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Barely three months into the new year and we are happy to announce a monumental milestone reached - 150 million downloads.
\n\nThis achievement solidifies IntechOpen’s place as a pioneer in Open Access publishing and the home to some of the most relevant scientific research available through Open Access.
\n\nWe are so proud to have worked with so many bright minds throughout the years who have helped us spread knowledge through the power of Open Access and we look forward to continuing to support some of the greatest thinkers of our day.
\n\nThank you for making IntechOpen your place of learning, sharing, and discovery, and here’s to 150 million more!
\n\n\n\n\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"3002",leadTitle:null,fullTitle:"Oncogenomics and Cancer Proteomics - Novel Approaches in Biomarkers Discovery and Therapeutic Targets in Cancer",title:"Oncogenomics and Cancer Proteomics",subtitle:"Novel Approaches in Biomarkers Discovery and Therapeutic Targets in Cancer",reviewType:"peer-reviewed",abstract:"Oncogenomics and Cancer Proteomics - Novel Approaches in Biomarkers Discovery and Therapeutic Targets in Cancer presents comprehensive reviews of the most common cancers from bench to bedside applications by an international team of experts. 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Khalid Ijaz",coverURL:"https://cdn.intechopen.com/books/images_new/11006.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"104702",title:"Dr.",name:"Raymond W.",middleName:null,surname:"Nims",slug:"raymond-w.-nims",fullName:"Raymond W. Nims"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}}},ofsBook:{item:{type:"book",id:"10781",leadTitle:null,title:"Cryptococcus and Cryptococcosis",subtitle:null,reviewType:"peer-reviewed",abstract:"
\r\n\tCryptococcosis, caused by the opportunistic yeast Cryptococcus neoformans or Cryptococcus gattii is an important cause of morbidity and mortality in persons immunocompromised by advanced HIV disease. Cryptococcal meningitis is the leading cause of meningitis among adults with sub-Saharan Africa. In addition, C. gattii has been responsible for major outbreaks in North America. There is a growing interest in the epidemiology of cryptococcal infection and disease in HIV-negative individuals, particularly in those with poorly controlled diabetes mellitus and recipients of solid organ transplants.
\r\n\r\n\tThis book intends to provide the reader with a comprehensive overview of the current state-of-the-art in cryptococcosis and its etiologic agent Cryptococcus, featuring original research and up-to-date reviews that focuses on the most important evidence-based developments in this critically important area.
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Fellow of the European Confederation of Medical Mycology and ambassador of the Global Action Fund for Fungal Infections.",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"302145",title:"Dr.",name:"Felix",middleName:null,surname:"Bongomin",slug:"felix-bongomin",fullName:"Felix Bongomin",profilePictureURL:"https://mts.intechopen.com/storage/users/302145/images/system/302145.jpg",biography:"Dr. Felix Bongomin is an internationally recognized expert in clinical mycology and a resident internal medicine physician. His clinical and research interests are in histoplasmosis, aspergillosis, cryptococcosis, and fungal disease epidemiology. He is currently a lecturer in the Department of Medical Microbiology and Immunology, Gulu University School of Medicine, Gulu, Uganda. Dr. Bongomin is actively involved in the teaching of both medical and public health students in various aspects of medical microbiology and immunology. He has authored over 50 papers and book chapters in the areas of fungal diseases. He is a Fellow of the European Confederation of Medical Mycology (FECMM) and an ambassador of the Global Action Fund for Fungal Infections (GAFFI).",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"Gulu University",institutionURL:null,country:{name:"Uganda"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"16",title:"Medicine",slug:"medicine"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"280415",firstName:"Josip",lastName:"Knapic",middleName:null,title:"Mr.",imageUrl:"https://mts.intechopen.com/storage/users/280415/images/8050_n.jpg",email:"josip@intechopen.com",biography:"As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review, to approval and revision, copy-editing and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. 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The main reasons for such a change are a powerful growth of the financial markets, its increasing deregulation and globalization, the growing organizational complexity of these institutions, their corporate and capital partnerships, which increases their overall exposure to risk, as well as the intense development of financial services, which are becoming more accessible to a wider circle of investors.
\n\t\t\tThe development of a comprehensive operational risk management system is the basis for a comprehensive overall company-wide risk management model for any financial institution. The operational risk management system includes the following steps to the analysis of operational risk: the identification of operational risk factors and events, collecting data on operational risk events, the analysis of gathered data and the use of the analysis results in decision making throughout the institution. Historically, the financial institutions’ business environment has the upper hand in the development and implementation of risk management systems, including operational risk management, since risk management was first developed and incorporated. Fortunately, this does not mean that financial institutions hold the exclusive opportunity of using risk management tools to their advantage. As we will show later on, analogue operational risk management systems can also be developed for other industries, such as logistics, where business processes are mainly what operational risk management should focus on; also, high-technology or fast developing industries, such as telecommunications, software, hardware, pharmaceuticals and biotechnology, where the development of new product and services solutions requires substantial financial investments, with patent protection offering substantial rewards and patent lawsuits threatening with substantial financial downfalls.
\n\t\t\tAny operational risk management method allows a company to improve its opportunities in the business environment by identifying potential threats, by identifying potential losses or simply by turning the company’s attention to the processes within that company which in the past have caused or, in turn, experienced the most numerous or most financially burdening operational risk events. The different types of operational risk identification and measurement methods require a different involvement of the company; they also differ in their basic principle – being either qualitative or quantitative, their complexity and comprehensiveness and the width of the application of the data analysis’ results. Among different methods, the use of advanced measurement methods and the use of quantitative methods allow a company to quantify and manage this important type of risk in the widest possible way, but unfortunately, these methods require the most effort by the company – an extensive development, integration and knowledge for such a system to be efficiently used within the company’s overall risk management system.
\n\t\t\tUnfortunately, the quality of any risk management system can only be determined by its use, by testing the quality of gathered data and of forecasts made on the basis of such data. This can be done by comparing the gathered data and forecasts them to actual data arising from continuing operations. Obviously, it is imperative that in such a data gathering operation all levels of business be included; this means that a consensus on all levels of management in the company is necessary and that all levels of operations in the company are aware of, and integrated into, the risk management system.
\n\t\t\tOne of the other problems with such data analysis models, apart from the system setup effort, lies in extreme events, which are rare by nature and extreme by consequences – both quantitatively (e.g. financially) or qualitatively (e.g. loss of reputation). These events may have not yet occurred in the recent history of a financial institution, say in the last 10 years. A logical, albeit erroneous, conclusion one would make based on such data is that extreme events do not happen and will not happen in the future. Such a conclusion may cause the underestimation of minimal capital requirements or capital reserves for financial institutions or the underestimation of risk event provisions in other companies.
\n\t\t\tTherefore, the development of an operational risk management model which takes into consideration and integrates data on extreme events is an important issue for companies with a short historical data background. This is the obvious situation for recently founded companies with a short business history or for companies which only recently developed an operational risk data gathering system. Such companies can be found in most fast developing industries, as well as in changing business environments due to changes in legislation, mode of operation, political or macroeconomic systems. Here, any data gathered in the past can be considered an unreliable base for the use within such a model.
\n\t\t\tIn the following sections of the chapter, we will continue by presenting the different risk management methods which will be followed by proposing, in our opinion, the most suitable method for operational risk management. We will then present an innovative approach in using such a method by adapting it to the poor data environment and showing how to use simulations to obtain additional data for analysis. We will illustrate the use of the method on an example and analyze the results of the model. In conclusion, we will show some possibilities for the integration of the method within the company’s risk management system.
\n\t\tOperational risk can be defined as the risk remaining after eliminating market, credit, interest and exchange risks (Allen & Bali, 2007). The Basel Committee on Banking Supervision defines operational risk as the risk of loss resulting from inadequate or failed internal processes, people and systems or from external events. This definition includes legal risk, but excludes strategic and reputational risk (BIS, 2004; Van Greuning & Bratanovic, 2003). It is in the New Basel Accord (BIS, 2004) that operational risk is given a greater consideration and the methods for its identification, measurement and management are explored. It is also in this document that operational risk is included in the calculation of minimum capital requirements for banks.
\n\t\t\t\tThe New Basel Accord allows financial institutions to choose one of the following proposed methods for the calculation of minimal capital requirements: the Basic Indicator Approach, the Standardized Approach or the Advanced Measurement Approach (AMA). All of the proposed methods can be somewhat modified to measure and manage operational risk, but the AMA is the one most suitable for operational risk events, as it allows the models to be implemented in companies other than financial institutions, i.e. companies which require such models for the calculation of capital adequacy or the calculation of provisions.
\n\t\t\t\tWithin the AMA, a company has the possibility of developing its own specialized operational risk measuring model, with the premises that the model be comprehensive, transparent and systematic. The AMA includes the Internal Measurement Approach, the Scorecard Approach and the Loss Distribution Approach. With the LDA, the company creates a matrix of business processes and possible operational risk events and determines the probability of each combination of events and business processes as well as the severity of the loss. This is the basis for the determination of the loss distribution function of the total loss incurred in a year (or other period). The company then uses the loss distribution to calculate the VaR at a 99.9 % confidence level.
\n\t\t\t\tAccording to Chernobai et al. (2007), the advantages of using the LDA are its high sensitivity, the possibility of integrating both internal and external data into the loss distribution model, as well as expert estimates, and high reliability of results, provided that reliable data is used in the model. Some disadvantages of the method include VaR’s failure to meet the sub-additivity criteria in cases of fat-tailed distributions (Nešlehova et al., 2006), the interdependence and correlation between model input variables, the lack of a diversification effect with extreme event distributions (Embrechts et al. 2002; Ibragimov, 2005), the questionable reliability of high-quantile statistical indicators such as VaR with extreme events (McNeil et al., 2005), as well as the general problem of data gathering and data quality in an environment of scarce and extreme events, which are often well protected information (de Fontnouvelle et al., 2003). Many of these disadvantages can be averted by applying a few modifications to the LDA which will be presented in the next section.
\n\t\t\t\tA key issue in constructing such a model is the identification of the correct loss distribution function for the gathered data. By correctly choosing the loss distribution function a company can calculate the probability and total loss incurred by operational risk events and consequently maintain an adequate level of capital or provisions for operational risk losses. For the purpose of data analysis, the usage of classical statistical functions is quite adequate for data falling within the major part of the loss distribution, but may differ significantly in the tail of the data distribution, especially in the case of heavy-tailed data, where the use of the Extreme Value Theory (EVT) is much more suitable (Moscadelli, 2004). Due to the extreme nature, low frequency and high severity of operational loss events, which can cause significant losses to a financial institution, it is imperative to achieve a good fit in the tail of the distribution function.
\n\t\t\tThe principal method of estimating of the capital charge (or provisions) for operational risk within the LDA is the Value at Risk measure (VaR). From a market risk measure, VaR has become a much more versatile measure of risk (Jorion, 2001; Manganelli & Engle, 2001) thanks to actuarial methods of estimating the loss distribution functions based on historical data.
\n\t\t\t\tVaR is, in a way, a further development of classical derivatives valuation models such as the Black-Scholes model and refers to the volatility of a portfolio
where
Considering that the aggregate operational risk losses are distributed according to an actuarial model,
and the cumulative distribution function (CDF) can be written as:
\n\t\t\t\twhere \n\t\t\t\t\t
Clearly, such a distribution function is non-linear by
Within the actuarial models, the operational risk VaR can be calculated as follows (Chernobai et al., 2007):
\n\t\t\t\tor by using the inverse distribution function:
\n\t\t\t\tBy keeping in mind some specifics when dealing with cumulative operational risk losses data within fat-tailed distribution, where the maximum observed value can significantly affect the cumulative loss
Some of the advantages of using VaR as a risk measure according to Wilson (1998) include the possibility of comparing different types of risk and different subjects, i.e. different financial institutions or, in the case of expanding the method to non-financial sectors, the comparison of other companies in highly competitive industries. It can be used directly as a measure for creating provisions for risk events and the use of VaR can also be applied to certain financial analysis measures, such as ROE or RAROC.
\n\t\t\t\tPotentially, the use of VaR presents also a few problems (Yamai & Yoshiba, 2002). These include the limitation of presenting only the 99.9-percentile loss and all higher losses lying to the right of the 99.9-percentile threshold, creating a potentially non-true picture of potential losses. It also fails to take into consideration the dependencies between risk factors and processes, which can significantly affect the total size of potential operational risk losses, by underestimating or overestimating the projected losses. The use of VaR enables companies to study operational loss data, but it cannot prevent high operational losses in itself. Therefore, the use of VaR must be integrated within an efficient and comprehensive risk management system. Finally, the sub-additivity criteria, which VaR fails to meet, is very important from a methodological point of view, as discussed by Artzner et al. (1999), Chavez-Demoulin et al. (2006) and Embrechts et al. (2002).
\n\t\t\t\tAs an alternative to VaR, some authors are proposing the use of Expected Shortfall (ES) or Conditional Value at Risk (CVaR) (see Chernobai et al., 2007; Embrechts et al., 2008). It can be calculated as:
\n\t\t\t\tCVaR calculates the potential loss in the case an event in the right tail of the distribution beyond VaR should occur. Unlike VaR, which may fail the sub-additivity property, CVaR is a sub-additive measure of risk suitable for use in fat-tailed and extreme event distributions.
\n\t\t\tOperational loss data are typically right-skewed, leptokurtic (i.e. concentrated around the value 0) and fat-tailed on the positive (right) side of the distribution (see Cruz, 2002; Moscadelli, 2004; De Fontnouvelle et al., 2006). The use of EVT methods is therefore recommended.
\n\t\t\t\tThere are two basic analytical methods of the EVT: the
Let
as shown in Figure 1.
\n\t\t\t\tThe conditional excess distribution function above the high threshold u.
\n\t\t\t\t\tEmbrechts et al. (1997) have shown that for high values of
where
\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t
There are several advantages of using the EVT in modeling operational risk event data The advantages and disatvantages of using EVT for high-quantile risk measures are also discussed in Diebold, Schuermann and Stroughair (1998), Embrechts (2000), Aragonés, Blanco and Dowd (2000), Fernandez (2003b), Chavez-Demoulin and Roehl (2004), Emmer, Klüppelberg and Trüstedt (1999) and Bensalah (2000).
Notwithstanding some of the shortcomings of using the EVT (the use of a limited number of observations, which can lead to inaccuracy in parameter estimates; the use of graphic methods; potentially long calculation times in large data samples and complex models; the focus on high-severity events and the potential underestimation of medium- and low-severity events), we feel that the advantages of EVT compared to VaR overweigh its weaknesses in the analysis of operational risk events, especially by applying the modifications of the method as described in the following section.
\n\t\t\tThe operational risk measurement model presented hereby is based on the Loss Distribution Approach (LDA) of the New Basel Accord.
\n\t\t\t\tIt starts out as a bottom-up analysis of business processes, their classification, sorting and grouping into meaningful groups with common characteristics. This allows us to easily observe for operational risk events in practice and it facilitates the identification and further study of these events.
\n\t\t\t\tThe bottom-up approach requires a detailed knowledge of business processes within the company which is where the help of the lowest management levels will provide a very useful feedback. The business processes are then evaluated and the most likely risk factors for the specific business processes are identified and input into the model.
\n\t\t\t\tThe model of
The building elements of the operational risk measurement model.
At this point, one must consider the potential hazard of using experts from within the company as they tend to overemphasize the importance of individual processes and are prone to offering too detailed analyses of their field of operation. The use of sound judgment is definitely called for when setting up the model, as the mapping of business processes and subsequent identification of risk factors should not be too specific in order to find some common ground between processes within the sub-segment and, on the other hand, in order to keep the size of the model manageable and cost-effective.
\n\t\t\t\tThe following steps in implementing the model require several modifications of the LDA, which are illustrated in the following subsection.
\n\t\t\tFirstly, there is the digression from the Basel “operating territory” into the field of non-financial companies that we are proposing and will show later on by example. By selecting a company that operates in the field of high-technology such as software production, we are choosing on average a smaller company than a bank and at the same time an individual organization, thus keeping the model simple while encompassing a full range of business processes and risk factors. We believe that keeping the model manageable in size is one of the most important features that helps it be cost-effective and its results comprehendible, which is why in the case of analyzing a large company we propose that the company first be segmented into few larger divisions (e.g. production, sales, research etc.) and an individual operational risk measurement model be set up for each such division.
\n\t\t\t\tThe high-technology and other fast growing industries and their companies, as well as companies from developing countries, posses a relatively short business history, being due to short-lived stable economic, capital market and legislative environment, or the novelty of their existence in itself, usually ranging from ten to twenty years in the “oldest” new industries or most developed fast-growing countries to none at all other in countries, where the capital market is only a few years old and still in the first phases of development. This is obviously even truer for the individual company. This lack of history, meaning a lack of operational risk event data, causes a significant problem for the consistency and validity of the proposed model, since a large database of consistent quality is the basis of the method (Dell\'Aquila & Embrechts, 2006; Ebnöther et al., 2001). The second proposed modification of the LDA method is aimed to solve this problem. Namely, we propose a widening of the database to include external data from the whole industry and the inclusion of subjective expert’s assessments and estimates on operational risk losses.
\n\t\t\t\tIn collecting expert’s estimations, we adjust for the subjectivity of the estimations by instructing experts to base the estimations on historical data available, we adjust the estimates for differences in the companies’ sizes as well as correcting or eliminating historical data which are biased due to adjustment periods because of restructuring, reorganization, mergers, legislation changes (e.g. tax or capital markets regulation which is known to change often in developing countries) etc. within each company. By adding expert’s estimates of operational risk losses and adjusting historical data, we not only increase the quality and size of the database, creating an adequate base on which to build our model, but we also include the very important expectation or prediction factor of potential losses into the database, which significantly diminishes one of the problems of relying solely on historical data (de Fontnouvelle et al., 2003).
\n\t\t\t\tWithin this modification we propose another similar deviation from the LDA model, the inclusion of potential or opportunity losses of the company, including the ones occurring during the process of detecting a potential (or actual) loss events and eliminating its potential consequences before they reach a significant severity by analyzing its sources or risk factors and limiting their influence by adding several additional internal control mechanisms.
\n\t\t\t\tThirdly, we solve the problem of VaR potentially failing the sub-additivity property of coherent risk measures. Instead of determining a 99.9-confidence level VaR for each of the element of the business process/risk factor matrix and subsequent summation of these VaRs, we use a simulation to obtain the yearly operational risk losses for the entire company. This is then used for a yearly VaR calculation. This way we eliminate not only the sub-additivity problem, but we also eliminate another potential threat: the overestimation of VaR, which can occur by simply adding together several VaR measures, as this method does not take into consideration the diversification effect (Jorion, 2001; Embrechts et al., 2002). The proposed modification also eliminates the task of including correlation parameters into the final VaR estimate (Böcker & Klüppelberg, 2007; Chavez-Demoulin et al., 2006). By simulating total yearly operational risk losses, we obtain a loss distribution function consistent with the sum of the individual business process/risk factor loss distribution functions, while simultaneously simplifying the model and the analysis and reducing calculation time and costs.
\n\t\t\t\tThe use of a simulation is indicated, since discreet events like operational risk loss events can be described by a Poisson process, which can be used for an elegant analysis of the frequencies of event occurrences, including the calculation of event occurrences in longer or shorter time periods and the estimation of event occurrences in two different business processes determined by two separate Poisson functions – the latter due to the sub-additivity property of the Poisson function (Chernobai et al., 2007).
\n\t\t\t\tBy using a Monte Carlo simulation where the event occurrences are determined by a stochastic Poisson process for each business process and with a yearly frequency of
This brings us to the core of the operational risk measurement model, the determination of the probability distribution function (PDF) of the losses. Here we use the EVT methods described in section 2 of the chapter. After successfully processing the data and determining the PDF, we can use the results for the estimation of potential losses using either VaR or CVaR, as described in section 2 of the chapter and, subsequently, determine the capital requirements or provisions that are necessary to protect the company from potential financial losses should an extreme operational risk event ever occur.
\n\t\t\tThe concept of analyzing and the realization of the importance of a company’s business processes have been known for decades, their management has strongly gained importance with Porter’s Value Chain (Porter, 1985). Harmon (2007) and Jeston & Nellis (2008) emphasize the importance of system-oriented process management within the company, keeping in mind that they are inseparably linked within the company and all together contribute to the efficiency of the whole system.
\n\t\t\t\tA thorough business process analysis and business process mapping can identify weak or critical elements in a company’s value chain. By adding the information on risk factors that affect some or all business processes and by setting up additional control and safety mechanisms within the processes, a company can effectively manage those risks and thereby manage its overall business risk.
\n\t\t\t\tThe bottom-up approach that we have chosen for business process mapping in our operational risk measuring model starts with a list of detailed business processes that are being executed throughout the company and are later combined with other processes into process groups with similar characteristics.
\n\t\t\t\tSince operational risk management is already widely spread in financial institutions, especially banks, and we have already stated that the logic behind operational risk management and the use of the proposed model can be generalized and widened to other industrial sectors as well, we will illustrate the construction of the model on a software making company, starting with mapping its business processes For an example of the model use in financial institutions, see Brdar Turk (2009).\n\t\t\t\t\t\t
In mapping the business processes we have also analyzed the organizational structure, the supply, production and sales process and the products of the company. We have identified the following four business process groups and business processes: (1)
The risk factors’ identification was based on the Basel Accord and subsequently modified to the specifics of our example company. We have identified the following seven risk factors: (1)
This whole step can be skipped if there is enough empirical data available for direct use in the model.
\n\t\t\t\t\tBased on available company, industry and competitors’ loss event data, we next estimate the probability distribution type and most important parameters (average, standard deviation) for the size and frequency of loss events in each business segment that are caused by each risk factor (i.e. for 28 process-risk factor combinations).
\n\t\t\t\tWith this data, we use a simulation software package such as GoldSim, AnyLogic or MathLab to generate 1000 repetitions of a business year of our sample software company, thus creating a large data sample of loss event data. The sum of all loss events within one business year creates a composite Poisson distribution
The generated (or gathered) data are first analyzed with elementary statistical methods, as shown in the example below.
\n\t\t\t\tHistogram of loss event severity (shown in EUR) and frequency from example data.
From the histogram alone the skewed nature and the extended right tail of the loss event data distribution is already visible, which is further confirmed by some descriptive statistics: the mean loss severity is slightly greater than the median, the kurtosis and skewness are less than 1, all indicating a right-side fat-tailed distribution.
\n\t\t\t\tMean (EUR) | \n\t\t\t\t\t\t\t67.647,78 | \n\t\t\t\t\t\t
Median (EUR) | \n\t\t\t\t\t\t\t63.872,13 | \n\t\t\t\t\t\t
Standard Deviation (EUR) | \n\t\t\t\t\t\t\t41.424,74 | \n\t\t\t\t\t\t
Sample Variance | \n\t\t\t\t\t\t\t1.716.008.838,65 | \n\t\t\t\t\t\t
Kurtosis | \n\t\t\t\t\t\t\t0,62 | \n\t\t\t\t\t\t
Skewness | \n\t\t\t\t\t\t\t0,76 | \n\t\t\t\t\t\t
99th percentile (EUR) | \n\t\t\t\t\t\t\t207.005,48 | \n\t\t\t\t\t\t
Descriptive statistics for example data.
Similar analyses can be made for individual business process data or risk factors thus identifying the risk factor that causes the most frequent, smallest or most extreme losses from operational risk. This analysis can also provide the answer to the question which business process experiences the most loss events and which process’ losses differ most significantly from a normal distribution. These must be the point of focus in the subsequent operational risk management activities and when implementing additional safety mechanisms and controls.
\n\t\t\tBy using a statistical software package, such as R, Stata or SPSS, we fist establish that we are indeed dealing with an extreme value distribution and that it is appropriate to use EVT methods for parameter estimation. This is done with graphic methods, such as the mean excess plot, which is defined as the mean of all differences between the values of the data exceeding a high threshold
In the case of a fat-tailed distribution, the mean excess plot looks like a straight upward-sloping line (Chernobai et al., 2007; Cruz, 2002). The mean excess plot in Figure 4 clearly indicates that the example data is heavy-tailed.
\n\t\t\t\tMean excess plot for simulated example data.
We then choose several empirical distributions and estimate the functions’ parameters. Among available distributions in EVT we have chosen the most commonly used and tested distributions (see Cruz, 2002; Moscadelli, 2004; Ebnöther et al., 2001; Chapelle et al., 2005): the Generalized Pareto distribution (GPD), Generalized Extreme Value distribution (GEV), the Gumbel and the Weibull distribution. GPD and GEV have been most frequently determined as fitting to extreme losses in financial institutions. Additionally, the Gumbel distribution is a special case of GEV with 0 as the shape parameter, making it easier to determine other function parameters. Both Gumbel’s and Weibul’s are thin-tailed distributions, which consequently results in underestimating extreme losses in the right tail of the distribution.
\n\t\t\t\tAs noted before, we have chosen to analyze the data in the distribution’s right tail and according to EVT, we have chosen the POT method for parameter estimation. The first step is the selection of the high threshold
Additionally, we can use the plot of the shape parameter
Hill plot and Shape estimator plot for example data
In our example data, the Hill plot does not stabilize significantly at any threshold value, whereas the
For the estimation of the GPD parameters we have chosen the maximum likelihood estimate method (MLE) The use of the method in the distribution’s tail is shown by Nylund (2001).
The parameters of all fitted distributions are shown in Table 2.
\n\t\t\t\tDistribution parameter | \n\t\t\t\t\t\t\tParameter value | \n\t\t\t\t\t\t\tStandard error of estimate | \n\t\t\t\t\t\t
GPD | \n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t | \n\t\t\t\t\t\t |
\n\t\t\t\t\t\t\t | 26 . 370 ,00 | \n\t\t\t\t\t\t\t2 . 752 , 17 | \n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t | -0,081 | \n\t\t\t\t\t\t\t0,08 5 | \n\t\t\t\t\t\t
u ( high threshold ) | \n\t\t\t\t\t\t\t150.000 ,00 | \n\t\t\t\t\t\t\t\n\t\t\t\t\t\t |
n u ( number of values above u ) | \n\t\t\t\t\t\t\t136 | \n\t\t\t\t\t\t\t\n\t\t\t\t\t\t |
f <u ( density of data below u ) | \n\t\t\t\t\t\t\t0,861 | \n\t\t\t\t\t\t\t\n\t\t\t\t\t\t |
GEV | \n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t | \n\t\t\t\t\t\t |
\n\t\t\t\t\t\t\t | 94 . 296,74 | \n\t\t\t\t\t\t\t1.031,12 | \n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t | 34 . 047,64 | \n\t\t\t\t\t\t\t940,28 | \n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t | -0,118 | \n\t\t\t\t\t\t\t0,0190 | \n\t\t\t\t\t\t
Gumbel | \n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t | \n\t\t\t\t\t\t |
\n\t\t\t\t\t\t\t | 93 . 463,22 | \n\t\t\t\t\t\t\t1.816,19 | \n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t | 32 . 427,01 | \n\t\t\t\t\t\t\t1.048,58 | \n\t\t\t\t\t\t
Weibull | \n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t | \n\t\t\t\t\t\t |
\n\t\t\t\t\t\t\t | 3,16 | \n\t\t\t\t\t\t\t0,0712 | \n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t | 12 . 387,20 | \n\t\t\t\t\t\t\t878,03 | \n\t\t\t\t\t\t
Distribution parameters estimated from example data
It is important to test for goodness-of-fit for all fitted distributions in order to maximize the analytical power of the model and its potential use in risk management and extreme event prediction. The most common is the use of the quantile-quantile (QQ) plot which shows the empirical distribution quantile vs. actual data. The fit is adequate if the plot is close to the imaginary 45 diagonal line of the plot. The QQ plot can also be drawn for tail data only, which is important for GEV and GPD goodness-of-fit since they were only fitted to tail data.
\n\t\t\t\tQQ plots for GEV for the whole sample (
The results of the graphic tests are shown in Figure 6. They show an apparent adequate fit for GEV for the whole sample, whereas the fit for the tail is clearly inadequate. The plots in Figure 7 show an inadequate fit to Weibul and Gumbel distributions as well. The GPD QQ plot (Figure 8) shows an adequate fit.
\n\t\t\t\tQQ plots for Gumbel (
The QQ plot for GPD.
GPD was additionally tested with the GPD density function and its inverse function plots and residual plots showing an adequate fit in the tail as well as no autocorrelation or heteroschedasticity in the residuals (Figure 9), by which we can conclude that the example data are distributed according to the GPD.
\n\t\t\t\tThe goodness of fit can also be determined by using non-parametric methods such as the Pearson’s Chi-square test (see D\'Agostino & Stephens, 1986). There are two important shortcomings of the test: firstly, its dependency on the number of classes
Goodness of fit tests for GPD with estimated parameters
The second group of tests are empirical distribution function (EDF) based tests, which can be used for all distributions and use the vertical shift of the empirical distribution derived from the data compared to the theoretic distributions (see Anderson & Darling, 1952; D\'Agostino & Stephens, 1986; Chernobai et al., 2007). The most commonly used are the Kolmogorov-Smirnov test (KS) and the Anderson-Darling test (AD).
\n\t\t\t\tLet us denote the empirical distribution function as
where
By the probability integration method, we get the following formula for sample data KS test estimation (D\'Agostino in Stephens, 1986):
\n\t\t\t\twhere
The AD test is defined as:
\n\t\t\t\twhereas for sample data we have:
\n\t\t\t\tThe KS test focuses mostly on the middle of the distribution and gives the values in this area a greater weight within the final result, whereas the AD test focuses more on the distribution tails, making it more suitable for fat-tailed distribution goodness-of-fit testing.
\n\t\t\t\t\n\t\t\t\t\t\t\t | GPD | \n\t\t\t\t\t\t\tGEV | \n\t\t\t\t\t\t\tGumbel | \n\t\t\t\t\t\t\tWeibull | \n\t\t\t\t\t\t
2 | \n\t\t\t\t\t\t\t1 7 . 452 [0,18 9] | \n\t\t\t\t\t\t\tdoes not converge | \n\t\t\t\t\t\t\tdoes not converge | \n\t\t\t\t\t\t\tdoes not converge | \n\t\t\t\t\t\t
KS | \n\t\t\t\t\t\t\t0, 854 [0,8 22 ] | \n\t\t\t\t\t\t\t0,027 [0, 398 ] | \n\t\t\t\t\t\t\t0,517 [0,000] | \n\t\t\t\t\t\t\t0,99 9 [0,000] | \n\t\t\t\t\t\t
AD | \n\t\t\t\t\t\t\t48 , 259 [0,9 52 ] | \n\t\t\t\t\t\t\t0,351 [0, 572 ] | \n\t\t\t\t\t\t\t3 , 275 [0,000] | \n\t\t\t\t\t\t\t2,9 89 [0,000] | \n\t\t\t\t\t\t
Goodness-of-fit test results for example data
The results of the KS and AD tests in Table 3 show that GPD is indeed the most suitable distribution for the example data.
\n\t\t\tThe most obvious use of the analysis’ results is the determination of VaR for the company. We can see from Table 1 that the 10th largest loss amounts to 207.005,48 EUR, which is the VaR at a 99% confidence level. This is the actual loss the company may suffer in the 1% worst case scenario and should set aside provisions (or capital) of this amount to protect from financial distress should such a loss actually occur.
\n\t\t\t\tTo illustrate the underestimation problem with VaR, we calculated VaR and CVaR from the distribution function fitted to the example data and compared them to the empirical VaR (derived directly from sorted example data).
\n\t\t\t\tCriteria | \n\t\t\t\t\t\t\tValue (EUR) | \n\t\t\t\t\t\t
VaR - empirical data | \n\t\t\t\t\t\t\t207.005,48 | \n\t\t\t\t\t\t
VaR ? from GPD | \n\t\t\t\t\t\t\t215.276,32 | \n\t\t\t\t\t\t
CVaR ? from GPD | \n\t\t\t\t\t\t\t218.358,44 | \n\t\t\t\t\t\t
Value at Risk calculations from empirical data and from fitted GPD
From the results shown in Table 4, the following clearly holds:
\n\t\t\t\twhich suggests that the most suitable criteria in view of non-underestimating potential losses for the assessment of capital adequacy or the creation of provisions for the protection from risk losses, is Conditional Value at Risk.
\n\t\t\t\tThere are other uses for the analysis’ results as well. One can focus on a single business sub-process or segment, identify the contribution of individual risk factors to the loss estimates of that segment and use the results to implement additional risk control and prevention mechanisms, significantly reducing the potential risk losses. Also, in times of increased overall risk due to changes in the organization itself or in the business environment, the company can reassess its risk losses estimates and temporarily increase its capital or provisions.
\n\t\t\tThe analysis and evaluation of the quality of the methods for capital adequacy determination itself (Internal Capital Adequacy Assessment Process - ICAAP) is one of the crucial elements of control and supervision as defined by the Basel Accord’s 2nd Pillar. Its goal is to ensure that banks other financial institutions are providing an adequate capital structure for all the risks that the financial institution is exposed to and that they are constantly monitoring and improving risk management practices.
\n\t\t\t\tThis regulatory mechanism can be adapted in other companies as well, especially where advanced methods for risk management, such as the proposed model, are being used. One of the simplest methods for a model’s evaluation is back testing. It involves comparing predictions and analysis results to subsequently gathered data on loss events by comparing a certain percentile (e.g. 80%) of predicted losses to the actual number of loss events above the percentile threshold.
\n\t\t\t\tNaturally, in risk management, where companies deal with extreme and rare events, this may take significant time (e.g. a decade), but the evaluation of smaller and more frequent losses can be effective as well. The evaluation should be performed periodically and also following any major loss event or major changes in the organization or its business environment. With the discovery of discrepancies between the model’s predictions and actual data, a reevaluation of the input data should be performed, identifying potential new risk factors and eliminating those which may have become irrelevant to the company’s operations, reevaluating the frequency and severity of loss events for each business process / risk factor element of the matrix, the integration of new empirical data into the model. Also, a reevaluation of the model’s fitted theoretical distribution should be performed, as it too may significantly affect the results.
\n\t\t\t\tA reevaluation and redesign of the model is sometimes not necessary, since the integration of new loss event data may significantly adjust the model’s results, making it unnecessary to radically change other inputs into the model, since this may be cost-inefficient and may cause the model to become more complex and harder to use and manage.
\n\t\t\tApart from using the proposed model’s results directly as a tool for the determination of capital requirements or provision formation, the model can be integrated into an overall risk management system devised by a company. The creation of an overall risk management system within a company starts with a risk management strategy (Andersen, 1998; Cruz, 2002; Marshall, 2001) which determines the way the company will deal with all the different risks that influence its operations. In this strategy, also called risk management framework or policy, the company must first define the different risks that it is subjected to and subsequently chose a methodology for their management, which includes identification, measurement, recording and analysis of risk event data, reporting, internal controls and risk management system support, the organization of these tasks and a clear definition of employees’ responsibilities and authorizations.
\n\t\t\tThe learning and development processes for risk management activities.
The process of risk management is a continuing learning process as illustrated in Figure 10. The identification and prompt examination of loss events leads to an update of the risk event database and, if necessary, to the update of the underlying risk measurement model, all of which result in an evaluation of the overall risk the company is facing, enabling the management to take corrective and protective measures. An important part of the loop is the reporting process which needs to start in the lowest management levels and continue right to the top management level, where risk awareness is crucial for adequate executive decisions to be taken. A more passive approach to risk management may include loss event recording, analysis and reporting. The next step is a more defensive risk management policy, which includes also a more in-depth risk analysis and corrective measures proposals, which include damage control and additional protective mechanisms and controls within business processes. An active risk management framework, as the final stage of risk management, may include risk event prediction, the development of complex risk causal model, the use of securitization, provisions or insurance and the calculation of risk-adjusted performance measures, such as risk-adjusted return on capital (RAROC), expected value added (EVA) and volatility of profits (Cruz, 2002; Marshall, 2001).
\n\t\tResource depletion and carbon emissions caused by using fossil fuels have increased interest in alternative fuel sources. Utilization of biomass resources is one option to meet the energy requirements for rapid industrialization and population growth with potential environmental and economic benefits. Energy could be derived from a variety of terrestrial, renewable, bio-based feedstocks like sugar-based biomass (e.g. corn, sugarcane, sugarbeet) and lignocellulosic biomass (e.g. wheat straw, corn stover, sugarcane bagasse, forestry residues, switchgrass, energy cane, sorghum, short rotation woody crops). However, production and conversion of these feedstocks could entail risks associated with disruption of the food chain and biodiversity, depletion of freshwater resources and eutrophication.
\nAquatic biomass like microalgae is a promising feedstock with many advantages over terrestrial plants. Its use dates to 1940s [1, 2]. To meet an energy shortage during this period, microalgal biomass was proposed to be used as a source for lipids. Microalgae have higher yield from incident solar energy and higher areal productivity. The photosynthetic efficiency of microalgae (around 3–8%) is substantially higher than that of terrestrial plants (typically 0.5%) due to their simple structure and convenient access to nutrients [3, 4, 5, 108]. Therefore, less land area is required and non-arable, non-productive land could be used for their cultivation. Some species could be cultivated using low quality water such as seawater, brackish water, desalination reject water and wastewater. A microalgae production facility could be operated as a closed loop system by allowing for recycling of water, nutrients and energy from downstream production processes [6, 7, 144]. Microalgae are characterized by high lipid/starch/protein content with a lack of lignin, which makes them well-suited for different conversion technologies [8, 9, 10]. Besides, microalgae cultivation has less potential to interfere with food and feed production. With such versatility, microalgae appear to be a promising biorenewable resource that has the potential to completely replace fossil resources [11]. Research in microalgae biotechnology has increased dramatically since 2005 and has been a very active field in recent years, especially to produce biomass and biofuels [12, 110, 111, 117, 118, 136, 143].
\nThough microalgae may demonstrate benefits over terrestrial feedstocks, the major challenges for their production include significant utilization of nutrients, high energy input for harvesting and dewatering, and complex downstream conversion processes for usable fuels like ethanol and biodiesel [6, 8, 100, 109, 131]. An alternative which can potentially decrease the energy footprint could be biogas production through anaerobic digestion [122, 125, 127, 137]. Anaerobic digestion (AD) is a biochemical process that mineralizes organic compounds to biogas through the synergistic and concerted action of microorganisms under anaerobic (O2 free) conditions. Dry biogas is primarily a mixture of methane and carbon dioxide with traces of ammonia, volatile organic compounds and hydrogen sulfide. Methane content of dry biogas usually ranges between 50 and 70% (by volume). Methane has a higher heating value on a mass basis when compared to liquid fuels, such as biodiesel and bioethanol [13, 145]. AD has been recognized as a mature technology to treat organic waste streams and is widely practiced due to its high energy output to input ratio, environmental benefits, as well as for its process simplicity—compared to bioethanol/biodiesel processes [13, 14]. It is suitable for organic feedstock with high moisture content [15] and so can directly be applied to wet algae biomass feedstock with perhaps little dewatering. Besides, no harsh pretreatment is necessary for algal biomass due to the negligible lignin content [14]. The algal biorefinery could be engineered to be resource efficient by recycling phosphorus and nitrogen nutrients in the digestate effluent and carbon dioxide from biogas upgrading processes for microalgae cultivation [13, 14, 16, 17].
\nIn addition to the physical and chemical properties of the fuel as specified by technical standards, the characteristics desired by the stakeholders, distributors and, consumers could also include sustainability indices related to environmental, social and economic performance. Techno-economic analysis (TEA) establishes a capital and operating cost profile to determine the potential economic viability of the production process for realizing its commercial feasibility. It can be an integral tool to direct research during development of specific technology and assist with investment by averting unnecessary expenditures. A number of techno-economic assessments have been completed to evaluate the economic feasibility of biodiesel derived from microalgae [9, 22, 69, 140, 141]. However, there is a lack of techno-economic analysis on anaerobic digestion of microalgae for biogas production, especially full-scale production taking the characteristics of algae species into consideration. In this chapter, the entire production process from algae cultivation to biogas upgrading will be discussed emphasizing the key cost drivers. TEA literature is reviewed for methodology and state of art technologies. An example of TEA was conducted based on the biogas production process from a microalgae/cyanobacteria species
An anaerobic digestion (AD) process can biochemically convert the whole, wet biomass rather than specific components. The emissions and effluents from the process can be captured for reuse of components like carbon dioxide, ammonia, and phosphorus, and therefore has the potential for economic and environmental benefits. The general biochemical steps in the AD process include: (1) hydrolysis: the breakdown of macromolecules like proteins, lipids, polysaccharides into simpler compounds such as amino acids, sugars, fatty acids and glycerol; (2) acidogenesis and acetogenesis: the hydrolyzed molecules are converted to volatile fatty acids, primarily acetate, hydrogen, and carbon dioxide; (3) methanogenesis: methane production from acetate, hydrogen and carbon dioxide. The hydrolysis step plays a crucial role in determining the successful production of methane [37, 145]. The biochemical processes in AD also occur in nature. AD technology is well established and recognized as a robust technology to convert biomass to bioenergy [146].
\nDespite the potential, questions related to the economic feasibility and the net energy output are the main hurdles hampering the development of biogas production from microalgae [14, 18, 19, 20]. For example, due to the specific structure and composition of the microalgae cell wall, the yield of biogas could be low. Pretreatment to disrupt the cell walls could require high energy inputs. The algae productivity could be low and cultivation cost could be high. Thus, the viability of microalgal biogas production may depend on improvements of efficiency and economic performance. Ongoing efforts include developing inexpensive biomass feedstock, maximizing energy return on investment, and minimizing environmental risks. As only a few studies are available in the literature on the economic feasibility of microalgal biogas exploitation [14], the evaluation and analysis of microalgal biogas production cost will be based on conversion efficiency, technological design aspects as well as available cost information.
\nThe production of biogas from microalgae feedstock entails a series of steps starting with algae cultivation. Implementation of each step involves capital and operational expenditures. The key drivers such as algal biomass productivities, harvesting and dewatering techniques, AD designs, biogas utilization options, integration of algal production, and AD with other bioprocesses were addressed. The production cost breakdown was illustrated in a harmonized framework and a dynamic connection between the technological and economic/environmental assessments was established.
\nA photobioreactor is the essential component of an algae cultivation facility. An open raceway pond (ORP) and a closed photobioreactor (PBR) are two major cultivation platforms. These two platforms for algae biomass production have been extensively studied [22, 23, 24, 25, 26, 27, 83, 84, 85, 101]. The main differences are highlighted in Table 1. In addition, the steps from inoculum preparation to obtaining the wet algal paste typically include systems for culture circulation, growth medium supply, air/flue gas supply, culture cooling, culture harvesting, and process monitoring. Heat exchangers, pumps, and a piping network are also required. The location and climate are important factors for algae cultivation.
\n\n | Open raceway | \nClosed bioreactor | \n
---|---|---|
Biomass productivities | \nLow | \nHigh | \n
Harvesting biomass concentration | \nLow | \nHigh | \n
Total capital cost (CAPEX) | \nRelatively low | \nHigh | \n
Total operational cost (OPEX) | \nRelatively low | \nHigh | \n
Reliability (low contamination risk, stable yield) | \nLow | \nHigh | \n
Net energy ratio (energy output/input) | \n>1 | \n>1 in some cases | \n
Area required | \nHigh | \nLow | \n
Process control | \nLow | \nHigh | \n
CO2 loss | \nHigh | \nLow | \n
Water evaporation | \nHigh | \nLow | \n
Photosynthesis efficiency | \nLow | \nHigh | \n
Scale-up | \nEasy | \nDifficult | \n
A comparison of the open raceway and closed bioreactor systems for algae cultivation.
Due to the high methodological variation of TEA in literature, drawing a generic conclusion over the economic feasibility of microalgal cultivation could be impossible. From the technological and economic perspective, the factors presented below are the ones most prominent in the existing literature and identified as important topics in the development of algae fuels.
Algae harvesting and dewatering methods include gravity settling, chemical coagulation, flocculation, filtration, centrifuge, and drying. The economic feasibility and energy consumption are two criteria for assessing the performance of unit operations for harvesting and dewatering methods. It was found that the cost of separation takes 20–30% of the biomass production costs [32, 33]. Gravity settling, chemical coagulation, and flocculation usually concentrate the microalgal slurries to 2–7% while filtration and centrifugation concentrate microalgal slurry to 15–25% of total suspended solids [32]. The suitability of microalgal dewatering methods has been investigated for scalability, species flexibility, and downstream processing efficacy [33, 34, 35, 36]. Dewatering methods reaching high biomass concentrations are usually associated with high energy input and cost. Thus, a combination of dewatering methods such as flocculation followed by filtration is generally considered to be economical due to the increased harvest efficiency. For downstream processing, methods such as flocculation using flocculants comprised of cationic and anionic poly-electrolytes, synthetic polyacrylamide polymers and starch-based polymers can be employed. However, the detrimental effect of these flocculants on the subsequent microbial processes need to be considered. For example, anaerobic digester stability and gas production could be affected by metal contamination. Future work should include replacing chemical coagulants with natural and low-cost organic ones for harvesting algal biomass.
\nThe efficiency of biogas production has been shown to be species-dependent [39]. One crucial factor is the differences in structure of microalgae cell walls. The role of the cell wall in the microbial degradability of algae biomass is highlighted in many investigations [6, 13, 37, 38, 40, 41, 42, 43]. Many microalgae species (e.g.
The capital cost of the anaerobic digester could be reduced by using reactors designed for high OLR and low HRT [37]. The OLRs are typically between 1 and 6 g VS/L/d while the HRT varies between 10 and 30 days [37, 38]. Although high OLR will increase the methane productivity, overloading will decrease the biogas production efficiency due to the accumulation of inhibitors such as ammonia and acids [6, 37, 38]. Also, prolonged HRT could lead to ammonia inhibition due to slow liquid removal rate [41], while a low HRT could cause the washout of the anaerobic bacteria community [6]. Thus, an optimized OLR and HRT should be applied to achieve the expected specific methane yield. Possible solutions could be improving anaerobic digester configurations such as using membrane reactors or upflow anaerobic sludge blanket reactors to decouple the OLR and HRT [37, 119] and on-line control of anaerobic digester operation [124]. These have not been applied for digesting algal biomass. Additional costs for land and infrastructure and energy expenditures for heating the digesters should be included in the economic analysis.
\nAD microorganisms can grow in three temperature regimes: (1) psychrophilic (5–20°C); (2) mesophilic (25–45°C); and (3) thermophilic (45–65°C). The temperature effect on AD has been discussed [13, 37, 41]. The beneficial temperature regime for AD operation is anaerobic digester is species-specific [44, 45]. The rate of methane generation can be enhanced under mesophilic and thermophilic conditions. The increased temperature could improve enzymatic activity for degrading microorganisms, and at the same time, the photosynthesis activity of viable microalgae within the digester could be reduced [13, 37]. However, an increase in temperature beyond the tolerable range of each temperature regime could cause inactivation of the microbes. Thermophilic temperature may cause increased hydrolysis of nitrogenous compounds which may increase ammonia levels and in turn can cause inhibition [6]. For large-scale biogas productions, the energy required for heating may be more than 1/3 of the total energy output in the form of biogas [46]. Thus, the net energy production from algae biogas may still be limited due to the high heat input associated with a low concentration of algae substrates.
\nThe pH needs to be maintained at an appropriate level for efficient conversion of biomass to biogas. The growth of microbes, enzyme activity, and the biogas compositions are influenced by the pH [47]. The optimum pH level depends on each step of AD [41]. Generally, the pH values are maintained between 7 and 8 for single stage anaerobic digesters [13, 41].
\nMicroalgae grown in a saline environment offer a sustainable alternative to other biomass by utilizing non-arable land and seawater. Marine microalgae can usually grow in a salinity range of 35–125 ppt [48]. However, when a highly saline culture is processed in an anaerobic digester, the high salinity could be inhibitory to the AD process. The effects of salinity and concentration of sodium are discussed in previous studies [6, 38]. Adaptation of anaerobic digester microbial consortiums under different saline conditions was investigated by Mottet et al. [121]. In a promising study, methane production was observed from anaerobically digesting
Sulfide is a required micronutrient for anaerobic microorganisms, but high concentrations of sulfide (200 mg/L) could be toxic [6]. For saline microalgal species, the sulfur inhibition may occur due to the presence of oxidized sulfur compounds in saline algae growth medium. Proper inoculum selection for anaerobic digesters could favor the growth of methanogenic bacteria and limit the growth sulfate-reducing bacteria [49].
\nLipids can also be inhibitory to the AD process [6, 18, 50] although lipids have a high theoretical methane potential. Generally, inhibition would occur when lipids concentrations are higher than 30%. In this case, the high-lipid microalgae are suitable for lipid extraction for production of liquid fuels.
\nMicroalgae biomass generally has a higher composition of protein than terrestrial plants [6, 37]. The degradation of protein will cause ammonia accumulation and inhibit the methanogenesis process. The optimum C/N ratio for AD is between 15 and 30 while this C/N ratio for microalgal AD is generally below 10 [13, 38, 41]. Thus, increasing C/N ratio and reducing the ammonia toxicity are important to enhance the biogas yield and productivity from microalgae. Possible solutions to this issue could be; (1) using ammonia-tolerant inoculum generated either by bioaugmentation or by acclimation [37, 38]; (2) using microalgae biomass that was cultivated under nitrogen-limitation [41, 99, 102, 130]; (3) co-digestion with sludge, oil-greases, waste paper and food wastes [13, 41, 54]; and (4) using a two-stage AD for better control of the anaerobic microbial communities [6]. However, these solutions may add more complexity to the system, in which the economic and energetic performance is still clear. For example, the co-substrate needs to be secured for co-digestion; the digester volume and cost may increase due to the loading of the co-substrate; more environmental burdens may be associated with the shipping of biomass, and nitrogen-limitation cultivation may affect microalgae productivity.
\nMany other factors could affect the biogas yield and production of microalgal biomass. For example, the harvesting time influences the composition and biodegradability of algal biomass. Thus, it is essential to harvest algae in the appropriate stage of growth [13]. Storage conditions such as temperature also have an impact on biomass quality like macromolecular distribution and the content of organic compounds. Besides, inoculum to substrate ratio control is instrumental in avoiding inhibition problems such as drop in pH [51].
\nThe overall biogas yields depend on the chemical composition of the algae strains. The target strain should be highly digestible. The volatile solids/ash-free dry weight of microalgae plays a significant role in predicting theoretical biogas production potential, which is a critical factor in determining biogas productivities. Theoretically, the methane yield from different components of microalgae is as follows: lipids—1 L CH4/g VS, proteins—0.85 L CH4/g VS, carbohydrates—0.42 L CH4/g VS at standard conditions. Although the lipids have a high theoretical methane yield in AD, a high lipid content (more than 40%) will produce inhibitory substances such as long chain fatty acids [6]. Thus, for high-lipid content microalgae, lipid removal for biofuels production may be a better solution than biomass sent directly to AD.
\nThe impact of the algae cell wall is another critical factor affecting methane yield. Some species either lack cell wall or have cell walls rich in easily-biodegradable proteins as in
The microalgal strains which have been investigated extensively include
Components | \nSpecies | \n|||
---|---|---|---|---|
Protein % of DW | \n33 | \n65 | \n64 | \n19 | \n
Carbohydrates % of DW | \n35 | \n23 | \n18 | \n45 | \n
Lipids % of DW | \n22 | \n13 | \n10 | \n36 | \n
Approximate compositions of four microalgal species: Scenedesmus sp., Chlamydomonas reinhardtii, Chlorella vulgaris, and Nannochloropsis salina [41].
In published TEA works, the process complexity was often simplified in terms of limited pathways, few choices of economic drivers and implicit assumptions regarding the growth conditions, process modeling factors and financing of the production facility. Existing reviews in anaerobic digestion of microalgae biomass such as Ward et al. [6] focus on the integration of anaerobic digestion into biodiesel refineries. Considering that diesel or ethanol are more valuable products, anaerobic digestion was suggested to treat the residual biomass to improve the economic viability and sustainability of overall microalgae biodiesel/ethanol stages. Global research in various pathways is going on towards the sustainable development of algae biofuels. The following sections will review these works, highlight the variability of methods of estimating microalgal biogas production cost, find the key drivers of cost contributors, pointing out the convergence and difference in published results, and give a view of the whole value chain towards scaling-up and commercialization when performing a techno-economic analysis (TEA).
\nTo achieve an optimal facility design, it is necessary to evaluate the tradeoff resulting from the interactions between technical advances and financing parameters. The technical objectives include maximizing microalgal biomass productivity, maximizing biogas yield via AD of biomass, and process stabilization. The economic objectives are to minimize the production cost and maximize the economic benefits. Figure 1 shows the TEA framework for the sustainability analysis of biogas production from microalgal biomass through anaerobic digestion. The whole biomass processing value chain is determined by the technology framework and progress through experimentally validated process specifics. Economic analysis is based on the process design, which includes the cost assessments and investment analysis. A decision-making platform is built for raw material suppliers, producers and stake holders in an economic perspective. Correspondingly, the economic consequences will direct the research & development of new technologies, which could form a dynamic connection and optimization framework.
\nTEA framework for biogas production from algae biomass.
Environmental TEA (ETEA) extended the TEA framework with an environmental assessment based on a life cycle analysis [70]. The ETEA is based on the technology readiness level, which means the assessments are performed using the available data based on technology maturity. This would avoid a mismatch between the assessment methodology and the technology readiness level. For example, the whole biogas life cycle includes phases from the biomass cultivation to the final usage and end of life. Under current technology maturity, the whole data set is unavailable, which limits the assessments to certain life cycle phases.
\nBiorefinery optimization and full utilization of biomass addressing in the economic viability and environmental sustainability of the production of algae biofuels can be found in [39, 71, 72]. Dutta et al. [72] analyzed the sustainability of microalgae-derived biofuel production by performing a TEA and life-cycle assessment and found that coproducts valorization is more energy efficient than the processes focusing on specific components such as lipids. Biorefineries with coproducts and byproducts could have better utilization of the algal biomass and can increase the revenue, thus show greater possibility of achieving economic feasibility. In microalgae biodiesel and bioethanol productions, anaerobic digestion is usually integrated into the biorefinery to treat the residues for energy and nutrient recovery. Sialve et al. [18] compared the energy recovery ratio for two scenarios: direct AD of the whole algae biomass and AD of residue biomass after lipid extraction. Direct AD of the whole biomass was considered to have a higher energetic recovery when the cell lipid content does not exceed 40%. Also, increased lipids content in microalgae is not generally compensated with increased productivity due to nitrogen limitation. The potential of direct AD of microalgae biomass was addressed in their research, taking into account the energetic recovery and necessary nutrient recycle for large-scale productions. Chia et al. [73] discussed the economic potential of biohydrogen and biogas production in Germany and Spain. Two processes were compared: direct AD of microalgae biomass (DAD) and coupled hydrogen and biogas production (CHB). In the CHB process, hydrogen was first produced by dark fermentation then effluent from hydrogen fermentation was used for biogas production. The CHB was found to have a lower operating cost due to no additional water and nutrients requirements for the bioreactor feed while the DAD process requires algal biomass in combination with other feedstocks. Both cases have production costs 13–16 times higher than the market price for natural gas. A 1/3 higher biogas yield and a 1/2 lower labor cost did not change the economic status of both processes, due to the high cost of fertilizer and building photobioreactors for microalgae cultivation. Milledge and Heaven [74, 129] performed an energy balance of biogas production from microalgae. Their research emphasized a combination of dewatering methods, as well as the efficient exploitation of the heat generated by the combustion of biogas in combined heat and power (CHP) units to show the energetic viability of the whole process.
\nChew et al. [68] assessed the potential of microalgae biorefineries for producing high-value products such as pigments, proteins, lipids, carbohydrates, and vitamins. The high-value products were added to improve the biorefinery economics. Open pond cultivation and medium recycling were mentioned to have better economic performance than other biorefinery structures. Water, land usage and capital cost were challenging for the economic viability of algal biofuels. The high-value products also need to improve aspects such as separations method, energy consumption, and control of product loss. AD was emphasized to recycle a considerable amount of nutrient usage to make microalgal fuels head towards its large-scale production. Several authors [13, 17, 37, 38, 75, 133, 134] synthesized scientific literature on biogas production from algae and suggested integration of the technology with other technologies as well as co-digestion with other substrates for an optimized biorefinery that sustainably produces biogas. Singh and Gu [76] recommended integrated processes that combine algae cultivation and wastewater treatment for methane production, which could offset the higher cost in comparison to methane production from corn and woody biomass.
\nZamalloa et al. [8] evaluated the techno-economic potential of methane production from microalgae. The assessment was carried out using high rate anaerobic digesters (10–20 kg COD/m3/d) and preconcentrated algae biomass from a full-scale open pond. The energy production cost from microalgal biogas was estimated to be 0.087–0.17 euro/kWh with an algae biomass cost of 86–124 euro/tonne. The result was based on a feed-in tariff of 0.133 euro/kWh and a carbon credit of 30 euro/ton of carbon dioxide. This study is one of the limited works that has been done on a comprehensive technological and economic assessment of electrical and thermal energy produced by biogas through AD of microalgae.
\nCollet et al. [77] performed a life-cycle assessment (LCA) of biogas production from the microalgae
The studies surveyed show considerable variability in the calculated fuel cost and identifying the significant cost contributors. The varied results come from different conversion pathways, technical assumptions (productivity, reactor design, process parameters, etc.) and economic factors (interest rate, raw material cost, etc.), diverse environmental and social conditions (consideration of season and location), and validation of sub-process models (lab/pilot plant/commercial scales). Nevertheless, the contributors to the production cost are mainly identified as microalgal strain selection, biomass cultivation and harvesting, AD operating conditions, biogas upgrading methods, waste management, and type of biorefinery. Thomassen et al. [78] evaluated the methodological reason for the wide variation in the results of multiple environmental and economic assessments. They proposed an environmental techno-economic assessment which can help to solve the challenges for a sustainability assessment: framework for methodology, harmonized assumptions, and integration of different dimensions (stages of technological maturity, technological process). This method is based on the dynamic technological process parameters and the same system boundaries for an integrated TEA and LCA.
\nGnansounou and Dauriat [79] investigated TEAs following different types of cost management systems in value engineering, target costing and a combination of value engineering and target costing. Value engineering includes process design via data collection and process flowsheeting. Process simulators such as Aspen Plus enables the evaluation of the whole process chain based on scale up of the pilot plant, state of art technologies and price quotes. For microalgae to biogas technologies, key issues along the process chain include the suitable choice and operation options of the microalgae species, harvesting/dewatering strategies, pretreatment methods, AD configurations, recycling the digestate, and energy integration. Not all the steps are necessary for technologies with simplified processes and high economic potential. Target costing is a market-oriented method, which means a target selling price was set for the cost evaluation based on market and societal values. Following the target price, the target cost of the final product and each step of the supply process will be estimated, which means the cost allowance will play a key role in the process design. Target costing could integrate with value engineering in the cost management activities, so the cost allowance and cost target could be reconciliated. In the case of biogas production, the target costing evaluation seems unfeasible for the whole process due to the weak financial position of the natural gas market [80].
\nReal options analysis framework was employed by Kern et al. [81] for TEA. The model was adapted to accept stochastic price data for energy and agricultural commodities as well as static operating parameters assumptions for the algal biofuel plants. The TEA work was combined with life cycle analysis in a dynamic system—the fluctuations in market prices for energy and agricultural commodities will influence the operation decisions of the biofuels plants and its associated environmental impacts. Areas such as carbon tax, resource shortage and market forces could be investigated for their impact on biofuel plant design and operations in a dynamic system in the future. This gives the stake holders and suppliers more flexibility in making decisions.
\nThe limitations of TEA include the potential competition for resources. For example, the microalgae biomass could have non-energy applications and has the potential for producing high value products besides biofuels. Then the biomass cost for the process will be influenced not only by the biomass production activities but also the market price which is determined by both the suppliers and purchase competitors.
\nThe sustainability of biogas production from microalgae will depend on not only the commercial viability but also environmental improvements such as greenhouse gas emission reduction, lack of direct and indirect impacts on land-use as well as biodiversity and eutrophication. The scope of TEA is limited for the environmental impact assessment, while these impact categories are appropriate for the goals of the overall sustainability analysis. Thus, an ETEA would allow assessing the sustainability of the entire value chain. Besides, TEA is not reflecting social impacts such as social awareness of algal biofuels’ non-food competitive characteristics, rural development, and public recognition.
\nThe microalgae used for this case study is a cyanobacterium,
Results from many experiments [149] conducted in the Bioprocess Engineering Laboratory, Department of Agricultural and Biological Engineering, University of Florida gave an average growth rate of 67.5 mg afdw/L/day (20.25 g afdw/m2/day) for BG0011 cell biomass and an EPS production rate of 52.5 mg afdw/L/day (15.75 g afdw/m2/day), resulting in cell density of 2.7 g/L and EPS concentration of 2.1 g/L. The areal rates were calculated by assuming that the depth of culture was 30 cm, which is typically the case for open ponds. In the laboratory, the cultures were cultivated under air sparging, a constant illumination of 1200 μmol photons m−2 s−1 light and 13 h to 11 h light-dark cycle. Open raceway ponds are generally used for large-scale commercial production of algal biomass [86]. Productivity in industrial-scale raceway ponds is generally lower than in small experimental reactors. In literature, algae biomass productivity performance claims range from 7 to 35 g afdw/m2/day [23, 87, 88, 89] with corresponding net photosynthetic efficiencies from under 1–4%. Among these, for studies involving techno-economic analyses, the baseline productivity assumed was 20 g/m2/day, with an optimistic value of 25–30 g afdw/m2/day, and a conservative value of 15 g afdw/m2/day. In this study, which assumed that BG0011 is cultivated in current large commercial open ponds, an average productivity of 12.4 g afdw/m2/day (corresponding to a net photosynthetic efficiency of under 1%) was used. Similar growth rates were obtained by [148] when the algae was cultivated by air sparging and exposed to a lower light intensity of 122 μmol photons m−2 s−1 light and 13 h to 11 h light-dark cycle. Here, laboratory-scale BG0011 cell biomass growth rate is comparable to algae cell growth rates reported from other studies, however, in the case of BG0011, it also produces EPS. The average mass ratio between EPS and cell biomass is 0.778: 1 and also EPS production is cell-growth associated, so for this study it is assumed that in the commercial system, in addition to BG0011 cells, EPS would be concomitantly produced at 0.778 × 12.4 g afdw/m2/d = 9.6 g afdw/m2/day. The total algae biomass productivity used was 22 g/m2/d. Henceforth, the term “algae biomass” will include both BG0011 cells and EPS.
\nThe scale of algae cultivation in literature for techno-economic analysis ranges from 200 to 700 ktonne afdw/year [22, 27, 72, 89]. In the present study, the scale of algae cultivation was determined based on a hypothetical 20 million gallons per year ethanol plant. The sugar required for such a plant would be 128 ktonnes afdw/year (assuming yield of around 0.42 g ethanol/g sugar, and 1.1 g sugar/g polysaccharide). Assuming this amount of sugar will be supplied in the form of EPS, the scale of the algae cultivation pond would be 293 ktonnes of algal biomass/year, which also includes BG0011 cell biomass. This scale falls into the range of values found in literature for TEA. To meet a production capacity of 293 ktonnes/year at algal biomass productivity of 22 g afdw/m2/day, land area required would be 3660 hectares (approximately 4 × 4 miles). For a sanity check, this cultivation area was compared to land area required to supplying corn grain for a 20 million gallon per year corn-ethanol plant. Based on annual corn grain yield of 7000 kg/ha with starch content of 72% [150], and assuming a conversion of 0.5 kg ethanol/kg of starch, land required would be 23,700 ha. In this case the total above ground biomass productivity of corn, including corn grain, stover and cobs, is 16,700 kg/ha/year [150] whereas for BG0011 it is anticipated to be 80,300 kg/ha/year.
\nThe BG0011 cultivation cost was estimated based on vendor quotes, literature, or engineering estimates. The installed pond capital cost includes civil work, liner, piping, electrical, other pond costs (such as paddlewheels). In addition, pumps for pumping water from ponds to refinery and for refilling the pond and required land also incur significant capital costs. Plastic lined earthen ponds were chosen for its lower cost compared to concrete ponds. Larger pond sizes would enable economically viable algal biomass production [23]. Here, the installed capital cost was estimated based on “dollars/hectare” of growth ponds for simplicity. The installed pond cost was set to be 80,000 $/ha. Literature value ranges from 46,000 $/ha to more than 150,000 $/ha (value adjusted for inflation) due to different liner scenarios (partial or full) and specific design (e.g. with or without equipment to minimize dead zones) [23, 86] which was not included here. A land cost of 3080 $/acre [90] was used for low-value land. The operation cost for algae cultivation such as utilities, chemicals, labor, overheads, maintenance, insurance tax, etc. were estimated using engineering estimates [91]. BG0011 was assumed to be cultivated in seawater or brackish water. The only fertilizer used for BG 0011 cultivation is phosphorus since it uses dinitrogen in air as a nitrogen source, and seawater would supply rest of micronutrients. From laboratory experiments it was determined that the phosphorous requirement of BG001 is 8.9 mg/L [149], so the annual requirement of phosphorous will be 1186.7 tonnes. Here, triple superphosphate (Ca(H2PO4)2 H2O) which contains 24.6% P is used as phosphorous source with a price of 270 $/tonne (Source: World Bank, 2017). The requirement of triple superphosphate is 4945 tonne/year.
\nThe fixed capital investment was assumed to be borrowed at an interest rate of 10% for 20 years. The plant operates 24 h a day and 360 days annually. The prices were adjusted for Year 2017 using Chemical Engineering Plant Cost Index (CEPCI). These assumptions were also used for the analysis of subsequent biogas production, conversion and upgrading processes. The production cost was calculated as follows:
\nHere, the annual capital charges are calculated as follows:
\n* Total capital cost = Total fixed cost + Working capital.
\n* Working capital is 10% of fixed capital.
\nThe anaerobic digester was designed to treat the un-dewatered whole algae culture from the pond. The energy-intensive steps like algae harvesting and dewatering are avoided in this process which is different from most research [8, 22, 23]. The product biogas was analyzed for economic performance in two different applications: biogas purification or electricity production through combined heat and power.
\nThe first step in modeling mass flow rate of reactor outputs and determining energy requirements is to establish the stoichiometry of reactions. The stoichiometry of methane fermentation of algae biomass was developed based on the following assumptions: (1) microbial cells (cyanobacteria and bacteria) can be represented by the empirical formula CH1.8O0.5N0.2 [151]; (2) EPS is pure polysaccharide represented by the empirical formula C6H10O5; (3) algae biomass can be represented by an empirical formula containing the elements C, H, O and N in the mass ratios in which cells and EPS are produced that is 1:1.2; and (4) methane yield from laboratory assays corresponds to complete decomposition of substrate. The empirical formula for algae biomass was CH1.73O0.67N0.1. The stoichiometry for methane formation is written as follows:
\nMethane yield from algae biomass was measured in the laboratory to be 300 ml at STP (g afdw)−1. This corresponds to 0.35 moles of methane (mole algae biomass)−1, which is equal to value of ‘c’ in the above stoichiometry. The other stoichiometric coefficients can now be solved from elemental balances for C, H, O and N. The stoichiometry is
\nIn the anaerobic digester it was assumed that 98% of the algae biomass is converted. Different scenarios (three anaerobic digester types) were investigated to evaluate the economic and energetic performance. A schematic of biorefinery scenarios are shown in Figure 2.
\nSchematic diagram showing biorefinery scenarios.
Case 1. Above ground mesophilic anaerobic digester. In Aspen, the influent to the reactor was 15 ktonne/h. The temperature was maintained at 37°C. It was operated at an HRT of 25 days.
\nCase 2. Above ground low-temperature anaerobic digester. Anaerobic digestion at low temperatures (LTAD) was applied to improve the energy balance. In this scenario the digester is operated in the psychrophilic range (12–20°C) [92, 93, 94]. However, with the same flow rate, the digester volume is larger to achieve a higher HRT for LTAD than mesophilic and thermophilic anaerobic digestion. Here, the temperature of LTAD is set to 20°C with an HRT of 50 days.
\nCase 3. Covered anaerobic lagoon. Covered anaerobic lagoon (CAL) does not require additional energy for the biogas production because no heating or mixing processes are involved. Besides, it is economical to construct and operate. The CAL in this research was 6 meters deep and covers an area of 1.5 hectares based on literature data [95]. The HRT was set to 50 days. The cost includes anaerobic lagoon excavation, cut and fill, lagoon liner, inlet and out structures, lagoon cover, ancillaries, pipework & installation, contingencies, design, engineering, etc. Operating costs including utility usage are minimal.
\nIn all three cases above, the capital cost of anaerobic digester was estimated using vendor quotation or literature values. The operating cost was estimated by Aspen Process Economic Analyzer.
\nSeveral biogas upgrading or purification methods are available such as high-pressure water scrubbing, membrane, pressure swing, gas permeation and chemical scrubbing. High pressure water scrubbing and chemical scrubbing (using amine solutions—MEA) are two of the most commonly used processes.
\nThe MEA scrubbing method uses aqueous monoethanolamine (MEA) for acidic gas removal. The concentration of amine for acidic gas absorption is usually below 30% (by weight). The amine process has two main steps, absorption and stripping [96]. The detailed MEA scrubbing process is shown in Figure 3. Raw biogas goes through a scrubbing column in which MEA is flowing counter-current to biogas. The CO2-rich MEA is collected at the bottom of the scrubbing column and pumped into a stripping column to remove CO2 and regenerate MEA by heating. Similar to MEA scrubbing, high pressure water scrubbing was also employed for biogas upgrading: biogas is fed to the bottom of scrubber after compressing it to 10 bar. At the top of scrubber, pressurized water is fed. CO2-rich water is then transferred to a flash column with a lower pressure of 3 bar to release gases for feed recirculation and minimizing methane loss. Then the CO2-rich water goes through a CO2 desorption process from the water stream by air [97]. Both biogas purifying approaches were simulated in ASPEN Plus to determine the economics of each approach. The technical specification details are shown in Table 3. The table shows high pressure water scrubbing to be a more economical alternative and was chosen for the integrated process.
\nMEA scrubbing for biogas upgrading.
Specification | \nMEA | \nHigh pressure water scrubbing | \n
---|---|---|
Thermodynamic method | \nELECNRTL | \nPSRK | \n
Scrubbing column | \nRadFrac, 15 stages, pressure: 1.2 bar | \nRadFrac, 10 stages, pressure: 10 bar | \n
Stripping column | \nRadFrac, 15 stages, pressure: 8 bar | \nRadFrac, 10 stages, pressure: 1 bar | \n
Make up chemicals | \nWater: 150 kmol/h MAE: 750 kmol/h | \nWater: 11500 kmol/h | \n
Solvent recycle rate | \nMEA: 0.99 | \nWater: 0.95 | \n
Methane loss | \n1% | \n0.3% | \n
Product methane purity | \n95 wt% | \n99.2 wt% | \n
Capacity (raw biogas flow rate) | \n948.5 kmol/h | \n948.5 kmol/h | \n
Capital cost (million $) | \n8.2 | \n12 | \n
Operating cost (million $/year) | \n20 | \n4.6 | \n
Utility cost (million $/year) | \n17 | \n2 | \n
Purification cost ($/kg of methane) | \n0.3 | \n0.09 | \n
Technical and economic aspects of the biogas purifying systems in ASPEN V 8.8.
While the raw biogas can be purified to obtain biomethane, another option is to use the raw biogas to produce heat and power. Steam and electricity can be generated by burning the raw biogas through a combined heat and power (CHP) system. For reference, the CHP system uses General Electric Jenbacher JGS 420 system which is a 1425 kw generator. The total capital cost is $ 1,150,000 (including installation, tax, etc. 2007), which is 807 $/kw. The working capital is 10% of the total capital. The operating cost includes direct operating cost such as operating labor, supervised labor, maintenance and repairs, as well as indirect operating cost such as overhead, taxed, insurances. It is assumed that 40% biogas energy is for electricity, 50% for steam, 10% loss.
\nThe BG0011 cultivation economics analysis details are shown in Table 4. In the literature algae production costs range from 150 to 6000 $/tonne [19, 22, 27, 72, 89, 142], however, the studies vary from assumptions (production scale, chemical prices, plant life, etc.) to differences in technical specification (photobioreactor design, algal species, etc.). Some of the estimates also account costs for dewatering of algae [22, 27]. Thus, it is difficult to make a direct comparison between different studies. Besides, specific assumptions in each study could be based on different social-economic conditions, which makes comparisons more complicated [98].
\nParameters | \nValues | \n
---|---|
Production scale | \n\n |
BG0011 cells production (ktonne/year) | \n165 | \n
BG0011 EPS production (ktonne/year) | \n128 | \n
Capital cost (including fixed, installed and working capital) | \n\n |
Pond (million $) | \n308 | \n
Land (million $) | \n26.6 | \n
Pump (million $) | \n7.85 | \n
Total capital cost (million $) | \n342.45 | \n
Operating cost | \n\n |
Chemicals (P fertilizer: Ca (H2PO4)2 H2O) (million $/year) | \n1.3 | \n
Other operating cost (including utilities, maintenance and repairs, labor etc.) (million $/year) | \n3.26 | \n
BG0011 algae biomass production cost ($/tonne) | \n153 | \n
Algae cultivation economics.
Details of the production cost of renewable natural gas for the three anaerobic digestion scenarios are shown in Table 5. Case 2 contains two scenarios: The size of anaerobic digester in Case 2(a) is two times of that in Case 1. This is because the hydraulic retention time is longer under lower temperature, the volume of digester needs to be larger to keep the same production scale (the inflow rate). The size of anaerobic digester in Case 2(b) is the same as Case 1. Keeping the digester volume same as Case 1, because the temperature is lower, the productivity will be lower as well. Thus Case 2(b) has a lower production scale compared to other cases. The effect of temperature was incorporated by using the empirical relationship that for every 10°C rise in temperature the degradation rate is doubled. As the difference between the temperature for Case 1 and Case 2 is 17°C, it is expected that in Case 1, the digester has a processing capacity twice as much as that of the digester in Case 2b. The main contributor to the production cost of biogas is the biomass cost. Considering a carbon credit of 10 $/tonne of CO2, the production cost of biogas only drops 0.5 $/MMBtu. The results are comparable to Zamalloa et al.’s [8] research (the only paper focusing on the economics of renewable energy through AD, to our best knowledge): 32.2–61.5 $/MMBtu with the algae biomass cost of 115.4–166.4 $/tonne (0.087–0.17 euro/kwh with an algae biomass cost of 86–124 euro/tonne, 2011). The methane yield is 0.012 MMBtu/kg of VS biomass, which is in close agreement to our experimental result 0.0124 MMBtu/kg of VS biomass.
\nItem | \nCase 1 (mesophilic anaerobic digester) | \nCase 2(a) (low-temperature anaerobic digester) | \nCase 2(b) (low-temperature anaerobic digester | \nCase 3 (covered anaerobic lagoon) | \n
---|---|---|---|---|
Biogas production scale (106 MMBtu/year) | \n3.7 | \n3.7 | \n1.85 | \n3.7 | \n
Fixed capital cost of anaerobic digester (million $) | \n67.12 | \n102 | \n67.12 | \n7.5 | \n
Capital cost except anaerobic digester (million $) | \n16.3 | \n16.3 | \n12.3 | \n16.4 (including land: $11400) | \n
Annual capital charges (million $/year) | \n9.8 | \n13.9 | \n9.3 | \n2.8 | \n
Total raw materials (algae biomass) cost (million $/year) | \n44.8 | \n44.8 | \n44.8 | \n44.8 | \n
Other operating (labor, utility, indirect, etc.) cost (million $/year) | \n25.8 | \n7.1 | \n4.4 | \n7.1 | \n
Utility cost (million $/year) | \n21 | \n2.3 | \n1.4 | \n2.3 | \n
Renewable natural gas production cost ($/MMBtu) | \n21.7 | \n17.8 | \n31.6 | \n14.8 | \n
Process and economic assessment for purified biogas production through anaerobic digestion of Cyanothece BG0011 biomass.
On an energy potential basis, 40% of total methane produced per year could support a 50 MW power plant. Current residential electricity price is around 12 cents/kwh, while industrial price is around 7 cents/kwh. As shown in Table 6, the electricity production cost from biogas is 13 cents/kwh. Renewable energy technologies are usually more expensive than fossil fuel technologies. The reasons could be environmental costs associated with fossil fuels that are not paid by the rate payers, mechanical difficulty in bioenergy production, start-up issues and so on. European countries such as Germany and UK governments subsidize the production of renewable energy by introducing feed-in tariffs. These tariffs may be important to make bioenergy industry profitable.
\nItem | \nValue | \n
---|---|
Electricity capacity (million kwh/year) | \n435 | \n
Total capital cost of the CHP system (million $) (including fix capital cost and 10% working capital) | \n52.4 | \n
Capital charges (million $/year) | \n6.2 | \n
Steam credits (million $/year) | \n3.7 | \n
Raw biogas cost (million $/year) | \n47.7 | \n
Other operating cost (million $/year) | \n9.5 | \n
Electricity production cost ($/kwh) | \n0.13 | \n
The economics of biogas—electricity and steam system.
Nutrient (mostly nitrogen and phosphorous) recycling such as utilizing the digestate or wastewater for microalgae cultivation was highlighted in various studies [59, 60, 61, 62, 63, 104, 105, 106, 107, 126, 128, 138, 139]. Recycling the effluent from the anaerobic digester for algae cultivation could mitigate the costs associated with supplying nutrient for algal biomass growth and effluent treatment. Erkelens et al. [59] validated that microalgae
One option to increase algae biomass productivity and its concentration in the culture is to enrich the air with CO2. It has been shown that enriching the air with 1% CO2 increases cell concentration to 3.46 g afdw/L and EPS concentration to 2.91 g afdw/L, giving an algae biomass concentration of at least 6.37 g afdw/L [149], which is 1.33 times more than that used in the case study above. The increased productivity of algae biomass will reduce further the cost for biomass production. The CO2 released from the biogas upgrading process or waste gases from biogas combustion containing CO2 could be recycled to the algae growth ponds for enriching the air. The economic analysis for this scenario was also performed assuming algae biomass concentration is 1.33 times the previous value of 293 ktonne/year. The estimated production cost for
Upgrading biogas by fixation of the CO2 in biogas via photosynthesis by microalgae has been investigated with respect to CO2 removal capability, biomass productivity and O2 desorption minimization [16, 63, 64, 65, 66, 67]. Toledo-Cervantes et al. [16] optimized the biogas upgrading process by studying the influence of the recycling liquid to biogas ratio. The biomethane produced met specification for injection into natural gas grids. However, this technique requires closed photobioreactors. Hydrogen sulfide (H2S) is another contaminant to be removed from the biogas. Hydrogen sulfide removal was realized by the oxidation of H2S to sulfate by sulfur oxidizing bacteria that used the oxygen produced photosynthetically in situ. In this case, the algae-bacteria symbiosis was employed in the photobioreactors [67]. Nutrient recycling and biogas upgrading provides not only the opportunity for AD of microalgal biomass to be cost-effective, but also the potential to reduce the environmental impacts.
\nTo move industrial application of biogas production from microalgal biomass towards commercialization, additional assessment is required regarding large scale operations. These include (1) strain robustness, outdoor productivity, location and seasonal effects, yield from real production systems, and harvesting strategy for algae cultivation (2) for biomass to biogas conversion processes, the conceptual process design needs to take the following factors into consideration: costs associated with digester heating, land, and infrastructure as well as operational parameters such as maintaining pH, temperature, mixing, power consumption, and production of coproducts like fertilizer.
\nThe uncertainty of large-scale algae cultivation is still a challenge which prevents commercialization; process modeling could provide useful information about the performance of microalgae cultivation systems by estimation and optimization of microalgae productivity under different conditions [103]. A growth kinetic model is critical in a process model simulating microalgae cultivation which has a direct impact on downstream conversion processing systems [135] Lee et al. [31] classified the existing kinetic models into three groups: a single limiting substrate (phosphorus, or dissolved CO2 concentration), a physical limiting factor (light intensity or temperature), and multiple factors (e.g. both substrate and light). Based on their study, there was a tradeoff between the accuracy of the model representation and real-world usability. A future modeling framework should consider along with limiting nutrients, integration of light and temperature, and incorporation of species diversity.
\nAD can be integrated to biorefineries which produce high value products from algae such as chemicals for cosmetics, nutraceuticals and pharmaceuticals. This requires diversified business strategies which benchmark the market potential for the total raw materials and alternative products. In the economic perspective, three approaches could be possible for the development of microalgae AD: (1) implementing AD for biogasification of cell debris or waste streams in microalgal based processes such as biodiesel/bioethanol/high-value bioproducts (e.g. PHA)/fuel cell/hydrothermal liquefaction/hydrogen production [68, 120]; (2) investigation of high-value products from intermediate metabolites produced during AD such as carboxylic acids [37]; (3) electricity production from microalgae derived biogas. In previous sections, the cost of electricity from microalgae derived biogas is comparable with market value while cost of the renewable natural gas from microalgae is much higher than the current market value of natural gas.
\nThis chapter reviewed the literature on TEA of biogas production from algae. The key drivers to the overall production cost were identified and possible process improvements to reduce cost were discussed. The need for harmonization of resource, life cycle and techno-economic assessments in the methodology of TEA was highlighted. Modeling efforts, based on well-informed, rigorous engineering-based process models, should be integrated on a baseline framework such that different process technologies, subprocesses and alternative pathways can be directly compared at a system level. TEA model improvements include strategic planning and using reliable input data from simple mass balance calculations to geographically and seasonally specific assessments, as well as risk analysis for large-scale productivity. Nutrient recycling process has the potential to reduce both cost and environmental burdens.
\nThe cultivation of microalgae BG0011 and its economic feasibility as an energy source through anaerobic digestion was evaluated through a techno-economic analysis. The main contribution to the biogas cost is the biomass production cost. The best-case estimate was a biomethane production cost of 14.8 $/MMBtu using covered anaerobic lagoon and high-pressure water scrubbing purification. The cost of electricity production from biogas was estimated to be 13 cents/kwh. Even though these costs are higher than commercial prices in the United States, these are much lower than those costs with production of liquid fuels like ethanol or biodiesel from algae.
\nImproved algal biomass productivities could be essential for lowering the cost of algae-derived biogas. This could be achieved by recycling the CO2 released during biogas upgrading or combustion for algae cultivation. Algal biogas economics could be further improved by marketing the digester sludge as a soil-amendment product, considering that nitrogen in the sludge was fixed from atmospheric dinitrogen.
\nThe authors gratefully acknowledge funding provided by Office of Energy, Florida Department of Agricultural and Consumer Services under contract number 92420 for this project.
\nThe authors declare that there are no potential financial or other interests that could be perceived to influence the outcomes of the research.
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The importance of these compounds in wine is due to their large effect on the organoleptic attributes of wine. Phenolic compounds play a crucial role in the colour as well as mouthfeel properties of wines. UV-visible spectroscopy appears as a suitable technique for the evaluation of phenolic compounds’ properties and content. The ability of the phenolic ring to absorb UV light and the fact that some of the phenolic substances are coloured compounds, i.e. show absorption features in the visible region, make UV-visible spectroscopy a suitable technique to investigate and quantify grape and wine phenolic compounds. A number of analytical techniques are currently used for phenolic quantification. These include both simpler approaches (spectrophotometric determinations) as well as more complex methodologies such liquid chromatography analysis. Moreover, a number of spectroscopy applications have also been recently reported and are becoming popular within the wine industry. This chapter reviews information on the UV-visible spectral properties of phenolic compounds, changes occurring during wine ageing and also discusses the current UV-visible based analytical techniques used for the quantification of phenolic compounds in grapes and wine.",book:{id:"6878",slug:"frontiers-and-new-trends-in-the-science-of-fermented-food-and-beverages",title:"Frontiers and New Trends in the Science of Fermented Food and Beverages",fullTitle:"Frontiers and New Trends in the Science of Fermented Food and Beverages"},signatures:"Jose Luis Aleixandre-Tudo and Wessel du Toit",authors:[{id:"250919",title:"Dr.",name:"Jose Luis",middleName:null,surname:"Aleixandre-Tudo",slug:"jose-luis-aleixandre-tudo",fullName:"Jose Luis Aleixandre-Tudo"},{id:"261223",title:"Prof.",name:"Wessel",middleName:null,surname:"Du Toit",slug:"wessel-du-toit",fullName:"Wessel Du Toit"}]},{id:"38354",doi:"10.5772/48453",title:"Oxygen Scavengers: An Approach on Food Preservation",slug:"oxygen-scavengers-an-approach-on-food-preservation",totalDownloads:16150,totalCrossrefCites:8,totalDimensionsCites:46,abstract:null,book:{id:"1128",slug:"structure-and-function-of-food-engineering",title:"Structure and Function of Food Engineering",fullTitle:"Structure and Function of Food Engineering"},signatures:"Renato Souza Cruz, Geany Peruch Camilloto and Ana Clarissa dos Santos Pires",authors:[{id:"144206",title:"Dr.",name:"Renato",middleName:null,surname:"Cruz",slug:"renato-cruz",fullName:"Renato Cruz"},{id:"144215",title:"Dr.",name:"Ana Clarissa",middleName:null,surname:"Pires",slug:"ana-clarissa-pires",fullName:"Ana Clarissa Pires"},{id:"144219",title:"MSc.",name:"Geany",middleName:null,surname:"Camilloto",slug:"geany-camilloto",fullName:"Geany Camilloto"}]}],mostDownloadedChaptersLast30Days:[{id:"38363",title:"Pulsed Electric Fields for Food Processing Technology",slug:"pulsed-electric-fields-for-food-processing-technology",totalDownloads:29444,totalCrossrefCites:15,totalDimensionsCites:72,abstract:null,book:{id:"1128",slug:"structure-and-function-of-food-engineering",title:"Structure and Function of Food Engineering",fullTitle:"Structure and Function of Food Engineering"},signatures:"Maged E.A. Mohamed and Ayman H. Amer Eissa",authors:[{id:"147638",title:"Dr.",name:"Maged",middleName:"E. A.",surname:"Mohammed",slug:"maged-mohammed",fullName:"Maged Mohammed"}]},{id:"66671",title:"Extraction and Purification of Pectin from Agro-Industrial Wastes",slug:"extraction-and-purification-of-pectin-from-agro-industrial-wastes",totalDownloads:2721,totalCrossrefCites:1,totalDimensionsCites:9,abstract:"With the advent of science and technology, agro-industrial wastes are converted into various value-added products to meet the demands of increasing population. In recent years, natural polymers have evoked tremendous interest due to easy conversion into value-added products. Apart from various natural polymers, pectin occupied a prominent place due to diverse pharmaceutical and therapeutic applications. Excess utilisation of pectin, the gap between production and demand is widening. To fulfil this gap various techniques are adopted for obtaining high yield pectin from various agro-industrial wastes. This chapter will be focusing on extraction and purification of pectin from various agro-industrial wastes, considered as main environmental pollutants.",book:{id:"8504",slug:"pectins-extraction-purification-characterization-and-applications",title:"Pectins",fullTitle:"Pectins - Extraction, Purification, Characterization and Applications"},signatures:"Erumalla Venkatanagaraju, N. Bharathi, Rachiraju Hema Sindhuja, Rajshree Roy Chowdhury and Yarram Sreelekha",authors:null},{id:"69396",title:"Soybean Amino Acids in Health, Genetics, and Evaluation",slug:"soybean-amino-acids-in-health-genetics-and-evaluation",totalDownloads:1383,totalCrossrefCites:0,totalDimensionsCites:6,abstract:"Soybean is an important source of protein and amino acids for humans and livestock because of its well-balanced amino acid profile. This chapter outlines the strengths and weaknesses of soybean as a complete amino acid source as well as the relative importance of individual amino acids. Special attention is paid to the sulfur-containing amino acids, methionine and cysteine. Breeding and genetic engineering efforts are summarized to highlight previous accomplishments in amino acid improvement and potential avenues for future research. Agronomic properties and processing methods that affect amino acid levels in soybean food and feed are also explained. A brief introduction into current amino acid evaluation techniques is provided. By understanding the complexities of amino acids in soybean, protein quality for humans and livestock can be maximized.",book:{id:"6972",slug:"soybean-for-human-consumption-and-animal-feed",title:"Soybean for Human Consumption and Animal Feed",fullTitle:"Soybean for Human Consumption and Animal Feed"},signatures:"William Monte Singer, Bo Zhang, M.A. Rouf Mian and Haibo Huang",authors:[{id:"308970",title:"Mr.",name:"William",middleName:null,surname:"Singer",slug:"william-singer",fullName:"William Singer"},{id:"309005",title:"Dr.",name:"Bo",middleName:null,surname:"Zhang",slug:"bo-zhang",fullName:"Bo Zhang"},{id:"310776",title:"Dr.",name:"M.A. Rouf",middleName:null,surname:"Mian",slug:"m.a.-rouf-mian",fullName:"M.A. Rouf Mian"},{id:"310777",title:"Dr.",name:"Haibo",middleName:null,surname:"Huang",slug:"haibo-huang",fullName:"Haibo Huang"}]},{id:"56975",title:"Metabolic Processes During Seed Germination",slug:"metabolic-processes-during-seed-germination",totalDownloads:6166,totalCrossrefCites:29,totalDimensionsCites:63,abstract:"Seed germination is crucial stage in plant development and can be considered as a determinant for plant productivity. Physiological and biochemical changes followed by morphological changes during germination are strongly related to seedling survival rate and vegetative growth which consequently affect yield and quality. This study is aimed to focus on proceeding of the most vital metabolic processes namely reserve mobilization, phytohormonal regulation, glyoxylate cycle and respiration process under either stressful or non-stressful conditions that may be led to suggest and conduct the more successful experimental improvements. Seed imbibition triggered the activation of various metabolic processes such as synthesis of hydrolytic enzymes which resulted in hydrolysis of reserve food into simple available form for embryo uptake. Abiotic stresses potentially affect seed germination and seedling establishment through various factors, such as a reduction in water availability, changes in the mobilization of stored reserves, hormonal balance alteration and affecting the structural organization of proteins. Recent strategies for improving seed quality involved classical genetic, molecular biology and invigoration treatments known as priming treatments. H2O2 accumulation and associated oxidative damages together with a decline in antioxidant mechanisms can be regarded as a source of stress that may suppress germination. Seed priming was aimed primarily to control seed hydration by lowering external water potential, or shortening the hydration period.",book:{id:"6096",slug:"advances-in-seed-biology",title:"Seed Biology",fullTitle:"Advances in Seed Biology"},signatures:"Awatif S. Ali and Alaaeldin A. Elozeiri",authors:[{id:"207241",title:"Dr.",name:"Awatif",middleName:null,surname:"Ali",slug:"awatif-ali",fullName:"Awatif Ali"}]},{id:"51587",title:"Casein Proteins: Structural and Functional Aspects",slug:"casein-proteins-structural-and-functional-aspects",totalDownloads:4815,totalCrossrefCites:17,totalDimensionsCites:40,abstract:"Mammalian milk is a complex fluid mixture of various proteins, minerals, and lipids, which play an important role in providing nutrition and immunity to the newborn. Casein proteins, which form about 80% of the bovine milk proteins, form large colloidal particles with calcium phosphate to form casein micelles, which for many years have been an important subject of interest. Casein micelles are composed of four main types of proteins: αS1‐casein, αS2‐casein, β‐casein, and k‐casein. These constituent casein proteins lack well‐defined secondary and tertiary structure due to large amount of propyl residues. These micelles are being extensively studied because of their importance in functional behavior of milk and various milk products. However, the exact structure and nature of these casein micelles are still under debate. These different casein proteins possess different functional properties due to their primary amino acid sequence.",book:{id:"5060",slug:"milk-proteins-from-structure-to-biological-properties-and-health-aspects",title:"Milk Proteins",fullTitle:"Milk Proteins - From Structure to Biological Properties and Health Aspects"},signatures:"Mohd Younus Bhat, Tanveer Ali Dar and Laishram Rajendrakumar\nSingh",authors:[{id:"178323",title:"Dr.",name:"Laishram R",middleName:null,surname:"Singh",slug:"laishram-r-singh",fullName:"Laishram R Singh"},{id:"183444",title:"Mr.",name:"Md. Younus",middleName:null,surname:"Bhat",slug:"md.-younus-bhat",fullName:"Md. Younus Bhat"}]}],onlineFirstChaptersFilter:{topicId:"36",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"81975",title:"Self-Sustained Communities: Food Security in Times of Crisis",slug:"self-sustained-communities-food-security-in-times-of-crisis",totalDownloads:11,totalDimensionsCites:0,doi:"10.5772/intechopen.104425",abstract:"The COVID-19 pandemic has caused an increase in the number of poor people around the world and led to the risk of food insecurity on a global scale. Even in Thailand, a country where food production exceeds domestic demand, the COVID-19 pandemic affects food security. The increased unemployment and the consequent loss of income resulting from the pandemics undermine food accessibility and affordability for many people. This chapter addresses the problem of food insecurity in Thailand during and after the COVID-19 crisis. It provides an analysis of the current status of food insecurity and food system resilience in Thailand and suggests solutions. It also proposes the adoption of a “Food Self-Sustained Community (FSSC)” model, which refers to the concept of building food security in a community. By planning and designing in advance, a community can switch its normal form of production seamlessly to a self-sufficiency model that prepares it for future crises, so that the community can produce enough food for all members without relying on sources outside the community.",book:{id:"10897",title:"Food Systems Resilience",coverURL:"https://cdn.intechopen.com/books/images_new/10897.jpg"},signatures:"Kriengsak Chareonwongsak"},{id:"81297",title:"Legumes Cropping and Nitrogen Fixation under Mediterranean Climate: The Case of Montado/Dehesa System",slug:"legumes-cropping-and-nitrogen-fixation-under-mediterranean-climate-the-case-of-montado-dehesa-system",totalDownloads:24,totalDimensionsCites:0,doi:"10.5772/intechopen.104473",abstract:"Climate change contributes to the environmental pressures that the Montado/Dehesa systems are experiencing, leading to an impoverishment of the floristic composition of the understorey. The strongly acidic soils of these systems are associated with nutrient deficiencies, nutritional disorders and the toxicity of metals, especially Mn and Al; these problems are discussed with emphasis on the antagonism between Fe and Mn and the relationship between K concentration and Mg uptake and concentration. The potential for the use of the legume-rhizobia symbiosis to increase biological nitrogen fixation and avenues for research are discussed. The co-colonization of the roots of legumes with arbuscular mycorrhizal (AM) fungi and the effects on P and Mn uptake are discussed. A better understanding of the relationships between soil pH, organic matter content (SOM), microbial community, soil P content and the plant strategies to mobilize it, as well as plant effects on the soil solution concentrations of Mn, is important for the management of these systems. The increase of biological nitrogen fixation in these systems, through the breeding of tolerant cultivars to acidic soils and a stepwise legumes enrichment, alongside soil fertility management, may contribute to increasing biomass production, SOM content and overall ecological plasticity.",book:{id:"10897",title:"Food Systems Resilience",coverURL:"https://cdn.intechopen.com/books/images_new/10897.jpg"},signatures:"Fernando Teixeira"},{id:"81493",title:"Rust Disease Classification Using Deep Learning Based Algorithm: The Case of Wheat",slug:"rust-disease-classification-using-deep-learning-based-algorithm-the-case-of-wheat",totalDownloads:79,totalDimensionsCites:0,doi:"10.5772/intechopen.104426",abstract:"Rusts are plant diseases caused by obligate fungi parasites. They are usually host-specific and cause greater losses of yields in crops, trees, and ornamental plants. Wheat is a staple food crop bearing losses specifically due to three species of rust fungi namely leaf rust (Puccinia triticina), stem rust (Puccinia graminis), and yellow rust (Puccinia striiformis). These diseases are usually inspected manually by a human being but at a large scale, this process is labor-intensive, time-consuming, and prone to human errors. Therefore, there is a need for an effective and efficient system that helps in the identification and classification of these diseases at early stages. In the present study, a deep learning-based CNN (i.e., VGG16) transfer learning model has been utilized for wheat disease classification on the CGIAR image dataset, containing two classes of wheat rust disease (leaf rust and stem rust), and one class of healthy wheat images. The deep learning models produced the best results by tuning the various hyper-parameters such as batch size, number of epochs, and learning rate. The proposed model has reported the best classification accuracy rate of 99.54% on 80 epochs using an initial learning rate from 0.01 and decayed to 0.0001.",book:{id:"10897",title:"Food Systems Resilience",coverURL:"https://cdn.intechopen.com/books/images_new/10897.jpg"},signatures:"Shivani Sood, Harjeet Singh and Suruchi Jindal"},{id:"81235",title:"Global Food System Transformation for Resilience",slug:"global-food-system-transformation-for-resilience",totalDownloads:65,totalDimensionsCites:1,doi:"10.5772/intechopen.102749",abstract:"Our world is incredibly diverse and beautiful, everything we do has an impact on the environment, and our actions are intertwined. Recognizing how our actions affect the Earth on a global scale means, we need to change the way we do things. We must ensure that the value society derives from our actions comes at a low cost to the environment. A sustainable strategy to establish a resilient food system is to ensure that human demand for the Earth’s resources for food is kept within the supply of these resources. While more than 800 million people worldwide suffer from chronic malnutrition, our food systems emit roughly a third of all greenhouse emissions. Also, over 80% of our biodiversity gets lost. Hence, scaling up food system is simply not an option to feed nine to ten billion people by 2050 as we will need to produce more food in the next four decades than all of history’s farmers have harvested in the last eight thousand years. Therefore, rather than upscaling, the global food systems require transformation. Four critical aspects of this transformation include: “Boosting the small; Transforming the Big; Losing Less; and Eating Smarter.” Examining these four areas more deeply, it becomes evident that, while new technology will be critical to the transformation, government involvement, as well as better financial and behavioral change from residents and consumers, will be required. This chapter focuses on these four pillars that make up the global food system transformation for resilience.",book:{id:"10897",title:"Food Systems Resilience",coverURL:"https://cdn.intechopen.com/books/images_new/10897.jpg"},signatures:"Jasper Okoro Godwin Elechi, Ikechukwu U. Nwiyi and Cornelius Smah Adamu"},{id:"80749",title:"Analysis of the Nexus between Coping Strategies and Resilience to Food Insecurity Shocks: The Case of Rural Households in Boricha Woreda, Sidama National Regional State, Ethiopia",slug:"analysis-of-the-nexus-between-coping-strategies-and-resilience-to-food-insecurity-shocks-the-case-of",totalDownloads:67,totalDimensionsCites:1,doi:"10.5772/intechopen.102613",abstract:"This chapter reports on the coping strategies employed by households in the event of food insecurity shocks and the nexus between the types of coping strategies and resilience to food insecurity in one of the food-stressed woreda from Sidama National Regional State, Ethiopia. The households use various consumption-based coping strategies that run from compromising the quality of food-to-food rationing. Repeatedly occurring food shortage has also forced some households to employ resilience erosive coping mechanisms such as selling reproductive assets. Such coping strategies have an important implication on the household’s capacity to cope with the future food insecurity-related shocks, with a statistically significant relationship between the nature of coping strategies utilized in response to previous food insecurity-related shocks and the household’s resilience to upcoming shocks. Coordinating crises management based on humanitarian intervention with households’ livelihood assets protection and resilience strengthening is the major policy implication of this study.",book:{id:"10897",title:"Food Systems Resilience",coverURL:"https://cdn.intechopen.com/books/images_new/10897.jpg"},signatures:"Adane Atara Debessa, Degefa Tolossa and Berhanu Denu"},{id:"80753",title:"Toward Safe Food Systems: Analyses of Mycotoxin Contaminants in Food and Preventive Strategies Thereof for Their Formation and Toxicity",slug:"toward-safe-food-systems-analyses-of-mycotoxin-contaminants-in-food-and-preventive-strategies-thereo",totalDownloads:64,totalDimensionsCites:0,doi:"10.5772/intechopen.101461",abstract:"Mycotoxin contaminants in food pose a threat to human and animal health. These lead to food wastage and threaten food security that is already a serious problem in Africa. In addition, these affect trading and especially affect incomes of rural farmers. The broad impacts of these contaminants require integrated solutions and strategies. It is thus critical to not only develop strategies for analysis of these toxins but also develop removal and preventive strategies of these contaminants to ensure consumer safety and compliance with regulatory standards. Further within the aim of promoting food safety, there is need for operational policy framework and strategy on the management of these contaminants to promote their mitigation. This chapter discusses integrated strategies for monitoring and control of mycotoxin contamination in food matrices to promote their mitigation and build resilient food systems in Africa and thus reinforce efforts to reach sustainable food security.",book:{id:"10897",title:"Food Systems Resilience",coverURL:"https://cdn.intechopen.com/books/images_new/10897.jpg"},signatures:"Dikabo Mogopodi, Mesha Mbisana, Samuel Raditloko, Inonge Chibua and Banyaladzi Paphane"}],onlineFirstChaptersTotal:10},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:32,numberOfPublishedChapters:320,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:133,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:5,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:16,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"7",title:"Biomedical Engineering",doi:"10.5772/intechopen.71985",issn:"2631-5343",scope:"Biomedical Engineering is one of the fastest-growing interdisciplinary branches of science and industry. 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Dr. Koprowski has authored more than a hundred research papers with dozens in impact factor (IF) journals and has authored or co-authored six books. Additionally, he is the author of several national and international patents in the field of biomedical devices and imaging. 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Her focus is on quality, innovation, leadership, and personalised learning. She works primarily at the strategic and policy levels, both nationally and internationally, and with key international organisations. She is committed to promoting and improving OFDL in the context of SDG4 and the future of education. Ossiannilsson has more than 20 years of experience in her current field, but more than 40 years in the education sector. She works as a reviewer and expert for the European Commission and collaborates with the Joint Research Centre for Quality in Open Education. Ossiannilsson also collaborates with ITCILO and ICoBC (International Council on Badges and Credentials). She is a member of the ICDE Board of Directors and has previously served on the boards of EDEN and EUCEN. Ossiannilsson is a quality expert and reviewer for ICDE, EDEN and the EADTU. She chairs the ICDE OER Advocacy Committee and is a member of the ICDE Quality Network. 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Currently, he is a professor of Orthodontics. He holds a Certificate of Advanced Study type A in Technology of Biomaterials used in Dentistry (1995); Certificate of Advanced Study type B in Dento-Facial Orthopaedics (1997) from the Faculty of Dental Surgery, University Denis Diderot-Paris VII, France; Diploma of Advanced Study (DESA) in Biocompatibility of Biomaterials from the Faculty of Medicine and Pharmacy of Casablanca (2002); Certificate of Clinical Occlusodontics from the Faculty of Dentistry of Casablanca (2004); University Diploma of Biostatistics and Perceptual Health Measurement from the Faculty of Medicine and Pharmacy of Casablanca (2011); and a University Diploma of Pedagogy of Odontological Sciences from the Faculty of Dentistry of Casablanca (2013). 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Radiotherapy and Nuclear Medicine Technology has always been my aspiration and my life. As years passed I accumulated a tremendous amount of skills and knowledge in Radiotherapy and Nuclear Medicine, Conventional Radiology, Radiation Protection, Bioinformatics Technology, PACS, Image processing, clinically and lecturing that will enable me to provide a valuable service to the community as a Researcher and Consultant in this field. My method of translating this into day to day in clinical practice is non-exhaustible and my habit of exchanging knowledge and expertise with others in those fields is the code and secret of success.",institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"313277",title:"Dr.",name:"Bartłomiej",middleName:null,surname:"Płaczek",slug:"bartlomiej-placzek",fullName:"Bartłomiej Płaczek",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/313277/images/system/313277.jpg",biography:"Bartłomiej Płaczek, MSc (2002), Ph.D. (2005), Habilitation (2016), is a professor at the University of Silesia, Institute of Computer Science, Poland, and an expert from the National Centre for Research and Development. His research interests include sensor networks, smart sensors, intelligent systems, and image processing with applications in healthcare and medicine. He is the author or co-author of more than seventy papers in peer-reviewed journals and conferences as well as the co-author of several books. He serves as a reviewer for many scientific journals, international conferences, and research foundations. Since 2010, Dr. Placzek has been a reviewer of grants and projects (including EU projects) in the field of information technologies.",institutionString:"University of Silesia",institution:{name:"University of Silesia",country:{name:"Poland"}}},{id:"35000",title:"Prof.",name:"Ulrich H.P",middleName:"H.P.",surname:"Fischer",slug:"ulrich-h.p-fischer",fullName:"Ulrich H.P Fischer",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/35000/images/3052_n.jpg",biography:"Academic and Professional Background\nUlrich H. P. has Diploma and PhD degrees in Physics from the Free University Berlin, Germany. He has been working on research positions in the Heinrich-Hertz-Institute in Germany. Several international research projects has been performed with European partners from France, Netherlands, Norway and the UK. He is currently Professor of Communications Systems at the Harz University of Applied Sciences, Germany.\n\nPublications and Publishing\nHe has edited one book, a special interest book about ‘Optoelectronic Packaging’ (VDE, Berlin, Germany), and has published over 100 papers and is owner of several international patents for WDM over POF key elements.\n\nKey Research and Consulting Interests\nUlrich’s research activity has always been related to Spectroscopy and Optical Communications Technology. Specific current interests include the validation of complex instruments, and the application of VR technology to the development and testing of measurement systems. He has been reviewer for several publications of the Optical Society of America\\'s including Photonics Technology Letters and Applied Optics.\n\nPersonal Interests\nThese include motor cycling in a very relaxed manner and performing martial arts.",institutionString:null,institution:{name:"Charité",country:{name:"Germany"}}},{id:"341622",title:"Ph.D.",name:"Eduardo",middleName:null,surname:"Rojas Alvarez",slug:"eduardo-rojas-alvarez",fullName:"Eduardo Rojas Alvarez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/341622/images/15892_n.jpg",biography:null,institutionString:null,institution:{name:"University of Cuenca",country:{name:"Ecuador"}}},{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/215610/images/system/215610.jpeg",biography:"Muhammad Sarfraz is a professor in the Department of Information Science, Kuwait University. His research interests include computer graphics, computer vision, image processing, machine learning, pattern recognition, soft computing, data science, intelligent systems, information technology, and information systems. Prof. Sarfraz has been a keynote/invited speaker on various platforms around the globe. He has advised various students for their MSc and Ph.D. theses. He has published more than 400 publications as books, journal articles, and conference papers. He is a member of various professional societies and a chair and member of the International Advisory Committees and Organizing Committees of various international conferences. Prof. Sarfraz is also an editor-in-chief and editor of various international journals.",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"32650",title:"Prof.",name:"Lukas",middleName:"Willem",surname:"Snyman",slug:"lukas-snyman",fullName:"Lukas Snyman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/32650/images/4136_n.jpg",biography:"Lukas Willem Snyman received his basic education at primary and high schools in South Africa, Eastern Cape. He enrolled at today's Nelson Metropolitan University and graduated from this university with a BSc in Physics and Mathematics, B.Sc Honors in Physics, MSc in Semiconductor Physics, and a Ph.D. in Semiconductor Physics in 1987. After his studies, he chose an academic career and devoted his energy to the teaching of physics to first, second, and third-year students. After positions as a lecturer at the University of Port Elizabeth, he accepted a position as Associate Professor at the University of Pretoria, South Africa.\r\n\r\nIn 1992, he motivates the concept of 'television and computer-based education” as means to reach large student numbers with only the best of teaching expertise and publishes an article on the concept in the SA Journal of Higher Education of 1993 (and later in 2003). The University of Pretoria subsequently approved a series of test projects on the concept with outreach to Mamelodi and Eerste Rust in 1993. In 1994, the University established a 'Unit for Telematic Education ' as a support section for multiple faculties at the University of Pretoria. In subsequent years, the concept of 'telematic education” subsequently becomes well established in academic circles in South Africa, grew in popularity, and is adopted by many universities and colleges throughout South Africa as a medium of enhancing education and training, as a method to reaching out to far out communities, and as a means to enhance study from the home environment.\r\n\r\nProfessor Snyman in subsequent years pursued research in semiconductor physics, semiconductor devices, microelectronics, and optoelectronics.\r\n\r\nIn 2000 he joined the TUT as a full professor. Here served for a period as head of the Department of Electronic Engineering. Here he makes contributions to solar energy development, microwave and optoelectronic device development, silicon photonics, as well as contributions to new mobile telecommunication systems and network planning in SA.\r\n\r\nCurrently, he teaches electronics and telecommunications at the TUT to audiences ranging from first-year students to Ph.D. level.\r\n\r\nFor his research in the field of 'Silicon Photonics” since 1990, he has published (as author and co-author) about thirty internationally reviewed articles in scientific journals, contributed to more than forty international conferences, about 25 South African provisional patents (as inventor and co-inventor), 8 PCT international patent applications until now. Of these, two USA patents applications, two European Patents, two Korean patents, and ten SA patents have been granted. A further 4 USA patents, 5 European patents, 3 Korean patents, 3 Chinese patents, and 3 Japanese patents are currently under consideration.\r\n\r\nRecently he has also published an extensive scholarly chapter in an internet open access book on 'Integrating Microphotonic Systems and MOEMS into standard Silicon CMOS Integrated circuitry”.\r\n\r\nFurthermore, Professor Snyman recently steered a new initiative at the TUT by introducing a 'Laboratory for Innovative Electronic Systems ' at the Department of Electrical Engineering. The model of this laboratory or center is to primarily combine outputs as achieved by high-level research with lower-level system development and entrepreneurship in a technical university environment. Students are allocated to projects at different levels with PhDs and Master students allocated to the generation of new knowledge and new technologies, while students at the diploma and Baccalaureus level are allocated to electronic systems development with a direct and a near application for application in industry or the commercial and public sectors in South Africa.\r\n\r\nProfessor Snyman received the WIRSAM Award of 1983 and the WIRSAM Award in 1985 in South Africa for best research papers by a young scientist at two international conferences on electron microscopy in South Africa. He subsequently received the SA Microelectronics Award for the best dissertation emanating from studies executed at a South African university in the field of Physics and Microelectronics in South Africa in 1987. In October of 2011, Professor Snyman received the prestigious Institutional Award for 'Innovator of the Year” for 2010 at the Tshwane University of Technology, South Africa. This award was based on the number of patents recognized and granted by local and international institutions as well as for his contributions concerning innovation at the TUT.",institutionString:null,institution:{name:"University of South Africa",country:{name:"South Africa"}}},{id:"317279",title:"Mr.",name:"Ali",middleName:"Usama",surname:"Syed",slug:"ali-syed",fullName:"Ali Syed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/317279/images/16024_n.png",biography:"A creative, talented, and innovative young professional who is dedicated, well organized, and capable research fellow with two years of experience in graduate-level research, published in engineering journals and book, with related expertise in Bio-robotics, equally passionate about the aesthetics of the mechanical and electronic system, obtained expertise in the use of MS Office, MATLAB, SolidWorks, LabVIEW, Proteus, Fusion 360, having a grasp on python, C++ and assembly language, possess proven ability in acquiring research grants, previous appointments with social and educational societies with experience in administration, current affiliations with IEEE and Web of Science, a confident presenter at conferences and teacher in classrooms, able to explain complex information to audiences of all levels.",institutionString:null,institution:{name:"Air University",country:{name:"Pakistan"}}},{id:"75526",title:"Ph.D.",name:"Zihni Onur",middleName:null,surname:"Uygun",slug:"zihni-onur-uygun",fullName:"Zihni Onur Uygun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/75526/images/12_n.jpg",biography:"My undergraduate education and my Master of Science educations at Ege University and at Çanakkale Onsekiz Mart University have given me a firm foundation in Biochemistry, Analytical Chemistry, Biosensors, Bioelectronics, Physical Chemistry and Medicine. After obtaining my degree as a MSc in analytical chemistry, I started working as a research assistant in Ege University Medical Faculty in 2014. In parallel, I enrolled to the MSc program at the Department of Medical Biochemistry at Ege University to gain deeper knowledge on medical and biochemical sciences as well as clinical chemistry in 2014. In my PhD I deeply researched on biosensors and bioelectronics and finished in 2020. Now I have eleven SCI-Expanded Index published papers, 6 international book chapters, referee assignments for different SCIE journals, one international patent pending, several international awards, projects and bursaries. In parallel to my research assistant position at Ege University Medical Faculty, Department of Medical Biochemistry, in April 2016, I also founded a Start-Up Company (Denosens Biotechnology LTD) by the support of The Scientific and Technological Research Council of Turkey. Currently, I am also working as a CEO in Denosens Biotechnology. The main purposes of the company, which carries out R&D as a research center, are to develop new generation biosensors and sensors for both point-of-care diagnostics; such as glucose, lactate, cholesterol and cancer biomarker detections. My specific experimental and instrumental skills are Biochemistry, Biosensor, Analytical Chemistry, Electrochemistry, Mobile phone based point-of-care diagnostic device, POCTs and Patient interface designs, HPLC, Tandem Mass Spectrometry, Spectrophotometry, ELISA.",institutionString:null,institution:{name:"Ege University",country:{name:"Turkey"}}},{id:"267434",title:"Dr.",name:"Rohit",middleName:null,surname:"Raja",slug:"rohit-raja",fullName:"Rohit Raja",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/267434/images/system/267434.jpg",biography:"Dr. Rohit Raja received Ph.D. in Computer Science and Engineering from Dr. CVRAMAN University in 2016. His main research interest includes Face recognition and Identification, Digital Image Processing, Signal Processing, and Networking. Presently he is working as Associate Professor in IT Department, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur (CG), India. He has authored several Journal and Conference Papers. He has good Academics & Research experience in various areas of CSE and IT. He has filed and successfully published 27 Patents. He has received many time invitations to be a Guest at IEEE Conferences. He has published 100 research papers in various International/National Journals (including IEEE, Springer, etc.) and Proceedings of the reputed International/ National Conferences (including Springer and IEEE). He has been nominated to the board of editors/reviewers of many peer-reviewed and refereed Journals (including IEEE, Springer).",institutionString:"Guru Ghasidas Vishwavidyalaya",institution:{name:"Guru Ghasidas Vishwavidyalaya",country:{name:"India"}}},{id:"246502",title:"Dr.",name:"Jaya T.",middleName:"T",surname:"Varkey",slug:"jaya-t.-varkey",fullName:"Jaya T. Varkey",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246502/images/11160_n.jpg",biography:"Jaya T. Varkey, PhD, graduated with a degree in Chemistry from Cochin University of Science and Technology, Kerala, India. She obtained a PhD in Chemistry from the School of Chemical Sciences, Mahatma Gandhi University, Kerala, India, and completed a post-doctoral fellowship at the University of Minnesota, USA. She is a research guide at Mahatma Gandhi University and Associate Professor in Chemistry, St. Teresa’s College, Kochi, Kerala, India.\nDr. Varkey received a National Young Scientist award from the Indian Science Congress (1995), a UGC Research award (2016–2018), an Indian National Science Academy (INSA) Visiting Scientist award (2018–2019), and a Best Innovative Faculty award from the All India Association for Christian Higher Education (AIACHE) (2019). She Hashas received the Sr. Mary Cecil prize for best research paper three times. She was also awarded a start-up to develop a tea bag water filter. \nDr. Varkey has published two international books and twenty-seven international journal publications. She is an editorial board member for five international journals.",institutionString:"St. Teresa’s College",institution:null},{id:"250668",title:"Dr.",name:"Ali",middleName:null,surname:"Nabipour Chakoli",slug:"ali-nabipour-chakoli",fullName:"Ali Nabipour Chakoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/250668/images/system/250668.jpg",biography:"Academic Qualification:\r\n•\tPhD in Materials Physics and Chemistry, From: Sep. 2006, to: Sep. 2010, School of Materials Science and Engineering, Harbin Institute of Technology, Thesis: Structure and Shape Memory Effect of Functionalized MWCNTs/poly (L-lactide-co-ε-caprolactone) Nanocomposites. Supervisor: Prof. Wei Cai,\r\n•\tM.Sc in Applied Physics, From: 1996, to: 1998, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Determination of Boron in Micro alloy Steels with solid state nuclear track detectors by neutron induced auto radiography, Supervisors: Dr. M. Hosseini Ashrafi and Dr. A. Hosseini.\r\n•\tB.Sc. in Applied Physics, From: 1991, to: 1996, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Design of shielding for Am-Be neutron sources for In Vivo neutron activation analysis, Supervisor: Dr. M. Hosseini Ashrafi.\r\n\r\nResearch Experiences:\r\n1.\tNanomaterials, Carbon Nanotubes, Graphene: Synthesis, Functionalization and Characterization,\r\n2.\tMWCNTs/Polymer Composites: Fabrication and Characterization, \r\n3.\tShape Memory Polymers, Biodegradable Polymers, ORC, Collagen,\r\n4.\tMaterials Analysis and Characterizations: TEM, SEM, XPS, FT-IR, Raman, DSC, DMA, TGA, XRD, GPC, Fluoroscopy, \r\n5.\tInteraction of Radiation with Mater, Nuclear Safety and Security, NDT(RT),\r\n6.\tRadiation Detectors, Calibration (SSDL),\r\n7.\tCompleted IAEA e-learning Courses:\r\nNuclear Security (15 Modules),\r\nNuclear Safety:\r\nTSA 2: Regulatory Protection in Occupational Exposure,\r\nTips & Tricks: Radiation Protection in Radiography,\r\nSafety and Quality in Radiotherapy,\r\nCourse on Sealed Radioactive Sources,\r\nCourse on Fundamentals of Environmental Remediation,\r\nCourse on Planning for Environmental Remediation,\r\nKnowledge Management Orientation Course,\r\nFood Irradiation - Technology, Applications and Good Practices,\r\nEmployment:\r\nFrom 2010 to now: Academic staff, Nuclear Science and Technology Research Institute, Kargar Shomali, Tehran, Iran, P.O. Box: 14395-836.\r\nFrom 1997 to 2006: Expert of Materials Analysis and Characterization. Research Center of Agriculture and Medicine. Rajaeeshahr, Karaj, Iran, P. O. Box: 31585-498.",institutionString:"Atomic Energy Organization of Iran",institution:{name:"Atomic Energy Organization of Iran",country:{name:"Iran"}}},{id:"248279",title:"Dr.",name:"Monika",middleName:"Elzbieta",surname:"Machoy",slug:"monika-machoy",fullName:"Monika Machoy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248279/images/system/248279.jpeg",biography:"Monika Elżbieta Machoy, MD, graduated with distinction from the Faculty of Medicine and Dentistry at the Pomeranian Medical University in 2009, defended her PhD thesis with summa cum laude in 2016 and is currently employed as a researcher at the Department of Orthodontics of the Pomeranian Medical University. She expanded her professional knowledge during a one-year scholarship program at the Ernst Moritz Arndt University in Greifswald, Germany and during a three-year internship at the Technical University in Dresden, Germany. She has been a speaker at numerous orthodontic conferences, among others, American Association of Orthodontics, European Orthodontic Symposium and numerous conferences of the Polish Orthodontic Society. She conducts research focusing on the effect of orthodontic treatment on dental and periodontal tissues and the causes of pain in orthodontic patients.",institutionString:"Pomeranian Medical University",institution:{name:"Pomeranian Medical University",country:{name:"Poland"}}},{id:"252743",title:"Prof.",name:"Aswini",middleName:"Kumar",surname:"Kar",slug:"aswini-kar",fullName:"Aswini Kar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252743/images/10381_n.jpg",biography:"uploaded in cv",institutionString:null,institution:{name:"KIIT University",country:{name:"India"}}},{id:"204256",title:"Dr.",name:"Anil",middleName:"Kumar",surname:"Kumar Sahu",slug:"anil-kumar-sahu",fullName:"Anil Kumar Sahu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204256/images/14201_n.jpg",biography:"I have nearly 11 years of research and teaching experience. I have done my master degree from University Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur, Chhattisgarh India. I have published 16 review and research articles in international and national journals and published 4 chapters in IntechOpen, the world’s leading publisher of Open access books. I have presented many papers at national and international conferences. I have received research award from Indian Drug Manufacturers Association in year 2015. My research interest extends from novel lymphatic drug delivery systems, oral delivery system for herbal bioactive to formulation optimization.",institutionString:null,institution:{name:"Chhattisgarh Swami Vivekanand Technical University",country:{name:"India"}}},{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",biography:"An assistant professor at Department of Biomedical Computer Systems, at Institute of Computer Science, Silesian University in Katowice. Scientific interests: computer analysis and processing of images, biomedical images, databases and programming languages. He is an author and co-author of scientific publications covering analysis and processing of biomedical images and development of database systems.",institutionString:"University of Silesia",institution:null},{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",biography:"Dr. Hadi Mohammadi is a biomedical engineer with hands-on experience in the design and development of many engineering structures and medical devices through various projects that he has been involved in over the past twenty years. Dr. Mohammadi received his BSc. and MSc. degrees in Mechanical Engineering from Sharif University of Technology, Tehran, Iran, and his PhD. degree in Biomedical Engineering (biomaterials) from the University of Western Ontario. He was a postdoctoral trainee for almost four years at University of Calgary and Harvard Medical School. He is an industry innovator having created the technology to produce lifelike synthetic platforms that can be used for the simulation of almost all cardiovascular reconstructive surgeries. He’s been heavily involved in the design and development of cardiovascular devices and technology for the past 10 years. He is currently an Assistant Professor with the University of British Colombia, Canada.",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",country:{name:"Canada"}}},{id:"254463",title:"Prof.",name:"Haisheng",middleName:null,surname:"Yang",slug:"haisheng-yang",fullName:"Haisheng Yang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/254463/images/system/254463.jpeg",biography:"Haisheng Yang, Ph.D., Professor and Director of the Department of Biomedical Engineering, College of Life Science and Bioengineering, Beijing University of Technology. He received his Ph.D. degree in Mechanics/Biomechanics from Harbin Institute of Technology (jointly with University of California, Berkeley). Afterwards, he worked as a Postdoctoral Research Associate in the Purdue Musculoskeletal Biology and Mechanics Lab at the Department of Basic Medical Sciences, Purdue University, USA. He also conducted research in the Research Centre of Shriners Hospitals for Children-Canada at McGill University, Canada. Dr. Yang has over 10 years research experience in orthopaedic biomechanics and mechanobiology of bone adaptation and regeneration. He earned an award from Beijing Overseas Talents Aggregation program in 2017 and serves as Beijing Distinguished Professor.",institutionString:null,institution:{name:"Beijing University of Technology",country:{name:"China"}}},{id:"89721",title:"Dr.",name:"Mehmet",middleName:"Cuneyt",surname:"Ozmen",slug:"mehmet-ozmen",fullName:"Mehmet Ozmen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/89721/images/7289_n.jpg",biography:null,institutionString:null,institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"242893",title:"Ph.D. Student",name:"Joaquim",middleName:null,surname:"De Moura",slug:"joaquim-de-moura",fullName:"Joaquim De Moura",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/242893/images/7133_n.jpg",biography:"Joaquim de Moura received his degree in Computer Engineering in 2014 from the University of A Coruña (Spain). In 2016, he received his M.Sc degree in Computer Engineering from the same university. He is currently pursuing his Ph.D degree in Computer Science in a collaborative project between ophthalmology centers in Galicia and the University of A Coruña. His research interests include computer vision, machine learning algorithms and analysis and medical imaging processing of various kinds.",institutionString:null,institution:{name:"University of A Coruña",country:{name:"Spain"}}},{id:"294334",title:"B.Sc.",name:"Marc",middleName:null,surname:"Bruggeman",slug:"marc-bruggeman",fullName:"Marc Bruggeman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/294334/images/8242_n.jpg",biography:"Chemical engineer graduate, with a passion for material science and specific interest in polymers - their near infinite applications intrigue me. \n\nI plan to continue my scientific career in the field of polymeric biomaterials as I am fascinated by intelligent, bioactive and biomimetic materials for use in both consumer and medical applications.",institutionString:null,institution:null},{id:"255757",title:"Dr.",name:"Igor",middleName:"Victorovich",surname:"Lakhno",slug:"igor-lakhno",fullName:"Igor Lakhno",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255757/images/system/255757.jpg",biography:"Igor Victorovich Lakhno was born in 1971 in Kharkiv (Ukraine). \nMD – 1994, Kharkiv National Medical Univesity.\nOb&Gyn; – 1997, master courses in Kharkiv Medical Academy of Postgraduate Education.\nPh.D. – 1999, Kharkiv National Medical Univesity.\nDSC – 2019, PL Shupik National Academy of Postgraduate Education \nProfessor – 2021, Department of Obstetrics and Gynecology of VN Karazin Kharkiv National University\nHead of Department – 2021, Department of Perinatology, Obstetrics and gynecology of Kharkiv Medical Academy of Postgraduate Education\nIgor Lakhno has been graduated from international training courses on reproductive medicine and family planning held at Debrecen University (Hungary) in 1997. Since 1998 Lakhno Igor has worked as an associate professor in the department of obstetrics and gynecology of VN Karazin National University and an associate professor of the perinatology, obstetrics, and gynecology department of Kharkiv Medical Academy of Postgraduate Education. Since June 2019 he’s been a professor in the department of obstetrics and gynecology of VN Karazin National University and a professor of the perinatology, obstetrics, and gynecology department. He’s affiliated with Kharkiv Medical Academy of Postgraduate Education as a Head of Department from November 2021. Igor Lakhno has participated in several international projects on fetal non-invasive electrocardiography (with Dr. J. A. Behar (Technion), Prof. D. Hoyer (Jena University), and José Alejandro Díaz Méndez (National Institute of Astrophysics, Optics, and Electronics, Mexico). He’s an author of about 200 printed works and there are 31 of them in Scopus or Web of Science databases. Igor Lakhno is a member of the Editorial Board of Reproductive Health of Woman, Emergency Medicine, and Technology Transfer Innovative Solutions in Medicine (Estonia). He is a medical Editor of “Z turbotoyu pro zhinku”. Igor Lakhno is a reviewer of the Journal of Obstetrics and Gynaecology (Taylor and Francis), British Journal of Obstetrics and Gynecology (Wiley), Informatics in Medicine Unlocked (Elsevier), The Journal of Obstetrics and Gynecology Research (Wiley), Endocrine, Metabolic & Immune Disorders-Drug Targets (Bentham Open), The Open Biomedical Engineering Journal (Bentham Open), etc. He’s defended a dissertation for a DSc degree “Pre-eclampsia: prediction, prevention, and treatment”. Three years ago Igor Lakhno has participated in a training course on innovative technologies in medical education at Lublin Medical University (Poland). Lakhno Igor has participated as a speaker in several international conferences and congresses (International Conference on Biological Oscillations April 10th-14th 2016, Lancaster, UK, The 9th conference of the European Study Group on Cardiovascular Oscillations). His main scientific interests: are obstetrics, women’s health, fetal medicine, and cardiovascular medicine. \nIgor Lakhno is a consultant at Kharkiv municipal perinatal center. He’s graduated from training courses on endoscopy in gynecology. He has 28 years of practical experience in the field.",institutionString:null,institution:null},{id:"244950",title:"Dr.",name:"Salvatore",middleName:null,surname:"Di Lauro",slug:"salvatore-di-lauro",fullName:"Salvatore Di Lauro",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0030O00002bSF1HQAW/ProfilePicture%202021-12-20%2014%3A54%3A14.482",biography:"Name:\n\tSALVATORE DI LAURO\nAddress:\n\tHospital Clínico Universitario Valladolid\nAvda Ramón y Cajal 3\n47005, Valladolid\nSpain\nPhone number: \nFax\nE-mail:\n\t+34 983420000 ext 292\n+34 983420084\nsadilauro@live.it\nDate and place of Birth:\nID Number\nMedical Licence \nLanguages\t09-05-1985. Villaricca (Italy)\n\nY1281863H\n474707061\nItalian (native language)\nSpanish (read, written, spoken)\nEnglish (read, written, spoken)\nPortuguese (read, spoken)\nFrench (read)\n\t\t\nCurrent position (title and company)\tDate (Year)\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. Private practise.\t2017-today\n\n2019-today\n\t\n\t\nEducation (High school, university and postgraduate training > 3 months)\tDate (Year)\nDegree in Medicine and Surgery. University of Neaples 'Federico II”\nResident in Opthalmology. Hospital Clinico Universitario Valladolid\nMaster in Vitreo-Retina. IOBA. University of Valladolid\nFellow of the European Board of Ophthalmology. Paris\nMaster in Research in Ophthalmology. University of Valladolid\t2003-2009\n2012-2016\n2016-2017\n2016\n2012-2013\n\t\nEmployments (company and positions)\tDate (Year)\nResident in Ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl.\nFellow in Vitreo-Retina. IOBA. University of Valladolid\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. \n\t2012-2016\n2016-2017\n2017-today\n\n2019-Today\n\n\n\t\nClinical Research Experience (tasks and role)\tDate (Year)\nAssociated investigator\n\n' FIS PI20/00740: DESARROLLO DE UNA CALCULADORA DE RIESGO DE\nAPARICION DE RETINOPATIA DIABETICA BASADA EN TECNICAS DE IMAGEN MULTIMODAL EN PACIENTES DIABETICOS TIPO 1. Grant by: Ministerio de Ciencia e Innovacion \n\n' (BIO/VA23/14) Estudio clínico multicéntrico y prospectivo para validar dos\nbiomarcadores ubicados en los genes p53 y MDM2 en la predicción de los resultados funcionales de la cirugía del desprendimiento de retina regmatógeno. Grant by: Gerencia Regional de Salud de la Junta de Castilla y León.\n' Estudio multicéntrico, aleatorizado, con enmascaramiento doble, en 2 grupos\nparalelos y de 52 semanas de duración para comparar la eficacia, seguridad e inmunogenicidad de SOK583A1 respecto a Eylea® en pacientes con degeneración macular neovascular asociada a la edad' (CSOK583A12301; N.EUDRA: 2019-004838-41; FASE III). Grant by Hexal AG\n\n' Estudio de fase III, aleatorizado, doble ciego, con grupos paralelos, multicéntrico para comparar la eficacia y la seguridad de QL1205 frente a Lucentis® en pacientes con degeneración macular neovascular asociada a la edad. (EUDRACT: 2018-004486-13). Grant by Qilu Pharmaceutical Co\n\n' Estudio NEUTON: Ensayo clinico en fase IV para evaluar la eficacia de aflibercept en pacientes Naive con Edema MacUlar secundario a Oclusion de Vena CenTral de la Retina (OVCR) en regimen de tratamientO iNdividualizado Treat and Extend (TAE)”, (2014-000975-21). Grant by Fundacion Retinaplus\n\n' Evaluación de la seguridad y bioactividad de anillos de tensión capsular en conejo. Proyecto Procusens. Grant by AJL, S.A.\n\n'Estudio epidemiológico, prospectivo, multicéntrico y abierto\\npara valorar la frecuencia de la conjuntivitis adenovírica diagnosticada mediante el test AdenoPlus®\\nTest en pacientes enfermos de conjuntivitis aguda”\\n. National, multicenter study. Grant by: NICOX.\n\nEuropean multicentric trial: 'Evaluation of clinical outcomes following the use of Systane Hydration in patients with dry eye”. Study Phase 4. Grant by: Alcon Labs'\n\nVLPs Injection and Activation in a Rabbit Model of Uveal Melanoma. Grant by Aura Bioscience\n\nUpdating and characterization of a rabbit model of uveal melanoma. Grant by Aura Bioscience\n\nEnsayo clínico en fase IV para evaluar las variantes genéticas de la vía del VEGF como biomarcadores de eficacia del tratamiento con aflibercept en pacientes con degeneración macular asociada a la edad (DMAE) neovascular. Estudio BIOIMAGE. IMO-AFLI-2013-01\n\nEstudio In-Eye:Ensayo clínico en fase IV, abierto, aleatorizado, de 2 brazos,\nmulticçentrico y de 12 meses de duración, para evaluar la eficacia y seguridad de un régimen de PRN flexible individualizado de 'esperar y extender' versus un régimen PRN según criterios de estabilización mediante evaluaciones mensuales de inyecciones intravítreas de ranibizumab 0,5 mg en pacientes naive con neovascularización coriodea secunaria a la degeneración macular relacionada con la edad. CP: CRFB002AES03T\n\nTREND: Estudio Fase IIIb multicéntrico, randomizado, de 12 meses de\nseguimiento con evaluador de la agudeza visual enmascarado, para evaluar la eficacia y la seguridad de ranibizumab 0.5mg en un régimen de tratar y extender comparado con un régimen mensual, en pacientes con degeneración macular neovascular asociada a la edad. CP: CRFB002A2411 Código Eudra CT:\n2013-002626-23\n\n\n\nPublications\t\n\n2021\n\n\n\n\n2015\n\n\n\n\n2021\n\n\n\n\n\n2021\n\n\n\n\n2015\n\n\n\n\n2015\n\n\n2014\n\n\n\n\n2015-16\n\n\n\n2015\n\n\n2014\n\n\n2014\n\n\n\n\n2014\n\n\n\n\n\n\n\n2014\n\nJose Carlos Pastor; Jimena Rojas; Salvador Pastor-Idoate; Salvatore Di Lauro; Lucia Gonzalez-Buendia; Santiago Delgado-Tirado. Proliferative vitreoretinopathy: A new concept of disease pathogenesis and practical\nconsequences. Progress in Retinal and Eye Research. 51, pp. 125 - 155. 03/2016. DOI: 10.1016/j.preteyeres.2015.07.005\n\n\nLabrador-Velandia S; Alonso-Alonso ML; Di Lauro S; García-Gutierrez MT; Srivastava GK; Pastor JC; Fernandez-Bueno I. Mesenchymal stem cells provide paracrine neuroprotective resources that delay degeneration of co-cultured organotypic neuroretinal cultures.Experimental Eye Research. 185, 17/05/2019. DOI: 10.1016/j.exer.2019.05.011\n\nSalvatore Di Lauro; Maria Teresa Garcia Gutierrez; Ivan Fernandez Bueno. Quantification of pigment epithelium-derived factor (PEDF) in an ex vivo coculture of retinal pigment epithelium cells and neuroretina.\nJournal of Allbiosolution. 2019. ISSN 2605-3535\n\nSonia Labrador Velandia; Salvatore Di Lauro; Alonso-Alonso ML; Tabera Bartolomé S; Srivastava GK; Pastor JC; Fernandez-Bueno I. Biocompatibility of intravitreal injection of human mesenchymal stem cells in immunocompetent rabbits. Graefe's archive for clinical and experimental ophthalmology. 256 - 1, pp. 125 - 134. 01/2018. DOI: 10.1007/s00417-017-3842-3\n\n\nSalvatore Di Lauro, David Rodriguez-Crespo, Manuel J Gayoso, Maria T Garcia-Gutierrez, J Carlos Pastor, Girish K Srivastava, Ivan Fernandez-Bueno. A novel coculture model of porcine central neuroretina explants and retinal pigment epithelium cells. Molecular Vision. 2016 - 22, pp. 243 - 253. 01/2016.\n\nSalvatore Di Lauro. Classifications for Proliferative Vitreoretinopathy ({PVR}): An Analysis of Their Use in Publications over the Last 15 Years. Journal of Ophthalmology. 2016, pp. 1 - 6. 01/2016. DOI: 10.1155/2016/7807596\n\nSalvatore Di Lauro; Rosa Maria Coco; Rosa Maria Sanabria; Enrique Rodriguez de la Rua; Jose Carlos Pastor. Loss of Visual Acuity after Successful Surgery for Macula-On Rhegmatogenous Retinal Detachment in a Prospective Multicentre Study. Journal of Ophthalmology. 2015:821864, 2015. DOI: 10.1155/2015/821864\n\nIvan Fernandez-Bueno; Salvatore Di Lauro; Ivan Alvarez; Jose Carlos Lopez; Maria Teresa Garcia-Gutierrez; Itziar Fernandez; Eva Larra; Jose Carlos Pastor. Safety and Biocompatibility of a New High-Density Polyethylene-Based\nSpherical Integrated Porous Orbital Implant: An Experimental Study in Rabbits. Journal of Ophthalmology. 2015:904096, 2015. DOI: 10.1155/2015/904096\n\nPastor JC; Pastor-Idoate S; Rodríguez-Hernandez I; Rojas J; Fernandez I; Gonzalez-Buendia L; Di Lauro S; Gonzalez-Sarmiento R. Genetics of PVR and RD. Ophthalmologica. 232 - Suppl 1, pp. 28 - 29. 2014\n\nRodriguez-Crespo D; Di Lauro S; Singh AK; Garcia-Gutierrez MT; Garrosa M; Pastor JC; Fernandez-Bueno I; Srivastava GK. Triple-layered mixed co-culture model of RPE cells with neuroretina for evaluating the neuroprotective effects of adipose-MSCs. Cell Tissue Res. 358 - 3, pp. 705 - 716. 2014.\nDOI: 10.1007/s00441-014-1987-5\n\nCarlo De Werra; Salvatore Condurro; Salvatore Tramontano; Mario Perone; Ivana Donzelli; Salvatore Di Lauro; Massimo Di Giuseppe; Rosa Di Micco; Annalisa Pascariello; Antonio Pastore; Giorgio Diamantis; Giuseppe Galloro. Hydatid disease of the liver: thirty years of surgical experience.Chirurgia italiana. 59 - 5, pp. 611 - 636.\n(Italia): 2007. ISSN 0009-4773\n\nChapters in books\n\t\n' Salvador Pastor Idoate; Salvatore Di Lauro; Jose Carlos Pastor Jimeno. PVR: Pathogenesis, Histopathology and Classification. Proliferative Vitreoretinopathy with Small Gauge Vitrectomy. Springer, 2018. ISBN 978-3-319-78445-8\nDOI: 10.1007/978-3-319-78446-5_2. \n\n' Salvatore Di Lauro; Maria Isabel Lopez Galvez. Quistes vítreos en una mujer joven. Problemas diagnósticos en patología retinocoroidea. Sociedad Española de Retina-Vitreo. 2018.\n\n' Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor Jimeno. iOCT in PVR management. OCT Applications in Opthalmology. pp. 1 - 8. INTECH, 2018. DOI: 10.5772/intechopen.78774.\n\n' Rosa Coco Martin; Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor. amponadores, manipuladores y tinciones en la cirugía del traumatismo ocular.Trauma Ocular. Ponencia de la SEO 2018..\n\n' LOPEZ GALVEZ; DI LAURO; CRESPO. OCT angiografia y complicaciones retinianas de la diabetes. PONENCIA SEO 2021, CAPITULO 20. (España): 2021.\n\n' Múltiples desprendimientos neurosensoriales bilaterales en paciente joven. Enfermedades Degenerativas De Retina Y Coroides. SERV 04/2016. \n' González-Buendía L; Di Lauro S; Pastor-Idoate S; Pastor Jimeno JC. Vitreorretinopatía proliferante (VRP) e inflamación: LA INFLAMACIÓN in «INMUNOMODULADORES Y ANTIINFLAMATORIOS: MÁS ALLÁ DE LOS CORTICOIDES. RELACION DE PONENCIAS DE LA SOCIEDAD ESPAÑOLA DE OFTALMOLOGIA. 10/2014.",institutionString:null,institution:null},{id:"265335",title:"Mr.",name:"Stefan",middleName:"Radnev",surname:"Stefanov",slug:"stefan-stefanov",fullName:"Stefan Stefanov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/265335/images/7562_n.jpg",biography:null,institutionString:null,institution:null},{id:"243698",title:"Dr.",name:"Xiaogang",middleName:null,surname:"Wang",slug:"xiaogang-wang",fullName:"Xiaogang Wang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243698/images/system/243698.png",biography:"Dr. Xiaogang Wang, a faculty member of Shanxi Eye Hospital specializing in the treatment of cataract and retinal disease and a tutor for postgraduate students of Shanxi Medical University, worked in the COOL Lab as an international visiting scholar under the supervision of Dr. David Huang and Yali Jia from October 2012 through November 2013. Dr. Wang earned an MD from Shanxi Medical University and a Ph.D. from Shanghai Jiao Tong University. Dr. Wang was awarded two research project grants focused on multimodal optical coherence tomography imaging and deep learning in cataract and retinal disease, from the National Natural Science Foundation of China. He has published around 30 peer-reviewed journal papers and four book chapters and co-edited one book.",institutionString:null,institution:null},{id:"7227",title:"Dr.",name:"Hiroaki",middleName:null,surname:"Matsui",slug:"hiroaki-matsui",fullName:"Hiroaki Matsui",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Tokyo",country:{name:"Japan"}}},{id:"318905",title:"Prof.",name:"Elvis",middleName:"Kwason",surname:"Tiburu",slug:"elvis-tiburu",fullName:"Elvis Tiburu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Ghana",country:{name:"Ghana"}}},{id:"336193",title:"Dr.",name:"Abdullah",middleName:null,surname:"Alamoudi",slug:"abdullah-alamoudi",fullName:"Abdullah Alamoudi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"318657",title:"MSc.",name:"Isabell",middleName:null,surname:"Steuding",slug:"isabell-steuding",fullName:"Isabell Steuding",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Harz University of Applied Sciences",country:{name:"Germany"}}},{id:"318656",title:"BSc.",name:"Peter",middleName:null,surname:"Kußmann",slug:"peter-kussmann",fullName:"Peter Kußmann",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Harz University of Applied Sciences",country:{name:"Germany"}}},{id:"338222",title:"Mrs.",name:"María José",middleName:null,surname:"Lucía Mudas",slug:"maria-jose-lucia-mudas",fullName:"María José Lucía Mudas",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Carlos III University of Madrid",country:{name:"Spain"}}}]}},subseries:{item:{id:"90",type:"subseries",title:"Human Development",keywords:"Neuroscientific research, Brain functions, Human development, UN’s human development index, Self-awareness, Self-development",scope:"