Open access peer-reviewed Edited Volume


Cruz Vargas-De-León

Universidad Autónoma de Guerrero

Cruz Vargas-De-León received a certificate for highly cited research in "Mathematical Biosciences". He has been biographed by Marquis Who's Who in the World. Two of his articles have been awarded "Excellent papers" by National Program for Research Evaluation in Italy.


Generalized Estimating Equation Longitudinal Model Path Analysis Structural Equation Models Modelling Recurrent Events Multiple Survival Outcomes Spatial Models Temporal Models Meta-Regressions Clinical Trials Structural Equation Modelling Bayesian Statistics

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About the book

Statistics is one of the most applied branches of mathematics in science, and Statisticians have made advances in complex statistical methods. Some of the topics that have had development in medical statistics are models for diagnostic tests in the absence of a gold standard, novel network meta-analysis techniques for clinical trials or diagnostic tests, multicollinearity problems in regression models, and statistical methods for adaptive and sequential approaches in clinical trials.
The application of these complex statistical models provides a greater understanding of the complex processes and mechanisms. Complex statistical models are a powerful tool that enables researchers in the health and medical sciences to increase their knowledge and understanding of complex systems and thus advance knowledge.

This book is devoted to applying complex models to health and medical sciences, both the classical and Bayesian approaches, and this book contain documentation of the contributions with the codes or script of the data analysis, that is relevant because it will help readers apply the models to new contexts. 

Publishing process

Book initiated and editor appointed

Date completed: December 3rd 2021

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline Extended: Open for Submissions

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

Approved chapters written in full and submitted

Deadline for full chapters: March 1st 2022

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: May 20th 2022

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: July 19th 2022

All chapters are copy-checked and typesetted before being published. IntechOpen regularly submits its books to major databases for evaluation and coverage, including the Clarivate Analytics Book Citation Index in the Web of ScienceTM Core Collection. Other discipline-specific databases are also targeted, such as Web of Science's BIOSIS Previews.

About the editor

Cruz Vargas-De-León

Universidad Autónoma de Guerrero

Cruz Vargas-De-León is a Professor of Biostatistics and Applied Mathematics. He has a bachelor's degree in mathematics (Statistics), a master's degree in health sciences, a master's degree in complexity sciences, and is currently a Student Ph.D. in Health Sciences. He is interested in Biostatistical and Biomathematical Modelling for Health. He has published more than 50 scientific articles, 35 of them in high-impact journals and indexed in JCR. He is also an Academic Editor of “International Journal of Hypertension”. He has participated in the validation of surveys, randomized controlled trials, systematic reviews and meta-analyses, the construction of indices in medicine, and the identification of immunological biomarkers in cancer and epidemiological studies (Syphilis, Dengue, SARS-CoV-2, among others), and estimation of parameters of differential equation models. He has received a certificate for the highly cited research in "Mathematical Biosciences" (2016, Elsevier), and the Guerrero State Award for Merit in Science and Technology "Guillermo Soberón" (2016). He has been biographed by Marquis Who's Who in the World in Issue 30 (2013). Two of his articles have been awarded "Excellent papers" by National Program for Research Evaluation (2011-2014) in Italy. Since 2015 he is a member of the National System of Researchers (SNI, in Spanish) from the National Council of Science and Technology (CONACYT, in Spanish).

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Introducing your Author Service Manager

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As an Author Service Manager, my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact.

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