Open access peer-reviewed Edited Volume

The Mechanisms of DNA Replication

Edited by David Stuart

University of Alberta, Canada

DNA replication is a fundamental part of the life cycle of all organisms. Not surprisingly many aspects of this process display profound conservation across organisms in all domains of life. The chapters in this volume outline and review the current state of knowledge on several key aspects of the DNA replication process. This is a critical process in both normal growth and development and in relation to a broad variety of pathological conditions including cancer. The reader will be provided with new insights into the initiation, regulation, and progression of DNA replication as well as a collection of thought provoking questions and summaries to direct future investigations.

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The Mechanisms of DNA ReplicationEdited by David Stuart

Published: February 20th 2013

DOI: 10.5772/3433

ISBN: 978-953-51-0991-4

eBook (PDF) ISBN: 978-953-51-5357-3

Copyright year: 2013

Books open for chapter submissions

35731 Total Chapter Downloads

16 Crossref Citations

27 Web of Science Citations

42 Dimensions Citations


Open access peer-reviewed

1. Pulling the Trigger to Fire Origins of DNA Replication

By David Stuart


Open access peer-reviewed

2. Replicative Helicases as the Central Organizing Motor Proteins in the Molecular Machines of the Elongating Eukaryotic Replication Fork

By John C. Fisk, Michaelle D. Chojnacki and Thomas Melendy


Open access peer-reviewed

3. The MCM and RecQ Helicase Families: Ancient Roles in DNA Replication and Genomic Stability Lead to Distinct Roles in Human Disease

By Dianne C. Daniel*, Ayuna V. Dagdanova and Edward M. Johnson


Open access peer-reviewed

4. DNA Replication in Archaea, the Third Domain of Life

By Yoshizumi Ishino and Sonoko Ishino


Open access peer-reviewed

5. Proposal for a Minimal DNA Auto-Replicative System

By Agustino Martinez-Antonio, Laura Espindola-Serna and Cesar Quiñones-Valles


Open access peer-reviewed

6. Extending the Interaction Repertoire of FHA and BRCT Domains

By Lindsay A. Matthews and Alba Guarne


Open access peer-reviewed

7. Intrinsically Disordered Proteins in Replication Process

By Apolonija Bedina Zavec


Open access peer-reviewed

8. Preserving the Replication Fork in Response to Nucleotide Starvation: Evading the Replication Fork Collapse Point

By Sarah A. Sabatinos and Susan L. Forsburg


Open access peer-reviewed

9. The Role of WRN Helicase/Exonuclease in DNA Replication

By Lynne S. Cox and Penelope A. Mason


Open access peer-reviewed

10. Replicational Mutation Gradients, Dipole Moments, Nearest Neighbour Effects and DNA Polymerase Gamma Fidelity in Human Mitochondrial Genomes

By Hervé Seligmann


Open access peer-reviewed

11. The Plant and Protist Organellar DNA Replication Enzyme POP Showing Up in Place of DNA Polymerase Gamma May Be a Suitable Antiprotozoal Drug Target

By Takashi Moriyama and Naoki Sato


Open access peer-reviewed

12. Roles of Methylation and Sequestration in the Mechanisms of DNA Replication in some Members of the Enterobacteriaceae Family

By Amine Aloui, Alya El May, Saloua Kouass Sahbani and Ahmed Landoulsi


Open access peer-reviewed

13. The Mechanisms of Epigenetic Modifications During DNA Replication

By Takeo Kubota, Kunio Miyake and Takae Hirasawa


Open access peer-reviewed

14. Chromatin Damage Patterns Shift According to Eu/ Heterochromatin Replication

By María Vittoria Di Tomaso, Pablo Liddle, Laura Lafon-Hughes, Ana Laura Reyes-Ábalos and Gustavo Folle


Open access peer-reviewed

15. A Histone Cycle

By Douglas Maya, Macarena Morillo-Huesca, Lidia Delgado Ramos, Sebastián Chávez and Mari-Cruz Muñoz-Centeno


Open access peer-reviewed

16. Replicating – DNA in the Refractory Chromatin Environment

By Angélique Galvani and Christophe Thiriet


Open access peer-reviewed

17. Telomeres: Their Structure and Maintenance

By Radmila Capkova Frydrychova and James M. Mason


Open access peer-reviewed

18. Telomere Shortening Mechanisms

By Andrey Grach


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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