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Bieber",authors:[{id:"164758",title:"Associate Prof.",name:"Márcia",middleName:null,surname:"Silva Do Nascimento",fullName:"Márcia Silva Do Nascimento",slug:"marcia-silva-do-nascimento"}]}]}]},onlineFirst:{chapter:{type:"chapter",id:"66405",title:"Transcatheter Aortic Valve Replacement: Clinical Indications and Outcomes",doi:"10.5772/intechopen.84909",slug:"transcatheter-aortic-valve-replacement-clinical-indications-and-outcomes",body:'\nA population-based study done by Eveborn et al. demonstrated an increase in the prevalence of AS with age, from 0.2% at 50–59 years to 9.8% at 80–89 years [1].
\nPrevalence of any AS and severe AS from pooled data involving multiple studies was shown to be 12.5 and 3.4% respectively among people of age >75. Approximately half to one-third of patients with severe AS may be asymptomatic at the time of diagnosis [2].
\nDue to long asymptomatic period associated with severe Aortic stenosis, patients may not report any overt symptoms, or compensate for their decreased exertional capacity by slowing down their daily activities attributing it to normal aging. Addressing symptom onset in patients with severe AS is extremely important as the onset of symptoms markedly decreases survival unless aortic valve replacement is performed.
\nEarly observation done by Ross and Braunwald [3] showed that patients with angina have a 50% 5-year survival rate without AVR, those with syncope have 50% 3-year survival. Heart failure carries worse prognosis with mean survival rate of less than 2 years without AVR.
\nWhile SAVR is considered standard of care for management of symptomatic severe aortic stenosis, one-third of patients with severe AS with indications for SAVR may be denied surgery in view of advanced age and comorbidities.
\nCatheter-based balloon aortic valvuloplasty (BAV) was developed in 1985 as a less invasive solution for patients with symptomatic severe AS who were denied SAVR.
\nHigh rates of recurrence (80%) at 1 year associated with BAV hindered its widespread adaptability and search for other less invasive therapeutic option for severe AS patients was continued.
\nContemporary indications for BAV are listed in Table 1. Currently, BAV is reserved for use as a bridge-to-decision to provide more definitive therapy for AS and for patients with contraindications for TAVR in whom relief of Aortic obstruction will improve quality of life.
\nIndications for balloon aortic valvuloplasty (BAV).
To circumvent restenosis after BAV, a combination of stent frame and valve within was thought as an alternative. This arrangement could potentially implant an aortic valve in place of diseased native aortic valve using minimally invasive catheterization technique, thus avoiding high morbidity and mortality associated with high risk SAVR. Routine observation of high-pressure balloon inflation (4–5 atmospheres) leading to opening of all calcified aortic valves in a circular fashion led to the concept of TAVR [4].
\nIn 1992, Andersen and colleagues [5], used a hand-made porcine valve contained within a metallic mesh and successfully implanted at various cardiac sites in a pig model. This was the first evidence of use of a stented valve.
\nIn 1999 percutaneous valve technologies (PVT) designed early models of balloon expandable transcatheter heart valve (THV) [4].
\nThe first human implantation of a percutaneous stented valve to a degenerated right ventricle-to-pulmonary artery conduit was done in 2000 by Bonhoeffer and colleagues [6]. This was a bovine jugular valve mounted on stent platform.
\nAfter initial success with the sheep model, Dr. Alain Cribier and his team performed the first successful TAVR in human using a balloon expandable THV on 16th April 2002 as a bailout procedure after failed emergency BAV [4].
\nAfter initial success with the Sheep model, first human implantation with the balloon expandable Edwards valve was done on 16th April 2002 after failed emergency BAV as a bailout procedure [4].
\nAfter encouraging initial results, Dr. Cribier and team were able to recapitulate TAVR in a few patients. Worldwide demonstrations of this innovative therapy led to its increased acceptance. TAVR was transforming from a crazy idea to a viable therapy option. The Cribier valve technology was acquired by Edwards Lifesciences (Irvine, CA) for further development, and the THV was further marketed as Edwards Sapien valve.
\nSimultaneously scientists from Europe were working on a self-expandable valve (CoreValve, Medtronic, Inc.; Minneapolis, MN) platform as an alternative to balloon expandable valve since 2004 and human implantations were being done successfully.
\nAs the number of TAVR implantations increased, data from multiple small studies and registries like SOURCE, ADVANCE, FRANCE I and FRANCE II showed procedural success (30 days survival) ranging from 67–92%.
\nWith the available data, the European CE mark authorization was granted in August 2007 for the Edwards Sapien balloon expandable THV with the transfemoral RetroFlex delivery system and in January 2008 for use with the transapical Ascendra delivery device.
\nPARTNER was the first randomized trial that compared TAVR with standard therapy. Cohort B of this landmark trial demonstrated superiority of TAVR over medical therapy in patients with severe symptomatic AS who were considered extreme (or prohibitive) risk for SAVR. At 1 year follow up, absolute risk reduction in all-cause mortality of 20% was observed, a finding which held true even at 5 years follow up [7].
\nCohort A of PARTNER trial compared TAVR with SAVR and showed that TAVR was non-inferior to SAVR in patients with high surgical risk (society of thoracic surgeons (STS) score >8%). CoreValve extreme risk trial data showed benefit of TAVR with reduction in all-cause mortality.
\nIn November 2011, United States Food and Drug Administration (US FDA) approved TAVR as a treatment option for patients with symptomatic severe AS who were considered inoperable for SAVR. Favourable clinical data using self-expanding THV CoreValve (Medtronic) led to its USFDA approval in 2014 on similar patient subset.
\nWith the available evidence from randomised control trials (RCTs) and multiple registry data, TAVR was given Class I LOE B recommendation in patients with prohibitive (not suitable for SAVR) and increased surgical risk by ESC guidelines [8] and Class I LOE A by ACC/AHA guidelines [9].
\nAnother important observation noted in PARTNER 1 trial was diminishing survival benefit of TAVR with higher STS score. This led to stress more importance on patient selection.
\nIntermediate surgical risk (STS score ≥4–8%) patients with symptomatic severe AS were enrolled in PARTNER 2 trial comparing TAVR using second generation Sapien valve (Sapien XT) with SAVR along with subgroup analysis of transfemoral and transthoracic cohorts. All-cause mortality in TAVR arm was non-inferior to SAVR at 2 years with comparable stroke and permanent pacemaker rates.
\nThe SURTAVI (surgical replacement and transcatheter aortic valve implantation) trial used Self-expandable CoreValve and enrolled patients with symptomatic severe AS with intermediate surgical risk and showed all-cause mortality in TAVR group non-inferior to SAVR at 1 and 2 years.
\nPARTNER 2 and SURTAVI trials also showed a favourable decreasing trend in all-cause mortality and post-procedure stroke rates (refer to Table 2).
\nClinical trials data.
ACC/AHA has given Class II LOE (level of evidence) A recommendation for TAVR in intermediate-risk population [9].
\nWith the availability of 5-year data on TAVR showing good valve durability, focus of attention shifted to extend the benefit of TAVR to low-risk population with severe AS.
\nNOTION trial [10] and low-risk TAVR trial [11] evaluated the role of TAVR in low-risk population (STS score <4%).
\nNOTION trial is one of the earliest randomized trials, started recruiting patients in 2009 in a single centre. NOTION trial enrolled patients with symptomatic severe AS with low surgical risk and randomized them to TAVR versus SAVR. All-cause mortality at 1 year seen in this study was lower in TAVR arm compared to SAVR, an effect that persisted at 5 years.
\nThe post-procedure permanent pacemaker implantation (PPI) rates and PVL (paravalvular leak) were higher in the TAVR group. Despite higher PPI and PVL rates, the all-cause mortality was lower with TAVR than SAVR. Higher PPI rates were because of an overenthusiastic approach for pacemaker implantation in view of lack of experience during those days.
\nThe above-mentioned trials showed a consistent reduction in 30 days all-cause mortality attributed to improved technical advances, procedural skills and better patient selection (refer to Table 2).
\nA valve in valve (ViV), by virtue of the procedure being a re-do sternotomy, with patients typically in their 70 and 80s age, they usually fall into an intermediate risk category for surgical treatment. Most of the patients with degenerated bio prosthetic aortic valve qualify for TAVR.
\nThe main issues with ViV are under expansion of the valve leading to higher gradients and a higher risk of coronary obstruction.
\nBicuspid aortic valve (BiV), not approved, TAVR had been used off-label in BiV.
\nIssues related to the use of TAVR in BiV are:
\nLarge annulus with severe and asymmetric calcification or presence of raphe can hinder with positioning and expansion of the valve that can lead to PVL or annulus rupture.
\nIncreased risk of aortic dissection or rupture in view of concomitant aortopathy.
\nIn view of relatively young patients with longer life expectancy, the durability of TAVR valve is still a concern.
\nA study by Ravi et al., which included 435 patients with BiV, showed higher 30 days all-cause mortality with off label TAVR (8.5%) when compared with on label TAVR (6.1%) [12].
\nOutcomes are not as favourable as tricuspid valve, still a valid alternative in patients with higher surgical risk profile.
\nPatient evaluation is directed towards identifying patients where significant improvement in the quality and duration of life is expected with AVR and avoid unnecessary intervention where the benefit is unlikely due to other confounding co-morbidities.
\nExtreme comorbidities that overwhelm the benefit of TAVR may render the procedure futile as shown in PARTNER cohort B.
\nThe essential components for patient selection include:
Clinical risk stratification with emphasis on heart team
Geriatric risk stratification
Anticipated clinical benefit and
Assessment of patient’s goals and preferences
Anatomic assessment: MDCT as standard. 3D TEE as an alternative.
Accurate valve sizing
Vascular access planning
Important components of clinical risk stratification are mentioned in Table 3.
\nClinical predictors of increased risk.
STS-PROM and Euroscore II are the two most commonly used integrated risk scoring calculators used to assess surgical risk.
\nSTS risk scoring system had been extensively utilized in clinical decision making for TAVR. SAVR, components of which are showed in Table 4.
\nVariables included in STS PROM and variables not included in STS PROM.
STS score <4% is low risk.
\n≥4%, <8% is intermediate risk.
\n>8% is high risk.
\nConcept of heart team: doctors from various specialties as a team need to evaluate TAVR patients.
\nMultidisciplinary team approach provides an opportunity for active participation of doctors from multiple specialties and share views on different aspects of patient health care and also to counsel patient relatives on an anticipated line of management.
\nThe team should consist of referring physician, Clinical Cardiologist, Interventional cardiologist, cardiothoracic surgeon, Cardiac anaesthesiologist, dedicated cardiac imaging specialist, Valve clinic coordinator, dedicated nursing and catheterisation laboratory team.
\nBeyond the traditional co-morbidities like DM and HTN, the elderly population also need particular attention in terms of advanced frailty, disability in activities of daily living, malnutrition, mobility impairment, low muscle mass and strength, cognitive impairment and mood disorders.
\nThe commonly used assessment tools are shown in Table 5.
\nGeriatric assessment tools.
Trial evidence consistently shows, treatment with TAVR in patients with symptomatic severe AS results in reduction of all-cause mortality, improved duration of survival.
\nPatients symptomatic because of severe AS not because of other comorbidities have the greatest symptomatic benefit.
\nPatient pre-operative symptom status can be assessed by Kansas city cardiomyopathy questionnaire (KCCQ) [13] and can be followed up linearly.
\nThe assessment of futility must include consideration of patient’s values, goals, and preferences.
\nShared decision-making requires both patient and provider share information, work toward a consensus and reach agreement on the course of action.
\nIn the TAVR population, when benefit in symptom relief aligns with a patient’s goals, care may not futile.
\nHowever, when life prolongation and symptom relief is not anticipated, care may be futile.
\nTAVR is not recommended in patients with a life expectancy of <1 year, or if the benefit of TAVR will be less obvious in the backdrop of multiple co-morbidities.
\nAssessment of valve calcification, valve anatomy, annulus size, coronary height, an angle of implantation, size of sinuses of Valsalva, ascending aorta and peripheral vascular access by multidetector computerized tomography scan (MDCT) is an integral part of pre TVAR work up.
\nAnnulus is a virtual ring formed by basal hinge points of the valve cusps. The measurement of annulus size is a very important step as it determines the size of the TAVR valve.
\nProsthesis undersizing causes the risk of significant Paravalvular leak (PVL) or valve embolization, if oversized, disruption of the aortic root and cause annular rupture or impingement on conduction system and may cause bundle branch block or complete heart block.
\n3D TEE and MDCT are the two most commonly used imaging methods for annulus measurement.
\nMDCT is a non-invasive procedure, the ability to measure annulus during any part of the cardiac cycle and provide additional information like valve calcification, distribution of valve calcification, sizes of sinus of valsalva (SOV), coronary ostia distance from the annulus, makes it imaging of choice unless contraindicated in view of kidney injury [14].
\nMDCT because of excellent resolution provides a virtual roadmap for vasculature and allows identification of vessel size, tortuosity, calcification, and luminal diameter, which allows the planning of access routes with a view to minimizing vascular complication rate.
\nTAVR has seen an overall decline in peri-procedural complications over time, partly owing to newer technology and expertise.
\nComplications associated with TAVR are as listed in Table 6.
\nComplications of TAVR.
According to transcatheter valve therapy (TVT data), 30-day in-hospital mortality has decreased from 7.5% in 2012 to 4.6% in 2015 [15].
\nThis part of the chapter briefly reviews about important complications post TAVR.
\nAccess site complications incidence depends upon the method of localization and the location of the puncture site, the need for multiple punctures and the size of the sheath used. The incidence of major vascular complications showed a decreasing trend attributed to technical innovations reducing sheath size and valve delivery systems.
\nThe overall major vascular complication rate was 17% in PARTNER 1 trial, decreased to 2.5% in low-risk TAVR trial [11], 2018 due to improvements in the sheath and valve delivery systems.
\nNeed for PPI arises due to a complex interaction of the valve with the conduction system.
\nThe incidence of PPI has not decreased as expected, compared with other complications. Changes in the valve design to prevent PVL and position of valve implantation contributed for PPI.
\nPPI incidence appears to increase with the oversizing of the valve and changes in valve design to prevent PVL. Shallow implantation and improvement in technical skill could decrease the incidence of PVL as shown in the REPRISE trial.
\nPPI frequency varies in relation to the valve type used. Balloon Expandable valve has a relatively less incidence of PPI at the cost of higher valvular gradients.
\nThe incidence of new PPI post-TAVR was 6–10% in PARTNER 1 and PARTNER 2 trials which is similar to 5% seen in low-risk TAVR study [11].
\nThe requirement of PPI has been associated with increased hospital stay and financial burden but has not been shown to increase mortality conclusively.
\nPVL occurs because of the difference in the shape of the valve which is circular compared to the elliptical aortic annulus.
\nThe incidence of PVL is consistently shown to be higher with TAVR than SAVR in all landmark trials of TAVR.
\nValve size, aortic valve distribution of calcium and implantation depth were predictive of post TAVR PVL [16].
\nPrecise annulus sizing by appropriate aortic imaging pre-TAVR is fundamental to prevent PVL. With the use of newer imaging technology and understanding of the factors involved the incidence of moderate or severe PVL decreased 12.5% in PARTNER B to <1% in low-risk TAVR data [11]. Out of 12.5% moderate to severe PVL in PARTNER cohort B only 0.7% have severe leak, severe PVL causing an increase in mortality or need for re-intervention is very rare.
\nStroke is one of the most devastating complication post-TAVR, it causes an increase in mortality, significant worsening of quality of life and disability.
\nA stroke occurs due to the embolization of plaque contents from atheroma disrupted during delivery system manipulations. Early trial PARTNER 1 used a balloon-expandable valve with a 22-24F delivery catheter and showed a 30-day stroke risk of 5.5–6.2% [7].
\nThe risk of stroke decreased over the years with increasing operator experience, advancements in valve technology, and improvement in patient selection.
\nPARTNER 2 and CoreValve studies used Sapien XT and CoreValve which used 18F delivery catheter and showed a 30-day risk of stroke around 4% [17, 18, 19].
\nA study on the timing of stroke post-TAVR by Samir et al. showed that of strokes occurring within 30 days post-TAVR, 64% were diagnosed within 2 days and 85% were diagnosed within 1 week, the risk of stroke after the initial peri-procedural period is not high [20]. More balloon post dilations and lack of dual antiplatelet therapy before the procedure were associated with a higher risk of early stroke [20].
\nNewer advances like Sentinel cerebral protection system are recently approved by the US FDA and are commercially available.
\nThe Sentinel study investigated the role of Sentinel CPS (cerebral protection system) but failed to show a reduction in the median total new lesion volume on MRI. So In view of the lack of robust evidence regarding the efficacy of CPS, the choice of using neuroprotection in TAVR requires an individualized risk-benefit analysis.
\nInvestigations therapies like protecting aortic arch vessels with CPS, excluding the LAA and refining post procedural antithrombotic strategy may aid in a further reduction in stroke incidence.
\nStructural valve deterioration is defined as any change in valve function resulting from an intrinsic abnormality leading to an intervention.
\nIncrease in a mean gradient to >20 mm Hg or increase >10 mm Hg from baseline, an appearance of new valvular regurgitation constitutes SVD.
\nRising interest for the use of TAVR in low-risk population makes durability of valve an important concern where the life expectancy of the patients would be more than 15 years. Five-year data from PARTNER 1 trial showed stable valve area and mean transvalvular gradient throughout the follow-up. The mean valve area was 1.52 cm2 and the mean gradient was 10 mm Hg at 5 years and no events of clinical thrombosis of the TAVR valve [7].
\nAny increase in valvular gradients should warrant imaging workup for valve thrombosis. Data from multicentre registry showed, an incidence of VHD of 4.5% (overall VHD) and 2.8% within the first year (early VHD) [21].
\nMakkar et al. reported hypo-attenuated leaflet thickening (HALT) and reduced leaflet motion (RELM) in transcatheter valves, evaluated by four-dimensional volume-rendered computer tomography [22]. The effect of this finding on clinical outcomes needs further investigation.
\nWalksman et al. reported a 14% incidence of HALT and 11.2% RELM at 30 days post-TAVR, but were asymptomatic clinically.
\nMultivariate analysis showed the absence of anticoagulation at discharge, valve size <23 mm, a valve in valve procedure and greater BMI as predictors of transcatheter valve hemodynamic deterioration post-TAVR [21].
\nNon-existent with self-expandable valves except in cases where pre or post-dilation is performed.
\nBecause of the use of newer imaging modalities accurate sizing of the balloon, an annular rupture is a very rare phenomenon.
\nDevice embolization was defined as, Movement of valve prosthesis during or after deployment such that it loses contact with the aortic annulus. A study by Makkar et al., out of 2,554 patients who underwent TAVR, valve embolization was noted in 1% of patients. Technical factors like undersized valve and complex aortic valve anatomy, incomplete balloon inflation, and pacing failure were associated with valve embolization [23].
\nSymptomatic coronary obstruction following TAVR is rare but a life-threatening complication. Multicentre registry data shows an incidence of 0.6%. It was observed more frequently with balloon expandable valve and in those with a previous surgical prosthesis [24]. Low lying coronary ostium and shallow sinus of Valsalva were anatomical factors associated with the risk for coronary obstruction [24].
\nThe incidence of complications with TEE is <1%. Dental trauma, oral bleeding, oesophageal erosions and rarely oesophageal rupture.
\nRespiratory dependence, hypotension, nausea and vomiting are among common, complete description of anaesthesia related complications is beyond the scope of this chapter.
\nTAVR, a novel approach started as an impossible idea, witnessed a remarkable journey and now is an established therapy in management of symptomatic severe Aortic stenosis patients. Outcomes post TAVR are bound to get better as technology improves and expertise increases. “TAVR first approach may be the future.”
\nCARE Hospitals, Banjara Hills, Hyderabad.
\nThere are no conflicts of interest.
\n aortic stenosis society of thoracic surgeons, predicted risk of mortality myocardial infarction ventricular tachycardia/ventricular fibrillation cardiothoracic surgeon permanent pacemaker implantation paravalvular leak valve academic research consortium cerebral protection system left atrial appendage valve hemodynamic deterioration structural valve degeneration transcatheter aortic valve replacement hypo attenuated leaflet thickening reduced leaflet motion chronic obstructive pulmonary disease coronary artery bypass graft balloon aortic valvuloplasty transcutaneous heart valve percutaneous valve technologies placement of aortic transcatheter valve trial Sapien aortic bioprosthesis European Outcome Registry Nordic aortic valve intervention trial surgical replacement and transcatheter aortic valve implantation sinus of valsalva transcatheter valve therapy trans oesophageal echo
IntechOpen publishes different types of publications
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