Open access peer-reviewed Edited Volume

Drug Development

A Case Study Based Insight into Modern Strategies

This book represents a case study based overview of many different aspects of drug development, ranging from target identification and characterization to chemical optimization for efficacy and safety, as well as bioproduction of natural products utilizing for example lichen. In the last section, special aspects of the formal drug development process are discussed. Since drug development is a highly complex multidisciplinary process, case studies are an excellent tool to obtain insight in this field. While each chapter gives specific insight and may be read as an independent source of information, the whole book represents a unique collection of different facets giving insight in the complexity of drug development.

Read more >Order hardcopy
IntechOpen
Drug DevelopmentA Case Study Based Insight into Modern StrategiesEdited by Chris Rundfeldt

Published: December 7th 2011

DOI: 10.5772/2435

ISBN: 978-953-307-257-9

eBook (PDF) ISBN: 978-953-51-4392-5

Copyright year: 2011

Books open for chapter submissions

78604 Total Chapter Downloads

16 Crossref Citations

62 Web of Science Citations

62 Dimensions Citations

chaptersDownloads

Open access peer-reviewed

1. Discovery and Optimization of Inhibitors of DNA Methyltransferase as Novel Drugs for Cancer Therapy

By Jakyung Yoo and José L. Medina-Franco

3321

Open access peer-reviewed

2. Development of Novel Secondary Hormonal Therapies for Castrate-Resistant Prostate Cancer

By Rahul Aggarwal and Charles J. Ryan

1953

Open access peer-reviewed

3. Inhibitors of Proteinases as Potential Anti-Cancer Agents

By Karolina Gluza and Paweł Kafarski

2256

Open access peer-reviewed

4. Histamine Receptors as Potential Therapeutic Targets for Cancer Drug Development

By Vanina A. Medina, Diego J. Martinel Lamas, Pablo G. Brenzoni, Noelia Massari, Eliana Carabajal and Elena S. Rivera

3477

Open access peer-reviewed

5. Histone Deacetylase Inhibitors as Therapeutic Agents for Cancer Therapy: Drug Metabolism and Pharmacokinetic Properties

By Ethirajulu Kantharaj and Ramesh Jayaraman

4706

Open access peer-reviewed

6. Antimicrobial Peptides: New Frontiers in the Therapy of Infections

By Mario Zucca, Sara Scutera and Dianella Savoia

4761

Open access peer-reviewed

7. microRNAs as Therapeutic Targets to Combat Diverse Human Diseases

By Elizabeth Hong-Geller and Nan Li

1699

Open access peer-reviewed

8. Potentiation of Available Antibiotics by Targeting Resistance – An Emerging Trend in Tuberculosis Drug Development

By Kerstin A. Wolff, Marissa Sherman and Liem Nguyen

2127

Open access peer-reviewed

9. Antitubercular Drugs Development: Recent Advances in Selected Therapeutic Targets and Rational Drug Design

By Virgilio Bocanegra-García, Abraham García, Jose Prisco Palma-Nicolás, Isidro Palos and Gildardo Rivera

8160

Open access peer-reviewed

10. Insight into the Key Structural Features of Potent Enoyl Acyl Carrier Protein Reductase Inhibitors Based on Computer Aided Molecular Design

By Auradee Punkvang, Pharit Kamsri, Kodchakon Kun-asa, Patchreenart Saparpakorn, Supa Hannongbua, Peter Wolschann and Pornpan Pungpo

1874

Open access peer-reviewed

11. RNA Interference-Based Therapeutics: Harnessing the Powers of Nature

By Tamara Martinez, Natalia Wright, Covadonga Paneda, Ana I. Jimenez and Marta Lopez-Fraga

2219

Open access peer-reviewed

12. P2X Receptors as New Therapeutic Targets

By Liang Xin, Xiao Yanjuan and Li Zhiyuan

3736

Open access peer-reviewed

13. Pregnane X Receptor in Drug Development

By Su Sien Ong, Yue-Ming Wang, Sergio C. Chai and Taosheng Chen

4061

Open access peer-reviewed

14. Crosstalk Between the Immune and Central Nervous Systems with Special Reference to Drug Development

By Takekazu Kubo, Shigeru Tokita and Toshihide Yamashita

1850

Open access peer-reviewed

15. Liquiritigenin Attenuates Alzheimer’s-Like Neuropathology in an Amyloid Protein Precursor Transgenic Mouse Model and the Underlying Mechanisms

By Rui Ting Liu, Jin Tian Tang, Li Bo Zou, Jie Ying Fu and Qiu Jun Lu

1840

Open access peer-reviewed

16. Novel Therapeutic Strategies for Chagas` Disease

By Alane Beatriz Vermelho, Carlos Alberto Manssour Fraga, Samir Aquino Carvalho, Edson Ferreira da Silva, Solange Lisboa de Castro, Igor de Almeida Rodrigues, Maria do Socorro dos Santos Rosa, Ana Claudia Fernandes Amaral and Giseli Capaci Rodrigues

2854

Open access peer-reviewed

17. The Gut Microbiota as Target for Innovative Drug Development: Perspectives and a Case Study of Inflammatory Bowel Diseases

By Joan Vermeiren, Sam Possemiers, Massimo Marzorati and Tom Van de Wiele

3003

Open access peer-reviewed

18. Endophytic Fungi of Tropical Forests: A Promising Source of Bioactive Prototype Molecules for the Treatment of Neglected Diseases

By Luiz H. Rosa, Mariana L.A. Vieira, Betania B. Cota, Susana Johann,Tânia M.A. Alves, Carlos L. Zani and Carlos A. Rosa

4431

Open access peer-reviewed

19. Bioproduction of Depsidones for Pharmaceutical Purposes

By María Estrella Legaz, Roberto de Armas and Carlos Vicente

2743

Open access peer-reviewed

20. Multi-Dose Container for Nasal and Ophthalmic Drugs: A Preservative Free Future?

By Degenhard Marx and Matthias Birkhoff

5333

Open access peer-reviewed

21. Microneedle-Assisted Transdermal Delivery of Opioid Antagonists for the Treatment of Alcoholism

By Stan L. Banks, Audra L. Stinchcomb and Kalpana S. Paudel

2240

Open access peer-reviewed

22. Innovative Proposals for Incentivizing Drug Development

By Kristina M. Lybecker

1927

Open access peer-reviewed

23. Drug Experimentation in Healthy Volunteers

By Giovanni Gori, Giuseppe Pasqualetti, Catia Castiglioni, Corrado Blandizzi and Mario Del Tacca

5061

Open access peer-reviewed

24. Changes in Research and Development of Medicinal Products since the Paediatric Regulation

By Adriana Ceci, Mariana Catapano, Cristina Manfredi, Ian Wong, Mine Orlu-Gul, Annarita Meneguz, Paola Baiardi, Oscar Della Pasqua, Achille Iolascon, Maurizio Scarpa and Antje Neubert

2974

Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI
  • BKCI
  • BIOSIS Previews

Order a hardcopy of the Edited Volume

Free shipping with DHL Express

Hardcover (ex. VAT)£159

Order now

Residents of European Union countries need to add a Book Value-Added Tax of 5%. Institutions and companies, registered as VAT taxable entities in their own EU member state, will not pay VAT by providing IntechOpen with their VAT registration number. This is made possible by the EU reverse charge method.

Special discount for IntechOpen contributors

All IntechOpen contributors are offered special discounts starting at 40% OFF available through your personal dashboard

Login and purchase