\\n\\n
Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\\n\\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\\n"}]',published:!0,mainMedia:{caption:"Highly Cited",originalUrl:"/media/original/117"}},components:[{type:"htmlEditorComponent",content:'IntechOpen is proud to announce that 191 of our authors have made the Clarivate™ Highly Cited Researchers List for 2020, ranking them among the top 1% most-cited.
\n\nThroughout the years, the list has named a total of 261 IntechOpen authors as Highly Cited. Of those researchers, 69 have been featured on the list multiple times.
\n\n\n\nReleased this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\n\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\n'}],latestNews:[{slug:"intechopen-supports-asapbio-s-new-initiative-publish-your-reviews-20220729",title:"IntechOpen Supports ASAPbio’s New Initiative Publish Your Reviews"},{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"}]},book:{item:{type:"book",id:"6970",leadTitle:null,fullTitle:"The Universe of Escherichia coli",title:"The Universe of Escherichia coli",subtitle:null,reviewType:"peer-reviewed",abstract:'The title of the book "The Universe of Escherichia coli" aims to present and emphasize the huge diversity of this bacterial species and our efforts to prevent the E. coli infections. As it is part of the gut microbiota, E. coli is a well-known commensal species, and probiotic E. coli strains are successfully used for improving host\'s health. Also many "workhorse" E. coli strain exist that are employed in laboratory and biotechnology settings. But certain E. coli strains can cause intestinal and also extraintestinal infections at many anatomical sites. Therefore many efforts are undertaken to prevent E. coli infections, among them food safety, vaccines, but also new antimicrobial agents are searched for.',isbn:"978-1-83881-153-2",printIsbn:"978-1-83881-152-5",pdfIsbn:"978-1-83881-154-9",doi:"10.5772/intechopen.73717",price:119,priceEur:129,priceUsd:155,slug:"the-universe-of-escherichia-coli",numberOfPages:148,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"92027ca0bca1f8ae2971739a4ae6af84",bookSignature:"Marjanca Starčič Erjavec",publishedDate:"September 18th 2019",coverURL:"https://cdn.intechopen.com/books/images_new/6970.jpg",numberOfDownloads:7331,numberOfWosCitations:9,numberOfCrossrefCitations:13,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:17,numberOfDimensionsCitationsByBook:1,hasAltmetrics:0,numberOfTotalCitations:39,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"July 2nd 2018",dateEndSecondStepPublish:"July 23rd 2018",dateEndThirdStepPublish:"September 21st 2018",dateEndFourthStepPublish:"December 10th 2018",dateEndFifthStepPublish:"February 8th 2019",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"58980",title:"Dr.",name:"Marjanca",middleName:null,surname:"Starčič Erjavec",slug:"marjanca-starcic-erjavec",fullName:"Marjanca Starčič Erjavec",profilePictureURL:"https://mts.intechopen.com/storage/users/58980/images/system/58980.jpeg",biography:"Marjanca Starčič Erjavec, PhD, is a professor of Molecular Biology at the Department of Biology, Biotechnical faculty, University of Ljubljana, Slovenia, EU. She studied biology (undergraduate course) and biochemistry and molecular biology (graduate course) at the University of Ljubljana, Slovenia. She defended her PhD thesis in the field of bacterial molecular genetics at the University of Utrecht, Netherlands. She was a visiting professor at University of Maribor, Slovenia, University of Graz, Austria, University of Modena, Italy, Duke University, Durham, USA and at the Institute of Ecology and Genetics of Microorganisms, Perm, Russia. At the University of Ljubljana, she is involved in teaching different subjects for students of microbiology and molecular and functional biology. She conducts research on horizontal gene transfer, including plasmids, natural and clinical E. coli strains.",institutionString:"University of Ljubljana",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"3",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"University of Ljubljana",institutionURL:null,country:{name:"Slovenia"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"409",title:"Bacteriology",slug:"biochemistry-genetics-and-molecular-biology-microbiology-bacteriology"}],chapters:[{id:"68841",title:"Introductory Chapter: The Versatile Escherichia coli",doi:"10.5772/intechopen.88882",slug:"introductory-chapter-the-versatile-em-escherichia-coli-em-",totalDownloads:1080,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Marjanca Starčič Erjavec",downloadPdfUrl:"/chapter/pdf-download/68841",previewPdfUrl:"/chapter/pdf-preview/68841",authors:[{id:"58980",title:"Dr.",name:"Marjanca",surname:"Starčič Erjavec",slug:"marjanca-starcic-erjavec",fullName:"Marjanca Starčič Erjavec"}],corrections:null},{id:"64755",title:"Escherichia coli: A Versatile Platform for Recombinant Protein Expression",doi:"10.5772/intechopen.82276",slug:"-em-escherichia-coli-em-a-versatile-platform-for-recombinant-protein-expression",totalDownloads:919,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Among the living organisms, Escherichia coli has been the most common choice employed for recombinant protein expression. In addition to its well-characterized genetics, E. coli is fast growing, relatively cheap, and easy to handle. These fine properties, in conjunction with the success achieved in transforming plasmid DNA into E. coli, as well as the advent of various genetic engineering techniques in the 1970s, have enabled E. coli to be considered as the most favorable host for genetic manipulations. The recent advances in better comprehension of regulatory controls of gene expression and the availability of various novel approaches, which include both intracellular, e.g., through intein-mediated expression and self-cleavages, and extracellular, e.g., through the use of secretion signals, to achieve successful expression of the target proteins in E. coli further support the view that E. coli is the most promising host choice for heterologous protein expression.",signatures:"Wan-Keung Raymond Wong, Ka-Lun Ng, Thiyagarajan Sivakumar, Xiu-Hua Hu, Hao Wang and Lai-Cheuk Nelson Lai",downloadPdfUrl:"/chapter/pdf-download/64755",previewPdfUrl:"/chapter/pdf-preview/64755",authors:[{id:"269357",title:"Prof.",name:"Wan Keung Raymond",surname:"Wong",slug:"wan-keung-raymond-wong",fullName:"Wan Keung Raymond Wong"}],corrections:null},{id:"68887",title:"Enteropathogenic Escherichia coli",doi:"10.5772/intechopen.82861",slug:"enteropathogenic-em-escherichia-coli-em-",totalDownloads:779,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The term enteropathogenic Escherichia coli (EPEC) was first used in 1955 to describe a number of serogroup-defined E. coli strains associated with infantile diarrhea. EPEC are now defined as those that produce a characteristic intestinal histopathology known as attaching and effacing (A/E) and do not produce Shiga toxins. EPEC carry the locus for enterocyte effacement (LEE) pathogenicity island, which contains the eae gene that encodes an outer membrane protein called intimin. Typical EPEC (tEPEC) carry a virulence plasmid known as the pEAF (EPEC adhesion factor plasmid) which encodes the bundle-forming pilus (BFP) that mediate localized adherence to epithelial cells, whereas atypical EPEC (aEPEC) do not possess this plasmid. Typical EPEC strains have been associated with severe outbreaks of infant diarrhea in developing countries. Atypical EPEC strains have been linked to diarrhea outbreaks at all ages worldwide. Diarrhea due to aEPEC in children is not as severe as that caused by tEPEC.",signatures:"Isabel Cristina Affonso Scaletsky",downloadPdfUrl:"/chapter/pdf-download/68887",previewPdfUrl:"/chapter/pdf-preview/68887",authors:[{id:"269031",title:"Associate Prof.",name:"Isabel",surname:"Scaletsky",slug:"isabel-scaletsky",fullName:"Isabel Scaletsky"}],corrections:null},{id:"65564",title:"Insight into the mobilome of Escherichia coli",doi:"10.5772/intechopen.82799",slug:"insight-into-the-mobilome-of-em-escherichia-coli-em-",totalDownloads:807,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:1,abstract:"Mobilomes are all mobile genetic elements (plasmids, transposable elements, insertion sequences, gene cassettes, integrons, genomic islands, and bacteriophages) in a genome. Mobilome is one of the responsible agents for the bacterial evolution, virulence, and increasing antibiotic resistance. The mobile genetic elements in the Escherichia coli genome can carry antibiotic resistance genes and/or virulence genes. The acquisition of new mobile genetic elements can lead to the emergence of new pathotypes. The aim of this chapter is to gather knowledge about mobile genetic elements in E. coli strains. The method in this chapter depends on a literature survey, which scans reviews, research articles, and theses published about transposable elements, plasmids, bacteriophages, and genomic islands in E. coli strains.",signatures:"Elif Bozcal",downloadPdfUrl:"/chapter/pdf-download/65564",previewPdfUrl:"/chapter/pdf-preview/65564",authors:[{id:"203449",title:"Ph.D.",name:"Elif",surname:"Bozcal",slug:"elif-bozcal",fullName:"Elif Bozcal"}],corrections:null},{id:"65498",title:"Escherichia coli and Food Safety",doi:"10.5772/intechopen.82375",slug:"-em-escherichia-coli-em-and-food-safety",totalDownloads:1869,totalCrossrefCites:11,totalDimensionsCites:16,hasAltmetrics:0,abstract:"Foodborne pathogens are evaluated as an important risk factor in terms of public health in developed and developing countries due to their extensiveness all around the world. Escherichia coli and other coliform bacteria are important foodborne pathogens. Some of the most important sources of contamination for these groups of microorganisms are reported as: areas with unfavorable hygiene, contaminated waste water, meat products, cereal products and vegetables. Total coliform bacteria and E. coli count is known to be the indicator of unfavorable hygienic conditions and fecal contamination in foods. Foodborne diseases, however, are a global issue. A joint approach by all countries and related international organizations is a prerequisite for detection and control of foodborne problems that pose a threat to human health and international trade. Despite their complicated biology, epidemiology and analyses, most foodborne diseases are preventable. It is of vital importance for public health that consumers and food producers act in accordance with the principles regarding internationally accepted safety methods.",signatures:"Gözde Ekici and Emek Dümen",downloadPdfUrl:"/chapter/pdf-download/65498",previewPdfUrl:"/chapter/pdf-preview/65498",authors:[{id:"269684",title:"M.Sc.",name:"Gözde",surname:"Ekici",slug:"gozde-ekici",fullName:"Gözde Ekici"},{id:"269686",title:"Dr.",name:"Emek",surname:"Dümen",slug:"emek-dumen",fullName:"Emek Dümen"}],corrections:null},{id:"65326",title:"Human and Veterinary Vaccines against Pathogenic Escherichia coli",doi:"10.5772/intechopen.82835",slug:"human-and-veterinary-vaccines-against-pathogenic-em-escherichia-coli-em-",totalDownloads:1090,totalCrossrefCites:1,totalDimensionsCites:0,hasAltmetrics:0,abstract:"PathogenicEscherichia coli constitute an important current problem of public health and animal production. Efforts have been made to fight the infections caused by these bacteria, and in this chapter, we present the progress made up to date in the vaccines generated for this purpose. Different vaccines have been tested against the pathotypes responsible for human diseases such as diarrhea and urinary infections. Also, the poultry market has deserved the effort of the researchers to obtain a product that fights the E. coli strains that cause diseases in them. Finally, advances are also presented for the zoonotic enterohemorrhagic E. coli (EHEC), which are a different problem due to their low importance as a disease factor in cattle, but they are a very important pathogen in humans. In several of these fields, authorized products have been developed and are currently being marketed.",signatures:"Mariano Larzábal, Angel A. Cataldi and Daniel A. Vilte",downloadPdfUrl:"/chapter/pdf-download/65326",previewPdfUrl:"/chapter/pdf-preview/65326",authors:[{id:"269584",title:"Dr.",name:"Angel Adrian",surname:"Cataldi",slug:"angel-adrian-cataldi",fullName:"Angel Adrian Cataldi"},{id:"269585",title:"Dr.",name:"Mariano",surname:"Larzabal",slug:"mariano-larzabal",fullName:"Mariano Larzabal"}],corrections:null},{id:"64955",title:"Photodynamic Inactivation of Escherichia coli with Cationic Porphyrin Sensitizers",doi:"10.5772/intechopen.82645",slug:"photodynamic-inactivation-of-em-escherichia-coli-em-with-cationic-porphyrin-sensitizers",totalDownloads:790,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"The activity of singlet-oxygen sensitizers for photodynamic inactivation (PDI) of microorganisms and photodynamic therapy of tumor cells has been evaluated using Escherichia coli, Saccharomyces cerevisiae, and human cancer cell lines. In this chapter, drug resistance of E. coli was examined based on the PDI activity of a variety of RPy-P-porphyrin sensitizers with different number of ionic valence and different hydrophobic characters. The PDI activities toward E. coli were evaluated using the minimum effective concentrations ([P]) of the porphyrin sensitizers. It was found that the [P] value for E. coli was larger than that for S. cerevisiae. E. coli has drug-resistance toward hydrophobic and mono-cationic porphyrins. However, E. coli has weak drug-resistance toward the porphyrins with both polycationic character and hydrophobicity. Since the outer membrane mainly consists of lipopolysaccharides and phospholipids that are negatively charged, cationic porphyrins are able to adsorb to the outer leaflet. Then the cationic porphyrins with hydrophobic character can interact with not only the outer leaflet but also inner leaflet of the outer membrane and the plasma membrane. Thus, porphyrins may be incorporated inside E. coli cells via the self-promoted uptake pathway. Moreover, polycationic porphyrins can interact with DNA and proteins by strong binding affinities.",signatures:"Jin Matsumoto, Tomoko Matsumoto, Kazuya Yasuda and Masahide Yasuda",downloadPdfUrl:"/chapter/pdf-download/64955",previewPdfUrl:"/chapter/pdf-preview/64955",authors:[{id:"153619",title:"Emeritus Prof.",name:"Masahide",surname:"Yasuda",slug:"masahide-yasuda",fullName:"Masahide Yasuda"},{id:"208528",title:"Prof.",name:"Jin",surname:"Matsumoto",slug:"jin-matsumoto",fullName:"Jin Matsumoto"},{id:"269599",title:"Dr.",name:"Tomoko",surname:"Matsumoto",slug:"tomoko-matsumoto",fullName:"Tomoko Matsumoto"},{id:"271672",title:"Dr.",name:"Kazuya",surname:"Yasuda",slug:"kazuya-yasuda",fullName:"Kazuya Yasuda"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"2796",title:"Lactic Acid Bacteria",subtitle:"R & D for Food, Health and Livestock Purposes",isOpenForSubmission:!1,hash:"8d625f084ccba1e96cc326406074fe3f",slug:"lactic-acid-bacteria-r-d-for-food-health-and-livestock-purposes",bookSignature:"Marcelino Kongo",coverURL:"https://cdn.intechopen.com/books/images_new/2796.jpg",editedByType:"Edited by",editors:[{id:"138356",title:"Dr.",name:"J. Marcelino",surname:"Kongo",slug:"j.-marcelino-kongo",fullName:"J. Marcelino Kongo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5056",title:"Actinobacteria",subtitle:"Basics and Biotechnological Applications",isOpenForSubmission:!1,hash:"46638f9636540f83f06226bf0e0a1e43",slug:"actinobacteria-basics-and-biotechnological-applications",bookSignature:"Dharumadurai Dhanasekaran and Yi Jiang",coverURL:"https://cdn.intechopen.com/books/images_new/5056.jpg",editedByType:"Edited by",editors:[{id:"48914",title:"Dr.",name:"Dharumadurai",surname:"Dhanasekaran",slug:"dharumadurai-dhanasekaran",fullName:"Dharumadurai Dhanasekaran"}],equalEditorOne:{id:"200541",title:"Dr.",name:"Yi",middleName:null,surname:"Jiang",slug:"yi-jiang",fullName:"Yi Jiang",profilePictureURL:"https://mts.intechopen.com/storage/users/200541/images/system/200541.png",biography:"Dr. Yi Jiang, PhD of Kiel University, Germany; and Associate Professor of Yunnan Institute of Microbiology, Yunnan University. She is a specialist in taxonomy, ecology and resources of actinomycetes. Dr. Yiang published 93 academic articles and 3 books, obtained 9 patents, and awarded a first prize of Natural Science of Yunnan and Second prize of Kunming City.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:null},equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2129",title:"A Search for Antibacterial Agents",subtitle:null,isOpenForSubmission:!1,hash:"1567c6402f459b018a6aabfd620aa3f7",slug:"a-search-for-antibacterial-agents",bookSignature:"Varaprasad Bobbarala",coverURL:"https://cdn.intechopen.com/books/images_new/2129.jpg",editedByType:"Edited by",editors:[{id:"90574",title:"Dr.",name:"Varaprasad",surname:"Bobbarala",slug:"varaprasad-bobbarala",fullName:"Varaprasad Bobbarala"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5867",title:"Antibacterial Agents",subtitle:null,isOpenForSubmission:!1,hash:"7834e622de76478416bdc3092c52cb15",slug:"antibacterial-agents",bookSignature:"Ranjith N. Kumavath",coverURL:"https://cdn.intechopen.com/books/images_new/5867.jpg",editedByType:"Edited by",editors:[{id:"163692",title:"Dr.",name:"Ranjith",surname:"Kumavath",slug:"ranjith-kumavath",fullName:"Ranjith Kumavath"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6148",title:"Bacterial Pathogenesis and Antibacterial Control",subtitle:null,isOpenForSubmission:!1,hash:"92128a5094670f6b0c9321640f60d3a3",slug:"bacterial-pathogenesis-and-antibacterial-control",bookSignature:"Sahra",coverURL:"https://cdn.intechopen.com/books/images_new/6148.jpg",editedByType:"Edited by",editors:[{id:"179460",title:"Associate Prof.",name:"Sahra",surname:"Kırmusaoğlu",slug:"sahra-kirmusaoglu",fullName:"Sahra Kırmusaoğlu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6764",title:"Cyanobacteria",subtitle:null,isOpenForSubmission:!1,hash:"87c7d8f86f7c1185aa4dd47c6492951a",slug:"cyanobacteria",bookSignature:"Archana Tiwari",coverURL:"https://cdn.intechopen.com/books/images_new/6764.jpg",editedByType:"Edited by",editors:[{id:"186791",title:"Dr.",name:"Archana",surname:"Tiwari",slug:"archana-tiwari",fullName:"Archana Tiwari"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6425",title:"Probiotics",subtitle:"Current Knowledge and Future Prospects",isOpenForSubmission:!1,hash:"129bd046ff0fb4db6584e5afeebe98fa",slug:"probiotics-current-knowledge-and-future-prospects",bookSignature:"Shymaa Enany",coverURL:"https://cdn.intechopen.com/books/images_new/6425.jpg",editedByType:"Edited by",editors:[{id:"81926",title:"Dr.",name:"Shymaa",surname:"Enany",slug:"shymaa-enany",fullName:"Shymaa Enany"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6685",title:"Basic Biology and Applications of Actinobacteria",subtitle:null,isOpenForSubmission:!1,hash:"301e66d4a6b29d4326c39ff2922ec420",slug:"basic-biology-and-applications-of-actinobacteria",bookSignature:"Shymaa Enany",coverURL:"https://cdn.intechopen.com/books/images_new/6685.jpg",editedByType:"Edited by",editors:[{id:"81926",title:"Dr.",name:"Shymaa",surname:"Enany",slug:"shymaa-enany",fullName:"Shymaa Enany"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7240",title:"Growing and Handling of Bacterial Cultures",subtitle:null,isOpenForSubmission:!1,hash:"a76c3ef7718c0b72d0128817cdcbe6e3",slug:"growing-and-handling-of-bacterial-cultures",bookSignature:"Madhusmita Mishra",coverURL:"https://cdn.intechopen.com/books/images_new/7240.jpg",editedByType:"Edited by",editors:[{id:"204267",title:"Dr.",name:"Madhusmita",surname:"Mishra",slug:"madhusmita-mishra",fullName:"Madhusmita Mishra"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6354",title:"Salmonella",subtitle:"A Re-emerging Pathogen",isOpenForSubmission:!1,hash:"e18481d5470f967439dde815fcd52b57",slug:"salmonella-a-re-emerging-pathogen",bookSignature:"Maria Teresa Mascellino",coverURL:"https://cdn.intechopen.com/books/images_new/6354.jpg",editedByType:"Edited by",editors:[{id:"156556",title:"Prof.",name:"Maria Teresa",surname:"Mascellino",slug:"maria-teresa-mascellino",fullName:"Maria Teresa Mascellino"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],ofsBooks:[]},correction:{item:{id:"79356",slug:"corrigendum-to-has-the-yield-curve-accurately-predicted-the-malaysian-economy-in-the-previous-two-de",title:"Corrigendum to: Has the Yield Curve Accurately Predicted the Malaysian Economy in the Previous Two Decades?",doi:null,correctionPDFUrl:"https://cdn.intechopen.com/pdfs/74511.pdf",downloadPdfUrl:"/chapter/pdf-download/74511",previewPdfUrl:"/chapter/pdf-preview/74511",totalDownloads:null,totalCrossrefCites:null,bibtexUrl:"/chapter/bibtex/74511",risUrl:"/chapter/ris/74511",chapter:{id:"72452",slug:"has-the-yield-curve-accurately-predicted-the-malaysian-economy-in-the-previous-two-decades-",signatures:"Maya Puspa Rahman",dateSubmitted:"December 9th 2019",dateReviewed:"March 21st 2020",datePrePublished:"June 11th 2020",datePublished:"December 23rd 2020",book:{id:"9534",title:"Banking and Finance",subtitle:null,fullTitle:"Banking and Finance",slug:"banking-and-finance",publishedDate:"December 23rd 2020",bookSignature:"Razali Haron, Maizaitulaidawati Md Husin and Michael Murg",coverURL:"https://cdn.intechopen.com/books/images_new/9534.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"206517",title:"Prof.",name:"Razali",middleName:null,surname:"Haron",slug:"razali-haron",fullName:"Razali Haron"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"316535",title:"Associate Prof.",name:"Maya Puspa",middleName:null,surname:"Rahman",fullName:"Maya Puspa Rahman",slug:"maya-puspa-rahman",email:"mayapuspa@iium.edu.my",position:null,institution:{name:"International Islamic University Malaysia",institutionURL:null,country:{name:"Malaysia"}}}]}},chapter:{id:"72452",slug:"has-the-yield-curve-accurately-predicted-the-malaysian-economy-in-the-previous-two-decades-",signatures:"Maya Puspa Rahman",dateSubmitted:"December 9th 2019",dateReviewed:"March 21st 2020",datePrePublished:"June 11th 2020",datePublished:"December 23rd 2020",book:{id:"9534",title:"Banking and Finance",subtitle:null,fullTitle:"Banking and Finance",slug:"banking-and-finance",publishedDate:"December 23rd 2020",bookSignature:"Razali Haron, Maizaitulaidawati Md Husin and Michael Murg",coverURL:"https://cdn.intechopen.com/books/images_new/9534.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"206517",title:"Prof.",name:"Razali",middleName:null,surname:"Haron",slug:"razali-haron",fullName:"Razali Haron"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"316535",title:"Associate Prof.",name:"Maya Puspa",middleName:null,surname:"Rahman",fullName:"Maya Puspa Rahman",slug:"maya-puspa-rahman",email:"mayapuspa@iium.edu.my",position:null,institution:{name:"International Islamic University Malaysia",institutionURL:null,country:{name:"Malaysia"}}}]},book:{id:"9534",title:"Banking and Finance",subtitle:null,fullTitle:"Banking and Finance",slug:"banking-and-finance",publishedDate:"December 23rd 2020",bookSignature:"Razali Haron, Maizaitulaidawati Md Husin and Michael Murg",coverURL:"https://cdn.intechopen.com/books/images_new/9534.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"206517",title:"Prof.",name:"Razali",middleName:null,surname:"Haron",slug:"razali-haron",fullName:"Razali Haron"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}}},ofsBook:{item:{type:"book",id:"11778",leadTitle:null,title:"Correctional Facilities and Correctional Treatment - International Perspectives",subtitle:null,reviewType:"peer-reviewed",abstract:"\r\n\tThe book “Correctional Facilities and Correctional Treatment - International Perspectives” will focus on current issues related to the correctional system in a broader international approach, revisiting some of the well-known problems that prison and community sentences embrace in different countries. The presentation of different correctional systems together with their underlying penal laws will help the reader to conceive how crime and criminals are approached globally.
\r\n\r\n\tThe book intends to revisit some of the typical prison problems (e.g., overcrowding, violence, mental health, drugs, sexuality, suicide, etc) in light of recent research, also providing international indicators of how recidivism is influenced by the way governments change their penal laws. The efficacy of correctional treatment programs and community-based programs on offenders’ recidivism rates will be also discussed. Studies concerning specific groups of the prison population – female prisoners, young prisoners, lifers, but also guards, and other staff members – will be considered to allow the implementation of tailored interventions.
\r\n\r\n\tFinally, the discussion about the future of the prison system and the alternatives related to community sentences or other diversion strategies will be considered, in light of corrections’ sustainability and under the therapeutic justice paradigm.
",isbn:"978-1-80356-615-3",printIsbn:"978-1-80356-614-6",pdfIsbn:"978-1-80356-616-0",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,isNomenclature:!1,hash:"a933550a6966a04e4677a4c0aea8f5b2",bookSignature:"Prof. Rui Abrunhosa Gonçalves",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11778.jpg",keywords:"Correctional Facilities, Correctional Laws, Correctional Treatment, Recidivism, Prison Sentences Efficacy, Community Sentences Efficacy, Corrections and Therapeutic Justice, Overcrowding, Violence, Mental Health, Future Challenges, Economic Sustainability",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"March 31st 2022",dateEndSecondStepPublish:"April 28th 2022",dateEndThirdStepPublish:"June 27th 2022",dateEndFourthStepPublish:"September 15th 2022",dateEndFifthStepPublish:"November 14th 2022",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"4 months",secondStepPassed:!0,areRegistrationsClosed:!0,currentStepOfPublishingProcess:4,editedByType:null,kuFlag:!1,biosketch:"A longtime researcher and therapist in the field of forensic and criminal psychology in the University of Minho, and considered one of the most prominent forensic psychologists in Portugal.",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"198691",title:"Prof.",name:"Rui",middleName:null,surname:"Abrunhosa Gonçalves",slug:"rui-abrunhosa-goncalves",fullName:"Rui Abrunhosa Gonçalves",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"University of Minho",institutionURL:null,country:{name:"Portugal"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"23",title:"Social Sciences",slug:"social-sciences"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"247041",firstName:"Dolores",lastName:"Kuzelj",middleName:null,title:"Ms.",imageUrl:"https://mts.intechopen.com/storage/users/247041/images/7108_n.jpg",email:"dolores@intechopen.com",biography:"As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review, to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact."}},relatedBooks:[{type:"book",id:"6942",title:"Global Social Work",subtitle:"Cutting Edge Issues and Critical Reflections",isOpenForSubmission:!1,hash:"222c8a66edfc7a4a6537af7565bcb3de",slug:"global-social-work-cutting-edge-issues-and-critical-reflections",bookSignature:"Bala Raju Nikku",coverURL:"https://cdn.intechopen.com/books/images_new/6942.jpg",editedByType:"Edited by",editors:[{id:"263576",title:"Dr.",name:"Bala",surname:"Nikku",slug:"bala-nikku",fullName:"Bala Nikku"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6926",title:"Biological Anthropology",subtitle:"Applications and Case Studies",isOpenForSubmission:!1,hash:"5bbb192dffd37a257febf4acfde73bb8",slug:"biological-anthropology-applications-and-case-studies",bookSignature:"Alessio Vovlas",coverURL:"https://cdn.intechopen.com/books/images_new/6926.jpg",editedByType:"Edited by",editors:[{id:"313084",title:"Dr.",name:"Alessio",surname:"Vovlas",slug:"alessio-vovlas",fullName:"Alessio Vovlas"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2270",title:"Fourier Transform",subtitle:"Materials Analysis",isOpenForSubmission:!1,hash:"5e094b066da527193e878e160b4772af",slug:"fourier-transform-materials-analysis",bookSignature:"Salih Mohammed Salih",coverURL:"https://cdn.intechopen.com/books/images_new/2270.jpg",editedByType:"Edited by",editors:[{id:"111691",title:"Dr.Ing.",name:"Salih",surname:"Salih",slug:"salih-salih",fullName:"Salih Salih"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"117",title:"Artificial Neural Networks",subtitle:"Methodological Advances and Biomedical Applications",isOpenForSubmission:!1,hash:null,slug:"artificial-neural-networks-methodological-advances-and-biomedical-applications",bookSignature:"Kenji Suzuki",coverURL:"https://cdn.intechopen.com/books/images_new/117.jpg",editedByType:"Edited by",editors:[{id:"3095",title:"Prof.",name:"Kenji",surname:"Suzuki",slug:"kenji-suzuki",fullName:"Kenji Suzuki"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"872",title:"Organic Pollutants Ten Years After the Stockholm Convention",subtitle:"Environmental and Analytical Update",isOpenForSubmission:!1,hash:"f01dc7077e1d23f3d8f5454985cafa0a",slug:"organic-pollutants-ten-years-after-the-stockholm-convention-environmental-and-analytical-update",bookSignature:"Tomasz Puzyn and Aleksandra Mostrag-Szlichtyng",coverURL:"https://cdn.intechopen.com/books/images_new/872.jpg",editedByType:"Edited by",editors:[{id:"84887",title:"Dr.",name:"Tomasz",surname:"Puzyn",slug:"tomasz-puzyn",fullName:"Tomasz Puzyn"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"80830",title:"Plant Proteome in Response to Abiotic Stress",doi:"10.5772/intechopen.102875",slug:"plant-proteome-in-response-to-abiotic-stress",body:'Food could be a reason for the third world war as severe land competition areas participate in agriculture and habitation. Moreover, food production depends not only on land provided but also on the institutionalization of sustainable crop production related to food safety and security.
It is predicted that by 2050, the world’s population will grow to nearly 10 billion people, and the main issue will be feeding them sustainably. To meet this demand, it is necessary to produce about 50% more food in less than 40 years. And the parameters affecting food production like climate change, scarcity of natural resources, and food-wasting should be considered carefully.
On the other hand, approaching sustainable food availability in agriculture not only depends on a balance between food production sustainability, food security, and food safety, but also to spread food worldwide justly [1, 2].
Hunger and undernutrition are two main consequences of food insecurity. So, finding the solutions to make long-term sustainable agriculture possible concerning its restricting environmental factors is a severe challenge for future studies. As one of the significant environmental factors, climate change is expected to be the most unfavorable challenge for sustainable crop production with consistent and adverse effects on food security in many countries [3, 4]. Climate change could be explained by higher precipitation variability, increasing droughts, or floods accompanied by temperature fluctuation. Findings illustrated that about 90% of arable lands are prone to one or more of the above stresses [5], which cause up to 70% yield losses in major food crops [6].
Agriculture and climate have mutual interaction by affecting each other both positively and negatively. Although, the agriculture industry impacts climate in two main contributions, including leading to approximately 25% of global anthropogenic emissions [7] and about 70% of global water withdrawals [8]. The most serious challenge to reach sustainable agriculture would be environmental stresses with emphasizing abiotic stresses.
Regarding climate impression on-farm activities, climate change could affect crop productivity through direct and indirect pathways. Changes in temperature, water availability, and greater variation in weather conditions are significant direct impact factors [9]. For example, temperature increases cause faster plant growing, shorter cropping seasons, and lower yields subsequently. Moreover, pathways like variation in pests, pathogens, and pollinators could be named indirect effects of environment change on crop yield [10]. For instance, a meta-analysis of 1090 studies on the yield of principal crops subjected to unfavorable environmental conditions confirmed that yield reduction could remarkably happen in long-term agriculture [3].
Environmental alterations’ direct and indirect effects could be managed by developing adaptation mechanisms like using new plant production methods or breeding new plant genotypes resistant/low sensitive to environmental pressure [11]. Identifying and quantifying the role of abiotic stresses on the future of plant products may be detected by using technologies to study plants deeply and finding tolerant related genes, biomarkers, or metabolites to work. Proteomics is a reliable and accurate technique for investigating plants’ responses to various stresses and detecting mechanisms specific to each genotype, stress, or combination of them.
In this chapter, we want to focus on the effects of climate change on agriculture, specifically on the opposing side therefore, various type of abiotic environmental factors limiting plant production at proteome level will be explained with detail and proteomics technology that helps study plants’ proteome profile under stress conditions.
The environment could positively and negatively affect populations, organisms, and ecosystems; that negative impact is named stressors with variation in intensities. Exposure is the interaction across each organism with an environmental stressor that is specific to time and location. Exposure is defined as short term and long term with intensity variation. Suppose exposure leads to different types of internal or external changes, named as the response. Various categories of environmental stressors have been recognized, including climatic stress, biological stressors, biological pollution, physical stress, wildfire, chemical pollution, thermal pollution, and radiation stress [12]. Climatic stress is the primary factor affecting crop production worldwide by expressing drought, flood, heat, and cold.
In contrast with human beings, farmers cannot control environmental stresses and have to accept them as nature, so studies have been focused on finding mechanisms in plants to keep them productive in average conditions and under unfavorable situations.
One of the most critical challenges in plant production is the competition of specifying lands for farms or growing population habitations. So, it is vital to produce more in less area considering climate change and anthropogenic activities consequences [13]. Alteration in natural elements like temperature increasing by 3–5°C in the next 50–100 years is proof of extending drought tress, besides human activities such as increasing consumption of chemical fertilizers, pesticides, and improper usage of groundwater resources resulting in salt stress. Therefore, increasing environmental stresses is inescapable from plant productivity in the future [14]. It should be noticed that stress impact not only depends on environmental conditions but also on plant genotype. Therefore, plant reaction to stress is a specific interaction of genotype × environment that could vary depending on these two parameters [15].
In another way, animals counter to negative pressures by escaping and moving, but for immobile plants, stress is the alarm of the typical environment modifying to uncarvable status. Generally, two types of environmental stress, including biotic stress and abiotic stress, are categorized that biotic stress defines plant condition after subjecting to a biological invader. In contrast, nonliving environmental factors are imposed on plants as abiotic stresses [16]. Biotic and abiotic stresses are essential to be studied in detail as they are the main reasons for plant product loss globally [17]. It needs to be considered that the source of environmental pressure affects the synchronism, diversification, or even the extinction of plants, inevitably related to agriculture development [18].
Biotic stress results from competition for nutrition absorbing between plants and various aggressive range of pests and pathogens, including viruses, bacteria, fungi, nematodes, herbivorous insects, arachnids, and weeds [19, 20]. The level of plant tolerance depends on its balance in responding to biotic stress [21]. Plant starts to activate individual and combined mechanisms in different morphological, physiological, biochemical, and molecular levels, and interaction across these functions expresses plant sensing of stress [22, 23, 24].
One of the significant climatic changes in the next 50–100 years is surface temperature increasing by 3–5°C that in combination with an increasing trend of drought, flood, and heatwaves, will be expected to influence crop productivity negatively and food safety [25, 26, 27]. For instance, drought and heat stress substantially affect seed yields by reducing seed size and number, consequently loss in trait ‘100 seed weight’ and seed quality [28].
Environmental abiotic stressors include drought (water stress), excessive watering (waterlogging) and submergence, extreme temperatures [high and low (chilling, cold, freezing)], salinity due to excessive Na+, deficient or over essential nutrients, chemical factors (heavy metals and pH), extreme levels of light (high and low), radiation (UV-B and UV-A), gaseous pollutants (ozone, sulfur dioxide), mechanical factors, and other less frequently occurring stressors trigger plants negatively by crop quantity and quality losing [5, 20, 29, 30, 31, 32, 33, 34]. Importantly, abiotic stresses cause dramatic detriment in various species and some to 50% yield limitation [32, 33]. It should be noted that about 90% of farmlands are exposed to at least one of the above abiotic stresses [5].
Agriculture is accounting for 70% of total freshwater worldwide usage on average. Therefore, human water consumption competes with agriculture water demand, so it impresses the water availability for commercial plant production with the effect of drought stress [34]. The universal water deficiency directly limits plant production while earth temperature increasing with the trend of warming around 0.8°C over the past 100 years has an indirect effect. For example, global barley production reduces by 10% with each 1°C temperature increase [35, 36]. One of the approaches to accompany plants with growing drought stress could be water use efficiency (WUE). For instance, drought stress remarkably impacts nearly 23 million hectares of rain-fed rice-growing area in Southeast Asia [37]. By developing WUE, plants will use water more efficiently, suitable for drought stress tolerance [38]. Some of the primary effects of drought stress on plants are reducing plant growth rate, photosynthetic function, CO2 concentration, and molecular metabolism [38].
Soil salinity is not only caused by environmental activities or factors like environmental pollution, especially in arid and semiarid arable lands but also could be related to drought stress by a deficiency in water resources. Salinity directly limits crop productivity, food safety, and agriculture sustainability by gradually cultivating salinized lands [39, 40]. The severity of salinization could be sensed better by finding that around 970 million hectares, 8% of arable lands, are impacted by a high level of salinity stress [41].
Specific effects of salt stress on plants could be explained physiologically by reducing seedling germination percentage, shoot and root length, fresh and dry weight, and necrotic leaf tissue morphologically and K+ and Ca2+ level deficiency continued with osmotic and oxidative stresses at the molecular level, especially in plant leaves [42, 43, 44, 45].
Temperature stress is a geographical dependent variable that defines high-temperature stress and low-temperature stress. Suppose the climate condition declines to less than 15°C, known as chilling or cold stress, while by greater decreasing to less than <0°C, freezing stress happens. Generally speaking, low-temperature stress is detrimental stress detracting plant growth and yield by affecting germination, seedlings growing, the color of leaves, and tillering continued in declining pollen sterility [46, 47].
Against low temperature, increasing temperature to a higher level than plants tolerance modifies plant growth and productivity negatively. High temperature or heat stress disturbs a plant’s average growth morphologically, physiologically, and in molecular aspects like protein degradation or modification, instability of enzymes, nucleic acids, biomembranes, and cytoskeletal structures [48].
Cold and freezing stresses affect plant production significantly by decreasing production or even plant death. The plant generally adapts to such severe stress conditions to survive; however, many plants cannot tolerate it [14]. Cold stress categorizes plants, with different resistance levels, into three groups: delicate chili plants that are highly sensitive to a low temperature just lower than 15°C and damage seriously. The second category, chilling resistant plants, which are medium tolerant to cold stress and are temperature around 0°C, causes stress. Nevertheless, the last plant group is frost-resistant plants that acclimate to shallow temperatures even by ice formation. Cold stress resulted in membrane instability, ion exchange disturbance, and electrolyte leakage [49].
Temperature increasing is a severe concern of future plant productivity. Heat stress impacts plant productivity variously in morphological, biochemical, and molecular levels. Plant growth and development decrease, seed germination decline beside photosynthetic lower efficiency all together trigger yield loss as a consequence of heat stress [14, 50]. Another effect of high temperature is accelerating plant growth, especially during the vegetative stage, to mature faster by fruit or seed production. Notably, heat stress could signal drought stress by increasing transpiration and, finally, water evaporation [51].
Soil plays a vital role in plant growth by providing nutrients; however, the amount of soil solution determines whether to call them nutrition. Heavy metal toxicity results from the high concentration of metalloids contaminate the soil with the possibility of absorbance into plant tissues and frustrating plant normal life cycle [52]. Unlikely, metal toxicity is predicted to cause mutagenic impacts on crops due to improper and sewage wastewater irrigation methods, redundant adding of chemical fertilizers to the soil, and rapid industrialization [14, 53]. Two main metal categories are recognized in soil that may lead to mental stress, namely vital micronutrients for average plant growth that become toxic if accumulating in excess in soil solution (Fe, Mg, Mo, Zn, Mn, Cu, and Ni) and non-essential elements with unknown physiological and biological function; however can damage the plant by accumulating in the soil even in modicum amounts (Ag, Cr, Cd, Co, As, Sb, Pb, Se, and Hg) [54, 55, 56]. These vital elements are crucial for enzyme and protein structure in plants, but their excessive presence is not helpful and causes abiotic stress in plants [57].
Plant adaptation in response to abiotic stresses includes a matrix and interaction of various morphological, biochemical, and molecular mechanisms. Morphological alterations are the visible symptoms, representing plant unfavorable condition after stress subjection. However, the number of unique responses happen in the plant adaptation process, some of the common effects like wilting due to water flow decrement, reduction in photosynthetic ability with the result of tiller number decreasing, reducing leaf growth, and increasing root length [58, 59].
Many biochemical mechanisms inducing adaption to stress in plants are regulated by increasing phytohormones levels [60]. Abscisic acid (ABA), jasmonic acid (JA), and ethylene are the main hormones leading to secondary stresses in plants such as osmotic and oxidative stresses [33, 61, 62]. Oxidative stress results from reactive oxygen species production, which generally happens in response to extreme temperature treatment. In contrast, salt and drought stresses lead to an osmotic imbalance in cells and cause osmotic stress [63]. By concomitant osmotic and oxidative stress under abiotic stresses, plant changes biochemically with some common responses like stomatal closure, reducing photosynthesis-related variables like gas exchange factors, declining photosynthesis, and increasing reactive oxygen scavenging activity [59]. Notably, the photosynthesis mechanism is a crucial physiologic parameter influence on yield output, and increasing in related variables helps plant adaptation experiencing unfavorable conditions [64, 65]. Positive induction of phytohormones in stress-subjected plants signals overexpression of the genes related to stress tolerance [66].
A comprehensive understanding of stress responses in plants needs to study the whole network interaction happening in plants involving individual or shared responses. Molecular mechanisms including proteome, transcriptome, genome, and metabolome modification analysis help find genes responsible for plant tolerance under abiotic stress [67, 68]. Genes encoding proteases, chaperonins, enzymes of sugar, proline, ion, and water channel proteins, enzymes contribute to oxidative stress, transcription factors (TFs), and protein kinases help to protect the plant against abiotic stress by overexpression [69]. Moreover, phytohormone signaling regulates some genes like ABA-dependent factor expression after exposure to abiotic stress. Basic leucine zipper (bZIP) TFs are an example of this category, leading tolerance-related responses like stomatal closure and expression of dehydration tolerance genes. However, there is another category of ABA-independent mechanisms [70].
As the proteome is dynamic in plants both in control and stress conditions, its profile analysis is not only an appropriate approach to study related genome function but also is informative to analyze post-translational modification, protein-protein interactions, protein regulation mechanisms, and metabolic networks [71, 72, 73]. Therefore, proteomics is a powerful tool to identify genes responsible for stress tolerance. Moreover, proteome identification and physiology analysis could provide information to detect genome, stress, or term-related genes or potential biomarkers for a better description level of stress tolerance in each genotype [74].
Mass spectrometry assists with chromatographic instrumentation, and electrophoretic techniques are the primary method for proteome identification and quantification [75]. The application of advanced proteomics technologies like isobaric tags labeling allows characterizing a more significant number of proteins with lower abundance [76].
Plant response to stress in four phases depends on the severity, duration, or recovery process, including the alarm, acclimation, resistance, and exhaustion phases. In the aspect of proteome level, the alarm phase involves modification in signaling-related proteins [77, 78]. Tolerant genotypes shift to the acclimation phase by activating energy and protein metabolism due to the high demand of energy production for enzymes activity. Glycolysis is one of the carbohydrate catabolism that upregulated under the acclimation process in contrast with enzymes related to the biosynthesis of energy-rich compounds like sucrose synthase [77, 79]. Protein metabolism defines a balance between protein biosynthesis and degradation to keep protein homeostasis in plants. The acclimation phase considers as one of the significant differences in proteome changes across stress-tolerant and stress-sensitive genotypes.
There are two main categories of proteins that participate in plant response to stress; the first group contains functional proteins. Late embryogenesis abundant (LEA) protein family plays a crucial role in tolerance mechanism in plants and found increasing in abundant under drought, heat, salinity, cold, and mechanical wounding [80, 81, 82, 83, 84]. Dehydrins are one group of LEA proteins whose overexpression under abiotic stress acclimate plants to abiotic stress, though their exact function is still unclear [85]. Another group of functional proteins is the heat shock protein (HSP) family and chaperones. These proteins are responsible for protecting proteins from aggregation and misfolding and consequently avoiding imbalances in cellular homeostasis. Many reports show that HSPs and chaperons are crucial in plant tolerance after exposure to abiotic stresses like extreme temperatures and drought stresses [86].
Enzymes cooperate in plant tolerance by two mechanisms, including energy production, as discussed before, and ascorbate peroxidase (APX) and catalase are two examples of proteins correlated to detoxification of reactive oxygen species (ROS) in response to abiotic stress like low-temperature conditions [87]. For example, accumulation of H2O2 as signal transduction molecule in response to abiotic stress, triggers to cellular damage, and inhibition of photosynthesis [88].
In response to different abiotic stress in plants, stress-induced signal transduction pathways initiate by various signaling receptors includes reactive oxygen species (ROS) [89, 90, 91]. Most dominating ROS include hydrogen peroxide (H2O2), hydroxyl radical (OH*), singlet oxygen (1O2), superoxide radical (O2*−), etc. [92] that induced ROS overproduction serves various signaling cascades to regulate stress responses in plants like acclimation or defense by activating downstream metabolic pathways [90, 91, 93, 94]. Studies have found that ROS plays pivotal role mainly as primary signals under unfavorable conditions and interact with other signaling molecules like calcium, MAPKs, plant hormones, and transcription factors [95]. Oxidative stress is the consequence of any misbalance between ROS production and scavenging in plants, lead to proteins function and structure altering and damaging DNA, RNA, and other molecules [96, 97, 98].
In addition to ROS, phytohormones are activated under unfavorable condition by modulating stress-adaptive signaling cascades. Abscisic acid (ABA) regulates various physiological processes ranging from stomatal opening to protein storage and coordinate complex stress-adaptive signaling cascades. ABA is also an important messenger that acts as a critical regulator in activating plant cellular adaptation to different environmental stress conditions [99, 100].
The other functional proteins related to stress tolerance involve ion transporter and membrane proteins that help keep membrane stability by an incredible increase. V-ATPase and channel proteins (NHX-1) increased under salinity in plants [85, 101].
The second group of proteins activated under stress is regulatory proteins, namely, photosynthesis-related proteins, Transcription factors (TF), kinases, phosphatases, and signaling proteins [85]. The photosynthesis mechanism has a very crucial role in plant reaction to stress. Plant decreases photosynthesis-related proteins abundant as try to slow down the growth pace to avoid death happening and closing stomata to avoid water loss, such as RubisCO and chlorophyll a-b binding proteins in both photosystems (PS) I and II found downregulated under low temperature and flood stress [102]. Transcription factors (TF) generally regulate genes expression under stress with the ability of binding specific sequences to these genes and lead tolerance in plants exposed to stress [103]. Mitogen-activated protein kinase (MAPK) is an example of kinases proteins with a particular function in regulating plant responses to unfavorable environmental conditions [104, 105]. On the other hand, kinases coordinate in stress tolerance by the phosphorylation mechanism. Several kinases are found with this function, such as CDPK, MAPK, and SnRK2 [106]. The major subcellular organelles, whose functions get affected under abiotic stress, are the nucleus, mitochondria, chloroplasts, peroxisomes, plasma membrane, and cell wall. Most of these organelles have the potential to become a source of ROS.
Salinity stress represents enhanced levels of salt ions in soil water solution. As a consequence of enhanced ion levels, decreased soil water potential reveals a so-called osmotic effect on plant cells [78].
Increasing salt (mainly Na+) accumulation which is known as salt stress in plants, leads to several metabolite modifications; however, the plant species, the age of the plant, and Na+ concentration are three main factors affecting the stress severity. For example, by increasing Na+ concentration, salt stress ranges from osmotic stress to osmotic shock [107]. In the short term, high Na+ and Cl− concentration causes osmotic stress by misbalance in intracellular ion homeostasis due to decreasing K+ transport with excess toxic intracellular Na+ ions in the cytosol; therefore, plants exposes to ionic stress [108, 109].
Osmotic stress affects plant cellular metabolism in different ways like membrane fluidity, production, and accumulation of reactive oxygen species (ROS) and further oxidative stress happening, photosynthesis malfunction by stomatal conductance decreasing [108, 109, 110]. The K+/Na+ discrimination ratio causes inhibiting K+ ion uptaking as a vital factor related to many growing and development functions in plants indirectly leads to plant death [111]. To balance ionic homeostasis, an increase in the concentration of cytosolic Ca2+ activates some proteins like antiporters and enzymes involved in the transport of ions and phospholipases [112]. Induced accumulation of Ca2+ activates H+-ATPases as an ion-transporting protein to maintain cytosolic ion homeostasis. On the other hand, the elevated activity of H+-ATPases is vital to avoid electrochemical gradient misbalance and maintain cellular pH homeostasis [113, 114].
Osmotic stress is another consequence of a high concentration of Na+ in soil, which could be considered a primary signal of ionic stress. Plants sense the osmotic stress by losing leaf water due to high salinity and water capacity absorption decreasing. Therefore, salinity is known as hyperosmotic stress [108, 115]. Na+ uptaking to plant roots happens via apoplastic or symplastic routes through Na+ transport transmembrane proteins and Na+/H+ exchangers.
Oxidative homeostasis is misbalanced due to photosynthetic activity and energy metabolism reduction, which induce the accumulation of ROS. Intracellular ROS is a critical signaling molecule promoting oxidative stress induction [41, 116]. Excess ROS accumulation, recognized as a marker of oxidative stress, may be removed by ROS scavengers. Two main groups have been found responsible for oxidative stress response in plants like enzymatic or non-enzymatic antioxidants. Antioxidant enzymes are identified by ameliorating some antioxidative enzyme activities, while other antioxidant mechanisms could play more effective participation in oxidative response [117, 118]. Recent studies on crop plants have identified the following five main groups of proteins that present differential abundance and are directly related to salt stress response mechanisms: (I) heat shock proteins (HSPs), (II) late embryogenesis abundant proteins (LEA proteins), (III) osmolyte and flavonoids biosynthetic enzymes, (IV) proteins involved in carbon, photosynthesis and energy metabolism like rubisco activase, kinases, and oxygen-evolving enhancer protein 2 (OEE 2), and (V) enzyme scavengers of ROS such as catalase, peroxidase, and GST [86, 102, 113, 117, 119].
Drought means a decreased soil water potential which causes reduced water uptake by roots. Plant response at the molecular level lies in osmotic adjustment, that is, a decrease in osmotic potential of cell cytoplasm due to an enhanced accumulation of several osmolytes and hydrophilic proteins. The primary signal caused by drought is hyperosmotic stress, which is often referred to simply as osmotic stress because a hypo-osmotic condition typically is not a significant problem for plant cells. In leaves, drought leads to stomatal closure associated with reduced CO2 uptake resulting in imbalances between photosynthetic electron transport processes and carbon assimilation. As a consequence, cellular dehydration is also associated with enhanced ROS formation [120].
Water losing causes decreasing in leaf water potential in contrast with cytoplasmic components concentration and extracellular matrices viscosity increase [121, 122]. In response to drought stress, CO2 production declines due to stomatal closing. On the other hand, photosynthesis may be known as the first and most significant function negatively affected by water deficiency stress [123, 124].
Decreasing in internal CO2 concentration impacts on Calvin cycle by disturbing carbon fixation accompanied with a proportional reduction in the activity of various related enzymes like fructose-1,6-biphosphate phosphatase (FBPase), ribulose-1,5-bisphosphate carboxylase-oxygenase (Rubisco), and phosphoribulokinase (PRK). Consequently, glycerate-3-phosphate depletion and NADP+ production decline lead to carbohydrate formation decrease in the final step of the Calvin cycle. Moreover, NADP+ is the primary electron acceptor in photosystem I (PSI), and therefore O2 production, lowered as the final production of photosynthesis in plants and excessive generation of reactive oxygen species (ROS) occurs [125, 126, 127, 128]. Moreover, reducing ATP production in response to drought stress is associated with photosynthesis function by negatively affecting the Calvin cycle.
A coordinated down-regulation of the Calvin cycle genes with a decline in carbon fixation in plants exposed to drought stress reduces the energy-wasting for unnecessary biomolecule synthesis through the lower level of carbohydrate production [129].
Under drought stress, due to low CO2:O2 ratio ribulose-1,5-bisphosphate carboxylase-oxygenase (RuBisCO) enzyme oxygenates ribulose 1,5-bisphosphate (RuBP) and causes photorespiration (C2 photosynthesis) cycle to function as a carbon recovery system which is correlated with the Calvin cycle [130].
The Krebs cycle (TCA cycle) is one of the primary energy sources for cells and essential for aerobic respiration. There are contradictory reports for effects of drought stress on the Krebs cycle and its intermediate such as PDHA1, NADP-ME, and α-ketoglutaric acid [131, 132, 133].
Another cycle affected by drought stress is the ascorbate-glutathione (ASA-GSH) cycle detoxifies waste hydrogen peroxide (H2O2) to H2O by using antioxidant metabolites like ascorbate, glutathione, and NADPH and the enzymes linking these metabolites [134, 135].
Temperature stress (both heat and cold) leads to an imbalance between photosynthetic electron transport processes and carbon assimilation processes resulting in enhanced photoinhibition and thermal energy dissipation [136] and is linked to plant metabolism and performance [137]. The synthesis and accumulation of heat-shock proteins (HSPs) is a prompt response after exposure to extreme temperature stress treatment. It is considered one of the most critical adaptive strategies to overcome the deleterious effects of temperature fluctuation stress [138, 139]. Most HSPs are molecular chaperones involved in protein stabilization and signal transduction during heat stress [140, 141].
Low temperatures (cold and frost) can induce inhibition of water uptake and indirectly result in osmotic stress in cells [142]. Consequently, decreased kinetics of biomolecules leading to reduced cell membrane fluidity and a decreased rate of enzymatic reactions. Frost stress particularly leads to ice crystals in soil, resulting in cellular dehydration [78].
High temperature (heat) stress as enhanced temperature causes enhanced kinetics of biomolecules leading to an enhanced risk of protein misfolding. Thus, plant response includes induction of several heat-shock transcription factors (HSFs) and downstream heat-shock proteins (HSPs). Moreover, heat causes enhanced water evaporation from the soil surface and enhanced leaf transpiration, thus usually resulting in water deficit under field conditions. The heat thus also causes dehydration stress and oxidative stress [136].
Plant production in two aspects of quality and quantity plays a key role in food safety and security impressed with global environmental stresses increasing with emphasizing on study to detect plant alterations in response to abiotic stresses. Different levels of plants sense stresses from morphological to molecular aspects however finding deep mechanisms and functions affected by stresses would help to find related genes and biomarkers more accurately. We reviewed the significance of agriculture for our future in addition to its mutual relationship with environment. Climate change as the most effective parameter correlated with food production, is susceptible to impact negatively on both food safety and food security.
Analyzing the proteome profile of plants exposing various types of abiotic stresses including salt, drought and extreme temperature is helpful to find shared and unique mechanisms related to abiotic stresses in addition to finding solution useful for crop production increasing and sustainability.
Parasitic diseases are a global problem for health and animal production performance due to endoparasites or ectoparasites, Among ectoparasites (ticks, mites, flies, fleas mosquitoes etc.), ticks have adapted to most of the terrestrial niches on the planet and have specialized in feeding on the blood of mammals, birds and reptiles around the world [1, 2, 3]. The evolutionary adaptation of ticks to hematophagy, is the major reason of the great economic losses caused by this group of parasites, however, the greatest impact of tick infestations to human and animal health is also related with the tick borne diseases.
Ticks are considered responsible for more than 100,000 cases of human diseases, and are the most important vectors of disease-causing pathogens in wild and domestic animals. Globally, they are the second most important disease vectors in humans only after the mosquitoes [4, 5], however they are considered to be the most important vector of pathogens in North America [6].
The families Argasidae and Ixodidae are two groups of thelmophagous ticks of great importance for human and animal health, since they act as reservoirs of a lot of pathogens including parasitic protozoos (
Ticks belong to the group of ectoparasites that cause important economic losses in the cattle industry in tropical and subtropical ecosystems all over the world. Specifically,
Life cycle of the one host thelmophagous cattle tick Rhipicephalus (Boophilus) microplus, showing a parasitic and a free living stage and four different ontological forms: Egg, larvae, nymph and adult or engorged female. (Artwork composed by Fernando Rosario & Delia Inés Dominguez 2021).
Bovine cattle is parasitized by
The parasitic phase (Figure 1), begins when the larvae overcome the climatic and host barriers, since its life cycle is influenced by climatic factors acting on the free living tick stage and the host response against the tick as a parasite. Larvae, then reaches the bovine skin, where they will start the physiological processes of feeding, molting and copulation of the larva, nymph and adult stages respectively [14]. The duration of the parasitic phase is relatively constant, it has been estimated that the duration of this stage from larvae to the adult engorged female, occurs approximately from 18 to 22 days, including feeding, molting and change to the next stage; the whole process takes place all the time on the bovine. The mortality rate of ticks in this phase is determined by the resistance of the host, since, larvae as we already mentioned, is influenced by changing climatic factors as well as the host response against the different tick parasitic stages, the larvae, nymph and the adult engorged female [14].
The non-parasitic phase (Figure 1), begins when the engorged female detaches from the host in search of suitable places for oviposition, the eggs laid remain under the grass, until the larvae hatches and appear on the grassland ready to infest the bovine host. Under the grass, the non-parasitic cycle goes through several stages: pre-oviposition, oviposition, incubation and larval hatching. The intervals duration for the completion of each stage, are variable and greatly conditioned by factors such as season, host abundance, selection of host species, and the climatic conditions mainly humidity and temperature [15]. Biologically, these processes involve the physiological and behavioral response of ticks to temperature, moisture stress and day length that result in specific patterns of seasonal population dynamics and hosts availability [14].
Undoubtedly Ticks are the most important group of pathogen vectors causing diseases in wild and domestic animals [5]. Its great economic and sanitary importance is due to its wide distribution, vectorial capacity, hematophagous habits and the number of cattle it affects [17].
The control of tick populations and the diseases they transmit in countries with emerging economies in Latin America, is a prevailing need due to the millionaire economic losses they cause. On the other hand acaricides with a tick-killing effect is the main tool available to control ticks [18].
The cattle fever tick
Infested cow from the Northern transboundary region between Mexico and the United States, shows the tick infestations resulting from the intensive use of acaricides based on a regular and systematic chemical application approach. (The photograph has been kindly provided by Dr. Martin Ortiz Estrada).
Map showing the distribution of the cattle tick Rhipicephalus (Boophilus) microplus and the current state of tick control officially recognized by the National Tick Campaign Office from the National Center for Verification Services on Animal Health SENASICA from the Mexican Government. Consulted and taken from the official SENASICA web site on August 19, 2021. (
Acaricides have been intensively used for tick control; as a result the use of chemicals combined with the plasticity of tick genomes, has increased progressively the appearance of resistance to different families of acaricides unavoidably (Figures 2 and 4) [22], and in many cases to the appearance of multiple resistance. The appearance of resistance in the cattle industry has highlighted the greater inconvenience of the use of acaricides, the selection of resistant tick populations due to the use of acaricides or mixtures of acaricides elaborated based on the ignorance of the resistance mechanisms [22]. There are some critical and basic concepts that allow us to make a road map, on how acaricide resistance occurs, after the continuous and frequent application of chemical treatments. After the continuous exposure, the acaricide kills a fraction of the susceptible ticks, and an increase of tick resistant phenotypes gradually occurs, as illustrated in Figure 4. As a consequence, the half-life of pesticides in some regions of northern Mexico has been reduced to such a degree that they no longer represent an alternative to control ticks (Figure 2), and the interest of looking for new approaches is currently focused to search for new potentially useful immunogenic vaccine candidates to control resistant tick populations [23].
Theoretical illustration showing the increase of acaricide resistance phenotypes and/or allele frequency levels in a tick population. Some individuals (black) with genetic traits allowing them to survive the acaricide applications can reproduce; if the selection pressure is frequent, they progressively become the preponderant part of the tick population. (Artwork composed by Fernando Rosario & Delia Inés Dominguez 2021).
Acaricide resistance is a genetic condition driven by randomly arise genetic traits that can be inherited to the progeny and spread throughout the population along time, promoted by natural or artificial selective pressure on a toxic environment, contaminated with synthetic or natural acaricides.
Parasitic diseases have become a global problem due to free trade agreements or commercial exchange of goods and services, because the geographical borders between countries have disappeared from the political geography. One of the biggest issues associated with exportation and importation of animals and products, is the free movement of vector and vector borne diseases associated with animal health and food safety [24], as well as the tick genomes, encoding the acaricide resistance traits that will be transferred to the progeny.
Two general mechanisms of acaricide resistance have been described in
Illustration showing the different phases of detoxification mechanisms and the participation of multigenic families of hydrolyzing (Esterases and cytochrome P450), modifying enzymes (GST) or the group of transporter proteins ATP binding Cassette (ABCt) at different levels of the metabolic detoxification process (transformation, conjugation and exportation). (Artwork composed by Fernando Rosario & Delia Inés Dominguez 2021).
However, the most common mechanism in pyrethroid resistant tick populations in the field, is the target site modification, mediated by a substitution occurring on gene sequences as it was demonstrated for the occurrence of a point mutation located at the segment six domine III (S6III) of the sodium channel gene [30], which encodes the substitution of a Phenylalanine by an Isoleucine in Mexican field samples (Figure 6).
Genotype and larval survival percentages obtained by the allele specific PCR and LPT respectively, were plotted in order to show the statistical correlation between the presence of the mutation on the sodium channel gene and the resistance to pyrethroids in samples collected from Yucatán, Mexico (p < 0.05). Tick strains were classified by their phenotype as: Very resistant (strains 1, 2 and 3), intermediate resistance (strains 4, 5 and 6) and very susceptible (7, 8 and 9). Genotypes are represented by blue bars and phenotypes by red bars. (Graph from Dr. R. Rosario-Cruz archives).
Figure 6, show the association between genotypes and phenotypes of nine tick strains that were grouped based on three different phenotypes: very resistant, moderately resistant and susceptible to pyrethroids as measured by the larval packet test (LPT) and later analyzed by the allele specific PCR amplification test in order to identify the three different genotypes (RR, RS and SS) in samples collected from Yucatán, Mexico.
Results demonstrated that PCR test can be used as a molecular tool to detect and predict the appearance of pyrethroid resistance phenotypes, since a resistant allele frequency lower than ten percent, started showing up in the susceptible strains while they were still susceptible as measured by the LPT [30]. According to this results the genotype and phenotype frequency (Figure 3) increases in parallel with the continuous application of acaricides (p < 0.05) (Figure 4).
Up to date, numerous studies have been reported in order to predict the mode of inheritance of pyrethroid resistance in various insects such as mosquitoes (31), the horn fly
There are evidences demonstrating that in
The use of acaricides has been the most important tool against ticks; however, the abuse of chemical control has led to multiple resistance to different classes of commercially available acaricides [36, 37]. Due to recent problems of multiple resistance, different research groups in Mexico and around the world, have focused on finding different alternatives such as plant extracts with acaricide activity [38] and recombinant proteins, potentially useful for vaccine development as an alternative to control tick infestations caused by
Livestock industry in tropical and subtropical regions of the world, is affected by tick infestations, and the economic losses it causes due to the direct effects associated to their blood-sucking habits, such as skin damage and pathogens transmission in tropical and subtropical areas [5, 12, 40]. The producers also have important losses associated with decreased weight gain and low production of milk and meat due to the economical impact on cattle by pathogens causing Babesiosis (
The cattle tick control has been traditionally based on application of acaricide strategies, by dip bath, sprying, pour on or injection, ignoring the consequences of frequent acaricide applications and the biology of the vector. In some states of Mexico, multi-resistance is a constant and current threat, which affects the National livestock production and therefore the economy of producers, since they depend completely on the use of acaricides, but do not have access to technical advice from any public or private office, in order to design a control program to prevent the sudden loss of efficacy of the acaricides used for tick control [43].
The most reliable information on global economic losses, date from the 1980s, these figures estimate that one billion head of cattle are exposed to tick infestations in tropical and subtropical regions of the world and in 1984, economic losses were estimated in eight US billion dollars [44].
Reported data in the literature does not include the loss of human life due to ticks and tick borne diseases, such as the thousands of cases of Lyme disease that occur annually in Europe and North America [45, 46], tick-borne encephalitis cases in Europe [47], and tick-borne rocky spotted fever cases in the United States [48].
In the context of animal health, the most important tick is
Recent experimental trials of an integrated tick management (ITM) program in Mexico, suggest that ITM programs should included the combined use of acaricides with an anti-tick vaccine against
Comparison of 21 days old adult engorged females, collected from vaccinated and unvaccinated cattle under an integrated tick management program in the coastal state of Guerrero, Mexico. (Photo from Dr. R. Rosario-Cruz archives).
These data was used to calculate the reduction of production costs due to the purchase of pesticides but did not include the purchase of antibiotics to control babesiosis and anaplasmosis, for calculation purposes [52]. The cost of chemical tick control in this study was $ 408.3 Mexican pesos per animal, while the combined program was only $ 128 pesos, which mean a reduction of 68.63% for the purchase of ixodicides.
The extrapolation of these data to the national livestock herd estimated in 30 million head of cattle, is equivalent to 12,248.7 million Mexican pesos. The use of a combined control program would reduce these losses from 12,248.7 million of Mexican pesos to 3,843.7, that is a reduction of 68.63% of the losses applied to the Mexican livestock herd [52].
The data published in this paper shows an estimated annual loss of 942 million USA dollars, (considering a current exchange rate of 20 Mexican pesos/US dollar, the equivalent annual losses would be 612 US million Dollar) it is worth mentioning that this and other previously published papers, does not include the loss of animals dead by ticks and tick borne diseases such as Babesiosis and Anaplasmosis, nor the expenses produced by the costs of the medication used to control these tick borne pathogens which can double the annual losses due to tick infestations.
Edward Jenner was the first to scientifically prove in studies carried out in 1796, a method to protect against smallpox, thereby laying the foundations of vaccinology, and although the invention is not directly attributed to him, he is often considered the father of vaccines due to his scientific approach that proved that the “vaccination” method worked, and from then until today, more than 200 years after its discovery, new biotechnological tools have substantially improved not only the application of vaccines, but the way to produce them.
A vaccine is a biological preparation that provides an active acquired immunity to a particular pathogen. The vaccine preparation stimulates the immune system to recognize a foreign threat and thus destroys and remembers it, so that the immune system can easily destroy any of these pathogens when they later invade into the body. The vaccine characteristics can be enhanced by Biotechnology.
Vaccines have been the most significant advance in public health, and its preventive prophylactic treatment has been demonstrated as we mentioned, for over 200 years for bacterial and viral diseases preventing morbidity and mortality in millions of people annually [53]. Vaccine development during the pre-genomic era was based on the use of dead, live or attenuated organism or on the use of subunitarian proteins purified from total extracts from organisms of interest [54].
These subunitarian proteins may contain one or more antigens combined. To develop such vaccines is a critical necessary step, identification of proteins of interest and eliminating others that are not useful. In this particular case, in order to be recognized as protector, an antigen must be able to limit the development or reproduction of the organism, parasite or pest in question in subsequent exposure challenges [55].
The empirical approach to the development of subunit vaccines includes several steps: a) culturing the parasite, microorganism or pest to be controlled, b) the analysis, and identification of its components, c) purification of antigens having immunogenic properties required for product development and d) the subsequent challenge with the infectious agent or parasite against which we want to develop the vaccine, in an appropriate animal model to evaluate the immunogenic characteristics of this technology [56, 57].
This methodology has difficulties inherent in the process of identification and purification of the fractions possessing the optimal antigenic characteristics for vaccine development and the availability of macro or microorganism to be controlled by this biotechnological tool because the vaccine production It is severely limited when the target organism cannot easily grow [58]. There are other drawbacks that have to do also with the biology of the target organism, since in some cases the most abundant proteins are not necessarily immunoprotective, or may be the case that the antigens expressed during in vivo or infestation infection as the case are not the same as those expressed during cultivation in vitro latter may not be the case in ticks [59].
Difficult as it may seems, the hard work has already made great progresses, the number of cloned and analyzed genes are already a big list, and experiments have shown that genes as Bm86, subolesin, ferritin, aquaporin and a growing number of orthologous genes can be used to control ticks. The future in the field of vaccine development is becoming shorter, and the scope of modern technology in the field is increasingly longer. Landing knowledge regarding the tick vaccines development for tick control, is very close to pays off as seen by the growing list of new antigens discovered, although the tick control still represents a challenge for the scientific community.
Ticks and tick-borne pathogens constitute a growing problem for human and animal health worldwide, since, they are considered, the most important vectors of disease-causing pathogens in wild and domestic animals and the second most important vector of pathogens causing diseases in humans, only after the mosquitoes.
Resistance to acaricides impacts directly the economy and the competitiveness of producers, and its presence within the ranches implies the expenses associated to control of ticks and tick borne diseases. Efficient integrated control programs are required to mitigate the direct effects on cattle infested with resistant ticks, and to keep a low prevalence of tick borne diseases.
The use of an integrated tick management program in Mexico, including a combined control strategy (acaricides and tick vaccine), reduced the use of acaricides for tick control by 80% approximately, with a cost–benefit ratio of 3:1, lowering the environmental and food products contamination derived from this activity, reducing the mortality attributed to Babesiosis and Anaplasmosis and contributing to the development of a sustainable, and environmentally friendly livestock production system.
New candidate protective antigens and research on tick vaccine development need to be addressed to establish and design better strategic control programs, since vaccines have demonstrated to be the most effective and an environmentally friendly intervention for the control of tick infestations and tick-borne diseases.
The hard work, difficult as it may seems, has already made great progresses, the future in the field of tick vaccine development is becoming shorter, and very close to pays off as seen by the growing list of new antigens discovered, although the tick control still represents an innovation challenge for the scientific community in Mexico and all over the world.
The authors declare having no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript.
This is a brief overview of the main steps involved in publishing with IntechOpen Compacts, Monographs and Edited Books. Once you submit your proposal you will be appointed a Author Service Manager who will be your single point of contact and lead you through all the described steps below.
",metaTitle:"Publishing Process Steps and Descriptions",metaDescription:"This is a brief overview of the main steps involved in publishing with InTechOpen Compacts, Monographs and Edited Books. Once you submit your proposal you will be appointed a Publishing Process Manager who will be your single point of contact and lead you through all the described steps below.",metaKeywords:null,canonicalURL:"page/publishing-process-steps",contentRaw:'[{"type":"htmlEditorComponent","content":"1. SEND YOUR PROPOSAL
\\n\\nPlease complete the publishing proposal form. The completed form should serve as an overview of your future Compacts, Monograph or Edited Book. Once submitted, your publishing proposal will be sent for evaluation, and a notice of acceptance or rejection will be sent within 10 to 30 working days from the date of submission.
\\n\\n2. SUBMIT YOUR MANUSCRIPT
\\n\\nAfter approval, you will proceed in submitting your full-length manuscript. 50-130 pages for compacts, 130-500 for Monographs & Edited Books.Your full-length manuscript must follow IntechOpen's Author Guidelines and comply with our publishing rules. Once the manuscript is submitted, but before it is forwarded for peer review, it will be screened for plagiarism.
\\n\\n3. PEER REVIEW RESULTS
\\n\\nExternal reviewers will evaluate your manuscript and provide you with their feedback. You may be asked to revise your draft, or parts of your draft, provide additional information and make any other necessary changes according to their comments and suggestions.
\\n\\n4. ACCEPTANCE AND PRICE QUOTE
\\n\\nIf the manuscript is formally accepted after peer review you will receive a formal Notice of Acceptance, and a price quote.
\\n\\nThe Open Access Publishing Fee of your IntechOpen Compacts, Monograph or Edited Book depends on the volume of the publication and includes: project management, editorial and peer review services, technical editing, language copyediting, cover design and book layout, book promotion and ISBN assignment.
\\n\\nWe will send you your price quote and after it has been accepted (by both the author and the publisher), both parties will sign a Statement of Work binding them to adhere to the agreed upon terms.
\\n\\nAt this step you will also be asked to accept the Copyright Agreement.
\\n\\n5. LANGUAGE COPYEDITING, TECHNICAL EDITING AND TYPESET PROOF
\\n\\nYour manuscript will be sent to Straive, a leader in content solution services, for language copyediting. You will then receive a typeset proof formatted in XML and available online in HTML and PDF to proofread and check for completeness. The first typeset proof of your manuscript is usually available 10 days after its original submission.
\\n\\nAfter we receive your proof corrections and a final typeset of the manuscript is approved, your manuscript is sent to our in house DTP department for technical formatting and online publication preparation.
\\n\\nAdditionally, you will be asked to provide a profile picture (face or chest-up portrait photograph) and a short summary of the book which is required for the book cover design.
\\n\\n6. INVOICE PAYMENT
\\n\\nThe invoice is generally paid by the author, the author’s institution or funder. The payment can be made by credit card from your Author Panel (one will be assigned to you at the beginning of the project), or via bank transfer as indicated on the invoice. We currently accept the following payment options:
\\n\\nIntechOpen will help you complete your payment safely and securely, keeping your personal, professional and financial information safe.
\\n\\n7. ONLINE PUBLICATION, PRINT AND DELIVERY OF THE BOOK
\\n\\nIntechOpen authors can choose whether to publish their book online only or opt for online and print editions. IntechOpen Compacts, Monographs and Edited Books will be published on www.intechopen.com. If ordered, print copies are delivered by DHL within 12 to 15 working days.
\\n\\nIf you feel that IntechOpen Compacts, Monographs or Edited Books are the right publishing format for your work, please fill out the publishing proposal form. For any specific queries related to the publishing process, or IntechOpen Compacts, Monographs & Edited Books in general, please contact us at book.department@intechopen.com
\\n"}]'},components:[{type:"htmlEditorComponent",content:'1. SEND YOUR PROPOSAL
\n\nPlease complete the publishing proposal form. The completed form should serve as an overview of your future Compacts, Monograph or Edited Book. Once submitted, your publishing proposal will be sent for evaluation, and a notice of acceptance or rejection will be sent within 10 to 30 working days from the date of submission.
\n\n2. SUBMIT YOUR MANUSCRIPT
\n\nAfter approval, you will proceed in submitting your full-length manuscript. 50-130 pages for compacts, 130-500 for Monographs & Edited Books.Your full-length manuscript must follow IntechOpen's Author Guidelines and comply with our publishing rules. Once the manuscript is submitted, but before it is forwarded for peer review, it will be screened for plagiarism.
\n\n3. PEER REVIEW RESULTS
\n\nExternal reviewers will evaluate your manuscript and provide you with their feedback. You may be asked to revise your draft, or parts of your draft, provide additional information and make any other necessary changes according to their comments and suggestions.
\n\n4. ACCEPTANCE AND PRICE QUOTE
\n\nIf the manuscript is formally accepted after peer review you will receive a formal Notice of Acceptance, and a price quote.
\n\nThe Open Access Publishing Fee of your IntechOpen Compacts, Monograph or Edited Book depends on the volume of the publication and includes: project management, editorial and peer review services, technical editing, language copyediting, cover design and book layout, book promotion and ISBN assignment.
\n\nWe will send you your price quote and after it has been accepted (by both the author and the publisher), both parties will sign a Statement of Work binding them to adhere to the agreed upon terms.
\n\nAt this step you will also be asked to accept the Copyright Agreement.
\n\n5. LANGUAGE COPYEDITING, TECHNICAL EDITING AND TYPESET PROOF
\n\nYour manuscript will be sent to Straive, a leader in content solution services, for language copyediting. You will then receive a typeset proof formatted in XML and available online in HTML and PDF to proofread and check for completeness. The first typeset proof of your manuscript is usually available 10 days after its original submission.
\n\nAfter we receive your proof corrections and a final typeset of the manuscript is approved, your manuscript is sent to our in house DTP department for technical formatting and online publication preparation.
\n\nAdditionally, you will be asked to provide a profile picture (face or chest-up portrait photograph) and a short summary of the book which is required for the book cover design.
\n\n6. INVOICE PAYMENT
\n\nThe invoice is generally paid by the author, the author’s institution or funder. The payment can be made by credit card from your Author Panel (one will be assigned to you at the beginning of the project), or via bank transfer as indicated on the invoice. We currently accept the following payment options:
\n\nIntechOpen will help you complete your payment safely and securely, keeping your personal, professional and financial information safe.
\n\n7. ONLINE PUBLICATION, PRINT AND DELIVERY OF THE BOOK
\n\nIntechOpen authors can choose whether to publish their book online only or opt for online and print editions. IntechOpen Compacts, Monographs and Edited Books will be published on www.intechopen.com. If ordered, print copies are delivered by DHL within 12 to 15 working days.
\n\nIf you feel that IntechOpen Compacts, Monographs or Edited Books are the right publishing format for your work, please fill out the publishing proposal form. For any specific queries related to the publishing process, or IntechOpen Compacts, Monographs & Edited Books in general, please contact us at book.department@intechopen.com
\n'}]},successStories:{items:[]},authorsAndEditors:{filterParams:{},profiles:[{id:"396",title:"Dr.",name:"Vedran",middleName:null,surname:"Kordic",slug:"vedran-kordic",fullName:"Vedran Kordic",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/396/images/7281_n.png",biography:"After obtaining his Master's degree in Mechanical Engineering he continued his education at the Vienna University of Technology where he obtained his PhD degree in 2004. He worked as a researcher at the Automation and Control Institute, Faculty of Electrical Engineering, Vienna University of Technology until 2008. His studies in robotics lead him not only to a PhD degree but also inspired him to co-found and build the International Journal of Advanced Robotic Systems - world's first Open Access journal in the field of robotics.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"441",title:"Ph.D.",name:"Jaekyu",middleName:null,surname:"Park",slug:"jaekyu-park",fullName:"Jaekyu Park",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/441/images/1881_n.jpg",biography:null,institutionString:null,institution:{name:"LG Corporation (South Korea)",country:{name:"Korea, South"}}},{id:"465",title:"Dr.",name:"Christian",middleName:null,surname:"Martens",slug:"christian-martens",fullName:"Christian Martens",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Rheinmetall (Germany)",country:{name:"Germany"}}},{id:"479",title:"Dr.",name:"Valentina",middleName:null,surname:"Colla",slug:"valentina-colla",fullName:"Valentina Colla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/479/images/358_n.jpg",biography:null,institutionString:null,institution:{name:"Sant'Anna School of Advanced Studies",country:{name:"Italy"}}},{id:"494",title:"PhD",name:"Loris",middleName:null,surname:"Nanni",slug:"loris-nanni",fullName:"Loris Nanni",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/494/images/system/494.jpg",biography:"Loris Nanni received his Master Degree cum laude on June-2002 from the University of Bologna, and the April 26th 2006 he received his Ph.D. in Computer Engineering at DEIS, University of Bologna. On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. His research interests include pattern recognition, bioinformatics, and biometric systems (fingerprint classification and recognition, signature verification, face recognition).",institutionString:null,institution:null},{id:"496",title:"Dr.",name:"Carlos",middleName:null,surname:"Leon",slug:"carlos-leon",fullName:"Carlos Leon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Seville",country:{name:"Spain"}}},{id:"512",title:"Dr.",name:"Dayang",middleName:null,surname:"Jawawi",slug:"dayang-jawawi",fullName:"Dayang Jawawi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Technology Malaysia",country:{name:"Malaysia"}}},{id:"528",title:"Dr.",name:"Kresimir",middleName:null,surname:"Delac",slug:"kresimir-delac",fullName:"Kresimir Delac",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/528/images/system/528.jpg",biography:"K. Delac received his B.Sc.E.E. degree in 2003 and is currentlypursuing a Ph.D. degree at the University of Zagreb, Faculty of Electrical Engineering andComputing. His current research interests are digital image analysis, pattern recognition andbiometrics.",institutionString:null,institution:{name:"University of Zagreb",country:{name:"Croatia"}}},{id:"557",title:"Dr.",name:"Andon",middleName:"Venelinov",surname:"Topalov",slug:"andon-topalov",fullName:"Andon Topalov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/557/images/1927_n.jpg",biography:"Dr. Andon V. Topalov received the MSc degree in Control Engineering from the Faculty of Information Systems, Technologies, and Automation at Moscow State University of Civil Engineering (MGGU) in 1979. He then received his PhD degree in Control Engineering from the Department of Automation and Remote Control at Moscow State Mining University (MGSU), Moscow, in 1984. From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. His current research interests are in the fields of intelligent control and robotics.",institutionString:null,institution:{name:"Technical University of Sofia",country:{name:"Bulgaria"}}},{id:"585",title:"Prof.",name:"Munir",middleName:null,surname:"Merdan",slug:"munir-merdan",fullName:"Munir Merdan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/585/images/system/585.jpg",biography:"Munir Merdan received the M.Sc. degree in mechanical engineering from the Technical University of Sarajevo, Bosnia and Herzegovina, in 2001, and the Ph.D. degree in electrical engineering from the Vienna University of Technology, Vienna, Austria, in 2009.Since 2005, he has been at the Automation and Control Institute, Vienna University of Technology, where he is currently a Senior Researcher. His research interests include the application of agent technology for achieving agile control in the manufacturing environment.",institutionString:null,institution:null},{id:"605",title:"Prof",name:"Dil",middleName:null,surname:"Hussain",slug:"dil-hussain",fullName:"Dil Hussain",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/605/images/system/605.jpg",biography:"Dr. Dil Muhammad Akbar Hussain is a professor of Electronics Engineering & Computer Science at the Department of Energy Technology, Aalborg University Denmark. Professor Akbar has a Master degree in Digital Electronics from Govt. College University, Lahore Pakistan and a P-hD degree in Control Engineering from the School of Engineering and Applied Sciences, University of Sussex United Kingdom. Aalborg University has Two Satellite Campuses, one in Copenhagen (Aalborg University Copenhagen) and the other in Esbjerg (Aalborg University Esbjerg).\n· He is a member of prestigious IEEE (Institute of Electrical and Electronics Engineers), and IAENG (International Association of Engineers) organizations. \n· He is the chief Editor of the Journal of Software Engineering.\n· He is the member of the Editorial Board of International Journal of Computer Science and Software Technology (IJCSST) and International Journal of Computer Engineering and Information Technology. \n· He is also the Editor of Communication in Computer and Information Science CCIS-20 by Springer.\n· Reviewer For Many Conferences\nHe is the lead person in making collaboration agreements between Aalborg University and many universities of Pakistan, for which the MOU’s (Memorandum of Understanding) have been signed.\nProfessor Akbar is working in Academia since 1990, he started his career as a Lab demonstrator/TA at the University of Sussex. After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. He has contributed in stochastic estimation of control area especially, in the Multiple Target Tracking and Interactive Multiple Model (IMM) research, Ball & Beam Control Problem, Robotics, Levitation Control. He has contributed in developing Algorithms for Fingerprint Matching, Computer Vision and Face Recognition. He has been supervising Pattern Recognition, Formal Languages and Distributed Processing projects for several years. He has reviewed many books on Management, Computer Science. Currently, he is an active and permanent reviewer for many international conferences and symposia and the program committee member for many international conferences.\nIn teaching he has taught the core computer science subjects like, Digital Design, Real Time Embedded System Programming, Operating Systems, Software Engineering, Data Structures, Databases, Compiler Construction. In the Engineering side, Digital Signal Processing, Computer Architecture, Electronics Devices, Digital Filtering and Engineering Management.\nApart from his Academic Interest and activities he loves sport especially, Cricket, Football, Snooker and Squash. He plays cricket for Esbjerg city in the second division team as an opener wicket keeper batsman. He is a very good player of squash but has not played squash since his arrival in Denmark.",institutionString:null,institution:null},{id:"611",title:"Prof.",name:"T",middleName:null,surname:"Nagarajan",slug:"t-nagarajan",fullName:"T Nagarajan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universiti Teknologi Petronas",country:{name:"Malaysia"}}}],filtersByRegion:[{group:"region",caption:"North America",value:1,count:13389},{group:"region",caption:"Middle and South America",value:2,count:11662},{group:"region",caption:"Africa",value:3,count:4168},{group:"region",caption:"Asia",value:4,count:22333},{group:"region",caption:"Australia and Oceania",value:5,count:2019},{group:"region",caption:"Europe",value:6,count:33644}],offset:12,limit:12,total:135278},chapterEmbeded:{data:{}},editorApplication:{success:null,errors:{}},ofsBooks:{filterParams:{},books:[{type:"book",id:"9985",title:"Geostatistics",subtitle:null,isOpenForSubmission:!0,hash:"423cb3896195a618c4acb493ce4fd23d",slug:null,bookSignature:"Prof. Jeffrey M. Yarus, Dr. Marko Maucec, Dr. Timothy C. Coburn and Associate Prof. Michael Pyrcz",coverURL:"https://cdn.intechopen.com/books/images_new/9985.jpg",editedByType:null,editors:[{id:"78011",title:"Prof.",name:"Jeffrey M.",surname:"Yarus",slug:"jeffrey-m.-yarus",fullName:"Jeffrey M. Yarus"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10845",title:"Marine Ecosystems - Biodiversity, Ecosystem Services and Human Impacts",subtitle:null,isOpenForSubmission:!0,hash:"727e7eb3d4ba529ec5eb4f150e078523",slug:null,bookSignature:"Dr. Ana M.M. Marta Gonçalves",coverURL:"https://cdn.intechopen.com/books/images_new/10845.jpg",editedByType:null,editors:[{id:"320124",title:"Dr.",name:"Ana M.M.",surname:"Gonçalves",slug:"ana-m.m.-goncalves",fullName:"Ana M.M. Gonçalves"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11027",title:"Basics of Hypoglycemia",subtitle:null,isOpenForSubmission:!0,hash:"98ebc1e36d02be82c204b8fd5d24f97a",slug:null,bookSignature:"Dr. Alok Raghav",coverURL:"https://cdn.intechopen.com/books/images_new/11027.jpg",editedByType:null,editors:[{id:"334465",title:"Dr.",name:"Alok",surname:"Raghav",slug:"alok-raghav",fullName:"Alok Raghav"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11124",title:"Next-Generation Textiles",subtitle:null,isOpenForSubmission:!0,hash:"093f9e26bb829b8d414d13626aea1086",slug:null,bookSignature:"Dr. Hassan Ibrahim",coverURL:"https://cdn.intechopen.com/books/images_new/11124.jpg",editedByType:null,editors:[{id:"90645",title:"Dr.",name:"Hassan",surname:"Ibrahim",slug:"hassan-ibrahim",fullName:"Hassan Ibrahim"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11369",title:"RNA Viruses Infection",subtitle:null,isOpenForSubmission:!0,hash:"52f8a3a1486912beae40b34ac557fed3",slug:null,bookSignature:"Ph.D. Yogendra Shah",coverURL:"https://cdn.intechopen.com/books/images_new/11369.jpg",editedByType:null,editors:[{id:"278914",title:"Ph.D.",name:"Yogendra",surname:"Shah",slug:"yogendra-shah",fullName:"Yogendra Shah"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11433",title:"Human Migration in the Last Three Centuries",subtitle:null,isOpenForSubmission:!0,hash:"9836df9e82aa9f82e3852a60204909a8",slug:null,bookSignature:"Dr. Ingrid Muenstermann",coverURL:"https://cdn.intechopen.com/books/images_new/11433.jpg",editedByType:null,editors:[{id:"77112",title:"Dr.",name:"Ingrid",surname:"Muenstermann",slug:"ingrid-muenstermann",fullName:"Ingrid Muenstermann"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11438",title:"Fake News in the Era of Global Crises",subtitle:null,isOpenForSubmission:!0,hash:"5f61f975031e13ee705d8b5853f1aa58",slug:null,bookSignature:"Dr. David Eller",coverURL:"https://cdn.intechopen.com/books/images_new/11438.jpg",editedByType:null,editors:[{id:"476616",title:"Dr.",name:"Jack",surname:"Eller",slug:"jack-eller",fullName:"Jack Eller"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11447",title:"Swarm Intelligence - Recent Advances and Current Applications",subtitle:null,isOpenForSubmission:!0,hash:"f68e3c3430a74fc7a7eb97f6ea2bb42e",slug:null,bookSignature:"Dr. Marco Antonio Aceves Fernandez",coverURL:"https://cdn.intechopen.com/books/images_new/11447.jpg",editedByType:null,editors:[{id:"24555",title:"Dr.",name:"Marco Antonio",surname:"Aceves Fernandez",slug:"marco-antonio-aceves-fernandez",fullName:"Marco Antonio Aceves Fernandez"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11452",title:"Cryopreservation - Applications and Challenges",subtitle:null,isOpenForSubmission:!0,hash:"a6c3fd4384ff7deeab32fc82722c60e0",slug:null,bookSignature:"Dr. Marian Quain",coverURL:"https://cdn.intechopen.com/books/images_new/11452.jpg",editedByType:null,editors:[{id:"300385",title:"Dr.",name:"Marian",surname:"Quain",slug:"marian-quain",fullName:"Marian Quain"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11456",title:"Autonomous Mobile Mapping Robots",subtitle:null,isOpenForSubmission:!0,hash:"405e1f7c0ef62700f4d590722cf428be",slug:null,bookSignature:"Dr. Janusz Bȩdkowski",coverURL:"https://cdn.intechopen.com/books/images_new/11456.jpg",editedByType:null,editors:[{id:"63695",title:"Dr.",name:"Janusz",surname:"Bȩdkowski",slug:"janusz-bdkowski",fullName:"Janusz Bȩdkowski"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11459",title:"Soft Robotics - Recent Advances and Applications",subtitle:null,isOpenForSubmission:!0,hash:"06e947238d5d4ea1162509a5d66de887",slug:null,bookSignature:"Dr. Mahmut Reyhanoglu",coverURL:"https://cdn.intechopen.com/books/images_new/11459.jpg",editedByType:null,editors:[{id:"15068",title:"Dr.",name:"Mahmut",surname:"Reyhanoglu",slug:"mahmut-reyhanoglu",fullName:"Mahmut Reyhanoglu"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11464",title:"Carbon Nanotubes - Recent Advances, New Perspectives and Potential Applications",subtitle:null,isOpenForSubmission:!0,hash:"ce526ec78ed00c4f5f08ffb4548ff388",slug:null,bookSignature:"Prof. Mohammed Muzibur Rahman, Dr. Abdullah Mohammed Ahmed Asiri and Prof. Mohammad Asaduzzaman Chowdhury",coverURL:"https://cdn.intechopen.com/books/images_new/11464.jpg",editedByType:null,editors:[{id:"24438",title:"Prof.",name:"Mohammed Muzibur",surname:"Rahman",slug:"mohammed-muzibur-rahman",fullName:"Mohammed Muzibur Rahman"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],filtersByTopic:[{group:"topic",caption:"Agricultural and Biological Sciences",value:5,count:22},{group:"topic",caption:"Biochemistry, Genetics and Molecular Biology",value:6,count:6},{group:"topic",caption:"Business, Management and Economics",value:7,count:4},{group:"topic",caption:"Chemistry",value:8,count:15},{group:"topic",caption:"Computer and Information Science",value:9,count:18},{group:"topic",caption:"Earth and Planetary Sciences",value:10,count:8},{group:"topic",caption:"Engineering",value:11,count:37},{group:"topic",caption:"Environmental Sciences",value:12,count:5},{group:"topic",caption:"Immunology and Microbiology",value:13,count:8},{group:"topic",caption:"Materials Science",value:14,count:15},{group:"topic",caption:"Mathematics",value:15,count:8},{group:"topic",caption:"Medicine",value:16,count:62},{group:"topic",caption:"Nanotechnology and Nanomaterials",value:17,count:2},{group:"topic",caption:"Neuroscience",value:18,count:2},{group:"topic",caption:"Pharmacology, Toxicology and Pharmaceutical Science",value:19,count:7},{group:"topic",caption:"Physics",value:20,count:5},{group:"topic",caption:"Psychology",value:21,count:5},{group:"topic",caption:"Robotics",value:22,count:2},{group:"topic",caption:"Social Sciences",value:23,count:8},{group:"topic",caption:"Veterinary Medicine and Science",value:25,count:2}],offset:12,limit:12,total:468},popularBooks:{featuredBooks:[{type:"book",id:"7827",title:"Interpersonal Relationships",subtitle:null,isOpenForSubmission:!1,hash:"ebf41f4d17c75010eb3294cc8cac3d47",slug:"interpersonal-relationships",bookSignature:"Martha Peaslee Levine",coverURL:"https://cdn.intechopen.com/books/images_new/7827.jpg",editors:[{id:"186919",title:"Dr.",name:"Martha",middleName:null,surname:"Peaslee Levine",slug:"martha-peaslee-levine",fullName:"Martha Peaslee Levine"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10808",title:"Current Concepts in Dental Implantology",subtitle:"From Science to Clinical Research",isOpenForSubmission:!1,hash:"4af8830e463f89c57515c2da2b9777b0",slug:"current-concepts-in-dental-implantology-from-science-to-clinical-research",bookSignature:"Dragana Gabrić and Marko Vuletić",coverURL:"https://cdn.intechopen.com/books/images_new/10808.jpg",editors:[{id:"26946",title:"Prof.",name:"Dragana",middleName:null,surname:"Gabrić",slug:"dragana-gabric",fullName:"Dragana Gabrić"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10796",title:"Extracellular Vesicles",subtitle:"Role in Diseases, Pathogenesis and Therapy",isOpenForSubmission:!1,hash:"eb5407fcf93baff7bca3fae5640153a2",slug:"extracellular-vesicles-role-in-diseases-pathogenesis-and-therapy",bookSignature:"Manash K. Paul",coverURL:"https://cdn.intechopen.com/books/images_new/10796.jpg",editors:[{id:"319365",title:"Assistant Prof.",name:"Manash K.",middleName:null,surname:"Paul",slug:"manash-k.-paul",fullName:"Manash K. Paul"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10908",title:"Advances in Decision Making",subtitle:null,isOpenForSubmission:!1,hash:"126486f7f91e18e2e3539a32c38be7b1",slug:"advances-in-decision-making",bookSignature:"Fausto Pedro García Márquez",coverURL:"https://cdn.intechopen.com/books/images_new/10908.jpg",editors:[{id:"22844",title:"Prof.",name:"Fausto Pedro",middleName:null,surname:"García Márquez",slug:"fausto-pedro-garcia-marquez",fullName:"Fausto Pedro García Márquez"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"95",title:"Applications and Experiences of Quality Control",subtitle:null,isOpenForSubmission:!1,hash:"4bcb22b1eee68210a977a97d5a0f363a",slug:"applications-and-experiences-of-quality-control",bookSignature:"Ognyan Ivanov",coverURL:"https://cdn.intechopen.com/books/images_new/95.jpg",editors:[{id:"22230",title:"Prof.",name:"Ognyan",middleName:null,surname:"Ivanov",slug:"ognyan-ivanov",fullName:"Ognyan Ivanov"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"2160",title:"MATLAB",subtitle:"A Fundamental Tool for Scientific Computing and Engineering Applications - Volume 1",isOpenForSubmission:!1,hash:"dd9c658341fbd264ed4f8d9e6aa8ca29",slug:"matlab-a-fundamental-tool-for-scientific-computing-and-engineering-applications-volume-1",bookSignature:"Vasilios N. Katsikis",coverURL:"https://cdn.intechopen.com/books/images_new/2160.jpg",editors:[{id:"12289",title:"Prof.",name:"Vasilios",middleName:"N.",surname:"Katsikis",slug:"vasilios-katsikis",fullName:"Vasilios Katsikis"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"3560",title:"Advances in Landscape Architecture",subtitle:null,isOpenForSubmission:!1,hash:"a20614517ec5f7e91188fe8e42832138",slug:"advances-in-landscape-architecture",bookSignature:"Murat Özyavuz",coverURL:"https://cdn.intechopen.com/books/images_new/3560.jpg",editors:[{id:"93073",title:"Dr.",name:"Murat",middleName:null,surname:"Ozyavuz",slug:"murat-ozyavuz",fullName:"Murat Ozyavuz"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10739",title:"Global Decline of Insects",subtitle:null,isOpenForSubmission:!1,hash:"543783652b9092962a8fa4bed38eeb17",slug:"global-decline-of-insects",bookSignature:"Hamadttu Abdel Farag El-Shafie",coverURL:"https://cdn.intechopen.com/books/images_new/10739.jpg",editors:[{id:"192142",title:"Dr.",name:"Hamadttu",middleName:null,surname:"Abdel Farag El-Shafie",slug:"hamadttu-abdel-farag-el-shafie",fullName:"Hamadttu Abdel Farag El-Shafie"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10911",title:"Higher Education",subtitle:"New Approaches to Accreditation, Digitalization, and Globalization in the Age of Covid",isOpenForSubmission:!1,hash:"223a02337498e535e967174c1f648fbc",slug:"higher-education-new-approaches-to-accreditation-digitalization-and-globalization-in-the-age-of-covid",bookSignature:"Lee Waller and Sharon Waller",coverURL:"https://cdn.intechopen.com/books/images_new/10911.jpg",editors:[{id:"263301",title:"Dr.",name:"Lee",middleName:null,surname:"Waller",slug:"lee-waller",fullName:"Lee Waller"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"3568",title:"Recent Advances in Plant in vitro Culture",subtitle:null,isOpenForSubmission:!1,hash:"830bbb601742c85a3fb0eeafe1454c43",slug:"recent-advances-in-plant-in-vitro-culture",bookSignature:"Annarita Leva and Laura M. R. Rinaldi",coverURL:"https://cdn.intechopen.com/books/images_new/3568.jpg",editors:[{id:"142145",title:"Dr.",name:"Annarita",middleName:null,surname:"Leva",slug:"annarita-leva",fullName:"Annarita Leva"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"3737",title:"MATLAB",subtitle:"Modelling, Programming and Simulations",isOpenForSubmission:!1,hash:null,slug:"matlab-modelling-programming-and-simulations",bookSignature:"Emilson Pereira Leite",coverURL:"https://cdn.intechopen.com/books/images_new/3737.jpg",editors:[{id:"12051",title:"Prof.",name:"Emilson",middleName:null,surname:"Pereira Leite",slug:"emilson-pereira-leite",fullName:"Emilson Pereira Leite"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"1770",title:"Gel Electrophoresis",subtitle:"Principles and Basics",isOpenForSubmission:!1,hash:"279701f6c802cf02deef45103e0611ff",slug:"gel-electrophoresis-principles-and-basics",bookSignature:"Sameh Magdeldin",coverURL:"https://cdn.intechopen.com/books/images_new/1770.jpg",editors:[{id:"123648",title:"Dr.",name:"Sameh",middleName:null,surname:"Magdeldin",slug:"sameh-magdeldin",fullName:"Sameh Magdeldin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],offset:12,limit:12,total:4797},hotBookTopics:{hotBooks:[],offset:0,limit:12,total:null},publish:{},publishingProposal:{success:null,errors:{}},books:{featuredBooks:[{type:"book",id:"7827",title:"Interpersonal Relationships",subtitle:null,isOpenForSubmission:!1,hash:"ebf41f4d17c75010eb3294cc8cac3d47",slug:"interpersonal-relationships",bookSignature:"Martha Peaslee Levine",coverURL:"https://cdn.intechopen.com/books/images_new/7827.jpg",publishedDate:"July 27th 2022",numberOfDownloads:7175,editors:[{id:"186919",title:"Dr.",name:"Martha",middleName:null,surname:"Peaslee Levine",slug:"martha-peaslee-levine",fullName:"Martha Peaslee Levine"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10808",title:"Current Concepts in Dental Implantology",subtitle:"From Science to Clinical Research",isOpenForSubmission:!1,hash:"4af8830e463f89c57515c2da2b9777b0",slug:"current-concepts-in-dental-implantology-from-science-to-clinical-research",bookSignature:"Dragana Gabrić and Marko Vuletić",coverURL:"https://cdn.intechopen.com/books/images_new/10808.jpg",publishedDate:"July 27th 2022",numberOfDownloads:1981,editors:[{id:"26946",title:"Prof.",name:"Dragana",middleName:null,surname:"Gabrić",slug:"dragana-gabric",fullName:"Dragana Gabrić"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10796",title:"Extracellular Vesicles",subtitle:"Role in Diseases, Pathogenesis and Therapy",isOpenForSubmission:!1,hash:"eb5407fcf93baff7bca3fae5640153a2",slug:"extracellular-vesicles-role-in-diseases-pathogenesis-and-therapy",bookSignature:"Manash K. Paul",coverURL:"https://cdn.intechopen.com/books/images_new/10796.jpg",publishedDate:"July 20th 2022",numberOfDownloads:2308,editors:[{id:"319365",title:"Assistant Prof.",name:"Manash K.",middleName:null,surname:"Paul",slug:"manash-k.-paul",fullName:"Manash K. Paul"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10908",title:"Advances in Decision Making",subtitle:null,isOpenForSubmission:!1,hash:"126486f7f91e18e2e3539a32c38be7b1",slug:"advances-in-decision-making",bookSignature:"Fausto Pedro García Márquez",coverURL:"https://cdn.intechopen.com/books/images_new/10908.jpg",publishedDate:"July 27th 2022",numberOfDownloads:1473,editors:[{id:"22844",title:"Prof.",name:"Fausto Pedro",middleName:null,surname:"García Márquez",slug:"fausto-pedro-garcia-marquez",fullName:"Fausto Pedro García Márquez"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"95",title:"Applications and Experiences of Quality Control",subtitle:null,isOpenForSubmission:!1,hash:"4bcb22b1eee68210a977a97d5a0f363a",slug:"applications-and-experiences-of-quality-control",bookSignature:"Ognyan Ivanov",coverURL:"https://cdn.intechopen.com/books/images_new/95.jpg",publishedDate:"April 26th 2011",numberOfDownloads:318571,editors:[{id:"22230",title:"Prof.",name:"Ognyan",middleName:null,surname:"Ivanov",slug:"ognyan-ivanov",fullName:"Ognyan Ivanov"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"2160",title:"MATLAB",subtitle:"A Fundamental Tool for Scientific Computing and Engineering Applications - Volume 1",isOpenForSubmission:!1,hash:"dd9c658341fbd264ed4f8d9e6aa8ca29",slug:"matlab-a-fundamental-tool-for-scientific-computing-and-engineering-applications-volume-1",bookSignature:"Vasilios N. Katsikis",coverURL:"https://cdn.intechopen.com/books/images_new/2160.jpg",publishedDate:"September 26th 2012",numberOfDownloads:271836,editors:[{id:"12289",title:"Prof.",name:"Vasilios",middleName:"N.",surname:"Katsikis",slug:"vasilios-katsikis",fullName:"Vasilios Katsikis"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"3560",title:"Advances in Landscape Architecture",subtitle:null,isOpenForSubmission:!1,hash:"a20614517ec5f7e91188fe8e42832138",slug:"advances-in-landscape-architecture",bookSignature:"Murat Özyavuz",coverURL:"https://cdn.intechopen.com/books/images_new/3560.jpg",publishedDate:"July 1st 2013",numberOfDownloads:243450,editors:[{id:"93073",title:"Dr.",name:"Murat",middleName:null,surname:"Ozyavuz",slug:"murat-ozyavuz",fullName:"Murat Ozyavuz"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10739",title:"Global Decline of Insects",subtitle:null,isOpenForSubmission:!1,hash:"543783652b9092962a8fa4bed38eeb17",slug:"global-decline-of-insects",bookSignature:"Hamadttu Abdel Farag El-Shafie",coverURL:"https://cdn.intechopen.com/books/images_new/10739.jpg",publishedDate:"July 20th 2022",numberOfDownloads:1582,editors:[{id:"192142",title:"Dr.",name:"Hamadttu",middleName:null,surname:"Abdel Farag El-Shafie",slug:"hamadttu-abdel-farag-el-shafie",fullName:"Hamadttu Abdel Farag El-Shafie"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10911",title:"Higher Education",subtitle:"New Approaches to Accreditation, Digitalization, and Globalization in the Age of Covid",isOpenForSubmission:!1,hash:"223a02337498e535e967174c1f648fbc",slug:"higher-education-new-approaches-to-accreditation-digitalization-and-globalization-in-the-age-of-covid",bookSignature:"Lee Waller and Sharon Waller",coverURL:"https://cdn.intechopen.com/books/images_new/10911.jpg",publishedDate:"July 13th 2022",numberOfDownloads:2082,editors:[{id:"263301",title:"Dr.",name:"Lee",middleName:null,surname:"Waller",slug:"lee-waller",fullName:"Lee Waller"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"3568",title:"Recent Advances in Plant in vitro Culture",subtitle:null,isOpenForSubmission:!1,hash:"830bbb601742c85a3fb0eeafe1454c43",slug:"recent-advances-in-plant-in-vitro-culture",bookSignature:"Annarita Leva and Laura M. R. Rinaldi",coverURL:"https://cdn.intechopen.com/books/images_new/3568.jpg",publishedDate:"October 17th 2012",numberOfDownloads:256294,editors:[{id:"142145",title:"Dr.",name:"Annarita",middleName:null,surname:"Leva",slug:"annarita-leva",fullName:"Annarita Leva"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],latestBooks:[{type:"book",id:"10808",title:"Current Concepts in Dental Implantology",subtitle:"From Science to Clinical Research",isOpenForSubmission:!1,hash:"4af8830e463f89c57515c2da2b9777b0",slug:"current-concepts-in-dental-implantology-from-science-to-clinical-research",bookSignature:"Dragana Gabrić and Marko Vuletić",coverURL:"https://cdn.intechopen.com/books/images_new/10808.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"26946",title:"Prof.",name:"Dragana",middleName:null,surname:"Gabrić",slug:"dragana-gabric",fullName:"Dragana Gabrić"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11328",title:"Botulinum Toxin",subtitle:"Recent Topics and Applications",isOpenForSubmission:!1,hash:"7dd05a316001cef143e209eda51387a7",slug:"botulinum-toxin-recent-topics-and-applications",bookSignature:"Suna Sabuncuoglu",coverURL:"https://cdn.intechopen.com/books/images_new/11328.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"270856",title:"Associate Prof.",name:"Suna",middleName:null,surname:"Sabuncuoglu",slug:"suna-sabuncuoglu",fullName:"Suna Sabuncuoglu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11085",title:"Polycystic Ovary Syndrome",subtitle:"Functional Investigation and Clinical Application",isOpenForSubmission:!1,hash:"3066dd3ff29e1fac072fd60b08d4d3e7",slug:"polycystic-ovary-syndrome-functional-investigation-and-clinical-application",bookSignature:"Zhengchao Wang",coverURL:"https://cdn.intechopen.com/books/images_new/11085.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"204883",title:"Dr.",name:"Zhengchao",middleName:null,surname:"Wang",slug:"zhengchao-wang",fullName:"Zhengchao Wang"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10833",title:"Tumor Angiogenesis and Modulators",subtitle:null,isOpenForSubmission:!1,hash:"f29b575c46128b2da061ef7f9bd1070b",slug:"tumor-angiogenesis-and-modulators",bookSignature:"Ke Xu",coverURL:"https://cdn.intechopen.com/books/images_new/10833.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"59529",title:"Dr.",name:"Ke",middleName:null,surname:"Xu",slug:"ke-xu",fullName:"Ke Xu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11356",title:"Molecular Cloning",subtitle:null,isOpenForSubmission:!1,hash:"671c629dd86e97f0fb467b9e70e92296",slug:"molecular-cloning",bookSignature:"Sadık Dincer, Hatice Aysun Mercimek Takcı and Melis Sumengen Ozdenef",coverURL:"https://cdn.intechopen.com/books/images_new/11356.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"188141",title:"Prof.",name:"Sadik",middleName:null,surname:"Dincer",slug:"sadik-dincer",fullName:"Sadik Dincer"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7827",title:"Interpersonal Relationships",subtitle:null,isOpenForSubmission:!1,hash:"ebf41f4d17c75010eb3294cc8cac3d47",slug:"interpersonal-relationships",bookSignature:"Martha Peaslee Levine",coverURL:"https://cdn.intechopen.com/books/images_new/7827.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"186919",title:"Dr.",name:"Martha",middleName:null,surname:"Peaslee Levine",slug:"martha-peaslee-levine",fullName:"Martha Peaslee Levine"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10908",title:"Advances in Decision Making",subtitle:null,isOpenForSubmission:!1,hash:"126486f7f91e18e2e3539a32c38be7b1",slug:"advances-in-decision-making",bookSignature:"Fausto Pedro García Márquez",coverURL:"https://cdn.intechopen.com/books/images_new/10908.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"22844",title:"Prof.",name:"Fausto Pedro",middleName:null,surname:"García Márquez",slug:"fausto-pedro-garcia-marquez",fullName:"Fausto Pedro García Márquez"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10669",title:"Corrosion",subtitle:"Fundamentals and Protection Mechanisms",isOpenForSubmission:!1,hash:"4a76d54f8a40fc2e7002a8d13fd617c1",slug:"corrosion-fundamentals-and-protection-mechanisms",bookSignature:"Fahmina Zafar, Anujit Ghosal and Eram Sharmin",coverURL:"https://cdn.intechopen.com/books/images_new/10669.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"89672",title:"Dr.",name:"Fahmina",middleName:null,surname:"Zafar",slug:"fahmina-zafar",fullName:"Fahmina Zafar"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10677",title:"Advanced Topics of Topology",subtitle:null,isOpenForSubmission:!1,hash:"bf964c52f9e653fac20a7fcab58070e5",slug:"advanced-topics-of-topology",bookSignature:"Francisco Bulnes",coverURL:"https://cdn.intechopen.com/books/images_new/10677.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"92918",title:"Dr.",name:"Francisco",middleName:null,surname:"Bulnes",slug:"francisco-bulnes",fullName:"Francisco Bulnes"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11195",title:"Recent Advances in Biometrics",subtitle:null,isOpenForSubmission:!1,hash:"2d32e33e0f499cb5241734bb75dd2a83",slug:"recent-advances-in-biometrics",bookSignature:"Muhammad Sarfraz",coverURL:"https://cdn.intechopen.com/books/images_new/11195.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},subject:{topic:{id:"610",title:"Numerical Computing",slug:"numerical-computing",parent:{id:"95",title:"Numerical Analysis and Scientific Computing",slug:"numerical-analysis-and-scientific-computing"},numberOfBooks:14,numberOfSeries:0,numberOfAuthorsAndEditors:553,numberOfWosCitations:590,numberOfCrossrefCitations:337,numberOfDimensionsCitations:790,videoUrl:null,fallbackUrl:null,description:null},booksByTopicFilter:{topicId:"610",sort:"-publishedDate",limit:12,offset:0},booksByTopicCollection:[{type:"book",id:"6281",title:"Finite Element Method",subtitle:"Simulation, Numerical Analysis and Solution Techniques",isOpenForSubmission:!1,hash:"9dde55be38d54e4593f142a4a5642f58",slug:"finite-element-method-simulation-numerical-analysis-and-solution-techniques",bookSignature:"Răzvan Păcurar",coverURL:"https://cdn.intechopen.com/books/images_new/6281.jpg",editedByType:"Edited by",editors:[{id:"179623",title:"Dr.",name:"Răzvan",middleName:null,surname:"Păcurar",slug:"razvan-pacurar",fullName:"Răzvan Păcurar"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"4538",title:"Fourier Transform",subtitle:"Signal Processing and Physical Sciences",isOpenForSubmission:!1,hash:"4dfc78ab6a3abc41b6136a4a9e2b8afa",slug:"fourier-transform-signal-processing-and-physical-sciences",bookSignature:"Salih Mohammed Salih",coverURL:"https://cdn.intechopen.com/books/images_new/4538.jpg",editedByType:"Edited by",editors:[{id:"111691",title:"Dr.Ing.",name:"Salih",middleName:"Mohammed",surname:"Salih",slug:"salih-salih",fullName:"Salih Salih"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3832",title:"Computational and Numerical Simulations",subtitle:null,isOpenForSubmission:!1,hash:"44c51ee67bb45c4a080ece19bd0f6a08",slug:"computational-and-numerical-simulations",bookSignature:"Jan Awrejcewicz",coverURL:"https://cdn.intechopen.com/books/images_new/3832.jpg",editedByType:"Edited by",editors:[{id:"68338",title:"Prof.",name:"Jan",middleName:null,surname:"Awrejcewicz",slug:"jan-awrejcewicz",fullName:"Jan Awrejcewicz"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2207",title:"Numerical Simulation",subtitle:"From Theory to Industry",isOpenForSubmission:!1,hash:"1a2002ed6e06f8cb36ad55b57aab57e5",slug:"numerical-simulation-from-theory-to-industry",bookSignature:"Mykhaylo Andriychuk",coverURL:"https://cdn.intechopen.com/books/images_new/2207.jpg",editedByType:"Edited by",editors:[{id:"57755",title:"Dr.",name:"Mykhaylo",middleName:"I.",surname:"Andriychuk",slug:"mykhaylo-andriychuk",fullName:"Mykhaylo Andriychuk"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2141",title:"Finite Volume Method",subtitle:"Powerful Means of Engineering Design",isOpenForSubmission:!1,hash:"0664f831a342fdbcf1fe496e9885f161",slug:"finite-volume-method-powerful-means-of-engineering-design",bookSignature:"Radostina Petrova",coverURL:"https://cdn.intechopen.com/books/images_new/2141.jpg",editedByType:"Edited by",editors:[{id:"118470",title:"PhD.",name:"Radostina",middleName:"Vasileva",surname:"Petrova",slug:"radostina-petrova",fullName:"Radostina Petrova"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2274",title:"Fuzzy Logic",subtitle:"Algorithms, Techniques and Implementations",isOpenForSubmission:!1,hash:"116c1be2754eb60e90b4ad3642546291",slug:"fuzzy-logic-algorithms-techniques-and-implementations",bookSignature:"Elmer P. Dadios",coverURL:"https://cdn.intechopen.com/books/images_new/2274.jpg",editedByType:"Edited by",editors:[{id:"111683",title:"Prof.",name:"Elmer P.",middleName:"P.",surname:"Dadios",slug:"elmer-p.-dadios",fullName:"Elmer P. Dadios"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1988",title:"Applied Computational Fluid Dynamics",subtitle:null,isOpenForSubmission:!1,hash:"31dcd7458d945041cbdfec7adbc2fa11",slug:"applied-computational-fluid-dynamics",bookSignature:"Hyoung Woo Oh",coverURL:"https://cdn.intechopen.com/books/images_new/1988.jpg",editedByType:"Edited by",editors:[{id:"63199",title:"Prof.",name:"Hyoung Woo",middleName:null,surname:"Oh",slug:"hyoung-woo-oh",fullName:"Hyoung Woo Oh"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1989",title:"Fluid Dynamics, Computational Modeling and Applications",subtitle:null,isOpenForSubmission:!1,hash:"e7f43d55285a6a3447c62c066f072e8b",slug:"fluid-dynamics-computational-modeling-and-applications",bookSignature:"L. Hector Juarez",coverURL:"https://cdn.intechopen.com/books/images_new/1989.jpg",editedByType:"Edited by",editors:[{id:"65861",title:"Dr.",name:"L. Hector",middleName:null,surname:"Juarez",slug:"l.-hector-juarez",fullName:"L. Hector Juarez"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2855",title:"Computational Modelling of Multi-scale Solute Dispersion in Porous Media",subtitle:"An Approach Based on Stochastic Calculus",isOpenForSubmission:!1,hash:"cda3a5c9b15c12fa429485993422ef66",slug:"computational-modelling-of-multi-scale-solute-dispersion-in-porous-media-an-approach-based-on-stochastic-calculus",bookSignature:"Don Kulasiri",coverURL:"https://cdn.intechopen.com/books/images_new/2855.jpg",editedByType:"Authored by",editors:[{id:"28400",title:"Prof.",name:"Don",middleName:null,surname:"Kulasiri",slug:"don-kulasiri",fullName:"Don Kulasiri"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"3",chapterContentType:"chapter",authoredCaption:"Authored by"}},{type:"book",id:"532",title:"Two Phase Flow, Phase Change and Numerical Modeling",subtitle:null,isOpenForSubmission:!1,hash:"331fe87b8edf0e8adf7e6086e4eea81c",slug:"two-phase-flow-phase-change-and-numerical-modeling",bookSignature:"Amimul Ahsan",coverURL:"https://cdn.intechopen.com/books/images_new/532.jpg",editedByType:"Edited by",editors:[{id:"36782",title:"Associate Prof.",name:"Amimul",middleName:null,surname:"Ahsan",slug:"amimul-ahsan",fullName:"Amimul Ahsan"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1363",title:"Numerical Analysis",subtitle:"Theory and Application",isOpenForSubmission:!1,hash:"509ce23e2dae5d72c14be89bd9b75004",slug:"numerical-analysis-theory-and-application",bookSignature:"Jan Awrejcewicz",coverURL:"https://cdn.intechopen.com/books/images_new/1363.jpg",editedByType:"Edited by",editors:[{id:"68338",title:"Prof.",name:"Jan",middleName:null,surname:"Awrejcewicz",slug:"jan-awrejcewicz",fullName:"Jan Awrejcewicz"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"161",title:"Computational Fluid Dynamics",subtitle:"Technologies and Applications",isOpenForSubmission:!1,hash:"d636946634ddf4e48b6e9bc6a0cd615a",slug:"computational-fluid-dynamics-technologies-and-applications",bookSignature:"Igor V. Minin and Oleg V. Minin",coverURL:"https://cdn.intechopen.com/books/images_new/161.jpg",editedByType:"Edited by",editors:[{id:"3712",title:"Prof.",name:"Oleg",middleName:null,surname:"Minin",slug:"oleg-minin",fullName:"Oleg Minin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],booksByTopicTotal:14,seriesByTopicCollection:[],seriesByTopicTotal:0,mostCitedChapters:[{id:"19443",doi:"10.5772/25128",title:"Modelling Friction Contacts in Structural Dynamics and its Application to Turbine Bladed Disks",slug:"modelling-friction-contacts-in-structural-dynamics-and-its-application-to-turbine-bladed-disks",totalDownloads:3650,totalCrossrefCites:3,totalDimensionsCites:39,abstract:null,book:{id:"1363",slug:"numerical-analysis-theory-and-application",title:"Numerical Analysis",fullTitle:"Numerical Analysis - Theory and Application"},signatures:"Christian Maria Firrone and Stefano Zucca",authors:[{id:"62033",title:"Dr.",name:"Christian Maria",middleName:null,surname:"Firrone",slug:"christian-maria-firrone",fullName:"Christian Maria Firrone"},{id:"62043",title:"Dr.",name:"Stefano",middleName:null,surname:"Zucca",slug:"stefano-zucca",fullName:"Stefano Zucca"}]},{id:"16384",doi:"10.5772/23496",title:"CFD for Characterizing Standard and Single-use Stirred Cell Culture Bioreactors",slug:"cfd-for-characterizing-standard-and-single-use-stirred-cell-culture-bioreactors",totalDownloads:7154,totalCrossrefCites:3,totalDimensionsCites:36,abstract:null,book:{id:"161",slug:"computational-fluid-dynamics-technologies-and-applications",title:"Computational Fluid Dynamics",fullTitle:"Computational Fluid Dynamics Technologies and Applications"},signatures:"Stephan C. Kaiser, Christian Löffelholz, Sören Werner and Dieter Eibl",authors:[{id:"52219",title:"MSc",name:"Stephan C.",middleName:null,surname:"Kaiser",slug:"stephan-c.-kaiser",fullName:"Stephan C. Kaiser"},{id:"52439",title:"MSc.",name:"Sören",middleName:null,surname:"Werner",slug:"soren-werner",fullName:"Sören Werner"},{id:"52440",title:"MSc.",name:"Christian",middleName:null,surname:"Löffelholz",slug:"christian-loffelholz",fullName:"Christian Löffelholz"},{id:"52441",title:"Prof.",name:"Dieter",middleName:null,surname:"Eibl",slug:"dieter-eibl",fullName:"Dieter Eibl"}]},{id:"19452",doi:"10.5772/24111",title:"Numerical Simulation for Vehicle Powertrain Development",slug:"numerical-simulation-for-vehicle-powertrain-development",totalDownloads:6406,totalCrossrefCites:20,totalDimensionsCites:34,abstract:null,book:{id:"1363",slug:"numerical-analysis-theory-and-application",title:"Numerical Analysis",fullTitle:"Numerical Analysis - Theory and Application"},signatures:"Federico Millo, Luciano Rolando and Maurizio Andreata",authors:[{id:"55553",title:"Prof.",name:"Federico",middleName:null,surname:"Millo",slug:"federico-millo",fullName:"Federico Millo"},{id:"119742",title:"Dr.",name:"Luciano",middleName:null,surname:"Rolando",slug:"luciano-rolando",fullName:"Luciano Rolando"},{id:"119743",title:"MSc.",name:"Maurizio",middleName:null,surname:"Andreata",slug:"maurizio-andreata",fullName:"Maurizio Andreata"}]},{id:"6738",doi:"10.5772/7106",title:"Hydrodynamic Simulation of Cyclone Separators",slug:"hydrodynamic-simulation-of-cyclone-separators",totalDownloads:19651,totalCrossrefCites:14,totalDimensionsCites:31,abstract:null,book:{id:"3194",slug:"computational-fluid-dynamics",title:"Computational Fluid Dynamics",fullTitle:"Computational Fluid Dynamics"},signatures:"Utikar, R., Darmawan, N., Tade, M., Li, Q, Evans, G., Glenny, M. and Pareek, V.",authors:[{id:"7765",title:"Prof.",name:"Vishnu",middleName:null,surname:"Pareek",slug:"vishnu-pareek",fullName:"Vishnu Pareek"},{id:"135094",title:"Dr.",name:"Ranjeet",middleName:null,surname:"Utikar",slug:"ranjeet-utikar",fullName:"Ranjeet Utikar"}]},{id:"20828",doi:"10.5772/22158",title:"Nanofluids for Heat Transfer – Potential and Engineering Strategies",slug:"nanofluids-for-heat-transfer-potential-and-engineering-strategies",totalDownloads:6650,totalCrossrefCites:6,totalDimensionsCites:31,abstract:null,book:{id:"532",slug:"two-phase-flow-phase-change-and-numerical-modeling",title:"Two Phase Flow, Phase Change and Numerical Modeling",fullTitle:"Two Phase Flow, Phase Change and Numerical Modeling"},signatures:"Elena V. Timofeeva",authors:[{id:"46547",title:"Dr.",name:"Elena",middleName:null,surname:"Timofeeva",slug:"elena-timofeeva",fullName:"Elena Timofeeva"}]}],mostDownloadedChaptersLast30Days:[{id:"58459",title:"Weighted Finite-Element Method for Elasticity Problems with Singularity",slug:"weighted-finite-element-method-for-elasticity-problems-with-singularity",totalDownloads:1175,totalCrossrefCites:6,totalDimensionsCites:9,abstract:"In this chapter, the two-dimensional elasticity problem with a singularity caused by the presence of a re-entrant corner on the domain boundary is considered. For this problem, the notion of the Rv-generalized solution is introduced. On the basis of the Rv-generalized solution, a scheme of the weighted finite-element method (FEM) is constructed. The proposed method provides a first-order convergence of the approximate solution to the exact one with respect to the mesh step in the \n\n\nW\n\n2\n,\nν\n\n1\n\n\nΩ\n\n\n-norm. The convergence rate does not depend on the size of the angle and kind of the boundary conditions imposed on its sides. Comparative analysis of the proposed method with a classical finite-element method and with an FEM with geometric mesh refinement to the singular point is carried out.",book:{id:"6281",slug:"finite-element-method-simulation-numerical-analysis-and-solution-techniques",title:"Finite Element Method",fullTitle:"Finite Element Method - Simulation, Numerical Analysis and Solution Techniques"},signatures:"Viktor Anatolievich Rukavishnikov and Elena Ivanovna\nRukavishnikova",authors:[{id:"211519",title:"Dr.",name:"Viktor",middleName:null,surname:"Rukavishnikov",slug:"viktor-rukavishnikov",fullName:"Viktor Rukavishnikov"},{id:"211520",title:"Dr.",name:"Elena",middleName:null,surname:"Rukavishnikov",slug:"elena-rukavishnikov",fullName:"Elena Rukavishnikov"}]},{id:"19446",title:"Numerical Modelling and Simulation of Radial-Axial Ring Rolling Process",slug:"numerical-modelling-and-simulation-of-radial-axial-ring-rolling-process",totalDownloads:6498,totalCrossrefCites:3,totalDimensionsCites:5,abstract:null,book:{id:"1363",slug:"numerical-analysis-theory-and-application",title:"Numerical Analysis",fullTitle:"Numerical Analysis - Theory and Application"},signatures:"Lianggang Guo and He Yang",authors:[{id:"58686",title:"Dr.",name:"Lianggang",middleName:null,surname:"Guo",slug:"lianggang-guo",fullName:"Lianggang Guo"}]},{id:"31925",title:"Computational Fluid Dynamics",slug:"computational-fluid-dynamics",totalDownloads:7309,totalCrossrefCites:1,totalDimensionsCites:4,abstract:null,book:{id:"1988",slug:"applied-computational-fluid-dynamics",title:"Applied Computational Fluid Dynamics",fullTitle:"Applied Computational Fluid Dynamics"},signatures:"Victor Udoewa and Vinod Kumar",authors:[{id:"74201",title:"Prof.",name:"Victor",middleName:null,surname:"Udoewa",slug:"victor-udoewa",fullName:"Victor Udoewa"}]},{id:"39242",title:"Numerical Simulation of Combustion in Porous Media",slug:"numerical-simulation-of-combustion-in-porous-media",totalDownloads:5943,totalCrossrefCites:0,totalDimensionsCites:1,abstract:null,book:{id:"2207",slug:"numerical-simulation-from-theory-to-industry",title:"Numerical Simulation",fullTitle:"Numerical Simulation - From Theory to Industry"},signatures:"Arash Mohammadi and Ali Jazayeri",authors:[{id:"13643",title:"Dr.",name:"Arash",middleName:null,surname:"Mohammadi",slug:"arash-mohammadi",fullName:"Arash Mohammadi"}]},{id:"28973",title:"Fluid-Structure Interaction",slug:"fluid-structure-interaction",totalDownloads:4852,totalCrossrefCites:0,totalDimensionsCites:0,abstract:null,book:{id:"1989",slug:"fluid-dynamics-computational-modeling-and-applications",title:"Fluid Dynamics, Computational Modeling and Applications",fullTitle:"Fluid Dynamics, Computational Modeling and Applications"},signatures:"Stoia-Djeska Marius and Safta Carmen-Anca",authors:[{id:"72867",title:"Dr.",name:"Marius",middleName:null,surname:"Stoia-Djeska",slug:"marius-stoia-djeska",fullName:"Marius Stoia-Djeska"},{id:"74940",title:"Dr.",name:"Carmen Anca",middleName:null,surname:"Safta",slug:"carmen-anca-safta",fullName:"Carmen Anca Safta"}]}],onlineFirstChaptersFilter:{topicId:"610",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:108,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:141,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:124,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:22,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:12,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"13",title:"Veterinary Medicine and Science",doi:"10.5772/intechopen.73681",issn:"2632-0517",scope:"Paralleling similar advances in the medical field, astounding advances occurred in Veterinary Medicine and Science in recent decades. These advances have helped foster better support for animal health, more humane animal production, and a better understanding of the physiology of endangered species to improve the assisted reproductive technologies or the pathogenesis of certain diseases, where animals can be used as models for human diseases (like cancer, degenerative diseases or fertility), and even as a guarantee of public health. Bridging Human, Animal, and Environmental health, the holistic and integrative “One Health” concept intimately associates the developments within those fields, projecting its advancements into practice. This book series aims to tackle various animal-related medicine and sciences fields, providing thematic volumes consisting of high-quality significant research directed to researchers and postgraduates. It aims to give us a glimpse into the new accomplishments in the Veterinary Medicine and Science field. By addressing hot topics in veterinary sciences, we aim to gather authoritative texts within each issue of this series, providing in-depth overviews and analysis for graduates, academics, and practitioners and foreseeing a deeper understanding of the subject. Forthcoming texts, written and edited by experienced researchers from both industry and academia, will also discuss scientific challenges faced today in Veterinary Medicine and Science. In brief, we hope that books in this series will provide accessible references for those interested or working in this field and encourage learning in a range of different topics.",coverUrl:"https://cdn.intechopen.com/series/covers/13.jpg",latestPublicationDate:"August 7th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:11,editor:{id:"38652",title:"Prof.",name:"Rita",middleName:null,surname:"Payan-Carreira",slug:"rita-payan-carreira",fullName:"Rita Payan-Carreira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRiFPQA0/Profile_Picture_1614601496313",biography:"Rita Payan Carreira earned her Veterinary Degree from the Faculty of Veterinary Medicine in Lisbon, Portugal, in 1985. She obtained her Ph.D. in Veterinary Sciences from the University of Trás-os-Montes e Alto Douro, Portugal. After almost 32 years of teaching at the University of Trás-os-Montes and Alto Douro, she recently moved to the University of Évora, Department of Veterinary Medicine, where she teaches in the field of Animal Reproduction and Clinics. Her primary research areas include the molecular markers of the endometrial cycle and the embryo–maternal interaction, including oxidative stress and the reproductive physiology and disorders of sexual development, besides the molecular determinants of male and female fertility. She often supervises students preparing their master's or doctoral theses. She is also a frequent referee for various journals.",institutionString:null,institution:{name:"University of Évora",institutionURL:null,country:{name:"Portugal"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:3,paginationItems:[{id:"19",title:"Animal Science",coverUrl:"https://cdn.intechopen.com/series_topics/covers/19.jpg",isOpenForSubmission:!0,editor:{id:"259298",title:"Dr.",name:"Edward",middleName:null,surname:"Narayan",slug:"edward-narayan",fullName:"Edward Narayan",profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",biography:"Dr. Edward Narayan graduated with Ph.D. degree in Biology from the University of the South Pacific and pioneered non-invasive reproductive and stress endocrinology tools for amphibians - the novel development and validation of non-invasive enzyme immunoassays for the evaluation of reproductive hormonal cycle and stress hormone responses to environmental stressors. \nDr. Narayan leads the Stress Lab (Comparative Physiology and Endocrinology) at the University of Queensland. A dynamic career research platform which is based on the thematic areas of comparative vertebrate physiology, stress endocrinology, reproductive endocrinology, animal health and welfare, and conservation biology. \nEdward has supervised 40 research students and published over 60 peer reviewed research.",institutionString:null,institution:{name:"University of Queensland",institutionURL:null,country:{name:"Australia"}}},editorTwo:null,editorThree:null},{id:"20",title:"Animal Nutrition",coverUrl:"https://cdn.intechopen.com/series_topics/covers/20.jpg",isOpenForSubmission:!0,editor:{id:"175967",title:"Dr.",name:"Manuel",middleName:null,surname:"Gonzalez Ronquillo",slug:"manuel-gonzalez-ronquillo",fullName:"Manuel Gonzalez Ronquillo",profilePictureURL:"https://mts.intechopen.com/storage/users/175967/images/system/175967.png",biography:"Dr. Manuel González Ronquillo obtained his doctorate degree from the University of Zaragoza, Spain, in 2001. He is a research professor at the Faculty of Veterinary Medicine and Animal Husbandry, Autonomous University of the State of Mexico. He is also a level-2 researcher. He received a Fulbright-Garcia Robles fellowship for a postdoctoral stay at the US Dairy Forage Research Center, Madison, Wisconsin, USA in 2008–2009. He received grants from Alianza del Pacifico for a stay at the University of Magallanes, Chile, in 2014, and from Consejo Nacional de Ciencia y Tecnología (CONACyT) to work in the Food and Agriculture Organization’s Animal Production and Health Division (AGA), Rome, Italy, in 2014–2015. He has collaborated with researchers from different countries and published ninety-eight journal articles. He teaches various degree courses in zootechnics, sheep production, and agricultural sciences and natural resources.\n\nDr. Ronquillo’s research focuses on the evaluation of sustainable animal diets (StAnD), using native resources of the region, decreasing carbon footprint, and applying meta-analysis and mathematical models for a better understanding of animal production.",institutionString:null,institution:{name:"Universidad Autónoma del Estado de México",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null},{id:"28",title:"Animal Reproductive Biology and Technology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/28.jpg",isOpenForSubmission:!0,editor:{id:"177225",title:"Prof.",name:"Rosa Maria Lino Neto",middleName:null,surname:"Pereira",slug:"rosa-maria-lino-neto-pereira",fullName:"Rosa Maria Lino Neto Pereira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bS9wkQAC/Profile_Picture_1624519982291",biography:"Rosa Maria Lino Neto Pereira (DVM, MsC, PhD and) is currently a researcher at the Genetic Resources and Biotechnology Unit of the National Institute of Agrarian and Veterinarian Research (INIAV, Portugal). She is the head of the Reproduction and Embryology Laboratories and was lecturer of Reproduction and Reproductive Biotechnologies at Veterinary Medicine Faculty. She has over 25 years of experience working in reproductive biology and biotechnology areas with a special emphasis on embryo and gamete cryopreservation, for research and animal genetic resources conservation, leading research projects with several peer-reviewed papers. Rosa Pereira is member of the ERFP-FAO Ex situ Working Group and of the Management Commission of the Portuguese Animal Germplasm Bank.",institutionString:"The National Institute for Agricultural and Veterinary Research. Portugal",institution:null},editorTwo:null,editorThree:null}]},overviewPageOFChapters:{paginationCount:20,paginationItems:[{id:"82991",title:"Diseases of the Canine Prostate Gland",doi:"10.5772/intechopen.105835",signatures:"Sabine Schäfer-Somi",slug:"diseases-of-the-canine-prostate-gland",totalDownloads:2,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Recent Advances in Canine Medicine",coverURL:"https://cdn.intechopen.com/books/images_new/11580.jpg",subseries:{id:"19",title:"Animal Science"}}},{id:"82956",title:"Potential Substitutes of Antibiotics for Swine and Poultry Production",doi:"10.5772/intechopen.106081",signatures:"Ho Trung Thong, Le Nu Anh Thu and Ho Viet Duc",slug:"potential-substitutes-of-antibiotics-for-swine-and-poultry-production",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Antibiotics and Probiotics in Animal Food - Impact and Regulation",coverURL:"https://cdn.intechopen.com/books/images_new/11578.jpg",subseries:{id:"20",title:"Animal Nutrition"}}},{id:"82905",title:"A Review of Application Strategies and Efficacy of Probiotics in Pet Food",doi:"10.5772/intechopen.105829",signatures:"Heather Acuff and Charles G. Aldrich",slug:"a-review-of-application-strategies-and-efficacy-of-probiotics-in-pet-food",totalDownloads:16,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Antibiotics and Probiotics in Animal Food - Impact and Regulation",coverURL:"https://cdn.intechopen.com/books/images_new/11578.jpg",subseries:{id:"20",title:"Animal Nutrition"}}},{id:"82773",title:"Canine Transmissible Venereal Tumor: An Infectious Neoplasia in Dogs",doi:"10.5772/intechopen.106150",signatures:"Chanokchon Setthawongsin, Somporn Techangamsuwan and Anudep Rungsipipat",slug:"canine-transmissible-venereal-tumor-an-infectious-neoplasia-in-dogs",totalDownloads:15,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Recent Advances in Canine Medicine",coverURL:"https://cdn.intechopen.com/books/images_new/11580.jpg",subseries:{id:"19",title:"Animal Science"}}}]},overviewPagePublishedBooks:{paginationCount:11,paginationItems:[{type:"book",id:"7233",title:"New Insights into Theriogenology",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7233.jpg",slug:"new-insights-into-theriogenology",publishedDate:"December 5th 2018",editedByType:"Edited by",bookSignature:"Rita Payan-Carreira",hash:"74f4147e3fb214dd050e5edd3aaf53bc",volumeInSeries:1,fullTitle:"New Insights into Theriogenology",editors:[{id:"38652",title:"Prof.",name:"Rita",middleName:null,surname:"Payan-Carreira",slug:"rita-payan-carreira",fullName:"Rita Payan-Carreira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRiFPQA0/Profile_Picture_1614601496313",biography:"Rita Payan Carreira earned her Veterinary Degree from the Faculty of Veterinary Medicine in Lisbon, Portugal, in 1985. She obtained her Ph.D. in Veterinary Sciences from the University of Trás-os-Montes e Alto Douro, Portugal. After almost 32 years of teaching at the University of Trás-os-Montes and Alto Douro, she recently moved to the University of Évora, Department of Veterinary Medicine, where she teaches in the field of Animal Reproduction and Clinics. Her primary research areas include the molecular markers of the endometrial cycle and the embryo–maternal interaction, including oxidative stress and the reproductive physiology and disorders of sexual development, besides the molecular determinants of male and female fertility. She often supervises students preparing their master's or doctoral theses. She is also a frequent referee for various journals.",institutionString:null,institution:{name:"University of Évora",institutionURL:null,country:{name:"Portugal"}}}]},{type:"book",id:"7144",title:"Veterinary Anatomy and Physiology",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7144.jpg",slug:"veterinary-anatomy-and-physiology",publishedDate:"March 13th 2019",editedByType:"Edited by",bookSignature:"Catrin Sian Rutland and Valentina Kubale",hash:"75cdacb570e0e6d15a5f6e69640d87c9",volumeInSeries:2,fullTitle:"Veterinary Anatomy and Physiology",editors:[{id:"202192",title:"Dr.",name:"Catrin",middleName:null,surname:"Rutland",slug:"catrin-rutland",fullName:"Catrin Rutland",profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",biography:"Catrin Rutland is an Associate Professor of Anatomy and Developmental Genetics at the University of Nottingham, UK. She obtained a BSc from the University of Derby, England, a master’s degree from Technische Universität München, Germany, and a Ph.D. from the University of Nottingham. She undertook a post-doctoral research fellowship in the School of Medicine before accepting tenure in Veterinary Medicine and Science. Dr. Rutland also obtained an MMedSci (Medical Education) and a Postgraduate Certificate in Higher Education (PGCHE). She is the author of more than sixty peer-reviewed journal articles, twelve books/book chapters, and more than 100 research abstracts in cardiovascular biology and oncology. She is a board member of the European Association of Veterinary Anatomists, Fellow of the Anatomical Society, and Senior Fellow of the Higher Education Academy. Dr. Rutland has also written popular science books for the public. https://orcid.org/0000-0002-2009-4898. www.nottingham.ac.uk/vet/people/catrin.rutland",institutionString:null,institution:{name:"University of Nottingham",institutionURL:null,country:{name:"United Kingdom"}}}]},{type:"book",id:"8524",title:"Lactation in Farm Animals",subtitle:"Biology, Physiological Basis, Nutritional Requirements, and Modelization",coverURL:"https://cdn.intechopen.com/books/images_new/8524.jpg",slug:"lactation-in-farm-animals-biology-physiological-basis-nutritional-requirements-and-modelization",publishedDate:"January 22nd 2020",editedByType:"Edited by",bookSignature:"Naceur M'Hamdi",hash:"2aa2a9a0ec13040bbf0455e34625504e",volumeInSeries:3,fullTitle:"Lactation in Farm Animals - Biology, Physiological Basis, Nutritional Requirements, and Modelization",editors:[{id:"73376",title:"Dr.",name:"Naceur",middleName:null,surname:"M'Hamdi",slug:"naceur-m'hamdi",fullName:"Naceur M'Hamdi",profilePictureURL:"https://mts.intechopen.com/storage/users/73376/images/system/73376.jpg",biography:"Naceur M’HAMDI is Associate Professor at the National Agronomic Institute of Tunisia, University of Carthage. He is also Member of the Laboratory of genetic, animal and feed resource and member of Animal science Department of INAT. He graduated from Higher School of Agriculture of Mateur, University of Carthage, in 2002 and completed his masters in 2006. Dr. M’HAMDI completed his PhD thesis in Genetic welfare indicators of dairy cattle at Higher Institute of Agronomy of Chott-Meriem, University of Sousse, in 2011. He worked as assistant Professor of Genetic, biostatistics and animal biotechnology at INAT since 2013.",institutionString:null,institution:null}]},{type:"book",id:"8460",title:"Reproductive Biology and Technology in Animals",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/8460.jpg",slug:"reproductive-biology-and-technology-in-animals",publishedDate:"April 15th 2020",editedByType:"Edited by",bookSignature:"Juan Carlos Gardón Poggi and Katy Satué Ambrojo",hash:"32ef5fe73998dd723d308225d756fa1e",volumeInSeries:4,fullTitle:"Reproductive Biology and Technology in Animals",editors:[{id:"251314",title:"Dr.",name:"Juan Carlos",middleName:null,surname:"Gardón Poggi",slug:"juan-carlos-gardon-poggi",fullName:"Juan Carlos Gardón Poggi",profilePictureURL:"https://mts.intechopen.com/storage/users/251314/images/system/251314.jpeg",biography:"Juan Carlos Gardón Poggi received University degree from the Faculty of Agrarian Science in Argentina, in 1983. Also he received Masters Degree and PhD from Córdoba University, Spain. He is currently a Professor at the Catholic University of Valencia San Vicente Mártir, at the Department of Medicine and Animal Surgery. He teaches diverse courses in the field of Animal Reproduction and he is the Director of the Veterinary Farm. He also participates in academic postgraduate activities at the Veterinary Faculty of Murcia University, Spain. His research areas include animal physiology, physiology and biotechnology of reproduction either in males or females, the study of gametes under in vitro conditions and the use of ultrasound as a complement to physiological studies and development of applied biotechnologies. Routinely, he supervises students preparing their doctoral, master thesis or final degree projects.",institutionString:null,institution:{name:"Valencia Catholic University Saint Vincent Martyr",institutionURL:null,country:{name:"Spain"}}}]}]},openForSubmissionBooks:{paginationCount:2,paginationItems:[{id:"11673",title:"Stem Cell Research",coverURL:"https://cdn.intechopen.com/books/images_new/11673.jpg",hash:"13092df328080c762dd9157be18ca38c",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"July 13th 2022",isOpenForSubmission:!0,editors:[{id:"203598",title:"Ph.D.",name:"Diana",surname:"Kitala",slug:"diana-kitala",fullName:"Diana Kitala"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"12215",title:"Cell Death and Disease",coverURL:"https://cdn.intechopen.com/books/images_new/12215.jpg",hash:"dfd456a29478fccf4ebd3294137eb1e3",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"July 29th 2022",isOpenForSubmission:!0,editors:[{id:"59529",title:"Dr.",name:"Ke",surname:"Xu",slug:"ke-xu",fullName:"Ke Xu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},onlineFirstChapters:{paginationCount:21,paginationItems:[{id:"83000",title:"Purine and Pyrimidine Pathways as Antimalarial Targets",doi:"10.5772/intechopen.106468",signatures:"Yacoba V.T. Minnow and Vern L. Schramm",slug:"purine-and-pyrimidine-pathways-as-antimalarial-targets",totalDownloads:1,totalCrossrefCites:0,totalDimensionsCites:null,authors:null,book:{title:"Malaria - Recent Advances, and New Perspectives",coverURL:"https://cdn.intechopen.com/books/images_new/11576.jpg",subseries:{id:"5",title:"Parasitic Infectious Diseases"}}},{id:"83065",title:"Interventions and Practical Approaches to Reduce the Burden of Malaria on School-Aged Children",doi:"10.5772/intechopen.106469",signatures:"Andrew Macnab",slug:"interventions-and-practical-approaches-to-reduce-the-burden-of-malaria-on-school-aged-children",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:[{name:"Andrew",surname:"Macnab"}],book:{title:"Malaria - Recent Advances, and New Perspectives",coverURL:"https://cdn.intechopen.com/books/images_new/11576.jpg",subseries:{id:"5",title:"Parasitic Infectious Diseases"}}},{id:"82804",title:"Psychiatric Problems in HIV Care",doi:"10.5772/intechopen.106077",signatures:"Seggane Musisi and Noeline Nakasujja",slug:"psychiatric-problems-in-hiv-care",totalDownloads:2,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Future Opportunities and Tools for Emerging Challenges for HIV/AIDS Control",coverURL:"https://cdn.intechopen.com/books/images_new/11575.jpg",subseries:{id:"6",title:"Viral Infectious Diseases"}}},{id:"82827",title:"Epidemiology and Control of Schistosomiasis",doi:"10.5772/intechopen.105170",signatures:"Célestin Kyambikwa Bisangamo",slug:"epidemiology-and-control-of-schistosomiasis",totalDownloads:6,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"New Horizons for Schistosomiasis Research",coverURL:"https://cdn.intechopen.com/books/images_new/10829.jpg",subseries:{id:"5",title:"Parasitic Infectious Diseases"}}},{id:"82817",title:"Perspective Chapter: Microfluidic Technologies for On-Site Detection and Quantification of Infectious Diseases - The Experience with SARS-CoV-2/COVID-19",doi:"10.5772/intechopen.105950",signatures:"Andres Escobar and Chang-qing Xu",slug:"perspective-chapter-microfluidic-technologies-for-on-site-detection-and-quantification-of-infectious",totalDownloads:3,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"SARS-CoV-2 Variants - Two Years After",coverURL:"https://cdn.intechopen.com/books/images_new/11573.jpg",subseries:{id:"6",title:"Viral Infectious Diseases"}}},{id:"82667",title:"Perspective Chapter: Analysis of SARS-CoV-2 Indirect Spreading Routes and Possible Countermeasures",doi:"10.5772/intechopen.105914",signatures:"Cesare Saccani, Marco Pellegrini and Alessandro Guzzini",slug:"perspective-chapter-analysis-of-sars-cov-2-indirect-spreading-routes-and-possible-countermeasures",totalDownloads:10,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"SARS-CoV-2 Variants - Two Years After",coverURL:"https://cdn.intechopen.com/books/images_new/11573.jpg",subseries:{id:"6",title:"Viral Infectious Diseases"}}},{id:"82559",title:"Perspective Chapter: Bioinformatics Study of the Evolution of SARS-CoV-2 Spike Protein",doi:"10.5772/intechopen.105915",signatures:"Črtomir Podlipnik, Radostina Alexandrova, Sebastian Pleško, Urban Bren and Marko Jukič",slug:"perspective-chapter-bioinformatics-study-of-the-evolution-of-sars-cov-2-spike-protein",totalDownloads:16,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"SARS-CoV-2 Variants - Two Years After",coverURL:"https://cdn.intechopen.com/books/images_new/11573.jpg",subseries:{id:"6",title:"Viral Infectious Diseases"}}},{id:"82521",title:"Challenges in Platelet Functions in HIV/AIDS Management",doi:"10.5772/intechopen.105731",signatures:"Gordon Ogweno",slug:"challenges-in-platelet-functions-in-hiv-aids-management",totalDownloads:16,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Future Opportunities and Tools for Emerging Challenges for HIV/AIDS Control",coverURL:"https://cdn.intechopen.com/books/images_new/11575.jpg",subseries:{id:"6",title:"Viral Infectious Diseases"}}},{id:"82701",title:"Pathology of Streptococcal Infections",doi:"10.5772/intechopen.105814",signatures:"Yutaka Tsutsumi",slug:"pathology-of-streptococcal-infections",totalDownloads:8,totalCrossrefCites:0,totalDimensionsCites:0,authors:[{name:"Yutaka",surname:"Tsutsumi"}],book:{title:"Streptococcal Infections",coverURL:"https://cdn.intechopen.com/books/images_new/10828.jpg",subseries:{id:"3",title:"Bacterial Infectious Diseases"}}},{id:"82634",title:"Bacterial Sexually Transmitted Disease",doi:"10.5772/intechopen.105747",signatures:"Lebeza Alemu Tenaw",slug:"bacterial-sexually-transmitted-disease",totalDownloads:12,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Bacterial Sexually Transmitted Infections - New Findings, Diagnosis, Treatment, and Prevention",coverURL:"https://cdn.intechopen.com/books/images_new/11569.jpg",subseries:{id:"3",title:"Bacterial Infectious Diseases"}}}]},subseriesFiltersForOFChapters:[{caption:"Fungal Infectious Diseases",value:4,count:1,group:"subseries"},{caption:"Bacterial Infectious Diseases",value:3,count:5,group:"subseries"},{caption:"Parasitic Infectious Diseases",value:5,count:5,group:"subseries"},{caption:"Viral Infectious Diseases",value:6,count:10,group:"subseries"}],publishedBooks:{paginationCount:33,paginationItems:[{type:"book",id:"10840",title:"Benzimidazole",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/10840.jpg",slug:"benzimidazole",publishedDate:"July 13th 2022",editedByType:"Edited by",bookSignature:"Pravin Kendrekar and Vinayak Adimule",hash:"e28c770013e7a8dd0fc37aea6aa9def8",volumeInSeries:34,fullTitle:"Benzimidazole",editors:[{id:"310674",title:"Dr.",name:"Pravin",middleName:null,surname:"Kendrekar",slug:"pravin-kendrekar",fullName:"Pravin Kendrekar",profilePictureURL:"https://mts.intechopen.com/storage/users/310674/images/system/310674.jpg",institutionString:"Visiting Scientist at Lipid Nanostructures Laboratory, Centre for Smart Materials, School of Natural Sciences, University of Central Lancashire",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"10798",title:"Starch",subtitle:"Evolution and Recent Advances",coverURL:"https://cdn.intechopen.com/books/images_new/10798.jpg",slug:"starch-evolution-and-recent-advances",publishedDate:"June 28th 2022",editedByType:"Edited by",bookSignature:"Martins Ochubiojo Emeje",hash:"f197f6062c1574a9a90e50a369271bcf",volumeInSeries:33,fullTitle:"Starch - Evolution and Recent Advances",editors:[{id:"94311",title:"Prof.",name:"Martins",middleName:"Ochubiojo",surname:"Ochubiojo Emeje",slug:"martins-ochubiojo-emeje",fullName:"Martins Ochubiojo Emeje",profilePictureURL:"https://mts.intechopen.com/storage/users/94311/images/system/94311.jpeg",institutionString:"National Institute for Pharmaceutical Research and Development",institution:{name:"National Institute for Pharmaceutical Research and Development",institutionURL:null,country:{name:"Nigeria"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"11332",title:"Essential Oils",subtitle:"Advances in Extractions and Biological Applications",coverURL:"https://cdn.intechopen.com/books/images_new/11332.jpg",slug:"essential-oils-advances-in-extractions-and-biological-applications",publishedDate:"June 23rd 2022",editedByType:"Edited by",bookSignature:"Mozaniel Santana de Oliveira and Eloisa Helena de Aguiar Andrade",hash:"742e6cae3a35686f975edc8d7f9afa94",volumeInSeries:32,fullTitle:"Essential Oils - Advances in Extractions and Biological Applications",editors:[{id:"195290",title:"Ph.D.",name:"Mozaniel",middleName:null,surname:"Santana De Oliveira",slug:"mozaniel-santana-de-oliveira",fullName:"Mozaniel Santana De Oliveira",profilePictureURL:"https://mts.intechopen.com/storage/users/195290/images/system/195290.png",institutionString:"Museu Paraense Emílio Goeldi",institution:{name:"Museu Paraense Emílio Goeldi",institutionURL:null,country:{name:"Brazil"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"10839",title:"Protein Detection",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/10839.jpg",slug:"protein-detection",publishedDate:"June 23rd 2022",editedByType:"Edited by",bookSignature:"Yusuf Tutar and Lütfi Tutar",hash:"2f1c0e4e0207fc45c936e7d22a5369c4",volumeInSeries:31,fullTitle:"Protein Detection",editors:[{id:"158492",title:"Prof.",name:"Yusuf",middleName:null,surname:"Tutar",slug:"yusuf-tutar",fullName:"Yusuf Tutar",profilePictureURL:"https://mts.intechopen.com/storage/users/158492/images/system/158492.jpeg",institutionString:"University of Health Sciences",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"10797",title:"Cell Culture",subtitle:"Advanced Technology and Applications in Medical and Life Sciences",coverURL:"https://cdn.intechopen.com/books/images_new/10797.jpg",slug:"cell-culture-advanced-technology-and-applications-in-medical-and-life-sciences",publishedDate:"June 15th 2022",editedByType:"Edited by",bookSignature:"Xianquan Zhan",hash:"2c628f4757f9639a4450728d839a7842",volumeInSeries:30,fullTitle:"Cell Culture - Advanced Technology and Applications in Medical and Life Sciences",editors:[{id:"223233",title:"Prof.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",profilePictureURL:"https://mts.intechopen.com/storage/users/223233/images/system/223233.png",institutionString:"Shandong First Medical University",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"10841",title:"Hydrolases",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/10841.jpg",slug:"hydrolases",publishedDate:"June 15th 2022",editedByType:"Edited by",bookSignature:"Sajjad Haider, Adnan Haider and Angel Catalá",hash:"4e868cde273d65a7ff54b1817d640629",volumeInSeries:29,fullTitle:"Hydrolases",editors:[{id:"110708",title:"Dr.",name:"Sajjad",middleName:null,surname:"Haider",slug:"sajjad-haider",fullName:"Sajjad Haider",profilePictureURL:"https://mts.intechopen.com/storage/users/110708/images/system/110708.png",institutionString:"King Saud University",institution:{name:"King Saud University",institutionURL:null,country:{name:"Saudi Arabia"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"10803",title:"Reactive Oxygen Species",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/10803.jpg",slug:"reactive-oxygen-species",publishedDate:"April 28th 2022",editedByType:"Edited by",bookSignature:"Rizwan Ahmad",hash:"176adcf090fdd1f93cb8ce3146e79ca1",volumeInSeries:28,fullTitle:"Reactive Oxygen Species",editors:[{id:"40482",title:null,name:"Rizwan",middleName:null,surname:"Ahmad",slug:"rizwan-ahmad",fullName:"Rizwan Ahmad",profilePictureURL:"https://mts.intechopen.com/storage/users/40482/images/system/40482.jpeg",institutionString:"Imam Abdulrahman Bin Faisal University",institution:{name:"Imam Abdulrahman Bin Faisal University",institutionURL:null,country:{name:"Saudi Arabia"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9008",title:"Vitamin K",subtitle:"Recent Topics on the Biology and Chemistry",coverURL:"https://cdn.intechopen.com/books/images_new/9008.jpg",slug:"vitamin-k-recent-topics-on-the-biology-and-chemistry",publishedDate:"March 23rd 2022",editedByType:"Edited by",bookSignature:"Hiroyuki Kagechika and Hitoshi Shirakawa",hash:"8b43add5389ba85743e0a9491e4b9943",volumeInSeries:27,fullTitle:"Vitamin K - Recent Topics on the Biology and Chemistry",editors:[{id:"180528",title:"Dr.",name:"Hiroyuki",middleName:null,surname:"Kagechika",slug:"hiroyuki-kagechika",fullName:"Hiroyuki Kagechika",profilePictureURL:"https://mts.intechopen.com/storage/users/180528/images/system/180528.jpg",institutionString:"Tokyo Medical and Dental University",institution:{name:"Tokyo Medical and Dental University",institutionURL:null,country:{name:"Japan"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"10799",title:"Phenolic Compounds",subtitle:"Chemistry, Synthesis, Diversity, Non-Conventional Industrial, Pharmaceutical and Therapeutic Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10799.jpg",slug:"phenolic-compounds-chemistry-synthesis-diversity-non-conventional-industrial-pharmaceutical-and-therapeutic-applications",publishedDate:"February 23rd 2022",editedByType:"Edited by",bookSignature:"Farid A. Badria",hash:"339199f254d2987ef3167eef74fb8a38",volumeInSeries:26,fullTitle:"Phenolic Compounds - Chemistry, Synthesis, Diversity, Non-Conventional Industrial, Pharmaceutical and Therapeutic Applications",editors:[{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria",profilePictureURL:"https://mts.intechopen.com/storage/users/41865/images/system/41865.jpg",institutionString:"Mansoura University",institution:{name:"Mansoura University",institutionURL:null,country:{name:"Egypt"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9659",title:"Fibroblasts",subtitle:"Advances in Inflammation, Autoimmunity and Cancer",coverURL:"https://cdn.intechopen.com/books/images_new/9659.jpg",slug:"fibroblasts-advances-in-inflammation-autoimmunity-and-cancer",publishedDate:"December 22nd 2021",editedByType:"Edited by",bookSignature:"Mojca Frank Bertoncelj and Katja Lakota",hash:"926fa6446f6befbd363fc74971a56de2",volumeInSeries:25,fullTitle:"Fibroblasts - Advances in Inflammation, Autoimmunity and Cancer",editors:[{id:"328755",title:"Ph.D.",name:"Mojca",middleName:null,surname:"Frank Bertoncelj",slug:"mojca-frank-bertoncelj",fullName:"Mojca Frank Bertoncelj",profilePictureURL:"https://mts.intechopen.com/storage/users/328755/images/system/328755.jpg",institutionString:"BioMed X Institute",institution:{name:"University Hospital of Zurich",institutionURL:null,country:{name:"Switzerland"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8977",title:"Protein Kinases",subtitle:"Promising Targets for Anticancer Drug Research",coverURL:"https://cdn.intechopen.com/books/images_new/8977.jpg",slug:"protein-kinases-promising-targets-for-anticancer-drug-research",publishedDate:"December 8th 2021",editedByType:"Edited by",bookSignature:"Rajesh Kumar Singh",hash:"6d200cc031706a565b554fdb1c478901",volumeInSeries:24,fullTitle:"Protein Kinases - Promising Targets for Anticancer Drug Research",editors:[{id:"329385",title:"Dr.",name:"Rajesh K.",middleName:"Kumar",surname:"Singh",slug:"rajesh-k.-singh",fullName:"Rajesh K. Singh",profilePictureURL:"https://mts.intechopen.com/storage/users/329385/images/system/329385.png",institutionString:"Punjab Technical University",institution:{name:"Punjab Technical University",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8018",title:"Extracellular Matrix",subtitle:"Developments and Therapeutics",coverURL:"https://cdn.intechopen.com/books/images_new/8018.jpg",slug:"extracellular-matrix-developments-and-therapeutics",publishedDate:"October 27th 2021",editedByType:"Edited by",bookSignature:"Rama Sashank Madhurapantula, Joseph Orgel P.R.O. and Zvi Loewy",hash:"c85e82851e80b40282ff9be99ddf2046",volumeInSeries:23,fullTitle:"Extracellular Matrix - Developments and Therapeutics",editors:[{id:"212416",title:"Dr.",name:"Rama Sashank",middleName:null,surname:"Madhurapantula",slug:"rama-sashank-madhurapantula",fullName:"Rama Sashank Madhurapantula",profilePictureURL:"https://mts.intechopen.com/storage/users/212416/images/system/212416.jpg",institutionString:"Illinois Institute of Technology",institution:{name:"Illinois Institute of Technology",institutionURL:null,country:{name:"United States of America"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Proteomics",value:18,count:4},{group:"subseries",caption:"Metabolism",value:17,count:6},{group:"subseries",caption:"Cell and Molecular Biology",value:14,count:9},{group:"subseries",caption:"Chemical Biology",value:15,count:14}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:9},{group:"publicationYear",caption:"2021",value:2021,count:7},{group:"publicationYear",caption:"2020",value:2020,count:12},{group:"publicationYear",caption:"2019",value:2019,count:3},{group:"publicationYear",caption:"2018",value:2018,count:2}],authors:{paginationCount:148,paginationItems:[{id:"165328",title:"Dr.",name:"Vahid",middleName:null,surname:"Asadpour",slug:"vahid-asadpour",fullName:"Vahid Asadpour",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/165328/images/system/165328.jpg",biography:"Vahid Asadpour, MS, Ph.D., is currently with the Department of Research and Evaluation, Kaiser Permanente Southern California. He has both an MS and Ph.D. in Biomedical Engineering. He was previously a research scientist at the University of California Los Angeles (UCLA) and visiting professor and researcher at the University of North Dakota. He is currently working in artificial intelligence and its applications in medical signal processing. In addition, he is using digital signal processing in medical imaging and speech processing. Dr. Asadpour has developed brain-computer interfacing algorithms and has published books, book chapters, and several journal and conference papers in this field and other areas of intelligent signal processing. He has also designed medical devices, including a laser Doppler monitoring system.",institutionString:"Kaiser Permanente Southern California",institution:null},{id:"169608",title:"Prof.",name:"Marian",middleName:null,surname:"Găiceanu",slug:"marian-gaiceanu",fullName:"Marian Găiceanu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/169608/images/system/169608.png",biography:"Prof. Dr. Marian Gaiceanu graduated from the Naval and Electrical Engineering Faculty, Dunarea de Jos University of Galati, Romania, in 1997. He received a Ph.D. (Magna Cum Laude) in Electrical Engineering in 2002. Since 2017, Dr. Gaiceanu has been a Ph.D. supervisor for students in Electrical Engineering. He has been employed at Dunarea de Jos University of Galati since 1996, where he is currently a professor. Dr. Gaiceanu is a member of the National Council for Attesting Titles, Diplomas and Certificates, an expert of the Executive Agency for Higher Education, Research Funding, and a member of the Senate of the Dunarea de Jos University of Galati. He has been the head of the Integrated Energy Conversion Systems and Advanced Control of Complex Processes Research Center, Romania, since 2016. He has conducted several projects in power converter systems for electrical drives, power quality, PEM and SOFC fuel cell power converters for utilities, electric vehicles, and marine applications with the Department of Regulation and Control, SIEI S.pA. (2002–2004) and the Polytechnic University of Turin, Italy (2002–2004, 2006–2007). He is a member of the Institute of Electrical and Electronics Engineers (IEEE) and cofounder-member of the IEEE Power Electronics Romanian Chapter. He is a guest editor at Energies and an academic book editor for IntechOpen. He is also a member of the editorial boards of the Journal of Electrical Engineering, Electronics, Control and Computer Science and Sustainability. Dr. Gaiceanu has been General Chairman of the IEEE International Symposium on Electrical and Electronics Engineering in the last six editions.",institutionString:'"Dunarea de Jos" University of Galati',institution:{name:'"Dunarea de Jos" University of Galati',country:{name:"Romania"}}},{id:"4519",title:"Prof.",name:"Jaydip",middleName:null,surname:"Sen",slug:"jaydip-sen",fullName:"Jaydip Sen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/4519/images/system/4519.jpeg",biography:"Jaydip Sen is associated with Praxis Business School, Kolkata, India, as a professor in the Department of Data Science. His research areas include security and privacy issues in computing and communication, intrusion detection systems, machine learning, deep learning, and artificial intelligence in the financial domain. He has more than 200 publications in reputed international journals, refereed conference proceedings, and 20 book chapters in books published by internationally renowned publishing houses, such as Springer, CRC press, IGI Global, etc. Currently, he is serving on the editorial board of the prestigious journal Frontiers in Communications and Networks and in the technical program committees of a number of high-ranked international conferences organized by the IEEE, USA, and the ACM, USA. He has been listed among the top 2% of scientists in the world for the last three consecutive years, 2019 to 2021 as per studies conducted by the Stanford University, USA.",institutionString:"Praxis Business School",institution:null},{id:"320071",title:"Dr.",name:"Sidra",middleName:null,surname:"Mehtab",slug:"sidra-mehtab",fullName:"Sidra Mehtab",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00002v6KHoQAM/Profile_Picture_1584512086360",biography:"Sidra Mehtab has completed her BS with honors in Physics from Calcutta University, India in 2018. She has done MS in Data Science and Analytics from Maulana Abul Kalam Azad University of Technology (MAKAUT), Kolkata, India in 2020. Her research areas include Econometrics, Time Series Analysis, Machine Learning, Deep Learning, Artificial Intelligence, and Computer and Network Security with a particular focus on Cyber Security Analytics. Ms. Mehtab has published seven papers in international conferences and one of her papers has been accepted for publication in a reputable international journal. She has won the best paper awards in two prestigious international conferences – BAICONF 2019, and ICADCML 2021, organized in the Indian Institute of Management, Bangalore, India in December 2019, and SOA University, Bhubaneswar, India in January 2021. Besides, Ms. Mehtab has also published two book chapters in two books. Seven of her book chapters will be published in a volume shortly in 2021 by Cambridge Scholars’ Press, UK. Currently, she is working as the joint editor of two edited volumes on Time Series Analysis and Forecasting to be published in the first half of 2021 by an international house. Currently, she is working as a Data Scientist with an MNC in Delhi, India.",institutionString:"NSHM College of Management and Technology",institution:{name:"Association for Computing Machinery",country:{name:"United States of America"}}},{id:"226240",title:"Dr.",name:"Andri Irfan",middleName:null,surname:"Rifai",slug:"andri-irfan-rifai",fullName:"Andri Irfan Rifai",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/226240/images/7412_n.jpg",biography:"Andri IRFAN is a Senior Lecturer of Civil Engineering and Planning. He completed the PhD at the Universitas Indonesia & Universidade do Minho with Sandwich Program Scholarship from the Directorate General of Higher Education and LPDP scholarship. He has been teaching for more than 19 years and much active to applied his knowledge in the project construction in Indonesia. His research interest ranges from pavement management system to advanced data mining techniques for transportation engineering. He has published more than 50 papers in journals and 2 books.",institutionString:null,institution:{name:"Universitas Internasional Batam",country:{name:"Indonesia"}}},{id:"314576",title:"Dr.",name:"Ibai",middleName:null,surname:"Laña",slug:"ibai-lana",fullName:"Ibai Laña",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/314576/images/system/314576.jpg",biography:"Dr. Ibai Laña works at TECNALIA as a data analyst. He received his Ph.D. in Artificial Intelligence from the University of the Basque Country (UPV/EHU), Spain, in 2018. He is currently a senior researcher at TECNALIA. His research interests fall within the intersection of intelligent transportation systems, machine learning, traffic data analysis, and data science. He has dealt with urban traffic forecasting problems, applying machine learning models and evolutionary algorithms. He has experience in origin-destination matrix estimation or point of interest and trajectory detection. Working with large volumes of data has given him a good command of big data processing tools and NoSQL databases. He has also been a visiting scholar at the Knowledge Engineering and Discovery Research Institute, Auckland University of Technology.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"314575",title:"Dr.",name:"Jesus",middleName:null,surname:"L. Lobo",slug:"jesus-l.-lobo",fullName:"Jesus L. Lobo",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/314575/images/system/314575.png",biography:"Dr. Jesús López is currently based in Bilbao (Spain) working at TECNALIA as Artificial Intelligence Research Scientist. In most cases, a project idea or a new research line needs to be investigated to see if it is good enough to take into production or to focus on it. That is exactly what he does, diving into Machine Learning algorithms and technologies to help TECNALIA to decide whether something is great in theory or will actually impact on the product or processes of its projects. So, he is expert at framing experiments, developing hypotheses, and proving whether they’re true or not, in order to investigate fundamental problems with a longer time horizon. He is also able to design and develop PoCs and system prototypes in simulation. He has participated in several national and internacional R&D projects.\n\nAs another relevant part of his everyday research work, he usually publishes his findings in reputed scientific refereed journals and international conferences, occasionally acting as reviewer and Programme Commitee member. Concretely, since 2018 he has published 9 JCR (8 Q1) journal papers, 9 conference papers (e.g. ECML PKDD 2021), and he has co-edited a book. He is also active in popular science writing data science stories for reputed blogs (KDNuggets, TowardsDataScience, Naukas). Besides, he has recently embarked on mentoring programmes as mentor, and has also worked as data science trainer.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"103779",title:"Prof.",name:"Yalcin",middleName:null,surname:"Isler",slug:"yalcin-isler",fullName:"Yalcin Isler",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRyQ8QAK/Profile_Picture_1628834958734",biography:"Yalcin Isler (1971 - Burdur / Turkey) received the B.Sc. degree in the Department of Electrical and Electronics Engineering from Anadolu University, Eskisehir, Turkey, in 1993, the M.Sc. degree from the Department of Electronics and Communication Engineering, Suleyman Demirel University, Isparta, Turkey, in 1996, the Ph.D. degree from the Department of Electrical and Electronics Engineering, Dokuz Eylul University, Izmir, Turkey, in 2009, and the Competence of Associate Professorship from the Turkish Interuniversity Council in 2019.\n\nHe was Lecturer at Burdur Vocational School in Suleyman Demirel University (1993-2000, Burdur / Turkey), Software Engineer (2000-2002, Izmir / Turkey), Research Assistant in Bulent Ecevit University (2002-2003, Zonguldak / Turkey), Research Assistant in Dokuz Eylul University (2003-2010, Izmir / Turkey), Assistant Professor at the Department of Electrical and Electronics Engineering in Bulent Ecevit University (2010-2012, Zonguldak / Turkey), Assistant Professor at the Department of Biomedical Engineering in Izmir Katip Celebi University (2012-2019, Izmir / Turkey). He is an Associate Professor at the Department of Biomedical Engineering at Izmir Katip Celebi University, Izmir / Turkey, since 2019. In addition to academics, he has also founded Islerya Medical and Information Technologies Company, Izmir / Turkey, since 2017.\n\nHis main research interests cover biomedical signal processing, pattern recognition, medical device design, programming, and embedded systems. He has many scientific papers and participated in several projects in these study fields. He was an IEEE Student Member (2009-2011) and IEEE Member (2011-2014) and has been IEEE Senior Member since 2014.",institutionString:null,institution:{name:"Izmir Kâtip Çelebi University",country:{name:"Turkey"}}},{id:"339677",title:"Dr.",name:"Mrinmoy",middleName:null,surname:"Roy",slug:"mrinmoy-roy",fullName:"Mrinmoy Roy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/339677/images/16768_n.jpg",biography:"An accomplished Sales & Marketing professional with 12 years of cross-functional experience in well-known organisations such as CIPLA, LUPIN, GLENMARK, ASTRAZENECA across different segment of Sales & Marketing, International Business, Institutional Business, Product Management, Strategic Marketing of HIV, Oncology, Derma, Respiratory, Anti-Diabetic, Nutraceutical & Stomatological Product Portfolio and Generic as well as Chronic Critical Care Portfolio. A First Class MBA in International Business & Strategic Marketing, B.Pharm, D.Pharm, Google Certified Digital Marketing Professional. Qualified PhD Candidate in Operations and Management with special focus on Artificial Intelligence and Machine Learning adoption, analysis and use in Healthcare, Hospital & Pharma Domain. Seasoned with diverse therapy area of Pharmaceutical Sales & Marketing ranging from generating revenue through generating prescriptions, launching new products, and making them big brands with continuous strategy execution at the Physician and Patients level. Moved from Sales to Marketing and Business Development for 3.5 years in South East Asian Market operating from Manila, Philippines. Came back to India and handled and developed Brands such as Gluconorm, Lupisulin, Supracal, Absolut Woman, Hemozink, Fabiflu (For COVID 19), and many more. In my previous assignment I used to develop and execute strategies on Sales & Marketing, Commercialization & Business Development for Institution and Corporate Hospital Business portfolio of Oncology Therapy Area for AstraZeneca Pharma India Ltd. Being a Research Scholar and Student of ‘Operations Research & Management: Artificial Intelligence’ I published several pioneer research papers and book chapters on the same in Internationally reputed journals and Books indexed in Scopus, Springer and Ei Compendex, Google Scholar etc. Currently, I am launching PGDM Pharmaceutical Management Program in IIHMR Bangalore and spearheading the course curriculum and structure of the same. I am interested in Collaboration for Healthcare Innovation, Pharma AI Innovation, Future trend in Marketing and Management with incubation on Healthcare, Healthcare IT startups, AI-ML Modelling and Healthcare Algorithm based training module development. I am also an affiliated member of the Institute of Management Consultant of India, looking forward to Healthcare, Healthcare IT and Innovation, Pharma and Hospital Management Consulting works.",institutionString:null,institution:{name:"Lovely Professional University",country:{name:"India"}}},{id:"310576",title:"Prof.",name:"Erick Giovani",middleName:null,surname:"Sperandio Nascimento",slug:"erick-giovani-sperandio-nascimento",fullName:"Erick Giovani Sperandio Nascimento",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0033Y00002pDKxDQAW/ProfilePicture%202022-06-20%2019%3A57%3A24.788",biography:"Prof. Erick Sperandio is the Lead Researcher and professor of Artificial Intelligence (AI) at SENAI CIMATEC, Bahia, Brazil, also working with Computational Modeling (CM) and HPC. He holds a PhD in Environmental Engineering in the area of Atmospheric Computational Modeling, a Master in Informatics in the field of Computational Intelligence and Graduated in Computer Science from UFES. He currently coordinates, leads and participates in R&D projects in the areas of AI, computational modeling and supercomputing applied to different areas such as Oil and Gas, Health, Advanced Manufacturing, Renewable Energies and Atmospheric Sciences, advising undergraduate, master's and doctoral students. He is the Lead Researcher at SENAI CIMATEC's Reference Center on Artificial Intelligence. In addition, he is a Certified Instructor and University Ambassador of the NVIDIA Deep Learning Institute (DLI) in the areas of Deep Learning, Computer Vision, Natural Language Processing and Recommender Systems, and Principal Investigator of the NVIDIA/CIMATEC AI Joint Lab, the first in Latin America within the NVIDIA AI Technology Center (NVAITC) worldwide program. He also works as a researcher at the Supercomputing Center for Industrial Innovation (CS2i) and at the SENAI Institute of Innovation for Automation (ISI Automação), both from SENAI CIMATEC. He is a member and vice-coordinator of the Basic Board of Scientific-Technological Advice and Evaluation, in the area of Innovation, of the Foundation for Research Support of the State of Bahia (FAPESB). He serves as Technology Transfer Coordinator and one of the Principal Investigators at the National Applied Research Center in Artificial Intelligence (CPA-IA) of SENAI CIMATEC, focusing on Industry, being one of the six CPA-IA in Brazil approved by MCTI / FAPESP / CGI.br. He also participates as one of the representatives of Brazil in the BRICS Innovation Collaboration Working Group on HPC, ICT and AI. He is the coordinator of the Work Group of the Axis 5 - Workforce and Training - of the Brazilian Strategy for Artificial Intelligence (EBIA), and member of the MCTI/EMBRAPII AI Innovation Network Training Committee. He is the coordinator, by SENAI CIMATEC, of the Artificial Intelligence Reference Network of the State of Bahia (REDE BAH.IA). He leads the working group of experts representing Brazil in the Global Partnership on Artificial Intelligence (GPAI), on the theme \"AI and the Pandemic Response\".",institutionString:"Manufacturing and Technology Integrated Campus – SENAI CIMATEC",institution:null},{id:"1063",title:"Prof.",name:"Constantin",middleName:null,surname:"Volosencu",slug:"constantin-volosencu",fullName:"Constantin Volosencu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/1063/images/system/1063.png",biography:"Prof. Dr. Constantin Voloşencu graduated as an engineer from\nPolitehnica University of Timișoara, Romania, where he also\nobtained a doctorate degree. He is currently a full professor in\nthe Department of Automation and Applied Informatics at the\nsame university. Dr. Voloşencu is the author of ten books, seven\nbook chapters, and more than 160 papers published in journals\nand conference proceedings. He has also edited twelve books and\nhas twenty-seven patents to his name. He is a manager of research grants, editor in\nchief and member of international journal editorial boards, a former plenary speaker, a member of scientific committees, and chair at international conferences. His\nresearch is in the fields of control systems, control of electric drives, fuzzy control\nsystems, neural network applications, fault detection and diagnosis, sensor network\napplications, monitoring of distributed parameter systems, and power ultrasound\napplications. He has developed automation equipment for machine tools, spooling\nmachines, high-power ultrasound processes, and more.",institutionString:'"Politechnica" University Timişoara',institution:null},{id:"221364",title:"Dr.",name:"Eneko",middleName:null,surname:"Osaba",slug:"eneko-osaba",fullName:"Eneko Osaba",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/221364/images/system/221364.jpg",biography:"Dr. Eneko Osaba works at TECNALIA as a senior researcher. He obtained his Ph.D. in Artificial Intelligence in 2015. He has participated in more than twenty-five local and European research projects, and in the publication of more than 130 papers. He has performed several stays at universities in the United Kingdom, Italy, and Malta. Dr. Osaba has served as a program committee member in more than forty international conferences and participated in organizing activities in more than ten international conferences. He is a member of the editorial board of the International Journal of Artificial Intelligence, Data in Brief, and Journal of Advanced Transportation. He is also a guest editor for the Journal of Computational Science, Neurocomputing, Swarm, and Evolutionary Computation and IEEE ITS Magazine.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"275829",title:"Dr.",name:"Esther",middleName:null,surname:"Villar-Rodriguez",slug:"esther-villar-rodriguez",fullName:"Esther Villar-Rodriguez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/275829/images/system/275829.jpg",biography:"Dr. Esther Villar obtained a Ph.D. in Information and Communication Technologies from the University of Alcalá, Spain, in 2015. She obtained a degree in Computer Science from the University of Deusto, Spain, in 2010, and an MSc in Computer Languages and Systems from the National University of Distance Education, Spain, in 2012. Her areas of interest and knowledge include natural language processing (NLP), detection of impersonation in social networks, semantic web, and machine learning. Dr. Esther Villar made several contributions at conferences and publishing in various journals in those fields. Currently, she is working within the OPTIMA (Optimization Modeling & Analytics) business of TECNALIA’s ICT Division as a data scientist in projects related to the prediction and optimization of management and industrial processes (resource planning, energy efficiency, etc).",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"49813",title:"Dr.",name:"Javier",middleName:null,surname:"Del Ser",slug:"javier-del-ser",fullName:"Javier Del Ser",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49813/images/system/49813.png",biography:"Prof. Dr. Javier Del Ser received his first PhD in Telecommunication Engineering (Cum Laude) from the University of Navarra, Spain, in 2006, and a second PhD in Computational Intelligence (Summa Cum Laude) from the University of Alcala, Spain, in 2013. He is currently a principal researcher in data analytics and optimisation at TECNALIA (Spain), a visiting fellow at the Basque Center for Applied Mathematics (BCAM) and a part-time lecturer at the University of the Basque Country (UPV/EHU). His research interests gravitate on the use of descriptive, prescriptive and predictive algorithms for data mining and optimization in a diverse range of application fields such as Energy, Transport, Telecommunications, Health and Industry, among others. In these fields he has published more than 240 articles, co-supervised 8 Ph.D. theses, edited 6 books, coauthored 7 patents and participated/led more than 40 research projects. He is a Senior Member of the IEEE, and a recipient of the Biscay Talent prize for his academic career.",institutionString:"Tecnalia Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"278948",title:"Dr.",name:"Carlos Pedro",middleName:null,surname:"Gonçalves",slug:"carlos-pedro-goncalves",fullName:"Carlos Pedro Gonçalves",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRcmyQAC/Profile_Picture_1564224512145",biography:'Carlos Pedro Gonçalves (PhD) is an Associate Professor at Lusophone University of Humanities and Technologies and a researcher on Complexity Sciences, Quantum Technologies, Artificial Intelligence, Strategic Studies, Studies in Intelligence and Security, FinTech and Financial Risk Modeling. He is also a progammer with programming experience in:\n\nA) Quantum Computing using Qiskit Python module and IBM Quantum Experience Platform, with software developed on the simulation of Quantum Artificial Neural Networks and Quantum Cybersecurity;\n\nB) Artificial Intelligence and Machine learning programming in Python;\n\nC) Artificial Intelligence, Multiagent Systems Modeling and System Dynamics Modeling in Netlogo, with models developed in the areas of Chaos Theory, Econophysics, Artificial Intelligence, Classical and Quantum Complex Systems Science, with the Econophysics models having been cited worldwide and incorporated in PhD programs by different Universities.\n\nReceived an Arctic Code Vault Contributor status by GitHub, due to having developed open source software preserved in the \\"Arctic Code Vault\\" for future generations (https://archiveprogram.github.com/arctic-vault/), with the Strategy Analyzer A.I. module for decision making support (based on his PhD thesis, used in his Classes on Decision Making and in Strategic Intelligence Consulting Activities) and QNeural Python Quantum Neural Network simulator also preserved in the \\"Arctic Code Vault\\", for access to these software modules see: https://github.com/cpgoncalves. He is also a peer reviewer with outsanding review status from Elsevier journals, including Physica A, Neurocomputing and Engineering Applications of Artificial Intelligence. Science CV available at: https://www.cienciavitae.pt//pt/8E1C-A8B3-78C5 and ORCID: https://orcid.org/0000-0002-0298-3974',institutionString:"University of Lisbon",institution:{name:"Universidade Lusófona",country:{name:"Portugal"}}},{id:"241400",title:"Prof.",name:"Mohammed",middleName:null,surname:"Bsiss",slug:"mohammed-bsiss",fullName:"Mohammed Bsiss",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/241400/images/8062_n.jpg",biography:null,institutionString:null,institution:null},{id:"276128",title:"Dr.",name:"Hira",middleName:null,surname:"Fatima",slug:"hira-fatima",fullName:"Hira Fatima",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/276128/images/14420_n.jpg",biography:"Dr. Hira Fatima\nAssistant Professor\nDepartment of Mathematics\nInstitute of Applied Science\nMangalayatan University, Aligarh\nMobile: no : 8532041179\nhirafatima2014@gmal.com\n\nDr. Hira Fatima has received his Ph.D. degree in pure Mathematics from Aligarh Muslim University, Aligarh India. Currently working as an Assistant Professor in the Department of Mathematics, Institute of Applied Science, Mangalayatan University, Aligarh. She taught so many courses of Mathematics of UG and PG level. Her research Area of Expertise is Functional Analysis & Sequence Spaces. She has been working on Ideal Convergence of double sequence. She has published 17 research papers in National and International Journals including Cogent Mathematics, Filomat, Journal of Intelligent and Fuzzy Systems, Advances in Difference Equations, Journal of Mathematical Analysis, Journal of Mathematical & Computer Science etc. She has also reviewed few research papers for the and international journals. She is a member of Indian Mathematical Society.",institutionString:null,institution:null},{id:"414880",title:"Dr.",name:"Maryam",middleName:null,surname:"Vatankhah",slug:"maryam-vatankhah",fullName:"Maryam Vatankhah",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Borough of Manhattan Community College",country:{name:"United States of America"}}},{id:"414879",title:"Prof.",name:"Mohammad-Reza",middleName:null,surname:"Akbarzadeh-Totonchi",slug:"mohammad-reza-akbarzadeh-totonchi",fullName:"Mohammad-Reza Akbarzadeh-Totonchi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Ferdowsi University of Mashhad",country:{name:"Iran"}}},{id:"414878",title:"Prof.",name:"Reza",middleName:null,surname:"Fazel-Rezai",slug:"reza-fazel-rezai",fullName:"Reza Fazel-Rezai",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"American Public University System",country:{name:"United States of America"}}},{id:"426586",title:"Dr.",name:"Oladunni A.",middleName:null,surname:"Daramola",slug:"oladunni-a.-daramola",fullName:"Oladunni A. Daramola",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Federal University of Technology",country:{name:"Nigeria"}}},{id:"357014",title:"Prof.",name:"Leon",middleName:null,surname:"Bobrowski",slug:"leon-bobrowski",fullName:"Leon Bobrowski",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Bialystok University of Technology",country:{name:"Poland"}}},{id:"302698",title:"Dr.",name:"Yao",middleName:null,surname:"Shan",slug:"yao-shan",fullName:"Yao Shan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Dalian University of Technology",country:{name:"China"}}},{id:"354126",title:"Dr.",name:"Setiawan",middleName:null,surname:"Hadi",slug:"setiawan-hadi",fullName:"Setiawan Hadi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Padjadjaran University",country:{name:"Indonesia"}}},{id:"125911",title:"Prof.",name:"Jia-Ching",middleName:null,surname:"Wang",slug:"jia-ching-wang",fullName:"Jia-Ching Wang",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"National Central University",country:{name:"Taiwan"}}},{id:"332603",title:"Prof.",name:"Kumar S.",middleName:null,surname:"Ray",slug:"kumar-s.-ray",fullName:"Kumar S. Ray",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Indian Statistical Institute",country:{name:"India"}}},{id:"415409",title:"Prof.",name:"Maghsoud",middleName:null,surname:"Amiri",slug:"maghsoud-amiri",fullName:"Maghsoud Amiri",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Allameh Tabataba'i University",country:{name:"Iran"}}},{id:"357085",title:"Mr.",name:"P. Mohan",middleName:null,surname:"Anand",slug:"p.-mohan-anand",fullName:"P. Mohan Anand",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Indian Institute of Technology Kanpur",country:{name:"India"}}},{id:"356696",title:"Ph.D. Student",name:"P.V.",middleName:null,surname:"Sai Charan",slug:"p.v.-sai-charan",fullName:"P.V. Sai Charan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Indian Institute of Technology Kanpur",country:{name:"India"}}},{id:"357086",title:"Prof.",name:"Sandeep K.",middleName:null,surname:"Shukla",slug:"sandeep-k.-shukla",fullName:"Sandeep K. Shukla",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Indian Institute of Technology Kanpur",country:{name:"India"}}}]}},subseries:{item:{id:"18",type:"subseries",title:"Proteomics",keywords:"Mono- and Two-Dimensional Gel Electrophoresis (1-and 2-DE), Liquid Chromatography (LC), Mass Spectrometry/Tandem Mass Spectrometry (MS; MS/MS), Proteins",scope:"With the recognition that the human genome cannot provide answers to the etiology of a disorder, changes in the proteins expressed by a genome became a focus in research. Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. The Proteomics topic aims to attract contributions on all aspects of MS-based proteomics that, by pushing the boundaries of MS capabilities, may address biological problems that have not been resolved yet.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11414,editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",slug:"paolo-iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",biography:"Paolo Iadarola graduated with a degree in Chemistry from the University of Pavia (Italy) in July 1972. He then worked as an Assistant Professor at the Faculty of Science of the same University until 1984. In 1985, Prof. Iadarola became Associate Professor at the Department of Biology and Biotechnologies of the University of Pavia and retired in October 2017. Since then, he has been working as an Adjunct Professor in the same Department at the University of Pavia. His research activity during the first years was primarily focused on the purification and structural characterization of enzymes from animal and plant sources. During this period, Prof. Iadarola familiarized himself with the conventional techniques used in column chromatography, spectrophotometry, manual Edman degradation, and electrophoresis). Since 1995, he has been working on: i) the determination in biological fluids (serum, urine, bronchoalveolar lavage, sputum) of proteolytic activities involved in the degradation processes of connective tissue matrix, and ii) on the identification of biological markers of lung diseases. In this context, he has developed and validated new methodologies (e.g., Capillary Electrophoresis coupled to Laser-Induced Fluorescence, CE-LIF) whose application enabled him to determine both the amounts of biochemical markers (Desmosines) in urine/serum of patients affected by Chronic Obstructive Pulmonary Disease (COPD) and the activity of proteolytic enzymes (Human Neutrophil Elastase, Cathepsin G, Pseudomonas aeruginosa elastase) in sputa of these patients. More recently, Prof. Iadarola was involved in developing techniques such as two-dimensional electrophoresis coupled to liquid chromatography/mass spectrometry (2DE-LC/MS) for the proteomic analysis of biological fluids aimed at the identification of potential biomarkers of different lung diseases. He is the author of about 150 publications (According to Scopus: H-Index: 23; Total citations: 1568- According to WOS: H-Index: 20; Total Citations: 1296) of peer-reviewed international journals. He is a Consultant Reviewer for several journals, including the Journal of Chromatography A, Journal of Chromatography B, Plos ONE, Proteomes, International Journal of Molecular Science, Biotech, Electrophoresis, and others. He is also Associate Editor of Biotech.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",slug:"simona-viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",biography:"Simona Viglio is an Associate Professor of Biochemistry at the Department of Molecular Medicine at the University of Pavia. She has been working since 1995 on the determination of proteolytic enzymes involved in the degradation process of connective tissue matrix and on the identification of biological markers of lung diseases. She gained considerable experience in developing and validating new methodologies whose applications allowed her to determine both the amount of biomarkers (Desmosine and Isodesmosine) in the urine of patients affected by COPD, and the activity of proteolytic enzymes (HNE, Cathepsin G, Pseudomonas aeruginosa elastase) in the sputa of these patients. Simona Viglio was also involved in research dealing with the supplementation of amino acids in patients with brain injury and chronic heart failure. She is presently engaged in the development of 2-DE and LC-MS techniques for the study of proteomics in biological fluids. The aim of this research is the identification of potential biomarkers of lung diseases. She is an author of about 90 publications (According to Scopus: H-Index: 23; According to WOS: H-Index: 20) on peer-reviewed journals, a member of the “Società Italiana di Biochimica e Biologia Molecolare,“ and a Consultant Reviewer for International Journal of Molecular Science, Journal of Chromatography A, COPD, Plos ONE and Nutritional Neuroscience.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null,series:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983"},editorialBoard:[{id:"72288",title:"Dr.",name:"Arli Aditya",middleName:null,surname:"Parikesit",slug:"arli-aditya-parikesit",fullName:"Arli Aditya Parikesit",profilePictureURL:"https://mts.intechopen.com/storage/users/72288/images/system/72288.jpg",institutionString:null,institution:{name:"Indonesia International Institute for Life Sciences",institutionURL:null,country:{name:"Indonesia"}}},{id:"40928",title:"Dr.",name:"Cesar",middleName:null,surname:"Lopez-Camarillo",slug:"cesar-lopez-camarillo",fullName:"Cesar Lopez-Camarillo",profilePictureURL:"https://mts.intechopen.com/storage/users/40928/images/3884_n.png",institutionString:null,institution:{name:"Universidad Autónoma de la Ciudad de México",institutionURL:null,country:{name:"Mexico"}}},{id:"81926",title:"Dr.",name:"Shymaa",middleName:null,surname:"Enany",slug:"shymaa-enany",fullName:"Shymaa Enany",profilePictureURL:"https://mts.intechopen.com/storage/users/81926/images/system/81926.png",institutionString:"Suez Canal University",institution:{name:"Suez Canal University",institutionURL:null,country:{name:"Egypt"}}}]},onlineFirstChapters:{paginationCount:26,paginationItems:[{id:"83087",title:"Role of Cellular Responses in Periodontal Tissue Destruction",doi:"10.5772/intechopen.106645",signatures:"Nam Cong-Nhat Huynh",slug:"role-of-cellular-responses-in-periodontal-tissue-destruction",totalDownloads:8,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Periodontology - New Insights",coverURL:"https://cdn.intechopen.com/books/images_new/11566.jpg",subseries:{id:"1",title:"Oral Health"}}},{id:"82654",title:"Atraumatic Restorative Treatment: More than a Minimally Invasive Approach?",doi:"10.5772/intechopen.105623",signatures:"Manal A. Ablal",slug:"atraumatic-restorative-treatment-more-than-a-minimally-invasive-approach",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Dental Caries - The Selection of Restoration Methods and Restorative Materials",coverURL:"https://cdn.intechopen.com/books/images_new/11565.jpg",subseries:{id:"1",title:"Oral Health"}}},{id:"82735",title:"The Influence of Salivary pH on the Prevalence of Dental Caries",doi:"10.5772/intechopen.106154",signatures:"Laura-Cristina Rusu, Alexandra Roi, Ciprian-Ioan Roi, Codruta Victoria Tigmeanu and Lavinia Cosmina Ardelean",slug:"the-influence-of-salivary-ph-on-the-prevalence-of-dental-caries",totalDownloads:12,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Dental Caries - The Selection of Restoration Methods and Restorative Materials",coverURL:"https://cdn.intechopen.com/books/images_new/11565.jpg",subseries:{id:"1",title:"Oral Health"}}},{id:"82357",title:"Caries Management Aided by Fluorescence-Based Devices",doi:"10.5772/intechopen.105567",signatures:"Atena Galuscan, Daniela Jumanca and Aurora Doris Fratila",slug:"caries-management-aided-by-fluorescence-based-devices",totalDownloads:6,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Dental Caries - The Selection of Restoration Methods and Restorative Materials",coverURL:"https://cdn.intechopen.com/books/images_new/11565.jpg",subseries:{id:"1",title:"Oral Health"}}},{id:"81894",title:"Diet and Nutrition and Their Relationship with Early Childhood Dental Caries",doi:"10.5772/intechopen.105123",signatures:"Luanna Gonçalves Ferreira, Giuliana de Campos Chaves Lamarque and Francisco Wanderley Garcia Paula-Silva",slug:"diet-and-nutrition-and-their-relationship-with-early-childhood-dental-caries",totalDownloads:20,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Dental Caries - The Selection of Restoration Methods and Restorative Materials",coverURL:"https://cdn.intechopen.com/books/images_new/11565.jpg",subseries:{id:"1",title:"Oral Health"}}},{id:"80964",title:"Upper Airway Expansion in Disabled Children",doi:"10.5772/intechopen.102830",signatures:"David Andrade, Joana Andrade, Maria-João Palha, Cristina Areias, Paula Macedo, Ana Norton, Miguel Palha, Lurdes Morais, Dóris Rocha Ruiz and Sônia Groisman",slug:"upper-airway-expansion-in-disabled-children",totalDownloads:44,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Oral Health Care - An Important Issue of the Modern Society",coverURL:"https://cdn.intechopen.com/books/images_new/10827.jpg",subseries:{id:"1",title:"Oral Health"}}},{id:"80839",title:"Herbs and Oral Health",doi:"10.5772/intechopen.103715",signatures:"Zuhair S. Natto",slug:"herbs-and-oral-health",totalDownloads:70,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Oral Health Care - An Important Issue of the Modern Society",coverURL:"https://cdn.intechopen.com/books/images_new/10827.jpg",subseries:{id:"1",title:"Oral Health"}}},{id:"80441",title:"Periodontitis and Heart Disease: Current Perspectives on the Associative Relationships and Preventive Impact",doi:"10.5772/intechopen.102669",signatures:"Alexandra Roman, Andrada Soancă, Bogdan Caloian, Alexandru Bucur, Gabriela Valentina Caracostea, Andreia Paraschiva Preda, Dora Maria Popescu, Iulia Cristina Micu, Petra Șurlin, Andreea Ciurea, Diana Oneț, Mircea Viorel Ciurea, Dragoș Alexandru Țermure and Marius Negucioiu",slug:"periodontitis-and-heart-disease-current-perspectives-on-the-associative-relationships-and-preventive",totalDownloads:66,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Oral Health Care - An Important Issue of the Modern Society",coverURL:"https://cdn.intechopen.com/books/images_new/10827.jpg",subseries:{id:"1",title:"Oral Health"}}},{id:"79498",title:"Oral Aspects and Dental Management of Special Needs Patient",doi:"10.5772/intechopen.101067",signatures:"Pinar Kiymet Karataban",slug:"oral-aspects-and-dental-management-of-special-needs-patient",totalDownloads:116,totalCrossrefCites:0,totalDimensionsCites:0,authors:[{name:"Pinar",surname:"Karataban"}],book:{title:"Oral Health Care - An Important Issue of the Modern Society",coverURL:"https://cdn.intechopen.com/books/images_new/10827.jpg",subseries:{id:"1",title:"Oral Health"}}},{id:"79699",title:"Metabolomics Distinction of Cigarette Smokers from Non-Smokers Using Non-Stationary Benchtop Nuclear Magnetic Resonance (NMR) Analysis of Human Saliva",doi:"10.5772/intechopen.101414",signatures:"Benita C. Percival, Angela Wann, Sophie Taylor, Mark Edgar, Miles Gibson and Martin Grootveld",slug:"metabolomics-distinction-of-cigarette-smokers-from-non-smokers-using-non-stationary-benchtop-nuclear",totalDownloads:56,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Oral Health Care - An Important Issue of the Modern Society",coverURL:"https://cdn.intechopen.com/books/images_new/10827.jpg",subseries:{id:"1",title:"Oral Health"}}},{id:"80295",title:"Preventive Methods and Treatments of White Spot Lesions in Orthodontics",doi:"10.5772/intechopen.102064",signatures:"Elif Nadide Akay",slug:"preventive-methods-and-treatments-of-white-spot-lesions-in-orthodontics",totalDownloads:89,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Oral Health Care - An Important Issue of the Modern Society",coverURL:"https://cdn.intechopen.com/books/images_new/10827.jpg",subseries:{id:"1",title:"Oral Health"}}},{id:"79876",title:"Management and Prevention Strategies for Treating Dentine Hypersensitivity",doi:"10.5772/intechopen.101495",signatures:"David G. Gillam",slug:"management-and-prevention-strategies-for-treating-dentine-hypersensitivity",totalDownloads:94,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Oral Health Care - An Important Issue of the Modern Society",coverURL:"https://cdn.intechopen.com/books/images_new/10827.jpg",subseries:{id:"1",title:"Oral Health"}}},{id:"80020",title:"Alternative Denture Base Materials for Allergic Patients",doi:"10.5772/intechopen.101956",signatures:"Lavinia Cosmina Ardelean, Laura-Cristina Rusu and Codruta Victoria Tigmeanu",slug:"alternative-denture-base-materials-for-allergic-patients",totalDownloads:198,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Oral Health Care - An Important Issue of the Modern Society",coverURL:"https://cdn.intechopen.com/books/images_new/10827.jpg",subseries:{id:"1",title:"Oral Health"}}},{id:"79297",title:"Oral Health and Prevention in Older Adults",doi:"10.5772/intechopen.101043",signatures:"Irma Fabiola Díaz-García, Dinorah Munira Hernández-Santos, Julio Alberto Díaz-Ramos and Neyda Ma. Mendoza-Ruvalcaba",slug:"oral-health-and-prevention-in-older-adults",totalDownloads:113,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Oral Health Care - An Important Issue of the Modern Society",coverURL:"https://cdn.intechopen.com/books/images_new/10827.jpg",subseries:{id:"1",title:"Oral Health"}}},{id:"79903",title:"Molecular Docking of Phytochemicals against Streptococcus mutans Virulence Targets: A Proteomic Insight into Drug Planning",doi:"10.5772/intechopen.101506",signatures:"Diego Romário da Silva, Tahyná Duda Deps, Otavio Akira Souza Sakaguchi, Edja Maria Melo de Brito Costa, Carlus Alberto Oliveira dos Santos, Joanilda Paolla Raimundo e Silva, Bruna Dantas da Silva, Frederico Favaro Ribeiro, Francisco Jaime Bezerra Mendonça-Júnior and Andréa Cristina Barbosa da Silva",slug:"molecular-docking-of-phytochemicals-against-em-streptococcus-mutans-em-virulence-targets-a-proteomic",totalDownloads:114,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Oral Health Care - An Important Issue of the Modern Society",coverURL:"https://cdn.intechopen.com/books/images_new/10827.jpg",subseries:{id:"1",title:"Oral Health"}}},{id:"79754",title:"Evaluation of Trans-Resveratrol as a Treatment for Periodontitis",doi:"10.5772/intechopen.101477",signatures:"Tracey Lynn Harney",slug:"evaluation-of-trans-resveratrol-as-a-treatment-for-periodontitis",totalDownloads:112,totalCrossrefCites:1,totalDimensionsCites:1,authors:null,book:{title:"Oral Health Care - An Important Issue of the Modern Society",coverURL:"https://cdn.intechopen.com/books/images_new/10827.jpg",subseries:{id:"1",title:"Oral Health"}}}]},publishedBooks:{paginationCount:1,paginationItems:[{type:"book",id:"11392",title:"Leadership in a Changing World",subtitle:"A Multidimensional Perspective",coverURL:"https://cdn.intechopen.com/books/images_new/11392.jpg",slug:"leadership-in-a-changing-world-a-multidimensional-perspective",publishedDate:"May 11th 2022",editedByType:"Edited by",bookSignature:"Muhammad Mohiuddin, Bilal Khalid, Md. Samim Al Azad and Slimane Ed-dafali",hash:"86a6d33cf601587e591064ce92effc02",volumeInSeries:1,fullTitle:"Leadership in a Changing World - A Multidimensional Perspective",editors:[{id:"418514",title:"Dr.",name:"Muhammad",middleName:null,surname:"Mohiuddin",slug:"muhammad-mohiuddin",fullName:"Muhammad Mohiuddin",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038UqSfQAK/Profile_Picture_2022-05-13T10:39:03.jpg",institutionString:"Université Laval",institution:{name:"Université Laval",institutionURL:null,country:{name:"Canada"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},testimonialsList:[{id:"8",text:"I work with IntechOpen for a number of reasons: their professionalism, their mission in support of Open Access publishing, and the quality of their peer-reviewed publications, but also because they believe in equality.",author:{id:"202192",name:"Catrin",surname:"Rutland",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",slug:"catrin-rutland",institution:{id:"134",name:"University of Nottingham",country:{id:null,name:"United Kingdom"}}}},{id:"27",text:"The opportunity to work with a prestigious publisher allows for the possibility to collaborate with more research groups interested in animal nutrition, leading to the development of new feeding strategies and food valuation while being more sustainable with the environment, allowing more readers to learn about the subject.",author:{id:"175967",name:"Manuel",surname:"Gonzalez Ronquillo",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/175967/images/system/175967.png",slug:"manuel-gonzalez-ronquillo",institution:{id:"6221",name:"Universidad Autónoma del Estado de México",country:{id:null,name:"Mexico"}}}},{id:"18",text:"It was great publishing with IntechOpen, the process was straightforward and I had support all along.",author:{id:"71579",name:"Berend",surname:"Olivier",institutionString:"Utrecht University",profilePictureURL:"https://mts.intechopen.com/storage/users/71579/images/system/71579.png",slug:"berend-olivier",institution:{id:"253",name:"Utrecht University",country:{id:null,name:"Netherlands"}}}}]},submityourwork:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:108,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:141,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:124,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:22,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:11,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],subseriesList:[{id:"3",title:"Bacterial Infectious Diseases",scope:"