Timothy Radstake

Radboud University NijmegenNetherlands

Dr Timothy Radstake, MD, PhD, attended medical school at the Radboud University in Nijmegen, the Netherlands, where he graduated in 2000 with the judicium Cum Laude. In 2003, he obtained his PhD (Cum Laude) on the genetic factors that determine the susceptibility to Rheumatoid arthritis, and the role of dendritic cells in this condition. He then started with his trainee ship rheumatology at the department of Rheumatology of the Radboud University Nijmegen Medical Centre. He became a staff rheumatologist in July 2011. From 2007 – 2008, he performed a post-doctoral fellowship at the Scleroderma center of the Boston University School of Medicine in Boston, MA, USA. Since then, he holds a faculty position, and together, with Prof. R. Lafyatis and Prof. M. Trojanowska, runs the immunology research line at this center. Currently, he is principal investigator of the research group translational immunology at the Nijmegen Center of Molecular Life Sciences (NCMLS) and Nijmegen Institute of Infection, Inflammation and Immunity (N4i).

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Latest work with IntechOpen by Timothy Radstake

Systemic sclerosis (SSc), or often referred to as Scleroderma (tight skin), is characterized by an exaggerated formation of collagen fibers in the skin, which leads to fibrosis. Accumulating evidence now points toward three pathological hallmarks that are implicated in Ssc, the order of which has yet to be determined: endothelial dysfunction, autoantibody formation, and activation of fibroblasts. This current book provides up-to-date information on the pathogenesis and clinical features of this severe syndrome. It is our hope that this book will aid both clinicians and researchers in dealing with patients with this clinical syndrome. In addition, we hope to shed more light on this rare and severely disabling syndrome, ultimately leading to better research and successful therapeutic targeting.

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