t\t11.5 | \n\t\t\t\t\t\t\t4.5 | \n\t\t\t\t\t\t\t17 | \n\t\t\t\t\t\t\t6 | \n\t\t\t\t\t\t\t21.5 | \n\t\t\t\t\t\t\t5 | \n\t\t\t\t\t\t
17 | \n\t\t\t\t\t\t\tIncrease in demand | \n\t\t\t\t\t\t\t5 | \n\t\t\t\t\t\t\t2 | \n\t\t\t\t\t\t\t1 | \n\t\t\t\t\t\t\t5.5 | \n\t\t\t\t\t\t\t18 | \n\t\t\t\t\t\t\t2 | \n\t\t\t\t\t\t\t23.5 | \n\t\t\t\t\t\t\t13 | \n\t\t\t\t\t\t\t25.5 | \n\t\t\t\t\t\t\t9 | \n\t\t\t\t\t\t
18 | \n\t\t\t\t\t\t\tIrrigation by effluents | \n\t\t\t\t\t\t\t3 | \n\t\t\t\t\t\t\t4 | \n\t\t\t\t\t\t\t2 | \n\t\t\t\t\t\t\t14.5 | \n\t\t\t\t\t\t\t6 | \n\t\t\t\t\t\t\t4.5 | \n\t\t\t\t\t\t\t20.5 | \n\t\t\t\t\t\t\t10 | \n\t\t\t\t\t\t\t25 | \n\t\t\t\t\t\t\t8 | \n\t\t\t\t\t\t
19 | \n\t\t\t\t\t\t\tGroundwater pollution by garbage , oil, etc. | \n\t\t\t\t\t\t\t5 | \n\t\t\t\t\t\t\t3 | \n\t\t\t\t\t\t\t2 | \n\t\t\t\t\t\t\t5.5 | \n\t\t\t\t\t\t\t11.5 | \n\t\t\t\t\t\t\t4.5 | \n\t\t\t\t\t\t\t17 | \n\t\t\t\t\t\t\t6 | \n\t\t\t\t\t\t\t21.5 | \n\t\t\t\t\t\t\t5 | \n\t\t\t\t\t\t
20 | \n\t\t\t\t\t\t\tEnvironmental damage to "Sea Canal" | \n\t\t\t\t\t\t\t1 | \n\t\t\t\t\t\t\t2 | \n\t\t\t\t\t\t\t2 | \n\t\t\t\t\t\t\t21.5 | \n\t\t\t\t\t\t\t18 | \n\t\t\t\t\t\t\t4.5 | \n\t\t\t\t\t\t\t39.5 | \n\t\t\t\t\t\t\t23 | \n\t\t\t\t\t\t\t44 | \n\t\t\t\t\t\t\t19 | \n\t\t\t\t\t\t
21 | \n\t\t\t\t\t\t\tIncompatible utilization of Jordan or Yarmouk rivers | \n\t\t\t\t\t\t\t2 | \n\t\t\t\t\t\t\t3 | \n\t\t\t\t\t\t\t4 | \n\t\t\t\t\t\t\t17.5 | \n\t\t\t\t\t\t\t11.5 | \n\t\t\t\t\t\t\t15 | \n\t\t\t\t\t\t\t29 | \n\t\t\t\t\t\t\t18 | \n\t\t\t\t\t\t\t44 | \n\t\t\t\t\t\t\t19 | \n\t\t\t\t\t\t
22 | \n\t\t\t\t\t\t\tDevelopment suspension from geopolitical reasons | \n\t\t\t\t\t\t\t4 | \n\t\t\t\t\t\t\t2 | \n\t\t\t\t\t\t\t2 | \n\t\t\t\t\t\t\t12 | \n\t\t\t\t\t\t\t18 | \n\t\t\t\t\t\t\t4.5 | \n\t\t\t\t\t\t\t30 | \n\t\t\t\t\t\t\t19 | \n\t\t\t\t\t\t\t34.5 | \n\t\t\t\t\t\t\t15 | \n\t\t\t\t\t\t
23 | \n\t\t\t\t\t\t\tGovernance crisis | \n\t\t\t\t\t\t\t4 | \n\t\t\t\t\t\t\t3 | \n\t\t\t\t\t\t\t2 | \n\t\t\t\t\t\t\t12 | \n\t\t\t\t\t\t\t11.5 | \n\t\t\t\t\t\t\t4.5 | \n\t\t\t\t\t\t\t23.5 | \n\t\t\t\t\t\t\t13 | \n\t\t\t\t\t\t\t28 | \n\t\t\t\t\t\t\t11 | \n\t\t\t\t\t\t
The Risks - Ranking.Notes: The pink cells indicate the top ten threatening risks.
In Table 3, the three aspects associated with any risk - the probability, the impact and the controllability - were derived from experts\' assessments, after which rounded averages of these assessments were calculated. Then, the Borda Rank was calculated for each factor, (presented in columns P-rank for probability, I-rank for impact and C-rank for controllability). In order to explain the Borda Rank, a demonstration may be useful. Consider the P-rank column. There are 10 risks, whose probability is ranked 5 (very high). They are ordered from 1 to 10 with average of 5.5. Therefore, these 10 risks are assigned a P-rank of 5.5. There are 3 risks that are given a rank of 4 (high probability of occurrence). Therefore, they are ordered 11, 12, and 13 and their average order is 12. These 3 risks are assigned a P-rank of 12. The same procedure is iterated for the 2 risks whose probability was ranked as 3. They are given the order 14 and 15 and their assigned P-rank is 14.5. In the same manner, risks at probability group 2 are assigned a P-rank of 17.5. The last group, probability 1, is assigned a P-rank of 21.5. The same calculations are applied for the I-rank.
\n\t\t\t\tThe C-rank is calculated in reverse order. Contrary to the impact and probability ranking, controllability’s high rank implies a lower priority. Thus, low rank should increase its priority of response. Therefore, the 3 risks with a controllability rank of 1 are assigned as order 2 in the C-rank, while the most non-controllable risks, ranked at controllability 5, are assigned a C-rank of 22.
\n\t\t\t\tThe sum of the P-rank and I-rank is displayed in the column named "Total P&I Ranks". This column is ranked into the column named "Final Rank of P&I". The meaning of this rank is that the lowest value should be handled with high priority, e.g. risk number 11 - “over-pumping the mountain aquifer" - which has a very high probability of occurring and high impact and damage rankings - should be handled first. The ranking is calculated using "Risk Matrix" software (Engert, Lansdowne, 1999). The column "Final Rank of P&I" provides the priorities of handling risks based on their probability and impact. It is presented such that the lowest ranks should be handled with high priority.
\n\t\t\t\tAll three ranks - P-rank, I-rank and C-rank - are summed in the column named "Total P&I&C Ranks". This column is ranked into the column named "Final Rank of P&I&C", which is a measure that acknowledges all three risk criteria - probability, impact and controllability. The final rank is actually in reverse order (the lower the final rank, the higher its priority).
\n\t\t\t\n\t\t\t\t\tTable 3 indicates that although in this case the addition of the C-rank did not alter the order of risks substantially, the result is that it eliminated uncontrollable risks that have high priority and enable the handling of other risks with higher potential benefit. Figure 1 shows the two final ranks, after sorting the list of risks. The risks were ordered (sorted) by their P&I&C ranks.
\n\t\t\t\tFinal Ranks of all the risks.
The figure shows that most risks follow the same trend. Namely, risks with high priority, according to the final P&I rank, will have a high priority, according to the final P&I&C rank, and vice versa. The risk with the lowest rank is "over-pumping the mountain aquifer" (see Table 3). This risk has a high probability, since this aquifer is utilized by both the Israeli and the Palestinians; this risk also has a high impact and is controllable within the framework of the existing legal situation (even though the laws are not currently enforced). According to the P&I rank, the second risk to be handled is drought. Drought is not among the top 10 risks, according to the P&I&C rank, since it is hardly controllable. Hence, the only thing that the government does regarding this risk is to insure farmers for crop losses.
\n\t\t\t\tIn Table 3, classifying the risks into categories (natural causes, geopolitics, management policy, water security, and environmental factors) is helpful in analyzing groups of risks, instead of individual risks. The difference between the P&I rank and the P&I&C rank, may be better understood by a comparison of the average of these ranks over each risk category. The difference between the two ranks is shown in Figure 2. For each category of risks, the average of the P&I rank and the P&I&C rank value is presented. In addition, the number of risks in each category is added to the category name.
\n\t\t\t\tIt can be seen that the addition of controllability decreased the average rank of the "natural caused" category and increased all the other categories. This is because according to the expert opinion, risks derived from natural causes are mostly non-controllable; therefore, it is less effective to develop any response plan for them. In this case, although the average P&I rank is high, these risks\' priority is reduced. On the other hand, the priorities among the other groups remain the same, where the groups of environmental factors and management policy risks have the lowest average ranks, and thus should be addressed first.
\n\t\t\tAverage ranks of all the categories risks.
According the P&I&C rank of the risks, as presented in Table 3, the most threatening risks are: "Lack of coordination in water usage", "Disregard of facilities", "Political involvement in decision making", "Inadequate legislation and enforcement", and "Groundwater pollution by garbage, oil, etc." The first risk is a very common geopolitical problem, but its impact has not yet been fully understood. The other risks can be resolved by management policies and law enforcement. Risks like drought or earthquakes do not appear in the high priority part of the table, due to their lack of controllability and low probably of occurrence (earthquakes).
\n\t\t\t\tIt is interesting to note that most of the natural risks, such as earthquakes, climate changes, changes in the distribution of rainfall, and reservoir evaporation are located in the low priority part of the table. This is mainly due to a lack of controllability and either low probability or low impact. The controllability criteria assigned them a more realistic priority. It should be mentioned that the experts contacted in this research claimed that these are very important risks that should be handled carefully. However, they could not provide a solution for addressing the issues concerning these risks. The incorporation of the controllability criterion captures this dichotomy.
\n\t\t\tEfficient and flexible management of fresh water resources are critical for the wellbeing of human society. Without it, human society would be unable to prosper or even exist. Conflicting demands coupled with decreasing usable water may lead to inefficient and unsustainable use of resources, which may result in significant economic, social, and environmental ramifications. In the current work, risk management methodology is utilized to increase flexibility and security over the management of water resources.
\n\t\t\tSince by their very nature many water resources are often associated with risks that are not readily controllable, a modification of the standard risk management methodology was adopted. This modification allows the accounting for the ability or inability to control the risk under consideration at an early stage of the planning. The controllability of the risk is incorporated among the risk identification parameters in order to avoid dealing with risks that are a priori non-controllable.
\n\t\t\tThe risk management of any water resource must address two large systems: the natural ecological system and the human societies that utilize the resource. Thus, it follows that the risks involved in the maintenance of water systems also involve both natural risks, as well as risks associated with the ways in which societies utilize the water and the values which humans attribute to it. Furthermore, the social values, beliefs and arrangements involved in the utilization of any fresh water resource serve to expand potential adaptation strategies, on one hand, while presenting challenges and social constraints regarding possible risk mitigation strategies by the other hand. They are restricted to the society’s ability to employ different means of adaptation over time, at different stages of risk management, and in response to different perceptions about what constitutes the challenges that must be met.
\n\t\t\tTo better illustrate the approach, a study on the risks associated with the management of water resources in Israel is presented. In order to understand the possible risks and their magnitude, experts\' opinions were solicited. It turned out that the risks can be classified into five main groups: natural causes, geopolitics, management policy, water security, and environmental factors. Incorporating the controllability criterion into the risk assessment decreases the importance of the environmental risks, since according to the experts\' opinions these are difficult or impossible to control. These natural risks are the most common risks for water resource management. Usually, these risks do not appear in the classical projects\' risk analyses. Having a sizable natural environmental aspect, water systems are more susceptible to natural risks than commercial projects. The introduction of controllability criterion enables the government to identify and focus on responding to the most threatening risks requiring attention and action. Some of the risks that were initially assumed to be high risks are those of sabotage and terror attacks. These risks, however, were actually found to have a low impact and may be controlled in a relatively easy manner. Unlike environmental risks, risks of pollution and geopolitical risks can be controlled; therefore, their rank was enhanced by the introduction of the controllability criterion.
\n\t\t\tThis chapter demonstrates the incorporation of the controllability criterion at the assessment stage of risk management. Future studies conducted in other settings should further explore the effectiveness and usefulness of this modification - for risk management of water resources in particular - and for any other type of project management in general.
\n\t\tAccording to the World Health Organization (WHO), psychiatric disorders (PDs) comprise a broad range of dysfunctions, with several and some common symptoms. PDs are generally characterized by the combination of symptoms as abnormal thoughts, emotions, behavior, and social interaction. The most common PDs include schizophrenia (SCZ), bipolar disorder (BD), major depression disorder (MDD), attention deficit hyperactivity disorder (ADHD), intellectual disabilities, drug abuse disorders, among others [1].
There are several reasons to use animal models in the studies of disorders affecting the brain. The poor understanding of the etiopathogenesis and pathophysiology of PDs is clearly reflected by the unmet clinical need for better pharmacological treatments. Therefore, good models are clearly needed to clarify the neurobiology involved in PDs, as well as for the identification of biomarkers useful to assist diagnosis and/or for the development of novel therapies. It is also implausible to move forward in clinical trials with a novel drug tested only in a cell model, without any evidence about its efficacy in animal experiments. The value of animal models to drug development has been demonstrated empirically. For example, the first and the most efficacious drugs available for complex PDs such as SCZ (e.g., chlorpromazine and clozapine) was discovered observing the alterations in behaviors of experimental animals in response to each drug administration. In fact, in the last decades, most of the CNS drugs approved were discovered employing a phenotypic screening approach in animal models [2, 3].
A reliable animal model must share several similarities with the studied target to allow a successful translation from the basic to the clinical research. However, several limitations need to be overcome. First, the heterogeneous behavioral symptom characteristics of PDs are in some grade uniquely expressed in humans, and they are certainly impossible to be reproduced authentically in animals as rodents, fishes or worms [4]. Second, there is a lack of an objective measure to unequivocally diagnose mental illness [5], which adds complexity to the modeling any mental disorder in experimental animals. Third, in order to develop meaningful animal models for PDs with potential translational power, the disease phenotypes must be represented in the experimental animals. The selection and update of these phenotypes, in agreement with the recent findings in clinical psychiatry and neuroscience, represents a challenge, as evidenced by the recognized gap between the clinical and basic scientific research [6]. In addition, a rising question is what are the specific traits or phenotypes that an animal model should express to be translatable to specific disorder? (Figure 1).
The traditional approach to establish an animal model in PDs is based on three classic constructs proposed by Willner in 1984: face validity, which determines how much a phenotype presented by a patient is represented by the animal model (corresponds to similarity between the model and the PDs assessed, that includes symptoms, signs, and pharmacological features); construct validity, which demonstrates whether it is possible to reproduce the pathological condition based on processes that are already known to be altered (correspondence between the physiological dysfunctions in the human population and in the animal model); predictive validity, which tries to evaluate if a pharmacological or non-pharmacological intervention is capable to reverse the pathological condition (in other words, if the treatment that is effective in reversing PDs in humans would reverse the changes seen in animals) [7, 8, 9, 10]. However, in practice, no animal models fully meet these three criteria of validity.
Many authors have proposed that instead of these three proposed criteria defining an external validation, in addition, the validity of an animal model should not be simply organisms that resemble human dysfunction, but they would also reproduce the processes by which animals and humans enter this state, and therefore, this could be better exploited by adding a new validation criteria [9]. For instance, the validity by homology, which proposes, for instance, an invertebrate model, such as
There is a consensus about the low reliability of the diagnostic construct provided for the employment of Diagnostic and Statistical Manual of Mental Disorders or DMS (which is a manual that determines the criteria for the clinical diagnosis of PDs). The heterogeneity implicit in this classification system and the imprecise quantification of the symptoms make it impossible to deconstruct PDs within model organisms. In fact, an etiology-based nosology system has been advocate for psychiatry, and it has been proposed to identify the endophenotypes that occur in both healthy individuals and subjects with different psychopathologies [14]. Endophenotypes are basically quantitative trait-like deficits that are possible to assess by laboratory-based methods rather than by clinical observation. An endophenotype should be state-independent, heritable, occurring at a high rate in affected families, and in addition, it should be associated to genetic variants of the disorder, as it should be involved the same brain circuits associated with the symptoms of the illness in patients (Table 1).
Endophenotype | Description | What can be evaluated |
---|---|---|
Locomotor activity | Distance travelled, time spent, and frequency of the movements measured during or after a habituation period or after some stimuli (i.e. drug administration) | Behavioral sensitization (BD; ADHD; SCZ); Depressive-like behaviors (MDD); etc… |
Latent inhibition | Latent inhibition is the ability of a pre-exposed nonreinforced stimulus to inhibit later stimulus-response learning | Cognitive impairments (SCZ); etc… |
Pre-pulse inhibition (PPI) | Decrease of the startle reflex after exposure to a pre-pulse before the pulse | Cognitive impairments (SCZ); etc… |
Working memory and learning | Describes short-term memory, in a olfactory domain and spatial domain | Cognitive impairments (PDs in general); etc… |
Social interaction | Evaluation of time spent on exploring a social stimulus. | Anxiety-like behaviors; Depressive-like behaviors; etc… |
Rearing | Measure of activity, investigation and exploratory behavior induced by a drug or/and novelty | Anxiety-like behaviors; etc… |
Grooming | A maintenance behavior evaluated by the cleaning of the fur; is displayed as reaction to unexpected stimuli and in conflict situations | Anxiety-like behaviors; Depressive-like behaviors; etc… |
Aggressiveness | Evaluation of attack and defensive behavior as reaction to a stimuli or other animal | Anxiety-like behaviors; Depressive-like behaviors; etc… |
Food intake | Amount of food ingested by the animal | Anxiety-like behaviors; Depressive-like behaviors; etc… |
Sucrose preference test | Assesses the sensitivity to reward based on the rodent’s natural preference for sweets. This test measures the amount of a sweet-tasting solution that the animal ingests | Depressive-like behaviors; etc… |
Fear conditioning | Classical conditioning paradigm, in which an aversive stimulus is paired with some neutral stimuli. Used to assess associative fear learning and memory in rodents. | Cognitive impairments (PDs in general); etc… |
Forced swim test | Measures the scoring of swimming and climbing (active behavior), and immobility (passive behavior) when animals are placed in an inescapable cylinder filled with water | Depressive-like behaviors; etc… |
Most common endophenotypes used to evaluate behaviors associated with psychiatric disorders (PDs).
Different approaches to construct animal models for neuropsychiatric disorders studies.
The Research Domains Criteria (RDoC) framework was introduced as an alternative categorization system for psychopathological states [15, 16, 17]. This system provides a platform to improve the translatability of studies from animals to humans, since it supports the endophenotype-based comparison of animals and humans on an objective neurobiological basis across all behavioral domains. In fact, the endophenotypes have been reverse-translated into animal models successfully and allows the evaluation of the neural neurobiological substrates and their circuit dysfunctions [18]. Thus, it has been demonstrated that the modeling of neurobiological and behavioral endophenotypes to reproduce PDs in experimental animals is possible.
The ideal animal model should be derived from risk factors or the causative agent of the human disease. One of the strategies used during the construction of a model is focused on a specific factor that can reproduce the condition as a whole or an aspect of the disease [19]. The choice for the methodology used in establishing a model is fundamentally important to guide which aspect of the disease should be explored, and it is an essential component in the validation of a model known as construct validity.
In the following sections, selected examples of animal models used in the context of investigating PDs will be demonstrated, indicating which changes are observed in behavioral and molecular levels.
Schizophrenia (SCZ) is a severe brain disorder, characterized by a set of positive and negative symptoms and cognitive disorders, which are the basis for the clinical diagnosis of individuals who needs to present at least two or more of those symptoms, according to the DSM. SCZ is one of the most debilitating mental disorders, affecting about 21 million people worldwide. The antipsychotics used to treat SCZ patients can soften the development of the disorder, and this pharmacological treatment was the basis for the most accepted theory to explain the neurobiology of SCZ, as noticed by the alterations in the dopamine transmission. In addition, several other theories have been suggested soon after, as for instance, the serotoninergic, glutamatergic, GABAergic, and the neurodevelopmental susceptibility hypothesis, among others [20]. However, none of these theories had allowed the characterization of the etiology or the identification of strong biomarker for the diagnosis of SCZ. Many efforts are being made to characterize a model for SCZ, but there is a great difficulty in reproduce endophenotypes that frame all the groups of symptoms related to this disease, or which allow associating all risk factors that are already known. Below, we exemplify some of these models, and for a more detailed review of SCZ models can be found elsewhere [21].
Most of the models are based on the theory of neurotransmitter imbalance, and they are induced by the disruption of these pathways, other models explore changes in the levels of expression of candidate genes involved in the processes of SCZ susceptibility. It should be considered that SCZ is a multifactorial disorder, and thus, the genetic component should be evaluated in addition to changes in the environment, as in contrast to the models based on genetic alterations, there are those taking into account the environmental changes, such as the prenatal insults, which impose changes in the neurodevelopment processes. Some of these models are exemplified in Table 2.
Model | Endophenotype | Molecular alterations | References |
---|---|---|---|
Amphetamine model of SCZ | ↓ Latent inhibition; ↑ locomotion Same as acute but with ↓ PPI | ↑ Mesolimbic dopamine response; ↑ Acetilcholine in PFc | [22, 23, 24, 25, 26] |
Glutamatergic manipulation (Phencyclidine; MK-801; Ketamine) | ↑ Locomotion; ↓ working memory; ↓ Reversal learning performance; ↓ Social interaction; ↓ PPI | ↓ PV-immunoreactive neurons in PFc and hippocampus | [27, 28, 29] |
Missense mutations models | ↓ PPI; ↓ latent inhibition; ↑ Depressive-like phenotype | ↓ Brain volume; ↓ PDE4B activity and binding to DISC1; ↓ PV-immunoreactive; ↓ Dendritic density | [30, 31, 32] |
Dominant-negative isoforms of DISC1 | ↑ Amphetamine sensibility; ↓ working memory | ↓ Dopamine, DOPAC; ↓ PV-immunoreactive | [33, 34] |
Knockdown | ↑ Amphetamine sensibility; ↓ PPI; ↓ working memory | ↓ Dopamine; ↓ PV-immunoreactive | [35] |
Overexpression | ↑ Amphetamine sensibility; ↑ rearing behavior; ↑ locomotion; ↓ learning in rotarod task | ↑ Increase in high-affinity D2R; ↑ Translocation of dopamine transporter; ↑ Dopamine inflow | [36] |
Knock-out | ↑ Amphetamine sensibility; ↑ locomotion; ↓ PPI; ↓ Working memory; ↓ social interaction | ↓ Hippocampal spine density; ↑ Lateral ventricles; ↑ HVA/DA ratio; ↑ Excitability of PFc pyramidal neurones | [37, 38, 39] |
Neonatal excitotoxic hippocampal lesion | ↓ PPI; ↓ Working memory; ↓ Social interaction; ↑ Amphetamine sensibility; ↑ MK-801/PCP sensibility; ↑ locomotion | ↑ Mesolimbic dopamine response; ↑ Acetilcholine in PFc | [40, 41] |
Methylazomethanol (MAM) and polyinosinic-polycytidylic acid (poly I:C) | ↑ Locomotion;↑ Amphetamine sensibility;↑ MK-801/PCP sensibility; ↓ Social interaction; ↓ PPI; ↓ Working memory | ↓ PV-immunoreactive neurons in PFc and hippocampus | [42, 43, 44] |
Some examples of SCZ models induced by drugs, genetic manipulation, and prenatal insults.
All of these models show behavioral and molecular changes that can be associated with SCZ.
PPI = prepulse inhibition; PFc = prefrontal cortex; PV = parvalbumin; PDE4B = cAMP-specific 3",5"-cyclic phosphodiesterase 4B; DISC1 = disrupted-in-schizophrenia 1; DOPAC = dihydroxyphenylacetic acid; HVA = homovanillic acid; DA = dopamine; poly I:C = Polyinosinic:polycytidylic acid.
All of these models show behavioral and molecular changes that can be associated with SCZ.
Major depressive disorder (MDD) is a common, complex, and heterogeneous mental disorder, characterized by persistent sadness and loss of interest in general activities, affecting about 10% of the population worldwide, and which is caused by multifactorial mechanisms not fully understood yet, characterizing MDD as a disorder with many variations in clinical features among the patients, imposing a consequent high variability in the diagnosis, time course of response and remission [45], which is one of the main reasons justifying the intensive search for animal models and biomarkers, aiming for advances in MDD diagnosis [46]. In addition, these advances could be helpful for a better classification for depressive spectrum, and thereby for improving the treatment [47]. The animal models of depression have been developed based on acute or chronic stress exposure, exogenous administration of glucocorticoids, injuries in brain regions and/or genetic manipulations [48, 49, 50]. There is a great variation in the number of protocols that can be used to induce these changes, in which the stressor, time of exposure to the stimulus, and other parameters may vary. For more detailed review of MDD models, see also [51] (Table 3).
Model | Endophenotype | Molecular alterations | References |
---|---|---|---|
Learned Helplessness | ↓ Locomotion; ↑ aggressiveness ↓ Grooming; ↓ response to rewards ↑ Sleep disturbance | ↓ Norepinephrine ; ↑ BDNF; aberrant miRNA brain- region specific expression | [52, 53, 54, 55, 56, 57] |
Unpredictable chronic mild stress | ↓ Food intake; ↓ growth rate; ↓ Locomotion; ↑ aggressiveness; ↓ Response to rewards | ↑ Corticosterone; ↓ glucocorticoid receptor expression; ↓ endogenous ATP | [58, 59, 60, 61] |
Chronic restraint stress model | ↑ Aggressiveness; ↑ fear conditioning; ↓ locomotion; ↓ food intake | ↑ CA3 dendritic atrophy and damage; ↓ neurogenesis in dentate gyrus; ↑ apoptotic cell death; ↑ corticosteroid | [62, 63, 64] |
Social defeat | ↓ Locomotion; ↓ exploratory activity; ↓ Aggression; ↓ sexual behavior; ↑ Anhedonia; ↑ sleep disturbance ; ↓ Growth rate | ↓ Volume and cell proliferation in hippocampus and PFc; ↑ corticosteroid; ↓ serotonin; ↓ BDNF | [65, 66, 67] |
Early life stress model | ↑ Anxiety-like behavior; ↑ Depression-like behavior; ↑ Novelty responsivity | ↑ BDNF expression PFC and hippocampus | [68, 69] |
Olfactory bulbectomy | ↑ Locomotion; ↓ working memory; ↓ response to rewards; ↓ food intake; ↑ sleep disturbance; ↑ responsivity to stressors | Dysfucntion in HPA and neuro-immune axis; ↓ neurotransmitters; ↑ neuronal degeneration; ↑ BDNF; ↓ neuropeptides | [70, 71] |
Wistar-Kyoto | ↓ Locomotion; ↑ immobility in forced swim test; ↑ social avoidance; ↑ freezing to context | ↑ Adrenal glands; ↑ corticosterone | [72, 73] |
Flinders Sensitive Line rat | ↓ Activity in enclosed arena; ↑ immobility in forced swim test; ↓ sucrose intake under stress | ↓ Serotonin synthesis; dysfunction in dopaminergic and noradrenergic systems | [74, 75, 76, 77] |
Examples of models for MDD induced by stressors, injuries in brain regions, and by selective inbreeding.
BDNF = brain-derived neurotrophic factor; miRNA = microRNA; ATP = adenosine triphosphate; PFc = prefrontal cortex; HPA = hypothalamic–pituitary–adrenal axis.
Bipolar disorder (BD) is a chronic mood disorder, characterized by fluctuations between mania and depressive episodes, which affects approximately 1% of the global population irrespective of nationality, ethnic origin, or socioeconomic status [78]. Due to the complex mood alterations, misdiagnosis in BD is very common, as other mental illnesses as depression and SCZ share several common symptoms, in addition to the specific and common endophenotypes and brain structural changes [79, 80]. The search for advances in diagnosis is important for these disorders, since early diagnosis would be essential to foster earlier suited pharmacological treatment in BD, which was proved to be beneficial to prevent the cognitive deficits and disabilities in these BD patients [81], as also demonstrated for SCZ patients [82]. The major limitation in evaluating a model for BD is the difficulty in reproducing the phases of mania and depression observed in the clinic. Many of these models present only one of these parameters, and they are often developed by genetic alterations in genes known to be involved in this disorder or stressors, mainly involved in the circadian cycle as also demonstrated for other PDs. Another interesting approach used for the development of animal models for BD is the one induced by psychostimulant sensitization (which causes mania-like behavior), as withdrawal from psychostimulants is accompanied by depressive-like behavior, which together leads to changes and compulsory behaviors. Some of these models are exemplified in Table 4. A more detailed review of BD models can be found elsewhere [93].
Model | Endophenotype | Molecular alterations | References |
---|---|---|---|
BDNF haploinsufficient | ↑ Locomotion; ↑ agressive behavior; ↑ food intake | ↓ Brain volume; ↓ BDNF; ↓ dopamine | [83, 84] |
ERK1 Knock-out | ↑ Amphetamine sensibility; ↓ learing in fear conditioning; ↑ locomotion; ↓ immobility in forced swim | ↓ Phospho-RSK1/3 in PFC and striatum; shift of activity rhythm | [85, 86] |
DAT Knock-down | ↑ Locomotion; ↓ anxiety; ↑ rearing | ↑ Dopamine | [87, 88, 89] |
Sleep deprivation | ↑ Locomotion; ↑ agressive behavior; ↑ exploratory behavior | — | [90, 91] |
Photoperiod lenghts | ↑ Anxiety; ↑ helplessness | Switch in dopamine neurotransmission to somatostatin | [92] |
Chronic amphetamine administration followed by withdrawal | ↑ Locomotion; ↑ anxiety; ↑ anhedonia; ↓ motivation; ↓ working memory | ↓ Dopamine responsiveness ↑ serotonin sensitivty | [94, 95, 96] |
Examples of models for BD induced by genetic manipulation, environmental stressors, and induced by sensitization, which lead to some aspects of molecular and behavioral changes related to BD.
BDNF = brain-derived neurotrophic factor; ERK1 = Extracellular signal-regulated kinase 1; DAT = dopamine transporter.
BDNF = brain-derived neurotrophic factor; ERK1 = Extracellular signal-regulated kinase 1; DAT = dopamine transporter.
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder, affecting approximately 2.2–2.8% of worldwide, with multifactorial inducement, as reflected by the heterogeneity found in this disorder, and as indicated by the diversity in its psychiatric comorbidities [97]. This disorder is defined by inappropriate levels of attention deficits and/or hyperactivity behavior, which directly interfere with the normal life and functioning of an individual [98]. While there is no cure for ADHD, currently available treatments can help reducing the symptoms and improving the general functioning, although with a peculiar wide variability due to the clinically and scientifically difficulties to exactly determine the specificity and the origin of the symptoms [99]. As for other PDs, due to the high heritability, animal models for ADHD are mostly derived from genetic alterations or breeding selection or from neonatal insults that can lead to neurodevelopmental changes. Models related to dopaminergic neurotransmission are also important to evaluate ADHD, as also listed in Table 2, and which includes the administration of psychostimulants as amphetamine. A more detailed review on ADHD animal models can be found elsewhere [100] (Table 5).
Model | Endophenotype | Molecular alterations | References |
---|---|---|---|
Spontaneously hypertensive rats | ↓ Attention; ↑ motor impulsiveness ↑ Locomotion; ↑ exploratory behavior | ↑ Dopamine ↓ Dopamine transporter 1 expression ↓ Brain volume | [101, 102, 103, 104] |
Coloboma mouse mutant | ↑ Locomotion; ↑ exploratory behavior; ↑ amphetamine sensibility | ↑ Noraedrenergic function ↓ Dopamine ↓ DOPAC and HVA | [105, 106, 107, 108] |
6-hydroxydopamine | ↓ Working memory; ↑ locomotion; ↑ Exploratory behavior | ↓ Dopamine ↑ Dopamine receptor 4 ↓ Serotonin transporter binding in striatum | [109, 110, 111] |
Neonatal anoxia | ↑ Locomotion; ↑ exploratory behavior; ↓ spatial memory | Transient changes in neurotransmitters ↑ Dopamine turnover ↓ Noraepinephrine and 5-HIAA ↓ CA1 cell density | [112–114] |
Examples of models for ADHD induced by genetic manipulation in susceptibility genes and selective inbreeding and by prenatal insults.
DOPAC = 3,4-Dihydroxyphenylacetic acid; HVA = Homovanillic acid; 5-HIIA = 5-Hydroxyindoleacetic acid.
There is a consensus about the critical role of animal models for the advance and understanding the functioning of brain and brain disorders, as well as for the development of new treatments. However, it is important to use them judiciously and avoid the over interpretations derived for the findings, as it is noticeable that the results obtained on experimental animals are not necessarily confirmed in clinical studies. As it has been shown, there are several approaches to obtain an animal model for studies in psychiatry, but there is still a limitation in reproducing all the conditions involved in the pathophysiology of the disorder, and it is extremely crucial to recognize this limitation. An alternative that has proved to be efficient is to direct the study to a specific symptom domain that can answer at least in part, the significance of these findings to concretely improve the knowledge in PDs, and thereby bring advances in treatment. The crisis of the classification system is evidenced in the diagnostic inflation in psychiatry, which adds complexity to the preclinical research and complicates the modeling of PDs within the available experimental laboratory animals. The recent and alternative approaches as the RDoC to study the brain and behavior are in a relative infancy, but promises bringing new perspectives in how models that can be improved to become indeed helpful to benefit the quality of life of patients with PDs.
This work was supported by the São Paulo Research Foundation (Fundação de Amparo à Pesquisa do Estado de São Paulo) (FAPESP No. 2013/13392-4 and 2017/02413-1 for M.A.F.H) and the National Council of Technological and Scientific Development (Conselho Nacional de Desenvolvimento Científico e Tecnológico - CNPq) (477760/2010-4, 557753/2010-4; 508113/2010-5; 311815/2012-0; 475739/2013-2; 311815/2012-0 and 309337/2016-0 for M.A.F.H). Both João V. Nani and Benjamín Rodríguez receive fellowship from CAPES. This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Brazil - Finance Code 001.
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Aalborg University has Two Satellite Campuses, one in Copenhagen (Aalborg University Copenhagen) and the other in Esbjerg (Aalborg University Esbjerg).\n· He is a member of prestigious IEEE (Institute of Electrical and Electronics Engineers), and IAENG (International Association of Engineers) organizations. \n· He is the chief Editor of the Journal of Software Engineering.\n· He is the member of the Editorial Board of International Journal of Computer Science and Software Technology (IJCSST) and International Journal of Computer Engineering and Information Technology. \n· He is also the Editor of Communication in Computer and Information Science CCIS-20 by Springer.\n· Reviewer For Many Conferences\nHe is the lead person in making collaboration agreements between Aalborg University and many universities of Pakistan, for which the MOU’s (Memorandum of Understanding) have been signed.\nProfessor Akbar is working in Academia since 1990, he started his career as a Lab demonstrator/TA at the University of Sussex. After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. 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Extensive knowledge on anatomical and physiological aspects of hair can contribute to understand and heal different hair disorders.",book:{id:"5461",slug:"hair-and-scalp-disorders",title:"Hair and Scalp Disorders",fullTitle:"Hair and Scalp Disorders"},signatures:"Bilgen Erdoğan",authors:[{id:"193661",title:"Dr.",name:"Bilgen",middleName:null,surname:"Erdoğan",slug:"bilgen-erdogan",fullName:"Bilgen Erdoğan"}]},{id:"53947",title:"Infections, Infestations and Neoplasms of the Scalp",slug:"infections-infestations-and-neoplasms-of-the-scalp",totalDownloads:3546,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"This chapter reviews common cutaneous infections, infestations, and neoplasms of the scalp. Infections of the scalp are subdivided into three major groups. The most seen are: (1) Bacterial: Folliculitis, folliculitis decalvans, tufted hair folliculitis and acne keloidalis nuchae. (2) Fungal: Tinea capitis, favus and kerion celsi. (3) Protozoal: Syphilitic alopecia. Pediculosis capitis is the most common worldwide infestation of the scalp. The neoplasms of the scalp are large group of different diseases due to arising different origin. In the following section, trichilemmal cyst, proliferating trichilemmal cyst, nevus sebaceous and cylindroma are discussed in detail.",book:{id:"5461",slug:"hair-and-scalp-disorders",title:"Hair and Scalp Disorders",fullTitle:"Hair and Scalp Disorders"},signatures:"Filiz Canpolat",authors:[{id:"191617",title:"Associate Prof.",name:"Filiz",middleName:null,surname:"Canpolat",slug:"filiz-canpolat",fullName:"Filiz Canpolat"}]},{id:"54988",title:"Pathogenic Role of Cytokines and Effect of Their Inhibition in Psoriasis",slug:"pathogenic-role-of-cytokines-and-effect-of-their-inhibition-in-psoriasis",totalDownloads:2350,totalCrossrefCites:1,totalDimensionsCites:6,abstract:"The pathogenesis of psoriasis is complex, and cytokines play an important role in mediating cell-cell interactions that result in abnormal structures and functions of many cell types in psoriasis, such as abnormal proliferation and differentiation of keratinocytes, abnormal proliferation of blood vessels, stimulation of immune cells, and driving abnormal immune reactions. In this chapter, we summarize the roles and functions of inflammatory cytokines that play a crucial role in psoriasis such as tumor necrosis factor (TNF)-α, interleukin (IL)-12/IL-23, and IL-17, as well as their inhibitors that are used to treat psoriasis.",book:{id:"5760",slug:"an-interdisciplinary-approach-to-psoriasis",title:"Psoriasis",fullTitle:"An Interdisciplinary Approach to Psoriasis"},signatures:"Jitlada Meephansan, Urairack Subpayasarn, Mayumi Komine and\nMamitaro Ohtsuki",authors:[{id:"201220",title:"Dr.",name:"Mayumi",middleName:null,surname:"Komine",slug:"mayumi-komine",fullName:"Mayumi Komine"},{id:"205398",title:"Dr.",name:"Jitlada",middleName:null,surname:"Meephansan",slug:"jitlada-meephansan",fullName:"Jitlada Meephansan"},{id:"205400",title:"Prof.",name:"Mamitaro",middleName:null,surname:"Ohtsuki",slug:"mamitaro-ohtsuki",fullName:"Mamitaro Ohtsuki"},{id:"205403",title:"Dr.",name:"Urairack",middleName:null,surname:"Subpayasarn",slug:"urairack-subpayasarn",fullName:"Urairack Subpayasarn"}]},{id:"52034",title:"Occupational Acne",slug:"occupational-acne",totalDownloads:1899,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"Occupational and environmental acne is a dermatological disorder associated with industrial exposure. Polyhalogenated hydrocarbons, coal tar and products, petrol, and other physical, chemical, and environmental agents are suggested to play a role in the etiology of occupational acne. The people working in the field of machine, chemistry, and electrical industry are at high risk. The various occupational acne includes chloracne, coal tar, and oil acne. The most common type in clinic is the comedones, and it is also seen as papule, pustule, and cystic lesions. Histopathological examination shows epidermal hyperplasia, while follicular and sebaceous glands are replaced by keratinized epidermal cells. Topical or oral retinoic acids and oral antibiotics could be used in treatment. The improvement in working conditions, taking preventive measures, and education of the workers could eliminate occupational acne as a problem.",book:{id:"5433",slug:"acne-and-acneiform-eruptions",title:"Acne and Acneiform Eruptions",fullTitle:"Acne and Acneiform Eruptions"},signatures:"Betul Demir and Demet Cicek",authors:[{id:"188909",title:"Dr.",name:"Betul",middleName:null,surname:"Demir",slug:"betul-demir",fullName:"Betul Demir"},{id:"194149",title:"Prof.",name:"Demet",middleName:null,surname:"Cicek",slug:"demet-cicek",fullName:"Demet Cicek"}]},{id:"53525",title:"Trichoscopy and Trichogram",slug:"trichoscopy-and-trichogram",totalDownloads:2633,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"Hair and scalp examination techniques can be classified into three categories: noninvasive methods (clinical history, general examination, photography, hair count, weighing shed hair, pull test, global hair counts, dermoscopy, electron microscopy, laser scanning microscopy, etc.); semi‐invasive methods (the trichogram, unit areatrichogram); and invasive methods (biopsies in cicatritial alopecia). Scalp dermoscopy or trichoscopy is one of thenoninvasive techniques for the evaluation of patients with hair loss that allows for magnified visualization of the hair and scalp skin. It may be performed with a manual dermoscope (10× magnification) or a videodermoscope (up to 1000× magnification). This method is simple, quick, and easy to perform, is well‐accepted by patients, and is useful for monitoring treatment, determining severity of the disease and follow‐up. It is a simple, minimally invasive and rapid technique for measuring hair follicle activity. Trichogram represents a semi‐invasive technique for the evaluation of patients with hair loss that allows the microscopic examination of hairs plucked from the scalp and provides information about the state of the proximal end of the hair shaft and the distal end. The trichogram is a useful complementary tool for clinical evaluation, diagnosis, and the monitoring of treatment response.",book:{id:"5461",slug:"hair-and-scalp-disorders",title:"Hair and Scalp Disorders",fullTitle:"Hair and Scalp Disorders"},signatures:"Melike Kibar",authors:[{id:"189899",title:"Dr.",name:"Melike",middleName:null,surname:"Kibar Ozturk",slug:"melike-kibar-ozturk",fullName:"Melike Kibar Ozturk"}]}],onlineFirstChaptersFilter:{topicId:"175",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"81163",title:"Immunomodulatory Effect of Methotrexate Abruptly Controls Keratinocyte Activation in Psoriasis",slug:"immunomodulatory-effect-of-methotrexate-abruptly-controls-keratinocyte-activation-in-psoriasis",totalDownloads:57,totalDimensionsCites:0,doi:"10.5772/intechopen.102811",abstract:"In psoriatic skin, epidermal keratinocytes (KCs) undergo deregulated inflammatory response that leads to prolonged expression of inflammatory mediators as well as abnormal keratins. Due to immune and genetic factors, KCs get activated and cell balance gets disturbed. This activation is mainly due to deregulated inflammatory response. A vicious cycle of KC-immune response called KC activation cycle leads to psoriasis. In psoriatic skin, epidermal KCs undergo deregulated inflammatory response that leads to prolonged expression of inflammatory mediators as well as abnormal keratins. Methotrexate (MTX) an immunosuppressive agent has been used as a standard drug to treat severe psoriasis. Acanthosis and abnormal terminal differentiation was mainly due to the mutation in epidermal keratins. In turn, disease severity and relapsing of psoriasis are mainly due to the mutation of hyperproliferative keratins. These novel keratin mutations in psoriatic epidermis might be one of the causative factors for psoriasis. MTX strongly regulates the KC activation cycle by deregulated inflammatory markers and maintains normal keratin phenotype on hyperproliferating KC, thereby controlling acanthosis in psoriasis patients.",book:{id:"11087",title:"Psoriasis - New Research",coverURL:"https://cdn.intechopen.com/books/images_new/11087.jpg"},signatures:"Tamilselvi Elango, Anburaj Jeyaraj, Haripriya Dayalan, Pushpa Gnanaraj, Xinghui Li and Xuejun Zhang"},{id:"80572",title:"Th17/IL-17, Immunometabolism and Psoriatic Disease: A Pathological Trifecta",slug:"th17-il-17-immunometabolism-and-psoriatic-disease-a-pathological-trifecta",totalDownloads:30,totalDimensionsCites:0,doi:"10.5772/intechopen.102633",abstract:"The burgeoning arena of immunometabolism provides evidence of how cellular, as well as local (tissue)/systemic metabolic pathways, are playing an important role in controlling immunity and inflammation. An intricate and elaborate network of various metabolic circuits specifically glycolysis, fatty acid oxidation and synthesis and amino acid metabolism precisely generate metabolites that rewire the immune response. Psoriasis is a chronic progressive self-perpetuated “IL-17-centric” inflammatory disease characterized by the co-existence of autoimmune and autoinflammatory pathways. Metabolic responses, governed by oxygen levels, nutrient availability, growth factors, cytokines, AMP/ATP ratios and amino acids, play a pivotal role in programming Th17 cell fate determination. Understanding the intricate interactions and complex interplay of molecular mechanisms responsible for Th17 cell metabolic rewiring, an important determinant of Th17 cell plasticity and heterogeneity, holds the potential to reshape psoriatic therapeutics in ways currently unimagined. This chapter entails with most recent updates on major cellular and systemic metabolic pathways regulating differentiation of Th17 cells as well their cross-talk with intracellular signaling mediators and also sheds light on how dysregulation of these pathways can be responsible for immune impairment and development of psoriatic disease. A better understanding of these metabolic processes could unveil an intriguing leverage point for therapeutic interventions to modulate metabolic programming and Th17 cell responses in this multi-systemic inflammatory disease.",book:{id:"11087",title:"Psoriasis - New Research",coverURL:"https://cdn.intechopen.com/books/images_new/11087.jpg"},signatures:"Seema Chhabra, Smrity Sahu, Keshav Sharma, Maryada Sharma, Lekha Rani, Ranjana Minz and Sunil Dogra"},{id:"80809",title:"Dermoscopic Differential Diagnosis of Psoriasis",slug:"dermoscopic-differential-diagnosis-of-psoriasis",totalDownloads:38,totalDimensionsCites:0,doi:"10.5772/intechopen.103004",abstract:"Psoriasis is a chronic inflammatory skin disease, which is mainly characterized with erythematous indurated plaques with squams such as many other inflammatory skin diseases. Also different clinical subtypes of psoriasis can show distinctive clinical appearances. As an example, inverse psoriasis does not have squams and resemble erythema intertrigo; or erythrodermic variant cannot be distinguished from other erythroderma causes sometimes. From reasons above, differential diagnosis of psoriasis should be done carefully to manage a chronic and long-term treatment required disease appropriately. Histopathologial examination is gold standard technique for certain diagnosis; however, dermoscope is a noninvasive and easily applicable diagnostic tool with high specificity. In this chapter, we discuss dermoscopic differential diagnosis of psoriasis.",book:{id:"11087",title:"Psoriasis - New Research",coverURL:"https://cdn.intechopen.com/books/images_new/11087.jpg"},signatures:"Ece Gokyayla, Tubanur Cetinarslan and Aylin Turel Ermertcan"},{id:"80574",title:"Developing Novel Molecular Targeted Therapeutics for Topical Treatment of Psoriasis",slug:"developing-novel-molecular-targeted-therapeutics-for-topical-treatment-of-psoriasis",totalDownloads:72,totalDimensionsCites:0,doi:"10.5772/intechopen.102725",abstract:"Psoriasis is a chronic inflammatory skin disorder. The prevalence of psoriasis is estimated at approximately 100 million people worldwide. In mild-to-moderate, as well as moderate-to-severe, psoriasis, 70–80% of patients start with topical agents and continue to use them with other active therapies. This group of patients can benefit from topical treatment with minimal systemic exposure. The expression levels of IL-23 and IL-17 are upregulated in psoriatic skin compared with non-lesional skin, associated with psoriasis pathogenesis. The skin epidermal proliferation and psoriasis are caused by overactive Th17 cells, which are promoted and stabilized by the activated IL-23 receptor, forming part of the positive feedback loop. FDA approved biologics in IL-23/IL-17 axis (ustekinumab, guselkumab, risankizumab, tildrakizumab, ixekizumab, secukinumab and brodalumab) demonstrated superior clinical efficacy in the systemic treatment of moderate-to-severe psoriasis, providing the clinical proof of concept of the IL-23/IL-17 axis as a major immune pathway underlying the pathophysiology of psoriasis. However, due to the large size and poor permeability into skin, biologics are not suitable to deliver via topical route. Current topical treatments of mild-to-moderate psoriasis are corticosteroids and vitamin D analogues, which have limited efficacy with significant side effects so that patients must avoid long-term use. This chapter reviews current molecular targeted therapeutics under development for topical treatment of psoriasis.",book:{id:"11087",title:"Psoriasis - New Research",coverURL:"https://cdn.intechopen.com/books/images_new/11087.jpg"},signatures:"Suxing Liu, Di Li and Weikang Tao"},{id:"80408",title:"Immune Markers in Psoriasis",slug:"immune-markers-in-psoriasis",totalDownloads:69,totalDimensionsCites:0,doi:"10.5772/intechopen.102567",abstract:"Psoriasis is a chronic inflammatory skin disorder with high immunological background caused by a complex interplay between an altered immune system, genetic factors, autoantigens, lifestyle, and environmental factors. Extensive literature in recent years highlighted the crucial role played by the immune system in the pathogenesis of this pathology. Although it is unequivocally accepted that psoriasis is a T-cell mediated autoimmune condition, both innate and specific immune cells are highly involved in the pathogenesis of psoriasis. The aberrant interactions between immune cells and resident hyper-proliferative keratinocytes are mediated by immune and non-immune related molecules which lead to amplification of the local immune responses, that maintain the chronic inflammatory status. In this chapter, we will highlight the immune molecules resident in the psoriatic tissue or appending to the blood circulation that can indicate the prognosis of this systemic autoimmune disease. Moreover, we will focus on immune cells resident or circulating ones that can pinpoint the clinical evolution of the psoriatic disease. All these data can be developed in immune markers patterns that aid psoriasis diagnosis and/or future (immune)therapies.",book:{id:"11087",title:"Psoriasis - New Research",coverURL:"https://cdn.intechopen.com/books/images_new/11087.jpg"},signatures:"Mihaela Surcel, Adriana Narcisa Munteanu, Carolina Constantin and Monica Neagu"},{id:"80041",title:"Topical Moisturisers for the Management of Psoriasis Vulgaris",slug:"topical-moisturisers-for-the-management-of-psoriasis-vulgaris",totalDownloads:87,totalDimensionsCites:0,doi:"10.5772/intechopen.101964",abstract:"The aim of this chapter is to provide an overview of basic and tailored topical moisturisers and discuss how and why they form the backbone for the management of psoriasis. Our discussion begins by describing the main characteristics of psoriasis and by indicating how alterations in the skin’s integrity and barrier function contribute to the initial development of psoriasis and subsequent changes in psoriasis phenotype. Next, we address the evolution of topical moisturisers to ever more sophisticated and beneficial products, and describe the key biophysical effects exerted on the psoriatic skin by their active ingredients, as well as the myriad benefits offered by fundamental and specialty ingredients. Furthermore, we delineate how topical moisturiser formulation modalities can help to improve compromised skin barrier function and to alleviate the symptoms of psoriasis, cosmetically and/or therapeutically as well as discuss the associated concerns and challenges encountered along the way.",book:{id:"11087",title:"Psoriasis - New Research",coverURL:"https://cdn.intechopen.com/books/images_new/11087.jpg"},signatures:"Dalibor Mijaljica, Fabrizio Spada and Ian P. Harrison"}],onlineFirstChaptersTotal:8},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:11,numberOfPublishedChapters:91,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:108,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:333,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:11,numberOfPublishedChapters:143,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:124,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:23,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:12,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"13",title:"Veterinary Medicine and Science",doi:"10.5772/intechopen.73681",issn:"2632-0517",scope:"Paralleling similar advances in the medical field, astounding advances occurred in Veterinary Medicine and Science in recent decades. These advances have helped foster better support for animal health, more humane animal production, and a better understanding of the physiology of endangered species to improve the assisted reproductive technologies or the pathogenesis of certain diseases, where animals can be used as models for human diseases (like cancer, degenerative diseases or fertility), and even as a guarantee of public health. Bridging Human, Animal, and Environmental health, the holistic and integrative “One Health” concept intimately associates the developments within those fields, projecting its advancements into practice. This book series aims to tackle various animal-related medicine and sciences fields, providing thematic volumes consisting of high-quality significant research directed to researchers and postgraduates. It aims to give us a glimpse into the new accomplishments in the Veterinary Medicine and Science field. By addressing hot topics in veterinary sciences, we aim to gather authoritative texts within each issue of this series, providing in-depth overviews and analysis for graduates, academics, and practitioners and foreseeing a deeper understanding of the subject. Forthcoming texts, written and edited by experienced researchers from both industry and academia, will also discuss scientific challenges faced today in Veterinary Medicine and Science. 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After almost 32 years of teaching at the University of Trás-os-Montes and Alto Douro, she recently moved to the University of Évora, Department of Veterinary Medicine, where she teaches in the field of Animal Reproduction and Clinics. Her primary research areas include the molecular markers of the endometrial cycle and the embryo–maternal interaction, including oxidative stress and the reproductive physiology and disorders of sexual development, besides the molecular determinants of male and female fertility. She often supervises students preparing their master's or doctoral theses. She is also a frequent referee for various journals.",institutionString:null,institution:{name:"University of Évora",institutionURL:null,country:{name:"Portugal"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:3,paginationItems:[{id:"7",title:"Bioinformatics and Medical Informatics",coverUrl:"https://cdn.intechopen.com/series_topics/covers/7.jpg",isOpenForSubmission:!0,editor:{id:"351533",title:"Dr.",name:"Slawomir",middleName:null,surname:"Wilczynski",slug:"slawomir-wilczynski",fullName:"Slawomir Wilczynski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035U1loQAC/Profile_Picture_1630074514792",biography:"Professor Sławomir Wilczyński, Head of the Chair of Department of Basic Biomedical Sciences, Faculty of Pharmaceutical Sciences, Medical University of Silesia in Katowice, Poland. His research interests are focused on modern imaging methods used in medicine and pharmacy, including in particular hyperspectral imaging, dynamic thermovision analysis, high-resolution ultrasound, as well as other techniques such as EPR, NMR and hemispheric directional reflectance. Author of over 100 scientific works, patents and industrial designs. Expert of the Polish National Center for Research and Development, Member of the Investment Committee in the Bridge Alfa NCBiR program, expert of the Polish Ministry of Funds and Regional Policy, Polish Medical Research Agency. Editor-in-chief of the journal in the field of aesthetic medicine and dermatology - Aesthetica.",institutionString:null,institution:{name:"Medical University of Silesia",institutionURL:null,country:{name:"Poland"}}},editorTwo:null,editorThree:null},{id:"8",title:"Bioinspired Technology and Biomechanics",coverUrl:"https://cdn.intechopen.com/series_topics/covers/8.jpg",isOpenForSubmission:!0,editor:{id:"144937",title:"Prof.",name:"Adriano",middleName:"De Oliveira",surname:"Andrade",slug:"adriano-andrade",fullName:"Adriano Andrade",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRC8QQAW/Profile_Picture_1625219101815",biography:"Dr. Adriano de Oliveira Andrade graduated in Electrical Engineering at the Federal University of Goiás (Brazil) in 1997. He received his MSc and PhD in Biomedical Engineering respectively from the Federal University of Uberlândia (UFU, Brazil) in 2000 and from the University of Reading (UK) in 2005. He completed a one-year Post-Doctoral Fellowship awarded by the DFAIT (Foreign Affairs and International Trade Canada) at the Institute of Biomedical Engineering of the University of New Brunswick (Canada) in 2010. Currently, he is Professor in the Faculty of Electrical Engineering (UFU). He has authored and co-authored more than 200 peer-reviewed publications in Biomedical Engineering. He has been a researcher of The National Council for Scientific and Technological Development (CNPq-Brazil) since 2009. He has served as an ad-hoc consultant for CNPq, CAPES (Coordination for the Improvement of Higher Education Personnel), FINEP (Brazilian Innovation Agency), and other funding bodies on several occasions. He was the Secretary of the Brazilian Society of Biomedical Engineering (SBEB) from 2015 to 2016, President of SBEB (2017-2018) and Vice-President of SBEB (2019-2020). He was the head of the undergraduate program in Biomedical Engineering of the Federal University of Uberlândia (2015 - June/2019) and the head of the Centre for Innovation and Technology Assessment in Health (NIATS/UFU) since 2010. He is the head of the Postgraduate Program in Biomedical Engineering (UFU, July/2019 - to date). He was the secretary of the Parkinson's Disease Association of Uberlândia (2018-2019). Dr. Andrade's primary area of research is focused towards getting information from the neuromuscular system to understand its strategies of organization, adaptation and controlling in the context of motor neuron diseases. 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Working with large volumes of data has given him a good command of big data processing tools and NoSQL databases. He has also been a visiting scholar at the Knowledge Engineering and Discovery Research Institute, Auckland University of Technology.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"314575",title:"Dr.",name:"Jesus",middleName:null,surname:"L. Lobo",slug:"jesus-l.-lobo",fullName:"Jesus L. Lobo",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/314575/images/system/314575.png",biography:"Dr. Jesús López is currently based in Bilbao (Spain) working at TECNALIA as Artificial Intelligence Research Scientist. In most cases, a project idea or a new research line needs to be investigated to see if it is good enough to take into production or to focus on it. That is exactly what he does, diving into Machine Learning algorithms and technologies to help TECNALIA to decide whether something is great in theory or will actually impact on the product or processes of its projects. So, he is expert at framing experiments, developing hypotheses, and proving whether they’re true or not, in order to investigate fundamental problems with a longer time horizon. He is also able to design and develop PoCs and system prototypes in simulation. He has participated in several national and internacional R&D projects.\n\nAs another relevant part of his everyday research work, he usually publishes his findings in reputed scientific refereed journals and international conferences, occasionally acting as reviewer and Programme Commitee member. Concretely, since 2018 he has published 9 JCR (8 Q1) journal papers, 9 conference papers (e.g. ECML PKDD 2021), and he has co-edited a book. He is also active in popular science writing data science stories for reputed blogs (KDNuggets, TowardsDataScience, Naukas). Besides, he has recently embarked on mentoring programmes as mentor, and has also worked as data science trainer.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"103779",title:"Prof.",name:"Yalcin",middleName:null,surname:"Isler",slug:"yalcin-isler",fullName:"Yalcin Isler",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRyQ8QAK/Profile_Picture_1628834958734",biography:"Yalcin Isler (1971 - Burdur / Turkey) received the B.Sc. degree in the Department of Electrical and Electronics Engineering from Anadolu University, Eskisehir, Turkey, in 1993, the M.Sc. degree from the Department of Electronics and Communication Engineering, Suleyman Demirel University, Isparta, Turkey, in 1996, the Ph.D. degree from the Department of Electrical and Electronics Engineering, Dokuz Eylul University, Izmir, Turkey, in 2009, and the Competence of Associate Professorship from the Turkish Interuniversity Council in 2019.\n\nHe was Lecturer at Burdur Vocational School in Suleyman Demirel University (1993-2000, Burdur / Turkey), Software Engineer (2000-2002, Izmir / Turkey), Research Assistant in Bulent Ecevit University (2002-2003, Zonguldak / Turkey), Research Assistant in Dokuz Eylul University (2003-2010, Izmir / Turkey), Assistant Professor at the Department of Electrical and Electronics Engineering in Bulent Ecevit University (2010-2012, Zonguldak / Turkey), Assistant Professor at the Department of Biomedical Engineering in Izmir Katip Celebi University (2012-2019, Izmir / Turkey). He is an Associate Professor at the Department of Biomedical Engineering at Izmir Katip Celebi University, Izmir / Turkey, since 2019. In addition to academics, he has also founded Islerya Medical and Information Technologies Company, Izmir / Turkey, since 2017.\n\nHis main research interests cover biomedical signal processing, pattern recognition, medical device design, programming, and embedded systems. He has many scientific papers and participated in several projects in these study fields. He was an IEEE Student Member (2009-2011) and IEEE Member (2011-2014) and has been IEEE Senior Member since 2014.",institutionString:null,institution:{name:"Izmir Kâtip Çelebi University",country:{name:"Turkey"}}},{id:"339677",title:"Dr.",name:"Mrinmoy",middleName:null,surname:"Roy",slug:"mrinmoy-roy",fullName:"Mrinmoy Roy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/339677/images/16768_n.jpg",biography:"An accomplished Sales & Marketing professional with 12 years of cross-functional experience in well-known organisations such as CIPLA, LUPIN, GLENMARK, ASTRAZENECA across different segment of Sales & Marketing, International Business, Institutional Business, Product Management, Strategic Marketing of HIV, Oncology, Derma, Respiratory, Anti-Diabetic, Nutraceutical & Stomatological Product Portfolio and Generic as well as Chronic Critical Care Portfolio. A First Class MBA in International Business & Strategic Marketing, B.Pharm, D.Pharm, Google Certified Digital Marketing Professional. Qualified PhD Candidate in Operations and Management with special focus on Artificial Intelligence and Machine Learning adoption, analysis and use in Healthcare, Hospital & Pharma Domain. Seasoned with diverse therapy area of Pharmaceutical Sales & Marketing ranging from generating revenue through generating prescriptions, launching new products, and making them big brands with continuous strategy execution at the Physician and Patients level. Moved from Sales to Marketing and Business Development for 3.5 years in South East Asian Market operating from Manila, Philippines. Came back to India and handled and developed Brands such as Gluconorm, Lupisulin, Supracal, Absolut Woman, Hemozink, Fabiflu (For COVID 19), and many more. In my previous assignment I used to develop and execute strategies on Sales & Marketing, Commercialization & Business Development for Institution and Corporate Hospital Business portfolio of Oncology Therapy Area for AstraZeneca Pharma India Ltd. Being a Research Scholar and Student of ‘Operations Research & Management: Artificial Intelligence’ I published several pioneer research papers and book chapters on the same in Internationally reputed journals and Books indexed in Scopus, Springer and Ei Compendex, Google Scholar etc. Currently, I am launching PGDM Pharmaceutical Management Program in IIHMR Bangalore and spearheading the course curriculum and structure of the same. I am interested in Collaboration for Healthcare Innovation, Pharma AI Innovation, Future trend in Marketing and Management with incubation on Healthcare, Healthcare IT startups, AI-ML Modelling and Healthcare Algorithm based training module development. I am also an affiliated member of the Institute of Management Consultant of India, looking forward to Healthcare, Healthcare IT and Innovation, Pharma and Hospital Management Consulting works.",institutionString:null,institution:{name:"Lovely Professional University",country:{name:"India"}}},{id:"1063",title:"Prof.",name:"Constantin",middleName:null,surname:"Volosencu",slug:"constantin-volosencu",fullName:"Constantin Volosencu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/1063/images/system/1063.png",biography:"Prof. Dr. Constantin Voloşencu graduated as an engineer from\nPolitehnica University of Timișoara, Romania, where he also\nobtained a doctorate degree. He is currently a full professor in\nthe Department of Automation and Applied Informatics at the\nsame university. Dr. Voloşencu is the author of ten books, seven\nbook chapters, and more than 160 papers published in journals\nand conference proceedings. He has also edited twelve books and\nhas twenty-seven patents to his name. He is a manager of research grants, editor in\nchief and member of international journal editorial boards, a former plenary speaker, a member of scientific committees, and chair at international conferences. His\nresearch is in the fields of control systems, control of electric drives, fuzzy control\nsystems, neural network applications, fault detection and diagnosis, sensor network\napplications, monitoring of distributed parameter systems, and power ultrasound\napplications. He has developed automation equipment for machine tools, spooling\nmachines, high-power ultrasound processes, and more.",institutionString:'"Politechnica" University Timişoara',institution:null},{id:"221364",title:"Dr.",name:"Eneko",middleName:null,surname:"Osaba",slug:"eneko-osaba",fullName:"Eneko Osaba",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/221364/images/system/221364.jpg",biography:"Dr. Eneko Osaba works at TECNALIA as a senior researcher. He obtained his Ph.D. in Artificial Intelligence in 2015. He has participated in more than twenty-five local and European research projects, and in the publication of more than 130 papers. He has performed several stays at universities in the United Kingdom, Italy, and Malta. Dr. Osaba has served as a program committee member in more than forty international conferences and participated in organizing activities in more than ten international conferences. He is a member of the editorial board of the International Journal of Artificial Intelligence, Data in Brief, and Journal of Advanced Transportation. He is also a guest editor for the Journal of Computational Science, Neurocomputing, Swarm, and Evolutionary Computation and IEEE ITS Magazine.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"275829",title:"Dr.",name:"Esther",middleName:null,surname:"Villar-Rodriguez",slug:"esther-villar-rodriguez",fullName:"Esther Villar-Rodriguez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/275829/images/system/275829.jpg",biography:"Dr. Esther Villar obtained a Ph.D. in Information and Communication Technologies from the University of Alcalá, Spain, in 2015. She obtained a degree in Computer Science from the University of Deusto, Spain, in 2010, and an MSc in Computer Languages and Systems from the National University of Distance Education, Spain, in 2012. Her areas of interest and knowledge include natural language processing (NLP), detection of impersonation in social networks, semantic web, and machine learning. Dr. Esther Villar made several contributions at conferences and publishing in various journals in those fields. Currently, she is working within the OPTIMA (Optimization Modeling & Analytics) business of TECNALIA’s ICT Division as a data scientist in projects related to the prediction and optimization of management and industrial processes (resource planning, energy efficiency, etc).",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"49813",title:"Dr.",name:"Javier",middleName:null,surname:"Del Ser",slug:"javier-del-ser",fullName:"Javier Del Ser",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49813/images/system/49813.png",biography:"Prof. Dr. Javier Del Ser received his first PhD in Telecommunication Engineering (Cum Laude) from the University of Navarra, Spain, in 2006, and a second PhD in Computational Intelligence (Summa Cum Laude) from the University of Alcala, Spain, in 2013. He is currently a principal researcher in data analytics and optimisation at TECNALIA (Spain), a visiting fellow at the Basque Center for Applied Mathematics (BCAM) and a part-time lecturer at the University of the Basque Country (UPV/EHU). His research interests gravitate on the use of descriptive, prescriptive and predictive algorithms for data mining and optimization in a diverse range of application fields such as Energy, Transport, Telecommunications, Health and Industry, among others. In these fields he has published more than 240 articles, co-supervised 8 Ph.D. theses, edited 6 books, coauthored 7 patents and participated/led more than 40 research projects. He is a Senior Member of the IEEE, and a recipient of the Biscay Talent prize for his academic career.",institutionString:"Tecnalia Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"278948",title:"Dr.",name:"Carlos Pedro",middleName:null,surname:"Gonçalves",slug:"carlos-pedro-goncalves",fullName:"Carlos Pedro Gonçalves",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRcmyQAC/Profile_Picture_1564224512145",biography:'Carlos Pedro Gonçalves (PhD) is an Associate Professor at Lusophone University of Humanities and Technologies and a researcher on Complexity Sciences, Quantum Technologies, Artificial Intelligence, Strategic Studies, Studies in Intelligence and Security, FinTech and Financial Risk Modeling. He is also a progammer with programming experience in:\n\nA) Quantum Computing using Qiskit Python module and IBM Quantum Experience Platform, with software developed on the simulation of Quantum Artificial Neural Networks and Quantum Cybersecurity;\n\nB) Artificial Intelligence and Machine learning programming in Python;\n\nC) Artificial Intelligence, Multiagent Systems Modeling and System Dynamics Modeling in Netlogo, with models developed in the areas of Chaos Theory, Econophysics, Artificial Intelligence, Classical and Quantum Complex Systems Science, with the Econophysics models having been cited worldwide and incorporated in PhD programs by different Universities.\n\nReceived an Arctic Code Vault Contributor status by GitHub, due to having developed open source software preserved in the \\"Arctic Code Vault\\" for future generations (https://archiveprogram.github.com/arctic-vault/), with the Strategy Analyzer A.I. module for decision making support (based on his PhD thesis, used in his Classes on Decision Making and in Strategic Intelligence Consulting Activities) and QNeural Python Quantum Neural Network simulator also preserved in the \\"Arctic Code Vault\\", for access to these software modules see: https://github.com/cpgoncalves. He is also a peer reviewer with outsanding review status from Elsevier journals, including Physica A, Neurocomputing and Engineering Applications of Artificial Intelligence. Science CV available at: https://www.cienciavitae.pt//pt/8E1C-A8B3-78C5 and ORCID: https://orcid.org/0000-0002-0298-3974',institutionString:"University of Lisbon",institution:{name:"Universidade Lusófona",country:{name:"Portugal"}}},{id:"310576",title:"Prof.",name:"Erick Giovani",middleName:null,surname:"Sperandio Nascimento",slug:"erick-giovani-sperandio-nascimento",fullName:"Erick Giovani Sperandio Nascimento",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0033Y00002pDKxDQAW/ProfilePicture%202022-06-20%2019%3A57%3A24.788",biography:"Prof. Erick Sperandio is the Lead Researcher and professor of Artificial Intelligence (AI) at SENAI CIMATEC, Bahia, Brazil, also working with Computational Modeling (CM) and HPC. He holds a PhD in Environmental Engineering in the area of Atmospheric Computational Modeling, a Master in Informatics in the field of Computational Intelligence and Graduated in Computer Science from UFES. He currently coordinates, leads and participates in R&D projects in the areas of AI, computational modeling and supercomputing applied to different areas such as Oil and Gas, Health, Advanced Manufacturing, Renewable Energies and Atmospheric Sciences, advising undergraduate, master's and doctoral students. He is the Lead Researcher at SENAI CIMATEC's Reference Center on Artificial Intelligence. In addition, he is a Certified Instructor and University Ambassador of the NVIDIA Deep Learning Institute (DLI) in the areas of Deep Learning, Computer Vision, Natural Language Processing and Recommender Systems, and Principal Investigator of the NVIDIA/CIMATEC AI Joint Lab, the first in Latin America within the NVIDIA AI Technology Center (NVAITC) worldwide program. He also works as a researcher at the Supercomputing Center for Industrial Innovation (CS2i) and at the SENAI Institute of Innovation for Automation (ISI Automação), both from SENAI CIMATEC. He is a member and vice-coordinator of the Basic Board of Scientific-Technological Advice and Evaluation, in the area of Innovation, of the Foundation for Research Support of the State of Bahia (FAPESB). He serves as Technology Transfer Coordinator and one of the Principal Investigators at the National Applied Research Center in Artificial Intelligence (CPA-IA) of SENAI CIMATEC, focusing on Industry, being one of the six CPA-IA in Brazil approved by MCTI / FAPESP / CGI.br. He also participates as one of the representatives of Brazil in the BRICS Innovation Collaboration Working Group on HPC, ICT and AI. He is the coordinator of the Work Group of the Axis 5 - Workforce and Training - of the Brazilian Strategy for Artificial Intelligence (EBIA), and member of the MCTI/EMBRAPII AI Innovation Network Training Committee. He is the coordinator, by SENAI CIMATEC, of the Artificial Intelligence Reference Network of the State of Bahia (REDE BAH.IA). He leads the working group of experts representing Brazil in the Global Partnership on Artificial Intelligence (GPAI), on the theme \"AI and the Pandemic Response\".",institutionString:null,institution:null},{id:"241400",title:"Prof.",name:"Mohammed",middleName:null,surname:"Bsiss",slug:"mohammed-bsiss",fullName:"Mohammed Bsiss",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/241400/images/8062_n.jpg",biography:null,institutionString:null,institution:null},{id:"276128",title:"Dr.",name:"Hira",middleName:null,surname:"Fatima",slug:"hira-fatima",fullName:"Hira Fatima",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/276128/images/14420_n.jpg",biography:"Dr. Hira Fatima\nAssistant Professor\nDepartment of Mathematics\nInstitute of Applied Science\nMangalayatan University, Aligarh\nMobile: no : 8532041179\nhirafatima2014@gmal.com\n\nDr. Hira Fatima has received his Ph.D. degree in pure Mathematics from Aligarh Muslim University, Aligarh India. Currently working as an Assistant Professor in the Department of Mathematics, Institute of Applied Science, Mangalayatan University, Aligarh. She taught so many courses of Mathematics of UG and PG level. Her research Area of Expertise is Functional Analysis & Sequence Spaces. She has been working on Ideal Convergence of double sequence. She has published 17 research papers in National and International Journals including Cogent Mathematics, Filomat, Journal of Intelligent and Fuzzy Systems, Advances in Difference Equations, Journal of Mathematical Analysis, Journal of Mathematical & Computer Science etc. She has also reviewed few research papers for the and international journals. She is a member of Indian Mathematical Society.",institutionString:null,institution:null},{id:"417317",title:"Mrs.",name:"Chiedza",middleName:null,surname:"Elvina Mashiri",slug:"chiedza-elvina-mashiri",fullName:"Chiedza Elvina Mashiri",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Midlands State University",country:{name:"Zimbabwe"}}},{id:"352140",title:"Dr.",name:"Edina",middleName:null,surname:"Chandiwana",slug:"edina-chandiwana",fullName:"Edina Chandiwana",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Midlands State University",country:{name:"Zimbabwe"}}},{id:"342259",title:"B.Sc.",name:"Leonard",middleName:null,surname:"Mushunje",slug:"leonard-mushunje",fullName:"Leonard Mushunje",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Midlands State University",country:{name:"Zimbabwe"}}},{id:"347042",title:"Mr.",name:"Maxwell",middleName:null,surname:"Mashasha",slug:"maxwell-mashasha",fullName:"Maxwell Mashasha",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Midlands State University",country:{name:"Zimbabwe"}}},{id:"2941",title:"Dr.",name:"Alberto J.",middleName:"Jorge",surname:"Rosales-Silva",slug:"alberto-j.-rosales-silva",fullName:"Alberto J. Rosales-Silva",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Instituto Politécnico Nacional",country:{name:"Mexico"}}},{id:"437913",title:"Dr.",name:"Guillermo",middleName:null,surname:"Urriolagoitia-Sosa",slug:"guillermo-urriolagoitia-sosa",fullName:"Guillermo Urriolagoitia-Sosa",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Instituto Politécnico Nacional",country:{name:"Mexico"}}},{id:"435126",title:"Prof.",name:"Joaquim",middleName:null,surname:"José de Castro Ferreira",slug:"joaquim-jose-de-castro-ferreira",fullName:"Joaquim José de Castro Ferreira",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Aveiro",country:{name:"Portugal"}}},{id:"437899",title:"MSc.",name:"Miguel Angel",middleName:null,surname:"Ángel Castillo-Martínez",slug:"miguel-angel-angel-castillo-martinez",fullName:"Miguel Angel Ángel Castillo-Martínez",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Instituto Politécnico Nacional",country:{name:"Mexico"}}},{id:"289955",title:"Dr.",name:"Raja",middleName:null,surname:"Kishor Duggirala",slug:"raja-kishor-duggirala",fullName:"Raja Kishor Duggirala",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Jawaharlal Nehru Technological University, Hyderabad",country:{name:"India"}}}]}},subseries:{item:{id:"10",type:"subseries",title:"Animal Physiology",keywords:"Physiology, Comparative, Evolution, Biomolecules, Organ, Homeostasis, Anatomy, Pathology, Medical, Cell Division, Cell Signaling, Cell Growth, Cell Metabolism, Endocrine, Neuroscience, Cardiovascular, Development, Aging, Development",scope:"Physiology, the scientific study of functions and mechanisms of living systems, is an essential area of research in its own right, but also in relation to medicine and health sciences. The scope of this topic will range from molecular, biochemical, cellular, and physiological processes in all animal species. Work pertaining to the whole organism, organ systems, individual organs and tissues, cells, and biomolecules will be included. Medical, animal, cell, and comparative physiology and allied fields such as anatomy, histology, and pathology with physiology links will be covered in this topic. Physiology research may be linked to development, aging, environment, regular and pathological processes, adaptation and evolution, exercise, or several other factors affecting, or involved with, animal physiology.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/10.jpg",hasOnlineFirst:!1,hasPublishedBooks:!1,annualVolume:11406,editor:{id:"202192",title:"Dr.",name:"Catrin",middleName:null,surname:"Rutland",slug:"catrin-rutland",fullName:"Catrin Rutland",profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",biography:"Catrin Rutland is an Associate Professor of Anatomy and Developmental Genetics at the University of Nottingham, UK. She obtained a BSc from the University of Derby, England, a master’s degree from Technische Universität München, Germany, and a Ph.D. from the University of Nottingham. She undertook a post-doctoral research fellowship in the School of Medicine before accepting tenure in Veterinary Medicine and Science. Dr. Rutland also obtained an MMedSci (Medical Education) and a Postgraduate Certificate in Higher Education (PGCHE). She is the author of more than sixty peer-reviewed journal articles, twelve books/book chapters, and more than 100 research abstracts in cardiovascular biology and oncology. She is a board member of the European Association of Veterinary Anatomists, Fellow of the Anatomical Society, and Senior Fellow of the Higher Education Academy. 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