Open access peer-reviewed Edited Volume

The Mechanisms of DNA Replication

Edited by David Stuart

University of Alberta, Canada

DNA replication is a fundamental part of the life cycle of all organisms. Not surprisingly many aspects of this process display profound conservation across organisms in all domains of life. The chapters in this volume outline and review the current state of knowledge on several key aspects of the DNA replication process. This is a critical process in both normal growth and development and in relation to a broad variety of pathological conditions including cancer. The reader will be provided with new insights into the initiation, regulation, and progression of DNA replication as well as a collection of thought provoking questions and summaries to direct future investigations.

Read more >Order hardcopy
IntechOpen
The Mechanisms of DNA ReplicationEdited by David Stuart

Published: February 20th 2013

DOI: 10.5772/3433

ISBN: 978-953-51-0991-4

Copyright year: 2013

Books open for chapter submissions

28037 Total Chapter Downloads

9 Crossref Citations

12 Web of Science Citations

25 Dimensions Citations

chaptersDownloads

Open access peer-reviewed

1. Pulling the Trigger to Fire Origins of DNA Replication

By David Stuart

1285

Open access peer-reviewed

2. Replicative Helicases as the Central Organizing Motor Proteins in the Molecular Machines of the Elongating Eukaryotic Replication Fork

By John C. Fisk, Michaelle D. Chojnacki and Thomas Melendy

1076

Open access peer-reviewed

3. The MCM and RecQ Helicase Families: Ancient Roles in DNA Replication and Genomic Stability Lead to Distinct Roles in Human Disease

By Dianne C. Daniel*, Ayuna V. Dagdanova and Edward M. Johnson

1383

Open access peer-reviewed

4. DNA Replication in Archaea, the Third Domain of Life

By Yoshizumi Ishino and Sonoko Ishino

2002

Open access peer-reviewed

5. Proposal for a Minimal DNA Auto-Replicative System

By Agustino Martinez-Antonio, Laura Espindola-Serna and Cesar Quiñones-Valles

1329

Open access peer-reviewed

6. Extending the Interaction Repertoire of FHA and BRCT Domains

By Lindsay A. Matthews and Alba Guarne

1017

Open access peer-reviewed

7. Intrinsically Disordered Proteins in Replication Process

By Apolonija Bedina Zavec

1168

Open access peer-reviewed

8. Preserving the Replication Fork in Response to Nucleotide Starvation: Evading the Replication Fork Collapse Point

By Sarah A. Sabatinos and Susan L. Forsburg

1869

Open access peer-reviewed

9. The Role of WRN Helicase/Exonuclease in DNA Replication

By Lynne S. Cox and Penelope A. Mason

1419

Open access peer-reviewed

10. Replicational Mutation Gradients, Dipole Moments, Nearest Neighbour Effects and DNA Polymerase Gamma Fidelity in Human Mitochondrial Genomes

By Hervé Seligmann

885

Open access peer-reviewed

11. The Plant and Protist Organellar DNA Replication Enzyme POP Showing Up in Place of DNA Polymerase Gamma May Be a Suitable Antiprotozoal Drug Target

By Takashi Moriyama and Naoki Sato

1400

Open access peer-reviewed

12. Roles of Methylation and Sequestration in the Mechanisms of DNA Replication in some Members of the Enterobacteriaceae Family

By Amine Aloui, Alya El May, Saloua Kouass Sahbani and Ahmed Landoulsi

1500

Open access peer-reviewed

13. The Mechanisms of Epigenetic Modifications During DNA Replication

By Takeo Kubota, Kunio Miyake and Takae Hirasawa

2150

Open access peer-reviewed

14. Chromatin Damage Patterns Shift According to Eu/ Heterochromatin Replication

By María Vittoria Di Tomaso, Pablo Liddle, Laura Lafon-Hughes, Ana Laura Reyes-Ábalos and Gustavo Folle

2624

Open access peer-reviewed

15. A Histone Cycle

By Douglas Maya, Macarena Morillo-Huesca, Lidia Delgado Ramos, Sebastián Chávez and Mari-Cruz Muñoz-Centeno

2026

Open access peer-reviewed

16. Replicating – DNA in the Refractory Chromatin Environment

By Angélique Galvani and Christophe Thiriet

1022

Open access peer-reviewed

17. Telomeres: Their Structure and Maintenance

By Radmila Capkova Frydrychova and James M. Mason

1987

Open access peer-reviewed

18. Telomere Shortening Mechanisms

By Andrey Grach

1895

Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

Order a hardcopy of the Edited Volume

Free shipping with DHL Express

Hardcover (ex. VAT)£170

Order now

Residents of European Union countries need to add a Book Value-Added Tax of 5%. Institutions and companies, registered as VAT taxable entities in their own EU member state, will not pay VAT by providing IntechOpen with their VAT registration number. This is made possible by the EU reverse charge method.

Special discount for IntechOpen contributors

All IntechOpen contributors are offered special discounts starting at 40% OFF available through your personal dashboard

Login and purchase