Relationship between Zernike order and azimuthal and radial orders
\r\n\tThe present book intends to provide to the reader a comprehensive overview of the state of art in empathy studies, embracing the different theoretical points of view and illustrating the advanced research such as the application of new technologies to promote perspective-taking. The critical aspects and the future directions of the study on empathy will also be presented.
",isbn:"978-1-80356-612-2",printIsbn:"978-1-80356-611-5",pdfIsbn:"978-1-80356-613-9",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!1,isSalesforceBook:!1,isNomenclature:!1,hash:"4c1042dfe15aa9cea6019524c4cbff38",bookSignature:"Ph.D. Sara Ventura",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11443.jpg",keywords:"Theoretical Model, Skill, Perspective Taking, Training Programs, Practical Implications, Advanced Research, Future Directions, Virtual Reality, Augmented Reality, New Trends, Assistive Technology",numberOfDownloads:20,numberOfWosCitations:0,numberOfCrossrefCitations:0,numberOfDimensionsCitations:0,numberOfTotalCitations:0,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"April 1st 2022",dateEndSecondStepPublish:"June 8th 2022",dateEndThirdStepPublish:"August 7th 2022",dateEndFourthStepPublish:"October 26th 2022",dateEndFifthStepPublish:"December 25th 2022",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"2 months",secondStepPassed:!0,areRegistrationsClosed:!0,currentStepOfPublishingProcess:4,editedByType:null,kuFlag:!1,biosketch:"Passionate researcher in the application of new technologies to psychological treatments, neuro-rehabilitation, human behavior, and the evolution of the human-computer interaction. In 2017 Dr. Ventura won a competitive grant (Santiago Grisolia) at the University of Valencia at LABPSITEC group, where she was awarded her Ph.D. degree, supervised by Prof. Rosa Baños at the University of Valencia, and co-directed by Prof. Giuseppe Riva of the Catholic University of Milan.",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"227763",title:"Ph.D.",name:"Sara",middleName:null,surname:"Ventura",slug:"sara-ventura",fullName:"Sara Ventura",profilePictureURL:"https://mts.intechopen.com/storage/users/227763/images/system/227763.jpg",biography:"Sara Ventura gained a B.Sc in Psychology at the University of Padua (Italy) in 2013 and an M.Sc. in Ergonomic Psychology at the Catholic University of Milan (Italy) in 2015. In 2016, she carried out a postgraduate training at Universidad Nacional Autónoma de Mexico (Mexico) at the Ciberpsychology lab, working on a rehabilitation protocol for people with acquired brain injury through Virtual Reality. In 2020, Sara gained the Ph.D. in Clinical Psychology at University of Valencia (Spain) working with the LabPsitec group and focusing her research on the study of embodiment and empathy with the support of Virtual Reality. Actually, she is working both with Alma Mater Studiorum – University of Bologna (Italy), and the University of Valencia (Spain) on the fields of embodiment, stroke rehabilitation, empathy and patient care. Her research interests mainly focus on the adoption of new technologies, particularly Virtual/Augmented Reality and Artificial Intelligence for the psycho-social wellbeing with clinical and non-clinical populations, the study of human-computer interaction, and the user experience. She is the author of several scientific papers and various presentations at national and international conferences.",institutionString:"University of Valencia",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"University of Valencia",institutionURL:null,country:{name:"Spain"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"21",title:"Psychology",slug:"psychology"}],chapters:[{id:"82719",title:"Empathy as a High-Performance Competency",slug:"empathy-as-a-high-performance-competency",totalDownloads:14,totalCrossrefCites:0,authors:[null]},{id:"82888",title:"From Empathy to the Aggression–Compassion Continuum",slug:"from-empathy-to-the-aggression-compassion-continuum",totalDownloads:6,totalCrossrefCites:0,authors:[{id:"191531",title:"Dr.",name:"Neil E.",surname:"Grunberg",slug:"neil-e.-grunberg",fullName:"Neil E. 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After a long distance, the wavefront, or surface of equal phase, will be flat; as is illustrated in Fig. 1.
\n\t\t\tFlat wavefront after a long propagation distance from a point source
When the light begins to propagate through Earth’s atmosphere, the varying index of refraction will alter the optical path, as shown in Fig. 2. The Earth’s atmosphere can be described as a locally homogeneous medium in which its properties vary with respect to temperature, pressure, wind velocities, humidity and many other factors. Also, the Earth’s atmosphere temporally changes in a quasi-random fashion. All of these processes are usually simply refered to as ``atmospheric turbulence’’. The Kolmogorov model of energy distribution in a turbulent medium is a useful statistical model to describe the fluctuation in refractive index due to mostly the humidity and pressure changes. This model was first proposed by a Russian mathematician named Andreï Kolmogorov in 1941 and describes how in a fully turbulent media the kinetic energy of large scale motions is transfered to smaller and smaller scale motions (Kolmogorov, 1941). It is supported by a variety of experimental measurements and is quite widely used in simulations for the propagation of electromagnetic waves through a random medium. The first author to fully describe such phenomena was Tatarski in his textbook ``Wave propagation in a turbulent medium’’ (Tatarski, 1961). The complex and random nature of the Earth’s atmospheric turbulence effect on wave propagation is currently a subject of active research and experimental measurements. Many of the parameters of Earth’s atmospheric turbulence can be, at best, described statistically.
\n\t\t\tPropagation of light from a distant source that then passes through the atmosphere
These statistical parameters represent the strength and changeability of the atmospheric turbulence, these conditions are customarily refered to as the ``astronomical seeing’’, as they are widely used for astronomical applications. It is with this statistical information about a certain astronomical site and the specifications of the telescope that an Adaptive Optics (AO) system can be designed to correct the wavefront distortions caused by the atmosphere at that site. As telescopes continue to be manufactured larger and larger, the need for AO is increasing because of the limiting factors caused by atmospheric turbulence. In order to adequately characterize the performance of a particular AO system, an accurate spatial and temporal model of the Earth’s atmosphere is required.
\n\t\t\tAO is the term used for a class of techniques dealing with the correction of wavefront distortions in an optical system in real time. Some wavefront distortions may include those caused by the atmosphere. Astronomical applications of AO particularly include the correction of atmospheric turbulence for a telescope system. Other possible applications include Free Space Laser Communications, High Energy Laser Applications, and Phase-Correction for Deployable Space-Based Telescopes and Imaging systems. However, prior to deployment, an AO system requires calibration and full characterization in a laboratory environment.
\n\t\t\tMany techniques are currently being used with AO systems for simulating atmospheric turbulence. Some static components use glass phase screens with holograms etched into them. In addition, it is also important to simulate the temporal transitions of atmospheric turbulence. Some of these methods include the use of a static aberrator, such as a clear piece of plastic or glass etched phase screen, and rotating it. Rotating filter wheels with etched holographic phase screens can simulate temporal transitions, as well. Also, simply using a hot-plate directly under the beam path in an optical system can simulate temporally the atmospheric turbulence.
\n\t\t\tHowever, etching holographic phase screens into glass can be quite costly and not very flexible to simulate different atmospheric characteristics. Thus, one would need more than one phase screen. A testbed that simulates atmospheric aberrations far more inexpensively and with greater fidelity and flexibility can be achieved using a Liquid Crystal (LC) Spatial Light Modulator (SLM). This system allows the simulation of atmospheric seeing conditions ranging from very poor to very good and different algorithms may be easily employed on the device for comparison. These simulations can be dynamically generated and modified very quickly and easily.
\n\t\tEver since Galileo took a first look at the moons of Jupiter through one of the first telescopes, astronomers have strived to understand our universe. Within the last century, telescopes have enabled us to learn about the far reaches of our universe, even the acceleration of the expansion of the universe, itself. The field of building telescopes has been advancing much in recent years. The twin Keck Telescopes on the summit of Hawaii’s dormant Mauna Kea volcano measure 10 meters and are currently the largest optical telescopes in the world. Plans and designs for building 30 and 100 meter optical telescopes are underway. As these telescope apertures continue to grow in diameter, the Earth’s atmosphere degrades the images we try to capture more and more. As Issac Newton said is his book,
In 1941, Kolmogorov published his treatise on the statistics of the energy transfer in a turbulent flow of a fluid medium. Tatarskii used this model to develop the theory of electro-magnetic wave propagation through such a turbulent medium. Then, Fried used Tatarskii’s model to introduce measurable parameters that can be used to characterize the strength of the atmospheric turbulence.
\n\t\t\t\tThe theory of linear systems allows us to understand how a system transforms an input just by defining the characteristic functions of the system itself. Such a characteristic function is represented by a linear operator operating on an impulse function. The characteristic system function is generally called the ``impulse response function’’. Very often, such an operator is the so-called Fourier transform. An imaging system can be approximated by a linear, shift-invariant system over a wide range of applications. The next few sections will explain the use of a Fourier transform in such an optical imaging system and its applications with optical aberrations.
\n\t\t\tA fantastic tool for the mathematical analysis of many types of phenomena is the Fourier transform. The 2-dimensional Fourier transform of the function
where, for an imaging system, the
There exist various properties of the Fourier transform. The linearity property states that the Fourier transform of the sum of two or more functions is the sum of their individual Fourier transforms and is shown by,
\n\t\t\t\twhere
where
where
The convolution property states that the convolution of two functions in the space domain is exactly equivalent to the multiplication of the two functions’ Fourier transforms, which is usually a much simpler operation. The convolution of two functions is defined as,
\n\t\t\t\tThe convolution property is shown as,
\n\t\t\t\tA special case of the convolution property is known as the autocorrelation property and is shown as,
\n\t\t\t\twhere the superscript * denotes the complex conjugate of the function
The spatial variation as a function of spatial frequency is described by the Optical Transfer Function (OTF). The OTF is defined as the Fourier transform of the PSF written as,
\n\t\t\t\tThe Modulation Transfer Function (MTF) is the magnitude of the OTF and is written as,
\n\t\t\t\tTwo common aperture geometries, or pupil functions, that will be discussed are the rectangular and circular apertures. The rectangular aperture is defined as,
\n\t\t\t\twhere
where
In order to include the effects of aberrations, it is useful to introduce the concept of a “generalized pupil function”. Such a function is complex in nature and the argument of the imaginary exponential is a function that represents the optical phase aberrations by,
\n\t\t\t\twhere
The primary goal of AO is to correct an aberrated, or distorted, wavefront. A wavefront with aberrations can be described by the sum of an orthonormal set of polynomials, of which there are many. One specific set is the so called Zernike polynomials,
where
\n\t\t\t\tThe azimuthal and radial orders of the Zernike polynimials,
i | \n\t\t\t\t\t\t\tn | \n\t\t\t\t\t\t\tm | \n\t\t\t\t\t\t\ti | \n\t\t\t\t\t\t\tn | \n\t\t\t\t\t\t\tm | \n\t\t\t\t\t\t\ti | \n\t\t\t\t\t\t\tn | \n\t\t\t\t\t\t\tm | \n\t\t\t\t\t\t\ti | \n\t\t\t\t\t\t\tn | \n\t\t\t\t\t\t\tm | \n\t\t\t\t\t\t
1 | \n\t\t\t\t\t\t\t0 | \n\t\t\t\t\t\t\t0 | \n\t\t\t\t\t\t\t8 | \n\t\t\t\t\t\t\t3 | \n\t\t\t\t\t\t\t-1 | \n\t\t\t\t\t\t\t15 | \n\t\t\t\t\t\t\t4 | \n\t\t\t\t\t\t\t-4 | \n\t\t\t\t\t\t\t22 | \n\t\t\t\t\t\t\t6 | \n\t\t\t\t\t\t\t0 | \n\t\t\t\t\t\t
2 | \n\t\t\t\t\t\t\t1 | \n\t\t\t\t\t\t\t1 | \n\t\t\t\t\t\t\t9 | \n\t\t\t\t\t\t\t3 | \n\t\t\t\t\t\t\t3 | \n\t\t\t\t\t\t\t16 | \n\t\t\t\t\t\t\t5 | \n\t\t\t\t\t\t\t1 | \n\t\t\t\t\t\t\t23 | \n\t\t\t\t\t\t\t6 | \n\t\t\t\t\t\t\t2 | \n\t\t\t\t\t\t
3 | \n\t\t\t\t\t\t\t1 | \n\t\t\t\t\t\t\t-1 | \n\t\t\t\t\t\t\t10 | \n\t\t\t\t\t\t\t3 | \n\t\t\t\t\t\t\t-3 | \n\t\t\t\t\t\t\t17 | \n\t\t\t\t\t\t\t5 | \n\t\t\t\t\t\t\t-1 | \n\t\t\t\t\t\t\t24 | \n\t\t\t\t\t\t\t6 | \n\t\t\t\t\t\t\t-2 | \n\t\t\t\t\t\t
4 | \n\t\t\t\t\t\t\t2 | \n\t\t\t\t\t\t\t0 | \n\t\t\t\t\t\t\t11 | \n\t\t\t\t\t\t\t4 | \n\t\t\t\t\t\t\t0 | \n\t\t\t\t\t\t\t18 | \n\t\t\t\t\t\t\t5 | \n\t\t\t\t\t\t\t3 | \n\t\t\t\t\t\t\t25 | \n\t\t\t\t\t\t\t6 | \n\t\t\t\t\t\t\t4 | \n\t\t\t\t\t\t
5 | \n\t\t\t\t\t\t\t2 | \n\t\t\t\t\t\t\t2 | \n\t\t\t\t\t\t\t12 | \n\t\t\t\t\t\t\t4 | \n\t\t\t\t\t\t\t2 | \n\t\t\t\t\t\t\t19 | \n\t\t\t\t\t\t\t5 | \n\t\t\t\t\t\t\t-3 | \n\t\t\t\t\t\t\t26 | \n\t\t\t\t\t\t\t6 | \n\t\t\t\t\t\t\t-4 | \n\t\t\t\t\t\t
6 | \n\t\t\t\t\t\t\t2 | \n\t\t\t\t\t\t\t-2 | \n\t\t\t\t\t\t\t13 | \n\t\t\t\t\t\t\t4 | \n\t\t\t\t\t\t\t-2 | \n\t\t\t\t\t\t\t20 | \n\t\t\t\t\t\t\t5 | \n\t\t\t\t\t\t\t5 | \n\t\t\t\t\t\t\t27 | \n\t\t\t\t\t\t\t6 | \n\t\t\t\t\t\t\t6 | \n\t\t\t\t\t\t
7 | \n\t\t\t\t\t\t\t3 | \n\t\t\t\t\t\t\t1 | \n\t\t\t\t\t\t\t14 | \n\t\t\t\t\t\t\t4 | \n\t\t\t\t\t\t\t4 | \n\t\t\t\t\t\t\t21 | \n\t\t\t\t\t\t\t5 | \n\t\t\t\t\t\t\t-5 | \n\t\t\t\t\t\t\t28 | \n\t\t\t\t\t\t\t6 | \n\t\t\t\t\t\t\t-6 | \n\t\t\t\t\t\t
Relationship between Zernike order and azimuthal and radial orders
Zernike polynomials represent aberrations from low to high order with the order number. A wavefront can generally be represented by,
\n\t\t\t\twhere the
The Sun’s heating of land and water masses heat the surrounding air. The buoyancy of air is a function of temperature. So, as the air is heated it expands and begins to rise. As this air rises, the flow becomes turbulent. The index of refraction of air is very sensitive to temperature. Kolmogorov’s model provides a great mathematical foundation for the spatial fluctuations of the index of refraction of the atmosphere. The index of refraction of air is given by,
\n\t\t\t\twhere \n\t\t\t\t\t
\n\t\t\t\t\t
Differentiating the index of refraction with respect to temperature gives,
\n\t\t\t\tFrom Equation (20), we can see that the change in index of refraction with respect to temperature cannot be ignored (Roggemann & Welsh, 1996). These slight variances of temperature, of which the atmosphere constantly has many, will affect the index of refraction enough to affect the resolution of an imaging system.
\n\t\t\t\tAs light begins to propagate through Earth’s atmosphere, the varying index of refraction will alter the optical path slightly. To a fairly good approximation, the temperture and pressure can be treated as random variables. Unfortunately, because of the apparent random nature of Earth’s atmosphere, it can at best be described statistically. It is with this statistical information about a certain astronomical site and the specifications of the telescope that an adaptive optics system can be designed to correct the wavefront distortions caused by the atmosphere at that site.
\n\t\t\t\tThe quantity \n\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\t\t
Plots of the Hufnagel-Valley, SLC-Day, SLC-Night, and Greenwood models for \n\t\t\t\t\t\t\t
Some commonly accepted models of \n\t\t\t\t\t
where \n\t\t\t\t\t
The SLC-Night model is written as,
\n\t\t\t\tThe Greenwood model is written as,
\n\t\t\t\tIn each of these models, \n\t\t\t\t\t
The fact that a wavefront can be expressed as a sum of Zernike polynomials is the basis for Noll’s analysis on how to express the phase distortions due to the atmosphere in terms of Zernike polynomials.
\n\t\t\t\tFried’s parameter, also known as the coherence length of the atmosphere and represented by
where \n\t\t\t\t\t
and is expressed in milli-arcseconds. The isoplanatic angle describes the maximum angular difference between the paths of two objects in which they should traverse via the same atmosphere. This is illustrated in Fig. 4.
\n\t\t\t\tIt is also important to remember that the atmosphere is a statistically described random medium that has temporal dependence as well as spatial dependence. One common simplification is to assume that the wind causes the majority of the distortions, temporally. The length of time in which the atmosphere will remain roughly static is represented by
Illustration of isoplanatic angle
Zernike Mode | \n\t\t\t\t\t\t\tZernike-Kolmogorov residual error | \n\t\t\t\t\t\t
Tip | \n\t\t\t\t\t\t\tΔ1 = 1.0299 (D/r0)5/3 | \n\t\t\t\t\t\t
Tilt | \n\t\t\t\t\t\t\tΔ2 = 0.5820 (D/r0)5/3 | \n\t\t\t\t\t\t
Focus | \n\t\t\t\t\t\t\tΔ3 = 0.1340 (D/r0)5/3 | \n\t\t\t\t\t\t
Astigmatism X | \n\t\t\t\t\t\t\tΔ4 = 0.0111 (D/r0)5/3 | \n\t\t\t\t\t\t
Astigmatism Y | \n\t\t\t\t\t\t\tΔ5 = 0.0880 (D/r0)5/3 | \n\t\t\t\t\t\t
Coma X | \n\t\t\t\t\t\t\tΔ6 = 0.0648 (D/r0)5/3 | \n\t\t\t\t\t\t
Coma Y | \n\t\t\t\t\t\t\tΔ7 = 0.0587 (D/r0)5/3 | \n\t\t\t\t\t\t
Trefoil X | \n\t\t\t\t\t\t\tΔ8 = 0.0525 (D/r0)5/3 | \n\t\t\t\t\t\t
Trefoil Y | \n\t\t\t\t\t\t\tΔ9 = 0.0463 (D/r0)5/3 | \n\t\t\t\t\t\t
Spherical | \n\t\t\t\t\t\t\tΔ10 = 0.0401 (D/r0)5/3 | \n\t\t\t\t\t\t
Secondary Astigmatism X | \n\t\t\t\t\t\t\tΔ11 = 0.0377 (D/r0)5/3 | \n\t\t\t\t\t\t
Secondary Astigmatism Y | \n\t\t\t\t\t\t\tΔ12 = 0.0352 (D/r0)5/3 | \n\t\t\t\t\t\t
Higher orders (J "/ 12) | \n\t\t\t\t\t\t\tΔJ = 0.2944(D/r0)5/3 | \n\t\t\t\t\t\t
Zernike-Kolmogorov residual errors, Δ\n\t\t\t\t\t\t\t\t
where
To make a realization of a wavefront after being distorted by the Earth’s atmosphere, Fried derived Zernike-Kolmogorov residual errors (Fried, 1965, Noll, 1976, Hardy, 1998). The
Time dependence of atmospheric turbulence is very complex to simulate and even harder to generate in a laboratory environment. One common and widely-accepted method of simulating temporal effects of atmospheric turbulence is by the use of Frozen Seeing, also known as the Taylor approximation (Roggemann & Welsh, 1996). This approximation assumes that given a realization of a large portion of atmosphere, it drifts across the aperture of interest with a constant velocity determined by local wind conditions, but without any other change, whatsoever (Roddier, 1999). This technique has proved to be a good approximation given the limited capabilities of simulating accurate turbulence conditions in a laboratory environment. For example, a large holographic phase screen can be generated and may be simply moved across an aperture and measurements can then be made. A sample realization of atmospheric turbulence with a ratio of
A sample phase screen generated via the Frozen Seeing method
In this next section, a new method of generating atmospheric turbulence is introduced. This method takes into account the temporal and spatial effects of simulating atmospheric turbulence with the thought in mind of being able to use this method in a laboratory with a LC SLM. Some advantages of this method include far less computational constraints than using the Frozen Seeing model in software. In addition, the use of Karhunen-Loeve polynomials is introduced rather than using Zernike polynomials, as they are a statistically independent set of orthonormal polynomials.
\n\t\t\tKarhunen-Loeve polynomials are each a sum of Zernike polynomials, however, they have statistically independent coefficients (Roddier, 1999). This is important due to the nature of atmospheric turbulence as described by the Kolmogorov model following Kolmogorov statistics. The Karhunen-Loeve polynomials are given by,
\n\t\t\t\twhere the
and now the wavefront is now represented as a sum of Karhunen-Loeve polynomials with the Zernike-Kolmogorov resitual error weights in the
Tatarski’s model describes the phase variances to have a Gaussian random distribution (Tatarski, 1961). So, by taking Equation (29) and modifying it such that there is Gaussian random noise factored in gives,
\n\t\t\t\twhere
The
where the
Sample vector with a few random numbers with the zero mean unitary Gaussian distribution.
Next, a spline curve is fit to this vector of a few random numbers, shown in Fig. 7, and this spline curve is now the
It has been shown in various experiments that the first order aberrations, ie tip and tilt, are larger in magnitude and vary less with respect to time (Born & Wolf, 1997, Wilcox, 2005). To futher validate the Spline technique, one can take this into account by using a vector of fewer numbers than for the higher order aberrations for tip and tilt and the larger magnitude is taken care of by the Zernike-Kolmogorov residual errors used with the
Sample
Temporal and magnitude difference between (a) tip and tilt and (b) higher order aberrations.
The method of generating atmospheric turbulence with temporal evolution as described in the previous section proposes various advantages compared to the Frozen Seeing model. The computational time to generate a phase screen of atmosphere of size
Seconds to compute an
Simulation of the Frozen Seeing model
Once the phase screen is generated, to be able to simulate the atmospheric turbulence on a SLM with the Frozen Seeing model, a subsection of that image of appropriate size is taken and used at the phase screen to represent the atmosphere at a moment in time. Then, that subsection is drifted across the large phase screen and that represents the next moment in time, to simulate the behavior of wind. This process is repeated until the edge of the
One can clearly see that by generating atmospheric turbulence in this fasion will last for only a few seconds. Increasing the size of the large phase screen,
To compare the Frozen Seeing model to the Spline technique outlined in the previous section, each subsection of the larger phase screen can be analyzed with a single value decomposition (SVD) of the numerical values and calculate the Zernike coefficients,
a) Sample wavefront of atmosphere with
The SVD representation in Fig. 11 (b) of the wavefront in Fig. 11 (a) has a fitted percent error of less than 2%. The
i | \n\t\t\t\t\t\tai | \n\t\t\t\t\t\ti | \n\t\t\t\t\t\tai | \n\t\t\t\t\t
1 | \n\t\t\t\t\t\t-3.74173 | \n\t\t\t\t\t\t13 | \n\t\t\t\t\t\t0.344473 | \n\t\t\t\t\t
2 | \n\t\t\t\t\t\t1.3423 | \n\t\t\t\t\t\t14 | \n\t\t\t\t\t\t-0.09171 | \n\t\t\t\t\t
3 | \n\t\t\t\t\t\t0.384392 | \n\t\t\t\t\t\t15 | \n\t\t\t\t\t\t0.045092 | \n\t\t\t\t\t
4 | \n\t\t\t\t\t\t-0.47419 | \n\t\t\t\t\t\t16 | \n\t\t\t\t\t\t0.179839 | \n\t\t\t\t\t
5 | \n\t\t\t\t\t\t-1.51239 | \n\t\t\t\t\t\t17 | \n\t\t\t\t\t\t0.003466 | \n\t\t\t\t\t
6 | \n\t\t\t\t\t\t0.398136 | \n\t\t\t\t\t\t18 | \n\t\t\t\t\t\t-0.01032 | \n\t\t\t\t\t
7 | \n\t\t\t\t\t\t-0.2772 | \n\t\t\t\t\t\t19 | \n\t\t\t\t\t\t-0.14574 | \n\t\t\t\t\t
8 | \n\t\t\t\t\t\t-0.4476 | \n\t\t\t\t\t\t20 | \n\t\t\t\t\t\t0.052195 | \n\t\t\t\t\t
9 | \n\t\t\t\t\t\t-0.21973 | \n\t\t\t\t\t\t21 | \n\t\t\t\t\t\t0.121335 | \n\t\t\t\t\t
10 | \n\t\t\t\t\t\t0.249914 | \n\t\t\t\t\t\t22 | \n\t\t\t\t\t\t0.354472 | \n\t\t\t\t\t
11 | \n\t\t\t\t\t\t-0.06698 | \n\t\t\t\t\t\t23 | \n\t\t\t\t\t\t-0.18282 | \n\t\t\t\t\t
12 | \n\t\t\t\t\t\t0.267201 | \n\t\t\t\t\t\t24 | \n\t\t\t\t\t\t-0.24076 | \n\t\t\t\t\t
Zernike polynomial coefficients that make up a sample representation of atmosphere with a
The
The
By visual inspection, the two methods simulate atmospheric turbulence in a similar way. A statistical measure of the similarity of these two methods can be described by the cross-correlation of the respective
Zernike order | \n\t\t\t\t\t\tAberration | \n\t\t\t\t\t\tAverage Cross-Correlation | \n\t\t\t\t\t
a2 | \n\t\t\t\t\t\tTip | \n\t\t\t\t\t\t0.7004 | \n\t\t\t\t\t
a3 | \n\t\t\t\t\t\tTilt | \n\t\t\t\t\t\t0.7471 | \n\t\t\t\t\t
a4 | \n\t\t\t\t\t\tFocus | \n\t\t\t\t\t\t0.6686 | \n\t\t\t\t\t
a5 | \n\t\t\t\t\t\tAstigmatism X | \n\t\t\t\t\t\t0.7433 | \n\t\t\t\t\t
a6 | \n\t\t\t\t\t\tAstigmatism Y | \n\t\t\t\t\t\t0.5937 | \n\t\t\t\t\t
a7 | \n\t\t\t\t\t\tComa X | \n\t\t\t\t\t\t0.5981 | \n\t\t\t\t\t
a8 | \n\t\t\t\t\t\tComa Y | \n\t\t\t\t\t\t0.6703 | \n\t\t\t\t\t
a9 | \n\t\t\t\t\t\tTrefoil X | \n\t\t\t\t\t\t0.6909 | \n\t\t\t\t\t
a10 | \n\t\t\t\t\t\tTrefoil Y | \n\t\t\t\t\t\t0.4878 | \n\t\t\t\t\t
a11 | \n\t\t\t\t\t\tSpherical | \n\t\t\t\t\t\t0.5910 | \n\t\t\t\t\t
a12 | \n\t\t\t\t\t\tSec. Astigmatism X | \n\t\t\t\t\t\t0.5277 | \n\t\t\t\t\t
Average cross-correlation values for each
After generating and analyzing ten realizations of atmosphere from the Frozen Seeing method, the average cross-correlation values are summarized in Table 4. An overall average of these cross-correlation values is 0.6381. This shows a consistancy between the generally accepted Frozen Seeing model and the new Spline technique outlined here.
\n\t\tThe Holoeye LC2002 SLM device used in this example is a diffractive device that can directly modulate the phase of an incoming wavefront by π radians. In order to utilize the full 2π radian phase modulation on the impinging wavefront, one can set up a Fourier Filter and use either the +1 or -1 diffractive order through the rest of the system. The graphical user interface (GUI) of the software developed for controlling this system, written in Matlab, can be seen in Fig. 14.
\n\t\t\tGraphical user interface for Holoeye Atmospheric Turbulence System
This software is capable of controlling any LC SLM. The Holoeye LC2002 is a device with 800x600 pixels and can accept a beam of 0.82“ in diameter. This software developed can set up the alignment of the diffraction orders and set alignment biases that may be entered to compensate misalignments in the optical components of the overall system for maximum performance. Different algorithms of generating turbulence can be used if desired and the parameters for the simulated telescope diameter and Fried parameter can control the severity of turbulence, as well. If desired, a secondary annular obscuration can be included in the simulation to simulate a telescope’s secondary mirror.
\n\t\t\tSample (a) and (c) wavefronts and (b) and (d) their corresponding PSFs due to atmospheric turbulence with a 0.4 meter telescope and an
Using the GUI developed, sample atmospheric conditions have been calculated and put on the SLM and then theire PSFs are measured with an imaging camera. The simulated atmospheric turbulence was calculated for a 0.4 meter telescope with seeing conditions having an
The measured PSFs from the wavefronts in Fig. 15 (a) and (c) can be seen in Fig. 16 (a) and (b) and they are similar to that of the calculated PSFs in Fig. 15 (b) and (d), respectively. The 2-dimenstional cross-correlation factors between the two frames and their theoretical components are 0.9589 and 0.8638, respectively, showing that the system performs quite well and the measured and theoretical values are consistent with each other.
\n\t\t\tPSF measurements of the two sample wavefronts in the optical system
PSFs of (a) open-loop and (b) closed loop frame with
At the Naval Research Laboratory, we have developed an AO system for use in astronomical applications (Restaino, S.R., et. al., 2008). We have simulated atmospheric turbulence with the system outlined in the previous sections and caused distortions on a laser beam for our AO system to correct. Simulating fairly reasonable seeing contitions with
\n\t\t\t\tFig. 17 (a) and (b) show the PSFs of a frame taken during open-loop and closed-loop operation with their respective
The method of generating atmospheric turbulence via the Spline technique is virtually the same as the Frozen Seeing method with the added feature of being far less computationally intensive on a computer system. This advantage can be exploited in the development of a software package that can drive any SLM to simulate atmospheric turbulence in almost any wavelength for any telescope diameter and adaptive optical and laser communication systems can be tested for performance evaluations. At the Naval Research Laboratory, a current system is being used with software written in the programming language Matlab and various tests are ongoing. Currently, two SLMs from Holoeye and Boulder Non-Linear Systems are being investigated and various wavelengths are being ustilized for different applications. Future work will include the investigation of other new liquid crystal devices as the field of liquid crystal technology is a very rapidly moving and growing field.
\n\t\tTheoretically, for phosphorus, there is no substitute, there is no element that can replace it [1]. Alfalfa can germinate and grow in agricultural soil containing 0.1% phosphorus, while the plant only contains 0.7% phosphorus in its structure. The structure/activity ratio of phosphorus makes it an important and irreplaceable element for plant growth. To date, there is no known way—natural or synthetic—that can carry out the functions that phosphorus performs. Curiously, in breast-fed infants, the phosphorus such as iron intake is very low [2].
Few centuries ago, phosphorus was chemically identified; however, throughout history, phosphorus has been used in the form of crop residues and manure that were dispersed in agricultural fields. This ancient practice continues so far, but an increase in phosphorus mining throughout the twentieth century contributed, at least initially, to steadily rising agricultural yields, but in the long term, the fertility of agricultural soil is adversely affected. Fertilizers manufactured with high proportions of phosphorus, nitrogen, and potassium boost the plant growth to unprecedented levels, especially in tropical soils that are poor in these constituents [3] although for some reason, nature so provides, and the proof is that these fertilizers, in the long run, contribute to impoverish yields.
In the 1960s, manufactured fertilizer was gearing up farmers to feed more people than the world had ever known; thus, harvests were ahead of a growing population. and although the number of people with malnutrition has decreased, the current figure of 925 million remains worrying [4].
Global production of phosphate rock is now nearly 13 times what it was in 1930s [5]. It has virtues as a key elemental the biochemical of life, but also phosphorus has also earned a well-deserved reputation as a persistent pollutant. In rural areas, unfortunately, phosphates regularly flow into receiving water as runoff from “fertilized” agricultural fields, [6] and in urban areas from sewage sources as a major constituent of human excreta flushed down toilets, as a result of indiscriminate use of phosphates as additives in industrialized food and drinks. Phosphorus can excessively boost local nutrient levels, promoting abnormal algal blooms in the lakes and rivers where it concentrates—a process called eutrophication [7].
Supposedly, this excessive algal growth can eventually lower oxygen levels in the water to the point where some fish species can no longer survive. But the reality is quite the opposite, as algal blooms are triggered precisely by low levels of dissolved oxygen caused in turn by high levels of phosphates. On the other hand, low levels of dissolved oxygen tend to affect marine species until eventually they disappear, regardless of whether there is an overpopulation of algae.
The human eye has 3–4 ml of water that is not rechanged during all the life span of the individual. To practical aims, this is stagnant water; however, this water has adequate dissolved oxygen levels and rarely goes on acidity. We found the biochemical mechanism that Mother Nature uses to maintain the physicochemical characteristics of this eye’s stagnant water in good shape for decades [8].
Melanin splits something previously thought to be unsplittable, and we’ll never look at light, water, Universe, human being, and living things in the same way. The dissociation of the water molecule has transcendent industrial applications, some of them are exemplified in Figures 1–12.
QBLOCK™, a novel material developed based on human eye’s Biology, which also dissociates the water molecules. At left, the container with the presence of QBLOCKS™ explains the abundance of bubbles. The container at right has no QBLOCK™, thereby it has no “bubbles” of oxygen. To date, 5 months later, the bubbles remain in the container with QBLOCK™.
In experiments where QBLOCK™ is applied to offshore sand, after some months, this soil can support plants to grow up. Photograph shows sprouts of a mango seed after 8 days.
After 2 weeks, the sprouts of mango seed. The QBLOCK™ was placed earlier, 14 months ago, and is deep in the offshore sand. Mango seeds were placed 2 weeks ago.
Sprouts of mango seed after 16 days. Notice the QBLOCK™ on the surface.
Mango and avocado sprouts.
Avocado sprout in a soil treated con QBLOCK™.
Mango sprouts, after 21 days. Notice the QBLOCK™ on the soil surface (and deep too).
The presence of QBLOCK™ even in offshore sand, allowed mango seeds germination (right). At center avocado, right: mango sprouts. QBLOCK™ was used in the three specimens.
Left: mango. Right: tamarindo.
The presence of larvae (yellow arrow) in water contaminated with carbon is unusual, due to formaldehyde formation (CH2O), which is toxic. But in the presence of our QBLOCK™, the history is different, beginning with the rise of dissolved oxygen levels, which support life.
In the flask with residues of grains (peanut), but with no other carbon source, only chlorophyll developed on the upper surface of QBLOCK™.
In a closed bottle, simulating a closed system, the presence of QBLOCK™ immersed in the soil sample allows the development of organic carbon. The bottle has been closed since 2016, and a moderate amount of water was added one time only: at the very beginning of the experiment. Photograph taken in January 2022.
Our finding that glucose—and thereafter meals in general—is just the building block of human being but not source of energy because light can be absorbed directly by living things, which suppose their capacity to transform light power into chemical energy in a previously unimaginable split form—like plants; means substantive advances in the fundamental understanding of light and how it behaves inside living things. Thereby, human body is not exception [9].
This is a major paradigm change of how we understand the interaction between light and living things in a way that was not believed to be possible. Not only did we find a new biochemical reaction entity, but it was one that nobody believed could exist [10].
Phosphorus, a 5A element with atomic weight of 31, comprises just over 0.6% of the composition by weight of plants and animals [11]. A ubiquitous mineral on Earth, but not in the universe, and the second most abundant mineral in the human body, phosphorus represents ∼1% of total body weight [12]. Common chemical linkage is in the form of phosphate ester and phosphoanhydride. The element phosphorus is a key element in organic molecules overall in those involved in a wide variety of critical cellular functions. These include the biochemical temperature regulation through the hydrolysis of adenosine triphosphate (ATP), maintenance of genetic information with nucleotides DNA and RNA, intracellular signaling via cyclic adenosine monophosphate (cAMP), and membrane structural integrity via glycerophospholipids. But we keep in mind that energy, defined as everything that produces change, is not only needed to function, to move, reproduce, think, etc., but it is also required even to preserve the shape, the form, and in the case of the molecules and membranes, to continue as such.
The metabolism of inorganic phosphorus (Pi) is acting as a weak acid. At physiological pH of 7.4, Pi exists as both H2PO4(−) and HPO4(2−) and acts as an extracellular fluid (ECF) buffer. Pi is the form transported across tissue compartments and cells. Eighty percent of the body phosphorus is present in the form of calcium phosphate crystals (apatite) that confer hardness to the bone and teeth and function as the major phosphorus reservoir. The remainder is present in soft tissues and ECF. The phosphorus coming from meals and liquids, comprising both inorganic and organic forms, is digested in the upper gastrointestinal tract.
During growth, there is net accretion of phosphorus, and with aging, net loss of phosphorus occurs, in similar way and at the same rate that the capacity of our body to dissociate the water molecule declines. Kidney is the main regulator of ECF Pi concentration by virtue of having a tubular maximum resorptive capacity for Pi (TmPi) that is under close endocrine control that means energy expenditure. It is also the main excretory pathway for Pi surplus, which is passed in urine, thereby requiring energy coming from water dissociation. At a dietary phosphorus of 1400 mg, 1120 mg is absorbed (energy required) in the upper intestine to the ECF, 210 mg returned to the intestine by endogenous secretion, processes all that need energy, resulting in 910 mg net Pi absorption and 490 mg fecal excretion. In the bone, 180 mg is deposited by bone formation and 180 mg return to the ECF by bone resorption, and all involved processes need power. In the kidney, 5040 mg is filtered at the glomerulus and 4130 mg return to the ECF by tubular reabsorption with 910 mg excreted in the urine. In soft tissue, Pi is exchanged between ECF and cells. Let us remember that any chemical reaction, any process, no matter how small, requires energy.
Bioavailability of phosphorus also varies depending on the source. Plant protein sources generally have the lowest bioavailability, followed by animal protein sources, then inorganic phosphate additives with the highest bioavailability. Inorganic phosphates have been nearly 100% bioavailable [13]. Phosphorus from plant-based sources remains less bioavailable than animal sources and animal sources less bioavailable compared with inorganic phosphate additives.
The growing Phosphorous “paradox” (the simultaneous overabundance of P impairing water quality and the prospect of global scarcity of P for future agricultural production) has stimulated new convergence between P-security and water-quality research agenda [14]. In the Universe, phosphorous is notably scarce.
Both in agricultural and urban systems, the fragmentation of the P cycle has implications even for water-quality impairment [15]. A sufficient (adequate for the purpose) and efficient (performing with the least waste of effort) utilization of P may offer a great reduction potential in animal husbandry and crop production [16].
The management of animals plays a key role in reducing P inputs to soils and, consequently, P losses from arable lands and grasslands. Because of the regional concentration of animal husbandry, improved diets with less P content may be most urgently required and effective in regions with high stocking density.
Genes involved in pathways relevant for P utilization were differentially expressed due to variable P supply. Phosphorous fluxes through various process and ecosystems along which originally mined and processed P is diluted and distributed over increasingly large parts of the terrestrial and aquatic environments.
Animals fed with low-P diets showed attempts to maintain mineral homoeostasis via intrinsic mechanisms [17]. Pyrophosphatase, an enzyme, could completely exchange the oxygen atoms within the phosphate ion with oxygen atoms originally within water molecules [18]; however, water does not release oxygen for free, so it is necessary to dissociate the molecule (of water) first. The isotopic composition of oxygen (proportion of Oxygen 16 to Oxygen 18) within phosphate ions in plant leaves was different from that observed in the solution delivering P to the plant [19], which suggests that inside living things, atomic nucleus tends to grow, but it does not happen in a flask solution. The difference is the available energy inside the living thing can impel protons (H+) with enough and adequate force, so the atomic nucleus of oxygen and other elements increase their atomic number.
With the adequate surroundings, and a precise and enough energy, it is possible to create the main elements of periodic table contained in living things. Supposedly, only a synchrotron can impel subatomic particles with enough speed to be included in atomic nuclei. However, Nature can do it inside cells of living things.
For instance, Hydrogen has an atomic number of 1 and atomic mass of 1. Thereby Hydrogen has no neutrons. The difference between Carbon (6), Nitrogen (7), and Oxygen (8) is one and two protons, respectively.
The internal cellular environment has a relative abundance of Hydrogen and Oxygen (and energy) coming from water dissociation. Therefore, we can enlist Hydrogen, Carbon, Nitrogen, Oxygen, Sodium, Magnesium, Phosphorous, Sulfur, Chlorine, and Calcium as primary elements normally present in living things.
Now, we’ll enlist the same elements with the number of protons in their atomic nuclei. H (1), C (6), Nitrogen (7), O (8), Na (11), Mg (12), P (15), Sulfur (16), Cl (17), K (19), and Ca (20).
Notice that the difference between them is just one proton, in general terms. Thereby, the formation inside living things of Carbon con atomic mass of 14, and Oxygen con atomic mass of 18, means that atomic nuclei can grow inside living cells. After death, Carbon 14, and Oxygen 18, tends to fade gradually along thousands of years.
This is, the growth of atomic nuclei of Carbon and Oxygen can occur inside the cell, because water dissociation happens there, so protons and energy, the two key elements, are available. Furthermore, these transformations—in guarded proportions—can also occur between Na (11) and Mg (12; between P (15) and S (16); also, between Cl (17), K (19), and Ca (20).
It is possible that a certain degree of transmutation between these elements happens to adjust the requirements of the living beings, allowing them a better adaptation to their surroundings. Thereby, Life is not totally dependent on determined diet, it can hatch under diverse diet composition, because the human body can synthesize chemical elements—guarded proportions—and compensate for nutritional deficiencies in the environment at any given time.
In relation to the essential trace elements, we have Manganese (25Mn), Iron (25Fe), Cobalt (26Cu), Nickel (27Ni), Copper (29Cu), and Zinc (30Zn) as examples of chemical elements whose difference between them is a proton, that is: a hydrogen without electron, and the dissociation of water produces them—electrons—abundantly [20].
Supplements are not the answer, i.e.: the intake of calcium supplements in patients with osteoporosis makes their bones brittle.
Remarkable abundance of phosphorous on Earth and its scarcity in the Universe suggest strongly that the P could be formed by living beings overall those in soil. Phosphorus is widely distributed in the global food supply, with milk and dairy being the greatest contributors followed by meat and poultry. Notice a strong relationship with living beings. Circadian fluctuations in some bioactive components and trace elements are suggested to transfer chronobiological information from mother to child to assist the development of the biological clock [21].
For dairy cows, mineral P supplementation of the feed is generally not necessary and might be needed only when fed with high amounts of corn products. This includes more precise prediction of the dietary P requirement and a better characterization of the availability of different P sources used in animal feed [22].
About nonruminants, much attention has recently been given to the variation in plant P sources, in particular phytate-P [23]. It has been known for about two decades that the use of the enzyme phytase as a feed additive can effectively increase phytate-P availability in pigs and poultry. However, enzymes do not make possible an impossible reaction.
Sophisticated analytical techniques such as stable isotope techniques (33-P, 18-O), NMR- and synchrotron-based spectroscopies are required for quantifying P cycles, fluxes, and dynamics in the soil and other environmental systems.
Measurement of the isotopic composition of oxygen within the phosphate ion can improve our understanding of P cycling in soil and plant systems [24]. Analyzing the isotopic composition of oxygen bound to P (δ18O-P) is, however, constrained by several analytical difficulties [25].
The scientific discussion on the identification of soil organic P forms—whether soils contain simple well-identifiable organic P forms or organic P in complex macromolecular, nonidentified structures—is continuing [26]. The cycles of the biogeochemically important nutrient elements C, N, and P are closely interlinked across environmental systems.
The difference between Silicium (14) and Phosphorous (15) is just one proton, and microorganisms in soil also can dissociate the molecule of water, thereby, inside them, there are available protons and energy. Neutrons form spontaneously.
The C-, N-, P-stoichiometry of soil organic matter was primarily controlled by soil properties rather than by the elemental stoichiometry of manure or fertilizer inputs [27]. Since 1998, in Northern Germany, organic P forms in soil did not correspond with the P forms in the organic fertilizers applied to the soil [28]. It is quite possible that living organisms inside soil make the difference, given the energy, protons, and oxygen available coming from water dissociation in analogue fashion to formation of 14 C and 18 O in living beings.
Although the study of C-, N-, and P ratios is needed to understand the long-term functioning of cropped soils, it must always be tied with valuation of elemental inputs and budgets, and the capability of soils to steady, modify, and form, even a subatomic level, the C-, N-, and P-containing compounds. The soil is way beyond to be inert.
The relative importance of P fluxes arising from soil organic matter (SOM) mineralization compared with fluxes from P desorption appears to be much larger in forest and grassland than in arable soils [29], which is understandable and expected because the intensive use of agrochemicals in arable soil, and not in forest and grassland, perturbed the astonishingly accurate dissociation of the water molecule, therefore the highly ordered generation and distribution of energy, protons, and oxygen are impoverished.
Factors such as wetting and drying cycles, green manure inputs, seasonal fluctuations, amount of light, pressure, temperature, moisture, and soil parent material also clearly affect organic P mineralization [30].
The application of microbial inoculants as so-called biofertilizers has often been described as a component of sustainable nutrient management. The main efforts in this field have focused on living beings, as fungi [31].
Considering the uncertainty and the costs of microbial inoculants in practical agriculture, the activation of native soil microorganisms by agronomic measures such as organic matter management and crop rotation could be a better approach to utilize benefits of microbes [32] measures that significantly diminishing the need and use of industrialized phosphorous.
Fertilizers manufactured with high proportions of phosphorus, nitrogen, and potassium boosted plant growth to unprecedented levels, especially in tropical soils that are poor in these constituents [33]. Although phosphorus is one of the most common elements on Earth, only a small percentage is available for human use [34]. Phosphorus is seldom credited for the decline in the number of undernourished people, but such progress would have been unthinkable without its dramatically expanded use in the form of phosphate-based fertilizer.
Phosphorus plays many roles in society today—both desired and undesired [35]. Phosphorus brings about a plentiful of different functions—on immeasurably dissimilar temporal and geographical balances: transporting split-second signals to the brain in the chemical ATP, or immobile as a Ca3 (PO4)2 molecule in apatite-rich phosphate rock that took tens of millions of years to form, expecting mining, or progressively being drawn up from soil solution by plant roots via chemical dissemination, or clearing from our bodies in a momentary drop of urine before being thinned by a flood of flush water to join other domestic and industry wastewater at a distant and pestilent treatment plant, poisoning water bodies as cyanobacteria, or simply cycling naturally between land, biota, and water without being perceived by most of the society [36].
Elevated P inputs can have severe long-term effects on freshwater and marine ecosystems, and large-scale efforts are needed to reduce P inputs from land. Eutrophication is still considered to be the most serious anthropogenic threat, for instance, in the dead zone of Baltic Sea [37]. The mitigation of eutrophication in freshwater, coastal, and marine systems requires a better understanding of mobilization and release of P from soil and catchments (soil-to-water transfers), P composition and cycling in water bodies, and measures to decrease P loss.
Despite its merits as an essential staff of life, phosphorus has also a role as quite persistent pollutant. In rural areas, with poor control of agrochemicals, it often flows into receiving water (ponds, lakes, rivers, etc.) as runoff from agricultural fields and in urban areas from dirt sources as a foremost component of human body waste flushed down toilets [38]. Phosphorus can excessively boost some type of biochemical reactions meanwhile turn down others, which finally seems as endorsing and abnormal algal blooms in the lakes, ponds, and rivers where it concentrates—eutrophication [39].
The misconception that disproportionate algal growth can in the long run lower oxygen levels in the water although first the levels of dissolved oxygen fall and then it is eutrophication, it is thought that some fish species cannot tolerate this DOL of less of 6 mg/l. Thereby, the explanation of this long-lasted mistake emerges after our discovery that both prokaryotic and eukaryotic cells are phototrophs [40].
It has been demonstrated that the phosphate detergents emerging from municipal wastewater streams were a major driver of Lake Erie’s problem—excessive algal growth and mortality of some fish’s species [41].
Cadmium is a well-established renal, bone, and pulmonary toxicant that occurs naturally in phosphate rock deposits. Phosphate fertilizers are considered the main source of cadmium in agricultural soils [42].
In some river basins, P export now exceeds P inputs, which may result from the net mobilization of P pools accumulated during earlier decades [43], already reached a finite P-accumulation stage. Animal studies show that high inorganic phosphate feeding resulting in high serum phosphate promoted lung, skin, bladder, and prostate cancer [44].
Leaf senescence, or the final developmental stage of the leaf, means the transition from a photosynthetically active organ to the attenuation of said function and eventual death of the leaf. During senescence, essential nutrients sequestered in the leaf, such as phosphorus (P), are recycled, this is mobilized and transported to sink tissues, particularly expanding leaves and developing seeds. Phosphorus recovery is decisive, as it helps to ensure that previously acquired P is not lost to the environment, particularly under the naturally desirable occurring condition where most unfertilized soils contain low levels of soluble orthophosphate (Pi), the only form of P that roots can directly assimilate from the soil [45].
Phosphorus (P) is a key plant macronutrient, as it is a structural component of critical biomolecules involved in both temperature regulation processes, such as ATP and PPi, and in the development of key macromolecules such as nucleic acids and phospholipids. Thus, P is central to nearly all foremost metabolic processes in plants (and humans), including photosynthesis and respiration. Soluble orthophosphate (PO43−; Pi), which is the only form of plant-available P that roots can directly assimilate from the soil, is often highly limiting in the natural environment, prompting the widespread erroneous use of Pi-containing fertilizers in agriculture [46]. And we say wrong because the living entities that live in the clay can transmute the phosphorus from the silicon, because the difference between them is just one proton.
While fertilizers are seemingly effective in boosting harvest yields, only 15–30% of applied P is on average absorbed by crops in the year of its application [47]. The resulting Pi-runoff from fertilized fields leads to nutrient overloading of aquatic ecosystems, triggering toxic algal blooms and eutrophication of the affected waterways. Furthermore, the Pi contained within these fertilizers is manufactured from nonrenewable rock-phosphate reserves, which have been projected to be depleted within the next 80 years [48].
The use of fertilizers in agricultural practices may boost efficient crop growth but could consequently inhibit efficient Pi recycling and thus the overall P-use efficiency (PUE) [49]. Nearly half of the total P present within a healthy leaf exists within nucleic acids; of that, approximately 80% is represented by ribosomal RNA (rRNA).
The possibility of microorganisms in soil can synthesize 15P arising from 14Si opens an unexpected source of phosphorous in minute quantities but at the same time sufficient for the fundamental biochemical needs of life, both in plants and animals. The difference between them (15P and 14Si) is just one proton, and water dissociation provides enough protons, energy, and high-energy electrons. As it is expected, amount of Pi resulting from this “transmutation” of elements are small, such as 14C and 18O, which also formed—in small quantities—inside living things, and coherently, the plants metabolism is so efficient to recycling minute amounts of Pi.
Therefore, the fertility of the soil depends significantly on its oxygen content, so much so that the formation of clays depends on the presence of oxygen and therefore on the presence of life that generates it, rather than phosphorus in irrational quantities. If we restore the oxygen levels that the arable soil should contain, soil fertility would improve significantly. And even more so if we irrigate the crops with water with dissolved oxygen levels above 6 mg / L.
Enzymes do not make possible an impossible reaction, thereby, neither water dissociation nor transmutation from 14Si to 15P is a biochemical reaction that depends on enzymatic activity. Thereby, Pi acquisition from the soil is not an entirely passive process due to soil’s microorganisms being systems with capacities way beyond our abstraction capacity.
Zones that were found to have high heavy metal levels should be avoided to cultivate potatoes because potatoes tend to accumulate heavy metals notably higher than other types of plants. Soils that were found to be acidic traditionally should be treated with lime so that heavy metal uptake by plants via soil–plant pathway could be slowed; however, the increase of oxygen levels in the soil and the increase of pH through QBLOCK™ improve the root plant health and thereby the crops yield. It is important to protect groundwater resources in the region from heavy metal contamination especially in acidic zones [50].
Phosphate extraction increasingly generates more pollution and waste, requires more energy per nutrient value, and costs more to mine and to process [51]. The fluxes that we generate are larger than natural fluxes. This is no easy way to run a bio-geo-chemical cycle [52].
First life originated in water, then glucose—the universal precursor—and thereafter phosphorus that plays important role in evolution of whole spectrum of life. Phosphorus constitutes integral part of nucleic acids and amino acids, which are carriers of the whole genetic information of evolution of life on this planet and building block in every form of life. Such is importance of element phosphorus. But now phosphorous is emerging hidden crisis before agricultural community and environmentalists of the world.
Phosphates are thermodynamically unstable while being kinetically stable [53]. ATP is kinetically stable under physiologic conditions [54]. Kornberg has estimated that eukaryotic cells contain on average 109 molecules of ATP [55]. Theoretically, ≈2.5 ATPs are formed for each pair of electrons sent by an NADH molecule down the respiratory chain and that ≈80 kg of ATP is turned over in a day per adult male human, thereby, about 30 kg of NADH must be generated and funneled to O2 every day. It does not make sense.
The fluidity of nucleoside triphosphates, via NMP allocation, to handle DNA replication (~2 × 108 ATP to replicate the
In cancer cells and in pluripotent stem cells (embryonic), TCA cycle is not fully active for purposes of ATP synthesis, even in the presence of ample oxygen. Thus, they do not oxidize glucose completely, and electrons do not get put into the mitochondrial respiratory chain effectively, the so-called Warburg effect [57].
Phosphorous is an inorganic element probably produced by photosynthesis in living beings. O2 by analogy is an inorganic molecule also, since nearly all the 20% of the earth’s atmosphere that is O2 has been biogenically derived via O2-producing photosynthesis.
O2: Thermodynamically Activated, Kinetically Stable Inorganic Molecule to Power Eukaryotic Metabolism. Molecular oxygen is a difficult to handle metabolite. Living things have optimized their presence, as it has been present in the equation since the beginning of time. But the valuable product of water dissociation is hydrogen, simply because it is the quintessential energy carrier in the entire universe. Therefore, the following concepts are totally theoretical: Higher eukaryotes unlock its thermodynamic potential to undergo four-electron reduction and make a good living energetically. But glucose is not a source of energy, it is only a source of biomass, even if it is combined with oxygen. They practice substrate hydroxylation chemistry judiciously, in hypoxia, in macromolecule demethylations, and in the steroid hormone maturation pathways. Of course, oxygen appears in every reaction but its “unwanted” presence is since it comes from the dissociation of water that the body carries out to obtain energy. The oxygen that the body contains does not come from the atmosphere. Yet, they still had to evolve enzymatic and nonenzymatic defenses against toxic partially reduced oxygen metabolites, emphasizing how oxygen reductive metabolism has its intrinsic dangers. The previous paragraph, also theoretical, will have to be rewritten since the best antioxidant known is hydrogen.
The amount of ATP in a 70 kg human has been estimated at ~50 g, with about 109 molecules/cell.
The most common single posttranslational modification of proteins (PTM) is phosphorylation of Ser, Thr, and Tyr side chains by ATP-dependent protein kinases, but the activation energy required by enzymes comes from the dissociation of water, the effect of ATP is minor and complementary. Supposedly tens to hundreds of thousands of phosphor variants of proteins may be formed transiently in human cells by the >500 members encoded in human kinemes; however, the energy that the body obtains through the dissociation of water is exact, amazingly accurate, and has not changed since the beginning of time, so the sequence of biochemical logic with which the body handles the compounds that conform us is strictly regulated by 4 billion years of evolution. Many proteins can be phosphorylated at multiple residues, by single or multiple kinases, but it does not happen randomly, but every kinase requires energy that comes from the dissociation of the water molecule. The fraction of a given protein subject to modification can depend on location within the cell (distinct pools) available energy that comes from water dissociation and the activity of the PTM enzymes. Hundreds to thousands of fractional molecular protein variants can be created (but not randomly) and then returned to starting pools by protein phosphatases [58], which, to function properly, require adequate energy, which undoubtedly comes from the dissociation of the water molecule. By the way, any enzyme whether related to phosphate metabolism requires the energy that always comes from water dissociation. Thereby, the turnover rate of the splitting of the water molecules is the great regulator of the functioning of the biochemical logic of life both in water and in agricultural soil.
There are at least four compounds that seem to exist in abundance on planet Earth in comparison with other planets or with known Universe: oxygen, water, clay, and phosphorous.
Them all are produced by living beings. This is: the presence of these compounds and elements requires the presence of life to be produced. Without life, they are not produced or at least are absent.
Such as the O2 present inside human body coming from water dissociation that living being has inside and not from atmosphere [59], then a significant part of phosphorous coming from the inner photosynthesis more than of diet. Phosphate esters and anhydrides dominate the living world but are seldom used as intermediates by organic chemists. Phosphoric acid is specially adapted for its role in nucleic acids because it can link two nucleotides and still ionize, something unique; the resulting negative charge serves both to stabilize the diesters against hydrolysis and to retain the molecules within a lipid membrane; but these reactions also need the power coming from water dissociation. Phosphates with multiple negative charges can react through energy expenditure, by way of the monomeric metaphosphate ion PO3- as an intermediate. No other residue appears to fulfill the multiple roles of phosphate in biochemistry; however, energy from water dissociation still is needed. Stable, negatively charged phosphates react under catalysis by enzymes—energy expenditure; organic chemists, who can only rarely use enzymatic catalysis for their reactions, need more highly reactive intermediates than phosphates.
Given our discovery of unexpected intrinsic capacity of living beings to transform sunshine power into chemical energy, through water dissociation, like plants do, we can discard the role of phosphates as energy sources [60] limiting it to temperature regulation ATP, ADP, and AMP cycle, the biology of phospho-nucleotides, and control of phosphates toxicity.
Therefore, the planetary boundary for phosphorous must be rethanked, rewritten, [61] because the abundance of phosphorous on Earth and the scarcity in Universe are not by chance. Phosphorous (15P) is produced by living things, mainly by the microorganisms of the soil; probably arising from silicium (14Si). Remember that the difference between them is just one proton, and the transformation of sunshine power into chemical energy is through the dissociation of the water molecules, a universal mechanism that places the adequate energy, protons, and oxygen inside every cell of living things.
Therefore, while the life thrives on planet Earth, Phosphorous should be produce by living things, as has been done since beginning of time. And it is important to respect the way nature has formed and used it, this is in minimal quantities. The secret of sustainable fertile soil lies in keeping oxygen levels high inside it; something that is possible to achieved with the QBLOCK™.
Once the knowledge about the unsuspected ability to dissociate water from living beings, to transform sunlight into chemical energy, is known and disseminated sufficiently, the use of nitrogen fertilizers can be reduced to a minimum and even stop using them completely, because the damage it causes to the environment, even from their manufacture and subsequent use, they are huge and long-lasting.
We can maintain the fertility of agricultural soil by raising the levels of oxygen it contains and irrigating crops with water with adequate levels of dissolved oxygen, this is above 6 mg/L. This would substantially reduce the need for artificial fertilizers whose synthesis alone is remarkably polluting, not to mention the amounts of phosphates that are thrown into crops and end up flowing in rivers and seas forming dead zones, as in the Gulf of Mexico, in the Gulf of Aden, the Baltic Sea, which continue to spread.
The use of QBLOCK™ or some similar method that raises the levels of dissolved oxygen in both water and agricultural soil will allow us a more rational agriculture, even regenerative, because we will be able to prevent the damage inflicted by current agrochemicals, and even reverse it.
This work was supported by Human Photosynthesis™ Study Centre. Aguascalientes 20000, México.
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Delac received his B.Sc.E.E. degree in 2003 and is currentlypursuing a Ph.D. degree at the University of Zagreb, Faculty of Electrical Engineering andComputing. His current research interests are digital image analysis, pattern recognition andbiometrics.",institutionString:null,institution:{name:"University of Zagreb",country:{name:"Croatia"}}},{id:"557",title:"Dr.",name:"Andon",middleName:"Venelinov",surname:"Topalov",slug:"andon-topalov",fullName:"Andon Topalov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/557/images/1927_n.jpg",biography:"Dr. Andon V. Topalov received the MSc degree in Control Engineering from the Faculty of Information Systems, Technologies, and Automation at Moscow State University of Civil Engineering (MGGU) in 1979. He then received his PhD degree in Control Engineering from the Department of Automation and Remote Control at Moscow State Mining University (MGSU), Moscow, in 1984. From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. 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Hammad Ather",coverURL:"https://cdn.intechopen.com/books/images_new/5516.jpg",editedByType:"Edited by",editors:[{id:"88868",title:"Prof.",name:"M Hammad",middleName:null,surname:"Ather",slug:"m-hammad-ather",fullName:"M Hammad Ather"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],booksByTopicTotal:4,seriesByTopicCollection:[],seriesByTopicTotal:0,mostCitedChapters:[{id:"54132",doi:"10.5772/67473",title:"Cross-Polarization OCT for In Vivo Diagnostics and Prediction of Bladder Cancer",slug:"cross-polarization-oct-for-in-vivo-diagnostics-and-prediction-of-bladder-cancer",totalDownloads:1119,totalCrossrefCites:1,totalDimensionsCites:3,abstract:"This chapter contains three parts covering recent efforts to increase the accuracy of optical coherence tomography (OCT) differential diagnostics of bladder pathologies. The first part compares the diagnostic efficacy of traditional OCT and cross-polarization OCT (CP OCT); CP OCT and fluorescence cystoscopy (FC) for detecting flat lesions in the bladder at the early stages of cancer. The second part contains a report on achievements in application of CP OCT for detection of recurrent carcinoma in the scar area that is a hardly distinguishable form of bladder cancer using an optimized CP OCT image analysis. The third part of the chapter reviews the results on CP OCT usage for in vivo diagnosis of the bladder cancer after radiation therapy of cervical cancer.",book:{id:"5516",slug:"bladder-cancer-management-of-nmi-and-muscle-invasive-cancer",title:"Bladder Cancer",fullTitle:"Bladder Cancer - Management of NMI and Muscle-Invasive Cancer"},signatures:"Elena Kiseleva, Gladkova Natalia, Streltzova Olga, Kirillin Mikhail,\nMaslennikova Anna, Dudenkova Varvara, Yunusova Katerina and\nSergeeva Ekaterina",authors:[{id:"68196",title:"Prof.",name:"Natalia",middleName:null,surname:"Gladkova",slug:"natalia-gladkova",fullName:"Natalia Gladkova"},{id:"191970",title:"Dr.",name:"Elena",middleName:null,surname:"Kiseleva",slug:"elena-kiseleva",fullName:"Elena Kiseleva"},{id:"191990",title:"Dr.",name:"Olga",middleName:null,surname:"Streltzova",slug:"olga-streltzova",fullName:"Olga Streltzova"},{id:"191992",title:"Mrs.",name:"Varvara",middleName:null,surname:"Dudenkova",slug:"varvara-dudenkova",fullName:"Varvara Dudenkova"},{id:"191993",title:"Prof.",name:"Anna",middleName:null,surname:"Maslennikova",slug:"anna-maslennikova",fullName:"Anna Maslennikova"},{id:"191994",title:"Dr.",name:"Katerina",middleName:null,surname:"Yunusova",slug:"katerina-yunusova",fullName:"Katerina Yunusova"},{id:"191995",title:"Dr.",name:"Mikhail",middleName:null,surname:"Kirillin",slug:"mikhail-kirillin",fullName:"Mikhail Kirillin"},{id:"193422",title:"Dr.",name:"Ekaterina",middleName:null,surname:"Sergeeva",slug:"ekaterina-sergeeva",fullName:"Ekaterina Sergeeva"}]},{id:"54019",doi:"10.5772/67309",title:"Bladder Cancer Markers and Recent Innovations",slug:"bladder-cancer-markers-and-recent-innovations",totalDownloads:1702,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"Bladder cancer (urothelial carcinoma) is the most common tumor of the urinary tract. It occurs more frequently among men about 65 years old on average. Two forms of the tumor are known: a non–muscle-invasive one and a muscle-invasive one. The latter turns out to be very aggressive with a survival of 5 years average. The non–muscle-invasive form frequently recurs (60–70%) and in 15% of cases, it progresses into the invasive form. The diagnosis is made mainly by cystoscopy and urine cytology. A high number of researches were dedicated in order to find a simple test using voided urine to frequently monitor possible tumor recurrence. During the last 10 years, many tests were proposed concerning either special proteins of which the most common are the bladder tumor antigen (BTA) and the nuclear matrix protein 22 (NMP22) or the presence of genetic mutations [most frequently, fibroblasts growth factor receptor 3 (FGFR3) and TP53], alteration of DNA methylation, chromatin structure and, more recently, the presence of specific micro-RNA. Recently the analysis of lipids present in voided urine showed a difference in fatty acids between healthy individuals and those affected by non-invasive forms. These markers appear to have a high specificity and sensitivity: a deepening of these results could lead to the development of a test that avoids invasive treatment and the cost of cystoscopy.",book:{id:"5516",slug:"bladder-cancer-management-of-nmi-and-muscle-invasive-cancer",title:"Bladder Cancer",fullTitle:"Bladder Cancer - Management of NMI and Muscle-Invasive Cancer"},signatures:"Mariapia Viola-Magni, Samuela Cataldi and Daniela Marocco",authors:[{id:"192375",title:"Prof.",name:"Mariapia",middleName:null,surname:"Viola-Magni",slug:"mariapia-viola-magni",fullName:"Mariapia Viola-Magni"},{id:"197851",title:"BSc.",name:"Samuela",middleName:null,surname:"Cataldi",slug:"samuela-cataldi",fullName:"Samuela Cataldi"},{id:"197852",title:"Dr.",name:"Daniela",middleName:null,surname:"Marocco",slug:"daniela-marocco",fullName:"Daniela Marocco"}]},{id:"54063",doi:"10.5772/67280",title:"Intravesical Chemohyperthermia for NMIBC: Rationale and Results of This Developing Treatment",slug:"intravesical-chemohyperthermia-for-nmibc-rationale-and-results-of-this-developing-treatment",totalDownloads:1395,totalCrossrefCites:0,totalDimensionsCites:1,abstract:"Bladder cancer is the fourth most common cancer in men, and the lifetime risk of getting bladder cancer is 2.4%. Approximately 75% of newly diagnosed cases of bladder cancer are non-muscle-invasive bladder cancer (NMIBC), and half of them will show recurrence and/or progression after transurethral resection. Therefore, after transurethral resection, in high-risk patients, intravesical therapy is mandatory. However, bacillus Calmette-Guérin (BCG) is associated with important side effects such as systemic tuberculosis and bladder retraction. Chemohyperthermia (CHT) has shown a 60% lower recurrence rate than standard mitomycin C (MMC). However, its effectiveness in high-risk patients, especially CIS and BCG refractory patients, is even more important. CHT will probably be an option for patients unsuitable for radical cystectomy or those on whom BCG can’t be used. Two main technologies are currently available for intravesical CHT: microwaves and recirculating heated fluids. Both of them have pros and cons that should be known and evaluated by a urologist. In this chapter, we will speak about rationale, technical options, clinical results, ongoing studies, and future perspective for this interesting treatment option for intermediate and high-risk patients with NMIBC.",book:{id:"5516",slug:"bladder-cancer-management-of-nmi-and-muscle-invasive-cancer",title:"Bladder Cancer",fullTitle:"Bladder Cancer - Management of NMI and Muscle-Invasive Cancer"},signatures:"Sousa-Escandón Manuel Alejandro, Flores Carbajal Javier, Sousa-\nGonzález Daniel and Rodriguez Gómez Silvia",authors:[{id:"191356",title:"Dr.",name:"Alejandro",middleName:null,surname:"Sousa-Escandón",slug:"alejandro-sousa-escandon",fullName:"Alejandro Sousa-Escandón"}]},{id:"54147",doi:"10.5772/67443",title:"Lymphadenectomy in Muscle Invasive Bladder Cancer",slug:"lymphadenectomy-in-muscle-invasive-bladder-cancer",totalDownloads:1273,totalCrossrefCites:0,totalDimensionsCites:1,abstract:"Bladder cancer is the second most common genitourinary malignancy with urothelial cancer comprising nearly 90% of primary bladder tumors. Urothelial carcinoma of the urinary bladder is the fifth most common malignancy in the United States, with an estimated 76,960 new cases and 163,900 deaths in 2016. Radical cystectomy with lymph node dissection remains the standard treatment for patients with muscle-invasive urothelial carcinoma of the bladder, and also for nonmuscle-invasive disease, refractory to intravesical therapy. The current approaches to pelvic lymph node dissections are based on the removal of lymph nodes most commonly harboring metastatic disease, notably the external iliac, obturator, and hypogastric lymph nodes. The boundaries for a standard pelvic lymph node dissection generally include the bifurcation of the common iliac vessels superiorly and the genitofemoral nerve laterally. Extended pelvic lymph node includes the removal of lymph nodes between the bifurcation of the common iliac vessels and the level of the aortic bifurcation, sometimes including distal aortic and caval nodes up to the level of the inferior mesenteric artery, as well as presacral nodes. Extended and superextended dissection has been reported to be associated with superior survival outcome.",book:{id:"5516",slug:"bladder-cancer-management-of-nmi-and-muscle-invasive-cancer",title:"Bladder Cancer",fullTitle:"Bladder Cancer - Management of NMI and Muscle-Invasive Cancer"},signatures:"Mustafa Ozan Horsanali and Kutan Ozer",authors:[{id:"59702",title:"Dr.",name:"Mustafa Ozan",middleName:null,surname:"Horsanali",slug:"mustafa-ozan-horsanali",fullName:"Mustafa Ozan Horsanali"},{id:"192699",title:"Dr.",name:"Kutan",middleName:null,surname:"Ozer",slug:"kutan-ozer",fullName:"Kutan Ozer"}]},{id:"59222",doi:"10.5772/intechopen.73515",title:"Development of Oncolytic Adenoviruses for the Management of Prostate Cancer",slug:"development-of-oncolytic-adenoviruses-for-the-management-of-prostate-cancer",totalDownloads:1121,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"Prostate cancer (PCa) is the fifth most common cause of cancer-related deaths in men globally. Androgen receptor (AR) signalling plays a vital role in initiation and progression and antiandrogens are standard of care first-line therapeutics. However, resistance frequently develops resulting in metastatic castration-resistant prostate cancer (mCRPC). Management of CRPC is currently chemotherapy and/or radiotherapy but is mostly palliative due to rapid development of resistance. The need for novel approaches to eliminate mCRPC is compelling; a promising option is replication-selective (oncolytic) adenoviruses with demonstrated efficacy in preclinical models of multidrug-resistant PCa. The safety of various viral mutants has been confirmed in numerous clinical trials with minimal toxicity in patients. Importantly, oncolytic adenoviruses synergise with the current standard of care for mCRPC even in treatment-resistant cells. In early phase I–II clinical trials, promising efficacy in patients with localised PCa was reported after intratumoural administration, and phase III trials are underway. To enable systemic delivery, for targeting of mCRPC, further developments are necessary because of the short half-life of the adenoviral mutants in human blood. Current progress in preventing the high-affinity binding of adenovirus to erythrocytes, hepatocyte uptake, and elimination by hepatic Kupffer cells will be described.",book:{id:"6423",slug:"prostate-cancer",title:"Prostate Cancer",fullTitle:"Prostate Cancer"},signatures:"Ahmed A. Ali and Gunnel Halldén",authors:[{id:"80427",title:"Dr.",name:"Gunnel",middleName:null,surname:"Hallden",slug:"gunnel-hallden",fullName:"Gunnel Hallden"},{id:"232386",title:"MSc.",name:"Ahmed",middleName:null,surname:"Ali",slug:"ahmed-ali",fullName:"Ahmed Ali"}]}],mostDownloadedChaptersLast30Days:[{id:"70881",title:"Robot-Assisted Partial Nephrectomy: Evolving Techniques",slug:"robot-assisted-partial-nephrectomy-evolving-techniques",totalDownloads:494,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"Robotic-assisted partial nephrectomy is now embraced in urology as a recommended treatment option for small localised renal tumours. There is an increasing trend towards setting up robotic-assisted services in urological centres across the world. Our aim is to review the available published common robotic-assisted partial nephrectomy techniques. We present our institutions’ established step-by-step technique for performing robotic-assisted partial nephrectomy, in order to guide aspiring urologists interested in performing robotic-assisted partial nephrectomies. The importance of pre-operative review of imaging in a multi-disciplinary approach is critical. 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The first part compares the diagnostic efficacy of traditional OCT and cross-polarization OCT (CP OCT); CP OCT and fluorescence cystoscopy (FC) for detecting flat lesions in the bladder at the early stages of cancer. The second part contains a report on achievements in application of CP OCT for detection of recurrent carcinoma in the scar area that is a hardly distinguishable form of bladder cancer using an optimized CP OCT image analysis. 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In this chapter, specifically, genetic alterations playing role in the prostate cancer are intended to be reviewed briefly under the subheadings of genomic instability and the hallmarks of cancer which are sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling the replicative immortality, inducing angiogenesis, activating invasion and progression to metastatic disease, reprogramming of the energy metabolism and evading immune destruction.",book:{id:"6423",slug:"prostate-cancer",title:"Prostate Cancer",fullTitle:"Prostate Cancer"},signatures:"Hikmet Köseoğlu",authors:[{id:"111496",title:"Dr.",name:"Hikmet",middleName:null,surname:"Köseoǧlu",slug:"hikmet-koseolu",fullName:"Hikmet Köseoǧlu"}]},{id:"54587",title:"Genital Organs‐Sparing Radical Cystectomy in Female Patients with Muscle Invasive Urothelial Carcinoma of the Bladder",slug:"genital-organs-sparing-radical-cystectomy-in-female-patients-with-muscle-invasive-urothelial-carcino",totalDownloads:1296,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"There has been considerable interest in urethral‐sparing cystectomy and preservation of the gynecological tract to maintain continence mechanism, sexual function, and reproductive function in young patients who undergo radical cystectomy for muscle‐invasive bladder cancer and this new technique gained acceptance in many centers. The issue of oncological safety of a urethra and anterior vaginal wall‐sparing cystectomy in selected patients has been addressed by several authors. The chapter will discuss the following items: (I) Technique of genital‐sparing radical cystectomy in female patients with muscle invasive transitional cell carcinoma of the bladder. (II) Definition and rationale of genital‐sparing radical cystectomy in female patients. (III) Rational and value of urethral preservation in genital‐sparing cystectomy in female patients with urothelial carcinoma. (IV) Previous reports about genital‐sparing cystectomy in patients with urothelial carcinoma. (V) Value of preservation of the internal genital organs in female patients undergoing radical cystectomy.",book:{id:"5516",slug:"bladder-cancer-management-of-nmi-and-muscle-invasive-cancer",title:"Bladder Cancer",fullTitle:"Bladder Cancer - Management of NMI and Muscle-Invasive Cancer"},signatures:"Hosni Khairy Salem",authors:[{id:"96052",title:"Prof.",name:"Hosni",middleName:"Khairy",surname:"Salem",slug:"hosni-salem",fullName:"Hosni Salem"}]},{id:"67209",title:"Robotic Surgery and Successful Set-Up: A Stepwise Approach",slug:"robotic-surgery-and-successful-set-up-a-stepwise-approach",totalDownloads:690,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"Robot purchase, implementation, and sustainability require a number of key challenges to overcome. We provide our experience of managing a potentially daunting task, summarizing the key steps to help deliver such an exciting project. 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",coverUrl:"https://cdn.intechopen.com/series/covers/3.jpg",latestPublicationDate:"August 14th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:9,editor:{id:"419588",title:"Ph.D.",name:"Sergio",middleName:"Alexandre",surname:"Gehrke",slug:"sergio-gehrke",fullName:"Sergio Gehrke",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038WgMKQA0/Profile_Picture_2022-06-02T11:44:20.jpg",biography:"Dr. Sergio Alexandre Gehrke is a doctorate holder in two fields. The first is a Ph.D. in Cellular and Molecular Biology from the Pontificia Catholic University, Porto Alegre, Brazil, in 2010 and the other is an International Ph.D. in Bioengineering from the Universidad Miguel Hernandez, Elche/Alicante, Spain, obtained in 2020. In 2018, he completed a postdoctoral fellowship in Materials Engineering in the NUCLEMAT of the Pontificia Catholic University, Porto Alegre, Brazil. He is currently the Director of the Postgraduate Program in Implantology of the Bioface/UCAM/PgO (Montevideo, Uruguay), Director of the Cathedra of Biotechnology of the Catholic University of Murcia (Murcia, Spain), an Extraordinary Full Professor of the Catholic University of Murcia (Murcia, Spain) as well as the Director of the private center of research Biotecnos – Technology and Science (Montevideo, Uruguay). Applied biomaterials, cellular and molecular biology, and dental implants are among his research interests. He has published several original papers in renowned journals. In addition, he is also a Collaborating Professor in several Postgraduate programs at different universities all over the world.",institutionString:null,institution:{name:"Universidad Católica San Antonio de Murcia",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:6,paginationItems:[{id:"22",title:"Applied Intelligence",coverUrl:"https://cdn.intechopen.com/series_topics/covers/22.jpg",isOpenForSubmission:!0,editor:{id:"27170",title:"Prof.",name:"Carlos",middleName:"M.",surname:"Travieso-Gonzalez",slug:"carlos-travieso-gonzalez",fullName:"Carlos Travieso-Gonzalez",profilePictureURL:"https://mts.intechopen.com/storage/users/27170/images/system/27170.jpeg",biography:"Carlos M. Travieso-González received his MSc degree in Telecommunication Engineering at Polytechnic University of Catalonia (UPC), Spain in 1997, and his Ph.D. degree in 2002 at the University of Las Palmas de Gran Canaria (ULPGC-Spain). He is a full professor of signal processing and pattern recognition and is head of the Signals and Communications Department at ULPGC, teaching from 2001 on subjects on signal processing and learning theory. His research lines are biometrics, biomedical signals and images, data mining, classification system, signal and image processing, machine learning, and environmental intelligence. He has researched in 52 international and Spanish research projects, some of them as head researcher. He is co-author of 4 books, co-editor of 27 proceedings books, guest editor for 8 JCR-ISI international journals, and up to 24 book chapters. He has over 450 papers published in international journals and conferences (81 of them indexed on JCR – ISI - Web of Science). He has published seven patents in the Spanish Patent and Trademark Office. He has been a supervisor on 8 Ph.D. theses (11 more are under supervision), and 130 master theses. He is the founder of The IEEE IWOBI conference series and the president of its Steering Committee, as well as the founder of both the InnoEducaTIC and APPIS conference series. He is an evaluator of project proposals for the European Union (H2020), Medical Research Council (MRC, UK), Spanish Government (ANECA, Spain), Research National Agency (ANR, France), DAAD (Germany), Argentinian Government, and the Colombian Institutions. He has been a reviewer in different indexed international journals (<70) and conferences (<250) since 2001. He has been a member of the IASTED Technical Committee on Image Processing from 2007 and a member of the IASTED Technical Committee on Artificial Intelligence and Expert Systems from 2011. \n\nHe has held the general chair position for the following: ACM-APPIS (2020, 2021), IEEE-IWOBI (2019, 2020 and 2020), A PPIS (2018, 2019), IEEE-IWOBI (2014, 2015, 2017, 2018), InnoEducaTIC (2014, 2017), IEEE-INES (2013), NoLISP (2011), JRBP (2012), and IEEE-ICCST (2005)\n\nHe is an associate editor of the Computational Intelligence and Neuroscience Journal (Hindawi – Q2 JCR-ISI). He was vice dean from 2004 to 2010 in the Higher Technical School of Telecommunication Engineers at ULPGC and the vice dean of Graduate and Postgraduate Studies from March 2013 to November 2017. He won the “Catedra Telefonica” Awards in Modality of Knowledge Transfer, 2017, 2018, and 2019 editions, and awards in Modality of COVID Research in 2020.\n\nPublic References:\nResearcher ID http://www.researcherid.com/rid/N-5967-2014\nORCID https://orcid.org/0000-0002-4621-2768 \nScopus Author ID https://www.scopus.com/authid/detail.uri?authorId=6602376272\nScholar Google https://scholar.google.es/citations?user=G1ks9nIAAAAJ&hl=en \nResearchGate https://www.researchgate.net/profile/Carlos_Travieso",institutionString:null,institution:{name:"University of Las Palmas de Gran Canaria",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"23",title:"Computational Neuroscience",coverUrl:"https://cdn.intechopen.com/series_topics/covers/23.jpg",isOpenForSubmission:!0,editor:{id:"14004",title:"Dr.",name:"Magnus",middleName:null,surname:"Johnsson",slug:"magnus-johnsson",fullName:"Magnus Johnsson",profilePictureURL:"https://mts.intechopen.com/storage/users/14004/images/system/14004.png",biography:"Dr Magnus Johnsson is a cross-disciplinary scientist, lecturer, scientific editor and AI/machine learning consultant from Sweden. \n\nHe is currently at Malmö University in Sweden, but also held positions at Lund University in Sweden and at Moscow Engineering Physics Institute. \nHe holds editorial positions at several international scientific journals and has served as a scientific editor for books and special journal issues. \nHis research interests are wide and include, but are not limited to, autonomous systems, computer modeling, artificial neural networks, artificial intelligence, cognitive neuroscience, cognitive robotics, cognitive architectures, cognitive aids and the philosophy of mind. \n\nDr. Johnsson has experience from working in the industry and he has a keen interest in the application of neural networks and artificial intelligence to fields like industry, finance, and medicine. \n\nWeb page: www.magnusjohnsson.se",institutionString:null,institution:{name:"Malmö University",institutionURL:null,country:{name:"Sweden"}}},editorTwo:null,editorThree:null},{id:"24",title:"Computer Vision",coverUrl:"https://cdn.intechopen.com/series_topics/covers/24.jpg",isOpenForSubmission:!0,editor:{id:"294154",title:"Prof.",name:"George",middleName:null,surname:"Papakostas",slug:"george-papakostas",fullName:"George Papakostas",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002hYaGbQAK/Profile_Picture_1624519712088",biography:"George A. Papakostas has received a diploma in Electrical and Computer Engineering in 1999 and the M.Sc. and Ph.D. degrees in Electrical and Computer Engineering in 2002 and 2007, respectively, from the Democritus University of Thrace (DUTH), Greece. Dr. Papakostas serves as a Tenured Full Professor at the Department of Computer Science, International Hellenic University, Greece. Dr. Papakostas has 10 years of experience in large-scale systems design as a senior software engineer and technical manager, and 20 years of research experience in the field of Artificial Intelligence. Currently, he is the Head of the “Visual Computing” division of HUman-MAchines INteraction Laboratory (HUMAIN-Lab) and the Director of the MPhil program “Advanced Technologies in Informatics and Computers” hosted by the Department of Computer Science, International Hellenic University. He has (co)authored more than 150 publications in indexed journals, international conferences and book chapters, 1 book (in Greek), 3 edited books, and 5 journal special issues. His publications have more than 2100 citations with h-index 27 (GoogleScholar). His research interests include computer/machine vision, machine learning, pattern recognition, computational intelligence. \nDr. Papakostas served as a reviewer in numerous journals, as a program\ncommittee member in international conferences and he is a member of the IAENG, MIR Labs, EUCogIII, INSTICC and the Technical Chamber of Greece (TEE).",institutionString:null,institution:{name:"International Hellenic University",institutionURL:null,country:{name:"Greece"}}},editorTwo:null,editorThree:null},{id:"25",title:"Evolutionary Computation",coverUrl:"https://cdn.intechopen.com/series_topics/covers/25.jpg",isOpenForSubmission:!0,editor:{id:"136112",title:"Dr.",name:"Sebastian",middleName:null,surname:"Ventura Soto",slug:"sebastian-ventura-soto",fullName:"Sebastian Ventura Soto",profilePictureURL:"https://mts.intechopen.com/storage/users/136112/images/system/136112.png",biography:"Sebastian Ventura is a Spanish researcher, a full professor with the Department of Computer Science and Numerical Analysis, University of Córdoba. Dr Ventura also holds the positions of Affiliated Professor at Virginia Commonwealth University (Richmond, USA) and Distinguished Adjunct Professor at King Abdulaziz University (Jeddah, Saudi Arabia). Additionally, he is deputy director of the Andalusian Research Institute in Data Science and Computational Intelligence (DaSCI) and heads the Knowledge Discovery and Intelligent Systems Research Laboratory. He has published more than ten books and over 300 articles in journals and scientific conferences. Currently, his work has received over 18,000 citations according to Google Scholar, including more than 2200 citations in 2020. In the last five years, he has published more than 60 papers in international journals indexed in the JCR (around 70% of them belonging to first quartile journals) and he has edited some Springer books “Supervised Descriptive Pattern Mining” (2018), “Multiple Instance Learning - Foundations and Algorithms” (2016), and “Pattern Mining with Evolutionary Algorithms” (2016). He has also been involved in more than 20 research projects supported by the Spanish and Andalusian governments and the European Union. He currently belongs to the editorial board of PeerJ Computer Science, Information Fusion and Engineering Applications of Artificial Intelligence journals, being also associate editor of Applied Computational Intelligence and Soft Computing and IEEE Transactions on Cybernetics. Finally, he is editor-in-chief of Progress in Artificial Intelligence. He is a Senior Member of the IEEE Computer, the IEEE Computational Intelligence, and the IEEE Systems, Man, and Cybernetics Societies, and the Association of Computing Machinery (ACM). Finally, his main research interests include data science, computational intelligence, and their applications.",institutionString:null,institution:{name:"University of Córdoba",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"26",title:"Machine Learning and Data Mining",coverUrl:"https://cdn.intechopen.com/series_topics/covers/26.jpg",isOpenForSubmission:!0,editor:{id:"24555",title:"Dr.",name:"Marco Antonio",middleName:null,surname:"Aceves Fernandez",slug:"marco-antonio-aceves-fernandez",fullName:"Marco Antonio Aceves Fernandez",profilePictureURL:"https://mts.intechopen.com/storage/users/24555/images/system/24555.jpg",biography:"Dr. Marco Antonio Aceves Fernandez obtained his B.Sc. (Eng.) in Telematics from the Universidad de Colima, Mexico. He obtained both his M.Sc. and Ph.D. from the University of Liverpool, England, in the field of Intelligent Systems. He is a full professor at the Universidad Autonoma de Queretaro, Mexico, and a member of the National System of Researchers (SNI) since 2009. Dr. Aceves Fernandez has published more than 80 research papers as well as a number of book chapters and congress papers. He has contributed in more than 20 funded research projects, both academic and industrial, in the area of artificial intelligence, ranging from environmental, biomedical, automotive, aviation, consumer, and robotics to other applications. He is also a honorary president at the National Association of Embedded Systems (AMESE), a senior member of the IEEE, and a board member of many institutions. His research interests include intelligent and embedded systems.",institutionString:"Universidad Autonoma de Queretaro",institution:{name:"Autonomous University of Queretaro",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null},{id:"27",title:"Multi-Agent Systems",coverUrl:"https://cdn.intechopen.com/series_topics/covers/27.jpg",isOpenForSubmission:!0,editor:{id:"148497",title:"Dr.",name:"Mehmet",middleName:"Emin",surname:"Aydin",slug:"mehmet-aydin",fullName:"Mehmet Aydin",profilePictureURL:"https://mts.intechopen.com/storage/users/148497/images/system/148497.jpg",biography:"Dr. Mehmet Emin Aydin is a Senior Lecturer with the Department of Computer Science and Creative Technology, the University of the West of England, Bristol, UK. His research interests include swarm intelligence, parallel and distributed metaheuristics, machine learning, intelligent agents and multi-agent systems, resource planning, scheduling and optimization, combinatorial optimization. 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He is the author of several scientific articles, book chapters, and books.",institutionString:"University of Hassan II Casablanca",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"7",totalChapterViews:"0",totalEditedBooks:"2",institution:{name:"University of Hassan II Casablanca",institutionURL:null,country:{name:"Morocco"}}},equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7060",title:"Gingival Disease",subtitle:"A Professional Approach for Treatment and Prevention",coverURL:"https://cdn.intechopen.com/books/images_new/7060.jpg",slug:"gingival-disease-a-professional-approach-for-treatment-and-prevention",publishedDate:"October 23rd 2019",editedByType:"Edited by",bookSignature:"Alaa Eddin Omar Al Ostwani",hash:"b81d39988cba3a3cf746c1616912cf41",volumeInSeries:4,fullTitle:"Gingival Disease - A Professional Approach for Treatment and Prevention",editors:[{id:"240870",title:"Ph.D.",name:"Alaa Eddin Omar",middleName:null,surname:"Al Ostwani",slug:"alaa-eddin-omar-al-ostwani",fullName:"Alaa Eddin Omar Al Ostwani",profilePictureURL:"https://mts.intechopen.com/storage/users/240870/images/system/240870.jpeg",institutionString:"International University for Science and Technology.",institution:{name:"Islamic University of Science and Technology",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7572",title:"Trauma in Dentistry",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7572.jpg",slug:"trauma-in-dentistry",publishedDate:"July 3rd 2019",editedByType:"Edited by",bookSignature:"Serdar Gözler",hash:"7cb94732cfb315f8d1e70ebf500eb8a9",volumeInSeries:3,fullTitle:"Trauma in Dentistry",editors:[{id:"204606",title:"Dr.",name:"Serdar",middleName:null,surname:"Gözler",slug:"serdar-gozler",fullName:"Serdar Gözler",profilePictureURL:"https://mts.intechopen.com/storage/users/204606/images/system/204606.jpeg",institutionString:"Istanbul Aydin University",institution:{name:"Istanbul Aydın University",institutionURL:null,country:{name:"Turkey"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7139",title:"Current Approaches in Orthodontics",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7139.jpg",slug:"current-approaches-in-orthodontics",publishedDate:"April 10th 2019",editedByType:"Edited by",bookSignature:"Belma Işık Aslan and Fatma Deniz Uzuner",hash:"2c77384eeb748cf05a898d65b9dcb48a",volumeInSeries:2,fullTitle:"Current Approaches in Orthodontics",editors:[{id:"42847",title:"Dr.",name:"Belma",middleName:null,surname:"Işik Aslan",slug:"belma-isik-aslan",fullName:"Belma Işik Aslan",profilePictureURL:"https://mts.intechopen.com/storage/users/42847/images/system/42847.jpg",institutionString:"Gazi University Dentistry Faculty Department of Orthodontics",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"6668",title:"Dental Caries",subtitle:"Diagnosis, Prevention and Management",coverURL:"https://cdn.intechopen.com/books/images_new/6668.jpg",slug:"dental-caries-diagnosis-prevention-and-management",publishedDate:"September 19th 2018",editedByType:"Edited by",bookSignature:"Zühre Akarslan",hash:"b0f7667770a391f772726c3013c1b9ba",volumeInSeries:1,fullTitle:"Dental Caries - Diagnosis, Prevention and Management",editors:[{id:"171887",title:"Prof.",name:"Zühre",middleName:null,surname:"Akarslan",slug:"zuhre-akarslan",fullName:"Zühre Akarslan",profilePictureURL:"https://mts.intechopen.com/storage/users/171887/images/system/171887.jpg",institutionString:"Gazi University",institution:{name:"Gazi University",institutionURL:null,country:{name:"Turkey"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Prosthodontics and Implant Dentistry",value:2,count:3},{group:"subseries",caption:"Oral Health",value:1,count:6}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:3},{group:"publicationYear",caption:"2020",value:2020,count:2},{group:"publicationYear",caption:"2019",value:2019,count:3},{group:"publicationYear",caption:"2018",value:2018,count:1}],authors:{paginationCount:229,paginationItems:[{id:"318170",title:"Dr.",name:"Aneesa",middleName:null,surname:"Moolla",slug:"aneesa-moolla",fullName:"Aneesa Moolla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/318170/images/system/318170.png",biography:"Dr. Aneesa Moolla has extensive experience in the diverse fields of health care having previously worked in dental private practice, at the Red Cross Flying Doctors association, and in healthcare corporate settings. She is now a lecturer at the University of Witwatersrand, South Africa, and a principal researcher at the Health Economics and Epidemiology Research Office (HE2RO), South Africa. Dr. Moolla holds a Ph.D. in Psychology with her research being focused on mental health and resilience. In her professional work capacity, her research has further expanded into the fields of early childhood development, mental health, the HIV and TB care cascades, as well as COVID. She is also a UNESCO-trained International Bioethics Facilitator.",institutionString:"University of the Witwatersrand",institution:{name:"University of the Witwatersrand",country:{name:"South Africa"}}},{id:"419588",title:"Ph.D.",name:"Sergio",middleName:"Alexandre",surname:"Gehrke",slug:"sergio-gehrke",fullName:"Sergio Gehrke",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038WgMKQA0/Profile_Picture_2022-06-02T11:44:20.jpg",biography:"Dr. Sergio Alexandre Gehrke is a doctorate holder in two fields. The first is a Ph.D. in Cellular and Molecular Biology from the Pontificia Catholic University, Porto Alegre, Brazil, in 2010 and the other is an International Ph.D. in Bioengineering from the Universidad Miguel Hernandez, Elche/Alicante, Spain, obtained in 2020. In 2018, he completed a postdoctoral fellowship in Materials Engineering in the NUCLEMAT of the Pontificia Catholic University, Porto Alegre, Brazil. He is currently the Director of the Postgraduate Program in Implantology of the Bioface/UCAM/PgO (Montevideo, Uruguay), Director of the Cathedra of Biotechnology of the Catholic University of Murcia (Murcia, Spain), an Extraordinary Full Professor of the Catholic University of Murcia (Murcia, Spain) as well as the Director of the private center of research Biotecnos – Technology and Science (Montevideo, Uruguay). Applied biomaterials, cellular and molecular biology, and dental implants are among his research interests. He has published several original papers in renowned journals. In addition, he is also a Collaborating Professor in several Postgraduate programs at different universities all over the world.",institutionString:null,institution:{name:"Universidad Católica San Antonio de Murcia",country:{name:"Spain"}}},{id:"342152",title:"Dr.",name:"Santo",middleName:null,surname:"Grace Umesh",slug:"santo-grace-umesh",fullName:"Santo Grace Umesh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/342152/images/16311_n.jpg",biography:null,institutionString:null,institution:{name:"SRM Dental College",country:{name:"India"}}},{id:"333647",title:"Dr.",name:"Shreya",middleName:null,surname:"Kishore",slug:"shreya-kishore",fullName:"Shreya Kishore",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333647/images/14701_n.jpg",biography:"Dr. Shreya Kishore completed her Bachelor in Dental Surgery in Chettinad Dental College and Research Institute, Chennai, and her Master of Dental Surgery (Orthodontics) in Saveetha Dental College, Chennai. She is also Invisalign certified. She’s working as a Senior Lecturer in the Department of Orthodontics, SRM Dental College since November 2019. She is actively involved in teaching orthodontics to the undergraduates and the postgraduates. Her clinical research topics include new orthodontic brackets, fixed appliances and TADs. She’s published 4 articles in well renowned indexed journals and has a published patency of her own. Her private practice is currently limited to orthodontics and works as a consultant in various clinics.",institutionString:null,institution:{name:"SRM Dental College",country:{name:"India"}}},{id:"323731",title:"Prof.",name:"Deepak M.",middleName:"Macchindra",surname:"Vikhe",slug:"deepak-m.-vikhe",fullName:"Deepak M. Vikhe",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/323731/images/13613_n.jpg",biography:"Dr Deepak M.Vikhe .\n\n\t\n\tDr Deepak M.Vikhe , completed his Masters & PhD in Prosthodontics from Rural Dental College, Loni securing third rank in the Pravara Institute of Medical Sciences Deemed University. He was awarded Dr.G.C.DAS Memorial Award for Research on Implants at 39th IPS conference Dubai (U A E).He has two patents under his name. He has received Dr.Saraswati medal award for best research for implant study in 2017.He has received Fully funded scholarship to Spain ,university of Santiago de Compostela. He has completed fellowship in Implantlogy from Noble Biocare. \nHe has attended various conferences and CDE programmes and has national publications to his credit. His field of interest is in Implant supported prosthesis. Presently he is working as a associate professor in the Dept of Prosthodontics, Rural Dental College, Loni and maintains a successful private practice specialising in Implantology at Rahata.\n\nEmail: drdeepak_mvikhe@yahoo.com..................",institutionString:null,institution:{name:"Pravara Institute of Medical Sciences",country:{name:"India"}}},{id:"204110",title:"Dr.",name:"Ahmed A.",middleName:null,surname:"Madfa",slug:"ahmed-a.-madfa",fullName:"Ahmed A. Madfa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204110/images/system/204110.jpg",biography:"Dr. Madfa is currently Associate Professor of Endodontics at Thamar University and a visiting lecturer at Sana'a University and University of Sciences and Technology. He has more than 6 years of experience in teaching. His research interests include root canal morphology, functionally graded concept, dental biomaterials, epidemiology and dental education, biomimetic restoration, finite element analysis and endodontic regeneration. Dr. Madfa has numerous international publications, full articles, two patents, a book and a book chapter. Furthermore, he won 14 international scientific awards. Furthermore, he is involved in many academic activities ranging from editorial board member, reviewer for many international journals and postgraduate students' supervisor. Besides, I deliver many courses and training workshops at various scientific events. Dr. Madfa also regularly attends international conferences and holds administrative positions (Deputy Dean of the Faculty for Students’ & Academic Affairs and Deputy Head of Research Unit).",institutionString:"Thamar University",institution:null},{id:"210472",title:"Dr.",name:"Nermin",middleName:"Mohammed Ahmed",surname:"Yussif",slug:"nermin-yussif",fullName:"Nermin Yussif",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/210472/images/system/210472.jpg",biography:"Dr. Nermin Mohammed Ahmed Yussif is working at the Faculty of dentistry, University for October university for modern sciences and arts (MSA). Her areas of expertise include: periodontology, dental laserology, oral implantology, periodontal plastic surgeries, oral mesotherapy, nutrition, dental pharmacology. She is an editor and reviewer in numerous international journals.",institutionString:"MSA University",institution:null},{id:"204606",title:"Dr.",name:"Serdar",middleName:null,surname:"Gözler",slug:"serdar-gozler",fullName:"Serdar Gözler",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204606/images/system/204606.jpeg",biography:"Dr. Serdar Gözler has completed his undergraduate studies at the Marmara University Faculty of Dentistry in 1978, followed by an assistantship in the Prosthesis Department of Dicle University Faculty of Dentistry. Starting his PhD work on non-resilient overdentures with Assoc. Prof. Hüsnü Yavuzyılmaz, he continued his studies with Prof. Dr. Gürbüz Öztürk of Istanbul University Faculty of Dentistry Department of Prosthodontics, this time on Gnatology. He attended training programs on occlusion, neurology, neurophysiology, EMG, radiology and biostatistics. In 1982, he presented his PhD thesis \\Gerber and Lauritzen Occlusion Analysis Techniques: Diagnosis Values,\\ at Istanbul University School of Dentistry, Department of Prosthodontics. As he was also working with Prof. Senih Çalıkkocaoğlu on The Physiology of Chewing at the same time, Gözler has written a chapter in Çalıkkocaoğlu\\'s book \\Complete Prostheses\\ entitled \\The Place of Neuromuscular Mechanism in Prosthetic Dentistry.\\ The book was published five times since by the Istanbul University Publications. Having presented in various conferences about occlusion analysis until 1998, Dr. Gözler has also decided to use the T-Scan II occlusion analysis method. Having been personally trained by Dr. Robert Kerstein on this method, Dr. Gözler has been lecturing on the T-Scan Occlusion Analysis Method in conferences both in Turkey and abroad. Dr. Gözler has various articles and presentations on Digital Occlusion Analysis methods. He is now Head of the TMD Clinic at Prosthodontic Department of Faculty of Dentistry , Istanbul Aydın University , Turkey.",institutionString:"Istanbul Aydin University",institution:{name:"Istanbul Aydın University",country:{name:"Turkey"}}},{id:"256417",title:"Associate Prof.",name:"Sanaz",middleName:null,surname:"Sadry",slug:"sanaz-sadry",fullName:"Sanaz Sadry",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/256417/images/8106_n.jpg",biography:null,institutionString:null,institution:{name:"Istanbul Aydın University",country:{name:"Turkey"}}},{id:"240870",title:"Ph.D.",name:"Alaa Eddin Omar",middleName:null,surname:"Al Ostwani",slug:"alaa-eddin-omar-al-ostwani",fullName:"Alaa Eddin Omar Al Ostwani",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/240870/images/system/240870.jpeg",biography:"Dr. Al Ostwani Alaa Eddin Omar received his Master in dentistry from Damascus University in 2010, and his Ph.D. in Pediatric Dentistry from Damascus University in 2014. Dr. Al Ostwani is an assistant professor and faculty member at IUST University since 2014. \nDuring his academic experience, he has received several awards including the scientific research award from the Union of Arab Universities, the Syrian gold medal and the international gold medal for invention and creativity. Dr. Al Ostwani is a Member of the International Association of Dental Traumatology and the Syrian Society for Research and Preventive Dentistry since 2017. He is also a Member of the Reviewer Board of International Journal of Dental Medicine (IJDM), and the Indian Journal of Conservative and Endodontics since 2016.",institutionString:"International University for Science and Technology.",institution:{name:"Islamic University of Science and Technology",country:{name:"India"}}},{id:"42847",title:"Dr.",name:"Belma",middleName:null,surname:"Işik Aslan",slug:"belma-isik-aslan",fullName:"Belma Işik Aslan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/42847/images/system/42847.jpg",biography:"Dr. Belma IşIk Aslan was born in 1976 in Ankara-TURKEY. After graduating from TED Ankara College in 1994, she attended to Gazi University, Faculty of Dentistry in Ankara. She completed her PhD in orthodontic education at Gazi University between 1999-2005. Dr. Işık Aslan stayed at the Providence Hospital Craniofacial Institude and Reconstructive Surgery in Michigan, USA for three months as an observer. She worked as a specialist doctor at Gazi University, Dentistry Faculty, Department of Orthodontics between 2005-2014. She was appointed as associate professor in January, 2014 and as professor in 2021. Dr. Işık Aslan still works as an instructor at the same faculty. She has published a total of 35 articles, 10 book chapters, 39 conference proceedings both internationally and nationally. Also she was the academic editor of the international book 'Current Advances in Orthodontics'. She is a member of the Turkish Orthodontic Society and Turkish Cleft Lip and Palate Society. She is married and has 2 children. Her knowledge of English is at an advanced level.",institutionString:"Gazi University Dentistry Faculty Department of Orthodontics",institution:null},{id:"202198",title:"Dr.",name:"Buket",middleName:null,surname:"Aybar",slug:"buket-aybar",fullName:"Buket Aybar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202198/images/6955_n.jpg",biography:"Buket Aybar, DDS, PhD, was born in 1971. She graduated from Istanbul University, Faculty of Dentistry, in 1992 and completed her PhD degree on Oral and Maxillofacial Surgery in Istanbul University in 1997.\r\nDr. Aybar is currently a full-time professor in Istanbul University, Faculty of Dentistry Department of Oral and Maxillofacial Surgery. She has teaching responsibilities in graduate and postgraduate programs. Her clinical practice includes mainly dentoalveolar surgery.\r\nHer topics of interest are biomaterials science and cell culture studies. She has many articles in international and national scientific journals and chapters in books; she also has participated in several scientific projects supported by Istanbul University Research fund.",institutionString:null,institution:{name:"Marmara University",country:{name:"Turkey"}}},{id:"178412",title:"Associate Prof.",name:"Guhan",middleName:null,surname:"Dergin",slug:"guhan-dergin",fullName:"Guhan Dergin",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178412/images/6954_n.jpg",biography:"Assoc. Prof. Dr. Gühan Dergin was born in 1973 in Izmit. He graduated from Marmara University Faculty of Dentistry in 1999. He completed his specialty of OMFS surgery in Marmara University Faculty of Dentistry and obtained his PhD degree in 2006. In 2005, he was invited as a visiting doctor in the Oral and Maxillofacial Surgery Department of the University of North Carolina, USA, where he went on a scholarship. Dr. Dergin still continues his academic career as an associate professor in Marmara University Faculty of Dentistry. He has many articles in international and national scientific journals and chapters in books.",institutionString:null,institution:{name:"Marmara University",country:{name:"Turkey"}}},{id:"178414",title:"Prof.",name:"Yusuf",middleName:null,surname:"Emes",slug:"yusuf-emes",fullName:"Yusuf Emes",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178414/images/6953_n.jpg",biography:"Born in Istanbul in 1974, Dr. Emes graduated from Istanbul University Faculty of Dentistry in 1997 and completed his PhD degree in Istanbul University faculty of Dentistry Department of Oral and Maxillofacial Surgery in 2005. He has papers published in international and national scientific journals, including research articles on implantology, oroantral fistulas, odontogenic cysts, and temporomandibular disorders. Dr. Emes is currently working as a full-time academic staff in Istanbul University faculty of Dentistry Department of Oral and Maxillofacial Surgery.",institutionString:null,institution:{name:"Istanbul University",country:{name:"Turkey"}}},{id:"192229",title:"Ph.D.",name:"Ana Luiza",middleName:null,surname:"De Carvalho Felippini",slug:"ana-luiza-de-carvalho-felippini",fullName:"Ana Luiza De Carvalho Felippini",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192229/images/system/192229.jpg",biography:null,institutionString:"University of São Paulo",institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"256851",title:"Prof.",name:"Ayşe",middleName:null,surname:"Gülşen",slug:"ayse-gulsen",fullName:"Ayşe Gülşen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/256851/images/9696_n.jpg",biography:"Dr. Ayşe Gülşen graduated in 1990 from Faculty of Dentistry, University of Ankara and did a postgraduate program at University of Gazi. \nShe worked as an observer and research assistant in Craniofacial Surgery Departments in New York, Providence Hospital in Michigan and Chang Gung Memorial Hospital in Taiwan. \nShe works as Craniofacial Orthodontist in Department of Aesthetic, Plastic and Reconstructive Surgery, Faculty of Medicine, University of Gazi, Ankara Turkey since 2004.",institutionString:"Orthodontist, Assoc Prof in the Department of Aesthetic, Plastic and Reconstructive Surgery, Faculty of Medicine, University of Gazi",institution:null},{id:"255366",title:"Prof.",name:"Tosun",middleName:null,surname:"Tosun",slug:"tosun-tosun",fullName:"Tosun Tosun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255366/images/7347_n.jpg",biography:"Graduated at the Faculty of Dentistry, University of Istanbul, Turkey in 1989;\nVisitor Assistant at the University of Padua, Italy and Branemark Osseointegration Center of Treviso, Italy between 1993-94;\nPhD thesis on oral implantology in University of Istanbul and was awarded the academic title “Dr.med.dent.”, 1997;\nHe was awarded the academic title “Doç.Dr.” (Associated Professor) in 2003;\nProficiency in Botulinum Toxin Applications, Reading-UK in 2009;\nMastership, RWTH Certificate in Laser Therapy in Dentistry, AALZ-Aachen University, Germany 2009-11;\nMaster of Science (MSc) in Laser Dentistry, University of Genoa, Italy 2013-14.\n\nDr.Tosun worked as Research Assistant in the Department of Oral Implantology, Faculty of Dentistry, University of Istanbul between 1990-2002. \nHe worked part-time as Consultant surgeon in Harvard Medical International Hospitals and John Hopkins Medicine, Istanbul between years 2007-09.\u2028He was contract Professor in the Department of Surgical and Diagnostic Sciences (DI.S.C.), Medical School, University of Genova, Italy between years 2011-16. \nSince 2015 he is visiting Professor at Medical School, University of Plovdiv, Bulgaria. \nCurrently he is Associated Prof.Dr. at the Dental School, Oral Surgery Dept., Istanbul Aydin University and since 2003 he works in his own private clinic in Istanbul, Turkey.\u2028\nDr.Tosun is reviewer in journal ‘Laser in Medical Sciences’, reviewer in journal ‘Folia Medica\\', a Fellow of the International Team for Implantology, Clinical Lecturer of DGZI German Association of Oral Implantology, Expert Lecturer of Laser&Health Academy, Country Representative of World Federation for Laser Dentistry, member of European Federation of Periodontology, member of Academy of Laser Dentistry. Dr.Tosun presents papers in international and national congresses and has scientific publications in international and national journals. He speaks english, spanish, italian and french.",institutionString:null,institution:{name:"Istanbul Aydın University",country:{name:"Turkey"}}},{id:"260116",title:"Dr.",name:"Mehmet",middleName:null,surname:"Yaltirik",slug:"mehmet-yaltirik",fullName:"Mehmet Yaltirik",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/260116/images/7413_n.jpg",biography:"Birth Date 25.09.1965\r\nBirth Place Adana- Turkey\r\nSex Male\r\nMarrial Status Bachelor\r\nDriving License Acquired\r\nMother Tongue Turkish\r\n\r\nAddress:\r\nWork:University of Istanbul,Faculty of Dentistry, Department of Oral Surgery and Oral Medicine 34093 Capa,Istanbul- TURKIYE",institutionString:null,institution:{name:"Istanbul University",country:{name:"Turkey"}}},{id:"171887",title:"Prof.",name:"Zühre",middleName:null,surname:"Akarslan",slug:"zuhre-akarslan",fullName:"Zühre Akarslan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/171887/images/system/171887.jpg",biography:"Zühre Akarslan was born in 1977 in Cyprus. She graduated from Gazi University Faculty of Dentistry, Ankara, Turkey in 2000. \r\nLater she received her Ph.D. degree from the Oral Diagnosis and Radiology Department; which was recently renamed as Oral and Dentomaxillofacial Radiology, from the same university. \r\nShe is working as a full-time Associate Professor and is a lecturer and an academic researcher. \r\nHer expertise areas are dental caries, cancer, dental fear and anxiety, gag reflex in dentistry, oral medicine, and dentomaxillofacial radiology.",institutionString:"Gazi University",institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"272237",title:"Dr.",name:"Pinar",middleName:"Kiymet",surname:"Karataban",slug:"pinar-karataban",fullName:"Pinar Karataban",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/272237/images/8911_n.png",biography:"Assist.Prof.Dr.Pınar Kıymet Karataban, DDS PhD \n\nDr.Pınar Kıymet Karataban was born in Istanbul in 1975. After her graduation from Marmara University Faculty of Dentistry in 1998 she started her PhD in Paediatric Dentistry focused on children with special needs; mainly children with Cerebral Palsy. She finished her pHD thesis entitled \\'Investigation of occlusion via cast analysis and evaluation of dental caries prevalance, periodontal status and muscle dysfunctions in children with cerebral palsy” in 2008. She got her Assist. Proffessor degree in Istanbul Aydın University Paediatric Dentistry Department in 2015-2018. ın 2019 she started her new career in Bahcesehir University, Istanbul as Head of Department of Pediatric Dentistry. In 2020 she was accepted to BAU International University, Batumi as Professor of Pediatric Dentistry. She’s a lecturer in the same university meanwhile working part-time in private practice in Ege Dental Studio (https://www.egedisklinigi.com/) a multidisciplinary dental clinic in Istanbul. Her main interests are paleodontology, ancient and contemporary dentistry, oral microbiology, cerebral palsy and special care dentistry. She has national and international publications, scientific reports and is a member of IAPO (International Association for Paleodontology), IADH (International Association of Disability and Oral Health) and EAPD (European Association of Pediatric Dentistry).",institutionString:null,institution:null},{id:"172009",title:"Dr.",name:"Fatma Deniz",middleName:null,surname:"Uzuner",slug:"fatma-deniz-uzuner",fullName:"Fatma Deniz Uzuner",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/172009/images/7122_n.jpg",biography:"Dr. Deniz Uzuner was born in 1969 in Kocaeli-TURKEY. After graduating from TED Ankara College in 1986, she attended the Hacettepe University, Faculty of Dentistry in Ankara. \nIn 1993 she attended the Gazi University, Faculty of Dentistry, Department of Orthodontics for her PhD education. After finishing the PhD education, she worked as orthodontist in Ankara Dental Hospital under the Turkish Government, Ministry of Health and in a special Orthodontic Clinic till 2011. Between 2011 and 2016, Dr. Deniz Uzuner worked as a specialist in the Department of Orthodontics, Faculty of Dentistry, Gazi University in Ankara/Turkey. In 2016, she was appointed associate professor. Dr. Deniz Uzuner has authored 23 Journal Papers, 3 Book Chapters and has had 39 oral/poster presentations. She is a member of the Turkish Orthodontic Society. 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This series is intended for doctors, engineers, and scientists involved in biomedical engineering or those wanting to start working in this field.",coverUrl:"https://cdn.intechopen.com/series/covers/7.jpg",latestPublicationDate:"August 3rd, 2022",hasOnlineFirst:!0,numberOfOpenTopics:3,numberOfPublishedChapters:107,numberOfPublishedBooks:12,editor:{id:"50150",title:"Prof.",name:"Robert",middleName:null,surname:"Koprowski",fullName:"Robert Koprowski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYTYNQA4/Profile_Picture_1630478535317",biography:"Robert Koprowski, MD (1997), PhD (2003), Habilitation (2015), is an employee of the University of Silesia, Poland, Institute of Computer Science, Department of Biomedical Computer Systems. For 20 years, he has studied the analysis and processing of biomedical images, emphasizing the full automation of measurement for a large inter-individual variability of patients. Dr. Koprowski has authored more than a hundred research papers with dozens in impact factor (IF) journals and has authored or co-authored six books. Additionally, he is the author of several national and international patents in the field of biomedical devices and imaging. Since 2011, he has been a reviewer of grants and projects (including EU projects) in biomedical engineering.",institutionString:null,institution:{name:"University of Silesia",institutionURL:null,country:{name:"Poland"}}},subseries:[{id:"7",title:"Bioinformatics and Medical Informatics",keywords:"Biomedical Data, Drug Discovery, Clinical Diagnostics, Decoding Human Genome, AI in Personalized Medicine, Disease-prevention Strategies, Big Data Analysis in Medicine",scope:"Bioinformatics aims to help understand the functioning of the mechanisms of living organisms through the construction and use of quantitative tools. The applications of this research cover many related fields, such as biotechnology and medicine, where, for example, Bioinformatics contributes to faster drug design, DNA analysis in forensics, and DNA sequence analysis in the field of personalized medicine. Personalized medicine is a type of medical care in which treatment is customized individually for each patient. Personalized medicine enables more effective therapy, reduces the costs of therapy and clinical trials, and also minimizes the risk of side effects. Nevertheless, advances in personalized medicine would not have been possible without bioinformatics, which can analyze the human genome and other vast amounts of biomedical data, especially in genetics. The rapid growth of information technology enabled the development of new tools to decode human genomes, large-scale studies of genetic variations and medical informatics. The considerable development of technology, including the computing power of computers, is also conducive to the development of bioinformatics, including personalized medicine. In an era of rapidly growing data volumes and ever lower costs of generating, storing and computing data, personalized medicine holds great promises. Modern computational methods used as bioinformatics tools can integrate multi-scale, multi-modal and longitudinal patient data to create even more effective and safer therapy and disease prevention methods. Main aspects of the topic are: Applying bioinformatics in drug discovery and development; Bioinformatics in clinical diagnostics (genetic variants that act as markers for a condition or a disease); Blockchain and Artificial Intelligence/Machine Learning in personalized medicine; Customize disease-prevention strategies in personalized medicine; Big data analysis in personalized medicine; Translating stratification algorithms into clinical practice of personalized medicine.",annualVolume:11403,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/7.jpg",editor:{id:"351533",title:"Dr.",name:"Slawomir",middleName:null,surname:"Wilczynski",fullName:"Slawomir Wilczynski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035U1loQAC/Profile_Picture_1630074514792",institutionString:null,institution:{name:"Medical University of Silesia",institutionURL:null,country:{name:"Poland"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"5886",title:"Dr.",name:"Alexandros",middleName:"T.",surname:"Tzallas",fullName:"Alexandros Tzallas",profilePictureURL:"https://mts.intechopen.com/storage/users/5886/images/system/5886.png",institutionString:"University of Ioannina, Greece & Imperial College London",institution:{name:"University of Ioannina",institutionURL:null,country:{name:"Greece"}}},{id:"257388",title:"Distinguished Prof.",name:"Lulu",middleName:null,surname:"Wang",fullName:"Lulu Wang",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRX6kQAG/Profile_Picture_1630329584194",institutionString:"Shenzhen Technology University",institution:{name:"Shenzhen Technology University",institutionURL:null,country:{name:"China"}}},{id:"225387",title:"Prof.",name:"Reda R.",middleName:"R.",surname:"Gharieb",fullName:"Reda R. Gharieb",profilePictureURL:"https://mts.intechopen.com/storage/users/225387/images/system/225387.jpg",institutionString:"Assiut University",institution:{name:"Assiut University",institutionURL:null,country:{name:"Egypt"}}}]},{id:"8",title:"Bioinspired Technology and Biomechanics",keywords:"Bioinspired Systems, Biomechanics, Assistive Technology, Rehabilitation",scope:'Bioinspired technologies take advantage of understanding the actual biological system to provide solutions to problems in several areas. Recently, bioinspired systems have been successfully employing biomechanics to develop and improve assistive technology and rehabilitation devices. The research topic "Bioinspired Technology and Biomechanics" welcomes studies reporting recent advances in bioinspired technologies that contribute to individuals\' health, inclusion, and rehabilitation. Possible contributions can address (but are not limited to) the following research topics: Bioinspired design and control of exoskeletons, orthoses, and prostheses; Experimental evaluation of the effect of assistive devices (e.g., influence on gait, balance, and neuromuscular system); Bioinspired technologies for rehabilitation, including clinical studies reporting evaluations; Application of neuromuscular and biomechanical models to the development of bioinspired technology.',annualVolume:11404,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/8.jpg",editor:{id:"144937",title:"Prof.",name:"Adriano",middleName:"De Oliveira",surname:"Andrade",fullName:"Adriano Andrade",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRC8QQAW/Profile_Picture_1625219101815",institutionString:null,institution:{name:"Federal University of Uberlândia",institutionURL:null,country:{name:"Brazil"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"49517",title:"Prof.",name:"Hitoshi",middleName:null,surname:"Tsunashima",fullName:"Hitoshi Tsunashima",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYTP4QAO/Profile_Picture_1625819726528",institutionString:null,institution:{name:"Nihon University",institutionURL:null,country:{name:"Japan"}}},{id:"425354",title:"Dr.",name:"Marcus",middleName:"Fraga",surname:"Vieira",fullName:"Marcus Vieira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003BJSgIQAX/Profile_Picture_1627904687309",institutionString:null,institution:{name:"Universidade Federal de Goiás",institutionURL:null,country:{name:"Brazil"}}},{id:"196746",title:"Dr.",name:"Ramana",middleName:null,surname:"Vinjamuri",fullName:"Ramana Vinjamuri",profilePictureURL:"https://mts.intechopen.com/storage/users/196746/images/system/196746.jpeg",institutionString:"University of Maryland, Baltimore County",institution:{name:"University of Maryland, Baltimore County",institutionURL:null,country:{name:"United States of America"}}}]},{id:"9",title:"Biotechnology - Biosensors, Biomaterials and Tissue Engineering",keywords:"Biotechnology, Biosensors, Biomaterials, Tissue Engineering",scope:"The Biotechnology - Biosensors, Biomaterials and Tissue Engineering topic within the Biomedical Engineering Series aims to rapidly publish contributions on all aspects of biotechnology, biosensors, biomaterial and tissue engineering. We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics can include but are not limited to: Biotechnology such as biotechnological products and process engineering; Biotechnologically relevant enzymes and proteins; Bioenergy and biofuels; Applied genetics and molecular biotechnology; Genomics, transcriptomics, proteomics; Applied microbial and cell physiology; Environmental biotechnology; Methods and protocols. Moreover, topics in biosensor technology, like sensors that incorporate enzymes, antibodies, nucleic acids, whole cells, tissues and organelles, and other biological or biologically inspired components will be considered, and topics exploring transducers, including those based on electrochemical and optical piezoelectric, thermal, magnetic, and micromechanical elements. Chapters exploring biomaterial approaches such as polymer synthesis and characterization, drug and gene vector design, biocompatibility, immunology and toxicology, and self-assembly at the nanoscale, are welcome. Finally, the tissue engineering subcategory will support topics such as the fundamentals of stem cells and progenitor cells and their proliferation, differentiation, bioreactors for three-dimensional culture and studies of phenotypic changes, stem and progenitor cells, both short and long term, ex vivo and in vivo implantation both in preclinical models and also in clinical trials.",annualVolume:11405,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/9.jpg",editor:{id:"126286",title:"Dr.",name:"Luis",middleName:"Jesús",surname:"Villarreal-Gómez",fullName:"Luis Villarreal-Gómez",profilePictureURL:"https://mts.intechopen.com/storage/users/126286/images/system/126286.jpg",institutionString:null,institution:{name:"Autonomous University of Baja California",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"35539",title:"Dr.",name:"Cecilia",middleName:null,surname:"Cristea",fullName:"Cecilia Cristea",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYQ65QAG/Profile_Picture_1621007741527",institutionString:null,institution:{name:"Iuliu Hațieganu University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"40735",title:"Dr.",name:"Gil",middleName:"Alberto Batista",surname:"Gonçalves",fullName:"Gil Gonçalves",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYRLGQA4/Profile_Picture_1628492612759",institutionString:null,institution:{name:"University of Aveiro",institutionURL:null,country:{name:"Portugal"}}},{id:"211725",title:"Associate Prof.",name:"Johann F.",middleName:null,surname:"Osma",fullName:"Johann F. 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