Experimental Animal Models of Human Diseases

Ibeh Bartholomew

doi:10.5772/66030

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Open access peer-reviewed Edited Volume

An Effective Therapeutic Strategy

Edited by Bartholomew Ibeh

The world has recorded losses in terms of human life as well as extensive time spent in experimentation with development of new drugs, elucidation of disease mechanism(s), and therapeutic agent discovery. Ethical and legal issues cojoin in slowing down scientific discoveries in medicine and biology. The past two (2) decades, therefore, have seen tremendous attempts that largely are successful in developing animal models with the characteristics of mimicking, approximating, or expressing transplanted human organs/tissues. These models or rather approaches seem to be fast, cost-effective, and easy to maintain compared to primates. This book is a collection of expert essays on animal models of human diseases of global interest. A visible objective of the book is to provide real-time experimental approach to scientists, clinicians, ethicists, medicolegal/medical jurisprudence workers, immunologists, postgraduate students, and vaccinologists and informative and multidisciplinary approach for the identification of new therapeutic targets and biomarkers using animal models as well as investigating the pathogenesis and therapeutic strategies of human diseases. An increased understanding of the genetic, molecular, and cellular mechanisms responsible for the development of human diseases has laid out the foundation for the development of rational therapies mainly with animal models.

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Experimental Animal Models of Human DiseasesAn Effective Therapeutic StrategyEdited by Bartholomew Ibeh

Published: May 23rd 2018

DOI: 10.5772/66030

ISBN: 978-1-78923-165-6

Print ISBN: 978-1-78923-164-9

eBook (PDF) ISBN: 978-1-83881-260-7

Books open for chapter submissions

8647 Total Chapter Downloads

8 Crossref Citations

10 Dimensions Citations

chapters		Downloads
Open access peer-reviewed 1. Introductory Chapter: Animal Models for Human Diseases, a Major Contributor to Modern Medicine By Ibeh Bartholomew Okechukwu		529
Open access peer-reviewed 2. Animal Models of Diabetic Retinopathy (Part 1) By Larissa H.C. Tang, Ian Y.H. Wong and Amy C.Y. Lo		387
Open access peer-reviewed 3. Animal Models of Diabetic Retinopathy (Part 2) By Larissa H.C. Tang, Ian Y.H. Wong and Amy C.Y. Lo		371
Open access peer-reviewed 4. Animal Models of Central Diabetes Insipidus: Oxytocin and Low-Sodium Diets as Complementary Treatments By Antonio Bernal, Javier Mahía and Amadeo Puerto		339
Open access peer-reviewed 5. Animal Models of Obesity Characterized by Non-alcoholic Fatty Liver Disease (NAFLD) By Melina Ribeiro Fernandes, Priscila Silva Figueiredo, Karoline Silva Rezende, Karine de Cássia Freitas, Priscila Aiko Hiane and Rita de Cássia Avellaneda Guimarães		908
Open access peer-reviewed 6. Rodent Models of Obesity and Diabetes By María José Hernández-Granados, Joel Ramírez-Emiliano and Elena Franco-Robles		336
Open access peer-reviewed 7. Animal Models of Double Incontinence: “Fecal and Urinary” By Raheela Mohsin Rizvi and Sanam Imtiaz		286
Open access peer-reviewed 8. Relevance of the CDE and DDC Mouse Models to Study Ductular Reaction in Chronic Human Liver Diseases By Laure-Alix Clerbaux, Noémi Van Hul, Annette S.H. Gouw, Rita Manco, Regina Español-Suñer and Isabelle A. Leclercq		389
Open access peer-reviewed 9. Experimental Animal Models of HIV/AIDS for Vaccine Trials By Bartholomew Okechukwu Ibeh and Efejiro Ashano		1400
Open access peer-reviewed 10. Animal Inhalation Models to Investigate Modulation of Inflammatory Bowel Diseases By Giuseppe Lo Sasso, Walter K. Schlage, Blaine Phillips, Manuel C. Peitsch and Julia Hoeng		478
Open access peer-reviewed 11. Use of Animal Models in the Study of Colitis By Karoline S. Rezende, Melina R. Fernandes, Bernardo B. de Faria, Rita C. A. Guimarães and Karine C. Freitas		483
Open access peer-reviewed 12. Evaluation of Animal Models Suitable for Hair Research and Regeneration By Meda Sandra Orăsan and Andrei Coneac		493
Open access peer-reviewed 13. Animal Models of Rheumatoid Arthritis By María Eugenia Castañeda-Lopez, Idalia Garza-Veloz, José Manuel Ortiz-Rodriguez, Rodrigo Castañeda-Miranda, Luis Octavio Solis- Sanchez, Héctor Rene Vega-Carrillo, María del Rosario Martinez- Blanco, Fabiola Trejo-Vazquez, Gerardo Ornelas-Vargas, Iram Pablo Rodriguez-Sanchez, Héctor Alonso Guerrero-Osuna, Iván Delgado- Enciso, Oscar Gustavo Meza-Zavala and Margarita de la Luz Martinez-Fierro		532
Open access peer-reviewed 14. Animal Models for Chronic Stress-Induced Oxidative Stress in the Spleen: The Role of Exercise and Catecholaminergic System By Ljubica Gavrilović, Vesna Stojiljković, Nataša Popović, Snežana Pejić, Ana Todorović, Ivan Pavlović and Snežana B. Pajović		324
Open access peer-reviewed 15. Studying Side Effects of Tyrosine Kinase Inhibitors in a Juvenile Rat Model with Focus on Skeletal Remodeling By Josephine T. Tauer, Bernadette A. S. Jäger, Anna Ulmer, Paula Geidel, Vera Girke, Lysann Kroschwald and Meinolf Suttorp		310
Open access peer-reviewed 16. Animal Models of Fetal Medicine and Obstetrics By Maria Dahl Andersen, Aage Kristian Olsen Alstrup, Christina Søndergaard Duvald, Emmeli Fredsgaard Ravnkilde Mikkelsen, Mikkel Holm Vendelbo, Per Glud Ovesen and Michael Pedersen		640
Open access peer-reviewed 17. Animal Model of Parkinson Disease: Neuroinflammation and Apoptosis in the 6-Hydroxydopamine-Induced Model By Daniel Hernandez-Baltazar, Rasajna Nadella, Maria de Jesus Rovirosa-Hernandez, Laura Mireya Zavala-Flores and Christian de Jesus Rosas Jarquin		449

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