Open access peer-reviewed Edited Volume

Experimental Animal Models of Human Diseases

An Effective Therapeutic Strategy

The world has recorded losses in terms of human life as well as extensive time spent in experimentation with development of new drugs, elucidation of disease mechanism(s), and therapeutic agent discovery. Ethical and legal issues cojoin in slowing down scientific discoveries in medicine and biology. The past two (2) decades, therefore, have seen tremendous attempts that largely are successful in developing animal models with the characteristics of mimicking, approximating, or expressing transplanted human organs/tissues. These models or rather approaches seem to be fast, cost-effective, and easy to maintain compared to primates. This book is a collection of expert essays on animal models of human diseases of global interest. A visible objective of the book is to provide real-time experimental approach to scientists, clinicians, ethicists, medicolegal/medical jurisprudence workers, immunologists, postgraduate students, and vaccinologists and informative and multidisciplinary approach for the identification of new therapeutic targets and biomarkers using animal models as well as investigating the pathogenesis and therapeutic strategies of human diseases. An increased understanding of the genetic, molecular, and cellular mechanisms responsible for the development of human diseases has laid out the foundation for the development of rational therapies mainly with animal models.

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Experimental Animal Models of Human DiseasesAn Effective Therapeutic StrategyEdited by Bartholomew Ibeh

Published: May 23rd 2018

DOI: 10.5772/66030

ISBN: 978-1-78923-165-6

Print ISBN: 978-1-78923-164-9

eBook (PDF) ISBN: 978-1-83881-260-7

Copyright year: 2018

Books open for chapter submissions

22557 Total Chapter Downloads

22 Crossref Citations

15 Web of Science Citations

36 Dimensions Citations


Open access peer-reviewed

1. Introductory Chapter: Animal Models for Human Diseases, a Major Contributor to Modern Medicine

By Ibeh Bartholomew Okechukwu


Open access peer-reviewed

2. Animal Models of Diabetic Retinopathy (Part 1)

By Larissa H.C. Tang, Ian Y.H. Wong and Amy C.Y. Lo


Open access peer-reviewed

3. Animal Models of Diabetic Retinopathy (Part 2)

By Larissa H.C. Tang, Ian Y.H. Wong and Amy C.Y. Lo


Open access peer-reviewed

4. Animal Models of Central Diabetes Insipidus: Oxytocin and Low-Sodium Diets as Complementary Treatments

By Antonio Bernal, Javier Mahía and Amadeo Puerto


Open access peer-reviewed

5. Animal Models of Obesity Characterized by Non-alcoholic Fatty Liver Disease (NAFLD)

By Melina Ribeiro Fernandes, Priscila Silva Figueiredo, Karoline Silva Rezende, Karine de Cássia Freitas, Priscila Aiko Hiane and Rita de Cássia Avellaneda Guimarães


Open access peer-reviewed

6. Rodent Models of Obesity and Diabetes

By María José Hernández-Granados, Joel Ramírez-Emiliano and Elena Franco-Robles


Open access peer-reviewed

7. Animal Models of Double Incontinence: “Fecal and Urinary”

By Raheela Mohsin Rizvi and Sanam Imtiaz


Open access peer-reviewed

8. Relevance of the CDE and DDC Mouse Models to Study Ductular Reaction in Chronic Human Liver Diseases

By Laure-Alix Clerbaux, Noémi Van Hul, Annette S.H. Gouw, Rita Manco, Regina Español-Suñer and Isabelle A. Leclercq


Open access peer-reviewed

9. Experimental Animal Models of HIV/AIDS for Vaccine Trials

By Bartholomew Okechukwu Ibeh and Efejiro Ashano


Open access peer-reviewed

10. Animal Inhalation Models to Investigate Modulation of Inflammatory Bowel Diseases

By Giuseppe Lo Sasso, Walter K. Schlage, Blaine Phillips, Manuel C. Peitsch and Julia Hoeng


Open access peer-reviewed

11. Use of Animal Models in the Study of Colitis

By Karoline S. Rezende, Melina R. Fernandes, Bernardo B. de Faria, Rita C. A. Guimarães and Karine C. Freitas


Open access peer-reviewed

12. Evaluation of Animal Models Suitable for Hair Research and Regeneration

By Meda Sandra Orăsan and Andrei Coneac


Open access peer-reviewed

13. Animal Models of Rheumatoid Arthritis

By María Eugenia Castañeda-Lopez, Idalia Garza-Veloz, José Manuel Ortiz-Rodriguez, Rodrigo Castañeda-Miranda, Luis Octavio Solis- Sanchez, Héctor Rene Vega-Carrillo, María del Rosario Martinez- Blanco, Fabiola Trejo-Vazquez, Gerardo Ornelas-Vargas, Iram Pablo Rodriguez-Sanchez, Héctor Alonso Guerrero-Osuna, Iván Delgado- Enciso, Oscar Gustavo Meza-Zavala and Margarita de la Luz Martinez-Fierro


Open access peer-reviewed

14. Animal Models for Chronic Stress-Induced Oxidative Stress in the Spleen: The Role of Exercise and Catecholaminergic System

By Ljubica Gavrilović, Vesna Stojiljković, Nataša Popović, Snežana Pejić, Ana Todorović, Ivan Pavlović and Snežana B. Pajović


Open access peer-reviewed

15. Studying Side Effects of Tyrosine Kinase Inhibitors in a Juvenile Rat Model with Focus on Skeletal Remodeling

By Josephine T. Tauer, Bernadette A. S. Jäger, Anna Ulmer, Paula Geidel, Vera Girke, Lysann Kroschwald and Meinolf Suttorp


Open access peer-reviewed

16. Animal Models of Fetal Medicine and Obstetrics

By Maria Dahl Andersen, Aage Kristian Olsen Alstrup, Christina Søndergaard Duvald, Emmeli Fredsgaard Ravnkilde Mikkelsen, Mikkel Holm Vendelbo, Per Glud Ovesen and Michael Pedersen


Open access peer-reviewed

17. Animal Model of Parkinson Disease: Neuroinflammation and Apoptosis in the 6-Hydroxydopamine-Induced Model

By Daniel Hernandez-Baltazar, Rasajna Nadella, Maria de Jesus Rovirosa-Hernandez, Laura Mireya Zavala-Flores and Christian de Jesus Rosas Jarquin


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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