Arpad Dobolyi

Semmelweis UniversityHungary

Appointments and education: 2007- Department of Anatomy, Histology and Embryology, Semmelweis University, Research Associate Professor 2005-2007: Hungarian Academy of Sciences – Semmelweis University Neuromorphological and Neuroendocrine Research Laboratory, Budapest, Hungary, Senior Investigator 2001-2005: Laboratory of Genetics, National Institute of Mental Health, NIH, Bethesda, USA, Research Fellow 1999-2001: Research Group of Neurobiology, Hungarian Academy of Sciences – Eötvös University, Research Associate 2000: PhD in Medicine, summa cum laude 1995-1998: Semmelweis University Doctoral School, Cellular and Molecular Physiology Program 1993-1994: University of Bristol, Bristol, UK; Pharmacology 1990-1995: Eötvös University, Budapest, Hungary; Chemistry Grant support: 1. 2009-2011 NFM-OTKA NNF 78219 Research Grant of the Hungarian Scientific Research Fund. Title: Transforming growth factor beta proteins in the central nervous system. 2. 2007-2011 NKTH-OTKA K67646 Research Grant of the Hungarian Scientific Research Fund. Title: Morphological basis of the role of a novel peptidergic neuromodulator system in nociceptive information processing. 3. 2005-2007 MC-IRG 016423 Marie Curie International Reintegration Grant of the European Commission. Title: Expression and neuroprotective function of latent transforming growth factor beta binding proteins in the central nervous system of rodent and human. 4. 2004-2005 NARSAD Young Investigator Award Grant. Title: The action of TIP39 on corticotropin-driven stress systems. 5. 2009-2013 NKTH TECH_09_A1 Grant of the National Office for Research and Technology (Hungary). Title: Development of intelligent nanosensor diagnosing ion homeostasis at subcellular level. 6. 2008-2011 OTKA NK 72929 Research Grant of the Hungarian Scientific Research Fund. Title: Topography and neurochemical characterization of hypothalamic and central autonomic pathways. Honors and awards: 2007: Bolyai János Fellowship Award of the Hungarian Academy of Sciences 2005: Marie Curie Intra-European Fellowship Award of the European Commission, Brussels, EU 2004: Young Investigator Award of NARSAD (National Alliance for Research on Schizophrenia and Depression). 2004: FARE Award (Fellows Award for Research Excellence) at the National Institutes of Health, an award for winners of the annual competition of fellows’ scientific presentations SELECTED PUBLICATIONS (23 out of 46 research articles; total impact factor: 150.893) 1. Dobolyi A. (2011) Novel potential regulators of maternal adaptations during lactation: tuberoinfundibular peptide 39 and amylin. J. Neuroendocrinol. 2011 Mar 21. doi: 10.1111/j.1365-2826.2011.02127.x. [Epub ahead of print], PMID: 21418340. 2. Dobolyi A., Kovács Z., Juhasz G., Kardos J. (2011) Uridine function in the central nervous system. Curr. Top. Med. Chem. 2011 Mar 14. [Epub ahead of print], PMID: 21401495. 3. Cservenák M., Bodnár I., Usdin T.B., Palkovits M., Nagy G.M., Dobolyi A. (2010) Tuberoinfundibular peptide of 39 residues is activated during lactation and participates in the suckling-induced prolactin release. Endocrinology, 151, 5830-5840. 4. Palkovits M., Usdin T.B., Makara G.B., Dobolyi A. (2010) Tuberoinfundibular peptide of 39 residues-immunoreactive fibers in the zona incerta and the supraoptic decussations terminate in the neuroendocrine hypothalamus. Neurochem. Res. 35, 2078-2085. 5. Vincze C., Pál G., Wappler E.A., Szabó É.R., Nagy Z., Lovas G., Dobolyi A. (2010) Transforming growth factor beta isoforms in the intact rat brain and following experimentally induced focal ischemia. J. Comp. Neurol. 518, 3752-3770. 6. Dobolyi A., Palkovits M., Usdin T.B. (2010) The TIP39-PTH2 receptor system: unique peptidergic cell groups in the brainstem and their interactions with central regulatory mechanisms. Prog. Neurobiol. 90, 29-59. 7. Dobolyi A (2009) Central amylin expression and its induction in rat dams. J. Neurochem. 111, 1490-1500. 8. Bagó A.G., Dimitrov E., Saunders R., Seress L., Palkovits M., Usdin T.B., Dobolyi A. (2009) Parathyroid hormone 2 receptor and its endogenous ligand TIP39 are concentrated in endocrine, viscerosensory and auditory brain regions in macaque and human. Neuroscience. 162, 128-147. 9. Varga T., Palkovits M., Usdin, T.B., Dobolyi A. (2008) The medial paralemniscal nucleus and its afferent neuronal connections in rat. J. Comp. Neurol. 511, 221-237. 10. Brenner D., Bagó A.G., Gallatz K., Palkovits M., Usdin T.B., Dobolyi A. (2008) Tuberoinfundibular peptide of 39 residues in the embryonic and early postnatal rat brain. J. Chem. Neuranat. 36, 59-68. 11. Dobolyi A., Palkovits M. (2008) Expression of latent transforming growth factor beta binding proteins in the rat brain. J. Comp. Neurol. 507, 1393-1408. 12. Wang J., Palkovits M., Usdin T.B., Dobolyi A. (2006) Forebrain projections of TIP39-containing subparafascicular neurons. Neuroscience 138, 1245-1263. 13. Wang J., Palkovits M., Usdin T.B., Dobolyi A. (2006) Afferent connections of the subparafascicular area in rat. Neuroscience 138, 197-220. 14. Dobolyi A., Wang J., Irwin S., Usdin T.B (2006) Postnatal development and gender-dependent expression of TIP39 in the rat brain. J. Comp. Neurol. 498, 375-389. 15. Dobolyi A., Irwin S., Wang J., Usdin T.B. (2006) The distribution and neurochemistry of the parathyroid hormone 2 receptor in the rat hypothalamus. Neurochem. Res. 31, 227-236. 16. Dobolyi A., Irwin S., Makara G., Usdin T.B., Palkovits M. (2005) Calcitonin gene-related peptide-containing pathways in the rat forebrain. J. Comp. Neurol. 489, 92-119. 17. Dobolyi A., Palkovits M., Bodnar I., Usdin T.B. (2003) Neurons containing tuberoinfundibular peptide of 39 residues project to limbic, endocrine, auditory and spinal areas in the rat. Neuroscience 122, 1093-1105. 18. Dobolyi A., Palkovits M., Usdin T.B. (2003) Expression and distribution of tuberoinfundibular peptide of 39 residues in the rat central nervous system. J. Comp. Neurol. 455, 547-566. 19. Dobolyi A., Ueda H., Uchida H., Palkovits M., Usdin T.B. (2002) Anatomical and physiological evidence for involvement of tuberoinfundibular peptide of 39 residues in nociception. Proc. Natl. Acad. Sci. U. S. A. 99, 1651-1656. 20. Dobolyi A., Reichart A., Szikra T., Nyitrai G., Kékesi A.K., Juhász G. (2000) Sustained depolarisation induces changes in the extracellular concentrations of purine and pyrimidine nucleosides in the rat thalamus. Neurochem. Int. 37, 71-79. 21. Dobolyi A., Szikra T, Kékesi A.K., Kovács Zs., Juhász G. (1999) Uridine is released by depolarization and inhibits unit activity in the rat hippocampus. NeuroReport 10, 3049-3053. 22. Dobolyi A., Reichart A., Szikra T., Juhász G. (1998) Purine and pyrimidine nucleoside content of the neuronal extracellular space in rat. An in vivo microdialysis study. Adv. Exp. Med. Biol. 431, 83-87. 23. Dobolyi A., Reichart A., Szikra T., Szilágyi N., Kékesi A.K., Karancsi T., Slégel P., Palkovits M., Juhász G. (1998) Analysis of purine and pyrimidine bases, nucleosides and deoxynucleosides in brain microsamples (microdialysates and micropunches) and cerebrospinal fluid. Neurochem. Int. 32, 247-265.

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