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1. Introduction
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Resource depletion and carbon emissions caused by using fossil fuels have increased interest in alternative fuel sources. Utilization of biomass resources is one option to meet the energy requirements for rapid industrialization and population growth with potential environmental and economic benefits. Energy could be derived from a variety of terrestrial, renewable, bio-based feedstocks like sugar-based biomass (e.g. corn, sugarcane, sugarbeet) and lignocellulosic biomass (e.g. wheat straw, corn stover, sugarcane bagasse, forestry residues, switchgrass, energy cane, sorghum, short rotation woody crops). However, production and conversion of these feedstocks could entail risks associated with disruption of the food chain and biodiversity, depletion of freshwater resources and eutrophication.
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Aquatic biomass like microalgae is a promising feedstock with many advantages over terrestrial plants. Its use dates to 1940s [1, 2]. To meet an energy shortage during this period, microalgal biomass was proposed to be used as a source for lipids. Microalgae have higher yield from incident solar energy and higher areal productivity. The photosynthetic efficiency of microalgae (around 3–8%) is substantially higher than that of terrestrial plants (typically 0.5%) due to their simple structure and convenient access to nutrients [3, 4, 5, 108]. Therefore, less land area is required and non-arable, non-productive land could be used for their cultivation. Some species could be cultivated using low quality water such as seawater, brackish water, desalination reject water and wastewater. A microalgae production facility could be operated as a closed loop system by allowing for recycling of water, nutrients and energy from downstream production processes [6, 7, 144]. Microalgae are characterized by high lipid/starch/protein content with a lack of lignin, which makes them well-suited for different conversion technologies [8, 9, 10]. Besides, microalgae cultivation has less potential to interfere with food and feed production. With such versatility, microalgae appear to be a promising biorenewable resource that has the potential to completely replace fossil resources [11]. Research in microalgae biotechnology has increased dramatically since 2005 and has been a very active field in recent years, especially to produce biomass and biofuels [12, 110, 111, 117, 118, 136, 143].
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Though microalgae may demonstrate benefits over terrestrial feedstocks, the major challenges for their production include significant utilization of nutrients, high energy input for harvesting and dewatering, and complex downstream conversion processes for usable fuels like ethanol and biodiesel [6, 8, 100, 109, 131]. An alternative which can potentially decrease the energy footprint could be biogas production through anaerobic digestion [122, 125, 127, 137]. Anaerobic digestion (AD) is a biochemical process that mineralizes organic compounds to biogas through the synergistic and concerted action of microorganisms under anaerobic (O2 free) conditions. Dry biogas is primarily a mixture of methane and carbon dioxide with traces of ammonia, volatile organic compounds and hydrogen sulfide. Methane content of dry biogas usually ranges between 50 and 70% (by volume). Methane has a higher heating value on a mass basis when compared to liquid fuels, such as biodiesel and bioethanol [13, 145]. AD has been recognized as a mature technology to treat organic waste streams and is widely practiced due to its high energy output to input ratio, environmental benefits, as well as for its process simplicity—compared to bioethanol/biodiesel processes [13, 14]. It is suitable for organic feedstock with high moisture content [15] and so can directly be applied to wet algae biomass feedstock with perhaps little dewatering. Besides, no harsh pretreatment is necessary for algal biomass due to the negligible lignin content [14]. The algal biorefinery could be engineered to be resource efficient by recycling phosphorus and nitrogen nutrients in the digestate effluent and carbon dioxide from biogas upgrading processes for microalgae cultivation [13, 14, 16, 17].
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In addition to the physical and chemical properties of the fuel as specified by technical standards, the characteristics desired by the stakeholders, distributors and, consumers could also include sustainability indices related to environmental, social and economic performance. Techno-economic analysis (TEA) establishes a capital and operating cost profile to determine the potential economic viability of the production process for realizing its commercial feasibility. It can be an integral tool to direct research during development of specific technology and assist with investment by averting unnecessary expenditures. A number of techno-economic assessments have been completed to evaluate the economic feasibility of biodiesel derived from microalgae [9, 22, 69, 140, 141]. However, there is a lack of techno-economic analysis on anaerobic digestion of microalgae for biogas production, especially full-scale production taking the characteristics of algae species into consideration. In this chapter, the entire production process from algae cultivation to biogas upgrading will be discussed emphasizing the key cost drivers. TEA literature is reviewed for methodology and state of art technologies. An example of TEA was conducted based on the biogas production process from a microalgae/cyanobacteria species Cyanothece BG0011 [82].
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2. Anaerobic digestion
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An anaerobic digestion (AD) process can biochemically convert the whole, wet biomass rather than specific components. The emissions and effluents from the process can be captured for reuse of components like carbon dioxide, ammonia, and phosphorus, and therefore has the potential for economic and environmental benefits. The general biochemical steps in the AD process include: (1) hydrolysis: the breakdown of macromolecules like proteins, lipids, polysaccharides into simpler compounds such as amino acids, sugars, fatty acids and glycerol; (2) acidogenesis and acetogenesis: the hydrolyzed molecules are converted to volatile fatty acids, primarily acetate, hydrogen, and carbon dioxide; (3) methanogenesis: methane production from acetate, hydrogen and carbon dioxide. The hydrolysis step plays a crucial role in determining the successful production of methane [37, 145]. The biochemical processes in AD also occur in nature. AD technology is well established and recognized as a robust technology to convert biomass to bioenergy [146].
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Despite the potential, questions related to the economic feasibility and the net energy output are the main hurdles hampering the development of biogas production from microalgae [14, 18, 19, 20]. For example, due to the specific structure and composition of the microalgae cell wall, the yield of biogas could be low. Pretreatment to disrupt the cell walls could require high energy inputs. The algae productivity could be low and cultivation cost could be high. Thus, the viability of microalgal biogas production may depend on improvements of efficiency and economic performance. Ongoing efforts include developing inexpensive biomass feedstock, maximizing energy return on investment, and minimizing environmental risks. As only a few studies are available in the literature on the economic feasibility of microalgal biogas exploitation [14], the evaluation and analysis of microalgal biogas production cost will be based on conversion efficiency, technological design aspects as well as available cost information.
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3. Key drivers of microalgal biogas production cost
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The production of biogas from microalgae feedstock entails a series of steps starting with algae cultivation. Implementation of each step involves capital and operational expenditures. The key drivers such as algal biomass productivities, harvesting and dewatering techniques, AD designs, biogas utilization options, integration of algal production, and AD with other bioprocesses were addressed. The production cost breakdown was illustrated in a harmonized framework and a dynamic connection between the technological and economic/environmental assessments was established.
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3.1. Microalgae cultivation, harvesting and dewatering
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A photobioreactor is the essential component of an algae cultivation facility. An open raceway pond (ORP) and a closed photobioreactor (PBR) are two major cultivation platforms. These two platforms for algae biomass production have been extensively studied [22, 23, 24, 25, 26, 27, 83, 84, 85, 101]. The main differences are highlighted in Table 1. In addition, the steps from inoculum preparation to obtaining the wet algal paste typically include systems for culture circulation, growth medium supply, air/flue gas supply, culture cooling, culture harvesting, and process monitoring. Heat exchangers, pumps, and a piping network are also required. The location and climate are important factors for algae cultivation.
A comparison of the open raceway and closed bioreactor systems for algae cultivation.
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Due to the high methodological variation of TEA in literature, drawing a generic conclusion over the economic feasibility of microalgal cultivation could be impossible. From the technological and economic perspective, the factors presented below are the ones most prominent in the existing literature and identified as important topics in the development of algae fuels.
Microalgae productivity and culture stability. According to Davis et al. [23], achievable productivity has a strong influence on the economics. Productivity of more than 25 g/m2/day annual average is critical for maintaining a relatively low minimum biomass selling price. A significant increase in productivity has to be achieved to reduce cost substantially [25]. The cultured strain should have high growth rate and a steady biomass composition. GMOs or extremophiles could provide culture robustness [22]. However, due to lack of regulations for managing GMOs, it is unlikely permits could be obtained for commercial cultivation of GMO algae strains. For commercial outdoor systems, uncertainties could be associated with seasons of the year and across multiple locations. Thus, the productivity data should be integrated with meteorological data for geographically and seasonally resolved assessments using a robust strain.
Photobioreactor design, construction, and operating conditions. For the open pond system, pond liners were found to be one of the primary cost contributors [22, 23, 28]. The location of the pond facilities could be selected according to the nature of the soil. For example, ponds built on soil with high native clay content could avoid full liners to reduce the cost. Acién et al. [26] presented a cost analysis of microalgae production using tubular photobioreactors. In these systems, photobioreactors were found to be one of the significant cost contributors. Generally, open raceway ponds are economically advantageous by more than a factor of 2, compared to closed photobioreactors [29]. However, due to increased productivity and culture stability, closed photobioreactors still have the potential for commercial applications.
Energy consumption. Primary energy consumption is due to the energy required for mixing, circulation, aeration and CO2 sparging. The energy consumption for mixing at experimental scales usually exceeded commercial-scale operations requirements and needs to be optimized to determine the minimum energy requirement [27, 28]. Mixing devices such as the paddle wheels are significant capital cost contributors besides the photobioreactors.
Nutrients and carbon dioxide supply. Higher productivity usually involves higher consumption of nutrients. Thus, nutrient input needs to be adjusted to balance the tradeoff against productivity [23]. Carbon dioxide was found to be the most expensive consumable among the raw materials [26]. Siting algae cultivation facilities on land adjacent to industrial CO2 sources like flue gases may be effective in reducing cost. However, the substantial logistical and practical constraints of using flue gases in facilities of varying sizes are still a challenge [23].
Land and water. Even though, microalgae can be cultivated on nonarable land, the soil composition, climate, solar radiation have a substantial influence on their growth. The most suitable location should be warm places or close to the equator where insolation is not less than 3000 h/year [24]. Water is required during algae cultivation to compensate for evaporation or for cooling purposes. Availability of water at low cost is critical for process success. Water reuse, wastewater, seawater, brackish water and reasonable distance to the water source has the potential to reduce costs.
Scaling. It is critical to quantify the economy of scale for algae production to achieve economic viability [23]. However, large uncertainties and unrealistic assumptions will exist in the research where the productivity potential for microalgae at large-scale is being estimated through linear extrapolation for laboratory-based growth data [30]. Data variability and growth modeling considering geographical information should be considered in large-scale assessments.
Labor and depreciation. Tredici et al. [21] performed a TEA of the microalga Tetraselmis suecica production based on a 1-ha plant in Tuscany, Italy. Cost data were collected from manufacturers and suppliers as well as operating data from pilot and commercial facilities. This study found that the major fraction of cost was labor at small scales (1 ha) and when the pilot plant is scaled to 100 ha, capital expenses contribute the most to the production cost. This assessment is site and strain-specific, but still provides valuable insights for the economic evaluation.
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Algae harvesting and dewatering methods include gravity settling, chemical coagulation, flocculation, filtration, centrifuge, and drying. The economic feasibility and energy consumption are two criteria for assessing the performance of unit operations for harvesting and dewatering methods. It was found that the cost of separation takes 20–30% of the biomass production costs [32, 33]. Gravity settling, chemical coagulation, and flocculation usually concentrate the microalgal slurries to 2–7% while filtration and centrifugation concentrate microalgal slurry to 15–25% of total suspended solids [32]. The suitability of microalgal dewatering methods has been investigated for scalability, species flexibility, and downstream processing efficacy [33, 34, 35, 36]. Dewatering methods reaching high biomass concentrations are usually associated with high energy input and cost. Thus, a combination of dewatering methods such as flocculation followed by filtration is generally considered to be economical due to the increased harvest efficiency. For downstream processing, methods such as flocculation using flocculants comprised of cationic and anionic poly-electrolytes, synthetic polyacrylamide polymers and starch-based polymers can be employed. However, the detrimental effect of these flocculants on the subsequent microbial processes need to be considered. For example, anaerobic digester stability and gas production could be affected by metal contamination. Future work should include replacing chemical coagulants with natural and low-cost organic ones for harvesting algal biomass.
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3.2. Anaerobic digestion systems
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3.2.1. Pretreatment
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The efficiency of biogas production has been shown to be species-dependent [39]. One crucial factor is the differences in structure of microalgae cell walls. The role of the cell wall in the microbial degradability of algae biomass is highlighted in many investigations [6, 13, 37, 38, 40, 41, 42, 43]. Many microalgae species (e.g. Chlorella kessleri, Scenedesmus) have recalcitrant cell walls, which make it difficult for anaerobic cultures to hydrolyze microalgal intracellular organic matter. Thus, to improve the biodegradability of microalgal biomass, pretreatments methods have been developed to disrupt or solubilize cell walls [112, 113, 114, 115, 116]. General insights from these studies are: (1) pretreatment methods are species-specific and their success depends on the nature of the cell wall; (2) mechanical pretreatments which consume electricity are more energy intensive than thermal, chemical and enzyme pretreatments; (3) chemical pretreatments usually have a low cost but produce inhibitory substances which could hamper the AD process; (4) for pretreatment mechanisms such as disruption of microalgal cell walls, the synergistic effects of the enzymes need further investigation; (5) combined pretreatments may provide energy and cost-effective options; (6) multi-objective optimization techniques could be used to obtain a high biogas yield with a positive energy balance; (7) enzyme/biological pretreatments have high selectivity, low inhibitory effects and higher probability of positive energy return [147]; (8) research on pilot/demonstration scale pretreatments is rare; (9) thermal pretreatments have been employed widely and proven to be the most efficient in microalgae pretreatment for AD; and (10) a detailed economic/energy analysis of microalgal AD for biogas production with pretreatment is still missing.
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3.2.2. Hydraulic retention time (HRT), organic loading rate (OLR), and reactor configurations
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The capital cost of the anaerobic digester could be reduced by using reactors designed for high OLR and low HRT [37]. The OLRs are typically between 1 and 6 g VS/L/d while the HRT varies between 10 and 30 days [37, 38]. Although high OLR will increase the methane productivity, overloading will decrease the biogas production efficiency due to the accumulation of inhibitors such as ammonia and acids [6, 37, 38]. Also, prolonged HRT could lead to ammonia inhibition due to slow liquid removal rate [41], while a low HRT could cause the washout of the anaerobic bacteria community [6]. Thus, an optimized OLR and HRT should be applied to achieve the expected specific methane yield. Possible solutions could be improving anaerobic digester configurations such as using membrane reactors or upflow anaerobic sludge blanket reactors to decouple the OLR and HRT [37, 119] and on-line control of anaerobic digester operation [124]. These have not been applied for digesting algal biomass. Additional costs for land and infrastructure and energy expenditures for heating the digesters should be included in the economic analysis.
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3.2.3. Temperature, pH, salinity, sulfur, and lipids content
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AD microorganisms can grow in three temperature regimes: (1) psychrophilic (5–20°C); (2) mesophilic (25–45°C); and (3) thermophilic (45–65°C). The temperature effect on AD has been discussed [13, 37, 41]. The beneficial temperature regime for AD operation is anaerobic digester is species-specific [44, 45]. The rate of methane generation can be enhanced under mesophilic and thermophilic conditions. The increased temperature could improve enzymatic activity for degrading microorganisms, and at the same time, the photosynthesis activity of viable microalgae within the digester could be reduced [13, 37]. However, an increase in temperature beyond the tolerable range of each temperature regime could cause inactivation of the microbes. Thermophilic temperature may cause increased hydrolysis of nitrogenous compounds which may increase ammonia levels and in turn can cause inhibition [6]. For large-scale biogas productions, the energy required for heating may be more than 1/3 of the total energy output in the form of biogas [46]. Thus, the net energy production from algae biogas may still be limited due to the high heat input associated with a low concentration of algae substrates.
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The pH needs to be maintained at an appropriate level for efficient conversion of biomass to biogas. The growth of microbes, enzyme activity, and the biogas compositions are influenced by the pH [47]. The optimum pH level depends on each step of AD [41]. Generally, the pH values are maintained between 7 and 8 for single stage anaerobic digesters [13, 41].
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Microalgae grown in a saline environment offer a sustainable alternative to other biomass by utilizing non-arable land and seawater. Marine microalgae can usually grow in a salinity range of 35–125 ppt [48]. However, when a highly saline culture is processed in an anaerobic digester, the high salinity could be inhibitory to the AD process. The effects of salinity and concentration of sodium are discussed in previous studies [6, 38]. Adaptation of anaerobic digester microbial consortiums under different saline conditions was investigated by Mottet et al. [121]. In a promising study, methane production was observed from anaerobically digesting Dunaliella salina biomass at 35 g/L of salinity.
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Sulfide is a required micronutrient for anaerobic microorganisms, but high concentrations of sulfide (200 mg/L) could be toxic [6]. For saline microalgal species, the sulfur inhibition may occur due to the presence of oxidized sulfur compounds in saline algae growth medium. Proper inoculum selection for anaerobic digesters could favor the growth of methanogenic bacteria and limit the growth sulfate-reducing bacteria [49].
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Lipids can also be inhibitory to the AD process [6, 18, 50] although lipids have a high theoretical methane potential. Generally, inhibition would occur when lipids concentrations are higher than 30%. In this case, the high-lipid microalgae are suitable for lipid extraction for production of liquid fuels.
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3.2.4. C/N ratio
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Microalgae biomass generally has a higher composition of protein than terrestrial plants [6, 37]. The degradation of protein will cause ammonia accumulation and inhibit the methanogenesis process. The optimum C/N ratio for AD is between 15 and 30 while this C/N ratio for microalgal AD is generally below 10 [13, 38, 41]. Thus, increasing C/N ratio and reducing the ammonia toxicity are important to enhance the biogas yield and productivity from microalgae. Possible solutions to this issue could be; (1) using ammonia-tolerant inoculum generated either by bioaugmentation or by acclimation [37, 38]; (2) using microalgae biomass that was cultivated under nitrogen-limitation [41, 99, 102, 130]; (3) co-digestion with sludge, oil-greases, waste paper and food wastes [13, 41, 54]; and (4) using a two-stage AD for better control of the anaerobic microbial communities [6]. However, these solutions may add more complexity to the system, in which the economic and energetic performance is still clear. For example, the co-substrate needs to be secured for co-digestion; the digester volume and cost may increase due to the loading of the co-substrate; more environmental burdens may be associated with the shipping of biomass, and nitrogen-limitation cultivation may affect microalgae productivity.
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3.2.5. Other factors
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Many other factors could affect the biogas yield and production of microalgal biomass. For example, the harvesting time influences the composition and biodegradability of algal biomass. Thus, it is essential to harvest algae in the appropriate stage of growth [13]. Storage conditions such as temperature also have an impact on biomass quality like macromolecular distribution and the content of organic compounds. Besides, inoculum to substrate ratio control is instrumental in avoiding inhibition problems such as drop in pH [51].
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3.2.6. Biochemical methane potential (BMP) of microalgae biomass
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The overall biogas yields depend on the chemical composition of the algae strains. The target strain should be highly digestible. The volatile solids/ash-free dry weight of microalgae plays a significant role in predicting theoretical biogas production potential, which is a critical factor in determining biogas productivities. Theoretically, the methane yield from different components of microalgae is as follows: lipids—1 L CH4/g VS, proteins—0.85 L CH4/g VS, carbohydrates—0.42 L CH4/g VS at standard conditions. Although the lipids have a high theoretical methane yield in AD, a high lipid content (more than 40%) will produce inhibitory substances such as long chain fatty acids [6]. Thus, for high-lipid content microalgae, lipid removal for biofuels production may be a better solution than biomass sent directly to AD.
\n
The impact of the algae cell wall is another critical factor affecting methane yield. Some species either lack cell wall or have cell walls rich in easily-biodegradable proteins as in Dunaliella salina, a halophilic microalgae and Chlamydomonas reinhardtii, a fresh water green microalgae [38]. Even easily degradable cell wall alone does not ensure efficient methanization. Factors such as the presence of methanogenesis inhibitors, anaerobic microbial community, hydraulic retention time, organic loading rates, salinity, carbon to nitrogen ratio, and the concentration of digestible substrate will also affect the final methane yield of microalgae.
\n
The microalgal strains which have been investigated extensively include Scenedesmus, Chlamydomonas, Chlorella, and Nannochloropsis [12]. The compositions of these four species are shown in Table 2. AD conversion process with biochemical methane potential (BMP) to theoretical methane potential (TMP) ratio ≥ 70% are considered highly efficient. Chlamydomonas reinhardtii could achieve a 74% BMP (405 ml methane/g VS) to TMP (549 ml methane/g VS) ratio without any pretreatment [52]. Schwede et al. [53] achieved high digestibility of Nannochloropsis salina with thermal pretreatment. The methane yield significantly increased from 0.2 to 0.57 m3 kg VS−1 under batch conditions with a BMP to TMP ratio increasing from 31 to 89%. Similarly, Chlorella vulgaris shows a significant increase in BMP after pretreatments: from 54 to 85% BMP/TMP ratio [41, 52] under an enzyme pretreatment; and from 62 to 78% BMP/TMP ratio under a biological pretreatment [55, 123]. Scenedesmus sp. did not show a BMP/TMP ratio higher than 60%, even after enzyme or thermal pretreatments [56, 57]. The BMP varies from species to species, but no significant difference was found between fresh water microalgae and saline microalgae [58].
\n
\n
\n
\n
\n
\n
\n\n
\n
Components
\n
Species
\n
\n
\n
Scenedesmus sp.
\n
Chlamydomonas reinhardtii
\n
Chlorella vulgaris
\n
Nannochloropsis salina
\n
\n\n\n
\n
Protein % of DW
\n
33
\n
65
\n
64
\n
19
\n
\n
\n
Carbohydrates % of DW
\n
35
\n
23
\n
18
\n
45
\n
\n
\n
Lipids % of DW
\n
22
\n
13
\n
10
\n
36
\n
\n\n
Table 2.
Approximate compositions of four microalgal species: Scenedesmus sp., Chlamydomonas reinhardtii, Chlorella vulgaris, and Nannochloropsis salina [41].
\n
\n
\n
\n
\n
4. Techno-economic analysis
\n
In published TEA works, the process complexity was often simplified in terms of limited pathways, few choices of economic drivers and implicit assumptions regarding the growth conditions, process modeling factors and financing of the production facility. Existing reviews in anaerobic digestion of microalgae biomass such as Ward et al. [6] focus on the integration of anaerobic digestion into biodiesel refineries. Considering that diesel or ethanol are more valuable products, anaerobic digestion was suggested to treat the residual biomass to improve the economic viability and sustainability of overall microalgae biodiesel/ethanol stages. Global research in various pathways is going on towards the sustainable development of algae biofuels. The following sections will review these works, highlight the variability of methods of estimating microalgal biogas production cost, find the key drivers of cost contributors, pointing out the convergence and difference in published results, and give a view of the whole value chain towards scaling-up and commercialization when performing a techno-economic analysis (TEA).
\n
\n
4.1. TEA framework
\n
To achieve an optimal facility design, it is necessary to evaluate the tradeoff resulting from the interactions between technical advances and financing parameters. The technical objectives include maximizing microalgal biomass productivity, maximizing biogas yield via AD of biomass, and process stabilization. The economic objectives are to minimize the production cost and maximize the economic benefits. Figure 1 shows the TEA framework for the sustainability analysis of biogas production from microalgal biomass through anaerobic digestion. The whole biomass processing value chain is determined by the technology framework and progress through experimentally validated process specifics. Economic analysis is based on the process design, which includes the cost assessments and investment analysis. A decision-making platform is built for raw material suppliers, producers and stake holders in an economic perspective. Correspondingly, the economic consequences will direct the research & development of new technologies, which could form a dynamic connection and optimization framework.
\n
Figure 1.
TEA framework for biogas production from algae biomass.
\n
Environmental TEA (ETEA) extended the TEA framework with an environmental assessment based on a life cycle analysis [70]. The ETEA is based on the technology readiness level, which means the assessments are performed using the available data based on technology maturity. This would avoid a mismatch between the assessment methodology and the technology readiness level. For example, the whole biogas life cycle includes phases from the biomass cultivation to the final usage and end of life. Under current technology maturity, the whole data set is unavailable, which limits the assessments to certain life cycle phases.
\n
\n
\n
4.2. State of the art: TEA of microalgal biogas
\n
Biorefinery optimization and full utilization of biomass addressing in the economic viability and environmental sustainability of the production of algae biofuels can be found in [39, 71, 72]. Dutta et al. [72] analyzed the sustainability of microalgae-derived biofuel production by performing a TEA and life-cycle assessment and found that coproducts valorization is more energy efficient than the processes focusing on specific components such as lipids. Biorefineries with coproducts and byproducts could have better utilization of the algal biomass and can increase the revenue, thus show greater possibility of achieving economic feasibility. In microalgae biodiesel and bioethanol productions, anaerobic digestion is usually integrated into the biorefinery to treat the residues for energy and nutrient recovery. Sialve et al. [18] compared the energy recovery ratio for two scenarios: direct AD of the whole algae biomass and AD of residue biomass after lipid extraction. Direct AD of the whole biomass was considered to have a higher energetic recovery when the cell lipid content does not exceed 40%. Also, increased lipids content in microalgae is not generally compensated with increased productivity due to nitrogen limitation. The potential of direct AD of microalgae biomass was addressed in their research, taking into account the energetic recovery and necessary nutrient recycle for large-scale productions. Chia et al. [73] discussed the economic potential of biohydrogen and biogas production in Germany and Spain. Two processes were compared: direct AD of microalgae biomass (DAD) and coupled hydrogen and biogas production (CHB). In the CHB process, hydrogen was first produced by dark fermentation then effluent from hydrogen fermentation was used for biogas production. The CHB was found to have a lower operating cost due to no additional water and nutrients requirements for the bioreactor feed while the DAD process requires algal biomass in combination with other feedstocks. Both cases have production costs 13–16 times higher than the market price for natural gas. A 1/3 higher biogas yield and a 1/2 lower labor cost did not change the economic status of both processes, due to the high cost of fertilizer and building photobioreactors for microalgae cultivation. Milledge and Heaven [74, 129] performed an energy balance of biogas production from microalgae. Their research emphasized a combination of dewatering methods, as well as the efficient exploitation of the heat generated by the combustion of biogas in combined heat and power (CHP) units to show the energetic viability of the whole process.
\n
Chew et al. [68] assessed the potential of microalgae biorefineries for producing high-value products such as pigments, proteins, lipids, carbohydrates, and vitamins. The high-value products were added to improve the biorefinery economics. Open pond cultivation and medium recycling were mentioned to have better economic performance than other biorefinery structures. Water, land usage and capital cost were challenging for the economic viability of algal biofuels. The high-value products also need to improve aspects such as separations method, energy consumption, and control of product loss. AD was emphasized to recycle a considerable amount of nutrient usage to make microalgal fuels head towards its large-scale production. Several authors [13, 17, 37, 38, 75, 133, 134] synthesized scientific literature on biogas production from algae and suggested integration of the technology with other technologies as well as co-digestion with other substrates for an optimized biorefinery that sustainably produces biogas. Singh and Gu [76] recommended integrated processes that combine algae cultivation and wastewater treatment for methane production, which could offset the higher cost in comparison to methane production from corn and woody biomass.
\n
Zamalloa et al. [8] evaluated the techno-economic potential of methane production from microalgae. The assessment was carried out using high rate anaerobic digesters (10–20 kg COD/m3/d) and preconcentrated algae biomass from a full-scale open pond. The energy production cost from microalgal biogas was estimated to be 0.087–0.17 euro/kWh with an algae biomass cost of 86–124 euro/tonne. The result was based on a feed-in tariff of 0.133 euro/kWh and a carbon credit of 30 euro/ton of carbon dioxide. This study is one of the limited works that has been done on a comprehensive technological and economic assessment of electrical and thermal energy produced by biogas through AD of microalgae.
\n
Collet et al. [77] performed a life-cycle assessment (LCA) of biogas production from the microalgae Chlorella vulgaris and found that electricity consumption and the impacts generated by the production of methane from microalgae are strongly correlated. Decreasing mixing and heating cost in different production steps or increasing the efficiency of AD were important to reduce the overall cost.
\n
The studies surveyed show considerable variability in the calculated fuel cost and identifying the significant cost contributors. The varied results come from different conversion pathways, technical assumptions (productivity, reactor design, process parameters, etc.) and economic factors (interest rate, raw material cost, etc.), diverse environmental and social conditions (consideration of season and location), and validation of sub-process models (lab/pilot plant/commercial scales). Nevertheless, the contributors to the production cost are mainly identified as microalgal strain selection, biomass cultivation and harvesting, AD operating conditions, biogas upgrading methods, waste management, and type of biorefinery. Thomassen et al. [78] evaluated the methodological reason for the wide variation in the results of multiple environmental and economic assessments. They proposed an environmental techno-economic assessment which can help to solve the challenges for a sustainability assessment: framework for methodology, harmonized assumptions, and integration of different dimensions (stages of technological maturity, technological process). This method is based on the dynamic technological process parameters and the same system boundaries for an integrated TEA and LCA.
\n
\n
\n
4.3. Cost management
\n
Gnansounou and Dauriat [79] investigated TEAs following different types of cost management systems in value engineering, target costing and a combination of value engineering and target costing. Value engineering includes process design via data collection and process flowsheeting. Process simulators such as Aspen Plus enables the evaluation of the whole process chain based on scale up of the pilot plant, state of art technologies and price quotes. For microalgae to biogas technologies, key issues along the process chain include the suitable choice and operation options of the microalgae species, harvesting/dewatering strategies, pretreatment methods, AD configurations, recycling the digestate, and energy integration. Not all the steps are necessary for technologies with simplified processes and high economic potential. Target costing is a market-oriented method, which means a target selling price was set for the cost evaluation based on market and societal values. Following the target price, the target cost of the final product and each step of the supply process will be estimated, which means the cost allowance will play a key role in the process design. Target costing could integrate with value engineering in the cost management activities, so the cost allowance and cost target could be reconciliated. In the case of biogas production, the target costing evaluation seems unfeasible for the whole process due to the weak financial position of the natural gas market [80].
\n
Real options analysis framework was employed by Kern et al. [81] for TEA. The model was adapted to accept stochastic price data for energy and agricultural commodities as well as static operating parameters assumptions for the algal biofuel plants. The TEA work was combined with life cycle analysis in a dynamic system—the fluctuations in market prices for energy and agricultural commodities will influence the operation decisions of the biofuels plants and its associated environmental impacts. Areas such as carbon tax, resource shortage and market forces could be investigated for their impact on biofuel plant design and operations in a dynamic system in the future. This gives the stake holders and suppliers more flexibility in making decisions.
\n
\n
\n
4.4. TEA limitations
\n
The limitations of TEA include the potential competition for resources. For example, the microalgae biomass could have non-energy applications and has the potential for producing high value products besides biofuels. Then the biomass cost for the process will be influenced not only by the biomass production activities but also the market price which is determined by both the suppliers and purchase competitors.
\n
The sustainability of biogas production from microalgae will depend on not only the commercial viability but also environmental improvements such as greenhouse gas emission reduction, lack of direct and indirect impacts on land-use as well as biodiversity and eutrophication. The scope of TEA is limited for the environmental impact assessment, while these impact categories are appropriate for the goals of the overall sustainability analysis. Thus, an ETEA would allow assessing the sustainability of the entire value chain. Besides, TEA is not reflecting social impacts such as social awareness of algal biofuels’ non-food competitive characteristics, rural development, and public recognition.
\n
\n
\n
\n
5. Case study: TEA of anaerobic digestion of Cyanothece BG0011
\n
The microalgae used for this case study is a cyanobacterium, Cyanothece sp. BG0011 isolated from a shallow lake in Florida Keys [82]. Compared to other algal species, this species is endowed with unique features. First, cyanobacterium Cyanothece sp. BG0011 is a saline species and can be adapted to a wide range of salinities (10–70 psu). Second, it fixes dinitrogen in the air, which means it does not require nitrogenous nutrients in the culture water. Third, it produces exopolysaccharide (EPS) which can be converted to a variety of bioproducts. The aim of this case study is to assess the economic feasibility of biogas production using Cyanothece sp. BG0011 as feedstock by conducting a techno-economic assessment. The analysis investigated alternatives to decrease the cost and energy requirement of the cultivation and anaerobic digestion of algae. Utilization of biogas to produce electrical and thermal energy or upgrading to produce pure methane (renewable natural gas) was also considered. A comprehensive TEA was carried out based on experimental data and a set of operational assumptions which could be conceivably achieved in near term. The process flowsheet for biomass to biogas conversion through anaerobic digestion and biogas purification processes was implemented in Aspen Plus V8.8 to obtain mass balance and energy requirement results. The discussion focused on the preliminary exploration of the conceptual design of a microalgae cultivation and bioconversion system as well as an investigation on improvements that could result in the greatest system flexibility, energy yield and cost reductions.
\n
\n
5.1. Cyanothece BG0011 cultivation
\n
Results from many experiments [149] conducted in the Bioprocess Engineering Laboratory, Department of Agricultural and Biological Engineering, University of Florida gave an average growth rate of 67.5 mg afdw/L/day (20.25 g afdw/m2/day) for BG0011 cell biomass and an EPS production rate of 52.5 mg afdw/L/day (15.75 g afdw/m2/day), resulting in cell density of 2.7 g/L and EPS concentration of 2.1 g/L. The areal rates were calculated by assuming that the depth of culture was 30 cm, which is typically the case for open ponds. In the laboratory, the cultures were cultivated under air sparging, a constant illumination of 1200 μmol photons m−2 s−1 light and 13 h to 11 h light-dark cycle. Open raceway ponds are generally used for large-scale commercial production of algal biomass [86]. Productivity in industrial-scale raceway ponds is generally lower than in small experimental reactors. In literature, algae biomass productivity performance claims range from 7 to 35 g afdw/m2/day [23, 87, 88, 89] with corresponding net photosynthetic efficiencies from under 1–4%. Among these, for studies involving techno-economic analyses, the baseline productivity assumed was 20 g/m2/day, with an optimistic value of 25–30 g afdw/m2/day, and a conservative value of 15 g afdw/m2/day. In this study, which assumed that BG0011 is cultivated in current large commercial open ponds, an average productivity of 12.4 g afdw/m2/day (corresponding to a net photosynthetic efficiency of under 1%) was used. Similar growth rates were obtained by [148] when the algae was cultivated by air sparging and exposed to a lower light intensity of 122 μmol photons m−2 s−1 light and 13 h to 11 h light-dark cycle. Here, laboratory-scale BG0011 cell biomass growth rate is comparable to algae cell growth rates reported from other studies, however, in the case of BG0011, it also produces EPS. The average mass ratio between EPS and cell biomass is 0.778: 1 and also EPS production is cell-growth associated, so for this study it is assumed that in the commercial system, in addition to BG0011 cells, EPS would be concomitantly produced at 0.778 × 12.4 g afdw/m2/d = 9.6 g afdw/m2/day. The total algae biomass productivity used was 22 g/m2/d. Henceforth, the term “algae biomass” will include both BG0011 cells and EPS.
\n
The scale of algae cultivation in literature for techno-economic analysis ranges from 200 to 700 ktonne afdw/year [22, 27, 72, 89]. In the present study, the scale of algae cultivation was determined based on a hypothetical 20 million gallons per year ethanol plant. The sugar required for such a plant would be 128 ktonnes afdw/year (assuming yield of around 0.42 g ethanol/g sugar, and 1.1 g sugar/g polysaccharide). Assuming this amount of sugar will be supplied in the form of EPS, the scale of the algae cultivation pond would be 293 ktonnes of algal biomass/year, which also includes BG0011 cell biomass. This scale falls into the range of values found in literature for TEA. To meet a production capacity of 293 ktonnes/year at algal biomass productivity of 22 g afdw/m2/day, land area required would be 3660 hectares (approximately 4 × 4 miles). For a sanity check, this cultivation area was compared to land area required to supplying corn grain for a 20 million gallon per year corn-ethanol plant. Based on annual corn grain yield of 7000 kg/ha with starch content of 72% [150], and assuming a conversion of 0.5 kg ethanol/kg of starch, land required would be 23,700 ha. In this case the total above ground biomass productivity of corn, including corn grain, stover and cobs, is 16,700 kg/ha/year [150] whereas for BG0011 it is anticipated to be 80,300 kg/ha/year.
\n
The BG0011 cultivation cost was estimated based on vendor quotes, literature, or engineering estimates. The installed pond capital cost includes civil work, liner, piping, electrical, other pond costs (such as paddlewheels). In addition, pumps for pumping water from ponds to refinery and for refilling the pond and required land also incur significant capital costs. Plastic lined earthen ponds were chosen for its lower cost compared to concrete ponds. Larger pond sizes would enable economically viable algal biomass production [23]. Here, the installed capital cost was estimated based on “dollars/hectare” of growth ponds for simplicity. The installed pond cost was set to be 80,000 $/ha. Literature value ranges from 46,000 $/ha to more than 150,000 $/ha (value adjusted for inflation) due to different liner scenarios (partial or full) and specific design (e.g. with or without equipment to minimize dead zones) [23, 86] which was not included here. A land cost of 3080 $/acre [90] was used for low-value land. The operation cost for algae cultivation such as utilities, chemicals, labor, overheads, maintenance, insurance tax, etc. were estimated using engineering estimates [91]. BG0011 was assumed to be cultivated in seawater or brackish water. The only fertilizer used for BG 0011 cultivation is phosphorus since it uses dinitrogen in air as a nitrogen source, and seawater would supply rest of micronutrients. From laboratory experiments it was determined that the phosphorous requirement of BG001 is 8.9 mg/L [149], so the annual requirement of phosphorous will be 1186.7 tonnes. Here, triple superphosphate (Ca(H2PO4)2 H2O) which contains 24.6% P is used as phosphorous source with a price of 270 $/tonne (Source: World Bank, 2017). The requirement of triple superphosphate is 4945 tonne/year.
\n
The fixed capital investment was assumed to be borrowed at an interest rate of 10% for 20 years. The plant operates 24 h a day and 360 days annually. The prices were adjusted for Year 2017 using Chemical Engineering Plant Cost Index (CEPCI). These assumptions were also used for the analysis of subsequent biogas production, conversion and upgrading processes. The production cost was calculated as follows:
\n
\n\n Unit production cost\n=\n\n\n(Annual capital charges+Total operating cost)\n\n\n −\nCoproduct credits)\n\n\n/\n\nAnnual production\n\n\nE1
\n
Here, the annual capital charges are calculated as follows:
\n
\n\n Annual capital charges\n =\n\n\nTotal capital cost\n∗\nInterest rate\n∗\n\n\n(1\n +\nInterest rate)\n\n\n^\n\nLoan period\n\n\n\n/\n\n\n\nInterest rate\n\n^\n\nLoan period\n\n−\n1\n\n\n\nE2
\n
* Total capital cost = Total fixed cost + Working capital.
\n
* Working capital is 10% of fixed capital.
\n
\n
\n
5.2. Anaerobic digestion
\n
The anaerobic digester was designed to treat the un-dewatered whole algae culture from the pond. The energy-intensive steps like algae harvesting and dewatering are avoided in this process which is different from most research [8, 22, 23]. The product biogas was analyzed for economic performance in two different applications: biogas purification or electricity production through combined heat and power.
\n
The first step in modeling mass flow rate of reactor outputs and determining energy requirements is to establish the stoichiometry of reactions. The stoichiometry of methane fermentation of algae biomass was developed based on the following assumptions: (1) microbial cells (cyanobacteria and bacteria) can be represented by the empirical formula CH1.8O0.5N0.2 [151]; (2) EPS is pure polysaccharide represented by the empirical formula C6H10O5; (3) algae biomass can be represented by an empirical formula containing the elements C, H, O and N in the mass ratios in which cells and EPS are produced that is 1:1.2; and (4) methane yield from laboratory assays corresponds to complete decomposition of substrate. The empirical formula for algae biomass was CH1.73O0.67N0.1. The stoichiometry for methane formation is written as follows:
Methane yield from algae biomass was measured in the laboratory to be 300 ml at STP (g afdw)−1. This corresponds to 0.35 moles of methane (mole algae biomass)−1, which is equal to value of ‘c’ in the above stoichiometry. The other stoichiometric coefficients can now be solved from elemental balances for C, H, O and N. The stoichiometry is
In the anaerobic digester it was assumed that 98% of the algae biomass is converted. Different scenarios (three anaerobic digester types) were investigated to evaluate the economic and energetic performance. A schematic of biorefinery scenarios are shown in Figure 2.
\n
Figure 2.
Schematic diagram showing biorefinery scenarios.
\n
Case 1. Above ground mesophilic anaerobic digester. In Aspen, the influent to the reactor was 15 ktonne/h. The temperature was maintained at 37°C. It was operated at an HRT of 25 days.
\n
Case 2. Above ground low-temperature anaerobic digester. Anaerobic digestion at low temperatures (LTAD) was applied to improve the energy balance. In this scenario the digester is operated in the psychrophilic range (12–20°C) [92, 93, 94]. However, with the same flow rate, the digester volume is larger to achieve a higher HRT for LTAD than mesophilic and thermophilic anaerobic digestion. Here, the temperature of LTAD is set to 20°C with an HRT of 50 days.
\n
Case 3. Covered anaerobic lagoon. Covered anaerobic lagoon (CAL) does not require additional energy for the biogas production because no heating or mixing processes are involved. Besides, it is economical to construct and operate. The CAL in this research was 6 meters deep and covers an area of 1.5 hectares based on literature data [95]. The HRT was set to 50 days. The cost includes anaerobic lagoon excavation, cut and fill, lagoon liner, inlet and out structures, lagoon cover, ancillaries, pipework & installation, contingencies, design, engineering, etc. Operating costs including utility usage are minimal.
\n
In all three cases above, the capital cost of anaerobic digester was estimated using vendor quotation or literature values. The operating cost was estimated by Aspen Process Economic Analyzer.
\n
\n
\n
5.3. Biogas purification
\n
Several biogas upgrading or purification methods are available such as high-pressure water scrubbing, membrane, pressure swing, gas permeation and chemical scrubbing. High pressure water scrubbing and chemical scrubbing (using amine solutions—MEA) are two of the most commonly used processes.
\n
The MEA scrubbing method uses aqueous monoethanolamine (MEA) for acidic gas removal. The concentration of amine for acidic gas absorption is usually below 30% (by weight). The amine process has two main steps, absorption and stripping [96]. The detailed MEA scrubbing process is shown in Figure 3. Raw biogas goes through a scrubbing column in which MEA is flowing counter-current to biogas. The CO2-rich MEA is collected at the bottom of the scrubbing column and pumped into a stripping column to remove CO2 and regenerate MEA by heating. Similar to MEA scrubbing, high pressure water scrubbing was also employed for biogas upgrading: biogas is fed to the bottom of scrubber after compressing it to 10 bar. At the top of scrubber, pressurized water is fed. CO2-rich water is then transferred to a flash column with a lower pressure of 3 bar to release gases for feed recirculation and minimizing methane loss. Then the CO2-rich water goes through a CO2 desorption process from the water stream by air [97]. Both biogas purifying approaches were simulated in ASPEN Plus to determine the economics of each approach. The technical specification details are shown in Table 3. The table shows high pressure water scrubbing to be a more economical alternative and was chosen for the integrated process.
\n
Figure 3.
MEA scrubbing for biogas upgrading.
\n
\n
\n
\n
\n\n
\n
Specification
\n
MEA
\n
High pressure water scrubbing
\n
\n\n\n
\n
Thermodynamic method
\n
ELECNRTL
\n
PSRK
\n
\n
\n
Scrubbing column
\n
RadFrac, 15 stages, pressure: 1.2 bar
\n
RadFrac, 10 stages, pressure: 10 bar
\n
\n
\n
Stripping column
\n
RadFrac, 15 stages, pressure: 8 bar
\n
RadFrac, 10 stages, pressure: 1 bar
\n
\n
\n
Make up chemicals
\n
Water: 150 kmol/h MAE: 750 kmol/h
\n
Water: 11500 kmol/h
\n
\n
\n
Solvent recycle rate
\n
MEA: 0.99
\n
Water: 0.95
\n
\n
\n
Methane loss
\n
1%
\n
0.3%
\n
\n
\n
Product methane purity
\n
95 wt%
\n
99.2 wt%
\n
\n
\n
Capacity (raw biogas flow rate)
\n
948.5 kmol/h
\n
948.5 kmol/h
\n
\n
\n
Capital cost (million $)
\n
8.2
\n
12
\n
\n
\n
Operating cost (million $/year)
\n
20
\n
4.6
\n
\n
\n
Utility cost (million $/year)
\n
17
\n
2
\n
\n
\n
Purification cost ($/kg of methane)
\n
0.3
\n
0.09
\n
\n\n
Table 3.
Technical and economic aspects of the biogas purifying systems in ASPEN V 8.8.
\n
\n
\n
5.4. Power generation from biogas
\n
While the raw biogas can be purified to obtain biomethane, another option is to use the raw biogas to produce heat and power. Steam and electricity can be generated by burning the raw biogas through a combined heat and power (CHP) system. For reference, the CHP system uses General Electric Jenbacher JGS 420 system which is a 1425 kw generator. The total capital cost is $ 1,150,000 (including installation, tax, etc. 2007), which is 807 $/kw. The working capital is 10% of the total capital. The operating cost includes direct operating cost such as operating labor, supervised labor, maintenance and repairs, as well as indirect operating cost such as overhead, taxed, insurances. It is assumed that 40% biogas energy is for electricity, 50% for steam, 10% loss.
\n
\n
\n
5.5. Techno-economic analysis of integrated system
\n
\n
5.5.1. Biomass cultivation economics
\n
The BG0011 cultivation economics analysis details are shown in Table 4. In the literature algae production costs range from 150 to 6000 $/tonne [19, 22, 27, 72, 89, 142], however, the studies vary from assumptions (production scale, chemical prices, plant life, etc.) to differences in technical specification (photobioreactor design, algal species, etc.). Some of the estimates also account costs for dewatering of algae [22, 27]. Thus, it is difficult to make a direct comparison between different studies. Besides, specific assumptions in each study could be based on different social-economic conditions, which makes comparisons more complicated [98].
\n
\n
\n
\n\n
\n
Parameters
\n
Values
\n
\n\n\n
\n
Production scale
\n
\n
\n
\n
BG0011 cells production (ktonne/year)
\n
165
\n
\n
\n
BG0011 EPS production (ktonne/year)
\n
128
\n
\n
\n
Total algae biomass production (ktonne/year)
\n
293
\n
\n
\n
Capital cost (including fixed, installed and working capital)
\n
\n
\n
\n
Pond (million $)
\n
308
\n
\n
\n
Land (million $)
\n
26.6
\n
\n
\n
Pump (million $)
\n
7.85
\n
\n
\n
Total capital cost (million $)
\n
342.45
\n
\n
\n
Annual capital charges (million $/year)
\n
40.22
\n
\n
\n
Operating cost
\n
\n
\n
\n
Chemicals (P fertilizer: Ca (H2PO4)2 H2O) (million $/year)
\n
1.3
\n
\n
\n
Other operating cost (including utilities, maintenance and repairs, labor etc.) (million $/year)
\n
3.26
\n
\n
\n
Total operating cost (million $/year)
\n
4.56
\n
\n
\n
BG0011 algae biomass production cost ($/tonne)
\n
153
\n
\n\n
Table 4.
Algae cultivation economics.
\n
\n
\n
5.5.2. Economics of anaerobic digestion
\n
Details of the production cost of renewable natural gas for the three anaerobic digestion scenarios are shown in Table 5. Case 2 contains two scenarios: The size of anaerobic digester in Case 2(a) is two times of that in Case 1. This is because the hydraulic retention time is longer under lower temperature, the volume of digester needs to be larger to keep the same production scale (the inflow rate). The size of anaerobic digester in Case 2(b) is the same as Case 1. Keeping the digester volume same as Case 1, because the temperature is lower, the productivity will be lower as well. Thus Case 2(b) has a lower production scale compared to other cases. The effect of temperature was incorporated by using the empirical relationship that for every 10°C rise in temperature the degradation rate is doubled. As the difference between the temperature for Case 1 and Case 2 is 17°C, it is expected that in Case 1, the digester has a processing capacity twice as much as that of the digester in Case 2b. The main contributor to the production cost of biogas is the biomass cost. Considering a carbon credit of 10 $/tonne of CO2, the production cost of biogas only drops 0.5 $/MMBtu. The results are comparable to Zamalloa et al.’s [8] research (the only paper focusing on the economics of renewable energy through AD, to our best knowledge): 32.2–61.5 $/MMBtu with the algae biomass cost of 115.4–166.4 $/tonne (0.087–0.17 euro/kwh with an algae biomass cost of 86–124 euro/tonne, 2011). The methane yield is 0.012 MMBtu/kg of VS biomass, which is in close agreement to our experimental result 0.0124 MMBtu/kg of VS biomass.
\n
\n
\n
\n
\n
\n
\n\n
\n
Item
\n
Case 1 (mesophilic anaerobic digester)
\n
Case 2(a) (low-temperature anaerobic digester)
\n
Case 2(b) (low-temperature anaerobic digester
\n
Case 3 (covered anaerobic lagoon)
\n
\n\n\n
\n
Biogas production scale (106 MMBtu/year)
\n
3.7
\n
3.7
\n
1.85
\n
3.7
\n
\n
\n
Fixed capital cost of anaerobic digester (million $)
\n
67.12
\n
102
\n
67.12
\n
7.5
\n
\n
\n
Capital cost except anaerobic digester (million $)
\n
16.3
\n
16.3
\n
12.3
\n
16.4 (including land: $11400)
\n
\n
\n
Annual capital charges (million $/year)
\n
9.8
\n
13.9
\n
9.3
\n
2.8
\n
\n
\n
Total raw materials (algae biomass) cost (million $/year)
\n
44.8
\n
44.8
\n
44.8
\n
44.8
\n
\n
\n
Other operating (labor, utility, indirect, etc.) cost (million $/year)
\n
25.8
\n
7.1
\n
4.4
\n
7.1
\n
\n
\n
Utility cost (million $/year)
\n
21
\n
2.3
\n
1.4
\n
2.3
\n
\n
\n
Renewable natural gas production cost ($/MMBtu)
\n
21.7
\n
17.8
\n
31.6
\n
14.8
\n
\n\n
Table 5.
Process and economic assessment for purified biogas production through anaerobic digestion of Cyanothece BG0011 biomass.
\n
\n
\n
5.5.3. Electricity production cost
\n
On an energy potential basis, 40% of total methane produced per year could support a 50 MW power plant. Current residential electricity price is around 12 cents/kwh, while industrial price is around 7 cents/kwh. As shown in Table 6, the electricity production cost from biogas is 13 cents/kwh. Renewable energy technologies are usually more expensive than fossil fuel technologies. The reasons could be environmental costs associated with fossil fuels that are not paid by the rate payers, mechanical difficulty in bioenergy production, start-up issues and so on. European countries such as Germany and UK governments subsidize the production of renewable energy by introducing feed-in tariffs. These tariffs may be important to make bioenergy industry profitable.
\n
\n
\n
\n\n
\n
Item
\n
Value
\n
\n\n\n
\n
Electricity capacity (million kwh/year)
\n
435
\n
\n
\n
Total capital cost of the CHP system (million $) (including fix capital cost and 10% working capital)
\n
52.4
\n
\n
\n
Capital charges (million $/year)
\n
6.2
\n
\n
\n
Steam credits (million $/year)
\n
3.7
\n
\n
\n
Raw biogas cost (million $/year)
\n
47.7
\n
\n
\n
Other operating cost (million $/year)
\n
9.5
\n
\n
\n
Electricity production cost ($/kwh)
\n
0.13
\n
\n\n
Table 6.
The economics of biogas—electricity and steam system.
\n
\n
\n
\n
\n
6. Cost minimization approaches
\n
\n
6.1. Nutrient recycling and biogas upgrading
\n
Nutrient (mostly nitrogen and phosphorous) recycling such as utilizing the digestate or wastewater for microalgae cultivation was highlighted in various studies [59, 60, 61, 62, 63, 104, 105, 106, 107, 126, 128, 138, 139]. Recycling the effluent from the anaerobic digester for algae cultivation could mitigate the costs associated with supplying nutrient for algal biomass growth and effluent treatment. Erkelens et al. [59] validated that microalgae Tetraselmis sp. could utilize its digested effluent as a growth medium and thus form a closed loop system. Also, Prajapati et al. [60] showed that algal liquid digestate have good potential to be utilized as nutrient supplement (30% concentration) in rural sector wastewater for biomass cultivation. The biomass production level is closer to the case in which conventional medium is used. Although there are still technological obstacles when growing microalgae on digestate such as low growth rate due to poor nutrient ratios, shading, ammonia inhibition and bacteria growth, the performance of the nutrient recycling process could be further developed by scale up/optimizing strategies such as controlling inoculum and substrate concentrations, bacteria growth as well as harvesting strategies [59, 61, 64, 132].
\n
One option to increase algae biomass productivity and its concentration in the culture is to enrich the air with CO2. It has been shown that enriching the air with 1% CO2 increases cell concentration to 3.46 g afdw/L and EPS concentration to 2.91 g afdw/L, giving an algae biomass concentration of at least 6.37 g afdw/L [149], which is 1.33 times more than that used in the case study above. The increased productivity of algae biomass will reduce further the cost for biomass production. The CO2 released from the biogas upgrading process or waste gases from biogas combustion containing CO2 could be recycled to the algae growth ponds for enriching the air. The economic analysis for this scenario was also performed assuming algae biomass concentration is 1.33 times the previous value of 293 ktonne/year. The estimated production cost for Cyanothece BG 0011 algae biomass is 121.6 $/tonne. This was calculated by accounting for the following additional costs: (1) capital cost associated with pipes and pumps to take CO2 from biogas purification system or biogas combustion output to the pond and (2) operating costs resulting from more nutrient addition to maintain higher cell density and power consumption of compressing CO2 for sparging [152]. Only biogas production from covered anaerobic lagoon as in Case 3 was considered here. Algae production cost was lowered by 20%. The estimated cost of renewable natural gas is now reduced to 12.16 $/MMBtu and the electricity production cost from biogas is only 10.98 cents/kwh.
\n
Upgrading biogas by fixation of the CO2 in biogas via photosynthesis by microalgae has been investigated with respect to CO2 removal capability, biomass productivity and O2 desorption minimization [16, 63, 64, 65, 66, 67]. Toledo-Cervantes et al. [16] optimized the biogas upgrading process by studying the influence of the recycling liquid to biogas ratio. The biomethane produced met specification for injection into natural gas grids. However, this technique requires closed photobioreactors. Hydrogen sulfide (H2S) is another contaminant to be removed from the biogas. Hydrogen sulfide removal was realized by the oxidation of H2S to sulfate by sulfur oxidizing bacteria that used the oxygen produced photosynthetically in situ. In this case, the algae-bacteria symbiosis was employed in the photobioreactors [67]. Nutrient recycling and biogas upgrading provides not only the opportunity for AD of microalgal biomass to be cost-effective, but also the potential to reduce the environmental impacts.
\n
To move industrial application of biogas production from microalgal biomass towards commercialization, additional assessment is required regarding large scale operations. These include (1) strain robustness, outdoor productivity, location and seasonal effects, yield from real production systems, and harvesting strategy for algae cultivation (2) for biomass to biogas conversion processes, the conceptual process design needs to take the following factors into consideration: costs associated with digester heating, land, and infrastructure as well as operational parameters such as maintaining pH, temperature, mixing, power consumption, and production of coproducts like fertilizer.
\n
\n
\n
6.2. Dynamic growth models
\n
The uncertainty of large-scale algae cultivation is still a challenge which prevents commercialization; process modeling could provide useful information about the performance of microalgae cultivation systems by estimation and optimization of microalgae productivity under different conditions [103]. A growth kinetic model is critical in a process model simulating microalgae cultivation which has a direct impact on downstream conversion processing systems [135] Lee et al. [31] classified the existing kinetic models into three groups: a single limiting substrate (phosphorus, or dissolved CO2 concentration), a physical limiting factor (light intensity or temperature), and multiple factors (e.g. both substrate and light). Based on their study, there was a tradeoff between the accuracy of the model representation and real-world usability. A future modeling framework should consider along with limiting nutrients, integration of light and temperature, and incorporation of species diversity.
\n
\n
\n
6.3. Biorefinery concepts
\n
AD can be integrated to biorefineries which produce high value products from algae such as chemicals for cosmetics, nutraceuticals and pharmaceuticals. This requires diversified business strategies which benchmark the market potential for the total raw materials and alternative products. In the economic perspective, three approaches could be possible for the development of microalgae AD: (1) implementing AD for biogasification of cell debris or waste streams in microalgal based processes such as biodiesel/bioethanol/high-value bioproducts (e.g. PHA)/fuel cell/hydrothermal liquefaction/hydrogen production [68, 120]; (2) investigation of high-value products from intermediate metabolites produced during AD such as carboxylic acids [37]; (3) electricity production from microalgae derived biogas. In previous sections, the cost of electricity from microalgae derived biogas is comparable with market value while cost of the renewable natural gas from microalgae is much higher than the current market value of natural gas.
\n
\n
\n
\n
7. Conclusion and future work
\n
This chapter reviewed the literature on TEA of biogas production from algae. The key drivers to the overall production cost were identified and possible process improvements to reduce cost were discussed. The need for harmonization of resource, life cycle and techno-economic assessments in the methodology of TEA was highlighted. Modeling efforts, based on well-informed, rigorous engineering-based process models, should be integrated on a baseline framework such that different process technologies, subprocesses and alternative pathways can be directly compared at a system level. TEA model improvements include strategic planning and using reliable input data from simple mass balance calculations to geographically and seasonally specific assessments, as well as risk analysis for large-scale productivity. Nutrient recycling process has the potential to reduce both cost and environmental burdens.
\n
The cultivation of microalgae BG0011 and its economic feasibility as an energy source through anaerobic digestion was evaluated through a techno-economic analysis. The main contribution to the biogas cost is the biomass production cost. The best-case estimate was a biomethane production cost of 14.8 $/MMBtu using covered anaerobic lagoon and high-pressure water scrubbing purification. The cost of electricity production from biogas was estimated to be 13 cents/kwh. Even though these costs are higher than commercial prices in the United States, these are much lower than those costs with production of liquid fuels like ethanol or biodiesel from algae.
\n
Improved algal biomass productivities could be essential for lowering the cost of algae-derived biogas. This could be achieved by recycling the CO2 released during biogas upgrading or combustion for algae cultivation. Algal biogas economics could be further improved by marketing the digester sludge as a soil-amendment product, considering that nitrogen in the sludge was fixed from atmospheric dinitrogen.
\n
\n
Acknowledgments
\n
The authors gratefully acknowledge funding provided by Office of Energy, Florida Department of Agricultural and Consumer Services under contract number 92420 for this project.
\n
Conflict of interest
The authors declare that there are no potential financial or other interests that could be perceived to influence the outcomes of the research.
\n',keywords:"microalgae, anaerobic digestion, biogas, techno-economic analysis, Cyanothece BG0011",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/66930.pdf",chapterXML:"https://mts.intechopen.com/source/xml/66930.xml",downloadPdfUrl:"/chapter/pdf-download/66930",previewPdfUrl:"/chapter/pdf-preview/66930",totalDownloads:2141,totalViews:1,totalCrossrefCites:15,dateSubmitted:"September 11th 2018",dateReviewed:"March 27th 2019",datePrePublished:"April 27th 2019",datePublished:"September 4th 2019",dateFinished:"April 27th 2019",readingETA:"0",abstract:"Microalgae are a promising feedstock for bioenergy due to higher productivity, flexible growing conditions, and high lipid/polysaccharide content compared to terrestrial biomass. Microalgae can be converted to biogas through anaerobic digestion (AD). AD is a mature technology with a high energy return on energy invested. Microalgae AD can bypass energy intensive dewatering operations that are associated with liquid fuel production from algae. A techno-economic assessment of the commercial feasibility of algae-based biogas production was conducted using Cyanothece BG0011 biomass as an example. BG0011 is a naturally occurring, saline cyanobacterium isolated from Florida Keys. It fixes atmospheric nitrogen and produces exopolysaccharide (EPS). Maximum cell density and EPS concentration of 2.7 and 2.1 g afdw1/L (for total algae biomass concentration of 4.8 g afdw/L) were obtained by air sparging. For an areal cell and EPS productivity of 12.4 and 9.6 g afdw/m2/day, respectively, the biomethane production cost was 14.8 $/MMBtu using covered anaerobic lagoon and high-pressure water scrubbing for biogas purification. Electricity production from biogas costs 13 cents/kwh. If areal productivity was increased by 33% from the same system, by sparging air enriched with 1% CO2, then biomethane cost was reduced to 12.16 $/MMBtu and electricity cost to 11 cents/kwh.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/66930",risUrl:"/chapter/ris/66930",signatures:"Na Wu, Cesar M. Moreira, Yingxiu Zhang, Nguyet Doan, Shunchang Yang, Edward J. Phlips, Spyros A. Svoronos and Pratap C. Pullammanappallil",book:{id:"6839",type:"book",title:"Anaerobic Digestion",subtitle:null,fullTitle:"Anaerobic Digestion",slug:"anaerobic-digestion",publishedDate:"September 4th 2019",bookSignature:"J. Rajesh Banu",coverURL:"https://cdn.intechopen.com/books/images_new/6839.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:"978-1-83881-850-0",printIsbn:"978-1-83881-849-4",pdfIsbn:"978-1-83881-851-7",isAvailableForWebshopOrdering:!0,editors:[{id:"218539",title:"Dr.",name:"Rajesh Banu",middleName:null,surname:"Jeyakumar",slug:"rajesh-banu-jeyakumar",fullName:"Rajesh Banu Jeyakumar"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"157581",title:"Dr.",name:"Pratap",middleName:null,surname:"Pullammanappallil",fullName:"Pratap Pullammanappallil",slug:"pratap-pullammanappallil",email:"pcpratap@ufl.edu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"274349",title:"Ph.D.",name:"Na",middleName:null,surname:"Wu",fullName:"Na Wu",slug:"na-wu",email:"wuna8703@ufl.edu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"University of Florida",institutionURL:null,country:{name:"United States of America"}}},{id:"276285",title:"Dr.",name:"Yingxiu",middleName:null,surname:"Zhang",fullName:"Yingxiu Zhang",slug:"yingxiu-zhang",email:"yingxiu.zhang88@gmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"Tianjin University",institutionURL:null,country:{name:"China"}}},{id:"276286",title:"Dr.",name:"Shunchang",middleName:null,surname:"Yang",fullName:"Shunchang Yang",slug:"shunchang-yang",email:"jack.shushu87@gmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"University of Florida",institutionURL:null,country:{name:"United States of America"}}},{id:"276289",title:"Dr.",name:"Doan",middleName:null,surname:"Nguyet",fullName:"Doan Nguyet",slug:"doan-nguyet",email:"dtmnguyetagu@gmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"276290",title:"Dr.",name:"Spyros",middleName:null,surname:"Svoronos",fullName:"Spyros Svoronos",slug:"spyros-svoronos",email:"svoronos@ufl.edu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"University of Florida",institutionURL:null,country:{name:"United States of America"}}},{id:"289093",title:"Dr.",name:"Edward",middleName:null,surname:"Phlips",fullName:"Edward Phlips",slug:"edward-phlips",email:"phlips@ufl.edu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"University of Florida",institutionURL:null,country:{name:"United States of America"}}},{id:"299854",title:"Dr.",name:"Cesar",middleName:"M",surname:"Moreira",fullName:"Cesar Moreira",slug:"cesar-moreira",email:"cemoreir@espol.edu.ec",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"Escuela Superior Politecnica del Litoral",institutionURL:null,country:{name:"Ecuador"}}}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Anaerobic digestion",level:"1"},{id:"sec_3",title:"3. Key drivers of microalgal biogas production cost",level:"1"},{id:"sec_3_2",title:"3.1. Microalgae cultivation, harvesting and dewatering",level:"2"},{id:"sec_4_2",title:"3.2. Anaerobic digestion systems",level:"2"},{id:"sec_4_3",title:"3.2.1. Pretreatment",level:"3"},{id:"sec_5_3",title:"3.2.2. Hydraulic retention time (HRT), organic loading rate (OLR), and reactor configurations",level:"3"},{id:"sec_6_3",title:"3.2.3. Temperature, pH, salinity, sulfur, and lipids content",level:"3"},{id:"sec_7_3",title:"3.2.4. C/N ratio",level:"3"},{id:"sec_8_3",title:"3.2.5. Other factors",level:"3"},{id:"sec_9_3",title:"Table 2.",level:"3"},{id:"sec_12",title:"4. Techno-economic analysis",level:"1"},{id:"sec_12_2",title:"4.1. TEA framework",level:"2"},{id:"sec_13_2",title:"4.2. State of the art: TEA of microalgal biogas",level:"2"},{id:"sec_14_2",title:"4.3. Cost management",level:"2"},{id:"sec_15_2",title:"4.4. TEA limitations",level:"2"},{id:"sec_17",title:"5. Case study: TEA of anaerobic digestion of Cyanothece BG0011",level:"1"},{id:"sec_17_2",title:"5.1. Cyanothece BG0011 cultivation",level:"2"},{id:"sec_18_2",title:"5.2. Anaerobic digestion",level:"2"},{id:"sec_19_2",title:"5.3. Biogas purification",level:"2"},{id:"sec_20_2",title:"5.4. Power generation from biogas",level:"2"},{id:"sec_21_2",title:"5.5. Techno-economic analysis of integrated system",level:"2"},{id:"sec_21_3",title:"Table 4.",level:"3"},{id:"sec_22_3",title:"Table 5.",level:"3"},{id:"sec_23_3",title:"Table 6.",level:"3"},{id:"sec_26",title:"6. Cost minimization approaches",level:"1"},{id:"sec_26_2",title:"6.1. Nutrient recycling and biogas upgrading",level:"2"},{id:"sec_27_2",title:"6.2. Dynamic growth models",level:"2"},{id:"sec_28_2",title:"6.3. Biorefinery concepts",level:"2"},{id:"sec_30",title:"7. 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Renewable and Sustainable Energy Reviews. 2016;65:235-249\n'},{id:"B137",body:'Santos-Ballardo DU, Rossi S, Reyes-Moreno C, Valdez-Ortiz A. Microalgae potential as a biogas source: Current status, restraints and future trends. Reviews in Environmental Science and Bio/Technology. 2016;15(2):243-264\n'},{id:"B138",body:'Wang X, Bao K, Cao W, Zhao Y, Hu CW. Screening of microalgae for integral biogas slurry nutrient removal and biogas upgrading by different microalgae cultivation technology. Scientific Reports. 2017;7(1):5426\n'},{id:"B139",body:'Lu D, Zhang XJ, Liu X, Zhang L, Hines M. Sustainable microalgae cultivation by using anaerobic centrate and biogas from anaerobic digestion. Algal Research. 2018;35:115-124\n'},{id:"B140",body:'Harun R, Davidson M, Doyle M, Gopiraj R, Danquah M, Forde G. Technoeconomic analysis of an integrated microalgae photobioreactor, biodiesel and biogas production facility. Biomass and Bioenergy. 2011;35(1):741-747\n'},{id:"B141",body:'Barlow J, Sims RC, Quinn JC. Techno-economic and life-cycle assessment of an attached growth algal biorefinery. Bioresource Technology. 2016;220:360-368\n'},{id:"B142",body:'Batan LY, Graff GD, Bradley TH. Techno-economic and Monte Carlo probabilistic analysis of microalgae biofuel production system. Bioresource Technology. 2016;219:45-52\n'},{id:"B143",body:'Saharan BS, Sharma D, Sahu R, Sahin O, Warren A. Towards algal biofuel production: A concept of green bio energy development. Innovative Romanian Food Biotechnology. 2013;12:1\n'},{id:"B144",body:'Stiles WA, Styles D, Chapman SP, Esteves S, Bywater A, Melville L, et al. Using microalgae in the circular economy to valorise anaerobic digestate: Challenges and opportunities. Bioresource Technology. 2018;267:732-742\n'},{id:"B145",body:'Kavitha S, Subbulakshmi P, Banu JR, Gobi M, Yeom IT. Enhancement of biogas production from microalgal biomass through cellulolytic bacterial pretreatment. Bioresource Technology. 2017;233:34-43\n'},{id:"B146",body:'Kavitha S, Banu JR, Priya AA, Uan DK, Yeom IT. Liquefaction of food waste and its impacts on anaerobic biodegradability, energy ratio and economic feasibility. Applied Energy. 2017;208:228-238\n'},{id:"B147",body:'Kavitha S, Kannah RY, Banu JR, Kaliappan S, Johnson M. Biological disintegration of microalgae for biomethane recovery-prediction of biodegradability and computation of energy balance. Bioresource Technology. 2017;244:1367-1375\n'},{id:"B148",body:'Doan NT. Assessing and Enhancing Methane Productivity from Anaerobic Digestion Using Cyanothece BG0011 as Feedstock [Doctoral Dissertation]: University of Florida; 2017\n'},{id:"B149",body:'Zhang Y. Cultivation, growth optimization and modeling of a saline Cyanothece species BG0011 for production of biofuels and bioproducts [doctoral dissertation]. University of Florida; 2018\n'},{id:"B150",body:'Brown RC, Brown TR. Biorenewable Resources: Engineering New Products from Agriculture. Hoboken, New Jersey: John Wiley & Sons; 2013\n'},{id:"B151",body:'Doran PM. Bioprocess Engineering Principles. Cambridge, Massachusetts: Academic Press; 1995\n'},{id:"B152",body:'McCollum DL, Ogden JM. Techno-economic models for carbon dioxide compression, transport, and storage & correlations for estimating carbon dioxide density and viscosity. [Internet]. 2006. Available from: https://escholarship.org/uc/item/1zg00532 [Accessed: 2018-12-05]\n'}],footnotes:[{id:"fn1",explanation:"Ash free dry weight."}],contributors:[{corresp:"yes",contributorFullName:"Na Wu",address:"wuna8703@ufl.edu",affiliation:'
Department of Agricultural and Biological Engineering, University of Florida, USA
'},{corresp:null,contributorFullName:"Cesar M. Moreira",address:null,affiliation:'
Department of Agricultural and Biological Engineering, University of Florida, USA
Faculty of Mechanical Engineering and Production Sciences, ESPOL Polytechnic University, Ecuador
Department of Agricultural and Biological Engineering, University of Florida, USA
'},{corresp:null,contributorFullName:"Edward J. Phlips",address:null,affiliation:'
Department of Fisheries and Aquatic Science, University of Florida, USA
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Department of Chemical Engineering, University of Florida, USA
'},{corresp:null,contributorFullName:"Pratap C. Pullammanappallil",address:null,affiliation:'
Department of Agricultural and Biological Engineering, University of Florida, USA
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The company was founded in Vienna in 2004 by Alex Lazinica and Vedran Kordic, two PhD students researching robotics. While completing our PhDs, we found it difficult to access the research we needed. So, we decided to create a new Open Access publisher. A better one, where researchers like us could find the information they needed easily. The result is IntechOpen, an Open Access publisher that puts the academic needs of the researchers before the business interests of publishers.
",metaTitle:"Our story",metaDescription:"The company was founded in Vienna in 2004 by Alex Lazinica and Vedran Kordic, two PhD students researching robotics. While completing our PhDs, we found it difficult to access the research we needed. So, we decided to create a new Open Access publisher. A better one, where researchers like us could find the information they needed easily. The result is IntechOpen, an Open Access publisher that puts the academic needs of the researchers before the business interests of publishers.",metaKeywords:null,canonicalURL:"/page/our-story",contentRaw:'[{"type":"htmlEditorComponent","content":"
We started by publishing journals and books from the fields of science we were most familiar with - AI, robotics, manufacturing and operations research. Through our growing network of institutions and authors, we soon expanded into related fields like environmental engineering, nanotechnology, computer science, renewable energy and electrical engineering, Today, we are the world’s largest Open Access publisher of scientific research, with over 4,200 books and 54,000 scientific works including peer-reviewed content from more than 116,000 scientists spanning 161 countries. Our authors range from globally-renowned Nobel Prize winners to up-and-coming researchers at the cutting edge of scientific discovery.
\\n\\n
In the same year that IntechOpen was founded, we launched what was at the time the first ever Open Access, peer-reviewed journal in its field: the International Journal of Advanced Robotic Systems (IJARS).
\\n\\n
The IntechOpen timeline
\\n\\n
2004
\\n\\n
\\n\\t
Intech Open is founded in Vienna, Austria, by Alex Lazinica and Vedran Kordic, two PhD students, and their first Open Access journals and books are published.
\\n\\t
Alex and Vedran launch the first Open Access, peer-reviewed robotics journal and IntechOpen’s flagship publication, the International Journal of Advanced Robotic Systems (IJARS).
\\n
\\n\\n
2005
\\n\\n
\\n\\t
IntechOpen publishes its first Open Access book: Cutting Edge Robotics.
\\n
\\n\\n
2006
\\n\\n
\\n\\t
IntechOpen publishes a special issue of IJARS, featuring contributions from NASA scientists regarding the Mars Exploration Rover missions.
\\n
\\n\\n
2008
\\n\\n
\\n\\t
Downloads milestone: 200,000 downloads reached
\\n
\\n\\n
2009
\\n\\n
\\n\\t
Publishing milestone: the first 100 Open Access STM books are published
\\n
\\n\\n
2010
\\n\\n
\\n\\t
Downloads milestone: one million downloads reached
\\n\\t
IntechOpen expands its book publishing into a new field: medicine.
\\n
\\n\\n
2011
\\n\\n
\\n\\t
Publishing milestone: More than five million downloads reached
\\n\\t
IntechOpen publishes 1996 Nobel Prize in Chemistry winner Harold W. Kroto’s “Strategies to Successfully Cross-Link Carbon Nanotubes”. Find it here.
\\n\\t
IntechOpen and TBI collaborate on a project to explore the changing needs of researchers and the evolving ways that they discover, publish and exchange information. The result is the survey “Author Attitudes Towards Open Access Publishing: A Market Research Program”.
\\n\\t
IntechOpen hosts SHOW - Share Open Access Worldwide; a series of lectures, debates, round-tables and events to bring people together in discussion of open source principles, intellectual property, content licensing innovations, remixed and shared culture and free knowledge.
\\n
\\n\\n
2012
\\n\\n
\\n\\t
Publishing milestone: 10 million downloads reached
\\n\\t
IntechOpen holds Interact2012, a free series of workshops held by figureheads of the scientific community including Professor Hiroshi Ishiguro, director of the Intelligent Robotics Laboratory, who took the audience through some of the most impressive human-robot interactions observed in his lab.
\\n
\\n\\n
2013
\\n\\n
\\n\\t
IntechOpen joins the Committee on Publication Ethics (COPE) as part of a commitment to guaranteeing the highest standards of publishing.
\\n
\\n\\n
2014
\\n\\n
\\n\\t
IntechOpen turns 10, with more than 30 million downloads to date.
\\n\\t
IntechOpen appoints its first Regional Representatives - members of the team situated around the world dedicated to increasing the visibility of our authors’ published work within their local scientific communities.
\\n
\\n\\n
2015
\\n\\n
\\n\\t
Downloads milestone: More than 70 million downloads reached, more than doubling since the previous year.
\\n\\t
Publishing milestone: IntechOpen publishes its 2,500th book and 40,000th Open Access chapter, reaching 20,000 citations in Thomson Reuters ISI Web of Science.
\\n\\t
40 IntechOpen authors are included in the top one per cent of the world’s most-cited researchers.
\\n\\t
Thomson Reuters’ ISI Web of Science Book Citation Index begins indexing IntechOpen’s books in its database.
\\n
\\n\\n
2016
\\n\\n
\\n\\t
IntechOpen is identified as a world leader in Simba Information’s Open Access Book Publishing 2016-2020 report and forecast. IntechOpen came in as the world’s largest Open Access book publisher by title count.
\\n
\\n\\n
2017
\\n\\n
\\n\\t
Downloads milestone: IntechOpen reaches more than 100 million downloads
\\n\\t
Publishing milestone: IntechOpen publishes its 3,000th Open Access book, making it the largest Open Access book collection in the world
We started by publishing journals and books from the fields of science we were most familiar with - AI, robotics, manufacturing and operations research. Through our growing network of institutions and authors, we soon expanded into related fields like environmental engineering, nanotechnology, computer science, renewable energy and electrical engineering, Today, we are the world’s largest Open Access publisher of scientific research, with over 4,200 books and 54,000 scientific works including peer-reviewed content from more than 116,000 scientists spanning 161 countries. Our authors range from globally-renowned Nobel Prize winners to up-and-coming researchers at the cutting edge of scientific discovery.
\n\n
In the same year that IntechOpen was founded, we launched what was at the time the first ever Open Access, peer-reviewed journal in its field: the International Journal of Advanced Robotic Systems (IJARS).
\n\n
The IntechOpen timeline
\n\n
2004
\n\n
\n\t
Intech Open is founded in Vienna, Austria, by Alex Lazinica and Vedran Kordic, two PhD students, and their first Open Access journals and books are published.
\n\t
Alex and Vedran launch the first Open Access, peer-reviewed robotics journal and IntechOpen’s flagship publication, the International Journal of Advanced Robotic Systems (IJARS).
\n
\n\n
2005
\n\n
\n\t
IntechOpen publishes its first Open Access book: Cutting Edge Robotics.
\n
\n\n
2006
\n\n
\n\t
IntechOpen publishes a special issue of IJARS, featuring contributions from NASA scientists regarding the Mars Exploration Rover missions.
\n
\n\n
2008
\n\n
\n\t
Downloads milestone: 200,000 downloads reached
\n
\n\n
2009
\n\n
\n\t
Publishing milestone: the first 100 Open Access STM books are published
\n
\n\n
2010
\n\n
\n\t
Downloads milestone: one million downloads reached
\n\t
IntechOpen expands its book publishing into a new field: medicine.
\n
\n\n
2011
\n\n
\n\t
Publishing milestone: More than five million downloads reached
\n\t
IntechOpen publishes 1996 Nobel Prize in Chemistry winner Harold W. Kroto’s “Strategies to Successfully Cross-Link Carbon Nanotubes”. Find it here.
\n\t
IntechOpen and TBI collaborate on a project to explore the changing needs of researchers and the evolving ways that they discover, publish and exchange information. The result is the survey “Author Attitudes Towards Open Access Publishing: A Market Research Program”.
\n\t
IntechOpen hosts SHOW - Share Open Access Worldwide; a series of lectures, debates, round-tables and events to bring people together in discussion of open source principles, intellectual property, content licensing innovations, remixed and shared culture and free knowledge.
\n
\n\n
2012
\n\n
\n\t
Publishing milestone: 10 million downloads reached
\n\t
IntechOpen holds Interact2012, a free series of workshops held by figureheads of the scientific community including Professor Hiroshi Ishiguro, director of the Intelligent Robotics Laboratory, who took the audience through some of the most impressive human-robot interactions observed in his lab.
\n
\n\n
2013
\n\n
\n\t
IntechOpen joins the Committee on Publication Ethics (COPE) as part of a commitment to guaranteeing the highest standards of publishing.
\n
\n\n
2014
\n\n
\n\t
IntechOpen turns 10, with more than 30 million downloads to date.
\n\t
IntechOpen appoints its first Regional Representatives - members of the team situated around the world dedicated to increasing the visibility of our authors’ published work within their local scientific communities.
\n
\n\n
2015
\n\n
\n\t
Downloads milestone: More than 70 million downloads reached, more than doubling since the previous year.
\n\t
Publishing milestone: IntechOpen publishes its 2,500th book and 40,000th Open Access chapter, reaching 20,000 citations in Thomson Reuters ISI Web of Science.
\n\t
40 IntechOpen authors are included in the top one per cent of the world’s most-cited researchers.
\n\t
Thomson Reuters’ ISI Web of Science Book Citation Index begins indexing IntechOpen’s books in its database.
\n
\n\n
2016
\n\n
\n\t
IntechOpen is identified as a world leader in Simba Information’s Open Access Book Publishing 2016-2020 report and forecast. IntechOpen came in as the world’s largest Open Access book publisher by title count.
\n
\n\n
2017
\n\n
\n\t
Downloads milestone: IntechOpen reaches more than 100 million downloads
\n\t
Publishing milestone: IntechOpen publishes its 3,000th Open Access book, making it the largest Open Access book collection in the world
\n
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His studies in robotics lead him not only to a PhD degree but also inspired him to co-found and build the International Journal of Advanced Robotic Systems - world's first Open Access journal in the field of robotics.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"441",title:"Ph.D.",name:"Jaekyu",middleName:null,surname:"Park",slug:"jaekyu-park",fullName:"Jaekyu Park",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/441/images/1881_n.jpg",biography:null,institutionString:null,institution:{name:"LG Corporation (South Korea)",country:{name:"Korea, South"}}},{id:"465",title:"Dr.",name:"Christian",middleName:null,surname:"Martens",slug:"christian-martens",fullName:"Christian Martens",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Rheinmetall (Germany)",country:{name:"Germany"}}},{id:"479",title:"Dr.",name:"Valentina",middleName:null,surname:"Colla",slug:"valentina-colla",fullName:"Valentina Colla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/479/images/358_n.jpg",biography:null,institutionString:null,institution:{name:"Sant'Anna School of Advanced Studies",country:{name:"Italy"}}},{id:"494",title:"PhD",name:"Loris",middleName:null,surname:"Nanni",slug:"loris-nanni",fullName:"Loris Nanni",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/494/images/system/494.jpg",biography:"Loris Nanni received his Master Degree cum laude on June-2002 from the University of Bologna, and the April 26th 2006 he received his Ph.D. in Computer Engineering at DEIS, University of Bologna. On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. His research interests include pattern recognition, bioinformatics, and biometric systems (fingerprint classification and recognition, signature verification, face recognition).",institutionString:null,institution:null},{id:"496",title:"Dr.",name:"Carlos",middleName:null,surname:"Leon",slug:"carlos-leon",fullName:"Carlos Leon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Seville",country:{name:"Spain"}}},{id:"512",title:"Dr.",name:"Dayang",middleName:null,surname:"Jawawi",slug:"dayang-jawawi",fullName:"Dayang Jawawi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Technology Malaysia",country:{name:"Malaysia"}}},{id:"528",title:"Dr.",name:"Kresimir",middleName:null,surname:"Delac",slug:"kresimir-delac",fullName:"Kresimir Delac",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/528/images/system/528.jpg",biography:"K. Delac received his B.Sc.E.E. degree in 2003 and is currentlypursuing a Ph.D. degree at the University of Zagreb, Faculty of Electrical Engineering andComputing. His current research interests are digital image analysis, pattern recognition andbiometrics.",institutionString:null,institution:{name:"University of Zagreb",country:{name:"Croatia"}}},{id:"557",title:"Dr.",name:"Andon",middleName:"Venelinov",surname:"Topalov",slug:"andon-topalov",fullName:"Andon Topalov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/557/images/1927_n.jpg",biography:"Dr. Andon V. Topalov received the MSc degree in Control Engineering from the Faculty of Information Systems, Technologies, and Automation at Moscow State University of Civil Engineering (MGGU) in 1979. He then received his PhD degree in Control Engineering from the Department of Automation and Remote Control at Moscow State Mining University (MGSU), Moscow, in 1984. From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. His current research interests are in the fields of intelligent control and robotics.",institutionString:null,institution:{name:"Technical University of Sofia",country:{name:"Bulgaria"}}},{id:"585",title:"Prof.",name:"Munir",middleName:null,surname:"Merdan",slug:"munir-merdan",fullName:"Munir Merdan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/585/images/system/585.jpg",biography:"Munir Merdan received the M.Sc. degree in mechanical engineering from the Technical University of Sarajevo, Bosnia and Herzegovina, in 2001, and the Ph.D. degree in electrical engineering from the Vienna University of Technology, Vienna, Austria, in 2009.Since 2005, he has been at the Automation and Control Institute, Vienna University of Technology, where he is currently a Senior Researcher. His research interests include the application of agent technology for achieving agile control in the manufacturing environment.",institutionString:null,institution:null},{id:"605",title:"Prof",name:"Dil",middleName:null,surname:"Hussain",slug:"dil-hussain",fullName:"Dil Hussain",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/605/images/system/605.jpg",biography:"Dr. Dil Muhammad Akbar Hussain is a professor of Electronics Engineering & Computer Science at the Department of Energy Technology, Aalborg University Denmark. Professor Akbar has a Master degree in Digital Electronics from Govt. College University, Lahore Pakistan and a P-hD degree in Control Engineering from the School of Engineering and Applied Sciences, University of Sussex United Kingdom. Aalborg University has Two Satellite Campuses, one in Copenhagen (Aalborg University Copenhagen) and the other in Esbjerg (Aalborg University Esbjerg).\n· He is a member of prestigious IEEE (Institute of Electrical and Electronics Engineers), and IAENG (International Association of Engineers) organizations. \n· He is the chief Editor of the Journal of Software Engineering.\n· He is the member of the Editorial Board of International Journal of Computer Science and Software Technology (IJCSST) and International Journal of Computer Engineering and Information Technology. \n· He is also the Editor of Communication in Computer and Information Science CCIS-20 by Springer.\n· Reviewer For Many Conferences\nHe is the lead person in making collaboration agreements between Aalborg University and many universities of Pakistan, for which the MOU’s (Memorandum of Understanding) have been signed.\nProfessor Akbar is working in Academia since 1990, he started his career as a Lab demonstrator/TA at the University of Sussex. After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. He has contributed in stochastic estimation of control area especially, in the Multiple Target Tracking and Interactive Multiple Model (IMM) research, Ball & Beam Control Problem, Robotics, Levitation Control. He has contributed in developing Algorithms for Fingerprint Matching, Computer Vision and Face Recognition. He has been supervising Pattern Recognition, Formal Languages and Distributed Processing projects for several years. He has reviewed many books on Management, Computer Science. Currently, he is an active and permanent reviewer for many international conferences and symposia and the program committee member for many international conferences.\nIn teaching he has taught the core computer science subjects like, Digital Design, Real Time Embedded System Programming, Operating Systems, Software Engineering, Data Structures, Databases, Compiler Construction. 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Küden"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},subject:{topic:{id:"1153",title:"Reproductive Surgery",slug:"reproductive-surgery",parent:{id:"202",title:"Surgery",slug:"surgery"},numberOfBooks:1,numberOfSeries:0,numberOfAuthorsAndEditors:17,numberOfWosCitations:0,numberOfCrossrefCitations:0,numberOfDimensionsCitations:1,videoUrl:null,fallbackUrl:null,description:null},booksByTopicFilter:{topicId:"1153",sort:"-publishedDate",limit:12,offset:0},booksByTopicCollection:[{type:"book",id:"5409",title:"Fertility-oriented Female Reproductive Surgery",subtitle:null,isOpenForSubmission:!1,hash:"1a01175c857cd700e350a0145e488e16",slug:"fertility-oriented-female-reproductive-surgery",bookSignature:"Atef Darwish",coverURL:"https://cdn.intechopen.com/books/images_new/5409.jpg",editedByType:"Edited by",editors:[{id:"29304",title:"Prof.",name:"Atef",middleName:"M.M.",surname:"Darwish",slug:"atef-darwish",fullName:"Atef Darwish"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],booksByTopicTotal:1,seriesByTopicCollection:[],seriesByTopicTotal:0,mostCitedChapters:[{id:"51944",doi:"10.5772/64861",title:"Hysteroscopic Surgery for Submucosal Fibroids",slug:"hysteroscopic-surgery-for-submucosal-fibroids",totalDownloads:17733,totalCrossrefCites:0,totalDimensionsCites:1,abstract:"This chapter presents a contemporary summary of the evidence of the clinical impact of submucosal fibroids and discusses the methods used to investigate and surgically manage this common gynaecological condition.",book:{id:"5409",slug:"fertility-oriented-female-reproductive-surgery",title:"Fertility-oriented Female Reproductive Surgery",fullTitle:"Fertility-oriented Female Reproductive Surgery"},signatures:"Rashi Kalra and Roger J Hart",authors:[{id:"187858",title:"Prof.",name:"Roger",middleName:null,surname:"Hart",slug:"roger-hart",fullName:"Roger Hart"},{id:"187861",title:"Dr.",name:"Rashi",middleName:null,surname:"Kalra",slug:"rashi-kalra",fullName:"Rashi Kalra"}]},{id:"52107",doi:"10.5772/64934",title:"Deep Neuromuscular Blockade Improves Surgical Conditions During Gynecological Laparoscopy",slug:"deep-neuromuscular-blockade-improves-surgical-conditions-during-gynecological-laparoscopy",totalDownloads:1514,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"Obtaining an appropriate laparoscopic workspace depends on several factors related to the patient (i.e., weight and abdominal compliance) and the procedure (i.e., body’s position, depth of anesthesia and intra-abdominal (IA) pressure). Among them, a deep neuromuscular blockade (NMB) contributes to provide the surgeon with better operating conditions. This chapter discusses the interests and challenges of muscle relaxation during gynecological laparoscopy. The introduction of sugammadex into clinical practice provides the opportunity to modify the management of neuromuscular blockade to improve the surgical conditions during laparoscopy as well as the safety of the patients. The maintenance of a rocuronium-induced deep neuromuscular block from the trocar insertion until the end of laparoscopy is no longer incompatible with rapid recovery and awakening in optimal conditions. Neuromuscular transmission (NMT) monitoring is the key to adequate management and should be used in all cases. Objective measurements allow for excellent intubation and surgical conditions, the definition of thresholds and doses for the administration of reversal agents, and the exclusion of residual blockade prior to the patient extubation.",book:{id:"5409",slug:"fertility-oriented-female-reproductive-surgery",title:"Fertility-oriented Female Reproductive Surgery",fullTitle:"Fertility-oriented Female Reproductive Surgery"},signatures:"Christophe Dransart, Laurie Putz, Maria-Laura Marotta and Philippe\nE. Dubois",authors:[{id:"164978",title:"Prof.",name:"Philippe",middleName:"E",surname:"Dubois",slug:"philippe-dubois",fullName:"Philippe Dubois"},{id:"194443",title:"Dr.",name:"Christophe",middleName:null,surname:"Dransart",slug:"christophe-dransart",fullName:"Christophe Dransart"},{id:"194444",title:"Dr.",name:"Laurie",middleName:null,surname:"Putz",slug:"laurie-putz",fullName:"Laurie Putz"},{id:"194445",title:"Dr.",name:"Maria-Laura",middleName:null,surname:"Marotta",slug:"maria-laura-marotta",fullName:"Maria-Laura Marotta"}]},{id:"52300",doi:"10.5772/65296",title:"Endometriosis: When and How We Treat",slug:"endometriosis-when-and-how-we-treat",totalDownloads:1374,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"Endometriosis is a chronic, nonmalignant and estrogen‐dependent disease in which endometrial glandular epithelium and stroma are outside the uterine cavity (ovaries, peritoneum, or rectovaginal septum). The prevalence is estimated from 2 to 10% in women of childbearing age and it rises up to 50% in women with infertility. Despite maximal efforts, the therapy of first choice in the management of endometriosis is still unclear. The aim of this chapter is to present an update of its management, emphasizing the benefits and disadvantages of surgical methods. We performed a systematic literature search on the PubMed database of English literature (search terms: endometrioma, surgery, ovarian reserve, assisted reproductive technologies) from 2010 to 2014. For endometrioma, operative laparoscopy proved to be the gold standard. Surgical procedures consist of partial excision of the cyst wall and electro‐coagulation of the rest. Stripping technique may be a better method for reducing the recurrence of pain symptoms, recurrence, and reoperation rates, but it raises concerns about ovarian reserve. For endometriosis, surgery often includes partial rectum or sacrouterine ligament resection. Hysterectomy is not obligatory and refused by the young patients. The approach should be laparoscopic and if necessary vaginal assisted. Good cooperation between various disciplines (gynecology, surgery, urology) is mandatory.",book:{id:"5409",slug:"fertility-oriented-female-reproductive-surgery",title:"Fertility-oriented Female Reproductive Surgery",fullTitle:"Fertility-oriented Female Reproductive Surgery"},signatures:"Sidonia Maria Saceanu, Stefan Patrascu, Anca Patrascu and Valeriu\nSurlin",authors:[{id:"158096",title:"Associate Prof.",name:"Valeriu",middleName:null,surname:"Surlin",slug:"valeriu-surlin",fullName:"Valeriu Surlin"},{id:"194539",title:"Dr.",name:"Stefan",middleName:null,surname:"Patrascu",slug:"stefan-patrascu",fullName:"Stefan Patrascu"},{id:"194540",title:"Dr.",name:"Sidonia Maria",middleName:null,surname:"Sandulescu",slug:"sidonia-maria-sandulescu",fullName:"Sidonia Maria Sandulescu"},{id:"194541",title:"Prof.",name:"Anca",middleName:null,surname:"Patrascu",slug:"anca-patrascu",fullName:"Anca Patrascu"}]},{id:"52615",doi:"10.5772/65769",title:"Bowel Dysfunction after Hysterectomy for Benign Conditions: Meta-Analysis and Systematic Review",slug:"bowel-dysfunction-after-hysterectomy-for-benign-conditions-meta-analysis-and-systematic-review",totalDownloads:1534,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"The aim of this study was to determine whether hysterectomy for a benign indication can cause functional gastrointestinal disorders (FGIDs). A systematic review was completed with the studies, which used a prospective design and validated quality of life questionnaires. A search strategy using Medline and Embase allowed the relevant studies published between 1950 and October 2010 to be found. Meta-analyses were also performed using the studies, which had similar research objectives. The search revealed 29 potentially suitable articles, of which 5 used a prospective design and validated quality of life questionnaires. The meta-analyses showed that the type of hysterectomy (total or subtotal) did not have an impact on whether a patient is likely to develop gastrointestinal symptoms post-surgery. The prospective studies did not show that hysterectomy for a benign indication causes FGIDs. The belief that hysterectomy can cause gastrointestinal dysfunction is based on the results of retrospective studies.",book:{id:"5409",slug:"fertility-oriented-female-reproductive-surgery",title:"Fertility-oriented Female Reproductive Surgery",fullTitle:"Fertility-oriented Female Reproductive Surgery"},signatures:"Constantina Pitsillides and Hany Lashen",authors:[{id:"191199",title:"Mr.",name:"Hany",middleName:null,surname:"Lashen",slug:"hany-lashen",fullName:"Hany Lashen"}]},{id:"52626",doi:"10.5772/65544",title:"Laparoscopic Surgery in the Treatment of Endometriosis",slug:"laparoscopic-surgery-in-the-treatment-of-endometriosis",totalDownloads:1385,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"Endometriosis is a benign disease, which affects about 10% of reproductive age women and almost 50% of infertile women. Although every year at least 300 new articles deal with this topic, endometriosis is still a enigmatic disease starting with theories of etiopathogenesis where there is still no consensus about the major cause of endometriosis. Also there is still no consensus about the management of the disease, mainly when there is an infertile patient who is preparing for in vitro fertilization procedure.",book:{id:"5409",slug:"fertility-oriented-female-reproductive-surgery",title:"Fertility-oriented Female Reproductive Surgery",fullTitle:"Fertility-oriented Female Reproductive Surgery"},signatures:"Sonja Pop-Trajkovic Dinic, Jasmina Popovic, Radomir Zivadinovic,\nDejan Mitic, Vladimir Antic and Milan Trenkic",authors:[{id:"69225",title:"Dr.",name:"Sonja",middleName:null,surname:"Pop-Trajkovic",slug:"sonja-pop-trajkovic",fullName:"Sonja Pop-Trajkovic"},{id:"194904",title:"Dr.",name:"Vladimir",middleName:null,surname:"Antic",slug:"vladimir-antic",fullName:"Vladimir Antic"},{id:"194905",title:"Prof.",name:"Jasmina",middleName:null,surname:"Popovic",slug:"jasmina-popovic",fullName:"Jasmina Popovic"},{id:"194906",title:"Dr.",name:"Milan",middleName:null,surname:"Trenkic",slug:"milan-trenkic",fullName:"Milan Trenkic"}]}],mostDownloadedChaptersLast30Days:[{id:"53784",title:"Microsurgical Cesarean Section",slug:"microsurgical-cesarean-section",totalDownloads:2355,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"Worldwide, not only is cesarean section (CS) the most commonly performed major surgery, but it is also the commonest obstetric operation. CD is associated with some chronic maternal morbidities including pelvic pain, adhesions and adverse reproductive effects. CS carries long‐term sequele which can adversely affect subsequent pregnancies. Why do some women develop bad sequele of CS‐like adhesions, and infertility is well demonstrated in this chapter. Fertility‐oriented step‐by‐step description of CS techniques is extensively described. Some recent controversial issues related to CS like the development of uterine nitche (isthmocele) at the CS scar site, placenta accrete and the role of cesarean myomectomy are discussed in details. At the end of this chapter, the reader will conceive enjoy fertility‐oriented concept of CS.",book:{id:"5409",slug:"fertility-oriented-female-reproductive-surgery",title:"Fertility-oriented Female Reproductive Surgery",fullTitle:"Fertility-oriented Female Reproductive Surgery"},signatures:"Atef Darwish",authors:[{id:"29304",title:"Prof.",name:"Atef",middleName:"M.M.",surname:"Darwish",slug:"atef-darwish",fullName:"Atef Darwish"}]},{id:"52615",title:"Bowel Dysfunction after Hysterectomy for Benign Conditions: Meta-Analysis and Systematic Review",slug:"bowel-dysfunction-after-hysterectomy-for-benign-conditions-meta-analysis-and-systematic-review",totalDownloads:1531,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"The aim of this study was to determine whether hysterectomy for a benign indication can cause functional gastrointestinal disorders (FGIDs). A systematic review was completed with the studies, which used a prospective design and validated quality of life questionnaires. A search strategy using Medline and Embase allowed the relevant studies published between 1950 and October 2010 to be found. Meta-analyses were also performed using the studies, which had similar research objectives. The search revealed 29 potentially suitable articles, of which 5 used a prospective design and validated quality of life questionnaires. The meta-analyses showed that the type of hysterectomy (total or subtotal) did not have an impact on whether a patient is likely to develop gastrointestinal symptoms post-surgery. The prospective studies did not show that hysterectomy for a benign indication causes FGIDs. The belief that hysterectomy can cause gastrointestinal dysfunction is based on the results of retrospective studies.",book:{id:"5409",slug:"fertility-oriented-female-reproductive-surgery",title:"Fertility-oriented Female Reproductive Surgery",fullTitle:"Fertility-oriented Female Reproductive Surgery"},signatures:"Constantina Pitsillides and Hany Lashen",authors:[{id:"191199",title:"Mr.",name:"Hany",middleName:null,surname:"Lashen",slug:"hany-lashen",fullName:"Hany Lashen"}]},{id:"51944",title:"Hysteroscopic Surgery for Submucosal Fibroids",slug:"hysteroscopic-surgery-for-submucosal-fibroids",totalDownloads:17730,totalCrossrefCites:0,totalDimensionsCites:1,abstract:"This chapter presents a contemporary summary of the evidence of the clinical impact of submucosal fibroids and discusses the methods used to investigate and surgically manage this common gynaecological condition.",book:{id:"5409",slug:"fertility-oriented-female-reproductive-surgery",title:"Fertility-oriented Female Reproductive Surgery",fullTitle:"Fertility-oriented Female Reproductive Surgery"},signatures:"Rashi Kalra and Roger J Hart",authors:[{id:"187858",title:"Prof.",name:"Roger",middleName:null,surname:"Hart",slug:"roger-hart",fullName:"Roger Hart"},{id:"187861",title:"Dr.",name:"Rashi",middleName:null,surname:"Kalra",slug:"rashi-kalra",fullName:"Rashi Kalra"}]},{id:"52626",title:"Laparoscopic Surgery in the Treatment of Endometriosis",slug:"laparoscopic-surgery-in-the-treatment-of-endometriosis",totalDownloads:1380,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"Endometriosis is a benign disease, which affects about 10% of reproductive age women and almost 50% of infertile women. Although every year at least 300 new articles deal with this topic, endometriosis is still a enigmatic disease starting with theories of etiopathogenesis where there is still no consensus about the major cause of endometriosis. Also there is still no consensus about the management of the disease, mainly when there is an infertile patient who is preparing for in vitro fertilization procedure.",book:{id:"5409",slug:"fertility-oriented-female-reproductive-surgery",title:"Fertility-oriented Female Reproductive Surgery",fullTitle:"Fertility-oriented Female Reproductive Surgery"},signatures:"Sonja Pop-Trajkovic Dinic, Jasmina Popovic, Radomir Zivadinovic,\nDejan Mitic, Vladimir Antic and Milan Trenkic",authors:[{id:"69225",title:"Dr.",name:"Sonja",middleName:null,surname:"Pop-Trajkovic",slug:"sonja-pop-trajkovic",fullName:"Sonja Pop-Trajkovic"},{id:"194904",title:"Dr.",name:"Vladimir",middleName:null,surname:"Antic",slug:"vladimir-antic",fullName:"Vladimir Antic"},{id:"194905",title:"Prof.",name:"Jasmina",middleName:null,surname:"Popovic",slug:"jasmina-popovic",fullName:"Jasmina Popovic"},{id:"194906",title:"Dr.",name:"Milan",middleName:null,surname:"Trenkic",slug:"milan-trenkic",fullName:"Milan Trenkic"}]},{id:"52107",title:"Deep Neuromuscular Blockade Improves Surgical Conditions During Gynecological Laparoscopy",slug:"deep-neuromuscular-blockade-improves-surgical-conditions-during-gynecological-laparoscopy",totalDownloads:1510,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"Obtaining an appropriate laparoscopic workspace depends on several factors related to the patient (i.e., weight and abdominal compliance) and the procedure (i.e., body’s position, depth of anesthesia and intra-abdominal (IA) pressure). 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Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Bacterial Infectious Diseases",value:3,count:2},{group:"subseries",caption:"Parasitic Infectious Diseases",value:5,count:4},{group:"subseries",caption:"Viral Infectious Diseases",value:6,count:7}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:2},{group:"publicationYear",caption:"2021",value:2021,count:4},{group:"publicationYear",caption:"2020",value:2020,count:3},{group:"publicationYear",caption:"2019",value:2019,count:3},{group:"publicationYear",caption:"2018",value:2018,count:1}],authors:{paginationCount:301,paginationItems:[{id:"116250",title:"Dr.",name:"Nima",middleName:null,surname:"Rezaei",slug:"nima-rezaei",fullName:"Nima Rezaei",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/116250/images/system/116250.jpg",biography:"Professor Nima Rezaei obtained an MD from Tehran University of Medical Sciences, Iran. He also obtained an MSc in Molecular and Genetic Medicine, and a Ph.D. in Clinical Immunology and Human Genetics from the University of Sheffield, UK. He also completed a short-term fellowship in Pediatric Clinical Immunology and Bone Marrow Transplantation at Newcastle General Hospital, England. Dr. Rezaei is a Full Professor of Immunology and Vice Dean of International Affairs and Research, at the School of Medicine, Tehran University of Medical Sciences, and the co-founder and head of the Research Center for Immunodeficiencies. He is also the founding president of the Universal Scientific Education and Research Network (USERN). Dr. Rezaei has directed more than 100 research projects and has designed and participated in several international collaborative projects. He is an editor, editorial assistant, or editorial board member of more than forty international journals. He has edited more than 50 international books, presented more than 500 lectures/posters in congresses/meetings, and published more than 1,100 scientific papers in international journals.",institutionString:"Tehran University of Medical Sciences",institution:{name:"Tehran University of Medical Sciences",country:{name:"Iran"}}},{id:"180733",title:"Dr.",name:"Jean",middleName:null,surname:"Engohang-Ndong",slug:"jean-engohang-ndong",fullName:"Jean Engohang-Ndong",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180733/images/system/180733.png",biography:"Dr. Jean Engohang-Ndong was born and raised in Gabon. After obtaining his Associate Degree of Science at the University of Science and Technology of Masuku, Gabon, he continued his education in France where he obtained his BS, MS, and Ph.D. in Medical Microbiology. He worked as a post-doctoral fellow at the Public Health Research Institute (PHRI), Newark, NJ for four years before accepting a three-year faculty position at Brigham Young University-Hawaii. Dr. Engohang-Ndong is a tenured faculty member with the academic rank of Full Professor at Kent State University, Ohio, where he teaches a wide range of biological science courses and pursues his research in medical and environmental microbiology. Recently, he expanded his research interest to epidemiology and biostatistics of chronic diseases in Gabon.",institutionString:"Kent State University",institution:{name:"Kent State University",country:{name:"United States of America"}}},{id:"188773",title:"Prof.",name:"Emmanuel",middleName:null,surname:"Drouet",slug:"emmanuel-drouet",fullName:"Emmanuel Drouet",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/188773/images/system/188773.png",biography:"Emmanuel Drouet, PharmD, is a Professor of Virology at the Faculty of Pharmacy, the University Grenoble-Alpes, France. As a head scientist at the Institute of Structural Biology in Grenoble, Dr. Drouet’s research investigates persisting viruses in humans (RNA and DNA viruses) and the balance with our host immune system. He focuses on these viruses’ effects on humans (both their impact on pathology and their symbiotic relationships in humans). He has an excellent track record in the herpesvirus field, and his group is engaged in clinical research in the field of Epstein-Barr virus diseases. He is the editor of the online Encyclopedia of Environment and he coordinates the Universal Health Coverage education program for the BioHealth Computing Schools of the European Institute of Science.",institutionString:null,institution:{name:"Grenoble Alpes University",country:{name:"France"}}},{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",biography:"Dr. Rodriguez-Morales is an expert in tropical and emerging diseases, particularly zoonotic and vector-borne diseases (especially arboviral diseases). He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},{id:"332819",title:"Dr.",name:"Chukwudi Michael",middleName:"Michael",surname:"Egbuche",slug:"chukwudi-michael-egbuche",fullName:"Chukwudi Michael Egbuche",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/332819/images/14624_n.jpg",biography:"I an Dr. Chukwudi Michael Egbuche. I am a Senior Lecturer in the Department of Parasitology and Entomology, Nnamdi Azikiwe University, Awka.",institutionString:null,institution:{name:"Nnamdi Azikiwe University",country:{name:"Nigeria"}}},{id:"284232",title:"Mr.",name:"Nikunj",middleName:"U",surname:"Tandel",slug:"nikunj-tandel",fullName:"Nikunj Tandel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/284232/images/8275_n.jpg",biography:'Mr. Nikunj Tandel has completed his Master\'s degree in Biotechnology from VIT University, India in the year of 2012. He is having 8 years of research experience especially in the field of malaria epidemiology, immunology, and nanoparticle-based drug delivery system against the infectious diseases, autoimmune disorders and cancer. He has worked for the NIH funded-International Center of Excellence in Malaria Research project "Center for the study of complex malaria in India (CSCMi)" in collaboration with New York University. The preliminary objectives of the study are to understand and develop the evidence-based tools and interventions for the control and prevention of malaria in different sites of the INDIA. Alongside, with the help of next-generation genomics study, the team has studied the antimalarial drug resistance in India. Further, he has extended his research in the development of Humanized mice for the study of liver-stage malaria and identification of molecular marker(s) for the Artemisinin resistance. At present, his research focuses on understanding the role of B cells in the activation of CD8+ T cells in malaria. Received the CSIR-SRF (Senior Research Fellow) award-2018, FIMSA (Federation of Immunological Societies of Asia-Oceania) Travel Bursary award to attend the IUIS-IIS-FIMSA Immunology course-2019',institutionString:"Nirma University",institution:{name:"Nirma University",country:{name:"India"}}},{id:"334383",title:"Ph.D.",name:"Simone",middleName:"Ulrich",surname:"Ulrich Picoli",slug:"simone-ulrich-picoli",fullName:"Simone Ulrich Picoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334383/images/15919_n.jpg",biography:"Graduated in Pharmacy from Universidade Luterana do Brasil (1999), Master in Agricultural and Environmental Microbiology from Federal University of Rio Grande do Sul (2002), Specialization in Clinical Microbiology from Universidade de São Paulo, USP (2007) and PhD in Sciences in Gastroenterology and Hepatology (2012). She is currently an Adjunct Professor at Feevale University in Medicine and Biomedicine courses and a permanent professor of the Academic Master\\'s Degree in Virology. She has experience in the field of Microbiology, with an emphasis on Bacteriology, working mainly on the following topics: bacteriophages, bacterial resistance, clinical microbiology and food microbiology.",institutionString:null,institution:{name:"Universidade Feevale",country:{name:"Brazil"}}},{id:"229220",title:"Dr.",name:"Amjad",middleName:"Islam",surname:"Aqib",slug:"amjad-aqib",fullName:"Amjad Aqib",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229220/images/system/229220.png",biography:"Dr. Amjad Islam Aqib obtained a DVM and MSc (Hons) from University of Agriculture Faisalabad (UAF), Pakistan, and a PhD from the University of Veterinary and Animal Sciences Lahore, Pakistan. Dr. Aqib joined the Department of Clinical Medicine and Surgery at UAF for one year as an assistant professor where he developed a research laboratory designated for pathogenic bacteria. Since 2018, he has been Assistant Professor/Officer in-charge, Department of Medicine, Manager Research Operations and Development-ORIC, and President One Health Club at Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan. He has nearly 100 publications to his credit. His research interests include epidemiological patterns and molecular analysis of antimicrobial resistance and modulation and vaccine development against animal pathogens of public health concern.",institutionString:"Cholistan University of Veterinary and Animal Sciences",institution:null},{id:"333753",title:"Dr.",name:"Rais",middleName:null,surname:"Ahmed",slug:"rais-ahmed",fullName:"Rais Ahmed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333753/images/20168_n.jpg",biography:null,institutionString:null,institution:{name:"University of Agriculture Faisalabad",country:{name:"Pakistan"}}},{id:"62900",title:"Prof.",name:"Fethi",middleName:null,surname:"Derbel",slug:"fethi-derbel",fullName:"Fethi Derbel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/62900/images/system/62900.jpeg",biography:"Professor Fethi Derbel was born in 1960 in Tunisia. He received his medical degree from the Sousse Faculty of Medicine at Sousse, University of Sousse, Tunisia. He completed his surgical residency in General Surgery at the University Hospital Farhat Hached of Sousse and was a member of the Unit of Liver Transplantation in the University of Rennes, France. He then worked in the Department of Surgery at the Sahloul University Hospital in Sousse. Professor Derbel is presently working at the Clinique les Oliviers, Sousse, Tunisia. His hospital activities are mostly concerned with laparoscopic, colorectal, pancreatic, hepatobiliary, and gastric surgery. He is also very interested in hernia surgery and performs ventral hernia repairs and inguinal hernia repairs. He has been a member of the GREPA and Tunisian Hernia Society (THS). During his residency, he managed patients suffering from diabetic foot, and he was very interested in this pathology. For this reason, he decided to coordinate a book project dealing with the diabetic foot. Professor Derbel has published many articles in journals and collaborates intensively with IntechOpen Access Publisher as an editor.",institutionString:"Clinique les Oliviers",institution:null},{id:"300144",title:"Dr.",name:"Meriem",middleName:null,surname:"Braiki",slug:"meriem-braiki",fullName:"Meriem Braiki",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/300144/images/system/300144.jpg",biography:"Dr. Meriem Braiki is a specialist in pediatric surgeon from Tunisia. She was born in 1985. She received her medical degree from the University of Medicine at Sousse, Tunisia. She achieved her surgical residency training periods in Pediatric Surgery departments at University Hospitals in Monastir, Tunis and France.\r\nShe is currently working at the Pediatric surgery department, Sidi Bouzid Hospital, Tunisia. Her hospital activities are mostly concerned with laparoscopic, parietal, urological and digestive surgery. She has published several articles in diffrent journals.",institutionString:"Sidi Bouzid Regional Hospital",institution:null},{id:"229481",title:"Dr.",name:"Erika M.",middleName:"Martins",surname:"de Carvalho",slug:"erika-m.-de-carvalho",fullName:"Erika M. de Carvalho",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229481/images/6397_n.jpg",biography:null,institutionString:null,institution:{name:"Oswaldo Cruz Foundation",country:{name:"Brazil"}}},{id:"186537",title:"Prof.",name:"Tonay",middleName:null,surname:"Inceboz",slug:"tonay-inceboz",fullName:"Tonay Inceboz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/186537/images/system/186537.jfif",biography:"I was graduated from Ege University of Medical Faculty (Turkey) in 1988 and completed his Med. PhD degree in Medical Parasitology at the same university. I became an Associate Professor in 2008 and Professor in 2014. I am currently working as a Professor at the Department of Medical Parasitology at Dokuz Eylul University, Izmir, Turkey.\n\nI have given many lectures, presentations in different academic meetings. I have more than 60 articles in peer-reviewed journals, 18 book chapters, 1 book editorship.\n\nMy research interests are Echinococcus granulosus, Echinococcus multilocularis (diagnosis, life cycle, in vitro and in vivo cultivation), and Trichomonas vaginalis (diagnosis, PCR, and in vitro cultivation).",institutionString:"Dokuz Eylül University",institution:{name:"Dokuz Eylül University",country:{name:"Turkey"}}},{id:"71812",title:"Prof.",name:"Hanem Fathy",middleName:"Fathy",surname:"Khater",slug:"hanem-fathy-khater",fullName:"Hanem Fathy Khater",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/71812/images/1167_n.jpg",biography:"Prof. Khater is a Professor of Parasitology at Benha University, Egypt. She studied for her doctoral degree, at the Department of Entomology, College of Agriculture, Food and Natural Resources, University of Missouri, Columbia, USA. She has completed her Ph.D. degrees in Parasitology in Egypt, from where she got the award for “the best scientific Ph.D. dissertation”. She worked at the School of Biological Sciences, Bristol, England, the UK in controlling insects of medical and veterinary importance as a grant from Newton Mosharafa, the British Council. Her research is focused on searching of pesticides against mosquitoes, house flies, lice, green bottle fly, camel nasal botfly, soft and hard ticks, mites, and the diamondback moth as well as control of several parasites using safe and natural materials to avoid drug resistances and environmental contamination.",institutionString:null,institution:{name:"Banha University",country:{name:"Egypt"}}},{id:"99780",title:"Prof.",name:"Omolade",middleName:"Olayinka",surname:"Okwa",slug:"omolade-okwa",fullName:"Omolade Okwa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/99780/images/system/99780.jpg",biography:"Omolade Olayinka Okwa is presently a Professor of Parasitology at Lagos State University, Nigeria. She has a PhD in Parasitology (1997), an MSc in Cellular Parasitology (1992), and a BSc (Hons) Zoology (1990) all from the University of Ibadan, Nigeria. She teaches parasitology at the undergraduate and postgraduate levels. She was a recipient of a Commonwealth fellowship supported by British Council tenable at the Centre for Entomology and Parasitology (CAEP), Keele University, United Kingdom between 2004 and 2005. She was awarded an Honorary Visiting Research Fellow at the same university from 2005 to 2007. \nShe has been an external examiner to the Department of Veterinary Microbiology and Parasitology, University of Ibadan, MSc programme between 2010 and 2012. She is a member of the Nigerian Society of Experimental Biology (NISEB), Parasitology and Public Health Society of Nigeria (PPSN), Science Association of Nigeria (SAN), Zoological Society of Nigeria (ZSN), and is Vice Chairperson of the Organisation of Women in Science (OWSG), LASU chapter. She served as Head of Department of Zoology and Environmental Biology, Lagos State University from 2007 to 2010 and 2014 to 2016. She is a reviewer for several local and international journals such as Unilag Journal of Science, Libyan Journal of Medicine, Journal of Medicine and Medical Sciences, and Annual Research and Review in Science. \nShe has authored 45 scientific research publications in local and international journals, 8 scientific reviews, 4 books, and 3 book chapters, which includes the books “Malaria Parasites” and “Malaria” which are IntechOpen access publications.",institutionString:"Lagos State University",institution:{name:"Lagos State University",country:{name:"Nigeria"}}},{id:"273100",title:"Dr.",name:"Vijay",middleName:null,surname:"Gayam",slug:"vijay-gayam",fullName:"Vijay Gayam",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/273100/images/system/273100.jpeg",biography:"Dr. Vijay Bhaskar Reddy Gayam is currently practicing as an internist at Interfaith Medical Center in Brooklyn, New York, USA. He is also a Clinical Assistant Professor at the SUNY Downstate University Hospital and Adjunct Professor of Medicine at the American University of Antigua. He is a holder of an M.B.B.S. degree bestowed to him by Osmania Medical College and received his M.D. at Interfaith Medical Center. His career goals thus far have heavily focused on direct patient care, medical education, and clinical research. He currently serves in two leadership capacities; Assistant Program Director of Medicine at Interfaith Medical Center and as a Councilor for the American\r\nFederation for Medical Research. As a true academician and researcher, he has more than 50 papers indexed in international peer-reviewed journals. He has also presented numerous papers in multiple national and international scientific conferences. His areas of research interest include general internal medicine, gastroenterology and hepatology. He serves as an editor, editorial board member and reviewer for multiple international journals. His research on Hepatitis C has been very successful and has led to multiple research awards, including the 'Equity in Prevention and Treatment Award” from the New York Department of Health Viral Hepatitis Symposium (2018) and the 'Presidential Poster Award” awarded to him by the American College of Gastroenterology (2018). He was also awarded 'Outstanding Clinician in General Medicine” by Venus International Foundation for his extensive research expertise and services, perform over and above the standard expected in the advancement of healthcare, patient safety and quality of care.",institutionString:"Interfaith Medical Center",institution:{name:"Interfaith Medical Center",country:{name:"United States of America"}}},{id:"93517",title:"Dr.",name:"Clement",middleName:"Adebajo",surname:"Meseko",slug:"clement-meseko",fullName:"Clement Meseko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/93517/images/system/93517.jpg",biography:"Dr. Clement Meseko obtained DVM and PhD degree in Veterinary Medicine and Virology respectively. He has worked for over 20 years in both private and public sectors including the academia, contributing to knowledge and control of infectious disease. Through the application of epidemiological skill, classical and molecular virological skills, he investigates viruses of economic and public health importance for the mitigation of the negative impact on people, animal and the environment in the context of Onehealth. \r\nDr. Meseko’s field experience on animal and zoonotic diseases and pathogen dynamics at the human-animal interface over the years shaped his carrier in research and scientific inquiries. He has been part of the investigation of Highly Pathogenic Avian Influenza incursions in sub Saharan Africa and monitors swine Influenza (Pandemic influenza Virus) agro-ecology and potential for interspecies transmission. He has authored and reviewed a number of journal articles and book chapters.",institutionString:"National Veterinary Research Institute",institution:{name:"National Veterinary Research Institute",country:{name:"Nigeria"}}},{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",country:{name:"India"}}},{id:"94928",title:"Dr.",name:"Takuo",middleName:null,surname:"Mizukami",slug:"takuo-mizukami",fullName:"Takuo Mizukami",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94928/images/6402_n.jpg",biography:null,institutionString:null,institution:{name:"National Institute of Infectious Diseases",country:{name:"Japan"}}},{id:"233433",title:"Dr.",name:"Yulia",middleName:null,surname:"Desheva",slug:"yulia-desheva",fullName:"Yulia Desheva",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/233433/images/system/233433.png",biography:"Dr. Yulia Desheva is a leading researcher at the Institute of Experimental Medicine, St. Petersburg, Russia. She is a professor in the Stomatology Faculty, St. Petersburg State University. She has expertise in the development and evaluation of a wide range of live mucosal vaccines against influenza and bacterial complications. Her research interests include immunity against influenza and COVID-19 and the development of immunization schemes for high-risk individuals.",institutionString:'Federal State Budgetary Scientific Institution "Institute of Experimental Medicine"',institution:null},{id:"238958",title:"Mr.",name:"Atamjit",middleName:null,surname:"Singh",slug:"atamjit-singh",fullName:"Atamjit Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/238958/images/6575_n.jpg",biography:null,institutionString:null,institution:null},{id:"252058",title:"M.Sc.",name:"Juan",middleName:null,surname:"Sulca",slug:"juan-sulca",fullName:"Juan Sulca",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252058/images/12834_n.jpg",biography:null,institutionString:null,institution:null},{id:"191392",title:"Dr.",name:"Marimuthu",middleName:null,surname:"Govindarajan",slug:"marimuthu-govindarajan",fullName:"Marimuthu Govindarajan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/191392/images/5828_n.jpg",biography:"Dr. M. 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He serves as an editorial board member in various national and international scientific journals.",institutionString:null,institution:null},{id:"274660",title:"Dr.",name:"Damodar",middleName:null,surname:"Paudel",slug:"damodar-paudel",fullName:"Damodar Paudel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/274660/images/8176_n.jpg",biography:"I am DrDamodar Paudel,currently working as consultant Physician in Nepal police Hospital.",institutionString:null,institution:null},{id:"241562",title:"Dr.",name:"Melvin",middleName:null,surname:"Sanicas",slug:"melvin-sanicas",fullName:"Melvin Sanicas",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/241562/images/6699_n.jpg",biography:null,institutionString:null,institution:null},{id:"322007",title:"Dr.",name:"Maria Elizbeth",middleName:null,surname:"Alvarez-Sánchez",slug:"maria-elizbeth-alvarez-sanchez",fullName:"Maria Elizbeth Alvarez-Sánchez",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universidad Autónoma de la Ciudad de México",country:{name:"Mexico"}}},{id:"337446",title:"Dr.",name:"Maria",middleName:null,surname:"Zavala-Colon",slug:"maria-zavala-colon",fullName:"Maria Zavala-Colon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Puerto Rico, Medical Sciences Campus",country:{name:"United States of America"}}},{id:"338856",title:"Mrs.",name:"Nur Alvira",middleName:null,surname:"Pascawati",slug:"nur-alvira-pascawati",fullName:"Nur Alvira Pascawati",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universitas Respati Yogyakarta",country:{name:"Indonesia"}}},{id:"441116",title:"Dr.",name:"Jovanka M.",middleName:null,surname:"Voyich",slug:"jovanka-m.-voyich",fullName:"Jovanka M. 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Novel computational algorithms for image analysis, scene understanding, biometrics, deep learning and their software or hardware implementations for natural and medical images, robotics, VR/AR, applications are some research directions relevant to this topic.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/24.jpg",hasOnlineFirst:!0,hasPublishedBooks:!1,annualVolume:11420,editor:{id:"294154",title:"Prof.",name:"George",middleName:null,surname:"Papakostas",slug:"george-papakostas",fullName:"George Papakostas",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002hYaGbQAK/Profile_Picture_1624519712088",biography:"George A. Papakostas has received a diploma in Electrical and Computer Engineering in 1999 and the M.Sc. and Ph.D. degrees in Electrical and Computer Engineering in 2002 and 2007, respectively, from the Democritus University of Thrace (DUTH), Greece. Dr. Papakostas serves as a Tenured Full Professor at the Department of Computer Science, International Hellenic University, Greece. Dr. Papakostas has 10 years of experience in large-scale systems design as a senior software engineer and technical manager, and 20 years of research experience in the field of Artificial Intelligence. Currently, he is the Head of the “Visual Computing” division of HUman-MAchines INteraction Laboratory (HUMAIN-Lab) and the Director of the MPhil program “Advanced Technologies in Informatics and Computers” hosted by the Department of Computer Science, International Hellenic University. He has (co)authored more than 150 publications in indexed journals, international conferences and book chapters, 1 book (in Greek), 3 edited books, and 5 journal special issues. His publications have more than 2100 citations with h-index 27 (GoogleScholar). His research interests include computer/machine vision, machine learning, pattern recognition, computational intelligence. \nDr. Papakostas served as a reviewer in numerous journals, as a program\ncommittee member in international conferences and he is a member of the IAENG, MIR Labs, EUCogIII, INSTICC and the Technical Chamber of Greece (TEE).",institutionString:null,institution:{name:"International Hellenic University",institutionURL:null,country:{name:"Greece"}}},editorTwo:null,editorThree:null,series:{id:"14",title:"Artificial Intelligence",doi:"10.5772/intechopen.79920",issn:"2633-1403"},editorialBoard:[{id:"1177",title:"Prof.",name:"António",middleName:"J. 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