Open access peer-reviewed Edited Volume

Colorectal Cancer

From Pathogenesis to Treatment

Edited by Luis Rodrigo

University of Oviedo

Colorectal cancer (CRC) is a major health problem because it represents around 10% of all cancers and achieves a worldwide estimate of 1.4 million newly diagnosed cases annually, resulting in approximately 700,000 deaths. Approximately 19-31% of patients present liver metastases. At diagnosis, a further 23-38% will develop extra-hepatic disease. Over the past decade, the widespread use of modern chemotherapeutic and biological agents, combined with laparoscopic surgical techniques, has improved the prognosis of metastatic CRC. A better understanding of the biology of the tumor, along with high efficiency of diagnostic and therapeutic methods, as well as the spread of screening programs, will improve the survival of the CRC patients in the near future.

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Colorectal CancerFrom Pathogenesis to TreatmentEdited by Luis Rodrigo

Published: September 7th 2016

DOI: 10.5772/61359

ISBN: 978-953-51-2545-7

Print ISBN: 978-953-51-2544-0

eBook (PDF) ISBN: 978-953-51-4184-6

Copyright year: 2016

Books open for chapter submissions

30711 Total Chapter Downloads

14 Crossref Citations

7 Web of Science Citations

22 Dimensions Citations


Open access peer-reviewed

1. Molecular Mechanisms Involved in the Acquisition of Resistance to Treatment of Colon Cancer Cells

By Dora M. Velázquez, María Cristina Castañeda-Patlán and Martha Robles-Flores


Open access peer-reviewed

2. Circadian Regulation of Colon Cancer Stem Cells: Implications for Therapy

By Sandra Ríos-Arrabal, José Antonio Muñoz-Gámez, Sergio Manuel Jiménez-Ruíz, Jorge Casado-Ruíz, Francisco Artacho-Cordón and Josefa León-López


Open access peer-reviewed

3. Modulation of Apoptosis in Colon Cancer Cells by Bioactive Compounds

By Marinela Bostan, Mirela Mihaila, Camelia Hotnog, Coralia Bleotu, Gabriela Anton, Viviana Roman and Lorelei Irina Brasoveanu


Open access peer-reviewed

4. BRAF Mutation in Colorectal Cancer

By Louisa Lo, Timothy Price, Joanne Young and Amanda Townsend


Open access peer-reviewed

5. Colorectal Cancer Prevention and Risk Counseling

By Serife Koc, Melek Nihal Esin and Aysun Ardic


Open access peer-reviewed

6. Imaging of Colonic and Rectal Cancer

By Radu I Badea, Cosmin N Caraiani and Diana I Florian


Open access peer-reviewed

7. Endoscopic Submucosal Dissection for Early Colon Cancer

By Valentin Ignatov, Anton Tonev, Nikola Kolev, Aleksandar Zlatarov, Shteryu Shterev, Tanya Kirilova and Krasimir Ivanov


Open access peer-reviewed

8. Colorectal Cancer and Inflammatory Bowel Disease

By Paul Mitrut, Anca Oana Docea, Adina Maria Kamal, Radu Mitrut, Daniela Calina, Eliza Gofita, Vlad Padureanu, Corina Gruia and Liliana Streba


Open access peer-reviewed

9. Laparoscopy in the Management of Colon Cancer

By Valentin Ignatov, Anton Tonev, Nikola Kolev, Aleksandar Zlatarov, Shteryu Shterev, Dilyan Petrov, Tanya Kirilova and Krasimir Ivanov


Open access peer-reviewed

10. Current Immunotherapeutic Treatments in Colon Cancer

By Zodwa Dlamini, Thandeka Khoza, Rodney Hull, Mpho Choene and Zilungile Mkhize-Kwitshana


Open access peer-reviewed

11. The Management of the Primary Tumor in Patients with Metastatic Colorectal Cancer

By Shahid Ahmed, Selliah Kanthan, Nayyer Iqbal, Adnan Zaidi, Duc Le, Tahir Abbas and Kamal Haider


Open access peer-reviewed

12. Simultaneous Surgery for Synchronous Colorectal Liver Metastases

By Nikola Kolev, Valentin Ignatov, Anton Tonev, Aleksandar Zlatarov, Boryana Naydenova, Georgi Ivanov, Dilyan Petrov and Krasimir Ivanov


Open access peer-reviewed

13. Adjuvant Treatment in Colon Cancer

By Ivan Shterev Donev, Nikola Kolev, Valentin Ignatov, Anton Tonev, Aleksandar Zlatarov, Assia Konsoulova, Elitza Entcheva, Plamena Drenakova and Krasimir Ivanov


Open access peer-reviewed

14. Robot-Assisted Colonic Resections for Cancer

By Monica Ortenzi, Giovanni Lezoche, Roberto Ghiselli and Mario Guerrieri


Open access peer-reviewed

15. Immunotherapy in Colorectal Cancer

By Gabriel Mak, Michele Moschetta and Hendrik‐Tobias Arkenau


Open access peer-reviewed

16. New Chemotherapeutic Agents: Monoterpenes and Fatty Acid Synthase Inhibitors

By Soichiro Murata


Open access peer-reviewed

17. Anti-Epidermal Growth Factor Receptor (EGFR) Treatment in Patients with Metastatic Colorectal Cancer

By Rumeysa Ciftci and Deniz Tural


Open access peer-reviewed

18. Studies of Malaysian Plants in Prevention and Treatment of Colorectal Cancer

By Yumi Z. H-Y. Hashim, Chris I. R. Gill, Cheryl Latimer, Nigel Ternan and Phirdaous Abbas


Open access peer-reviewed

19. Adjuvant Systemic Therapy in Stage II and III Colon Cancer

By Fatma Sen and Kezban Nur Pilancı


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI
  • BKCI

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