IntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
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IntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
With the desire to make book publishing more relevant for the digital age and offer innovative Open Access publishing options, we are thrilled to announce the launch of our new publishing format: IntechOpen Book Series.
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Designed to cover fast-moving research fields in rapidly expanding areas, our Book Series feature a Topic structure allowing us to present the most relevant sub-disciplines. Book Series are headed by Series Editors, and a team of Topic Editors supported by international Editorial Board members. Topics are always open for submissions, with an Annual Volume published each calendar year.
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After a robust peer-review process, accepted works are published quickly, thanks to Online First, ensuring research is made available to the scientific community without delay.
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Our innovative Book Series format brings you:
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Topic Focused Publications - Each topic showcases high impact subject areas
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Renowned Editorial Expertise - Series Editors, Topic Editors, and a team of international Board Members that permanently support each Book Series
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Fast Publishing - quick turnaround which is unique for book publishing
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The benefit of ISSN and ISBN for increased citation and indexing possibilities
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IntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\n\n
IntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
We invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
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Note: Edited in October 2021
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\r\n\tMuscular dystrophies are a group of genetic conditions primarily characterized by progressive muscle weakness and degeneration of the skeletal muscles. To date, more than 30 types of muscular dystrophies are described and classified based on their clinical phenotype, genetic defect, and protein involved, but many others remain to be characterized and classified. Overlapping clinical symptoms and the multitude of genes to be analyzed for an accurate diagnosis make it difficult to identify the type of dystrophy. The continuous evolution of molecular techniques and the accumulation of knowledge about the pathophysiology of these diseases have led to improved accuracy of diagnosis and approach to different therapeutic strategies.
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\r\n\tThis book will aim to provide an overview of the recent advances in the muscular dystrophy field, addressing the cellular and molecular basis of muscular dystrophy, biomarkers, available animal models for research, diagnostic methods, and the newest therapeutic strategies related to these diseases.
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1. Introduction
Mostly single crystals of semiconductors, dielectrics, metals, or alloys are produced in the process of crystallization or solidification from the melt. The rates of crystallization can reach tens of millimeters per minute. During crystallization in single crystals, structural defects can be collected, that have a negative effect on the mechanical and other properties of materials. High demands for structural perfection and chemical purity of single crystals caused considerable research efforts aimed at the study and improvement of the main techniques of growing single crystals from the melt (Czochralski, Stepanov, Bridgman, Verneuil, floating zone). Single crystals of refractory bcc metals, especially molybdenum and tungsten, are widely used in several areas of modern technology, such as nuclear energy, electronics, lighting fixtures, mainly for the manufacture of parts and devices (anodes, cathodes, etc.) working at high temperatures. A scope of single crystals of refractory metals is continuously expanding, and requirements for chemical purity of crystals, their structural quality and geometry are constantly growing. Currently, the most pure single crystals of molybdenum and tungsten, as well of a number of other refractory metals can be produced by electron-beam floating zone melting (EBFZM). However, their crystallographic perfection due to the specific features of the floating zone method with electron-beam heating, often no longer satisfies the developers of new instruments and devices. A characteristic blocky structure and a high density of dislocations make such crystals unsuitable, for example, for research of channeling high-energy particles or posing a number of other subtle physical experiments. Further increase in a degree of purity and crystallographic perfection of single crystals of refractory metals is closely related to a development of theoretical and experimental researches of crystallization processes, the development of new apparatuses and methods for producing single crystals, as well as optimization of known processes. Therefore, to obtain additional information about the laws of formation of a dislocation structure, an impact on specific parameters of crystal growth in the floating zone method seems to be relevant scientific and technical challenge. The basis of this decision is a study of peculiarities of structural defects in single crystals grown by crystallization, which is one of the fundamental problems of solid state physics, physical chemistry, and theory of phase transitions.
2. Basic physical features of crystallization
2.1. Methods of growing single crystals from the melt
For growing oriented single crystals of semiconductors and dielectrics Czochralski method became widespread [1-3]. The essence of the method consists in pulling of single crystals by seeding at a surface of the melt. Although this method of capillary formation is known by its low stability, at high precision heating control and automation of pulling [4-6] it allows obtaining such semiconductors as silicon and germanium which are widely used in modern technology. Bridgman method, which also refers to the crucible methods similar to Czochralski, is used in a much smaller scale and mostly for growing single crystals of low-temperature melting metals. This is due to the fact that at high temperatures there are significant difficulties in finding materials for crucibles. Another widely used technique is Stepanov method of growing single crystals. Its difference from Czochralski consists in that the shaper is immersed into the melt, providing not only pulling cylindrical rods, but also production of a wide assortment of shaped crystals (tapes, tubes, polyhedrons, and other crystals of a complex shape). Stepanov method has much greater margins of stability during capillary shaping than Czochralski, which accounts for its wide distribution. However, for growing single crystals of refractory metals, especially molybdenum and tungsten, the above-mentioned methods are not suitable, as the high melting temperature and high chemical reactivity of liquid refractory metals do not allow obtaining them by any crucible method. The actual process of the growth is desirable to maintain in a vacuum or in an inert gas. For refractory metals Verneuil method is also used provided with another kind of a heater as plasma. This method yielded the most by large-scale tungsten single crystals of 40 mm in diameter and weighing up to 10 kg [7]. However, those single crystals were of poor structural quality and had high gas content, especially of a plasma gas. The most perfect single crystals of refractory metals can be obtained by electron-beam floating zone melting. The growth of these crystals is characterized by the fact that the method is a crucible-less one and a melt has no any contact with other materials. The melt is supported by forces of surface tension and the process is carried out in UHV. A phase diagram can give information on the type, number and volume fraction of phases at crystal growing from the melt [8]. This is true only in the case when crystallization proceeds at an infinitesimal rate. In practice, a finite rate and solidification conditions are far from thermodynamic equilibrium. Thus, binary alloy solidification occurs with enrichment or depletion of solid with a dissolved component. When impurity accumulation exceeds some critical value and a temperature gradient in liquid is reduced below a critical level, there comes concentration supercooling and the interphase surface changes from cellular to dendritic. This is nonequilibrium solidification and is typical of most alloys. A main feature of such solidification is that a primary axis of dendrites is strictly parallel to a heat flow direction and interdendritic spaces are enriched with impurities. This segregation further can be partially eliminated by prolonged high-temperature annealing. In some cases, there may be precipitates of a second phase in interdendritic spaces. When crystal growth conditions are such that a part of a two-phase zone is large and a growth rate is high, so that the factor is a lot less than zero: G-VFReff(1/D)≪0,where, G the temperature gradient in fluid; V the growth rate; (FR)eff the effective solidification range; D the diffusion coefficient. Thus, there is a porosity which may occur even in growing single crystals of pure refractory metals by EBFZM. It occurs especially after the first liquid zone passage during purifying the initial PM feed and growing a single crystal from. EBFZM provides not only a given orientation of crystal growth, but also due to refining by a zone effect mainly from substitution impurities. Refining of interstitial impurities occurs mainly by vacuum evaporation, the more that the melting points of refractory metals are very high. Impurities in a growing crystal often are undesirable as adversely affecting its structure and properties. In the process of accumulation of impurities before moving crystallization front, the plane crystallization front may become unstable due to so-called phenomenon of concentration supercooling. Impurities will greatly impair the dislocation substructure and unevenly distributed in a radial direction and a length of the crystal along the growth axis.
2.2. Mechanisms of crystallization of metals
Crystallization processes are widely used in modern science and technology: the growth of single crystals, production of pure substances by directional crystallization and zone melting. Crystallization in metallurgy - is one of the stages of producing metals, such as crystallization in molds, continuous casting, and processes in molds during refining. Currently, by theory of crystallization the following molecular mechanisms of the crystal growth are developed: nucleus, spiral, normal, continuous [1,2]. The crystal growth by two-dimensional nucleation leads to an expression for the growth rate:
v=Cexp-U/kTexp-A/kT,E1
\n\t\t\t\t
where, A the work of two-dimensional nucleation; U the activation energy of the atom addition to the brink of the nuclei; C the kinetic coefficient, which is first analyzed in [9,10]. It should be noted that much more other growth mechanisms implemented. Thus, the crystals containing dislocations cannot be grown by two-dimensional nucleation. A spiral stage formed near an exit of the dislocation on the crystal surface plays a role of non-vanishing two-dimensional nucleation, which facilitates the connection of new particles to the crystal. This theory gives an expression for the crystal growth rate in the following form [2]: v=DL∆T/4πrT02, where, D the diffusion coefficient; ΔT the supercooling; L the heat of crystallization; T0 the melting point. Two-face growth mechanisms in a tangential direction are implemented in practice. A condition for the growth by these mechanisms is the presence of an atomically smooth surface that holds only for substances with high heat of fusion and areas with low crystallographic indices. Crystals with low heat of fusion, which include almost all metals, have atomically rough edges; their micro relief varies continuously over time. Micro fluctuations of the atomic structure of the interface lead to active participation of all points on the surface of the crystal, and for all metalsL/kT0<2. Thus, metals are characterized by a normal growth mechanism. This mechanism is used for all values of supercooling, and specifically in the field of small deviations from equilibrium state of the system it becomes predominant. A normal mechanism is related to thermal fluctuations at the interface and therefore has greater sensitivity to small differences in temperature. According to theory of continuous growth, crystals in the neighborhood of equilibrium can grow exclusively through nucleation at the interface. Disadvantage of this theory is neglecting thermal fluctuations of the equilibrium type on the interphase between solid and liquid phases. This leads to the fact that the growth rate is described by quadratic or exponential functions which is characteristic of classical theories. Considered mechanisms of the crystal growth are characteristic for most typical cases of the free growth, i.e., when nothing prevents the crystal growing in either direction. However, in Czochralski and floating zone one has to deal with cases of the stimulated growth.
2.3. Heat and mass transfer processes in crystal growth from the melt
When moving the crystallization front in the melts a set of complex physical and chemical processes occur: heat transfer and mass transfer in the melt and crystal, oust impurities processes and impurity redistribution at the crystallization front, capillary phenomena, and metal evaporation. Under these conditions, the most important and crucial for the structural quality of the growing crystal is the temperature gradient in the liquid and solid phases (G=(∂T/∂n)S,L). Temperature gradients (K mm-1) occur at the crystallization front and are defined by intensity of a heat sink, chemical composition of the metal, release of crystallization heat, a heat input to the liquid metal, and convective flows in the melt [11]. In principle, stability of the crystallization process and quality of the single crystals grown are mostly influenced by the temperature field in the thermal zone of the growth set-ups, i.e., the temperature field in the crystal and melt. Of particular importance are temperature conditions at the crystallization front. A heat balance at the interface looks like:
λL(∂T/∂n)L+Lγv=λS(∂T/∂n)S,E2
\n\t\t\t\t
where, v the rate of crystallization; L the latent heat of crystallization; γ the melt density, kg m-3; λL,λS the thermal conductivity of the liquid and solid phases, W cm-1 K-1; n the normal to the surface of the interface;(∂T/∂n)S and (∂T/∂n)Lthe temperature gradients near the crystallization front. In simplified calculations suggest the phase boundary plane and then (∂T/∂n)=\n\t\t\t\t\t(∂T/∂z),which are the axial temperature gradients. The temperature field in the growing crystal also has a significant impact on its structure. The main cause of dislocations in the crystal is plastic deformation caused by thermal stresses which are typically caused by uneven cooling the crystal in the region of loss of plastic properties of material. The lower(∂T/∂n)S for the growing crystal, the more perfect is its structure; a low value means a lower productivity of the process. Indeed, if we take (∂T/∂n)L= 0, we obtain:
vmax=λS/Lγ(∂T/∂n)S,E3
\n\t\t\t\t
Now, if we assume that a heat transfer from the surface of the crystal is carried out mainly by radiation, we obtain:
vmax=1/Lγ4λSσ0εT0S/3d0.E4
\n\t\t\t\t
Where, T0 the crystallization temperature, K; σ0 = 5.67x10-12, W cm-2 K-4, the Stefan-Boltzmann constant; ε the emissivity of surface radiation of the crystal; d0 the crystal diameter, cm. A significant impact on the structure of the growing single crystal has a shape of the interface crystal-melt, which can be considered as the isothermal surface having a temperature of solidification. The most favorable form of the crystallization front is flat or somewhat convex to the melt [12,13]. This reduces the number of defects formed and contributes to their more uniform distribution in the crystal. For example, dislocation-free silicon single crystals are grown under the conditions of the crystallization front of forms close to a plane. The power needed to produce a molten zone of a predetermined shape is studied using a simplified model [14]. It is shown that Laplace\'s equation can describe the temperature changes along the rod and in the zone with a help of numerical methods. It is also found that the temperature distribution is characterized by several dimensionless Bio numbers, representing the ratio of the thermal conductivities in the liquid and solid phases, ratio between the length of the rod and width of the molten zone along the radius of the crystal, and power. The resulting temperature distribution and forms of the liquid zone for different Biot numbers and coefficients of thermal conductivity obtained as functions of the energy supplied to the zone. A horizontality of isotherms near the solidification front decreases the radial gradient and thus stabilizes the axial gradient(∂T/∂n). As for the value of the latter, on this account, there are conflicting opinions. On the one hand, increased (∂T/∂z)L near the phase boundary promotes better ousting impurities, improve stability of the crystallization process, increase the growth rate, reducing a likelihood of spontaneous crystallization due to concentration supercooling. On the other hand, excessive (∂T/∂z)L at the interface causes increasing convective flows; this can lead to uncontrolled temperature fluctuations near the crystallization front. The latter circumstance causes a very common defect in crystals – a streaky micro inhomogeneity of impurities [15]. In addition to the temperature distribution near the crystallization front in the vicinity of the phase boundary, the temperature field is also important in a whole volume of the melt, as a prerequisite exception of spontaneous crystallization is overheating the melt outside the phase boundary. The temperature field in the entire volume of the melt determines existing natural convection flows. It is also important obtaining an axial symmetry of the temperature field. When growing semiconductors, it is necessary to reproduce temperature gradients with accuracy of ±0.50 C cm-1 in certain areas of the thermal processing zone. Of particular note is the fact that the temperature field in the crystal and in the melt cannot be considered outside the context of each other. Adjustment of the temperature field in the crystal will cause changes of the temperature field in the melt (opposite is also true). This makes it difficult to control when growing. The technological practice (primarily for growing semiconductor crystals) shows that for high-quality single crystals with desired properties it is necessary to accurately maintain the set of the temperature mode in time. A tough time maintaining the temperature field should be of the high-precision and high-rate automatic control system. The most important is to maintain the constant temperature in time at the crystallization front. The main factors disturbing the thermal regime are oscillations of the power input and fluctuations of the heat loss. The latter means impermanence of the cooling water to elements of a design as well a variable heat removal through the growing crystal. In some cases, to eliminate disturbances associated with a change in internal conditions it is necessary to make corrections in advance by changing the computer programmed temperature. In this case allowable temperature fluctuations in obtaining perfect semiconductor crystals should not exceed 0.10 C. Instabilities of the temperature lead to the increased dislocations density, but in some cases of more serious defects (twins, portions of the polycrystalline structure, etc.). In addition, the structural quality of single crystals affects by the rate of the zone movement and its fluctuations. With increase in the rate, the dislocation density is greatly increased. This limit for niobium is of 0.5 mm min-1. From perspectives of influence on the structure, the zone movement rate must be stable up to about 1%, and all kinds of vibration should be excluded.
2.4. Influence of convection in the melt on the crystal structure
In recent years, an interest has grown significantly to convective phenomena in the melt during the growth of single crystals. In particular, this is due to the possibility of conducting experiments in space. A large number of studies on convection in the melt during the growth of single crystals were done by various methods. Hydrodynamic phenomena are typical of the floating zone method [13-15]. It should be noted that phenomena of convection are studied by two ways: convective phenomena experimentally investigated by physical modeling of the crystal growth in transparent liquids and by constructing mathematical and computer models. Mathematical models tend to represent a complex system of differential equations. Main assumptions in constructing models are stationary, two-dimensional and axisymmetric of the hydrodynamic problem [13]. Characteristic of models is the extensive use of dimensionless criteria of similarity theory. Particular attention is paid to thermocapillary convection (Marangoni convection) [15]. Results of model experiments and calculations are used to explain some properties of single crystals of molybdenum, so that study is considered in more detail. Convective flows in the melt can have a significant impact on the structure and properties of the growing single crystal. Important parameters such as impurities and the concentration and temperature gradients in the melt are dependent on nature of flows. The shape of the crystal-melt interface appears to depend not only on heat transfer processes, but also on conditions of the melt flows. Consider the most important similarity criteria which give a relation between the convective and diffusive heat and mass transfer. It is accordingly Prandtl Pr = θ/φ and Schmidt Sc = θ/D, where θ the kinematic viscosity of the melt; D the diffusion coefficient; φ the thermal diffusivity. For typical metallic melts Pr « 1, Sc » 1, i.e., the heat transfer occurs mainly by conduction, and the impurity transfer occurs by convection which plays a significant role. Therefore, it can be expected that microsegregation in the crystal melt is associated with hydrodynamics of the melt. The experiments were done by EBFZM of molybdenum with additives of iridium-192 (K0 = 0.37) and tungsten (K0 = 50). X-ray topograms and autoradiograms of longitudinal cross-sections of samples showed characteristic bands enriched with impurities. If we assume that the melt is the incompressible fluid, the density of which depends on the temperature and impurity content, the forces, that give rise to convective flows in the melt, are the following: gravitational forces (cause natural convection), capillary forces (cause Marangoni convection) and inertial forces (occur when the crystal is rotated). In general, flow patterns in the molten zone are the result of the joint effect of these forces. Before discussing the problem of convection we should consider features of the temperature distribution in the molten zone. The interfacial crystal-melt surface at the crystallization front has a temperature T0. The maximum temperature T0\n\t\t\t\t\t+ ΔT is in the middle of the zone, i.e., there is the positive axial temperature gradient. Furthermore, there is the negative radial gradient directed from the periphery toward the center of the zone. Arising under these conditions vertical density gradients, causing steady natural convection, can be described by Rayleigh numbers Ra=αg∆Th3/ϑφ~103, where, g the acceleration due to gravity; α the coefficient of thermal expansion; h the half a zone length. As for radial temperature gradients, they correspond to Rayleigh numbers, almost equal to zero. Acting on the free surface of the melt the surface tension forces are functions of temperature, σ = f (T). If on the free melt surface the temperature gradient exists, resulting in changes in surface energy, then capillary Marangoni forces begin to act. These forces give rise to characteristic convection in the melt. The rate of flows caused by Marangoni forces is greatest at the surface of the melt. With increasing the distance from the surface the rate decreases and then changes its sign. In the case of the zone melting Marangoni forces act on the periphery of the zone from its middle to interphase boundaries. The power of Marangoni forces is characterized by Marangoni numbers Ma=∂σ/∂TΔTh2/ρυφ, where, |∂σ/∂T| is the temperature coefficient of surface tension; ρ the density of the melt. The ratio of Rayleigh number to Marangoni number characterizes the ratio of forces of free convection and Marangoni convection: Bo=Ra/Ma=gραh2/∂σ/∂T. When Bo < 1, Marangoni flow dominates in the melt. It takes place in normal gravity when h ≤ 1 cm [15]. In the absence of rotation, Marangoni flow in the melt is toroidal axially symmetric. With increasing Bo outer vortices increasingly dominate over the lower ones. This leads to the non-uniform transfer of impurities in the melt and eventually to the radial non-uniformity of impurities. Increase in the dislocation density in the crystal can be explained by the interfacial surface curvature produced by convection. At Ma>3.4x103 flows become unstable. There are variations in the temperature within the melt with a frequencyf~h-1d-1, where d is the diameter of the crystal. This leads to such defects in the crystal as impurity bands which is found at the respective longitudinal sections of the X-ray topographs [15]. The width of the bands associated with the zone and the rate of the oscillation frequency f: a=v/f, where, v is the growth rate; a is the width of the band. Temperature fluctuations lead to reduction of Keff and further to macrosegregation. The banded heterogeneity may disappear at growth rates below a certain critical value due to fairly good diffusion in the solid phase. We must also mention the detected submicroporosity in molybdenum single crystals grown by EBFZM after the first and second zone runs. These submicropores of diameter 0.3-0.5 micron decorate the interphase boundary and are also associated with temperature oscillation, because arranged by bands and seen on cleaved samples in scanning electron microscope.
2.5. Thermal stresses and dislocation structure of single crystals
For the first time in 1958, Dash [16] has grown dislocation-free silicon single crystals from the melt using the method of a narrow waist or a neck. He believed that dislocations appeared from the seed in the waist region, come to the surface, and stresses, occurring during further growth, cannot generate dislocations, if initially they did not exist in the crystal. Since dislocation defects are non-equilibrium, they may only be a consequence of non-equilibrium growth conditions. According to [1,2,15], for the formation of dislocations are responsible: external stresses of mechanical origin; thermal stresses; local stresses due to concentration gradients; condensation of vacancies; local stresses due to inclusions; errors during growth. Thermal stresses, occurring during the growth of single crystals from the melt, lead to significant increase in the dislocation density. Application of dislocation theory and theory of internal stresses to the problem of the crystal growth has led to significant achievements. It is shown that the main source of stresses causing deformation and dislocation multiplication in the growing crystal is the inhomogeneous temperature field. Thus, in the case of growing the single crystal of the radius R by crystallization from the melt, the following estimate for an absolute value arising from thermal stresses in the crystal: τ=kαER2Tz\'\', where, α is the coefficient of linear expansion; k is the coefficient; E is the Young\'s modulus; R is the radius of the crystal; Tz\'\' is the second derivative of the temperature by a coordinate z. From this it follows that the crystal growth is necessary to strive to ensure that the temperature field in the growing crystal should be as close as possible to the linear one, so Tz\'\' would be minimal. A number of experiments in growing single crystals of germanium show that in a case of active shielding (heated screens) it was succeeded by significantly reduce of the amount of Tz\'\' down to values of an order of 0.05 K mm-2. Due to this, the dislocation density has been reduced by almost two orders of magnitude. Admissible a following upper estimate for the density of dislocations arising from thermal stresses: ρ≥αgradT/b, where, α is the coefficient of thermal expansion; b is the Burgers vector. Note that growing single crystals of metals with the low dislocation density is significantly harder than single crystals of semiconductors or dielectrics. This is due to the fact that elastic constants of metals go to zero much faster as the temperature approaches the melting point [9,10]. The structural perfection of single crystals grown from the melt is influenced not only by the temperature gradients themselves, but the important factor in this respect is the cooling rate which is implemented at the stage of the crystal growth itself, and then under cooling to room temperature [17]. An influence of growth conditions on the dislocation substructure of copper single crystals is investigated in [18]. At a regular control of the dislocation structure, the Cu[111] single crystals are grown from the melt at the rate of 0.2-120 mm min-1. Variation of the growth rate in this range had a little effect on the random growth of the dislocation density inside subgrains which was ~2x106 cm-2. With an increase in the growth rate an average size of subgrains is significantly reduced from 5x10-2 cm to 0.5x10-2 cm, and this decline is roughly proportional to the cooling rate of the crystal rising -0.5 in accordance with the model of the dislocation origin of sub-boundaries. On the basis of these experiments, the conclusion is made that the model of the sub-boundaries formation is valid, and impurities do not play any significant role in the formation of the substructure in copper single crystals of purity less than 99.999%.
3. Experimental
3.1. The set-ups for electron beam floating zone melting
History of the development of EBFZM method to produce refractory metals in the single-crystal form has more than seventy years [19,20]. Over the past thirty years there was a significant progress both in improving experimental techniques used for growing single crystals of refractory metals, and the study of their structure and properties. However, even the well-known and successful designs of the electron gun [19] and EBFZM set-ups did not allowed to conduct a lengthy process of growing and were “not-easy” to operate. Then, the most advanced electron-beam guns are presented in [21-24]. There have been developed and tested the original EBFZM set-ups for growing single crystals of refractory metals. In the design of these set-ups have been successfully resolved the main problems concerning the mechanisms of the movement of the cathode assembly, the electron gun, the power supply and others (Figure 1). Single crystals, bicrystals and tubular crystal of many transition and refractory metals were grown using the electron guns with the protected annular filament-cathode in EBFZM set-ups.
Figure 1.
EBFZM set-up (a) and scheme of a thermal zone (b).
A principle of operation of EBFZM set-ups with annular electron guns, in a certain extent, is similar to a function of the vacuum triode: the tungsten filament (cathode), the feed sample (anode), focusing electrodes (control grid), the melting chamber (housing). The voltage, current and power, which are consumed for melting the feed, refining the liquid metal and growing the single crystal, are determined not only by both the anode voltage and the current of the cathode filament, but also by the residual gas pressure in the cathode-anode gap. In EBFZM set-ups for operation of the electron gun is very important the gas release from the feed during melting. Any sudden rise in pressure due to the gas release, metal evaporation or local vacuum decay even to 10-1 Pa in the electron gun lead to avalanche of a low resistance of the anode-cathode system and even to complete destabilization of the electron gun. From the above there are basic requirements to EBFZM set-ups providing conditions for the stable zone melting: stability of the electron gun; stability of the power supply; perfection of moveable nodes; an impurity homogeneity of the feed, otherwise it can cause unpredictable sharp increase in pressure in the melting chamber. It should be noted that the most sensitive element of EBFZM set-ups is the electron gun, so the focus of this section will be paid to the designs of electron guns, which should create the optimal and stable over time temperature field. Electron guns in many EBFZM set-ups have some disadvantages that prevented widespread of the method and demanded a lot of efforts to correct them. Typically, the designs of all known guns are such that spatters and vapors of metal get to the cathode filament, thereby destabilizing functions of the gun, changing its power due to local decrease in emissivity of the cathode filament. This often leads to burnout of the cathode and to finish the growing process. Another disadvantage of existing electron guns is contamination of the feed and crystal by metal vapors from which the cathode is made (usually tungsten), and the electron gun itself. Such contamination is most likely when the cathode is located in "line of sight" visibility of the feed, which is typical for almost all designs of electron guns. At 2500K the rate of evaporation of tungsten is less than 2x10-10 g s-1 cm-2 and thermionic tungsten cathodes are sufficient to melt all metals. Three-electrode electron guns with a single accelerating electrode allow to stabilize power supplied to the zone and to eliminate variations of the temperature during the growing process. It was also assumed that accelerating electrodes could act as modulators of the anode current, which would maintain without inertia the given heat regime and have significant advantages compared with known control systems. Naturally, electron guns, in which the upper and lower borders of focusing are realized by mechanical devices, do not meet these requirements.
Benefits of both EBFZM set-ups and electron guns [20] compared to previous ones consisted in the fact that metal vapors and spatters cannot reach the cathode and the liquid zone because the cathode filament is outside of a "line of sight". Main criteria for using new guns in EBFZM set-ups are: simplicity of the design, as well as reliability of operation at high temperatures and intensive sputtering. The density of the electron flux from the filament (with the current leads nearby) is for 3-5 times higher as compared with the opposite side of the same filament (without the current leads nearby). Such asymmetry of electron fluxes is observed in all guns in which the ring filament is made of two semi-rings. The asymmetric distribution of the electron density causes an asymmetry of the temperature field in the liquid zone and, as a result, the asymmetry of heating of the growing crystal. By the way, this may be one of reasons for the "snap" growth of single crystals. Apparently, the heterogeneous structure, which is characterized by a layered distribution of both impurities and defects, is a consequence of a mismatch of the thermal axis and the axis of the growing crystal. One of the main practical conclusions is that, despite an apparent lack of difference between one- and two-element cathodes, only a singleton cathode in the form of the loop provides satisfactory symmetry of the electron flux and temperature field. It contributes to the problem of obtaining homogeneous single crystals with the reproducible structure and crystallographic characteristics along the entire length. The basic requirements that determine conditions for the stable operation of the electronic guns and, especially, EBFZM set-ups can be formulated as follows: an absence of sputter on the filament, i.e., the filament should be in the "shadow", and the system of focusing electrodes should provide the appropriate curvilinear electron beam and focus it on the sample-anode; the design of the electron gun should ensure a prompt removal from the inter-electrode space all gases released from the sample; the gun design must give certain rigidity and total absence of warping after the prolonged exposure to high temperatures, so all the parts of the gun must be performed of a high thermal conductivity material (e.g., copper) and cooled by water; high vacuum EBFZM set-ups should be met by the tightness of the melting chamber, the pumping powerful vacuum system and reduced gas release from samples; the power supply must provide a long-term operation of the annular electron gun at given electric modes; moving both the annular electron gun and sample-anode during growing should be coaxial at the whole length of the sample [20,21]. Figure 1b shows a schematic interior of EBFZM set-up for growing crystals and bicrystals. The liquid zone 10 on the single-crystalline rod 4 is produced by the electron beam 9 emitted from the tungsten filament (cathode) 1. Focusing is carried out by the electron gun 2. The power supply provides the accelerating voltage of 25 kV and the anode current up to 1 A. The growth rate of bicrystals is 1÷1.5 mm min-1 while rotating the seed 6 at the rate 20 rev min-1. A lack of positive feedbacks between the cathode and the anode in the electron gun allows maintaining the average power of the electron beam, which is almost constant throughout the growing single crystals or bicrystals. Random power fluctuations with a frequency of several hertz do not exceed 0.1% of a nominal value.
3.2. Metallographic examinations
Metallographic examinations of the crystal structure at the macro and micro levels provide extensive qualitative and quantitative information about the structure [22-24]. A possibility exists to measure of various structural elements up to 1 micron. A range of crystallographic planes of the crystal orientation can be determined by etch pits and execute it with an accuracy of ±3÷5°. The dislocation density in the crystal can be evaluated according to the number of etch pits per unit area (in the event that it does not exceed 108 cm-2). An interference attachment to a metallographic microscope gives a possibility to evaluate the surface roughness of cross-sections. The polarization console allows detecting inclusions of the second phase in a sample, if the latter is present in significant amounts. To carry out metallographic studies the sample must first be cut off from the corresponding bulk single crystal and then prepared by grinding. Cutting samples of molybdenum and tungsten single crystals of necessary geometry and crystallographic orientations can be produced by the electroerosion device. It is well known that this technique can produce a significant damage of the sample surface - to a depth of about 300 microns. When this happens, the surface contamination and defects lead to increase of dislocations in the surface layer, but also there appear a typical network of cracks extending to a considerable depth. After cutting, all the above defects must be removed by both the mechanical grinding and polishing. Then, the cold-worked layer should be removed by chemical etching and electropolishing at the optimal conditions. However, it is necessary to keep in mind two things. First, all etchants are divided into two large groups. The first group has a pronounced orientation effect, i.e., gives well-cut pits that are useful for determining an orientation of the crystal. In general, the etching figures revealed by these etchants have nothing with the outgrowth of dislocations. The second group represent etchants to produce etch pits, revealing the outgrowing low-angle boundaries and individual dislocations. But even in this case to speak about one correspondence of etch pits and dislocation is not correct, it requires evidences in each case. With regard to detection of the microstructure of tungsten and molybdenum crystals is, for example, a commonly known Murakami etchant (10 g NaOH, 30 g of K3Fe(CN)6, 100 g of H2O) which has a strong orientation effect, although it is also identifies some low-angle boundaries. Electrochemical etching in a 5% aqueous solution H4OH gives similar results as Murakami etchant. In our view, it is more convenient to identify the substructure of the molybdenum and tungsten single crystals by an electrolytic etching in 25% NH4OH solution under the following conditions: the current density j = 5÷10 mA cm-2, the voltage U = 2÷3 V and the time τ = 60÷90 s. It turns out that the etchant "works" not only to identify dislocations, but also to reveal dislocations introduced into the crystal as a result of plastic deformation at the surface with a prick of the diamond indenter. Furthermore, this etchant identifies sub-boundaries with small misorientation angles and thus it has been widely used to detect the substructure of molybdenum and tungsten single crystals, grown from the melt by EBFZM. For metallographic studies the optical microscopes and automatic analyzer are used. The latter is widely used for the quantitative metallographic analysis of the linear substructure: the subgrain size distribution along and across the crystal, the dislocation density inside the subgrains averaged at least for 20 fields of view, and by the stereometric metallographic analysis as well. It should be noted that at identification of the subgrain structure of molybdenum and tungsten single crystals by means of the above proposed etchants, the metallographic studies are possible mainly at the planes of low crystallographic indices of the type {001} and {111} planes as well as with higher indices deviate from these planes in opposite directions at angles in the range 10÷15°.
3.3. X-ray studies
It is known that in many cases some low-angle boundaries can be qualitatively compared by misorientation angles. In other words, it is a qualitative determination, where misorientation angles of neighboring subgrains are more and where – less, because aA quantitative determination of misorientation angles by metallographic methods is impossible. To obtain such information on the real structure of the crystal it is necessary to use methods of X-ray diffraction microscopy. Here, to obtain the quantitative information about misorientation angles of the substructure elements of molybdenum and tungsten single crystals we used both the X-ray topograms of angular scanning and X-ray recording by the wide divergent beam. Especially clear for determining misorientation angles is the method of the X-ray wide divergent beam [25]. On the X-ray record of the perfect crystal, free of low-angle boundaries, Kossel lines are solid curves of the second order. In the block crystal, recording through the low-angle boundary between adjacent subgrains, the orientation changes abruptly and Kossel lines contain gaps. Both methods allow defining misorientation angles of substructure elements with a resolution of ~1 arc min, and linear dimensions of subgrains with a resolution of about 3÷5 microns. To determine the orientation of crystals and the fulfillment of their orientation in the desired crystallographic direction with an accuracy of ±1÷2° was used as the standard method of taking Laue epigrams.
3.4. Electron microscopy studies
Of serious interest is the question about what kind of dislocations occurs during growth from the melt? It rises from the standpoint of a study of physical aspects of the crystallization process. Most of disclocations are assembled into grids and walls as a result of poligonization processes and form the characteristic substructure. Such dislocation ensembles consisting of growth dislocations are also of interest. To undertake such a research on the real crystal structure the most suitable method is transmission electron microscopy, which allows determining the type of dislocations, their Burgers vectors and crystallography of low-angle boundaries. However, consider the following fact: as a rule, in molybdenum and tungsten single crystals grown from the melt by zone melting, the dislocation density inside the subgrains is of a value ρ ≥ 105 cm-2. By other words, an average distance between dislocations is X ≈ 0,003 cm ≃ 30 micron with an average size of subgrains d ≃ 500 micron. It means that the volume, occupied by actual low-angle boundaries, is negligible. This also means that in the case of preparing foils for electron microscopy of an arbitrary portion of a bulk sample, a single dislocation from a subgrain volume can be observed in one of 5÷10 samples. Observation of low-angle boundaries of such samples would require at least 10 times more samples (taking into account that a really observable surface of a sample has an area of about 5 micron2). Naturally, to prepare samples having such little hope of success is a real Sisyphean task. Therefore, a method of preparation of foils is used, which provides a hole in a specified area in vicinity of low-angle boundaries. An essence of the method is as follows. On one side of the original sample in a form of the washer of diameter 3 mm and thickness of 0.3-0.4 mm the substructure is detected using metallographic techniques. Then, on this side of the sample a protective film of a clearcoat (in the simplest case – a collodion) is applied to the surface and thoroughly dried. Next by the microhardness recorder PMT-3 using a diamond indenter the protective layer is violated in the right place (or a series of injections or scratches) and by electropolishing a recess of a required depth is received. Optionally, this set of operations might be repeated. It should only be kept in mind that in the process of the electropolishing all of dislocations should be removed from the surface layer of the sample, introduced there by the action of the indenter. Thereafter, the varnish is removed from the sample surface by using an organic solvent (acetone, ether) and the electropolishing is performed from the reverse side of the sample before the formation of holes. With the described method of the sample preparation, a likelihood that low-angle boundaries would be available for observation increases substantially - to 1/5÷1/10 (an experimental evaluation).
3.5. Chemical purity
As mentioned before, the presence of significant amounts of impurities has a significant impact on the structure and properties of the crystals, and for molybdenum and tungsten the greatest impact on the properties is made by interstitial impurities, primarily carbon, which is characterized by very low solubility limits in the solid state at room temperature [26]. Therefore, the analysis of the chemical composition and purity control of single crystals is an important part of the characterization of a material. In this work, an oxygen content is determined by fast neutron activation with a sensitivity of 5x10-5%, carbon is analyzed by deuteron-activation with a sensitivity of 10-6% [27,28]. Additionally, carbon is monitored by the coulometric method on AN-160 device with a sensitivity of 5x10-4%. To determine other impurities in single crystals and bicrystals, mass-spectrometry with a sensitivity of 10-6% is used. The content of impurities is shown in Table 1. The purity of metals is also checked by a residual resistivity at liquid-helium temperatures, since at low temperatures the main mechanism of the carriers scattering in metals is scattering on impurities [29]. Here, the ratio of resistivities at room and liquid-helium temperatures is defined by the non-contact and four-contact methods. For the single crystals studied this value is not less than (2÷3)x104.
\n\t\t
\n\t\t
\n\t\t
\n\t\t
\n\t\t
\n\t\t
\n\t\t
\n\t\t
\n\t\t
\n\t\t
\n\t\t
\n\t\t
\n\t\t
\n\t\t
\n\t\t\t
\n\t\t\t\tMetal\n\t\t\t
\n\t\t\t
\n\t\t\t\tContent of impurities, x10-4%\n\t\t\t
\n\t\t
\n\t\t
\n\t\t\t
O
\n\t\t\t
C
\n\t\t\t
N
\n\t\t\t
H
\n\t\t\t
Si
\n\t\t\t
Al
\n\t\t\t
K
\n\t\t\t
Ca
\n\t\t\t
Na
\n\t\t\t
P
\n\t\t\t
S
\n\t\t\t
Mn
\n\t\t
\n\t\t
\n\t\t\t
\n\t\t\t\tMo\n\t\t\t
\n\t\t\t
<0.5
\n\t\t\t
<0.5
\n\t\t\t
<0.6
\n\t\t\t
<1.0
\n\t\t\t
<0.3
\n\t\t\t
<0.1
\n\t\t\t
<0.1
\n\t\t\t
<0.1
\n\t\t\t
<0.1
\n\t\t\t
<0.03
\n\t\t\t
<0.1
\n\t\t\t
<0.03
\n\t\t
\n\t\t
\n\t\t\t
\n\t\t\t\tW\n\t\t\t
\n\t\t\t
<0.5
\n\t\t\t
<1.0
\n\t\t\t
<0.6
\n\t\t\t
-
\n\t\t\t
<0.3
\n\t\t\t
<0.1
\n\t\t\t
<0.1
\n\t\t\t
<0.1
\n\t\t\t
<0.3
\n\t\t\t
<0.3
\n\t\t\t
<0.3
\n\t\t\t
<0.3
\n\t\t
\n\t\n\t\t
\n\t\t\t
\n\t\t\t
Mo
\n\t\t\t
Nb
\n\t\t\t
Re
\n\t\t\t
V
\n\t\t\t
Fe
\n\t\t\t
Ni
\n\t\t\t
Co
\n\t\t\t
Ti
\n\t\t\t
Cr
\n\t\t\t
Cu
\n\t\t\t
Rb
\n\t\t\t
Zr
\n\t\t
\n\t\t
\n\t\t\t
\n\t\t\t\tMo\n\t\t\t
\n\t\t\t
-
\n\t\t\t
<1
\n\t\t\t
<0.3
\n\t\t\t
<0.1
\n\t\t\t
<0.1
\n\t\t\t
<0.03
\n\t\t\t
<0.03
\n\t\t\t
<0.03
\n\t\t\t
<0.3
\n\t\t\t
<0.03
\n\t\t\t
<0.03
\n\t\t\t
<0.1
\n\t\t
\n\t\t
\n\t\t\t
\n\t\t\t\tW\n\t\t\t
\n\t\t\t
<1
\n\t\t\t
-
\n\t\t\t
<0.1
\n\t\t\t
<0.1
\n\t\t\t
<0.3
\n\t\t\t
<0.1
\n\t\t\t
<0.03
\n\t\t\t
<0.06
\n\t\t\t
<0.3
\n\t\t\t
<0.03
\n\t\t\t
<0.05
\n\t\t\t
<0.1
\n\t\t
\n\t
Table 1.
Content of impurities in the pure molybdenum and tungsten.
4. Growing bicrystals of refractory metals
4.1. Some features of growing bicrystals
Metals and their alloys in the polycrystalline state represent a set of randomly oriented crystallites, or grains, which separated by high-angle boundaries. Properties of polycrystalline materials that are widely used conventionally in materials science and technology largely depend on the size and crystallographic orientation of the constituent grains and, consequently, on the properties of boundaries between the grains. Therefore it is not accidental that the interfacial properties of a type “solid – solid” attracted the most attention of specialists for many years. In recent years a number of theoretical and experimental studies of the interface boundary structure, the energetic and regularities of the grain boundary diffusion and high-temperature creep, the segregation of impurities and structural defects at the interface, as well as processes of heterogeneous nucleation at the interface during phase transitions, is significantly increased [29]. For an experimental investigation of the above phenomena, it is desirable to have samples with well known or readily determinable geometrical relationships between crystallites. From this point of view, of course, the interfaces in bicrystals with known crystallographic parameters are the most convenient and preferable objects. Growing methods of metal bicrystals can be divided into two main groups. The first one includes methods in which oriented bicrystals can be grown from two oriented seeds using standard methods of Chalmers, Czochralski, Bridgman or zone recrystallization. The second group includes methods in which the interphase boundary is obtained by sintering together two plates of oriented single crystals. It should be noted that both groups of methods allow receiving both twist and tilt boundaries, as well as mixed ones. Consider the specific advantages and disadvantages of both groups. There is a lot of information on getting oriented bicrystals of various metals and alloys by sintering or diffusion welding [30-48]. Using this method to obtain bicrystals usually leads to the fact that boundaries contain a substantial amount of pores and oxide inclusions. Upgraded versions of the method are used to produce bicrystals of copper, silver, nickel, copper-indium and copper-arsenic alloys. In this case, the boundary turns out fairly flat, and does not contain inclusions of the second phase; although sometimes on the boundary an emergence of a small stray of grains of arbitrary crystallographic orientations have been found. Unfortunately, this is not the only downside: sophisticated UHV equipment is necessary for sintering, and the sintering processes last for 10÷20 hours. Furthermore, disks prepared for sintering should be flat and have a surface roughness of not more than 0.1÷0.3 micron, which could be achieved by using diamond polishing pastes. It is clear that before sintering the electropolished deformed surface layer should be removed, otherwise recrystallization becomes inevitable and qualitative boundaries cannot be obtained. Bicrystals of low-melting-points metals can be grown using the method from other group. The essence is that bicrystals can be grown from the melt with the help of two correctly oriented seeds causes no problems at all. Somewhat more complicated is the situation in this way to grow bicrystals of refractory metals such as molybdenum, tungsten, niobium, tantalum, vanadium, etc. There is information on growing niobium bicrystals by arc zone melting method [40]. However, this technique does not permit to obtain the required stability of the molten zone and the symmetry of the temperature gradients in the melt and in the solid phase. This leads both to an increased density of dislocations and low quality of the grown bicrystals. The original method of growing bicrystals of niobium by electron-beam zone melting is described in [38]. The essence of this method consists in the following. The single crystalline seed of a cylindrical shape partially cut along a plane of symmetry parallel to the growth axis [110]. Next by moving apart the halves of the original single-crystal seed typed at the desired misorientation angle of the boundary of the bicrystal to grow. Then the bicrystal can be grown simultaneously from both halves of the seed. Thus, the niobium bicrystals of diameter of 6.3 mm and length of 100 mm are obtained. In our opinion, this technique of growing bicrystals, though captivating by its simplicity, but it is too "capricious", on which, however, suggest the authors themselves. They managed to get good bicrystals in only one case out of four. In our view, the failure of the following causes: a poor quality of the electron gun in heating and a complexity of the adjustment of the Y-shaped seed in the thermal zone. Another method of producing bicrystals of refractory metals is described in [30]. The essence of this simple method is as follows: on single-crystal rods the molten zone is created. Then after rotation of the base bar to the desired angle the zone is "frozen". For all its simplicity and attractiveness of this technique it is also not free from shortcomings. First, a small size of a boundary: no more than a diameter of the rod; secondly, the boundary is wavy, as it turns out not as a result of the joint growth of two neighboring grains, but as a result of the "collapse" of moving towards each other two crystallization fronts whose profile in the process of EBFZM is substantially non-planar. In our opinion, the most suitable melting technique for obtaining bicrystals of refractory metals with bcc lattice, which do not undergo phase transitions in the solid state, is only EBFZM. This technique allows obtaining a necessary stability of the molten zone and the axial temperature gradient, as well as the required symmetry of the radial temperature gradients. The latter condition is largely ensures a stability of the growth process of bicrystalline boundaries when growing simultaneously from two seeds oriented in a predetermined manner [36,39]. Stability of the growth of the grain boundary in bicrystals simultaneously from two seed crystals oriented in the predetermined manner, largely due to the symmetry and uniformity of the temperature field. Based on structural features of EBFZM set-up, we would like to note some highlights that should be considered when growing bicrystals of pure refractory metals: (1) the stability and radial uniformity of the power supplied by the electron gun; (2) the co-axiality of the growing bicrystal and electron gun (coincidence of thermal and geometric axes or centers in the liquid zone); (3) the uniformity of the heat removal from the growing bicrystal through the elements of the seed and bicrystal. An important advantage of this method is the possibility of growing bicrystals of up to 150÷200 mm long and up to 15÷25 mm in diameter, suitable for investigating properties of the bicrystalline boundaries both parallel and perpendicular to the growth axis in a large number of reproducible samples. Experiments are carried out on growing bicrystals without rotation, but it turned out that this may affect even minor violations of the local temperature profile in the liquid zone, resulting in one of the growing crystals in the bicrystal can die out. For the manufacture of seeds of 10÷25 mm in diameter and 15÷20 mm in length, consisting of two halves with different single-crystal orientations, the cylindrical single crystals of certain crystallographic directions are used. A deviation from the certain crystallographic direction does not exceed 1÷2°. At first, to prepare the parts for the seeds the initial single crystal should be cut by the electroerosion into cylinders of 20 mm long (Figure 2). The cylinders are cut by the diametrical plane to segments for the purpose of obtaining the desired misorientation angle.
Figure 2.
Schemes of preparation of bicrystalline seeds.
The segments of the bicrystalline seed are chemically etched in a mixture of hydrofluoric and nitric acids. Bicrystalline seeds are produced by combining the single-crystalline segments (e.g., 1a+2b or 1b+2a) prepared by the method described above. Another method of preparing the seeds is that one of the segments further cut at an angle equal to the misorientation angle of the bicrystal to grow. This method proved to be a little bit easier, because it does not require additional operations of the orientation of single crystals. In cases where, besides the misorientation angle, the defined crystallographic parameters should also have the bedding plane of the grain boundary, the plane is defined with respect to which the boundary should be symmetrical. Then a cut is made along a plane that is separated from it by an angle equal to half of the misorientation angle of the bicrystal to grow. The resulting combined two single-crystalline segments after rotation of one of them in the cutting plane by 180° around the axis perpendicular to this plane. Later the plane of the contact between two segments of the bicrystalline seed should be the grain boundary of the growing bicrystal. In the process of the zone growing the grain boundary remains strictly specified and parallel to the axis of the bicrystal and to the axes of both single-crystalline halves of the seed. Our experience has shown that these procedures of preparing bicrystalline seeds are the most important and sufficient for the reproducible growth of bicrystals with any misorientation angle. The method allows growing bicrystals of niobium and molybdenum with the misorientation angles from 5 to 55°. Bicrystals are of 30 mm in diameter and of 100-150 mm long (Figure 3). A correct preparation of bicrystalline seeds and a compliance of the optimal temperature distribution allow avoiding pinching one grain by another. The visual and metallographic examinations of bicrystalline samples show that the grain boundaries are macroscopically flat over large areas and do not contain "parasitic" grains or the second phase inclusions. Transverse sections of niobium bicrystals are examined by the optical and scanning electron microscopes, after the mechanical and chemical polishing treatment of the samples in the heated until 50÷70°C solution of a mixture of hydrofluoric and nitric acids. Then, the grain boundaries are detected by etching in the same solution at 20°C.
Figure 3.
Mo bicrystal of 16 mm in dia (a) and bicrystalline boundary on cross-section (b).
4.2. Studies of strength of high-angle boundaries in molybdenum bicrystals
Tendency of undoped refractory metals of Group 6 (molybdenum, tungsten) to intergranular embrittleness do not only create difficulties in processing, but also significantly reduce the scope of their practical use [32]. Because of complexity of grain boundaries in polycrystalline samples, containing a large and, to some extent, uncontrollable set of grains, studies are carried out on specially prepared bicrystals with well-known crystallographic parameters, because they are the most convenient model objects for the grain boundaries studies. In [30,32,36,49], the dependence of the strength of grain boundaries in molybdenum bicrystals is revealed on the type of boundaries and the misorientation angle between the grains. By the 3-points bend test (Figure 4) it is established that the high-angle boundaries (over 7÷10°) less strong in comparison to low-angle boundaries, and that the higher strength the closer to the boundary planes (100) or (110). It is proved that the twist boundaries in the molybdenum bicrystals are more brittle compared to the tilt ones [41,42]. True, in both types of boundaries (twist and tilt) the possible influence of the bedding plane of the grain boundaries is not taken into account. It should be noted that in the polycrystalline ingots of molybdenum are usually found all types of boundaries and the misorientation angles in different sections of the ingots vary widely. The main reason for the different behavior of the high- and low-angle grain boundaries is the nature of the interaction of these boundaries with impurity atoms. Low-angle boundaries with misorientation angles up to 7÷10°, as a rule, consist of lattice dislocations. In the boundaries of high-angle (over 10÷15°) the distance between dislocations is so small that their nuclei combine, causing to have different atomic structures. Apparently, impurity atoms by a reaction with the low-angle boundaries are located on their constituent dislocations, whereby the low-angle boundaries occur at areas with a reduced content of impurities. At the high-angle boundaries the impurities segregate more evenly along the boundary, strongly weakening a grip of grains. Therefore, there is an increased susceptibility to intergranular embrittlement. The embrittlement of cast or recrystallized molybdenum largely depends on the interstitial impurities (carbon, oxygen, nitrogen), which, due to the low solubility in the crystal lattice, are allocated along the grain boundaries [41-46]. It was qualitatively shown that at the carbon content of less than 10-3% the strength of bicrystalline boundaries depends on their structure, and above this content - the strength of the bicrystalline boundaries is the same and does not depend on the carbon content. However, it remains unclear why there is the "critical" content, the more that the solubility of carbon and oxygen in molybdenum is by several orders of magnitude lower. Also unclear is the question, what is the relationship between the total content of interstitial impurities in molybdenum and the content of second phase (carbides, oxides) at the grain boundaries. Using the molybdenum bicrystals in studies of grain boundaries usually encounter with serious difficulties in getting bicrystals of given crystallographic parameters, as well in preparing a sufficiently large number of reproducible bicrystalline samples from the same bicrystal.
Figure 4.
points bend test of bicrystals.
Apparently, one of the essential crystallographic parameters of the samples is the bedding plane of the grain boundaries, which are still obtained by chance, since the known methods do not allow to grow the molybdenum bicrystals with any desired plane boundary. In the bicrystalline twist boundaries the axis of twist uniquely determines the plane of the grain boundary. The widest range of the bedding planes of the grain boundaries can be obtained at bicrystals with the tilt boundaries when at one axis in the case of the symmetrical boundaries can exist two bedding planes and in the case of asymmetric boundaries - of any number. In [36,46], the strength of the bicrystalline twist and tilt boundaries in molybdenum bicrystals is studied depending on the misorientation angle between two grains and on the bedding plane of the grain boundary (i.e., the boundaries with a different number of coincident nodes Σ). In [46], the molybdenum bicrystals are grown by the method, the main feature of which is the existence of the optimal temperature distribution in the liquid zone. The samples with twist boundaries are prepared as described in [47,48], but for the growth the better electron gun is used, which allows to create the very narrow liquid zone on the sample and, consequently, more even grain boundaries. In the grown bicrystals the symmetric tilt boundary [100] lies along the plane (120), and the twist boundary - along (100). The bicrystals with the tilt boundaries [100] have misorientation angles and bedding plane other than special boundaries (σ = 36.5°) with a number of matching nodes Σ = 5. The bicrystals with the twist boundaries also differ by the misorientation angle of the special twist boundary (σ = 36.5°) with Σ = 5. Also, the bicrystals with the tilt boundaries [110] are grown, which are intended for similar studies. In particular, bicrystals are prepared with tilt twin boundaries [110] and the misorientation angle of 70° between the grains and the bedding plane of the boundaries (112) and (111); for comparison it is grown the bicrystal with the misorientation angle of 64° and the plane of the grain boundary, deviated from the (111) plane for 3°. The initial single-crystalline rods, from which the bicrystals are then grown, are prepared in two ways. First, the molybdenum bicrystals (Mo-1) are of a standard purity (see\n\t\t\t\t\tTable 2). Secondly, for comparison, the molybdenum bicrystals (Mo-II) of highly-pure molybdenum are grown.
\n\t\t
\n\t\t
\n\t\t
\n\t\t
\n\t\t
\n\t\t
\n\t\t
\n\t\t
\n\t\t
\n\t\t\t
\n\t\t\t\tSamples\n\t\t\t
\n\t\t\t
\n\t\t\t\tImpurity content, х10-3%\n\t\t\t
\n\t\t\t
\n\t\t\t\tMetallic impurities\n\t\t\t
\n\t\t\t
\n\t\t\t\tResidual resistivity ratio (RRR) R273K/R4,2K\n\t\t\t\t\n\t\t\t
\n\t\t
\n\t\t
\n\t\t\t
О
\n\t\t\t
С
\n\t\t\t
N
\n\t\t\t
H
\n\t\t\t
W
\n\t\t
\n\t\t
\n\t\t\t
\n\t\t\t\tI\n\t\t\t
\n\t\t\t
<0.1
\n\t\t\t
<1
\n\t\t\t
<0.4
\n\t\t\t
<0.1
\n\t\t\t
<3
\n\t\t\t
<1
\n\t\t\t
1500
\n\t\t
\n\t\t
\n\t\t\t
\n\t\t\t\tII\n\t\t\t
\n\t\t\t
<0.1
\n\t\t\t
<0.01
\n\t\t\t
<0.02
\n\t\t\t
<0.1
\n\t\t\t
<0.3
\n\t\t\t
<0.1
\n\t\t\t
30000
\n\t\t
\n\t
Table 2.
Impurity contents and residual resistivity of molybdenum (two levels of purity).
Bicrystalline samples are tested for strength by the three-point bend device (the rate of deformation 0.01-0.1 mm.min-1). The distance between supports is 9 mm, the radius of supports and the knife - 1 mm. For testing of each bicrystal, 3÷5 bars of the size 1,5x2x16 mm are prepared. The bending axis in bars lies in the plane of the grain boundary and is perpendicular to the common axis of the bicrystal. Tests are conducted at room temperature, and then the fracture stress is calculated by loading curves. The yield criterion is the stress at which plastic deformation is of 0.2%. The dependence of the fracture stress on the misorientation angle of the special (36.5°) tilt and twist [100] boundaries is shown in Figure 5. Topography of fracture surfaces is examined in the scanning electron microscope JSM-T35 at the accelerating voltage of 25-35 kV. Auger spectra of the surfaces of fractured grain boundaries are recorded on the Auger spectrometer РНI-551 with the base residual pressure in the chamber, not exceeding 1x10-7 Pa. "Fresh" surfaces of the grain boundary fracture are obtained in the pre-chamber of the Auger spectrometer at vacuum of 1x10-5 Pa. The spectrum recording time - no more than 1 min, the focal spot diameter - 10-5 m. Grain boundaries are revealed by etching in the mixture of nitric and sulfuric acids. For the X-ray diffraction study of the grain boundaries, the bicrystalline samples are mechanically polished and electropolished in a concentrated sulfuric acid. Laue patterns are obtained from individual grains with an accuracy of 1÷2°. The tests have shown that almost all bicrystals have the brittle fracture, although on some of them plots of plastic deformation before fracture are observed (Table 3). The fracture of specimens under the applied load passes strictly along the grain boundary. The study by the optical microscope reveals that all samples have the flat boundary parallel to the axis of the bicrystal. Without plastic deformation, the fracture stress perpendicular to the grain boundary is calculated from the load to fracture, considering the sample as the elastic bar.
Figure 5.
Fracture stress vs. misorientation angle.
Strength does not exceed the fracture stress of the boundaries on the cleavage plane (100) and depends both on the misorientation angle between the grains and on the bedding plane of the grain boundary at the same misorientation angle between grains. The significant stress of the fracture equal 30x107 N m-2 is observed on the sample Nr 13 with the boundary of a general type; the fracture takes place with appreciable plastic deformation (up to 7%). The fracture stress equal 25x107 N m-2 is obtained on the sample Nr 11 with the twin tilt boundary lying in the incoherent twinning plane (112). This bicrystal has an elongation approximately 1%. The stress fracture of the sample Nr 12 with the twin boundary and the bedding plane along the coherent twin plane (111) is 11x107 N m-2. On the sample Nr 10 with the misorientation angle of 640 the fracture stress is equal 15x107 N m-2. The molybdenum bicrystals with the special tilt and twist [100] grain boundaries are fractured at low loads and often uncontrollable, although the boundaries other than special, it turns out, tend to be of the much higher strength. The strength of the tilt boundaries [100] with the misorientation angle of 33° reach relatively high values - 55x107 N m-2, although at other angles the strength is low (below 10x107 N m-2). The twist boundaries [100] at the misorientation angles of 34÷350 and 400 are quite strong - (25÷30)x107 N m-2, but at 28° the strength decreases to 10x107 N m-2. It is seen in Figure 5 that in the special boundary minimum of the strength is observed for twist and tilt boundaries in the region adjacent to the angle of 36.5°. To test the effect of the bedding plane of the grain boundary on its strength the bicrystal is grown. It contains the misorientation angle 33° and the bedding plane deviated by 45° from the plane of the boundary in the bicrystals with the greatest strength, equal 55x107 N m-2. The tests have shown that the strength of such boundary is almost five times lower. According to [45], the orientation dependence of the strength of the grain boundaries is of the monotonous character and the strength of the tilt and twist boundaries in the range of angles from 20 to 45°, as a rule, does not exceed (8÷10)×107 N m-2. The slight deviation from the monotony is found for the twin tilt boundaries [100]. In [44], extremes are found on the orientation dependence of the tilt boundaries [110] with the misorientation angles of approximately 100 and 55°, but absolute values of the fracture stress for the boundaries of both types are too high – up to (100÷150)x107 N m-2, i.e., even exceed the tensile strength of the molybdenum single crystals and, apparently, is incorrect. Kinks on the twist boundaries are shown in Figure 6. It is clearly visible chains of the second phase precipitates (presumably, carbides) at the terraced kinks and precipitates like needles at right angles to each other.
Figure 6.
Fractography of the fracture surface of the twist [100] grain boundary (a) and of the tilt twin boundary [110] (b).
Crystallographic and strength characteristics of samples with the tilt and twist boundaries [110] and [100].
*bicrystals grown from Мо-II.
It should be noted that on the fractures of the twist bicrystalline boundaries of Mo-II the significantly smaller amount of the second phase is present, in comparison to samples from Mo-I. The molybdenum bicrystals with special twist boundaries, however, are fractured with the uncontrolled stress, although the precipitates at the fractured boundaries are virtually absent. The small precipitates in a form of thin films on fractured surfaces of the special tilt boundaries are observed; however, they disappear when exposed to the electron beam. Analysis of Auger spectra from different areas of the fracture surface of tilt boundaries [110] has shown that the intensity of Auger peaks of carbon, oxygen and nitrogen is varied. Near the outer surface there is the extended zone of a width 0.1÷0.2 mm, in which the oxygen content is 20% higher in comparison with central areas. On peripheral areas there is also the high nitrogen content; however, at central areas at the grain boundary the intensity of Auger lines is close to zero. The intensity of Auger lines of carbon, conversely, is increased from the periphery to the center. These data, of course, are qualitative in nature, as in the pre-chamber of the Auger spectrometer the residual pressure is such that the number of atoms colliding with the surface for one second corresponds to one atomic layer, while the process of transferring the sample in the chamber of the Auger spectrometer takes about 10 minutes. The Auger spectrum of the fracture surface of the sample Nr 7 shows that it contains lines, except the molybdenum line, of carbon (272 eV) and oxygen (503 eV). The low intensity line (380 eV) is, apparently, due to nitrogen. A peak of oxygen should be partially attributed to the adsorption of oxygen from the residual gas in the pre-chamber. A form of the Auger carbon line reveals that it is partially caused by adsorbed hydrocarbons, and partially - by a presence in the analysis zone of molybdenum carbide, as evidenced by the low-energy characteristic of the comb structure of lines. It is unlikely that in the presence of the significant amount of dissociated oxygen the surface carbide formed immediately after destruction of the sample along the bicrystalline boundary. Most likely, the Auger spectrum has elicited the three-dimensional carbide precipitates that already exist on the grain boundary. After the ion etching of the fracture surface at the grain boundary the contents of elements in the area of the analysis have been varied somewhat. The intensities of Auger lines during the etching of the sample Nr 7 show that at transition to deeper layers carbon and oxygen decrease as compared with the "fresh" fracture surface.
The shape of the Auger line of carbon during etching also varies considerably and becomes fully "carbide-like". Due to the lower sputter coefficient of carbon compared with the sputter coefficient of molybdenum, the carbon accumulation can occur near the surface. The absolute value of the ratio C/Mo determined from the Auger spectra after the prolonged etching is substantially overstated. To correct the carbon content profile in view of this accumulation is not yet possible; however, given in Table 4, the values of C/Mo permit make a comparison between the samples by the volume content of carbon, so long as at the prolonged etching the enrichment of carbon should be proportional to the volume content of carbon. Oxygen distribution is the same for all bicrystalline samples, although in the course of ion etching the intensity of the Auger line of oxygen falls. The region, rich of oxygen, is no more than 80 Å. The character of distribution with the depth is different for all the samples, but the intensity of the Auger line falls with the depth. On some specimens the marked intensity of the Auger lines persists to a depth of 800÷6000 Å. The maximum intensity of the Auger line of molybdenum is in the range 20÷50 Å. It is because the early etching removes contaminated layers in which the content of molybdenum is relatively lower than in the matrix. In the course of etching the analyzed surface roughness caused by uneven etching of its various portions is enhanced, which leads to additional scattering of the Auger electrons. Because of low solubility of interstitial impurities in molybdenum at cooling rates typical for growing molybdenum bicrystals they are allocated as the second phase. While it is not possible to correctly assess the degree of enrichment of the grain boundaries with the interstitial impurities or precipitates. It can only be based on comparison of the relative content of interstitials on the tilt and twist boundaries. At the "fresh" fracture surface and at the depth of up to 1000 Å from the surface, it is possible to argue that the degrees of "contamination" of the boundaries of both types are identical. Secondly, it can be concluded that most of the carbon on the fracture surface is bound to carbide precipitates.
Ratio of chemical elements on the surface of the grain boundaries and at the depth of up to 1000 Å from the surface of the tilt and twist grain boundaries [100].
Of particular interest is comparison of bicrystals with the different initial purity. Although the content of interstitials in Mo-II is much lower even in comparison with pure Mo-I, the boundary strength of the tilt bicrystals, grown from Mo-II, differ a little from the strength of the samples of Mo-I. This is all the more surprising that, according to the Auger analysis at grain boundaries of samples grown from Mo-I, as the carbon content on the fracture surface, and in the depth of grains is substantially higher. The oxygen content is the same at boundaries of all samples. In [43,45], argued that the fracture stress of twist boundaries is inversely to the oxygen content on boundaries, and the role of carbon was reduced mainly to suppress this effect. Experimental results obtained so far are not enough to talk about any influence of oxygen on the strength of grain boundaries. The boundary strength of pure molybdenum, which conducted the present study on, is primarily dependent on high misorientation angles of boundaries, and change of the total content of interstitials in the investigated content range does not lead to any noticeable change in strength.
4.3. Studies of fine structure of low-angle boundaries in tungsten bicrystals
In bcc metals is most likely the presence of dislocations with Burgers vectors of a/2[111] and a[100], where, a is the period of a cubic lattice [23,41,48]. However, there is no information about the presence of dislocations with Burgers vector a[110] in the bcc metal crystals. Low-angle boundaries and the characteristic dislocation substructure, particularly of tungsten, are formed from these dislocations arising during the crystal growth (probably due to high thermal stresses). There is tendency to form low-angle boundaries of tilt or twist at the relatively low dislocation density in the crystal (~105÷106 cm-2) [48]. Such boundaries may consist of one (for tilt boundaries - symmetric), two, three or more families of dislocations. The fine structure of such boundaries has been comprehensively investigated in [22,23] on single crystals of tungsten and molybdenum exposed to the high-temperature creep. An average size of subgrains in such crystals is several microns. Low angle boundaries have the misorientation angle in the area 2÷4°, but consisted mainly of dislocations introduced in the crystal by means of plastic deformation instead of so-called dislocation growth. It should be noted that the dislocation model of low-angle boundaries is well established. Systems of dislocations forming low-angle boundaries are in the metal lattice and tend to have the lowest energy in crystallographic planes being located close to crystallographic planes of low indices. In particular, for the bcc lattice symmetrical tilt boundaries consisting of parallel edge dislocations, are most likely in planes {111} and {100}, asymmetric tilt boundaries - in planes of {hko}, and net twist boundaries - in planes of {110}. Thus, if to the system of dislocations, created in the flat layer of the low-angle misorientation, provide the opportunity to move (by glide and climb of), the system of low-angle boundaries should strive for the finite number of planar nets. All of the above indicates that the triple junctions of low-angle boundaries do not necessarily have to be of 120-degree. In some cases, low-angle boundaries are observed on facets on the microscale, what also appear crystallographic structural features of low-angle boundaries. It is known that the crystal grown from the seed inherits its substructure. The seed already contains stable low-angle boundaries which germinate in the growing crystal. If the bedding plane of boundaries is parallel to the crystal growth axis, such low-angle boundaries remain in the crystal and germinate over long distances, for example, in the axis and having the misorientation angle up to 1÷2°. Using the method of stereometric metallography we found that the bedding plane of the sub-boundaries with an accuracy of 1÷20 corresponds to crystallographic planes of the type {100} (Figure 7a). Low-angle boundaries are identified by etching on the plane of the single crystal W(010) with the growth axis [001].
Figure 7.
Low-angle boundaries: on (010) plane, growth axis W[001] (a), and on (100) plane along W[100], the stereometric metallography (b).
On Figure 7b metallographic cross-sections presented with a plane parallel to the axis of the crystal growth [001] correspond to the plane (010) and contains the step with a height of about 300 microns, which is greater than the depth of the focus of the microscope objective and the top of the stairs because blurred. However, it is seen that the sub-boundary located in the center is in the {100} plane. Earlier, similar results were obtained in [50] by X-ray topography. It would certainly be interesting to investigate the fine structure of such small-angle boundaries, i.e., decipher Burgers vectors of constituent dislocations, but, unfortunately, to prepare suitable electron microscopic samples is not yet possible. In principle, it is possible to create the low-angle twist or tilt misorientation in any crystallographic plane parallel to the crystal growth axis by the preparation of bicrystals. However, if in this plane cannot be obtained the artificially created misorientation by using the known complete lattice of dislocations, such low-angle boundaries cannot exist and should be quickly tapered off the crystal during the growth. Several tungsten bicrystals containing low-angle tilt or twist boundaries are grown. The characteristics of these boundaries and results of their growth are given in Table 5. For example, the pure twist boundary in the plane {110} is possible and it grows into the crystal, but the symmetric tilt boundary – no, and, naturally, it tapers off in the growing process, which shown in Figure 8.
Figure 8.
Symmetrical low-angle twist boundary (a), occurs in the {110} plane and grows in the crystal with the growth axis [110] and the low-angle tilt boundary (b) created artificially in the {110} plane, which tapers off the crystal.
The dislocation structure of low-angle boundaries in the tungsten single crystal is presented in electron micrographs (Figure 9a). On Figure 9b, the corresponding electron diffraction pattern of the area containing low-angle boundaries is shown. The foil plane corresponds approximately to the {111} plane. Having completed a flat grid of a reciprocal lattice (Figure 9c), it can be shown that the trace of the plane crossing the low-angle boundary and the foil plane is the direction l→= [45-1]. Unfortunately, the sample was too thick and the determination of Burgers vector of dislocations forming the sub-boundary, in contrast attenuation condition g→b→ = 0, is failed.
Figure 9.
Electron micrograph (a), electron diffraction pattern (b) & flat grid of a reciprocal lattice reconstructed (c) of the small-angle twist boundary in W bicrystal.
\n\t\t
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\n\t\t
\n\t\t
\n\t\t
\n\t\t
\n\t\t\t
\n\t\t\t\tSample\n\t\t\t
\n\t\t\t
\n\t\t\t\tGrowth axis\n\t\t\t
\n\t\t\t
\n\t\t\t\tBedding plane of boundary\n\t\t\t
\n\t\t\t
\n\t\t\t\tBoundary type\n\t\t\t
\n\t\t\t
\n\t\t\t\tResults of the growth\n\t\t\t
\n\t\t
\n\t\t
\n\t\t\t
\n\t\t\t\t1\n\t\t\t
\n\t\t\t
[100]
\n\t\t\t
{110}
\n\t\t\t
Tilt
\n\t\t\t
Taper off
\n\t\t
\n\t\t
\n\t\t\t
\n\t\t\t\t2\n\t\t\t
\n\t\t\t
[100]
\n\t\t\t
{110}
\n\t\t\t
Twist
\n\t\t\t
Grows in crystal
\n\t\t
\n\t\t
\n\t\t\t
\n\t\t\t\t3\n\t\t\t
\n\t\t\t
[100]
\n\t\t\t
{100}
\n\t\t\t
Tilt
\n\t\t\t
Grows in crystal
\n\t\t
\n\t\t
\n\t\t\t
\n\t\t\t\t4\n\t\t\t
\n\t\t\t
[100]
\n\t\t\t
{100}
\n\t\t\t
Twist
\n\t\t\t
Grows in crystal
\n\t\t
\n\t\t
\n\t\t\t
\n\t\t\t\t5\n\t\t\t
\n\t\t\t
[110]
\n\t\t\t
{110}
\n\t\t\t
Tilt
\n\t\t\t
Taper off
\n\t\t
\n\t\t
\n\t\t\t
\n\t\t\t\t6\n\t\t\t
\n\t\t\t
[110]
\n\t\t\t
{110}
\n\t\t\t
Twist
\n\t\t\t
Grows in crystal
\n\t\t
\n\t\t
\n\t\t\t
\n\t\t\t\t7\n\t\t\t
\n\t\t\t
[110]
\n\t\t\t
{100}
\n\t\t\t
Tilt
\n\t\t\t
Grows in crystal
\n\t\t
\n\t\t
\n\t\t\t
\n\t\t\t\t8\n\t\t\t
\n\t\t\t
[110]
\n\t\t\t
{100}
\n\t\t\t
Twist
\n\t\t\t
Taper off
\n\t\t
\n\t\t
\n\t\t\t
\n\t\t\t\t9\n\t\t\t
\n\t\t\t
[110]
\n\t\t\t
{111}
\n\t\t\t
Tilt
\n\t\t\t
Grows in crystal
\n\t\t
\n\t\t
\n\t\t\t
\n\t\t\t\t10\n\t\t\t
\n\t\t\t
[110]
\n\t\t\t
{111}
\n\t\t\t
Twist
\n\t\t\t
Grows in crystal
\n\t\t
\n\t\t
\n\t\t\t
\n\t\t\t\tMisorientation angle of low-angle boundaries always in range from 10 to 30\n\t\t\t\t\n\t\t\t
\n\t\t
\n\t
Table 5.
Crystallographic parameters of the tungsten bicrystals with the low-angle boundaries.
However, the available information, in particular about the angle γ=Lϑ→,l→, leads to the conclusion that the presented sub-boundary is the twist low-angle boundary and consists of two families of screw dislocations with Burgers vector (b→||ϑ→)b→= a/2[111]. The low-angle boundary plane is n = (134), and the corresponding Burgers vectors of screw dislocations are b→1 = a/2 [11-1] and b→2 = a/2 [1-11]. The structure of the boundary is different on different sites. It is possible to find a site of the low-angle boundary, in which dislocations of one of the families are placed non-equidistantly, but at intervals 3-4-3-4. Thus, the specific dislocation structure of low-angle boundaries formed by growth dislocations can be very difficult to reveal.
4.4. Studies of molybdenum biсrystals by low-energy ion scattering
Bicrystals, consisting of two differently oriented grains of high structural quality and purity, and grain boundary plane are the excellent models for experimental studies of various physical properties of both the surface and the grain boundary [37,51-55]. Here, the dignity of bicrystals in the studies of surface and bulk processes is shown for segregation, atomic reconstruction and self-diffusion on different crystallographic surfaces. Specifically targeted surfaces of the molybdenum bicrystals presented preselected surfaces of two grains (single crystals) and an interface therebetween. In this case both the grains are grown in exactly the same conditions, and processing of both grain surfaces is carried out in fully identical conditions. The specimens are cut of the massive molybdenum bicrystals normally to their axes, so the bicrystalline boundary is always at the centre of the flat specimens. The specimens are studied by low-energy ion scattering (LEIS). This method has a very high surface sensitivity and allows studying selectively processes taking place in the uppermost atomic layer. The LEIS signal intensity is directly proportional to the density of atoms on the surface and, therefore, must be different for differently oriented surfaces. Until recently, the LEIS technique is used for detailed studies of the surface structure of single crystals and various adsorbents on it by the angular dependence of the LEIS signal. However, the dependence of the scattering intensity of the ions from the atomic density is not obvious, experimental studies of this relationship are still not enough. Unfortunately, almost no studies that compare the LEIS signal intensities for differently oriented surfaces of the same object. The only study was done on silicon many years before where LEIS signals from the Si (111), Si (110) and Si (100) are compared. However, the ion doses used at that early time were so high that they cause severe destruction of the surface. Most likely, the correlation is discovered by accident. Now, we are able to identify and compare atomic densities on the surfaces of different low indexes single crystals and bicrystals of molybdenum and tungsten.
Figure 10.
Scheme of the LEIS experiment.
A clearer understanding of the crystallographic dependence of the signals is very important for the quantitative analysis by LEIS. For example, in the case of single-crystalline surfaces and adsorbents, this method allows getting detailed information about the atomic structure. The advantage of LEIS - an opportunity to get a statistically average result, since the scanning ion beam has a permanent, fixed diameter (from about 10 microns to about 1 mm). In the case of non-homogeneous samples scanning is possible perhaps even on an area of 1 cm2. Problems arising in the study of the crystallographic dependence of the LEIS signal, may partly explain the lack of experimental evidence; however, this relationship can only be measured on clean and well-oriented surfaces. Moreover, for comparison of two different crystallographic planes it is indispensable the preparation of the specimens in absolutely identical conditions. These problems can be successfully solved by using bicrystals. In conducting the present study were prepared surfaces of molybdenum bicrystals Mo(110) and Mo(100). These planes have been chosen due to differences in the density of atoms on the surface. Thus, Mo(110) is a close-packed surface with the higher density of atoms in bcc structure, and Mo(100) - an "open" surface with the lower density of atoms. Both surface planes are the perfect single crystals with crystallographic orientations of Mo[110] and Mo[100]. The bicrystalline boundary separating two single crystals in the center of the sample, held on {100} plane, is macroscopically smooth over the entire sample and does not contain "parasitic" inclusions of other phases. For the LEIS study, the "Mini-Mobis" with a base pressure of 2x10-10 mbar is used. The unit is equipped with measuring devices for LEIS, Auger electron spectroscopy (AES) and low-energy electron diffraction (LEED). When measuring by LEIS, the monoenergetic beams of Ne+ ions and 4He+ ions with energy of 3 keV are used. The beams bombard the sample in direction perpendicular to the surface of the sample. The ions, scattered at an angle of 1360, are detected by the analyzer of the "cylindrical mirror” type. This analyzer is used also for Auger measurements. To avoid structural defects on the surface of the sample during the experiment the ion doses do not exceed 1014 ion cm-2. The diameter of ion beam is about 400 microns, since for some LEIS intensity measurements in the boundary region between two grains (crystals), the diameter of the beam is too large, so a part of experiments are conducted on a similar LEIS set-up in which could be used the ion beam of the diameter up to 25 micron. It is comparable to the thickness of the grain boundaries in the bicrystals under study. Heating of the samples is carried out in situ by means of special cathodes consisting of a heating element and a source of electrons. Between the sample and the cathode an accelerating voltage is applied. As a result, electrons bombard the surface of the sample, causing thereby its rapid heating to temperatures of approximately 2500°C. For the present study there are grown two different molybdenum bicrystals by electron-beam floating zone melting. One bicrystal contains two grains (crystals) Mo[110] separated by a tilt boundary with a misorientation angle of 70° between grains (crystals). Another bicrystal contains grains (crystals) Mo[100] and Mo[110] separated by a 45-degree twist boundary. Both molybdenum bicrystals of 15 mm in dia are cut into the plates of 7.5x7.5x1 mm3. Thereafter, the plates are subjected to the mechanical and electrolytic polishing, followed by annealing in an oxygen atmosphere. The study of bicrystalline samples by LEIS is carried out after the final cleaning the surface in situ by the electron gun with a rapid heating to 2500°C directly in the measuring chamber. To reduce contamination of the samples in the measuring chamber, near-by elements of chamber are made of the massive high-purity molybdenum. Experiments are performed on atomically clean surfaces that are monitored by LEIS, AES and LEED. The residual contents of carbon and oxygen are below the sensitivity of LEIS (<0.1% of the monolayer using 4He+ ions with energy of 3 keV). With LEED could be seen a clear picture of the crystallographic planes (110) and (100), corresponding to two grains (crystals) of the molybdenum bicrystals. After long exposure of the specimens in the measuring chamber even in UHV, an intensity of the LEIS signal dropped, apparently due to adsorption of atoms of the residual gases present in the chamber. After repeating short heating, the sample surface becomes clean again. The quadrupole mass-spectrometer, mounted in the measuring chamber, shows that the main impurity in the annealing chamber during the sample annealing - the elements of masses 2 and 28, which correspond to nitrogen and hydrogen (or carbon monoxide), respectively. At the beginning of the experiment the surface of both grains (crystals) Mo(111) and Mo(100) are at the same level of the sample (by height). However, after "vacuum oxy-polishing" of the molybdenum bicrystal, both grains (crystals) are at different levels depending on their crystallography, and the boundary groove appeared after vacuum etching (Figure 11), the slope of the sides of which also depends on the crystallographic orientation of the grains (crystals) constituting the bicrystal.
Figure 11.
SEM micrograph of a Mo bicrystal, top view (a), and graphic profile (b) of the bicrystal boundary.
Experiments are carried out by scanning the surface of the bicrystal by a narrow beam of Ne+ ions with the diameter of 25 microns and energy of 3 keV. The measured elastic peak of the molybdenum intensity is a function of the ion beam position on the surface of the bicrystal. The studies of the bicrystal, in which both grains (crystals) are of the similar surface orientation Mo(110) and the tilt boundary, do not reveal any difference in the signal intensity between two grains (crystals). This shows that the crystallographic orientation of the surface plane itself has no effect on the value of the LEIS signal intensity, so the greatest interest is the molybdenum bicrystal with different orientations of the two grains (crystals). Interestingly, the heat treatments result in difference of segregation of carbon at different crystallographic surfaces. After the prolonged anneal of the bicrystalline sample in UHV (1 hour at 1100°C), carbon segregation from the volume on the surface Mo(100) has been detected (Fig. 12a). Naturally, at the initial state the molybdenum bicrystal has the same carbon concentration in both the grains (crystals). The volume carbon concentration does not depend on the crystallographic orientation of both surfaces of the grains (crystals). In addition, on the surface of the grain Mo(100) the carbon atoms in the initial state are not fixed at all. Carbon occurred as a result of the annealing the surface (100) is then removed by in situ annealing in an oxygen atmosphere (~10-6 Pa) at about 1500°C. However, after the prolonged anneal at about 1100°C it again appears on the surface Mo(100). In the study of the crystallographic dependence of the LEIS intensity, the signal of molybdenum is normalized to the most densely packed plane (110). It has been established (Figure 12b) that there is a clear dependence of the LEIS signal intensity from the crystallographic orientation of each grain (crystal). The presence of the grain boundary between the different planes is marked by a sharp change of the signal in position 0. The ratio R of the signal from the surface Mo(100) to the signal from the Mo(110) is found to be 0.74 ± 0.02, which is slightly higher than the ratio of the atomic densities for these crystallographic planes (0.707). As shown in [6,8], for the close-packed crystal surfaces of tungsten and rhodium, contributions to the LEIS signal intensity from the second and third atomic layers are negligible. This means that for these surfaces the signal intensity is proportional to the surface density of atoms at the uppermost atomic layer. Since we found almost exact ratio of the signals from the surfaces of Mo(110) and Mo(100), this suggests that even for an "open" plane (100) the contribution from the second and third layers to the elastic peak is negligible. To study the effect of ion bombardment on the LEIS signal, the Mo(110)/Mo(100) bicrystal is subjected to ion sputtering by the defocused ion Ne+ beam with energy of 3 keV at room temperature. The ion dose is in the range from 7x1015 ion cm-2 to 40x1015 ion cm-2 at a constant ion current 6x10-12 ion cm-2 s-1. After ion bombardment, a repeated measurement is done of the same surfaces of the sample as before sputtering (Figure 12b). The measured scan shows that after ion bombardment there is the significantly decreased signal intensity, especially for the molybdenum surface Mo(110), where the signal is decreased by 25%, whereas for molybdenum surface Mo(100) - only by 10% (see\n\t\t\t\t\tTable 6).
Figure 12.
Spectra: C segregation on Mo(110)/(100) faces (a) and recovery of LEIS yield on Mo(110)/(100) faces (b).
Sputtering increases the surface roughness. This effect can be understood if we consider the sputtered atoms from the surface Mo(110). At first glance, in this situation, for the incident ion it is easier to penetrate into the second atomic layer and not to be neutralized in the first atomic layer. Yet it is unlikely that ions could be reflected in the opposite direction and go back through the top atomic layer, remaining ionized. This situation is indeed confirmed by our experiments, since the ion beam is directed to the sample surface normal and the detector detects only ions scattered at an angle of 136°, so the sputtered atoms of the first atomic layer from the surface Mo(110) leads to decrease in the effective atomic density. However, when a sufficiently large number of atoms will be sputtered, dynamic equilibrium will be established, because accumulation of single vacancies should make the second atomic layer more open. For the Mo(100) surface, which is already quite "open", the possibility of backscattering from the second atomic layer after surface sputtering will be much greater. Thus, it becomes clear why decrease of the LEIS signal intensity after sputtering is more significant for the close-packed Mo(110) surface. Even at high doses of sputtering, the difference between the signal intensities from the different crystallographic surfaces still remains. This is partly due to the conservation of the structure in the bulk crystal, and partly due to the fact that ion etching not only makes the surface amorphized, but also removes a lot of layers. At a dose of 40x1015 ion cm-2, almost hundred atomic layers are removed from the surface, which far exceeds the range of thicknesses where Ne+ ions with energy of 3 keV could make the surface amorphized. Apparently, the result of these processes is dynamic equilibrium.
\n\t\t
\n\t\t
\n\t\t
\n\t\t
\n\t\t
\n\t\t
\n\t\t\t
\n\t\t\t\tTreatment\n\t\t\t
\n\t\t\t
\n\t\t\t\tRelative LEIS yield\n\t\t\t
\n\t\t\t
\n\t\t\t\tAtomic density (x1015 cm-2)\n\t\t\t
\n\t\t
\n\t\t
\n\t\t\t
Mo(110)
\n\t\t\t
Mo(100)
\n\t\t\t
Mo(110)
\n\t\t\t
Mo(100)
\n\t\t
\n\t\t
\n\t\t\t
\n\t\t\t\tAs sputtered\n\t\t\t
\n\t\t\t
0.73
\n\t\t\t
0.64
\n\t\t\t
1.02
\n\t\t\t
0.91
\n\t\t
\n\t\t
\n\t\t\t
\n\t\t\t\t700K, 1 min\n\t\t\t
\n\t\t\t
0.89
\n\t\t\t
0.64
\n\t\t\t
1.25
\n\t\t\t
0.91
\n\t\t
\n\t\t
\n\t\t\t
\n\t\t\t\t1000K, few seconds\n\t\t\t
\n\t\t\t
0.97
\n\t\t\t
0.64
\n\t\t\t
1.47
\n\t\t\t
0.91
\n\t\t
\n\t\t
\n\t\t\t
\n\t\t\t\t1300K, 3 minutes\n\t\t\t
\n\t\t\t
0.99
\n\t\t\t
0.73
\n\t\t\t
1.40
\n\t\t\t
1.03
\n\t\t
\n\t\t
\n\t\t\t
\n\t\t\t\t1600K, flash\n\t\t\t
\n\t\t\t
1.00
\n\t\t\t
0.76
\n\t\t\t
1.41
\n\t\t\t
1.07
\n\t\t
\n\t\t
\n\t\t\t
\n\t\t\t\t2500K, flash\n\t\t\t
\n\t\t\t
1.00
\n\t\t\t
0.76
\n\t\t\t
1.41
\n\t\t\t
1.07
\n\t\t
\n\t\t
\n\t\t\t
\n\t\t\t\tIdeal lattice, first atoms, normalized to (110)\n\t\t\t
\n\t\t\t
1.000
\n\t\t\t
0.707
\n\t\t\t
1,41
\n\t\t\t
1.00
\n\t\t
\n\t
Table 6.
The relative LEIS yields and atomic densities of the Mo(110) and Mo(100) after various annealing treatments.
After sputtering, the molybdenum bicrystal is annealed at different temperatures and scanned along the surface by the ion beam of Ne+ with energy 3 keV. In this case, the amplitude of the elastic peak is recorded as a function of the position of the ion beam (Figure 12b). Measurements show that recrystallization of the surface Mo(110) after ion bombardment begins at about 700°C and completed at about 1100°C, and for Mo(100) recrystallization starts at ~1300°C. After high temperature annealing (~2500°C) the signals are the same as in the initial undamaged clean surface. Based on this, it is supposed that the different surface structures have different mobility of atoms, and the difference of the signal intensities can be used as a measure that determines the amount of disorder in the surface. The high mobility of atoms in the upper atomic layer of Mo(110) is supported by the lower surface energy of the molybdenum “close”-packed structure (110) as compared to "open" Mo(100).
5. Growing tube single crystals of refractory metals
5.1. Main features of growing tungsten tubular single crystals
Shaped tungsten single crystals are used as screens of different shapes, inputs, crucibles, shapers and other products. There is considerable interest to profiled tubular shaped single crystals (primarily, of tungsten) in connection with their use in prospective designs of thermionic converters. The production of tubular tungsten single crystals from bulk cylindrical crystals by traditional machining (drilling, broaching) is extremely labor-intensive, low-tech and uneconomical process. Get such tubes pulling from the melt, for example, by Stepanov method, is impossible even for the reason that there are no available materials for the shaper. The only possibility to obtain single-crystalline tungsten tubes by crystallization from the melt is to use for this purpose EBFZM method. Various materials can be successfully applied in industry to create structures, machine parts and devices only if they can be given in the required shape. Such shaping of crystalline materials may be done of the solid material (rolling, forging, shaping by cutting, etc.) and liquid phase (casting, welding). The shaping methods are now widely used to obtain polycrystalline products. Recently, in science and technology becoming more widely used are single crystals in the form of plates, tubes, rods of various sizes. In principle, the single-crystalline tube may be cut out from a bulk single crystal by mechanical or electrical discharge machining. However, using such kinds of processing, the single crystal will inevitably contain multiple structural defects that can alter the properties of the crystal in an unpredictable manner. For example, during the electroerosion cut of tungsten single crystals a network of cracks in the sub-surface layer occurs, and the dislocation density increases. Furthermore, such treatments are inefficient; too much of waste material is usually lost. The low economic efficiency and non-technological methods have led to search of alternative methods of getting profiled single crystals. Among them are plastic deformation, epitaxial growth from the gaseous phase, crystallization from a molten solution, crystallization from the melt. Advantages of the latter forming method consist mainly in the higher productivity and better quality (because of both the structure and properties) of the final product. Crystallization from the melt provides the most perfect structure and high purity of single crystals because of the contact-less melting with no contaminating material at the front of crystallization (e.g., Czochralski method). However, due to the low stability of the capillary shaping this method can allows obtaining only products of the simplest form – the rods. Verneuil method, including plasma heating, allows obtaining single crystals of various materials in the form of tubes. It seems that the most suitable method for obtaining the tubular single crystals by crystallization from the melt is Stepanov method. The method consists in a capillary shaping of the column from the melt using a special shaper and its crystallization proceeds outside the container with the melt. Stepanov method has a significant margin of stability and enables the profiled metal and semiconductor crystals of high quality. A float zone method can also be used for crystallization of single crystal tubes from the melt. An example of using this method to obtain tubes can be found in the monograph by Pfann [8]. In principle, the float zone methods may use any heating source, but the most suitable method to obtain the tungsten tubular single crystals with thin walls is floating zone method with electron-beam heating [60-62]. Until now, by the method of EBFZM from the melt were grown the most perfect and the purest single crystals of tungsten and other refractory metals. Crystals obtained by this method typically have a cylindrical shape. EBFZM method seems to be the most promising for growing shaped single crystals of tungsten and other refractory metals in the form of tubes. Growing tubular crystals of tungsten was done on the set-up for EBFZM. Tungsten tubular feeds which were produced by CVD had an outer diameter of 16 mm and a wall thickness of 1.5 mm (a diameter of feeds varies from 10 to 22 mm). Seeds for growing single crystals were cut from the tubular cylindrical tungsten single crystals with the growth axis [111] and [001] by electroerosion, followed by removal of the damaged layer. Tubular crystals were grown in a vacuum higher than 10-4 Pa and at the rate of 4 mm min-1. A special tubular holder for the tubular feed and single crystal was developed (Figure 13).
Figure 13.
Device for growing tubular crystals.
The holder consists of the base 1, support shanks 3 and 6, the support rod 4, mounting screws 2 and 7. A small circular groove is performed on the base 1, through which it is possible quick and accurate align of the tubular feed. Since melting tubular feeds has some specific features, the relationship between the height of the liquid zone stability at EBFZM and the wall thickness is studied. Some prolixity (blurring) of these two areas is possible due to the presence of destabilizing factors leading to local overheating in the zone: defects of cathode filament, oscillations of the impurity content in samples, as well as misalignment of the sample, cathode and focusing elements. A lower limit is due to the fact that an effect of the electron beam cutting is observed with increasing the current density of the electron beam. The obtained experimental dependence allows with sufficient reliability to pick up the electrical parameters of melting using tubular specimens with the different diameters and wall thickness. In some cases, individual batches of feeds obtained by CVD have a high gas content which forced to resort to an additional step – the high-temperature vacuum annealing at pre-melting temperatures directly in the set-up. It turns out that without this preliminary operation the growth of tubular single crystals is impossible, since the escaping gases can tear off a liquid meniscus. A metallographic picture in Figure 14 shows the cross-section of the original CVD tubular feed after the above-described annealing operation (with partial melting). It shows also a clearly visible residual porosity. The assessment shows that for stable melting tubular feeds with a given wall thickness (from 0.5 to 1.5 mm) the zone height should be, respectively, from 2 to 4 mm. Naturally, these values meet the conditions of the focusing of the electron beam without local inhomogeneities in the density of the electron beam current.
Figure 14.
The cross-section of a tubular feed annealed.
The implementation of this condition is associated with great difficulties since it is necessary to supply large power to the tubular sample with a large radiating surface, which in turn affects the degree of superheating of the melt surface and the surface tension of the melt. Thus it is necessary to take into account the dependence of the stable zone height on superheating of the liquid metal, as well as decrease of viscosity of the liquid metal along with growing possibility of electron-beam cutting. Before the actual process of growing the tubular single crystal the radial heating by the filament of the electron gun should be carefully adjusted. The local density of the annular electron beam in either direction along the radius of no more than ±20% from the average current density, as shown in Figure 15.
Figure 15.
EB gun: optimal radial current density distribution.
When growing the tungsten tubular single crystals by seeding on a single crystalline seed of the desired crystallographic orientation, this operation is much more responsible than in the growth massive single crystals of cylindrical shape, since the presence of the slightest gap between the seed and the feed during welding them together can lead to rupture of the liquid meniscus. When growing tubular crystals without seeds, the grains from the base of the original CVD feed grow into the tubular crystal, and the high-angle boundaries tend to occupy the position of minimum energy, i.e., they lie along the growth axis in diametrically opposite planes (Figure 16).
Figure 16.
Single-crystalline (a) and polycrystalline (b) W tubes.
Thus obtained the polycrystalline tungsten tubes are very fragile and can be easily destroyed along the grain boundaries even from the weak strikes. When using the specially prepared single-crystal seeds it is possible to grow tubular single crystals of the length up to 180÷200 mm. The investigation of the real structure of the tubular single crystals of pure tungsten with the growth axes [111] and [001] is made by the metallographic and X-ray methods. In Figure 17 in the cross-section of the tubular single crystal, the low-angle boundaries are clearly seen, the majority of which begins and ends on the inner and outer surfaces of the tube.
Figure 17.
Low-angle boundaries in W tube crystal.
Subgrains originally contained in the seed have grown into a tubular single crystal, and their misorientation angles along the single crystal tend to be somewhat increased. A topogram of angular scanning of the cross-section of the tubular tungsten single crystal with the growth axis [111] is shown in Figure 18.
Figure 18.
Topogram of angular scanning of a cross-section of W tube crystal.
In the cross-section, there are several large subgrains of first order, separated by low-angle boundaries with the misorientation angles less than 1÷2°. Thus, the tungsten tubular single-crystals, obtained by EBFZM, at their crystallographic perfection are not inferior to the cylindrical tungsten single crystals obtained by the crystallization from the melt.
5.2. Features of capillary shaping in growing tubes
When growing single crystal at the initial portion of the tube at distances of about (1.5÷2)R1, where R1 is the outer radius of an initial feed, there is a portion of unsteady growth. The radius of the growing crystal is continuously changed until a steady-state mode. Figure 19 shows the process of growing the tubular sample on the stationary phase.
Figure 19.
Growing a tubular W sample on the stationary phase: 1-feed, 2–meniscus, 3–tube crystal.
By solving Laplace equation of capillary the connection of the outer and inner radii of the growing tube crystal can be found. Forming the tube crystal would be stable if the capillary constant a will be higher than the wall thickness [62], σ = 2500 erg cm-2 (the surface tension of the liquid W) and а =\n\t\t\t\t\t2σ/ρg=0.54 см (the capillary constant) [61]. In our case, the wall thickness of the initial feed is much less, and the fact that the height of the meniscus of the melt does not really exceed 3÷4 mm. So, it allows us, in a first approximation, to neglect by gravitational forces acting on the isothermal liquid meniscus. Using these simple limitations, it is posssible to obtain connection between the initial tubular feed and the growing crystal. In a steady state the growth angle φ0 = Const and the tube crystal with a constant cross-section can grow. The mathematical profile description of the outer surface of the liquid meniscus is of considerable interest. Since the weight of the melt is neglected, then there is only a thin liquid film stretched between two rings with radii R1\' and R1, spaced at a distance of S (the height of the meniscus). Now, the profile of the meniscus can be found, if Laplace equation will be written in polar coordinates:
∂2H/∂r2+(1/r)∂H/∂r=0E5
with boundary conditions Hr|r=R1=0;Hr|r=R1\'=S. Problem is completely analogous to the problem of electrostatics for potential distribution within the cylindrical capacitor, so the solution of the equation after some simple transformations can be written as Hr=Clnr/R1. Here, S = Cln(R1\'/R1); C = S/ln(R1\'/R1). As a result, the surface profile to have a liquid meniscus equation:
Hr=S/ln(R1\'/R1)xlnr/R1E6
\n\t\t\t\t
From which for the growth angle the equation can be written
The last equation can be written in a more convenient form:
S=tgπ/2-φ0R1lnR\'1E8
\n\t\t\t\t
Since the growth angle φ0is a constant of material, the last equation gives an unambiguous link between the outer radius of the feed and the outer radius of the tubular crystal growing at a given height of the liquid meniscus S. The ratio for the tube inner radius R2 is obtained from the law of mass conservation of (the difference between the density of the feed and the crystal, and evaporation losses are neglected)
R2=R12-R1\'2+R2\'2E9
\n\t\t\t\t
The results of calculations are shown in Figure 20. It can be seen that the radius of the growing tubular crystal can be controlled by changing the height of the meniscus depending on the change of the electron beam power.
Figure 20.
Dependence of radius of tube crystal on meniscus height.
The profile of the outer surface of the liquid meniscus is shown in Figure 21. According to measurements of the crystallized menisci the growth angle φ0 is evaluated. For tungsten, it is found to be 20±5°, which is used in the calculations. It should be noted that in actual experiments, the height of the liquid meniscus S depends on many parameters: the initial feed geometry, thermal properties of material, power, focusing the electron beam, etc. In general, the quantity of S can be obtained by solving the experimental scheme of Stephen, but this is extremely difficult and hardly advisable. It should also be noted that the tungsten tubular single crystal grown by EBFZM have not only the high structural perfection, but also have even surfaces. The maximum height of the profile does not exceed ~100 microns. Shown that by EBFZM method the bicrystals with low-angle tilt and twist boundaries can be grown, and if the sub-boundary located in a plane parallel to the growth axis of the crystal grown, they can travel from the seed on considerable distances in the body of the crystal. Thus, the misorientation usually somewhat increases. This process takes place when low-angle boundaries in the given plane can be established by more or less complete combination of lattice dislocations.
Figure 21.
Inner and outer profiles in the feed-melt-crystal system.
It was shown that EBFZM method implemented at the new set-up, it is possible to grow single single-crystalline tungsten tubes of the high crystallographic and geometric perfection. This is due to the fact that the process of a capillary forming in the case, shown in Figure 19, has a high stability as repeatedly confirmed experimentally. Due to changes in the electron beam power it can be quite widely vary the height of the liquid meniscus S, i.e., actually control of the diameter of the growing crystal. This gives us a hope that the process of growing single crystal tubes of refractory metals by EBFZM in perspective can be automatic that is particularly necessary in the case of the serial production of such products. Currently, the process of growing tubes by an operator control, which actually measures the relevant parameters: the meniscus height S and diameter of the growing tubular crystal 2R1 "by eye", which is totally inadequate in the sense of obtaining single-crystal tubes of specified geometrical sizes. Furthermore, if the growth process is in a stationary stage, and power of the electron beam with a high accuracy (±0.5% for setting "area") is maintained at a constant preset level, it does not mean that the crystal will grow of a constant cross-section. The shank and the free end of the tubular feed influence on the heat transfer from the liquid meniscus portion. As a result of change of the meniscus height S, and hence change of the diameter of the growing crystal is happened. The latter leads to presence in the tubular single crystal tapers of both signs. This is clearly seen in Figure 22. Obviously, the taper can be eliminated by an automatic control system of the growth process. For example, in growing single crystals of semiconductor materials by Czochralski or Stepanov such automatic systems are already widely used [7]. It should be noted that such a process parameter to measure the height of the meniscus is in any way unlikely. Measuring the diameter of the growing crystal is possible by means of an optical system or a TV monitor. The resulting signal from the sensor of the diameter is then used to synthesize an appropriate control signal to an analog control unit or microcomputer. One of the important parameters of the automatic control system is its speed. Obviously, in the case of growing tubes by EBFZM this value should be much smaller than the thermal time constant of the thermal process zone (the crystal plus the corresponding accessories). Since, as previously shown, the taper in mostly due to change of heat removal by conduction, it is possible to obtain the following estimate for the time constant of the form: τ = Q/χ, where, χ the thermal diffusivity, cm2 s-1; Q the cross-section of the crystal, cm2. For the tungsten tubular single crystal with the outer diameter of 16 mm, the wall thickness δ = 2 mm and the registered thermal time constant yields to τ = 4 s. Therefore, the creation of ACS for growing tubes by EBFZM with the rate much less than 4 s do not represent currently any technical difficulties. The system would eliminate defects like geometric tapers and grow single crystalline tubes of refractory metals by EBFZM with a deviation of the inner and outer diameters from the nominal value within ±200 microns, and getting these products on an industrial scale.
Figure 22.
W tubular single crystals with a growth axis [111], comprising one-two runs (a) and a tapering defect in the middle (b).
6. Key findings
The method is developed of growing bicrystals of refractory metals up to 150-200 mm in diameter and 15-25 mm with the desired crystallographic parameters - of misorientation angles and both the grain boundaries and bedding planes of boundaries. The method is based on stability and radial uniformity of power supplied to the sample by an electron gun, co-axiality of the growing bicrystal and the electron gun, and the uniformity of heat removal from the growing bicrystal. Proposed and tested three methods of preparing bicrystalline seeds allow to grow bicrystals of niobium, molybdenum and tungsten with crystallographic parameters within 1-2°. Shown that by EBFZM method can be grown the bicrystals with desired low-angle tilt and twist boundaries, and if sub-boundary is located in a plane parallel to the growth axis of the crystal grown, they can travel from the seed on considerable distances in the body of the crystal. Thus the misorientation usually somewhat increases. This process takes place when the small-angle boundary in the given plane can be established by more or less complete combination of lattice dislocations. It is shown that a new set-up meets the most stringent requirements to the electron-beam zone melting set-ups for the radial uniformity of heating, power stability, and production efficiency.
The thirty-years experience of growing single crystals, bicrystals, and tubular crystals with desired crystallographic parameters and geometry have shown that the developed EBFZM set-ups together with new electron-beam guns are of the successful design. They give an excellent possibility to grow any of single-crystalline samples of transition metals of diameter from 4 to 30 mm. These opportunities are determined primarily by the original circular electron guns for growing crystals of different diameters. The electron guns themselves have no restrictions in duration of their work and life and are essentially "eternal". Single crystals grown of all studied transition metals satisfy the highest requirements for both the chemical purity and structural perfection. Duration of the circular tungsten cathodes made of tungsten wire with a diameter of 0.8-1 mm is longer than 100 hours. Growing crystals up to 600 mm long is provided by the design of EBFZM set-ups. The main principle of designing the set-ups is the co-axiality of the cathode and anode assemblies throughout the whole length of the growing crystal. In other words, the geometric and thermal centers of the crystal and the melt should be matched, as well as high precision of moving mechanisms of both the anode and cathode assemblies and offset buckling and vibration as result of thermal effects.
Proposed and tested three methods of preparing bicrystalline seeds to grow bicrystals with controlled crystallographic parameters of high accuracy (up to 1-2°). The fracture strength of high-angle tilt and twist boundaries in the pure molybdenum bicrystals is low; special boundaries differ markedly from other boundaries on their strength: twin boundaries are several times stronger and boundaries with small numbers of coincident nodes have the lowest strength. The contents of interstitials at boundaries of high-angle misorientation, according to Auger electron spectroscopy, almost tenfold higher than their content in the grain volume. However, increasing the purity of molybdenum on interstitials does not lead to change in the fracture strength of grain boundaries. Shown that by EBFZM method can be grown bicrystals with low-angle tilt and twist boundaries.
Our results have shown that the combination of bicrystalline samples and low-energy ions scattering (LEIS) is very fruitful. The experimental results show that using bicrystals in combination with LEIS opens new possibilities for studying properties of surfaces. Experimentally shown that the LEIS signal intensity from the different crystallographic surfaces of molybdenum bicrystals is defined by both the atomic density of the uppermost atomic layer and its structure. Contributions of second and deeper layers in the LEIS signal are very small (<2%). After bombardment by the Ne+ ions with energy of 3 keV and different ion doses (from 7x1015 to 4x1016 ion cm-2) with current of 6x1012 ion cm-2 c-1, the difference between the LEIS signal intensities for molybdenum planes Mo(110) and Mo(100) remain at 10%, indicating partial damage of the surface. Rather, at such ion fluxes sputtering the surfaces occurs layer-by-layer. Our studies have shown that the processes can also be examined using the self-diffusion method of LEIS as the LEIS signal may be to some extent an indication of damage of the surface. Using this method the study of properties of the surface recrystallization can also be conducted. We have found that recrystallization of molybdenum surface Mo(110) begins at 750°C and of ~Mo (100) - at about 1300°C, indicating the different mobility of atoms in the uppermost atomic layers of different crystallographic orientations surface. Moreover, the LEIS signal intensity of the surface Mo(110) during sputtering drops to 75% of its initial level (for a clean surface free of damage), and of Mo(100) – to 90% only. It follows that the close-packed surface structure is more sensitive to these influences, which may be attributed to its low free energy.
The growing technology of tubular tungsten single crystals by EBFZM is developed. It is shown that capillary shaping of the tube crystals is stable. A crystallographic perfection of tungsten tubular single crystals is not inferior to the cylindrical single crystals, obtained by EBFZM. This is due to the fact that capillary forming is of high stability what is confirmed experimentally. Due to changes in power the height of the liquid meniscus can be widely varied what is very important to check the diameter of growing tubular crystals. This gives a hope that growing single crystalline tubes of transition metals by EBFZM can be automatic in perspective.
Acknowledgments
I want to express my acknowledgments to my colleagues and friends Boris Shipilevsky, Valery Semenov, Sergey Bozhko, Eugene Stinov, and Sergey Markin from ISSP RAS for the long cooperation in my life and science. I am very grateful to Hidde Brongersma, Honorary Professor of Physics of Technical University Eindhoven and Imperial College London, for fruitful discussions and cordial friendliness during many years of our life. I am very grateful to Victor Lomeyko, ISSP RAS, for his skillful engineering assistance at the most part of my scientific studies. I have to express my acknowledgments to the Russian Fund for Basic Research for financial support of the part of these studies.
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Introduction",level:"1"},{id:"sec_2",title:"2. Basic physical features of crystallization",level:"1"},{id:"sec_2_2",title:"2.1. Methods of growing single crystals from the melt",level:"2"},{id:"sec_3_2",title:"2.2. Mechanisms of crystallization of metals",level:"2"},{id:"sec_4_2",title:"2.3. Heat and mass transfer processes in crystal growth from the melt",level:"2"},{id:"sec_5_2",title:"2.4. Influence of convection in the melt on the crystal structure",level:"2"},{id:"sec_6_2",title:"2.5. Thermal stresses and dislocation structure of single crystals",level:"2"},{id:"sec_8",title:"3. Experimental",level:"1"},{id:"sec_8_2",title:"3.1. The set-ups for electron beam floating zone melting",level:"2"},{id:"sec_9_2",title:"3.2. Metallographic examinations",level:"2"},{id:"sec_10_2",title:"3.3. X-ray studies",level:"2"},{id:"sec_11_2",title:"3.4. Electron microscopy studies",level:"2"},{id:"sec_12_2",title:"3.5. Chemical purity",level:"2"},{id:"sec_14",title:"4. 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1. Introduction
Nociceptive phenomena associated with surgical trauma involve local and systemic inflammatory processes, activation of cellular and humoral immune mechanisms, and adrenergic and neuroendocrine activation. The activation of the glutaminergic pathway plays a determining role in secondary sensitization at the level of the central nervous system, which is responsible for nociceptive amplification, persistence of postoperative pain, and hyperalgesia.
Strategies to reduce perioperative opioid consumption and its consequent side effects have been based on the use of multimodal analgesia schemes. The development of opioid-free anesthesia (OFA) techniques, indicated for particular patient populations in which opioids may be harmful, requires the use of drug mixtures in which NMDA receptors (NMDAr) antagonists are integral. The most clinically used NMDAr inhibitors in anesthesia are ketamine and magnesium sulfate. Their co-administration in OFA techniques has synergistic analgesic effects. The concomitant use of intravenous lidocaine and dexmedetomidine provides additional benefits to the use of NMDAr antagonists to reduce the central sensitization phenomenon (SC), hyperalgesia and opioid-induced hyperalgesia (OIH).
2. NMDAr are involved in nociception even from the beginning of tissue trauma: peripheral hyperalgesia is an event modulated by a glutamatergic system in the dorsal root ganglia (DRG)
The nociceptive pathway undergoes important functional changes and modulation under surgical trauma (tissue damage and inflammation). This plasticity is mediated by many mechanisms, including peripheral and central sensitization. The paramount element for these modificationsis the result of release of many chemical mediators peripherally as well as neurotransmitters in the spinal cord and the brain [1].
Peripheral sensitization contributes to increased afferent stimulation of the spinal cord. It is mediated by many processes in which nerve tissues and immune cells act under a complex barrage of pain-mediating substances. The nociceptive impulse generated by an inflammatory event in peripheral tissue is regulated in the dorsal root ganglia (DRG) by a system that involves satellite glial cells and glutamatergic NMDA receptors (NMDAr) [2].
Mechanical inflammatory nociceptor sensitization is dependent on glutamate release in the DRG and subsequent NMDAr activation in satellite glial cells. That fact supports the idea that peripheral hyperalgesia is an event modulated by a glutamatergic system in the DRG. Moreover, retrograde sensitization of the primary sensory neuron has been proposed as an essential mechanism for induction and maintenance of peripheral inflammatory hyperalgesia. It has been suggested that this phenomenon is due to the release of glutamate in the spinal cord, which acts retrogradely on NMDARs present at the presynaptic terminals of the primary sensory neuron [3, 4, 5].
In summary, numerous receptors and ion channels are involved. Continued increased input to the spinal cord results in further central sensitizing changes.
3. What is the importance of glutaminergic pathway in the nociceptive process and secondary sensitization during surgical trauma?
The glutamate receptor NMDAr is the starting pointof secondary sensitization and the amplification of pain. Hence, the NMDAr may be a potential target for analgesic therapy in the context of opioid-free anesthesia and postoperative analgesia (OFAA).
The primary sensitization resulting from local inflammation of the tissue under surgical trauma activates the “asleep afferent” thereby increasing the total nociceptive afferent signals to the spinal cord, which is the beginning of the development of the central sensitization. The excitatory amino acid glutamate plays a central role both via the α-amino-3-hydroxy-5- methyl-4-isoxazolepropionate (AMPA) ion-channel linked receptor in acute pain transmission and via the N-methyl-d-aspartate (NMDA) receptor to mediate sensitizing effects. In the acute state, the NMDAr are limited by a voltage-dependent magnesium ion block of the channel. Increased afferent input from primary sensitization releases the magnesium ions and activates theNMDA receptors. NMDAr activation increases intracellular calcium flux and enhances the activation of the second-order neuron. The increase in intracellular calcium also stimulates cyclooxygenase, lipoxygenase and protein-kinases [2, 6].
Surgical stimulus activates C fibers and generatesa progressive build-up in the amplitude of response in dorsal horn neurons andbrings onthe Wind-up phenomenon, which is a specific initiator of central sensitization [1].
4. How does the glutaminergic pathway mediate the persistence of pain after surgery and chronic pain?
Neuropeptides like substance P and the calcitonin gene-related peptide (CGRP), released from primary afferent neurons, contribute to the activation of the NMDAr in pain states. Neuropeptides such as neurokinin A and B act on NK receptors and activate the NMDAr directly by inducing decreased potassium ion conductance and phosphorylation-induced increases of intracellular calcium, facilitating central sensitization and hyperalgesia. Brain-derived neurotrophic factor (BDNF) is produced by nerve growth factor (NGF)-dependent nociceptors and increases the glial inflammation. Moreover, BDNF augments spinal neuron excitability by phosphorylation-mediated stimulation of the NMDAr.
Finally, longer-term changes of central sensitization may be explained by transcriptional changes.
Hence, the significance ofthe spinal cord as a location for an anti-hyperalgesic approach leads us consider the important role the NMDA receptors have in central sensitization and their potential usefulness as a focus of analgesic therapeutics [7, 8].
Ketamine and magnesium sulfate are the most frequently used NMDAr antagonist drugs in anesthesia. Ketamine in association with lidocaine and dexmedetomidine infusions have led to the development of opioid-free anesthetic techniques (OFA). Moreover, the combination of low doses of ketamine with these adjuvant medications have shown an important opioid-sparing effect on postoperative pain control and has an additional anti-hyperalgesic effect [8].
5. Why should opioid use be minimized during the perioperative period?
Intravenous opioids are the commonly used analgesics during general anesthesia along with hypnotic drugs. Opioids provide potent analgesia, attenuate the neuro-endocrine response triggered by surgery, and provide hemodynamic stability. However, these drugs have side effects like nausea, vomiting, decreased intestinal peristalsis, respiratory depression, histamine release and opioid-induced hyperalgesia mediated by NMDAr stimulation [6].
Multimodal postoperative analgesia has been the gold standard for more than 20 years. It makes for opioid-sparing and better outcomes than with drugs like morphine that are administered as a sole analgesic agent after surgery. OFA is based on the association of drugs and/or techniques that makes for good quality general anesthesia with no need for opioids. The association can combine NMDAr antagonists (ketamine, lidocaine, magnesium sulfate), sodium channel blockers (local anesthetics), anti-inflammatory drugs (NSAID, dexamethasone, lidocaine) and alpha-2 agonists (dexmedetomidine, clonidine) [9].
There is a group of patients in whom opioid use is relatively contraindicated. It is comprised of those with gastrointestinal intolerance susceptible to developing intestinal ileus, functional bladder disorders, a history of severe nausea and vomiting, sleep apnea syndrome, morbid obese, patients with mast cell activation syndrome (MCAS), autonomic symptoms like postural orthostatic tachycardia syndrome (POTS), patients with chronic pain, chronic fatigue syndrome and myalgic encephalomyelitis, patients with high-dose opioid use, opioid tolerance, opioid-induced hyperalgesia (OIH) and patients who are prone to drug dependence [9, 10, 11, 12, 13].
The above patients benefit from OFAA techniques. When feasible, the use of regional anesthesia is helpful. Then again, the substitution of opioids for analgesic drugs with different mechanisms of action is desirable when general anesthesia is indicated [14, 15].
6. Ketamine, magnesium, lidocaine and dexmedetomidine: an anti-hyperalgesic combination
Ketamine plays a fundamental role in OFA techniques since it is a potent NMDAr inhibitor that provides an excellent analgesic effect at sub-anesthetic doses. Since ketamine can cause dose-dependent side effects (cardiovascular excitation, hallucinations, psychomimetic events, nausea and vomiting as well as hyper-salivation), it is advisable to associate it with other NMDAr antagonists like magnesium sulfate or dextromethorphan to enhance its analgesic effect with lower doses.
Ketamine and magnesium have been widely described as improving postopera-pain control. The literature has consistently reported that both drugs provide effective postoperative analgesia and a reduction in opioid consumption. A meta-analysis that aggregated data from 2482 patients showed that intravenous ketamine reduces postoperative opioid use by 40% [16]. Similar results have been shown with the administration of intravenous magnesium [17, 18, 19].
Furthermore, experiments on the association of ketamine and magnesium may give us an important clue as to the useful of the association. In fact, pretreatment with ketamine has been demonstrated to improve the anti-nociceptive effect of magnesium [20]. Interestingly, myocardial and endothelial cells express NMDA receptor. Thus, a synergistic effect can be expected on the NMDA receptor in the cardiovascular system with the resulting cardiovascular stability by the competitive blocking actions of drugs [21, 22].
On the other hand, there are many publications that describe the use of intravenous lidocaine as a systemic analgesic with particular attenuating effects on the intraoperative inflammatory reaction at multiple levels (i.e., reduction of inflammatory biomarkers by direct action on cell membrane of monocytes, neutrophils and mast cell, PKC-mediated reduction of Ca++ intracellular influx and K+A-channels, action over cholinergic, adrenergic, GABAergic, NMDAr, and NK-1r pathways, etc.). Lidocaine has a non-relevant analgesic effect mediated by Na+-channel blocks at therapeutic plasmatic concentrations [10, 23, 24].
Additionally, lidocaine modulates the immune response to surgical trauma with benefits in term of cancer recurrence. So, it is advisable to associate the intravenous infusion of lidocaine along with dexamethasone plus non-steroidal anti-inflammatory drugs (NSAIDs) to complement the analgesic effect of NMDA antagonists through the reduction of inflammation due to surgical trauma. Moreover, it has been shown that the intravenous lidocaine reduces the requirements for hypnotic drugs (propofol or sevoflurane) and has a dose-dependent anti-NMDAr effect [25, 26, 27, 28, 29, 30, 31].
Dexmedetomidine is an alpha-2 adrenergic agonist which acts at different levels of the nociceptive pathway like on the peripheral nerves, pre-synaptic receptors at the dorsal horn of the spinal cord and at the supraspinal level (Locus Coeruleus). The association of dexmedetomidine with OFA may provide additional benefits. They encompass the attenuation of the sympathetic nervous system, a reduction in intraoperative catecholamines release, a decrease in the requirements for hypnotics (propofol or inhalation anesthetics) due to its sedative effects, decreases in the post-operative psychomimetic side-effects of ketamine, the prevention of postoperative delirium and shivering [32, 33].
Meta-analyses have shown that clonidine and dexmedetomidine provide analgesia with an added opioid-sparing effect and PONV reduction [34, 35].
The authors has been using the OFAA protocol on patients with a medical history of postoperative nausea and vomiting, ERAS protocols in complex laparoscopic surgery that include bariatric surgery and patients with chronic pain, opioid treatment and OIH who are to undergo extensive/complex spinal surgery. The outcomes of our patients have undergone complex gastro-intestinal surgery have been consistent with the published literature. An important reduction in nausea and vomiting (20%), a faster recovery from intestinal peristalsis, adecrease in ileus and acute gastric remnant dilatation, and a reduction in the post-operative use of opioid rescue (30%) have been recorded in our case-series [36, 37, 38].
7. Is it feasible to provide a perioperative management focusing on anti-hyperalgesia and central sensitization for patient with chronic pain who are to undergo major spinal surgery?
Patients with severe spinal deformities like scoliosis, and cranio-cervical-thoracic instability due to connective tissue defects and Joint Hypermobility Syndrome often suffer from widespread chronic pain and hyperalgesia. In patients with Joint Hypermobility Syndrome (JHS) who developed cranio-cervical instability (CCI), both severe craniocervical pain and widespread pain (i.e., somatic/neuropathic/visceral), have multi-factorial causes, that are strongly related to chronic nociceptive neuro-inflammation, glial activation and neuronal plasticity in the spinal cordas well as in the brainstem and brain that lead to a common final pathway, which is the Central Sensitization phenomena (CS) [7, 10].
Furthermore, many patients with CCI, JHS, chronic fatigue and severe chronic pain receive different types of opioids, which further complicates pain due to OIH. Sometimes, these patients may suffer from a category of pain known as central intractable pain. It is a painful condition that does not respond to opioids and their use may even be detrimental to the patient [6, 7].
Therefore, considering the probable mechanisms of the chronic pain (CS and OIH) that affect patients with JHS and CCI as well as their frequent association with MCAS and POTS, the use of opioids in total intravenous anesthesia (TIVA) during occipitocervical~thoracic fixation (OCF) was halted in our practice. Intra-operative opioid-based analgesia has been replaced by infusions of lidocaine, ketamine, magnesium, dexmedetomidine and propofol as hypnotic [10, 39]. As stated before, they are coadjuvants with known anti-hyperalgesic properties. This OFAA protocol aims at improving postoperative pain control, minimizing postoperative opioid rescues and reducing preoperative opioid doses in those patients who have been prescribed those drugs over a long period (Figure 1).
Figure 1.
Opioid-free anesthesia and analgesia (OFAA) vs. opioid based anesthesia and analgesia (OP) protocols for patients with joint hypermobility syndrome undergoing craneo-cervical fixation. Adapted from Ramírez-Paesano C., et al. [39].
Infusions of lidocaine, ketamine and dexmedetomidine are continued at lower doses during the post-operative period (for a maximum of one week) as part of a multimodal analgesia plan [10, 39]. The continued perioperative use of a lidocaine, ketamine and dexmedetomidine infusion and the gradual reduction of the doses over one week might overcome the peak of the inflammatory surgical-response. Therefore, its effect on pain and Central Sensitizationis to minimize opioid exposure and result in a reduction of VAS [8, 39, 40, 41, 42, 43].
In a case-series study of 42 patients with JHS that have undergone OCF [39], the authors found a lower VAS in the OFA group in the postoperative time (p < 0.001). The reduction in the VAS was more significanton the 1st postoperative day in the OFA group 5.35 (4.83–5.86) vs. the Opioid group (OP) 7.89 (7.56–8.23) (p < 0.001), meaning up to 32% decrease in the VAS of the OFA group. TheVAS at hospital-discharge was lower in the OFA group: 4.96 (4.54–5.37) vs. OP group: 6.39 (6.07–6.71) (p < 0.001). The methadone requirement was lower in the OFAgroup (p < 0.001). No methadone rescue was needed with 78% (IC 95%)of patients in OFA group. On the contrary, 95% (IC95%) in the OP group needed methadone rescue at high doses. The OFA group showed decreased ileus, nausea and vomiting (p < 0.001). Compared with preoperative values, there were decreased opioid requirements for 60.9% in the OFA group at hospital-discharge. A 77% reduction of anxiolytics requirements was also seen. In the OFA group, 17.4% (n = 4) of patients had visual hallucinations. Haloperidol was used in two patients [39].
The doses of lidocaine, ketamine, magnesium and dexmedetomidine proposed in the author’s protocol seems to be a combination with balanced anti-nociceptive synergism. It coincides with recent publications that describe lidocaine, ketamine, dexmedetomidine and MgSO4 as the best options in both obese patients and complex spine surgery [23, 44].
According to the literature, there is more consensus on the benefits of OFA use in bariatric surgery or complex laparoscopy surgery. In term of the reduction of postoperative opioid requirements and a better recovery, the controversies that surround the benefits of OFA in major spinal surgery may be due to the diversity of surgicalprocedures, the varying degrees of complexity of the cases and the exceptionally varied use of coadjuvants for post-operative multi-modal analgesia. However, there is strong evidence that opioid-inclusive anesthesia does not reduce postoperative pain but is associated with more side effects in comparison with the opioid minimizing approach. OFA management should be evaluated on a case-by-case basis.
With the current evidence, OFA management could not be confirmed as an independent factor in reducing postoperative pain in all the surgical settings in which it has been used. However, OFA management plus postoperative use of lidocaine, ketamine, and dexmedetomidine infusions (OFAA) as part of robust multimodal analgesia may explain the results seen in patients with extensive chronic pain, hyperalgesia and Central Sensitization phenomena [10, 39, 45, 46].
8. Is it possible to use some opioid as postoperative rescue in OFAA?
Many times patients undergoing extensive surgery require postoperative opioids as rescue for breakthrough pain control. The OFAA protocol used in our hospital includes methadone as rescue for severe postoperative pain [10, 39]. We believe that methadone is the most suitable opioid to use as rescue analgesic for severe pain due to its anti-MNDAr effect. Methadone decreases OIH and attenuates the central sensitization phenomenon. It also has a reducing effect on the reuptake of serotonin and norepinephrine. All these mechanisms of action make methadone a suitable opioid for use in OFAA protocols. In addition, the use of methadone with ketamine (both anti-NMDAr) shows a “boosting” and synergistic effect that enhances the opioid-sparing effect [47].
Recent publications have recommended the use of methadone (0.15–0.2 mg/kg bolus) at the start of anesthetic induction in complex spinal surgery [48]. Methadone has been shown to provide a postoperative opioid-sparing effect and improved pain control. These benefits appear to persist for months after surgery compared to other opioids such as morphine or hydromorphone [49].
A recent meta-analysis confirms the benefits of methadone use at the onset of anesthesia in extensive and painful surgeries [50, 51].
9. Are there some contraindications to the use of OFAA?
We should be noted that OFAA is no applicable to all patients. OFAA is relatively contraindicated in patients with node blocks, autonomous nervous system disfunctions including orthostatic hypotension as seen in patients with multiple systemic atrophy disease. Furthermore, OFAA should not be administered to patients with coronary stenosis or acute coronary isquemia as well as patients with hemodynamic instability, increased intracranial pressure or polytrauma. The peripheral vasodilation caused by OFAA which could limit the perfusion of vital organs [52]. Finally, OFAA should not be administered to patients who have known allergies to some of its components.
10. What can be found in the literature on the risks and benefits of OFAA?
There is uncertainty in the literature on the balance between OFA benefits and risks. Some systematic reviews have shown an improvement in the incidence of postoperative pain, nausea and vomiting [53]. However, alpha-2-receptor agonists such as Dexmedetomidine or clonidine may be responsible of some side effects such as hypotension, bradycardia and sedation. Therefore, the safety of OFAA has been questioned [53, 54, 55]. The authors have not observed the aforementioned complications with the use of dexmedetomidine, probably because we did not administer starting boluses, and the maintenance doses used were limited to 0.2–0.3 mcg/kg/h.
A Meta-Analysis of randomized controlled trials including 2209 participants comparing OFAA to opioid based anesthesia (OBA) found no clinically significant effect of OFA on acute pain and opioid use after surgery in a large sample of studies. However, it found clinically important reductions in postoperative nausea, vomiting, shivering and sedation incidence showing a beneficial impact on postoperative patient comfort [56]. Definitive evidence-based conclusions related to the use of OFAA are still lacking. For this reason, it is important to continue exploring how to prevent its side effects as well as possible alternatives.
11. Conclusion
The activation of the glutaminergic pathway plays a determining role in secondary sensitization at the level of the central nervous system, which is responsible for nociceptive amplification, persistence of postoperative pain, and hyperalgesia.
The development of opioid-free anesthesia techniques, indicated for particular patient populations in which opioids may be harmful, requires the use of drug mixtures in which NMDAr antagonists are essential.
The most clinically used NMDA receptor inhibitors in anesthesia are ketamine and magnesium sulfate. They are the cornerstone to reduce or avoid the SC phenomenon, hyperalgesia and OIH in the surgical setting. Their co-administration in OFA techniques has synergistic analgesic and anti-hyperalgesic effects. The concomitant use of intravenous lidocaine and dexmedetomidine provides additional benefits to the use of NMDAr antagonists.
The authors consider that OFA has precise indications. However, the use of regional anesthetic techniques (whenever possible) or the use of intravenous mixtures with anti-hyperalgesic and opioid-sparing effects should be used, ifpossible, in patients with a history of chronic pain or with central sensitization phenomena and hyperalgesia who are to undergo extensive and very painful surgeries. Finally, methadone is a suitable opioid for use in modified OFAA protocols because its anti-NMDAr action and opioid-sparing effect.
Acknowledgments
The authorsthanks bariatric and spinal surgeons at Centro MedicoTeknon for their support in developing our OFAA protocol. We are also grateful tothe anesthesia/analgesia nursing team of “Anestalia”, without them our OFAA protocol could not have been implemented.
Conflict of interest
The authors declare no conflict of interest and no funding.
\n',keywords:"Opioid-free anesthesia, OFA, Opioid-free anesthesia and analgesia, OFAA, minimizing-opioid-use, NMDA-receptors antagonists, ketamine-magnesium-lidocaine-dexmedetomidine-methadone, anti-hyperalgesia, central sensitization, opioid intolerance, opioid-induced hyperalgesia, craneocervical/thoracic fixation, complex spine surgery",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/78897.pdf",chapterXML:"https://mts.intechopen.com/source/xml/78897.xml",downloadPdfUrl:"/chapter/pdf-download/78897",previewPdfUrl:"/chapter/pdf-preview/78897",totalDownloads:84,totalViews:0,totalCrossrefCites:0,dateSubmitted:"June 26th 2021",dateReviewed:"September 12th 2021",datePrePublished:"October 18th 2021",datePublished:null,dateFinished:"October 8th 2021",readingETA:"0",abstract:"There is increasing evidence of the close relationship between persistent activation of the glutaminergic pathway, central sensitization, hyperalgesia and chronic pain. Opioids have long been the standard analgesics used in the perioperative. However, their side effects, namely opioid-induced hyperalgesia, opioid tolerance and post-operative dependence in patients with chronic pain that are to undergo aggressive surgeries have motivated anesthesiologists to develop alternative anesthetic techniques. They include analgesic and anti-inflammatory drugs that act by modulating the nociceptive pathways with an opioid-sparing effect and even opioid-free anesthesia (OFA). In OFA plus postoperative analgesia (OFAA) techniques, ketamine plays a fundamental role as an analgesic with its antagonist action on the N-Methyl-D-Aspartate-receptors (NMDAr). However, ketamine is limited to use at sub-anesthetic doses (“low-doses”) due to its dose-dependent side effects. Consequently, other analgesic drugs with anti-NMDAr effects like magnesium sulfate and other non-opioid analgesics such as lidocaine and alpha-2-adrenergic agonists are often used in OFAA techniques. The aim of this text is to present a summary of the importance of the use of ketamine in OFA based on nociceptive pathophysiology. Additionally, the perioperative protocol (OFAA) with the anti-hyperalgesic approach of ketamine, lidocaine and dexmedetomidine co-administration in our center will be described. Some of the main indications for the OFAA protocol will be mentioned.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/78897",risUrl:"/chapter/ris/78897",signatures:"Carlos Ramírez-Paesano, Claudia Rodiera Clarens, José Carlos Torres Mandujano, Milen Bonev Bonev, Karen Salazar Loaiza, Florencia Borghetti, María Martínez Alberici, Josep Rodiera Olive and Jesus Santaliestra Fierro",book:{id:"11036",type:"book",title:"Ketamine Revisited - New Insights into NMDA Inhibitors",subtitle:null,fullTitle:"Ketamine Revisited - New Insights into NMDA Inhibitors",slug:null,publishedDate:null,bookSignature:"Dr. Nieves Saiz-Sapena and Dr. Manuel Granell Gil",coverURL:"https://cdn.intechopen.com/books/images_new/11036.jpg",licenceType:"CC BY 3.0",editedByType:null,isbn:"978-1-83962-793-4",printIsbn:"978-1-83962-792-7",pdfIsbn:"978-1-83962-831-3",isAvailableForWebshopOrdering:!0,editors:[{id:"204651",title:"Dr.",name:"Nieves",middleName:null,surname:"Saiz-Sapena",slug:"nieves-saiz-sapena",fullName:"Nieves Saiz-Sapena"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:null,sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. NMDAr are involved in nociception even from the beginning of tissue trauma: peripheral hyperalgesia is an event modulated by a glutamatergic system in the dorsal root ganglia (DRG)",level:"1"},{id:"sec_3",title:"3. What is the importance of glutaminergic pathway in the nociceptive process and secondary sensitization during surgical trauma?",level:"1"},{id:"sec_4",title:"4. How does the glutaminergic pathway mediate the persistence of pain after surgery and chronic pain?",level:"1"},{id:"sec_5",title:"5. Why should opioid use be minimized during the perioperative period?",level:"1"},{id:"sec_6",title:"6. Ketamine, magnesium, lidocaine and dexmedetomidine: an anti-hyperalgesic combination",level:"1"},{id:"sec_7",title:"7. Is it feasible to provide a perioperative management focusing on anti-hyperalgesia and central sensitization for patient with chronic pain who are to undergo major spinal surgery?",level:"1"},{id:"sec_8",title:"8. Is it possible to use some opioid as postoperative rescue in OFAA?",level:"1"},{id:"sec_9",title:"9. Are there some contraindications to the use of OFAA?",level:"1"},{id:"sec_10",title:"10. What can be found in the literature on the risks and benefits of OFAA?",level:"1"},{id:"sec_11",title:"11. Conclusion",level:"1"},{id:"sec_12",title:"Acknowledgments",level:"1"},{id:"sec_15",title:"Conflict of interest",level:"1"}],chapterReferences:[{id:"B1",body:'Farquhar-Smith Paul W. Anatomy, physiology and pharmacology of pain.Anaesth and Intensive Care Med. 2007; 9:1.'},{id:"B2",body:'Ferrari LF, Lotufo CM, Araldi D, Marcos A. Rodrigues MA. et al. Inflammatory sensitization of nociceptors depends on activation of NMDA receptors in DRG satellite cells.PNAS. 2014; 111(51): 18365. www.pnas.org/cgi/doi/10.1073/pnas.1420601111'},{id:"B3",body:'Ferreira SH, Lorenzetti BB. Glutamate spinal retrograde sensitization of primary sensory neurons associated with nociception. 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Perioperative systemic magnesium to minimize postoperative pain: a meta-analysis of randomized controlled trials. Anesthesiology 2013;119 (1):178e90.'},{id:"B20",body:'Savic Vujovic KR, Vuckovic S, Srebro D, et al. A synergistic interaction between magnesium sulphate and ketamine on the inhibition of acute nociception in rats. Eur Rev Med Pharmacol Sci 2015;19(13):2503e9.'},{id:"B21",body:'Makhro A, Tian Q, Kaestner L, et al. Cardiac N-methyl D-aspartate receptors as a pharmacological target. J Cardiovasc Pharmacol 2016 Nov;68(5):356e73.'},{id:"B22",body:'Chen JT, Chen TG, Chang YC, et al. Roles of NMDARs in maintenance of the mouse cerebrovascular endothelial cell constructed tight junction barrier. Toxicol 2016 Jan 2;339:40e50.'},{id:"B23",body:'Farag E, Ghobrial M, Sessler DI, et al. Effect of perioperative intravenous lidocaine administration on pain, opioid consumption, and quality of life after complex spine surgery. Anesthesiology. 2013; 119: 932-940.'},{id:"B24",body:'Eipe N, Gupta S, Penning J. Intravenous lidocaine for acute pain: an evidence-based clinical update. BJA Education. 2016; 16: 292-298.'},{id:"B25",body:'Hans G.A., LauwickS.M., Kaba A.,et al. Intravenous lidocaine infusion reduces bispectral index-guided requirements of propofol only during surgical stimulation.Br J Anaesth. 2010; 105: 471-479'},{id:"B26",body:'Dunn L.K, Durieux M.E. Perioperative use of intravenous lidocaine Anesthesiology. 2017; 126: 729-737'},{id:"B27",body:'Altermatt F.R., Bugedo D.A., Delfino A.E. et al. Evaluation of the effect of intravenous lidocaine on propofol requirements during total intravenous anaesthesia as measured by bispectral index.Br J Anaesth. 2012; 108: 979-983'},{id:"B28",body:'Forster C, Vanhaudenhuyse A, Gast P, et al. 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Opioid-free anesthesia for patients with joint hypermobility syndrome undergoing craneo-cervical fixation: a case-series study focused on anti-hyperalgesic approach. Orphanet J Rare Dis 2021;16:172. https://doi.org/10.1186/s13023-021-01795-4'},{id:"B40",body:'Mitra R, Prabhakar H, Rath GP, et al. A comparative study between intraoperative low-dose ketamine and dexmedetomidine, as an anaesthetic adjuvant in lumbar spine instrumentation surgery for the post-operative analgesic requirement. J Neuroanaesthesiol Crit Care. 2017;4:91-98.'},{id:"B41",body:'Cassuto J, Sinclair R, Bonderovick M. Anti-inflamatory of local anesthesia and their present and potential clinical indications. Acta Anaesthesiol Scand. 2006;50:265-282.'},{id:"B42",body:'Feizerfan A. Transition from acute to chronic pain. ContEducAnaesth Crit Care Pain. 2015;15(2):98-102. https://doi.org/10.1093/bjaceaccp/mku044.'},{id:"B43",body:'Meiler S, Monk T, Mayfield JB, Head A. Can we alter long-term outcome? The role of inflammation and immunity in the perioperative period (Part II). APSF Newsletter. Spring. 2004;19(1):1-16.'},{id:"B44",body:'Baek S Y, Kim J W, Kim T W, Han W, et al. Opioid-free anesthesia with a mixture of dexmedetomidine, ketamine, and lidocaine in one syringe for surgery in obese patients. J Int Med Res. 2020; 48(10) 1-8. DOI: 10.1177/0300060520967830'},{id:"B45",body:'Frauenknecht J, Kirkham KR, Albrech A,E. Analgesic impact of intra-operative opioids vs. opioid-free anaesthesia: a systematic review and meta-analysis. Anaesthesia. 2019; 75:651-662.'},{id:"B46",body:'Maheshwari K, Avitsian R, Sessler DI, Makarova N, et al. Multimodal analgesic regimen for spine surgery: a randomized placebo-controlled trial. Anesthesiology. 2020;132: 992-1002.'},{id:"B47",body:'Kharasch E D, Clark JD. Methadone and Ketamine: Boosting Benefits and StillMore to Learn. Anesthesiology 2021; 134:676-679.DOI: 10.1097/ALN.0000000000003752'},{id:"B48",body:'Glenn S. Murphy G S, Avram M J, Greenberg S B, et al. Perioperative Methadoneand Ketamine for Postoperative Pain Control in Spinal Surgical Patients A Randomized, Double-blind, Placebo-controlled Trial.Anesthesiology 2021; 134:697-708'},{id:"B49",body:'Murphy G S, Avram M J, Greenberg S B, Shear T D, Mark A, Deshur M A, et al. Postoperative Pain and Analgesic Requirements in the First Year after Intraoperative Methadone for Complex Spine and Cardiac Surgery. Anesthesiology 2020; 132:330-342'},{id:"B50",body:'Machado F C, Vieira J E, de Orange F A et al. Intraoperative Methadone Reduces Pain and Opioid Consumption in Acute Postoperative Pain: A Systematic Review and Meta-analysis. AnesthAnalg. 2019;129:1723-1732'},{id:"B51",body:'Murphy G S, Wu Ch L, Mascha E J. Methadone: New Indications for an Old Drug? Anesth Analg. 2019;129(6):1456-1458. DOI: 10.1213/ANE.0000000000004472'},{id:"B52",body:'Mulier J. Opioid free general anesthesia: A paradigm shift? 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Opioid free anesthesia Benefit-Risk Balance: A Sytematic review and Meta-Analysis of Randomized Controlled Trials. J. Clin Med. 2021, 10, 2069. http://doi.org/10.3390/jcm10102069'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Carlos Ramírez-Paesano",address:"cramirez@anestalia.com",affiliation:'
Anesthesiology Department (Anestalia), Centro Médico Teknon (Quironsalud Group), Barcelona, Spain
Anesthesiology Department (Anestalia), Centro Médico Teknon (Quironsalud Group), Barcelona, Spain
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Restoration",slug:"soil-fauna-diversity-function-soil-degradation-biological-indices-soil-restoration",totalDownloads:7783,totalCrossrefCites:27,totalDimensionsCites:59,abstract:null,book:{id:"3007",slug:"biodiversity-conservation-and-utilization-in-a-diverse-world",title:"Biodiversity Conservation and Utilization in a Diverse World",fullTitle:"Biodiversity Conservation and Utilization in a Diverse World"},signatures:"Cristina Menta",authors:[{id:"145410",title:"PhD.",name:"Cristina",middleName:null,surname:"Menta",slug:"cristina-menta",fullName:"Cristina Menta"}]},{id:"46202",doi:"10.5772/57425",title:"Marine Ecosystem Diversity in the Arabian Gulf: Threats and Conservation",slug:"marine-ecosystem-diversity-in-the-arabian-gulf-threats-and-conservation",totalDownloads:4780,totalCrossrefCites:19,totalDimensionsCites:48,abstract:null,book:{id:"3821",slug:"biodiversity-the-dynamic-balance-of-the-planet",title:"Biodiversity",fullTitle:"Biodiversity - The Dynamic Balance of the 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Braga, Hugo Bornatowski and Jean R. S. Vitule",authors:[{id:"58022",title:"Dr.",name:"Jean Ricardo Simões",middleName:null,surname:"Vitule",slug:"jean-ricardo-simoes-vitule",fullName:"Jean Ricardo Simões Vitule"},{id:"61834",title:"Dr.",name:"Vinicius",middleName:null,surname:"Abilhoa",slug:"vinicius-abilhoa",fullName:"Vinicius Abilhoa"},{id:"123966",title:"Dr.",name:"Hugo",middleName:null,surname:"Bornatowski",slug:"hugo-bornatowski",fullName:"Hugo Bornatowski"},{id:"123968",title:"BSc.",name:"Raul",middleName:"Rennó",surname:"Braga",slug:"raul-braga",fullName:"Raul Braga"}]},{id:"38670",doi:"10.5772/48351",title:"Efforts to Combat Wild Animals Trafficking in Brazil",slug:"efforts-to-combat-wild-animals-trafficking-in-brazil",totalDownloads:4690,totalCrossrefCites:9,totalDimensionsCites:32,abstract:null,book:{id:"2719",slug:"biodiversity-enrichment-in-a-diverse-world",title:"Biodiversity Enrichment in a Diverse World",fullTitle:"Biodiversity Enrichment in a Diverse World"},signatures:"Guilherme Fernando Gomes Destro, Tatiana Lucena Pimentel, Raquel Monti Sabaini, Roberto Cabral Borges and Raquel Barreto",authors:[{id:"142735",title:"M.Sc.",name:"Guilherme Fernando",middleName:null,surname:"Gomes Destro",slug:"guilherme-fernando-gomes-destro",fullName:"Guilherme Fernando Gomes Destro"},{id:"148026",title:"Ms.",name:"Raquel",middleName:null,surname:"Monti Sabaini",slug:"raquel-monti-sabaini",fullName:"Raquel Monti Sabaini"},{id:"148027",title:"MSc.",name:"Roberto",middleName:null,surname:"Cabral Borges",slug:"roberto-cabral-borges",fullName:"Roberto Cabral Borges"},{id:"148028",title:"MSc.",name:"Raquel",middleName:null,surname:"Barreto",slug:"raquel-barreto",fullName:"Raquel Barreto"},{id:"154825",title:"MSc.",name:"Tatiana Lucena",middleName:null,surname:"Pimentel",slug:"tatiana-lucena-pimentel",fullName:"Tatiana Lucena Pimentel"}]}],mostDownloadedChaptersLast30Days:[{id:"56873",title:"Impacts of Climate Change and Climate Variability on Wildlife Resources in Southern Africa: Experience from Selected Protected Areas in Zimbabwe",slug:"impacts-of-climate-change-and-climate-variability-on-wildlife-resources-in-southern-africa-experienc",totalDownloads:3363,totalCrossrefCites:7,totalDimensionsCites:14,abstract:"Climate change and variability pose a threat to wildlife resources in semi-arid savannahs. With examples from selected protected areas in Southern Africa, this chapter highlights studies on detected climate changes particularly rainfall and temperature, outlines the predicted and observed impacts of climate change and variability on wildlife resources in savannah ecosystems and highlights the adaptation and mitigation strategies and implications for conservation. Literature indicates that Southern Africa is characterised by highly variable, erratic and unpredictable rainfall and increasing temperature coupled with an increasing trend in climate-related extreme events such as frequent droughts, cyclones and heat waves. Drought, in particular, has led to death in several wildlife species. This has implications on long-term survival of the species. Changes in rainfall and temperature patterns influence habitat quality and consequently abundance of distribution of wildlife species. Large herbivores such as elephants and hippopotamus in particular are vulnerable to climate change due to their ecology, whereas other species are less vulnerable. Climate-related extreme events, coupled with other anthropogenic stressors, interact to influence changes in abundance and distribution of wildlife resources. Understanding the influence of these climatic factors on wildlife resources is vital for adaptive management and protection of biodiversity.",book:{id:"5934",slug:"selected-studies-in-biodiversity",title:"Selected Studies in Biodiversity",fullTitle:"Selected Studies in Biodiversity"},signatures:"Olga L. Kupika, Edson Gandiwa, Shakkie Kativu and Godwell\nNhamo",authors:[{id:"202318",title:"Ms.",name:"Olga Laiza",middleName:null,surname:"Kupika",slug:"olga-laiza-kupika",fullName:"Olga Laiza Kupika"},{id:"202328",title:"Prof.",name:"Edson",middleName:null,surname:"Gandiwa",slug:"edson-gandiwa",fullName:"Edson Gandiwa"},{id:"202330",title:"Prof.",name:"Shakkie",middleName:null,surname:"Kativu",slug:"shakkie-kativu",fullName:"Shakkie Kativu"},{id:"202334",title:"Prof.",name:"Godwell",middleName:null,surname:"Nhamo",slug:"godwell-nhamo",fullName:"Godwell Nhamo"}]},{id:"57718",title:"Methods for Biodiversity Assessment: Case Study in an Area of Atlantic Forest in Southern Brazil",slug:"methods-for-biodiversity-assessment-case-study-in-an-area-of-atlantic-forest-in-southern-brazil",totalDownloads:2819,totalCrossrefCites:2,totalDimensionsCites:8,abstract:"Populations and species are disappearing due to disturbances in the environment caused by human activities. Given, the obvious risk of loss of diversity, it is increasingly necessary to take actions concerning preservation, in which safety features are necessary for measuring the variation of diversity in space and time. The aim of this study was to evaluate the structure and diversity in the arboreal component and natural regeneration in an area of Araucaria Forest in Southern Brazil. The vegetation sampling was performed by analyzing 180 subunits of 10 × 10 m, where all the arboreal individuals and natural regeneration were inventoried. Different alpha and beta indexes of diversity were calculated. The Margalef, Shannon, and the Beta indexes were underestimated, possibly influenced by the size of sample unit. Index Menhinick represented the diversity in a very real form, even in small sampling units. The indexes of Simpson and MacIntosh denote low dominance and the equity indexes showed high uniformity in species.",book:{id:"5934",slug:"selected-studies-in-biodiversity",title:"Selected Studies in Biodiversity",fullTitle:"Selected Studies in Biodiversity"},signatures:"Maria Raquel Kanieski, Solon Jonas Longhi and Philipe Ricardo\nCasemiro Soares",authors:[{id:"219216",title:"Dr.",name:"Maria Raquel",middleName:null,surname:"Kanieski",slug:"maria-raquel-kanieski",fullName:"Maria Raquel Kanieski"},{id:"220250",title:"Dr.",name:"Solon Jonas",middleName:null,surname:"Longhi",slug:"solon-jonas-longhi",fullName:"Solon Jonas Longhi"},{id:"220251",title:"Dr.",name:"Philipe Ricardo",middleName:null,surname:"Casemiro Soares",slug:"philipe-ricardo-casemiro-soares",fullName:"Philipe Ricardo Casemiro Soares"}]},{id:"46541",title:"Ecosystem Biodiversity of India",slug:"ecosystem-biodiversity-of-india",totalDownloads:3480,totalCrossrefCites:1,totalDimensionsCites:4,abstract:null,book:{id:"3821",slug:"biodiversity-the-dynamic-balance-of-the-planet",title:"Biodiversity",fullTitle:"Biodiversity - The Dynamic Balance of the Planet"},signatures:"Vivek Khandekar and Anita Srivastava",authors:[{id:"51372",title:"Dr.",name:"Anita",middleName:null,surname:"Srivastava",slug:"anita-srivastava",fullName:"Anita Srivastava"},{id:"170148",title:"Dr.",name:"Vivek",middleName:null,surname:"Khandekar",slug:"vivek-khandekar",fullName:"Vivek Khandekar"}]},{id:"38697",title:"Floral and Avifaunal Diversity of Thol Lake Wildlife (Bird) Sanctuary of Gujarat State, India",slug:"floral-and-avifaunal-diversity-of-thol-lake-wildlife-bird-sanctuary-of-gujarat-state-india",totalDownloads:4009,totalCrossrefCites:0,totalDimensionsCites:0,abstract:null,book:{id:"2719",slug:"biodiversity-enrichment-in-a-diverse-world",title:"Biodiversity Enrichment in a Diverse World",fullTitle:"Biodiversity Enrichment in a Diverse World"},signatures:"Jessica P. Karia",authors:[{id:"142623",title:"Dr.",name:"Jessica",middleName:null,surname:"Karia",slug:"jessica-karia",fullName:"Jessica Karia"}]},{id:"38612",title:"Soil Fauna Diversity - Function, Soil Degradation, Biological Indices, Soil Restoration",slug:"soil-fauna-diversity-function-soil-degradation-biological-indices-soil-restoration",totalDownloads:7783,totalCrossrefCites:27,totalDimensionsCites:59,abstract:null,book:{id:"3007",slug:"biodiversity-conservation-and-utilization-in-a-diverse-world",title:"Biodiversity Conservation and Utilization in a Diverse World",fullTitle:"Biodiversity Conservation and Utilization in a Diverse World"},signatures:"Cristina Menta",authors:[{id:"145410",title:"PhD.",name:"Cristina",middleName:null,surname:"Menta",slug:"cristina-menta",fullName:"Cristina Menta"}]}],onlineFirstChaptersFilter:{topicId:"841",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"82587",title:"Introductory Chapter: Factors That Affect Biodiversity and Species Richness of Ecosystems - A Review",slug:"introductory-chapter-factors-that-affect-biodiversity-and-species-richness-of-ecosystems-a-review",totalDownloads:15,totalDimensionsCites:0,doi:"10.5772/intechopen.105890",abstract:null,book:{id:"10763",title:"Biodiversity of Ecosystems",coverURL:"https://cdn.intechopen.com/books/images_new/10763.jpg"},signatures:"Levente Hufnagel and Ferenc Mics"},{id:"81863",title:"Exploiting the Attributes of Biocontrol Agent (Neochetina bruchi) as a Potential Ecosystem Engineer’s",slug:"exploiting-the-attributes-of-biocontrol-agent-neochetina-bruchi-as-a-potential-ecosystem-engineer-s",totalDownloads:7,totalDimensionsCites:0,doi:"10.5772/intechopen.104775",abstract:"The biodiversity of lakes is continuously declining and diverse communities are being substituted by monoculture of invasive Eichhornia crassipes, resulting in a slew of environmental cascade effects. The ability of the Neochetina bruchi to self-perpetuate is a desirable aspect of biological control since it decreases the population to a reasonable level, making the approach more sustainable. N. bruchi is often referred to as “ecological engineers” because of the number of services it provides to the environment and enables herbicide application to be substantially reduced. Despite the presence of highly effective weevils against this weed, its effect on water hyacinth in association with the nutrients present in sites, is likely to vary with levels of disturbance caused by natural and anthropogenic factors. Understanding the aspects that determine the performance of these eco-engineers as valuable management tools will help to guide future endeavors. Our objective is to better comprehend their utility and limitations, along with critical knowledge gaps, to further enhance future applications.",book:{id:"10763",title:"Biodiversity of Ecosystems",coverURL:"https://cdn.intechopen.com/books/images_new/10763.jpg"},signatures:"Prerna Gupta and Sadhna Tamot"},{id:"80833",title:"Comparison of the Effectiveness of Different Tags in the Sea Urchin Paracentrotus lividus (Lamarck, 1816)",slug:"comparison-of-the-effectiveness-of-different-tags-in-the-sea-urchin-paracentrotus-lividus-lamarck-18",totalDownloads:58,totalDimensionsCites:0,doi:"10.5772/intechopen.102594",abstract:"The marking of sea urchins was implemented with the main objective of being able to individually identify the urchins in the natural environment once released. In addition, it’s very useful to monitor individuals in studies of growth, movements, development, population dynamics, etc., that develop in the natural environment. Numerous different marking methodologies have been tested for sea urchins, either by physical marking (external and internal labels) or by using chemical marking methods consisting of the use of fluorochromes, which adhere to the calcified structures of the urchin. In this work, 5 different physical marks were used to mark 400 urchins of the Paracentrotus lividus species, which were kept for a month at the ECIMAT facilities in Toralla island. The efficacy of the methods used in each case was analyzed, comparing the survival rate and the tag retention rate of the tagged urchins obtained with each tagging methodology.",book:{id:"10763",title:"Biodiversity of Ecosystems",coverURL:"https://cdn.intechopen.com/books/images_new/10763.jpg"},signatures:"Noelia Tourón, Estefanía Paredes and Damián Costas"},{id:"79769",title:"Elucidation of Some Ecological Traits of Carabids (Coleoptera: Carabidae) Inhabiting Kakuma Campus Grassland, Kanazawa City, Japan",slug:"elucidation-of-some-ecological-traits-of-carabids-coleoptera-carabidae-inhabiting-kakuma-campus-gras",totalDownloads:46,totalDimensionsCites:0,doi:"10.5772/intechopen.101658",abstract:"Although adult feeding habits and food requirements are currently and reasonably well known for many coleopteran species, still some carabid species are with peculiar feeding guilds. Although many studies have shown a relationship between morphology of mandibles and feeding behavior in different taxal group, still many aspects concerning the feeding behavior of carabids are promising. An assemblage of carabid species was collected from Kakuma Campus grassland in Kanazawa City, Japan. These species were represented by five subfamilies and nine tribes where the highest number of tribes (3 tribes) was confined to subfamily Harpalinae. The collected carabid assemblage was subjected to mandibular analysis and being categorized into two main groups; carnivorous and omnivorous species. Homologies among mandibular characteristics and functional adaptations of the mandible were also proposed to explore how the interaction network of carabids can affect their behavior in different habitats.",book:{id:"10763",title:"Biodiversity of Ecosystems",coverURL:"https://cdn.intechopen.com/books/images_new/10763.jpg"},signatures:"Shahenda Abu ElEla Ali Abu ElEla, Wael Mahmoud ElSayed and Nakamura Koji"},{id:"79313",title:"The Diversity of Endophytic Aspergillus",slug:"the-diversity-of-endophytic-aspergillus",totalDownloads:130,totalDimensionsCites:0,doi:"10.5772/intechopen.99717",abstract:"In plants, endophytic fungi and plant are closely related, endophytic fungi can use substances in plants as nutrients to survive. In return, they bring many benefits to the plant, playing an important role in protecting the host plant against the harmful effects of insects, harmful microorganisms or environmental disadvantages. Recently, secondary fungi metabolites, especially endophytic fungi, are gaining interest because they can produce many bioactive metabolites with antibacterial, anticancer and antioxidant properties. Some endophytic fungi are noted as Aspergillus, Penicllium, Fusarium due to the production of many metabolites for biological effects such as antibacterial, antiviral, anticancer, etc. in which Aspergillus species product many compounds have properties antibacterial such as terrequinon A, terrefuranon, Na-acetyl aszonalemin, etc.",book:{id:"10763",title:"Biodiversity of Ecosystems",coverURL:"https://cdn.intechopen.com/books/images_new/10763.jpg"},signatures:"Vo Thi Ngoc My and Nguyen Van Thanh"},{id:"79203",title:"Soil Biodiversity and Root Pathogens in Agroecosystems",slug:"soil-biodiversity-and-root-pathogens-in-agroecosystems",totalDownloads:157,totalDimensionsCites:0,doi:"10.5772/intechopen.99317",abstract:"Soil ecosystem is a living and dynamic environment, habitat of thousands of microbial species, animal organisms and plant roots, integrated all of them in the food webs, and performing vital functions like organic matter decomposition and nutrient cycling; soil is also where plant roots productivity represent the main and first trophic level (producers), the beginning of the soil food web and of thousands of biological interactions. Agroecosystems are modified ecosystems by man in which plant, animal and microorganisms biodiversity has been altered, and sometimes decreased to a minimum number of species. Plant diseases, including root diseases caused by soil-borne plant pathogens are important threats to crop yield and they causes relevant economic losses. Soil-borne plant pathogens and the diseases they produce can cause huge losses and even social and environmental changes, for instance the Irish famine caused by Phytophthora infestans (1845–1853), or the harmful ecological alterations in the jarrah forests of Western Australia affected by Phytophthora cinnamomi in the last 100 years. How can a root pathogen species increase its populations densities at epidemic levels? In wild ecosystems usually we expect the soil biodiversity (microbiome, nematodes, mycorrhiza, protozoa, worms, etc.) through the trophic webs and different interactions between soil species, are going to regulate each other and the pathogens populations, avoiding disease outbreaks. In agroecosystems where plant diseases and epidemics are frequent and destructive, soil-borne plant pathogens has been managed applying different strategies: chemical, cultural, biological agents and others; however so far, there is not enough knowledge about how important is soil biodiversity, mainly microbiome diversity and soil food webs structure and function in the management of root pathogens, in root and plant health, in healthy food production, and maybe more relevant in the conservation of soil as a natural resource and derived from it, the ecosystem services important for life in our planet.",book:{id:"10763",title:"Biodiversity of Ecosystems",coverURL:"https://cdn.intechopen.com/books/images_new/10763.jpg"},signatures:"María del Pilar Rodríguez Guzmán"}],onlineFirstChaptersTotal:12},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:139,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:122,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:21,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:10,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"24",title:"Sustainable Development",doi:"10.5772/intechopen.100361",issn:"2753-6580",scope:"
\r\n\tTransforming our World: the 2030 Agenda for Sustainable Development endorsed by United Nations and 193 Member States, came into effect on Jan 1, 2016, to guide decision making and actions to the year 2030 and beyond. Central to this Agenda are 17 Goals, 169 associated targets and over 230 indicators that are reviewed annually. The vision envisaged in the implementation of the SDGs is centered on the five Ps: People, Planet, Prosperity, Peace and Partnership. This call for renewed focused efforts ensure we have a safe and healthy planet for current and future generations.
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\r\n\tThis Series focuses on covering research and applied research involving the five Ps through the following topics:
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\r\n\t1. Sustainable Economy and Fair Society that relates to SDG 1 on No Poverty, SDG 2 on Zero Hunger, SDG 8 on Decent Work and Economic Growth, SDG 10 on Reduced Inequalities, SDG 12 on Responsible Consumption and Production, and SDG 17 Partnership for the Goals
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\r\n\t2. Health and Wellbeing focusing on SDG 3 on Good Health and Wellbeing and SDG 6 on Clean Water and Sanitation
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\r\n\t3. Inclusivity and Social Equality involving SDG 4 on Quality Education, SDG 5 on Gender Equality, and SDG 16 on Peace, Justice and Strong Institutions
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\r\n\t4. Climate Change and Environmental Sustainability comprising SDG 13 on Climate Action, SDG 14 on Life Below Water, and SDG 15 on Life on Land
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\r\n\t5. Urban Planning and Environmental Management embracing SDG 7 on Affordable Clean Energy, SDG 9 on Industry, Innovation and Infrastructure, and SDG 11 on Sustainable Cities and Communities.
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\r\n\tThe series also seeks to support the use of cross cutting SDGs, as many of the goals listed above, targets and indicators are all interconnected to impact our lives and the decisions we make on a daily basis, making them impossible to tie to a single topic.
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Radiotherapy and Nuclear Medicine Technology has always been my aspiration and my life. As years passed I accumulated a tremendous amount of skills and knowledge in Radiotherapy and Nuclear Medicine, Conventional Radiology, Radiation Protection, Bioinformatics Technology, PACS, Image processing, clinically and lecturing that will enable me to provide a valuable service to the community as a Researcher and Consultant in this field. 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In subsequent years, the concept of 'telematic education” subsequently becomes well established in academic circles in South Africa, grew in popularity, and is adopted by many universities and colleges throughout South Africa as a medium of enhancing education and training, as a method to reaching out to far out communities, and as a means to enhance study from the home environment.\r\n\r\nProfessor Snyman in subsequent years pursued research in semiconductor physics, semiconductor devices, microelectronics, and optoelectronics.\r\n\r\nIn 2000 he joined the TUT as a full professor. Here served for a period as head of the Department of Electronic Engineering. Here he makes contributions to solar energy development, microwave and optoelectronic device development, silicon photonics, as well as contributions to new mobile telecommunication systems and network planning in SA.\r\n\r\nCurrently, he teaches electronics and telecommunications at the TUT to audiences ranging from first-year students to Ph.D. level.\r\n\r\nFor his research in the field of 'Silicon Photonics” since 1990, he has published (as author and co-author) about thirty internationally reviewed articles in scientific journals, contributed to more than forty international conferences, about 25 South African provisional patents (as inventor and co-inventor), 8 PCT international patent applications until now. Of these, two USA patents applications, two European Patents, two Korean patents, and ten SA patents have been granted. A further 4 USA patents, 5 European patents, 3 Korean patents, 3 Chinese patents, and 3 Japanese patents are currently under consideration.\r\n\r\nRecently he has also published an extensive scholarly chapter in an internet open access book on 'Integrating Microphotonic Systems and MOEMS into standard Silicon CMOS Integrated circuitry”.\r\n\r\nFurthermore, Professor Snyman recently steered a new initiative at the TUT by introducing a 'Laboratory for Innovative Electronic Systems ' at the Department of Electrical Engineering. The model of this laboratory or center is to primarily combine outputs as achieved by high-level research with lower-level system development and entrepreneurship in a technical university environment. Students are allocated to projects at different levels with PhDs and Master students allocated to the generation of new knowledge and new technologies, while students at the diploma and Baccalaureus level are allocated to electronic systems development with a direct and a near application for application in industry or the commercial and public sectors in South Africa.\r\n\r\nProfessor Snyman received the WIRSAM Award of 1983 and the WIRSAM Award in 1985 in South Africa for best research papers by a young scientist at two international conferences on electron microscopy in South Africa. He subsequently received the SA Microelectronics Award for the best dissertation emanating from studies executed at a South African university in the field of Physics and Microelectronics in South Africa in 1987. In October of 2011, Professor Snyman received the prestigious Institutional Award for 'Innovator of the Year” for 2010 at the Tshwane University of Technology, South Africa. This award was based on the number of patents recognized and granted by local and international institutions as well as for his contributions concerning innovation at the TUT.",institutionString:null,institution:{name:"University of South Africa",country:{name:"South Africa"}}},{id:"317279",title:"Mr.",name:"Ali",middleName:"Usama",surname:"Syed",slug:"ali-syed",fullName:"Ali Syed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/317279/images/16024_n.png",biography:"A creative, talented, and innovative young professional who is dedicated, well organized, and capable research fellow with two years of experience in graduate-level research, published in engineering journals and book, with related expertise in Bio-robotics, equally passionate about the aesthetics of the mechanical and electronic system, obtained expertise in the use of MS Office, MATLAB, SolidWorks, LabVIEW, Proteus, Fusion 360, having a grasp on python, C++ and assembly language, possess proven ability in acquiring research grants, previous appointments with social and educational societies with experience in administration, current affiliations with IEEE and Web of Science, a confident presenter at conferences and teacher in classrooms, able to explain complex information to audiences of all levels.",institutionString:null,institution:{name:"Air University",country:{name:"Pakistan"}}},{id:"75526",title:"Ph.D.",name:"Zihni Onur",middleName:null,surname:"Uygun",slug:"zihni-onur-uygun",fullName:"Zihni Onur Uygun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/75526/images/12_n.jpg",biography:"My undergraduate education and my Master of Science educations at Ege University and at Çanakkale Onsekiz Mart University have given me a firm foundation in Biochemistry, Analytical Chemistry, Biosensors, Bioelectronics, Physical Chemistry and Medicine. After obtaining my degree as a MSc in analytical chemistry, I started working as a research assistant in Ege University Medical Faculty in 2014. In parallel, I enrolled to the MSc program at the Department of Medical Biochemistry at Ege University to gain deeper knowledge on medical and biochemical sciences as well as clinical chemistry in 2014. In my PhD I deeply researched on biosensors and bioelectronics and finished in 2020. Now I have eleven SCI-Expanded Index published papers, 6 international book chapters, referee assignments for different SCIE journals, one international patent pending, several international awards, projects and bursaries. In parallel to my research assistant position at Ege University Medical Faculty, Department of Medical Biochemistry, in April 2016, I also founded a Start-Up Company (Denosens Biotechnology LTD) by the support of The Scientific and Technological Research Council of Turkey. Currently, I am also working as a CEO in Denosens Biotechnology. The main purposes of the company, which carries out R&D as a research center, are to develop new generation biosensors and sensors for both point-of-care diagnostics; such as glucose, lactate, cholesterol and cancer biomarker detections. My specific experimental and instrumental skills are Biochemistry, Biosensor, Analytical Chemistry, Electrochemistry, Mobile phone based point-of-care diagnostic device, POCTs and Patient interface designs, HPLC, Tandem Mass Spectrometry, Spectrophotometry, ELISA.",institutionString:null,institution:{name:"Ege University",country:{name:"Turkey"}}},{id:"267434",title:"Dr.",name:"Rohit",middleName:null,surname:"Raja",slug:"rohit-raja",fullName:"Rohit Raja",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/267434/images/system/267434.jpg",biography:"Dr. Rohit Raja received Ph.D. in Computer Science and Engineering from Dr. CVRAMAN University in 2016. His main research interest includes Face recognition and Identification, Digital Image Processing, Signal Processing, and Networking. Presently he is working as Associate Professor in IT Department, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur (CG), India. He has authored several Journal and Conference Papers. He has good Academics & Research experience in various areas of CSE and IT. He has filed and successfully published 27 Patents. He has received many time invitations to be a Guest at IEEE Conferences. He has published 100 research papers in various International/National Journals (including IEEE, Springer, etc.) and Proceedings of the reputed International/ National Conferences (including Springer and IEEE). He has been nominated to the board of editors/reviewers of many peer-reviewed and refereed Journals (including IEEE, Springer).",institutionString:"Guru Ghasidas Vishwavidyalaya",institution:{name:"Guru Ghasidas Vishwavidyalaya",country:{name:"India"}}},{id:"246502",title:"Dr.",name:"Jaya T.",middleName:"T",surname:"Varkey",slug:"jaya-t.-varkey",fullName:"Jaya T. Varkey",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246502/images/11160_n.jpg",biography:"Jaya T. Varkey, PhD, graduated with a degree in Chemistry from Cochin University of Science and Technology, Kerala, India. She obtained a PhD in Chemistry from the School of Chemical Sciences, Mahatma Gandhi University, Kerala, India, and completed a post-doctoral fellowship at the University of Minnesota, USA. She is a research guide at Mahatma Gandhi University and Associate Professor in Chemistry, St. Teresa’s College, Kochi, Kerala, India.\nDr. Varkey received a National Young Scientist award from the Indian Science Congress (1995), a UGC Research award (2016–2018), an Indian National Science Academy (INSA) Visiting Scientist award (2018–2019), and a Best Innovative Faculty award from the All India Association for Christian Higher Education (AIACHE) (2019). She Hashas received the Sr. Mary Cecil prize for best research paper three times. She was also awarded a start-up to develop a tea bag water filter. \nDr. Varkey has published two international books and twenty-seven international journal publications. She is an editorial board member for five international journals.",institutionString:"St. Teresa’s College",institution:null},{id:"250668",title:"Dr.",name:"Ali",middleName:null,surname:"Nabipour Chakoli",slug:"ali-nabipour-chakoli",fullName:"Ali Nabipour Chakoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/250668/images/system/250668.jpg",biography:"Academic Qualification:\r\n•\tPhD in Materials Physics and Chemistry, From: Sep. 2006, to: Sep. 2010, School of Materials Science and Engineering, Harbin Institute of Technology, Thesis: Structure and Shape Memory Effect of Functionalized MWCNTs/poly (L-lactide-co-ε-caprolactone) Nanocomposites. Supervisor: Prof. Wei Cai,\r\n•\tM.Sc in Applied Physics, From: 1996, to: 1998, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Determination of Boron in Micro alloy Steels with solid state nuclear track detectors by neutron induced auto radiography, Supervisors: Dr. M. Hosseini Ashrafi and Dr. A. Hosseini.\r\n•\tB.Sc. in Applied Physics, From: 1991, to: 1996, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Design of shielding for Am-Be neutron sources for In Vivo neutron activation analysis, Supervisor: Dr. M. Hosseini Ashrafi.\r\n\r\nResearch Experiences:\r\n1.\tNanomaterials, Carbon Nanotubes, Graphene: Synthesis, Functionalization and Characterization,\r\n2.\tMWCNTs/Polymer Composites: Fabrication and Characterization, \r\n3.\tShape Memory Polymers, Biodegradable Polymers, ORC, Collagen,\r\n4.\tMaterials Analysis and Characterizations: TEM, SEM, XPS, FT-IR, Raman, DSC, DMA, TGA, XRD, GPC, Fluoroscopy, \r\n5.\tInteraction of Radiation with Mater, Nuclear Safety and Security, NDT(RT),\r\n6.\tRadiation Detectors, Calibration (SSDL),\r\n7.\tCompleted IAEA e-learning Courses:\r\nNuclear Security (15 Modules),\r\nNuclear Safety:\r\nTSA 2: Regulatory Protection in Occupational Exposure,\r\nTips & Tricks: Radiation Protection in Radiography,\r\nSafety and Quality in Radiotherapy,\r\nCourse on Sealed Radioactive Sources,\r\nCourse on Fundamentals of Environmental Remediation,\r\nCourse on Planning for Environmental Remediation,\r\nKnowledge Management Orientation Course,\r\nFood Irradiation - Technology, Applications and Good Practices,\r\nEmployment:\r\nFrom 2010 to now: Academic staff, Nuclear Science and Technology Research Institute, Kargar Shomali, Tehran, Iran, P.O. Box: 14395-836.\r\nFrom 1997 to 2006: Expert of Materials Analysis and Characterization. Research Center of Agriculture and Medicine. Rajaeeshahr, Karaj, Iran, P. O. Box: 31585-498.",institutionString:"Atomic Energy Organization of Iran",institution:{name:"Atomic Energy Organization of Iran",country:{name:"Iran"}}},{id:"248279",title:"Dr.",name:"Monika",middleName:"Elzbieta",surname:"Machoy",slug:"monika-machoy",fullName:"Monika Machoy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248279/images/system/248279.jpeg",biography:"Monika Elżbieta Machoy, MD, graduated with distinction from the Faculty of Medicine and Dentistry at the Pomeranian Medical University in 2009, defended her PhD thesis with summa cum laude in 2016 and is currently employed as a researcher at the Department of Orthodontics of the Pomeranian Medical University. She expanded her professional knowledge during a one-year scholarship program at the Ernst Moritz Arndt University in Greifswald, Germany and during a three-year internship at the Technical University in Dresden, Germany. She has been a speaker at numerous orthodontic conferences, among others, American Association of Orthodontics, European Orthodontic Symposium and numerous conferences of the Polish Orthodontic Society. She conducts research focusing on the effect of orthodontic treatment on dental and periodontal tissues and the causes of pain in orthodontic patients.",institutionString:"Pomeranian Medical University",institution:{name:"Pomeranian Medical University",country:{name:"Poland"}}},{id:"252743",title:"Prof.",name:"Aswini",middleName:"Kumar",surname:"Kar",slug:"aswini-kar",fullName:"Aswini Kar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252743/images/10381_n.jpg",biography:"uploaded in cv",institutionString:null,institution:{name:"KIIT University",country:{name:"India"}}},{id:"204256",title:"Dr.",name:"Anil",middleName:"Kumar",surname:"Kumar Sahu",slug:"anil-kumar-sahu",fullName:"Anil Kumar Sahu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204256/images/14201_n.jpg",biography:"I have nearly 11 years of research and teaching experience. I have done my master degree from University Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur, Chhattisgarh India. I have published 16 review and research articles in international and national journals and published 4 chapters in IntechOpen, the world’s leading publisher of Open access books. I have presented many papers at national and international conferences. I have received research award from Indian Drug Manufacturers Association in year 2015. My research interest extends from novel lymphatic drug delivery systems, oral delivery system for herbal bioactive to formulation optimization.",institutionString:null,institution:{name:"Chhattisgarh Swami Vivekanand Technical University",country:{name:"India"}}},{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",biography:"An assistant professor at Department of Biomedical Computer Systems, at Institute of Computer Science, Silesian University in Katowice. Scientific interests: computer analysis and processing of images, biomedical images, databases and programming languages. He is an author and co-author of scientific publications covering analysis and processing of biomedical images and development of database systems.",institutionString:"University of Silesia",institution:{name:"University of Silesia",country:{name:"Poland"}}},{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",biography:"Dr. Hadi Mohammadi is a biomedical engineer with hands-on experience in the design and development of many engineering structures and medical devices through various projects that he has been involved in over the past twenty years. Dr. Mohammadi received his BSc. and MSc. degrees in Mechanical Engineering from Sharif University of Technology, Tehran, Iran, and his PhD. degree in Biomedical Engineering (biomaterials) from the University of Western Ontario. He was a postdoctoral trainee for almost four years at University of Calgary and Harvard Medical School. He is an industry innovator having created the technology to produce lifelike synthetic platforms that can be used for the simulation of almost all cardiovascular reconstructive surgeries. He’s been heavily involved in the design and development of cardiovascular devices and technology for the past 10 years. He is currently an Assistant Professor with the University of British Colombia, Canada.",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",country:{name:"Canada"}}},{id:"254463",title:"Prof.",name:"Haisheng",middleName:null,surname:"Yang",slug:"haisheng-yang",fullName:"Haisheng Yang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/254463/images/system/254463.jpeg",biography:"Haisheng Yang, Ph.D., Professor and Director of the Department of Biomedical Engineering, College of Life Science and Bioengineering, Beijing University of Technology. He received his Ph.D. degree in Mechanics/Biomechanics from Harbin Institute of Technology (jointly with University of California, Berkeley). Afterwards, he worked as a Postdoctoral Research Associate in the Purdue Musculoskeletal Biology and Mechanics Lab at the Department of Basic Medical Sciences, Purdue University, USA. He also conducted research in the Research Centre of Shriners Hospitals for Children-Canada at McGill University, Canada. Dr. Yang has over 10 years research experience in orthopaedic biomechanics and mechanobiology of bone adaptation and regeneration. He earned an award from Beijing Overseas Talents Aggregation program in 2017 and serves as Beijing Distinguished Professor.",institutionString:null,institution:{name:"Beijing University of Technology",country:{name:"China"}}},{id:"89721",title:"Dr.",name:"Mehmet",middleName:"Cuneyt",surname:"Ozmen",slug:"mehmet-ozmen",fullName:"Mehmet Ozmen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/89721/images/7289_n.jpg",biography:null,institutionString:null,institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"265335",title:"Mr.",name:"Stefan",middleName:"Radnev",surname:"Stefanov",slug:"stefan-stefanov",fullName:"Stefan Stefanov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/265335/images/7562_n.jpg",biography:null,institutionString:null,institution:{name:"Medical University Plovdiv",country:{name:"Bulgaria"}}},{id:"242893",title:"Ph.D. Student",name:"Joaquim",middleName:null,surname:"De Moura",slug:"joaquim-de-moura",fullName:"Joaquim De Moura",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/242893/images/7133_n.jpg",biography:"Joaquim de Moura received his degree in Computer Engineering in 2014 from the University of A Coruña (Spain). In 2016, he received his M.Sc degree in Computer Engineering from the same university. He is currently pursuing his Ph.D degree in Computer Science in a collaborative project between ophthalmology centers in Galicia and the University of A Coruña. His research interests include computer vision, machine learning algorithms and analysis and medical imaging processing of various kinds.",institutionString:null,institution:{name:"University of A Coruña",country:{name:"Spain"}}},{id:"294334",title:"B.Sc.",name:"Marc",middleName:null,surname:"Bruggeman",slug:"marc-bruggeman",fullName:"Marc Bruggeman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/294334/images/8242_n.jpg",biography:"Chemical engineer graduate, with a passion for material science and specific interest in polymers - their near infinite applications intrigue me. \n\nI plan to continue my scientific career in the field of polymeric biomaterials as I am fascinated by intelligent, bioactive and biomimetic materials for use in both consumer and medical applications.",institutionString:null,institution:null},{id:"255757",title:"Dr.",name:"Igor",middleName:"Victorovich",surname:"Lakhno",slug:"igor-lakhno",fullName:"Igor Lakhno",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255757/images/system/255757.jpg",biography:"Igor Victorovich Lakhno was born in 1971 in Kharkiv (Ukraine). \nMD – 1994, Kharkiv National Medical Univesity.\nOb&Gyn; – 1997, master courses in Kharkiv Medical Academy of Postgraduate Education.\nPh.D. – 1999, Kharkiv National Medical Univesity.\nDSC – 2019, PL Shupik National Academy of Postgraduate Education \nProfessor – 2021, Department of Obstetrics and Gynecology of VN Karazin Kharkiv National University\nHead of Department – 2021, Department of Perinatology, Obstetrics and gynecology of Kharkiv Medical Academy of Postgraduate Education\nIgor Lakhno has been graduated from international training courses on reproductive medicine and family planning held at Debrecen University (Hungary) in 1997. Since 1998 Lakhno Igor has worked as an associate professor in the department of obstetrics and gynecology of VN Karazin National University and an associate professor of the perinatology, obstetrics, and gynecology department of Kharkiv Medical Academy of Postgraduate Education. Since June 2019 he’s been a professor in the department of obstetrics and gynecology of VN Karazin National University and a professor of the perinatology, obstetrics, and gynecology department. He’s affiliated with Kharkiv Medical Academy of Postgraduate Education as a Head of Department from November 2021. Igor Lakhno has participated in several international projects on fetal non-invasive electrocardiography (with Dr. J. A. Behar (Technion), Prof. D. Hoyer (Jena University), and José Alejandro Díaz Méndez (National Institute of Astrophysics, Optics, and Electronics, Mexico). He’s an author of about 200 printed works and there are 31 of them in Scopus or Web of Science databases. Igor Lakhno is a member of the Editorial Board of Reproductive Health of Woman, Emergency Medicine, and Technology Transfer Innovative Solutions in Medicine (Estonia). He is a medical Editor of “Z turbotoyu pro zhinku”. Igor Lakhno is a reviewer of the Journal of Obstetrics and Gynaecology (Taylor and Francis), British Journal of Obstetrics and Gynecology (Wiley), Informatics in Medicine Unlocked (Elsevier), The Journal of Obstetrics and Gynecology Research (Wiley), Endocrine, Metabolic & Immune Disorders-Drug Targets (Bentham Open), The Open Biomedical Engineering Journal (Bentham Open), etc. He’s defended a dissertation for a DSc degree “Pre-eclampsia: prediction, prevention, and treatment”. Three years ago Igor Lakhno has participated in a training course on innovative technologies in medical education at Lublin Medical University (Poland). Lakhno Igor has participated as a speaker in several international conferences and congresses (International Conference on Biological Oscillations April 10th-14th 2016, Lancaster, UK, The 9th conference of the European Study Group on Cardiovascular Oscillations). His main scientific interests: are obstetrics, women’s health, fetal medicine, and cardiovascular medicine. \nIgor Lakhno is a consultant at Kharkiv municipal perinatal center. He’s graduated from training courses on endoscopy in gynecology. He has 28 years of practical experience in the field.",institutionString:null,institution:null},{id:"244950",title:"Dr.",name:"Salvatore",middleName:null,surname:"Di Lauro",slug:"salvatore-di-lauro",fullName:"Salvatore Di Lauro",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0030O00002bSF1HQAW/ProfilePicture%202021-12-20%2014%3A54%3A14.482",biography:"Name:\n\tSALVATORE DI LAURO\nAddress:\n\tHospital Clínico Universitario Valladolid\nAvda Ramón y Cajal 3\n47005, Valladolid\nSpain\nPhone number: \nFax\nE-mail:\n\t+34 983420000 ext 292\n+34 983420084\nsadilauro@live.it\nDate and place of Birth:\nID Number\nMedical Licence \nLanguages\t09-05-1985. Villaricca (Italy)\n\nY1281863H\n474707061\nItalian (native language)\nSpanish (read, written, spoken)\nEnglish (read, written, spoken)\nPortuguese (read, spoken)\nFrench (read)\n\t\t\nCurrent position (title and company)\tDate (Year)\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. Private practise.\t2017-today\n\n2019-today\n\t\n\t\nEducation (High school, university and postgraduate training > 3 months)\tDate (Year)\nDegree in Medicine and Surgery. University of Neaples 'Federico II”\nResident in Opthalmology. Hospital Clinico Universitario Valladolid\nMaster in Vitreo-Retina. IOBA. University of Valladolid\nFellow of the European Board of Ophthalmology. Paris\nMaster in Research in Ophthalmology. University of Valladolid\t2003-2009\n2012-2016\n2016-2017\n2016\n2012-2013\n\t\nEmployments (company and positions)\tDate (Year)\nResident in Ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl.\nFellow in Vitreo-Retina. IOBA. University of Valladolid\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. \n\t2012-2016\n2016-2017\n2017-today\n\n2019-Today\n\n\n\t\nClinical Research Experience (tasks and role)\tDate (Year)\nAssociated investigator\n\n' FIS PI20/00740: DESARROLLO DE UNA CALCULADORA DE RIESGO DE\nAPARICION DE RETINOPATIA DIABETICA BASADA EN TECNICAS DE IMAGEN MULTIMODAL EN PACIENTES DIABETICOS TIPO 1. Grant by: Ministerio de Ciencia e Innovacion \n\n' (BIO/VA23/14) Estudio clínico multicéntrico y prospectivo para validar dos\nbiomarcadores ubicados en los genes p53 y MDM2 en la predicción de los resultados funcionales de la cirugía del desprendimiento de retina regmatógeno. Grant by: Gerencia Regional de Salud de la Junta de Castilla y León.\n' Estudio multicéntrico, aleatorizado, con enmascaramiento doble, en 2 grupos\nparalelos y de 52 semanas de duración para comparar la eficacia, seguridad e inmunogenicidad de SOK583A1 respecto a Eylea® en pacientes con degeneración macular neovascular asociada a la edad' (CSOK583A12301; N.EUDRA: 2019-004838-41; FASE III). Grant by Hexal AG\n\n' Estudio de fase III, aleatorizado, doble ciego, con grupos paralelos, multicéntrico para comparar la eficacia y la seguridad de QL1205 frente a Lucentis® en pacientes con degeneración macular neovascular asociada a la edad. (EUDRACT: 2018-004486-13). Grant by Qilu Pharmaceutical Co\n\n' Estudio NEUTON: Ensayo clinico en fase IV para evaluar la eficacia de aflibercept en pacientes Naive con Edema MacUlar secundario a Oclusion de Vena CenTral de la Retina (OVCR) en regimen de tratamientO iNdividualizado Treat and Extend (TAE)”, (2014-000975-21). Grant by Fundacion Retinaplus\n\n' Evaluación de la seguridad y bioactividad de anillos de tensión capsular en conejo. Proyecto Procusens. Grant by AJL, S.A.\n\n'Estudio epidemiológico, prospectivo, multicéntrico y abierto\\npara valorar la frecuencia de la conjuntivitis adenovírica diagnosticada mediante el test AdenoPlus®\\nTest en pacientes enfermos de conjuntivitis aguda”\\n. National, multicenter study. Grant by: NICOX.\n\nEuropean multicentric trial: 'Evaluation of clinical outcomes following the use of Systane Hydration in patients with dry eye”. Study Phase 4. Grant by: Alcon Labs'\n\nVLPs Injection and Activation in a Rabbit Model of Uveal Melanoma. Grant by Aura Bioscience\n\nUpdating and characterization of a rabbit model of uveal melanoma. Grant by Aura Bioscience\n\nEnsayo clínico en fase IV para evaluar las variantes genéticas de la vía del VEGF como biomarcadores de eficacia del tratamiento con aflibercept en pacientes con degeneración macular asociada a la edad (DMAE) neovascular. Estudio BIOIMAGE. IMO-AFLI-2013-01\n\nEstudio In-Eye:Ensayo clínico en fase IV, abierto, aleatorizado, de 2 brazos,\nmulticçentrico y de 12 meses de duración, para evaluar la eficacia y seguridad de un régimen de PRN flexible individualizado de 'esperar y extender' versus un régimen PRN según criterios de estabilización mediante evaluaciones mensuales de inyecciones intravítreas de ranibizumab 0,5 mg en pacientes naive con neovascularización coriodea secunaria a la degeneración macular relacionada con la edad. CP: CRFB002AES03T\n\nTREND: Estudio Fase IIIb multicéntrico, randomizado, de 12 meses de\nseguimiento con evaluador de la agudeza visual enmascarado, para evaluar la eficacia y la seguridad de ranibizumab 0.5mg en un régimen de tratar y extender comparado con un régimen mensual, en pacientes con degeneración macular neovascular asociada a la edad. CP: CRFB002A2411 Código Eudra CT:\n2013-002626-23\n\n\n\nPublications\t\n\n2021\n\n\n\n\n2015\n\n\n\n\n2021\n\n\n\n\n\n2021\n\n\n\n\n2015\n\n\n\n\n2015\n\n\n2014\n\n\n\n\n2015-16\n\n\n\n2015\n\n\n2014\n\n\n2014\n\n\n\n\n2014\n\n\n\n\n\n\n\n2014\n\nJose Carlos Pastor; Jimena Rojas; Salvador Pastor-Idoate; Salvatore Di Lauro; Lucia Gonzalez-Buendia; Santiago Delgado-Tirado. Proliferative vitreoretinopathy: A new concept of disease pathogenesis and practical\nconsequences. Progress in Retinal and Eye Research. 51, pp. 125 - 155. 03/2016. DOI: 10.1016/j.preteyeres.2015.07.005\n\n\nLabrador-Velandia S; Alonso-Alonso ML; Di Lauro S; García-Gutierrez MT; Srivastava GK; Pastor JC; Fernandez-Bueno I. Mesenchymal stem cells provide paracrine neuroprotective resources that delay degeneration of co-cultured organotypic neuroretinal cultures.Experimental Eye Research. 185, 17/05/2019. DOI: 10.1016/j.exer.2019.05.011\n\nSalvatore Di Lauro; Maria Teresa Garcia Gutierrez; Ivan Fernandez Bueno. Quantification of pigment epithelium-derived factor (PEDF) in an ex vivo coculture of retinal pigment epithelium cells and neuroretina.\nJournal of Allbiosolution. 2019. ISSN 2605-3535\n\nSonia Labrador Velandia; Salvatore Di Lauro; Alonso-Alonso ML; Tabera Bartolomé S; Srivastava GK; Pastor JC; Fernandez-Bueno I. Biocompatibility of intravitreal injection of human mesenchymal stem cells in immunocompetent rabbits. Graefe's archive for clinical and experimental ophthalmology. 256 - 1, pp. 125 - 134. 01/2018. DOI: 10.1007/s00417-017-3842-3\n\n\nSalvatore Di Lauro, David Rodriguez-Crespo, Manuel J Gayoso, Maria T Garcia-Gutierrez, J Carlos Pastor, Girish K Srivastava, Ivan Fernandez-Bueno. A novel coculture model of porcine central neuroretina explants and retinal pigment epithelium cells. Molecular Vision. 2016 - 22, pp. 243 - 253. 01/2016.\n\nSalvatore Di Lauro. Classifications for Proliferative Vitreoretinopathy ({PVR}): An Analysis of Their Use in Publications over the Last 15 Years. Journal of Ophthalmology. 2016, pp. 1 - 6. 01/2016. DOI: 10.1155/2016/7807596\n\nSalvatore Di Lauro; Rosa Maria Coco; Rosa Maria Sanabria; Enrique Rodriguez de la Rua; Jose Carlos Pastor. Loss of Visual Acuity after Successful Surgery for Macula-On Rhegmatogenous Retinal Detachment in a Prospective Multicentre Study. Journal of Ophthalmology. 2015:821864, 2015. DOI: 10.1155/2015/821864\n\nIvan Fernandez-Bueno; Salvatore Di Lauro; Ivan Alvarez; Jose Carlos Lopez; Maria Teresa Garcia-Gutierrez; Itziar Fernandez; Eva Larra; Jose Carlos Pastor. Safety and Biocompatibility of a New High-Density Polyethylene-Based\nSpherical Integrated Porous Orbital Implant: An Experimental Study in Rabbits. Journal of Ophthalmology. 2015:904096, 2015. DOI: 10.1155/2015/904096\n\nPastor JC; Pastor-Idoate S; Rodríguez-Hernandez I; Rojas J; Fernandez I; Gonzalez-Buendia L; Di Lauro S; Gonzalez-Sarmiento R. Genetics of PVR and RD. Ophthalmologica. 232 - Suppl 1, pp. 28 - 29. 2014\n\nRodriguez-Crespo D; Di Lauro S; Singh AK; Garcia-Gutierrez MT; Garrosa M; Pastor JC; Fernandez-Bueno I; Srivastava GK. Triple-layered mixed co-culture model of RPE cells with neuroretina for evaluating the neuroprotective effects of adipose-MSCs. Cell Tissue Res. 358 - 3, pp. 705 - 716. 2014.\nDOI: 10.1007/s00441-014-1987-5\n\nCarlo De Werra; Salvatore Condurro; Salvatore Tramontano; Mario Perone; Ivana Donzelli; Salvatore Di Lauro; Massimo Di Giuseppe; Rosa Di Micco; Annalisa Pascariello; Antonio Pastore; Giorgio Diamantis; Giuseppe Galloro. Hydatid disease of the liver: thirty years of surgical experience.Chirurgia italiana. 59 - 5, pp. 611 - 636.\n(Italia): 2007. ISSN 0009-4773\n\nChapters in books\n\t\n' Salvador Pastor Idoate; Salvatore Di Lauro; Jose Carlos Pastor Jimeno. PVR: Pathogenesis, Histopathology and Classification. Proliferative Vitreoretinopathy with Small Gauge Vitrectomy. Springer, 2018. ISBN 978-3-319-78445-8\nDOI: 10.1007/978-3-319-78446-5_2. \n\n' Salvatore Di Lauro; Maria Isabel Lopez Galvez. Quistes vítreos en una mujer joven. Problemas diagnósticos en patología retinocoroidea. Sociedad Española de Retina-Vitreo. 2018.\n\n' Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor Jimeno. iOCT in PVR management. OCT Applications in Opthalmology. pp. 1 - 8. INTECH, 2018. DOI: 10.5772/intechopen.78774.\n\n' Rosa Coco Martin; Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor. amponadores, manipuladores y tinciones en la cirugía del traumatismo ocular.Trauma Ocular. Ponencia de la SEO 2018..\n\n' LOPEZ GALVEZ; DI LAURO; CRESPO. OCT angiografia y complicaciones retinianas de la diabetes. PONENCIA SEO 2021, CAPITULO 20. (España): 2021.\n\n' Múltiples desprendimientos neurosensoriales bilaterales en paciente joven. Enfermedades Degenerativas De Retina Y Coroides. SERV 04/2016. \n' González-Buendía L; Di Lauro S; Pastor-Idoate S; Pastor Jimeno JC. Vitreorretinopatía proliferante (VRP) e inflamación: LA INFLAMACIÓN in «INMUNOMODULADORES Y ANTIINFLAMATORIOS: MÁS ALLÁ DE LOS CORTICOIDES. 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