\\n\\n
Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\\n\\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\\n"}]',published:!0,mainMedia:null},components:[{type:"htmlEditorComponent",content:'IntechOpen is proud to announce that 191 of our authors have made the Clarivate™ Highly Cited Researchers List for 2020, ranking them among the top 1% most-cited.
\n\nThroughout the years, the list has named a total of 261 IntechOpen authors as Highly Cited. Of those researchers, 69 have been featured on the list multiple times.
\n\n\n\nReleased this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\n\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\n'}],latestNews:[{slug:"intechopen-signs-new-contract-with-cepiec-china-for-distribution-of-open-access-books-20210319",title:"IntechOpen Signs New Contract with CEPIEC, China for Distribution of Open Access Books"},{slug:"150-million-downloads-and-counting-20210316",title:"150 Million Downloads and Counting"},{slug:"intechopen-secures-indefinite-content-preservation-with-clockss-20210309",title:"IntechOpen Secures Indefinite Content Preservation with CLOCKSS"},{slug:"intechopen-expands-to-all-global-amazon-channels-with-full-catalog-of-books-20210308",title:"IntechOpen Expands to All Global Amazon Channels with Full Catalog of Books"},{slug:"stanford-university-identifies-top-2-scientists-over-1-000-are-intechopen-authors-and-editors-20210122",title:"Stanford University Identifies Top 2% Scientists, Over 1,000 are IntechOpen Authors and Editors"},{slug:"intechopen-authors-included-in-the-highly-cited-researchers-list-for-2020-20210121",title:"IntechOpen Authors Included in the Highly Cited Researchers List for 2020"},{slug:"intechopen-maintains-position-as-the-world-s-largest-oa-book-publisher-20201218",title:"IntechOpen Maintains Position as the World’s Largest OA Book Publisher"},{slug:"all-intechopen-books-available-on-perlego-20201215",title:"All IntechOpen Books Available on Perlego"}]},book:{item:{type:"book",id:"5606",leadTitle:null,fullTitle:"Citrus Pathology",title:"Citrus Pathology",subtitle:null,reviewType:"peer-reviewed",abstract:"This book is an attempt to compile different aspects of citrus pathology to provide an overall knowledge to those who are interested in it, so that they may identify the bottlenecks to improve it further. The book chapters detail about citrus diseases, metabolic changes in citrus plants against various stresses, quorum sensing and its role in symptom development, preharvest and postharvest disease management, and application of citrus and its compounds. The goal of this book is to provide the most up-to-date review on information available on pathological aspects of citrus. 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These stresses not only play a major role in determining the crop yield and productivity but they also contribute to the differential distribution of plant species across different parts of the earth [4]. About 90% of the arable lands around the globe are susceptible to one or more of the above stresses causing up to 70% annual yield loss of major food crops [5]. The changing climate is further aggravating the impact of abiotic stress factors on the overall growth and development of various crops [6]. It is believed that exposure to salt stress in irrigated lands has been increased by 37% during the last 20 years [7]. Moreover, the occurrence of drought is increased due to alteration in the evapotranspiration and pattern of precipitation caused by global warming [8]. As per a recent meta-analysis study, a further increase of 2.0 to 4.9°C in the average earth temperature by 2100 is speculated which will further impose a huge challenge for sustainable agriculture in the future [9].
Plants respond to different environmental constraints through complex intricate mechanisms [1]. The ability of plants to adjust to different environmental conditions is directly or indirectly related to two major plant strategies - plant stress avoidance and plant stress tolerance. Plant’s stress avoidance is a physiologically non- active phase like mature seeds, while stress tolerance is an active reversible adjustment which is generally referred to as acclimation [10]. Acclimation to stress is particularly mediated through profound changes at the level of gene expression which results in changes or modifications in the composition of plant transcriptome, proteome as well as metabolome [11]. During the last few decades, researchers have focused on recognizing and elucidating the different components and molecular partners underlying abiotic stress responses in plants [12]. Several attempts have been made to produce crops/species with improved abiotic stress adaptive traits including drought and salinity. However, one of the massive challenges in modern sustainable agriculture is the development of abiotic stress-resilient crops with new and desired agronomical traits using different approaches. For this purpose, understanding the mechanisms by which plants perceive stress signals and further transmit them to cellular machinery for activating adaptive responses is of huge importance [13, 14, 15, 16]. In this context, marrying the various physiological, biochemical, and gene regulatory network knowledge is essential that will aid up in the development of stress-tolerant high-yielding food crop cultivars [17, 18]. Therefore, a holistic understanding of the different responses associated with abiotic stress adaptation by taking advantage of various available high throughput tools like proteomics, metabolomics, and transcriptomics is critical. Hence, the present chapter deals with the various responses associated with abiotic stress stimuli in plants and the current status, and future prospects of different approaches used to date for developing stress-resilient crops.
Plants face several types of variations in their physical environment that hampers their growth and development. They respond to these oscillating environmental conditions through a series of external and internal changes [19, 20]. These stress-specific responses are associated with an array of molecular players that modulates the morphology, anatomy, and physiology of plants [12, 13].
Plant cells can sense changing environmental signals leading to significant changes in their physiology, metabolism, and gene expression [12, 13]. The stress stimuli are first perceived at the level of cellular membranes that initiates a cascade of events to transmit the signal to various organelles thus activating the appropriate molecular network [21]. In plants, the primary cell wall is composed of cellulose fibrils connected by hemicellulose tethers embedded in a pectin gel providing mechanical strength for load-bearing. It also contains several structural proteins, phenolics, and calcium [22]. These components are often modified when plants are exposed to abiotic stresses. The overall architecture of the cell wall is affected by exposure to abiotic stress depending upon the species, the stress intensity, plant phenotype, plant genotype as well as the age of plant. It appears to result in both loosening and tightening of the cell wall [23].
The viscoelastic properties of the primary cell wall are improved by elevating the levels of cell wall remodeling and biosynthetic enzymes, and by modulating the other cell wall loosening agents such as pectin, thus contributing to higher hydration status of the plant which aids up in maintaining turgor pressure necessary for growth [23]. The viscoelastic properties are also modulated by reinforcement of the secondary wall with the accumulation of cellulose and non-cellulosic components. In response to abiotic stress stimuli, the biosynthesis of xyloglucan (the most abundant non-cellulosic components of type I primary walls), and cellulose is induced [24, 25]. It is associated with an up-regulation of EXP (expansin), XTH (xyloglucan endo-β-transglucosylases/hydrolases) and Ces A (Cellulose Synthase) encoding genes [25] Moreover, the comparative analysis of changes in the cell wall of two- different drought-resistant varieties of wheat under stress showed an increase in pectin polymers RGI and RGII (rhamnogalacturonan I and II) side chains that probably leads to hydrogel formation of pectin, limiting the damage to the cells [26]. Also, methyl esterification of homogalacturonan (HG) levels regulated by PME (pectin methylesterase) reduces upon exposure to stress stimuli [27]. Such modifications in the cell wall architecture lead to relative maintenance of cell wall extensibility required to cope up with particular abiotic stress. Moreover, the genes encoding for cell wall proteins including arabinogalactan protein (AGP), glycine-rich protein (GRP), and proline-rich protein (PRP) are also induced in response to abiotic stress that could contribute to the cell wall strengthening [23].
One of the alternative responses against abiotic stress stimuli is to decrease the cell wall expansion and cell extensibility that can thus limit the water loss and prevent cell collapse due to dehydration stress [23, 28]. A decrease in cell wall extensibility or turgor pressure is often associated with the rigidification of the secondary cell wall by lignin deposition. As monolignols are the building blocks of lignin, they are synthesized from phenylalanine through the general phenylpropanoid and monolignol-specific pathways in the cytosol. The monolignols are then transported to the cell wall where they are polymerized by apoplastic peroxidase (PRX) and laccases into lignin [23].
A large number of integral plasma membrane proteins are also known to participate in stress perceptions which are the members of different receptor-like kinases RLKs (receptor-like kinases) [29]. Abiotic stresses are often responsible for alterations in wall-associated kinases (WAK) that are required for cell elongation and development [22]. In plants exposed to abiotic stresses, the expression of genes encoding for WAK proteins is up-regulated hinting towards the perception of stress at the cell wall or plasma membrane interface through the detection of released plant cell wall fragments [24, 30]. Thus, it can be concluded that modulation of the cell wall architecture is often a direct response that plays a vital role in the sensitization of the plant against abiotic stress stimuli. However, critical information on understanding this response comes from transcriptomics rather than biochemical analysis [26]. Therefore, a multidisciplinary approach is required for gaining an in-depth knowledge of this complex mechanism in the future.
Plants suffer numerous physiological reactions on exposure to environmental stress. These responses include alterations in photosynthetic rates, assimilate translocation, nutrient uptake and translocation, changes in water uptake, and evapotranspiration [31]. Among these, photosynthesis is one of the most critical plant processes affected by various abiotic stresses [31, 32]. These stresses negatively influence the photosystems (PS I and PS II) thus reducing the photosynthetic activity along with reduced chlorophyll biosynthesis, and photosynthetic electron transport. They also lead to impaired RuBp (ribulose 1,5-bisphosphate) regeneration that substantially affects the Rubisco activity. Generally, the stress-derived inhibitory effects on photosynthesis in plants may occur due to limitations in CO2diffusion factors and/or metabolic factors. Some reports provide evidence that stomatal closure is the key event under stress conditions resulting in a decrease in the sub-stomatal as well as chloroplast CO2 concentration (Ci and Cc, respectively) thus producing a decline in CO2 assimilation [32, 33, 34, 35, 36].
Under moderate drought stress, decreased stomatal conductance (
Abiotic stresses particularly salt and heavy metal stress are majorly responsible for an imbalance in ionic composition inside the plant cells [10]. For a normal metabolic function of plants, cells need to maintain high K+ and low Na+ levels. Thus, systematic exclusion of excess Na+ ions from the cytoplasm or their accumulation within the vacuoles are the main adaptive mechanisms against ionic stress in plants [21]. This occurs through a highly sophisticated mechanism of ion homeostasis which involves the interplay of different molecular players. Ion homeostasis is maintained by ion pumps like symporters, antiporters, and carrier proteins located on the cell membranes [39]. At the plasma membrane of the cell, the stress signal is perceived by a sensor or a receptor which is generally regulated by the coordination of various ion pumps [40]. Exclusion of ions is typically carried out by transmembrane transport proteins excluding Na+ from the cytosol, however, compartmentalization is carried out by H+- pyrophosphatase proteins and vacuolar membrane H+ -ATPase [12].
Salt Overly Sensitive also known as SOS pathway is an excellent example of intracellular ion management or homeostasis which is turned ‘on’ after the activation of the receptor in response to stress and transcriptional induction of genes by signaling intermediate compounds along with certain downstream interacting partners which result in the efflux of excess ions [41].
In plants, potassium (K+) is one of the most abundant inorganic cations involved in various aspects of plant growth and development including abiotic stress management [44]. Thus, the maintenance of K+ homeostasis through K+ ion transporters and channels across the plasma membrane is necessary for the survival of plants, especially during stress conditions [45]. Plants have developed a unique transport system for K+ acquisition and release using the high-affinity K+ uptake transporters (HKTs) [46]. There are two sub-groups of these transporters (class I and class II) which have been identified to play a critical role in selective Na+ ion transport and cationic co-transport of Na+/K+, respectively [12]. They also play a significant role in the maintenance and distribution of Na+ ions between plant shoots and roots [47]. In
Cl− is a plant micronutrient which regulates turgor pressure, leaf osmotic potential, and stimulates growth in plants by acting as a critical messenger in plant developmental processes [49]. Cl− ion signaling and transporters also regulate different pathways conferring abiotic stress tolerance in plants [50]. For instance, as an early salt stress response, the Cl− ion signal in the soil with elevated salt concentration has been connected to stomatal closure in an ABA dependent manner [21]. However, increased deposition of these ions during ionic stress is detrimental to plant growth and development [51]. Thus, plants tend to decrease the net levels of Cl− ions during stress through reduced net Cl− uptake by roots, decreased intracellular compartmentation, reduced net xylem loading of Cl−, and phloem recirculation and translocation [52]. Also, inside the cytosol, threshold levels of Cl− ions are maintained primarily through its sequestration with the help of ion transporters and voltage-gated ion channels inside the vacuole [53]. A voltage gradient is maintained between the vacuole and the cytoplasm because of a slightly positive charged vacuole and a negatively charged cytoplasm. Hence, a large number of the Cl− ions are sequestered through voltage-gated anion channels of the CLC family which are present on the tonoplast. Different CLC proteins function as anion/H+ exchangers or anion-selective channels. In reports, AtCLCa has been characterized as a two-anion/H+ exchanger which drives the active uptake of anions inside the vacuoles of Arabidopsis guard cells and mesophyll with higher selectivity for NO3− ions over Cl− ions [54]. Besides, CLCs play a vital role in loading anions in the vacuole of guard cells for stomatal opening in response to light and later releasing them during ABA-induced stomatal closure [55].
The intracellular water loss from the cell due to drought and salinity stress results in cellular dehydration thus imposing osmotic stress in plants [56]. To counteract the effects of osmotic stress, plants and bacteria accumulate certain organic solutes like quaternary ammonium compounds, polyamines, fructose, sucrose, sugar alcohols, trehalose, fructans, oxalate, malate, and many others. These metabolites are referred as osmoprotectants or compatible solutes and may accumulate in large quantities without disturbing the intracellular biochemistry [57]. Among these osmoprotectants, quaternary ammonium compounds including proline and glycine betaine (GB) abundantly accumulate in response to abiotic stresses. The imino acid proline is known to be deposited in considerable amounts in plant cells under the influence of drought, salinity, and other stresses [58]. It is synthesized inside the cytoplasm and plastids while it is degraded to glutamate (Glu) in the mitochondria. In addition to its role in osmotic adjustment, proline contributes in the stabilization of the cellular membranes and vital proteins by making clusters with water molecules that later get attached to membranes and proteins, thus, inhibiting their denaturation [59, 60]. Proline also scavenges free radicals to maintain or buffer the redox potential inside the cell under stressful conditions. It alleviates the cytoplasmic acidosis and sustains NADP+/NADPH ratios at required levels for cellular metabolism, hence, supporting redox cycling [60, 61]. Researchers have observed a positive correlation between proline deposition and tolerance against various abiotic stresses in plants [58]. Furthermore, the exogenous application of proline has been used as an effective approach to improve stress tolerance in plants [62].
GB is another critical compound that plays an important role in osmoprotection, stroma adjustment as well as protection of thylakoid membranes for maintaining the photosynthetic activity during stress conditions [63, 64]. It protects the photosystem II (PS-II) complex from the impact of abiotic stresses [65]. GB also possesses a protective role for Rubisco against heat-induced destabilization [65]. The increased accumulation of GB provides abiotic stress resistance in several agronomically important crops including tobacco, potato, tomato, barley, and maize [11, 66, 67]. Moreover, the
The content of soluble carbohydrates also varies in response to abiotic stresses in plants. Simple and complex carbohydrates such as sugars, starch, and sugar alcohols accumulate under stress conditions in plants [68]. The major roles of these biomolecules are osmotic adjustment, carbon storage, and free radical scavenging. Their pattern of accumulation in response to stress varies under short- and long-term reactions. In short-term water stress conditions, decreased content of sucrose and starch were observed in the case of
Polyamines are small organic molecules ubiquitously present in all living organisms which play a vital role in diverse cellular processes. They are positively charged at physiological pH and are regarded as growth substances [73, 74, 75]. Under stress conditions, different plant species respond differently to polyamines levels. Some of the plants might increase the content of polyamines under stress conditions whereas others decrease their levels of endogenous polyamines when exposed to severe environmental conditions [73]. Exogenous application of polyamine and/or inhibitors of enzymes which are involved in polyamine biosynthesis also hints towards a possible role of such compounds in plant adaptation or defense process in response to environmental stresses [76]. Moreover, studies involving either transgenic overexpression or loss of function mutants support the protective, adaptive, or defensive role of polyamines in plant’s response to various abiotic stresses [76, 77].
Many evidences suggest that various environmental stresses lead to the generation of ROS in plants. Actually, in plants, each cellular compartment is equipped with its own ROS homeostasis control [78, 79, 80]. The ROS signaling is changed depending upon the cell type, developmental stage, and level of stress [81]. Under optimal growth conditions, ROS inside the cell is mainly produced at a low level in organelles like chloroplast, mitochondria, and peroxisomes [82]. It has been estimated that 1–2% of the O2 consumed by plant tissues, leads to the ROS formation that mainly involves 1O2, H2O2, O•−2, and OH• [83, 84]. At this low concentration, ROS acts as a signaling molecule that triggers signal transduction pathways involved in growth and development [21, 85]. However, in response to various abiotic stresses, the generation of increased levels of ROS causes irreversible damage to cells through their strong oxidative properties [86]. They possess lethal properties and cause extensive damage to DNA, proteins, and lipids thereby affecting normal cellular functioning [82]. Plants have developed an elaborate and efficient network of ROS generating and scavenging mechanisms to overcome this ROS toxicity. The two systems interplay with each other for maintaining a steady state in plants during stress acclimation [87, 88]. The delicate balance between the generation of ROS and its scavenging is responsible for duality in its function in plants which is orchestrated by a giant network of genes known as ‘ROS gene network’ [84].
Plant NADPH oxidases also referred as respiratory burst oxidase homologs (RBOHs) are the most studied enzymatic source of ROS in plants [88]. These are superoxide-producing enzymes that are widely involved in various processes including abiotic stress responses in plants [89]. The superoxide radical is a short-lived ROS molecule that is characterized by moderate reactivity and can trigger a series of reactions to produce other ROS species. It is produced inside mitochondria, chloroplasts, endoplasmic reticulum, and peroxisomes as a result of their normal metabolism [90]. The activity of plant NADPH oxidase is regulated by some key regulatory components like Ca2+, calcium-dependent protein kinases (CDPKs), Ca2+/CaM-dependent protein kinase, some small GTPases, and others. The production of ROS through NADPH oxidase may result in regulating the acclimation to abiotic stresses in plants. For instance, in barley, NADPH oxidase-mediated apoplastic ROS generation (acting upstream of xylem Na+ loading) that is linked to ROS-inducible Ca2+ uptake systems in the xylem parenchyma tissue is considered as a critical factor contributing to salt stress tolerance in plants [91]. In
Superoxide ions generated by NADPH oxidase are converted to hydrogen peroxide (H2O2), catalyzed by the different isoforms of superoxide dismutase (SOD) enzyme [93]. H2O2 production in plant cells not only occurs under normal conditions but also by oxidative stress which is caused by different abiotic factors. The major sources of H2O2 production in plant cells comprises of the electron transport chain in the chloroplast, endoplasmic reticulum (ER), mitochondria, cell membrane, β-oxidation of fatty acid, and photorespiration along with various other sources including reactions comprising photo-oxidation by NADPH oxidase. The rates of H2O2 accumulation in peroxisomes, as well as chloroplasts, may be 30–100 times higher as compared with H2O2 generated in the mitochondria. It acts as a systemic signal that alerts various plant tissues to respond and adapt in response to the upcoming stress stimuli [94, 95]. H2O2 confer acclamatory stress tolerance by regulating osmotic adjustment, photosynthesis, ROS detoxification, and phytohormones signaling [95]. Studies have suggested that seeds pre-treated with H2O2, or together with the application of H2O2 and abiotic stress, induce an inductive pulse which aids up in protecting plants under abiotic stresses by the restoration of redox-homeostasis and mitigation of oxidative damage to membranes, lipids, and proteins by modulating the stress signaling pathways [95].
The stress-induced ROS activating responses occur rapidly with the appearance of the stress and it should decay immediately to protect the plants against their toxic effects. For this, plants are equipped with an array of ROS detoxifying proteins that mitigate the toxic effects of ROS generated as a result of different types of stresses [96]. In plants, the redox homeostasis during stressful conditions is maintained by the two arms of the antioxidant machinery—the enzymatic components consisting of the superoxide dismutase (SOD), guaiacol peroxidase (GPX), ascorbate peroxidase (APX), catalase (CAT), glutathione-S-transferase (GST), and the non-enzymatic molecular compounds like reduced glutathione (GSH), ascorbic acid (AA), α-tocopherol, phenolics, carotenoids, flavonoids, and proline. These antioxidant enzymes are situated in different sites of the plant cells and work together to detoxify ROS. The omnipresent behavior of both arms of the antioxidant machinery explains the basic necessity of detoxification of ROS for cell survival [97].
Various strategies have been undertaken by the researchers from time to time to improve the abiotic stress tolerance in plants, particularly crop plants [98]. Plant breeding is the most traditional and widely used method for achieving the desired trait in given plants including stress adaptation [99]. However, the success of crop-breeding programs greatly depends on the availability of natural genetic variations among the germplasm resources and tedious selection procedures that are too slow and equally expensive [100]. Moreover, the various environmental factors such as plant developmental stage along with the logistical constraints of physiological screening of large breeding populations on a field-scale can affect the differential selection of a particular stress tolerant plant. Thus, plant breeding is almost always limited by the genetic complexity of the underpinning mechanisms along with the potential interaction among genetic determinants [101]. In this regard, the identification and recognition of discrete chromosomal regions having a major effect on the specific tolerance trait via quantitative trait loci (QTL) mapping and marker-assisted selection remain a valuable option for the success of many breeding programs [102]. Although, QTL mapping holds great promise, but still it remains complicated as the introgression of QTL regions in elite lines is tedious due to linkage drag that may introduce non-target regions. As an alternative, the cellular-based mutant introduction and subsequent selection under controlled
In the past few decades, the genetic engineering approach has attracted the interest of the research community for producing stress-tolerant elite crops [104]. Genetic transformation with stress-inducible genes has been employed by the researchers to gain an understanding of their functional role in stress tolerance and ultimately to improve the traits in the target genotype [105]. The genetic manipulation techniques including insertional mutagenesis have largely contributed to deciphering the function of genes and thereby identifying the suitable candidates for crop improvement [106]. However, though success has been achieved in introducing desired tolerance traits into various crop varieties from wild relatives like barley and tomato, a restricted success has been reported in achieving abiotic stress tolerance with elite germplasm [107]. Moreover, the integration of transgenes into the host genome is sometimes non-specific and unstable [108]. Recently, the use of targeted genome editing using clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated protein9 nuclease (Cas9) (CRISPR/Cas) has generated a lot of interest in various fields of plant biology including abiotic stress management [109]. CRISPR/Cas has been adopted in the field of plant developmental biology for characterizing genes as well as to underpin the molecular mechanisms behind various plant traits [110]. It has been used in the model plants such as Arabidopsis and tobacco earlier and likewise, now it is being utilized effectively for crop plants like sorghum, rice, wheat, maize, soybean as well as woody plants. Researchers have worked on the potential use of the CRISPR/Cas9 technique for the production of abiotic stress-tolerant crops by targeting the key sensitivity (
In the last few decades, significant progress has been made in our understanding of the complex mechanisms governing abiotic stress tolerance in plants. However, still we are far from pinning the exact battery of gene activation mechanisms responsible for providing tolerance to various abiotic stresses. Our struggle to understand the complex mechanisms is ongoing and recent development of new tools for high-throughput phenotyping and genotyping gives us a new ray of hope. A complete understanding of the physiological, biochemical and molecular mechanisms especially the signaling cascades in response to abiotic stresses in tolerant plants will help to manipulate susceptible crop plants and increase agricultural productivity in the near future. Moreover, advances in genomics strategies including genetic engineering and genome editing have provided new opportunities for crop improvement by employing precise genome engineering for targeted traits in crop plants. However, the selection of the key genes is critical for the success of these approaches.
Authors are thankful to the Department of Biotechnology, GOI, and Rashtriya Uchchattar Shiksha Abhiyan (RUSA-II) Program, Ministry of Human Resource Development (MHRD), GOI.
The authors declare no conflict of interest.
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