Open access peer-reviewed Edited volume

Computational Biology and Applied Bioinformatics

Nowadays it is difficult to imagine an area of knowledge that can continue developing without the use of computers and informatics. It is not different with biology, that has seen an unpredictable growth in recent decades, with the rise of a new discipline, bioinformatics, bringing together molecular biology, biotechnology and information technology. More recently, the development of high throughput techniques, such as microarray, mass spectrometry and DNA sequencing, has increased the need of computational support to collect, store, retrieve, analyze, and correlate huge data sets of complex information. On the other hand, the growth of the computational power for processing and storage has also increased the necessity for deeper knowledge in the field. The development of bioinformatics has allowed now the emergence of systems biology, the study of the interactions between the components of a biological system, and how these interactions give rise to the function and behavior of a living being. This book presents some theoretical issues, reviews, and a variety of bioinformatics applications. For better understanding, the chapters were grouped in two parts. In Part I, the chapters are more oriented towards literature review and theoretical issues. Part II consists of application-oriented chapters that report case studies in which a specific biological problem is treated with bioinformatics tools.

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Computational Biology and Applied BioinformaticsEdited by Heitor Lopes

Published: September 2nd 2011

DOI: 10.5772/772

ISBN: 978-953-307-629-4

Books open for chapter submissions

42095 Total Chapter Downloads

8 Crossref Citations

16 Web of Science Citations

24 Dimensions Citations

chaptersDownloads

Open access peer-reviewed

1. Molecular Evolution & Phylogeny: What, When, Why & How?

By Pandurang Kolekar, Mohan Kale and Urmila Kulkarni-Kale

3821

Open access peer-reviewed

2. Understanding Protein Function - The Disparity Between Bioinformatics and Molecular Methods

By Katarzyna Hupert-Kocurek and Jon M. Kaguni

1911

Open access peer-reviewed

3. In Silico Identification of Regulatory Elements in Promoters

By Vikrant Nain, Shakti Sahi and Polumetla Ananda Kumar

2996

Open access peer-reviewed

4. In Silico Analysis of Golgi Glycosyltransferases: A Case Study on the LARGE-Like Protein Family

By Kuo-Yuan Hwa, Wan-Man Lin and Boopathi Subramani

1807

Open access peer-reviewed

5. MicroArray Technology - Expression Profiling of MRNA and MicroRNA in Breast Cancer

By Aoife Lowery, Christophe Lemetre, Graham Ball and Michael Kerin

1706

Open access peer-reviewed

6. Computational Tools for Identification of microRNAs in Deep Sequencing Data Sets

By Manuel A. S. Santos and Ana Raquel Soares

2193

Open access peer-reviewed

7. Computational Methods in Mass Spectrometry-Based Protein 3D Studies

By Rosa M. Vitale, Giovanni Renzone, Andrea Scaloni and Pietro Amodeo

1851

Open access peer-reviewed

8. Synthetic Biology & Bioinformatics Prospects in the Cancer Arena

By Lígia R. Rodrigues and Leon D. Kluskens

1732

Open access peer-reviewed

9. An Overview of Hardware-Based Acceleration of Biological Sequence Alignment

By Laiq Hasan and Zaid Al-Ars

1702

Open access peer-reviewed

10. Retrieving and Categorizing Bioinformatics Publications through a MultiAgent System

By Andrea Addis, Giuliano Armano, Eloisa Vargiu and Andrea Manconi

1168

Open access peer-reviewed

11. GRID Computing and Computational Immunology

By Ferdinando Chiacchio and Francesco Pappalardo

1302

Open access peer-reviewed

12. A Comparative Study of Machine Learning and Evolutionary Computation Approaches for Protein Secondary Structure Classification

By César Manuel Vargas Benítez, Chidambaram Chidambaram, Fernanda Hembecker and Heitor Silvério Lopes

1700

Open access peer-reviewed

13. Functional Analysis of the Cervical Carcinoma Transcriptome: Networks and New Genes Associated to Cancer

By Mauricio Salcedo, Sergio Juarez-Mendez, Vanessa Villegas-Ruiz, Hugo Arreola, Oscar Perez, Guillermo Gómez, Edgar Roman-Bassaure, Pablo Romero, Raúl Peralta

1961

Open access peer-reviewed

14. Number Distribution of Transmembrane Helices in Prokaryote Genomes

By Ryusuke Sawada and Shigeki Mitaku

1502

Open access peer-reviewed

15. Classifying TIM Barrel Protein Domain Structure by an Alignment Approach Using Best Hit Strategy and PSI-BLAST

By Chia-Han Chu, Chun Yuan Lin, Cheng-Wen Chang, Chihan Lee and Chuan Yi Tang

1366

Open access peer-reviewed

16. Identification of Functional Diversity in the Enolase Superfamily Proteins

By Kaiser Jamil and M. Sabeena

1282

Open access peer-reviewed

17. Contributions of Structure Comparison Methods to the Protein Structure Prediction Field

By David Piedra, Marco d'Abramo and Xavier de la Cruz

1418

Open access peer-reviewed

18. Functional Analysis of Intergenic Regions for Gene Discovery

By Li M. Fu

1839

Open access peer-reviewed

19. Prediction of Transcriptional Regulatory Networks for Retinal Development

By Ying Li, Haiyan Huang and Li Cai

1589

Open access peer-reviewed

20. The Use of Functional Genomics in Synthetic Promoter Design

By Michael L. Roberts

2524

Open access peer-reviewed

21. Analysis of Transcriptomic and Proteomic Data in Immune-Mediated Diseases

By Sergey Bruskin, Alex Ishkin, Yuri Nikolsky, Tatiana Nikolskaya and Eleonora Piruzian

1555

Open access peer-reviewed

22. Emergence of the Diversified Short ORFeome by Mass Spectrometry-Based Proteomics

By Hiroko Ao-Kondo, Hiroko Kozuka-Hata and Masaaki Oyama

1423

Open access peer-reviewed

23. Acrylamide Binding to Its Cellular Targets: Insights from Computational Studies

By Emmanuela Ferreira de Lima and Paolo Carloni

1747

Edited volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI
  • IET Inspec

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