Open access peer-reviewed Edited Volume

Etiology and Pathophysiology of Parkinson's Disease

This book about Parkinson's disease provides a detailed account of etiology and pathophysiology of Parkinson's disease, a complicated neurological condition. Environmental and genetic factors involved in the causation of Parkinson's disease have been discussed in detail. This book can be used by basic scientists as well as researchers. Neuroscience fellows and life science readers can also obtain sufficient information. Beside genetic factors, other pathophysiological aspects of Parkinson's disease have been discussed in detail. Up to date information about the changes in various neurotransmitters, inflammatory responses, oxidative pathways and biomarkers has been described at length. Each section has been written by one or more faculty members of well known academic institutions. Thus, this book brings forth both clinical and basic science aspects of Parkinson's disease.

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Etiology and Pathophysiology of Parkinson's DiseaseEdited by Abdul Qayyum Rana, Md, Frcpc, Frcp (hon)

Published: October 12th 2011

DOI: 10.5772/956

ISBN: 978-953-307-462-7

eBook (PDF) ISBN: 978-953-51-6523-1

Copyright year: 2011

Books open for chapter submissions

53482 Total Chapter Downloads

12 Crossref Citations

28 Web of Science Citations

37 Dimensions Citations


Open access peer-reviewed

1. Etiology and Pathogenesis of Parkinson’s Disease

By Taku Hatano and Nobutaka Hattori


Open access peer-reviewed

2. Genetics of Parkinson Disease

By Celeste Sassi


Open access peer-reviewed

3. Parkin and Parkinson’s Disease

By Shiam-Peng Tay, Grace G.Y. Lim, Calvin W.S. Yeo and Kah-Leong Lim


Open access peer-reviewed

4. Modeling LRRK2 Parkinsonism

By Kelly Hinkle and Heather Melrose


Open access peer-reviewed

5. Alpha-Synuclein Interactions with Membranes

By Katja Pirc and Nataša Poklar Ulrih


Open access peer-reviewed

6. Alpha-Synuclein, Oxidative Stress and Autophagy Failure: Dangerous Liaisons in Dopaminergic Neurodegeneration

By Giovanni Stefanoni, Gessica Sala, Lucio Tremolizzo, Laura Brighina and Carlo Ferrarese


Open access peer-reviewed

7. Targeting α-Synuclein-Related Synaptic Pathology: Novel Clues for Parkinson’s Disease Therapy

By Arianna Bellucci and PierFranco Spano


Open access peer-reviewed

8. Effects of Alpha-Synuclein on Cellular Homeostasis

By Kostas Vekrellis, Georgia Minakaki and Evangelia Emmanouilidou


Open access peer-reviewed

9. Actions of GDNF on Midbrain Dopaminergic Neurons: The Signaling Pathway

By Dianshuai Gao, Yi Liu, Shen Sun, Li Li and Ye Xiong


Open access peer-reviewed

10. The Hsp70 Chaperone System in Parkinson’s Disease

By Adahir Labrador-Garrido, Carlos W. Bertoncini and Cintia Roodveldt


Open access peer-reviewed

11. The Noradrenergic System is a Major Component in Parkinson’s Disease

By Patricia Szot, Allyn Franklin and Murray A. Raskind


Open access peer-reviewed

12. The Energy Crisis in Parkinson’s Disease: A Therapeutic Target

By Mhamad Abou-Hamdan, Emilie Cornille, Michel Khrestchatisky, Max de Reggi and Bouchra Gharib


Open access peer-reviewed

13. Analysis of Transcriptome Alterations in Parkinson’s Disease

By Elena Filatova, Maria Shadrina, Petr Slominsky and Svetlana Limborska


Open access peer-reviewed

14. Brain Mitochondrial Dysfunction and Complex I Syndrome in Parkinson ́s Disease

By Laura B. Valdez, Manuel J. Bandez, Ana Navarro and Alberto Boveris


Open access peer-reviewed

15. Role of Microglia in Inflammatory Process in Parkinson’s Disease

By Hirohide Sawada, Hiromi Suzuki, Kenji Ono, Kazuhiro Imamura, Toshiharu Nagatsu and Makoto Sawada


Open access peer-reviewed

16. Oxidative DNA Damage and the Level of Biothiols, and L-Dopa Therapy in Parkinson’s Disease

By Dorszewska Jolanta and Kozubski Wojciech


Open access peer-reviewed

17. Inflammatory Responses and Regulation in Parkinson’s Disease

By Lynda J. Peterson and Patrick M. Flood


Open access peer-reviewed

18. Mathematical Models: Interactions Between Serotonin and Dopamine in Parkinson’s Disease

By Janet Best, Grant Oakley, Michael Reed and H. Frederik Nijhout


Open access peer-reviewed

19. Dopaminergic Control of the Neurotransmitter Release in the Subthalamic Nucleus: Implications for Parkinson’s Disease Treatment Strategies

By Ben Ampe, Anissa El Arfani, Yvette Michotte and Sophie Sarre


Open access peer-reviewed

20. Possible Contribution of the Basal Ganglia Brainstem System to the Pathogenesis of Parkinson’s Disease

By Kaoru Takakusaki, Kazuhiro Obara and Toshikatsu Okumura


Open access peer-reviewed

21. Role of Lysosomal Enzymes in Parkinson’s Disease: Lesson from Gaucher’s Disease

By Tommaso Beccari, Chiara Balducci, Silvia Paciotti, Emanuele Persichetti, Davide Chiasserini, Anna Castrioto, Nicola Tambasco, Aroldo Rossi, Paolo Calabresi, Veronica Pagliardini, Bruno Bembi and Lucilla Parnetti


Open access peer-reviewed

22. Physiological and Biomechanical Analyses of Rigidity in Parkinson's Disease

By Ruiping Xia


Open access peer-reviewed

23. Mesothalamic Dopaminergic Activity: Implications in Sleep Alterations in Parkinson's Disease

By Daniele Q. M. Madureira


Open access peer-reviewed

24. Pathophysiology of Non-Dopaminergic Monoamine Systems in Parkinson's Disease: Implications for Mood Dysfunction

By Nirmal Bhide and Christopher Bishop


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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