Risk matrix and associated potential damage.
\r\n\tAbout 25 percent of all foods produced globally are lost due to microbial growth. L. monocytogenes is a microorganism ubiquitously present in the environment and affects animals and humans. L. monocytogenes can enter a factory and is able to survive in biofilms in the food processing environment. The use of adequate sanitation procedures is a prerequisite in risk prevention. Moreover, effective control measures for L. monocytogenes are very important to food operators.
\r\n\r\n\tThe safety and shelf life maximizing of food products to meet the demand of retailers and consumers is a challenge and a concern of food operators.
\r\n\r\n\tTo obtain food systems more sustainable, several developments are ongoing to ensure safe food products with an extended shelf life and a reduction of food loss and waste. The problem of antimicrobial resistance is also a great issue that must be taken into consideration.
\r\n\r\n\tThe implementation of natural antimicrobials, using food cultures, ferments, or bacteriophages, is one approach to control L. monocytogenes in food products that meet the consumer preference for clean label solutions.
\r\n\tThis book intends to provide the reader with a comprehensive overview of the current state-of-the-art about Listeria monocytogenes in terms of occurrence in humans, animals, and food-producing plants. Its control by more natural agents allows for more sustainable food systems and points future directions to transform challenges into opportunities.
“It is a truism that each solution brings its own problems. Diabetic retinopathy in survivors of longstanding diabetes…represents the price paid for conquests that are not quite complete. The prolongation of life without corresponding prolongation of health, is loaded with intractable problems.” commented Arnold Sorsby on the “striking increase” of blindness from diabetes for both men and women between 1948 and 1962. [1]
\nThe next six decades saw intensive research in the pathogenesis and epidemiology of diabetic eye disease and the introduction of laser photocoagulation in the early treatment of diabetic retinopathy, pars plana vitrectomy for traction, and rhegmatogenous retinal detachment and intravitreal pharmacotherapy in the management of diabetic macular edema (DME), all addressing prevention of vision loss in these patients.
\nReports on the vision loss attributable to diabetes in the 1980s and 1990s vary greatly in their methodology—some have derived clinical information from hospital series, and others have reviewed the registry forms of certified disabled persons from the records of societies of the blind; there are reviews on patients referred to low vision rehabilitation centers and finally some present data from population-based observational studies. Each source has its shortcomings. Definitions in registry databases depend on the national disability legislation and often differ from the categories for blindness and low vision in the International Classification of Diseases (ICD)—Ninth and Tenth Revisions—that were in use at that time. Many authors stress on the difficult task of identifying the onset and the main cause of vision loss in diabetic patients with multiple ophthalmic comorbidities, especially in their final stages. For a long period, well into the 1980s, non-ophthalmic professionals were allowed to certify blind persons for registration that raises reservations regarding the accuracy of the cause. A common concern is the inability to determine the number of underreported and unregistered diabetic persons with vision loss as registration is voluntary, and it depends on clinical, social, and cultural factors; many authors have noted a rise in the incidence rates of DR with the arrival of more consultants in the area, after upgrade in the financial benefits and social support for legally blind or following campaigns to improve public awareness and reduce stigmatization.
\nHospital series analyze clinical data collected in specialized diabetic units over long periods in a consistent manner and provide reliable estimate on the severity and progression of vision loss; however, extrapolations of their findings for the population beyond their urban region are seldom possible.
\nPublications from the UK, Denmark, and Sweden demonstrate a decrease in the incidence of new blindness from DR in the 1980s and 1990s [2, 3, 4, 5]; however it remained unchanged between 1967 and 1991 in Italy and Avon, UK [6, 7]. In their review on the trends in blindness in Singapore, See et al. [8] present a sharp increase in the prevalence of diabetes in the age between 15 and 69 from 1.99% in 1975 to 8.6% in 1992 and a rise in the proportion of blindness from diabetic complications from 5% in the 1950s to 47.3% in the 1980s.
\nGlobal data on blindness [9, 10], a review report of the WHO programme for prevention of blindness, summarized available information from population-based assessment of visual loss and its causes. DR was not among the four major causes for blindness and low vision globally and ranked between the first and fourth only in Western Europe, the former socialist economies of Europe, North America, Latin America, and Oceania. The authors note the lack of relevant epidemiological data for some specific causes of blindness; however they emphasize that this disease is “generally recognized to be the leading cause of blindness among those in working age in developed countries and rapidly emerging in urban areas of the developing world.”
\nAn update on the estimates of global and regional blindness and low vision was published in 2004 presenting results of new population-based studies and other sources of information. The proportion of DR rose to 4.8% globally, and it was ranked fifth as a cause of blindness, with significant regional variations reaching 17% for North America and Australia, 17–15% in Europe, and 3–7% in the rest of the world where the majority of vision loss was due to cataract, glaucoma, and corneal opacities as complications of trachoma [11].
\nA meta-analysis of all available population-based studies performed worldwide from 1990 to 2010 [12] estimated that 833,690 people were blind and 3.7 million were visually impaired globally in 2010 due to DR. The highest number of blind diabetic patients was in South Asia, 295,000; North Africa/Middle East, 108,000; Eastern sub-Saharan Africa, 50,000; and Western sub-Saharan Africa, 66,000. The age-standardized prevalence of blindness from diabetic retinopathy in people over the age of 50 years was 0.05% globally, reaching 0.19% in Western sub-Saharan Africa, 0.16% in North Africa/Middle East, 0.14% in Eastern sub-Saharan Africa, and 0.12% in Southeast and East Asia. Moderate and severe vision impairment due to DR affected 3174 million, and the largest number of them were in South Asia, 1450 million, followed by North Africa/Middle East, 336,000; Eastern Asia, 279,000; Western Europe, 225,000; Western sub-Saharan Africa, 193,000; Eastern Europe, 166,000; Eastern sub-Saharan Africa, 128,000; and Central Latin America, 109,000. The age-standardized prevalence of moderate and severe vision impairment due to DR in people over the age of 50 years was 1.9% globally and was highest—0.51%—in South Asia, 0.50% in Western sub-Saharan Africa, 0.44% in North Africa/Middle East, 0.36% in Southern Latin America, 0.33% in Central sub-Saharan Africa, 0.32% in Andean Latin America, 0.31% in Eastern sub-Saharan Africa, and 0.26% in Oceania [13]. From 1990 to 2010, the number of blind diabetics had increased by 27% and those with visual impairment by 64% globally. Globally, age-standardized prevalence of blindness and vision impairment of diabetics over the age of 50 years was relatively unchanged in the course of these 20 years. It reduced by half in high-income Pacific Asia, Europe, Australasia, and North America; however it remained high in large, densely populated regions of Africa and Asia with rapidly increasing prevalence of diabetes.
\nA continuation of this systematic review and meta-analysis of data from 261 population-based studies published till 2014 [14] observed that while blindness to all causes reduced between 1990 and 2015, DR was the only one with prevalence that increased by 7.7% for blindness and by 28.6% for impairment. The proportion of vision loss attributable to diabetes ranked seventh in 2015 at 1.06% (0.15–2.38) globally and was highest in Eastern Europe, 4.91%, followed by Australasia, high-income North America, high-income Pacific Asia, and Central Asia. The contribution of DR to moderate and severe vision impairment was 1.30% (0.20–2.93) and reached 5.06% in Eastern Europe, followed by Australasia, high-income North America, high-income Pacific Asia, and Central Asia. The same regions were leading in the percentage of blindness and low vision due to DR for people over the age of 50 years. The age-standardized prevalence of blindness from DR across all ages was relatively low, in the range of 0.00–0.01 (0.00–0.02), and was considerably higher for vision impairment, 0.03% (0.00–0.13), with Eastern Europe ranking first at 0.11%, Central Asia, 0.09%; Southern Latin America, 0.08%; and North Africa/Middle East and Australasia, 0.07%. The age-standardized prevalence of blindness of diabetics over the age of 50 was 0.02% (0.00–0.07) and was highest in North Africa/Middle East, Eastern Europe, and Central Asia. The age-standardized prevalence of low vision in the same age group was 0.13% (0.01–0.48), and the same regions were most affected. For the first time, this report presented data on the gender differences in the cause and magnitude of vision loss and demonstrated that the relative risk of blindness and vision impairment in diabetic women as compared to men was 2.52. The number of people with blindness due to diabetic retinopathy was estimated at 400,000 (0–1.5 million) and low vision 2.6 million (0.2 million—9.9 million), both almost doubled since 1990. The projections for diabetic complications for 2020 are for further increase, and the largest number of people are expected to reside in North Africa/Middle East, 73,000 blind and 4,480,000 with low vision; Eastern Europe, 47,000 blind and 362,000 with low vision; Western Europe, 46,000 blind and 422,000 with low vision; East Asia, 41,000 blind and 400,000 with low vision; and Southeast Asia, 30,000 blind and 216,000 with low vision. The authors point out that the prevalence of any DR and sight-threatening DR was similar in men and women, whereas their analysis suggested female preponderance for vision-impairing DR. They attribute this discrepancy to the use of aggregated data for both genders combined in some of the studies and highlight the need for further research into the gender differences. There are considerable regional variations in the blindness and low vision due to DR, and they are related to the prevalence of diabetes in the population and the life expectancy of the diabetic patients. In the Middle East, Kuwait, for example, the prevalence of diabetes has reached 20–25% of the whole population and over 50% after the age of 60 years. In some regions, in particular in South Asia, the life expectancy of diabetic individuals is reduced, they do not have the chance to develop retinopathy as sequela of the disease, and the prevalence of debilitating retinopathy is low despite the high proportion of diabetes.
\nA detailed meta-analysis of the trends in vision loss in high-income countries in Pacific Asia, Australasia, North and Latin America and Western Europe, as well as Central and Eastern Europe from 1990 to 2015 [15] presented a relatively low and stable prevalence of blindness due to DR for all ages in the range of 0.01–0.02% in the whole super-region; however the rates for moderate and severe visual impairment varied in the range from 0.6–0.7% in most of the high-income countries to 1.6% in Eastern Europe and Australasia. The crude prevalence of blindness among diabetics over 50 years was in the range of 0.02–0.03% in the high-income countries, 0.04% in Central Europe, and 0.06–0.07% in Eastern Europe, and visual impairment was lowest in Western and Central Europe and Pacific Asia, followed by North America and Australasia and highest in Eastern Europe. The projections for 2020 were for stable or slightly reduced prevalence of blindness and gradual increase of patients with visual impairment in the super-region.
\nVision loss in the multiethnic population of Singapore over the age of 40 years was investigated in a series of population-based studies that demonstrated relatively high prevalence of diabetes in the sample—29.5%; DR was the second leading cause of vision impairment and blindness, and Indians and Malays were more affected than the Chinese. The authors point out that DR-related blindness in these three ethnicities in Singapore was less than the mainland Southern Indians, mainland Han Chinese, and peninsula Malays, and they attribute this to better access to qualified eye screening and care in Singapore. Diabetes was a significant contributing factor for visual impairment generally and increased the risk by 2.96 for people below the age of 60 years and 12.70 times for those over 60, particularly for females and patients with cognitive impairment and deafness, a tendency that was consistently observed across Malays, Indians, and Chinese. Diabetes in combination with other comorbidities, hypertension, hyperlipidemia, cardiovascular, or renal disease, was associated with higher risk of vision loss, up to 9.51 for people younger than 60 years and 26.56 for those older than 60, particularly for Indians, and an interaction effect for concomitant diabetes and renal diseases [16].
\nVision-threatening DR (VTDR) is a compound term used in the literature for the presence of proliferative disease grading over level 60 by EDTRS scale and its modification and/or macular edema in its various stages [17, 18], and its magnitude is essential for planning the life-long management of these patients and prevention of blindness. The prevalence and risk factors of VTDR were estimated in a large meta-analysis of 38 population-based studies from Australia, the USA, Europe, and Asia involving 42,091 participants from 20 to 79 years with diabetes. There was no discernible sex difference in the age-standardized prevalence of VTDR, 11.7%; it was highest among African Americans, 16.89%; followed by Caucasians, 15.45%; and Hispanics, 10.35, and was lowest in South Asians—5.2%. Duration of diabetes (DM) was associated with rapidly increasing prevalence from 3.53% for DM less than 10 years to 17.78% for 10–20 years and up to 87% for more than 20 years. Metabolic control, estimated by the levels of HbA1c, directly affected the extent of VTDR—the disease doubled in patients with levels between 7.1 and 8.0% and tripled among those with more than 9.0%. Elevated blood pressure over 140/90 and hypercholesterolemia over 4.0 mMol/L elevated the risk of VTDR twice, particularly for macular edema. Individuals with type 1 diabetes for more than 20 years were 15 times more likely to have proliferative diabetic retinopathy (PDR) (15.3 [11.3–20.8]), 5 times more likely to have DME (4.83 [3.71–6.30]), and 8.7 times more likely to have VTDR (8.69 [7.10–10.63]) than those with type 2 diabetes for less than 10 years. On a positive note, the prevalence of VTDR reduced from 15.62% in studies where the fundus photographs were taken before the year 2000 to 7.86% in the studies with assessment of the patients after 2000.
\nThis pivotal work highlighted the importance and cutoff levels of the systemic factors associated with progression of DR to sight-threatening stage and the need for close collaboration with the treating diabetology team. It outlined the profile of the patients at risk of vision loss with their features—type and duration of diabetes, levels of metabolic control, hypertension, and hypercholesterolemia. The role of ethnicity was limited to the populations studied, and the authors note the absence of studies from Middle East, Africa, and South America that could affect the accuracy of their global estimates. The differences in the rates of VTDR in the various populations could be due to both genetic factors and access to health care. Ethnicity itself is multidimensional, and it may not be possible to differentiate its effect from the risk associated with remoteness, urbanization, lifestyle, education, health awareness, and individual income.
\nSocial and economic factors have a fundamental impact on the visual prognosis of diabetic eye disease. A number of studies have investigated the negative influence of deprivation on the prevalence of diabetes, access to evaluation and care, level of metabolic control, and rate of complications and were reported in systematic reviews for type 1 [19] and type 2 diabetes [20]. Remoteness [odds ratio (OR) 2.02] and diabetes in combination with never having had an eye examination (OR 14.47) were among the main risk factors for vision loss in indigenous Australians, and blindness prevalence was 2.8 times higher among them than in non-indigenous Australians after age and gender adjustment [21]. The presence of PDR was associated with low income (OR = 3.6 for developing PDR if income was less than $20000) in the Proyecto VER Study in the USA involving 4774 Hispanics over the age of 40, after controlling for other factors [22]. Deprivation, as a comprehensive measure of income, employment, health and disability, education, crime, barriers to housing, services, and living environment at the level of small geographic areas, was developed in the UK as a numerical index per residential code and used in a large national database study of 79,775 diabetic patients to highlight its effect on visual acuity and need for early treatment at first hospital presentation [23]. The OR of presenting with “sight impairment” at first visit to the hospital eye service was gradually decreasing from 1.29 in the most deprived group to 0.77 in the least deprived one, and OR for “severely sight impaired” was 1.17 in the most deprived decile versus 0.88 in the least deprived one. The risk of sight-threatening maculopathy and vitreous hemorrhages showed little variations across the deprivation range, and tractional retinal detachment was less likely in the two least deprived deciles. The large scale of the study and use of “real-world” multicenter in-hospital dataset provided statistical strength to the conclusion that the impact of deprivation extends to late presentation of retinopathy, significant loss of vision at presentation, and a pattern of advanced retinal complications that affect the treatment these patients receive. Financial factors are often self-reported by diabetic patients who are missing screening appointments and treatment sessions. However a study in Tanzania revealed that the reasons for poor compliance are more complicated. The clarity of referral process and ease of navigation through the unfamiliar hospital environment are essential, particularly for the elderly and less educated patients from remote areas [24]. Another formidable obstacle is the widespread complacency and fatalistic resignation with the notion that retinopathy will inevitably end up with blindness. Constant assurance and encouragement that diabetic eye disease is a treatable condition with good prognosis is a practical strategy to prevent delays in diagnosis of sight-threatening complications. Lack of education greatly affects the health awareness and adherence with retinopathy management. In Kuwait, 16% of the men and 46% of the women over 65 years are illiterate, and 20% of the men and 24% of the women in the same age group can only read and write [25]. This is a significant barrier to in-depth understanding and compliance with recommended treatment and lifestyle and eventually compromises the visual outcome despite the high economic standard of the Kuwaiti nationals and availability of services in the country. Family support greatly improves the continuum of care and is essential for the regular attendance of the patients, especially females from a more conservative background.
\nProgression of nonproliferative to proliferative disease was investigated in several large cohort studies [26, 27]. Disease severity was estimated by the EDTRS classification and taken separately for each eye or concatenated as the bilateral grade, and progression was defined as the increase of two or more steps in severity. The rate of progression to PDR varied greatly—it was from 4 to 9.9% in the first 4–5 years and 8–12% in the next 5 years and reached a cumulative level of 31% after 16 years and 42% after 25 years in type 1 and type 2 diabetics. There are differences between the populations and methodology applied in the hospital-based and community-based studies as more patients with severe disease that required active management were probably referred to tertiary care centers [28, 29, 30, 31, 32].
\nThe diagnosis of diabetic macular edema has evolved with the introduction of stereoscopic photography of the posterior pole and optical coherence tomography (OCT). The presence of any edema and clinically significant edema (CSME) by the modified EDTRS classification has been investigated in multiple hospital series and population-based studies. Detection of DME in non-stereoscopic fundus photographs is less sensitive to milder forms with recent onset, and probably the reported prevalence covers the more severe chronic stage. The prevalence of CSME in type 1 patients was from 5.73% in Spain to 9.4% in Brazil [33, 34]. Among patients with type 2 diabetes, it was in the range from 1.4% in Portugal to 12.8% in Denmark [35, 36]. There are reports indicating that the prevalence of DME in Central and Eastern Europe [37], North Africa, and Middle East [38] is considerably higher, and further research on the magnitude of CSME and risk factors for its progression will contribute to the estimates of sight-threatening retinopathy globally.
\nDiabetic nephropathy (DN), the primary cause of chronic kidney disease, is significantly associated with incidence and progression of diabetic retinopathy as demonstrated in Brazilian [39], Spanish [40], Korean [41], Taiwanese Chinese [42], and Australian [43] patients. The presence of chronic kidney impairment had adjusted a hazard ratio of 5.01 for nonproliferative and 9.7 for proliferative disease as compared to patients without nephropathy. At 5-year follow-up, the hazard ratio of progression to PDR was 2.26 in patients with DN, and it was related to the levels of microalbuminuria and estimated glomerular filtration rate with cutoff below 60 mL/min/1.73 m2 [44]. Hypertension and DN in patients with chronic kidney disease increased the risk of progression to proliferative disease; however diabetic nephropathy did not significantly affect the development or progression of DME. Among the Taiwanese Chinese patients, diabetic macular edema had high crude hazard ratio association with cerebrovascular accidents and lesser one for hypertension and use of statins; however the significance was lost after controlling for age, sex, comorbidities, and medications.
\nDiabetes affects 17% of pregnancies worldwide and can be pre-existing type 1, gestational, or type 2, in some of the patients—previously undiagnosed. The highest rate of diabetes in pregnancy is recorded in Southeast Asia, 25%, and the prevalence of pre-existing diabetes is highest among women from the Middle East and North Africa—3.1%. Australian mothers who were born in high diabetes risk areas such as Polynesia, Asia, and the Middle East are 1.4 times more likely to have type 2 diabetes during pregnancy [45]. Similarly, in the USA and UK, patients belonging to Black, Asian, Hispanic, and Pacific Island ethnic minorities had higher proportion of pre-existing diabetes and pre-existing type 2 DM. Progression of retinopathy during pregnancy is related to the level of diabetic retinopathy prior to conception and was noted in 58% of the patients with moderate or more severe DR at baseline. Duration of diabetes type 1 greater than 15 years and type 2 more than 6 years was significantly associated with higher rate of progression of retinopathy in patients with pre-existing proliferative disease. Poor glycemic control prior and during pregnancy was an independent risk factor for retinopathy progression; however tight control and rapid optimization of metabolic control in such patients were associated with worsening of retinopathy. As the long-term benefits of proper glycemic management outweigh the short-term risk of deteriorating retinopathy, optimal control is currently recommended prior to and as soon as possible after conception for the health of the mother and fetus. Progression of retinopathy during pregnancy was significantly higher in diabetic patients with preeclampsia, with sight-threatening complications in 50% of the diabetic women with preeclampsia compared to 8% without it [46]. Other risk factors for deteriorated retinopathy during pregnancy include young age of type 1 onset, insulin treatment in type 2 prior to pregnancy, low vision at baseline, and pre-existing macular edema at baseline [47].
\nDiabetic foot syndrome is one of the important consequences of long-term uncontrolled diabetes, which occurs due to a combination of peripheral neuropathy and microvasculopathy in the lower extremities. It may vary from a minor ulceration to necrosis of tissues, sometimes warranting amputation [48]. Several hospital series demonstrated the presence of retinopathy in 90–95% and proliferative disease and severe nonproliferative changes in 39–55% in such patients independent of the ulcer severity [49]. Diabetic foot syndrome in type 1 and type 2 diabetic patients with retinopathy was associated with higher levels of HbA1c, serum creatinine, older age, and lower hematocrit, particularly elevated in the subgroup with proliferative disease—all characteristics of concomitant chronic kidney disease and neuropathy in poorly controlled, long-lasting diabetes. Despite the lack of data on macular edema, the presence of any stage of diabetic foot ulcer is emerging as a predictor for retinopathy deterioration [50, 51].
\nThe overall prevalence of depressive symptoms in diabetic patients with retinopathy is estimated in the range of 35% in China to 50% in African Americans and is more prevalent in type 2 [52, 53]. The association between depressive symptoms, diabetes, and diabetic retinopathy is likely to be bidirectional: the impairment and burden of diabetes and its complications can precipitate depression and vice versa, and depression can impair diabetes control through various biological and behavioral pathways [54, 55]. Depression aggregates negative attitudes toward treatment and often leads to poorer glycemic control, less adherence to treatment, higher risk for PDR, greater morbidity and mortality, and higher costs [56]. Low income has been implicated in some research from the USA; however it was not found significant in a large cross-sectional study from Australia. Patients with longer duration of diabetes, worse glycemic control, lower educational level, and severe vision impairment below 20/63 were associated with greater depression symptoms. Symptoms of anxiety were associated with type 1 diabetes, presence of myocardial infarction/angina, arrhythmia, stroke, asthma, anemia, arthritis or osteoporosis, younger age, and female gender [57]. Severe NPDR and PDR, but not macular edema, were independently associated with depressive symptoms, and the authors suggest that severity of retinopathy could be an indicator to prompt monitoring of depression in at-risk diabetic individuals. Antidepressant medications have been associated with slowing the progression of retinopathy in diabetic patients. However the outcome was limited to subjects with elevated C-reactive protein over 0.3 mg/dL. Selective serotonin reuptake inhibitor users had significantly lower risk of developing severe retinopathy than non-SSRI users [58]. The results of longitudinal studies show that the speed of cognitive decline in type 2 diabetic patients is up to twice as fast as that of normal aging individuals and diabetic patients have an increased risk of mild cognitive impairment (MCI). In addition, type 2 diabetic patients had an almost twofold higher risk of developing Alzheimer’s disease than age-matched nondiabetic subjects. This increased risk was maintained even after adjusting for vascular risk factors. The annual conversion rate from MCI to dementia ranges between 10 and 30% in the general population, but this is much higher in the type 2 diabetic population. The impact of cognitive impairment on the compliance with lifelong retinopathy treatment and its outcome needs further evaluation; however clinical practice indicates the need for personalized multidisciplinary approach.
\nThe variability in the rate of progression to vision-threatening retinopathy and particularly in the response to treatment was noted from the onset of clinical and epidemiological studies in diabetic patients and has been attributed to the effect of genetic predisposition together with systemic and socioeconomic factors. Single-nucleotide polymorphisms [58, 59, 60] and genome-wide associations [61, 62, 63] have been investigated in patients with proliferative disease and macular edema, and the results so far are inconclusive mainly due to the size of the samples and the inclusion of cases with coexisting proliferations and edema in the cohorts. Detailed assessment in the polymorphisms of the VEGF gene revealed that some of them are related to higher susceptibility to severe retinopathy, but not to the outcome of ranibizumab intravitreal injections [64] in contrast to an earlier report on the response to bevacizumab [65]. In order to confirm the association of several novel genetic loci with severe retinopathy, replication studies and extension in additional cohorts and ethnic groups have been recommended [66]. Research of systemic and retinal inflammation as risk factors for DR and DME [67, 68], upregulated leptin [69, 70] and adiponectin [71], oxidative stress [72], and vitamin D deficiency [73] has provided significant associations. Reliable and accessible markers of these factors can be important predictors of the disease severity and progression and thus provide early guidance in personalizing the monitoring and treatment of the patients at risk of vision loss.
\nThe introduction of intravitreal anti-VEGF drugs and corticosteroid implants revolutionized the management of DME. Prospective randomized clinical trials have addressed the efficacy and safety of different types of agents and administration regimens and have shown wide variations in terms of visual acuity gain. In the DRCR.net trial, after 2 years of treatment, approximately 98% of the patients maintained their visual acuity and attained visual gain in 37% of the patients on ranibizumab, 35% of those on bevacizumab, and 39% of those on aflibercept [74]. Stratified analysis of RESTORE in DME, RETAIN, and Protocol I demonstrated that the most significant gain in number of EDTRS letters after 12–36 months was in patients with baseline BCVA 60 and less letters in the range of 8.6–10.36 letters, versus the gain for patients with baseline BCVA 61–71 letters who achieved 7.96–4.36 letters, and the least gain of 5.42–4.2 letters was in the group with baseline BCVA better that 73 letters [75]. Thus, the patients with most severe vision deterioration and baseline BCVA in the range of 20/320–20/63 who responded favorably to 2 years of intensive therapy improved to BCVA from 20/160 to 20/40. High visual acuity in the range of 20/40–20/32 was achieved only in patients with baseline BCVA over 20/30 despite the small number of gained EDTRS letters. The range and stability of this visual improvement depended on increasing age, level of glycemic control, and previous panretinal photocoagulation [76]. OCT markers of better functional outcome after anti-VEGF treatment were the presence of intact ellipsoid zone and lack of hyperreflective spots or disruption of the inner retinal layers, which are seen in patients with more recent onset of the edema and no previous macular grid laser [77]. Patients with chronic macular edema had considerably better functional and structural results after treatment with steroid implants. Visual gain of more than 15 letters was achieved in 22% after 3 years on intravitreal dexamethasone [78] and in 34% after 3 years on fluocinolone acetonide [79]. Eyes with submacular fluid, no hyperreflective foci, and a continuous IS-OS layer responded better to dexamethasone implants with gain of 10 or more letters after 2 and 4 months [80]. The adverse effects of both implants included the formation of cataract, 13–50% after 1 year on dexamethasone and 82% after 3 years on fluocinolone acetonide, and intraocular pressure rise over 25 mmHg in 42% of the eyes with dexamethasone and 38% with fluocinolone acetonide; however a small percentage required glaucoma surgery—0.5% of the eyes with dexamethasone and 4.8% with fluocinolone acetonide. Patients with poorly controlled diabetes and DME, severe nonproliferative or proliferative disease, epimacular membranes, myopia, glaucoma, and various degrees of cataract are excluded from the randomized clinical trials; however such cases are predominant in real-world practice and add new dimensions to the challenge of visual rehabilitation. Analysis of large electronic medical record databases from the USA [81] and Korea [82] demonstrated visual outcomes that are meaningfully inferior to those in the clinical trials and were attributed to undertreatment and lack of close monitoring. A sizable group of DME patients were lost to follow-up in the initial stages of anti-VEGF treatment—25% were reported from a single retina practice in the USA and the main risk factors were being Hispanic, Black, or a Pacific islander; low income, AGI less than $50,000; and decreasing baseline visual acuity [83]. In a study of European DME patients, 46% had at least one break-off in their anti-VEGF treatment for more than 100 days, and the most common reason for poor compliance was comorbidity. In 60% of these cases, the visual acuity deteriorated significantly after the break [84]. Prevention of vision loss from diabetic macular edema is achievable with the current therapeutic modalities; however it requires very early identification at stages with relatively high visual acuity and needs the introduction of best-corrected visual acuity and OCT in the screening protocol. As shown in the Protocol G—Subclinical DME study of the DRCR.net that involved a longitudinal assessment of eyes that had retinal thickening on OCT without thickening on clinical exam, a progression to clinically apparent DME was seen in 23–58% of eyes within 2 years.
\nVision loss in approximately 25% of patient with diabetic retinopathy is associated with complications of proliferative disease. An estimated 17 million diabetic people worldwide have PDR [17], and without treatment more than half of the patients with high-risk PDR will be blind within 5 years. Panretinal photocoagulation was established as an effective treatment to reduce by 50% the incidence of severe vision loss, if performed prior to the development of vitreous hemorrhages and tractional retinal detachment [85]. Still, the EDTRS has shown that 5% of patients with PDR will require vitreous surgery despite having received adequate PRP [86]. The Diabetic Retinopathy Vitrectomy Study validated the superiority of vitrectomy over observation; however despite the fact that the trial did not include patients with macula, involving traction, the visual outcome was low. Subsequent studies on vitrectomy for PDR reported that between 10 and 20% of the patients did not improve their visual acuity above hand motion or less [87]. Favorable factors for visual rehabilitation after vitrectomy for macula-involving tractional retinal detachment included short duration of detachment, previous panretinal photocoagulation, and lack of severe neovascularization and vitreous hemorrhage. Predictors of poor visual results were iris neovascularization and neovascular glaucoma, papillo-vitreal traction, baseline visual acuity below 20/200, initial macular detachment, intraoperative iatrogenic break, or use of heavy silicone oil [88, 89, 90]. Functional outcome was significantly affected in patients with postoperative macular ischemia, recurrent vitreous hemorrhage, optic atrophy, epiretinal membranes, and recurrent retinal detachment [91, 92]. The introduction of small-gauge vitrectomy instruments and trans-scleral cannulas enabled the fast and effective removal of most fibrovascular membranes with the vitrectomy probe applying the lift and shave technique [93]. Visual outcomes were poorer in older age group, tractional retinal detachments involving macula and eyes with extensive membranes and with silicone oil as tamponade; however both 23-gauge and 25-gauge groups were comparable in relation to visual improvement, anatomical success, and intraoperative and postoperative complications [94]. The integration of swept-source optical coherence tomography and digital displays can provide important guidance during surgery for PDR complications and facilitate decision-making [95]; however further research will show whether these technological advances will translate into better postoperative visual outcome.
\nMedical treatment for PDR has had minimal advancement over the past 40 years since the wide acceptance of panretinal photocoagulation in the early management of the disease. Regression of proliferative activity was noted in eyes treated with anti-VEGF for concomitant macular edema [96] and that lead to a series of trials on aflibercept and ranibizumab versus panretinal photocoagulation in the management of PDR. Both drugs were superior to PRP in 1 [97] and 2 years [98] in terms of visual acuity and visual field sensitivity. Assessment of the peripapillary retinal nerve fiver layer thickness in patients treated with ranibizumab revealed reduction that was due to decreased edema rather than loss of axons [99]. Patients with mild and moderate vitreous hemorrhages treated with ranibizumab had significantly less need for vitrectomy, less recurrences of hemorrhage, and better visual acuity on all follow-up visits than the patient under observation or operated for non-resolving or aggravated hemorrhages [100]. However, despite the improvement in retinopathy severity on color photographs, the retinal perfusion did not improve on wide-field fluorescein angiography that revealed no reperfusion of small vessels in areas of previous capillary non-perfusion [101]. Diabetic patients are prone to significant loss to follow up due to illness, financial hardship, and lack of compliance. The rate of complications and loss of vision after unintentional interruptions for more than 6 months in PDR patients treated only on anti-VEGF was considerably higher than the eyes that received PRP, with a significantly higher number of eyes with tractional retinal detachment and neovascularization of the iris [102]. In a retrospective review of 13 eyes treated exclusively with anti-VEGF for PDR with or without macular edema or severe NPDR with macular edema, with hiatus of 12 months, 9 presented with vitreous hemorrhage, 5 with neovascular glaucoma, and 4 with tractional retinal detachment. Despite the aggressive treatment of the complications, 10 eyes lost more than 3 lines of vision, and 2 had final vision hand motions [103]. So, while anti-VEGF proved to be effective for PDR in the clinical trials, in real-world the unclear long-term advantages of pharmacological monotherapy over PRP, the increased cost, and treatment burden are not optimal for many diabetic patients.
\nNeovascular glaucoma is a late complication of proliferative disease with chronic ischemia in the posterior segment and development of a fibrovascular membrane on the anterior surface of the iris and iridocorneal angle of anterior chamber, and usually its onset correlates with poor glycemic control. In the early stages, iris neovascularization can be found without elevated IOP. Panretinal photocoagulation remains the mainstay in controlling the neovascular drive and should be considered in all cases of neovascularization of the anterior segment when retinal ischemia is present. After panretinal photocoagulation, complete regression of retinal neovascularization can be reached in 67–77% of cases, visual loss can be prevented in 59–73%, and IOP reduction can be achieved in 42% [104]. Anti-VEGF injections can lead to regression of both iris and angle neovascularization and improve intraocular pressure control when the angle remains open. However, the effects of anti-VEGF agents seemed to induce only a temporary regression of new vessels in the anterior chamber angle and IOP reduction, generally lasting between 4 and 6 weeks [105]. Glaucoma drainage devices are usually considered the first treatment option for refractory glaucoma. Neovascular glaucoma patients are at greater risk for surgical failure after glaucoma valve surgery compared with non-neovascular glaucoma controls. A recent retrospective, comparative, case series of 163 eyes of 151 patients with neovascular glaucoma included 99 treated without and 64 treated with intravitreal bevacizumab. IOP decreased to 18.3 ± 13.8 mmHg in the non-bevacizumab group and 15.3 ± 8.0 mmHg in the bevacizumab group. Panretinal photocoagulation substantially reduced the need for glaucoma surgery (
Impairment of vision in diabetic patients is not limited to retinopathy—the leading causes of deteriorated vision and progression of vision loss in a cohort from South India were cataracts and uncorrected refractive errors [108]. The introduction of phacoemulsification significantly reduced the surgical trauma and leads to a growing tendency toward earlier cataract surgery in diabetic patients [109]. This approach facilitates panretinal photocoagulation and allows for the identification and adequate treatment of diabetic macular edema before and after cataract surgery. Preexisting macular edema can increase the risk of edema progression by 20–50%, and intravitreal anti-VEGF agents are recommended perioperatively [110]. Steroids, on the other hand, have been shown to be effective for persistent or refractory diabetic macular edema prior to and after cataract procedures. Dexamethasone implants and fluocinolone implants resulted in significant improvement in clinically significant macular edema and visual outcomes [111]. Despite the advancement in phacoemulsification technology, poor visual acuity following cataract extraction is still common in patients with diabetes. Posterior capsule opacification, postoperative cystoid macular edema, diabetic macular edema [112], and worsening of the DR are the main complications seen in diabetic patients. According to the Early Treatment of Diabetic Retinopathy Study, the presence of clinically significant diabetic macular edema at the time of cataract surgery was significantly associated with poor visual acuity and was a predictor of final visual acuity worse than 20/200 following uncomplicated phacoemulsification [113]. The severity of DR at the time of cataract surgery is also a significant determinant of postoperative VA; more severe retinopathy seems to be associated with an increased prevalence of macular ischemia or edema and a reduced tendency for spontaneous resolution of postoperative macular edema with associated poor postoperative VA. Treatment-naïve PDR before cataract surgery may progress to vitreous hemorrhage and tractional retinal detachment following phacoemulsification, thus threatening good visual outcome [114].
\nIn conclusion, vision loss due to diabetic complications in the eye is growing worldwide despite availability of screening programs, advanced diagnostic tools, pharmacotherapy, and rapidly evolving surgical technology. Prevention requires:
Identification of the social groups and individuals at high risk of vision-threatening diabetic complications
Coverage with diabetic retinopathy screening with introduction of AI tools, wide-field retinal assessment, telemedicine, and OCT of the posterior segment
Outreach of qualified management closer to the diabetic patients’ communities
Early, intensive management before significant vision loss
Lifetime, highly qualified monitoring and early management of complications
Close, continuous collaboration with the treating diabetology team
Involvement of the family, community, diabetic patients’ organizations, and social media in patient care, adherence to treatment, prevention of physical and mental disability, and improvement of quality of life
The increase in the number of dams has increased the concern with the safety of these structures [1]. Major accidents with dams have drawn attention to this problem, as failures in these structures can cause irreversible environmental damage, as well as human and animal deaths.
Advantages in the implementation of cascade dam projects have made this conception commonplace and risk analysis a complex activity. The advantages of these projects include simplifications derived from decentralisation (lower cost, implementation time and complexity to comply with legislation); the possibility of storing water to generate electricity in downstream dams; the transformation of stretches that are not navigable into waterways; full use of the flow of water; the development of rolling projects; and coordinated dispatch of energy [2–4].
Within this context, numerous studies have been developed to provide subsidies for operation, maintenance and decision-making in the area of dams. Some of these studies are briefly presented in the sequence. In a work on the Dadu River basin, one of the main rivers in China, transmission risk and overtopping between dams in cascade reservoirs were studied [3]. Dam risk was divided into two parts: own risk and additional risk. Based on this, a methodology that considers the relevant concepts and equations for calculating the risk probability of dams in cascade reservoirs was proposed. The results indicated that the proposed methodology realises an effective connection with the risk calculation of the single-reservoir dam method, which can provide a reference for the risk assessment and management of cascaded reservoirs in the basin [3].
The research focused on the genetic-algorithm-based optimisation of rule curves to maximise hydropower and associated benefits through cascading reservoirs [4]. The optimisation was performed using RESOOSE model and applied to multipurpose Diamer Basha and Terbela reservoirs on Indus River in Pakistan. According to [4], the results show that hydropower was optimised along with the maximisation of associated benefits (power generation, irrigation and sediment discharge).
A study to describe the principles of dam risk classification methods, the International Commission on Large Dams (ICOLD) method and the Bureau method, and comparatively discussing total risk classifications was carried out by Topcu and Tosun [5]. In conclusion, the following stand out: the safety assessment for cascade dams should be different from that of a single dam; the rupture of any dam in a cascade structure may result in overtopping or breakage of the dam or dams downstream; the probability of rupture of any dam in a cascade structure is higher than that of a single dam; and a new safety concept should be developed for dams in a cascade system [5].
Some topics considered important for the study of dam safety in Brazil are presented in the following.
In this context, the National Dam Safety Policy (PNSB in Portuguese), established by [6] and amended by [7] aims to ensure that dam safety standards are followed (mainly by developers) to reduce the possibility of accidents and their consequences, as well as regulate safety actions and standards. The policy defines a dam as any structure built inside or outside a permanent or temporary watercourse, in a thalweg or in a diked pit, for the purpose of containment or accumulation of liquid substances or mixtures of liquids and solids, comprising the dam and associated structures.
An important instrument of the National Dam Safety Policy, which must be implemented by developers, is the Dam Safety Plan (PSB in Portuguese), whose objectives are to assist and serve as a planning tool in the dam safety management. In the Dam Safety Plan structure, the information and technical data of the dam referring to construction, operation, maintenance and the overview of the current state of safety, obtained through regular periodic inspections, must be documented. For multipurpose dams inspected by the National Water and Sanitation Agency, this agency issued [8] establishing the implementation of procedures, including the minimum content and level of detail of the Dam Safety Plan.
Depending on the conditions of each dam, the Dam Safety Plan may require preparing up to six volumes, distributed as follows: Volume I—General Information; Volume II—Technical Documentation of the Project; Volume III—Plans and Procedures; Volume IV—Records and Controls; Volume V—Periodic Review of Dam Safety (PRDS); Volume VI—Emergency Action Plan (PAE), when required.
Dams can be built for various uses, including irrigation, aquaculture, human water supply, industrial water supply, animal watering, leisure, fishing, electricity generation and disposal of mining and industrial tailings, among others.
Dam classification consists of an instrument of the National Dam Safety Policy and is a procedure normally carried out by inspection bodies, following the criteria of [9], and was established by the National Water and Sanitation Agency, the Risk Matrix and Associated Potential Damage. It is known that currently (in 2022), there are negotiations to be carried out with the updating and adequacy of the Brazilian National Council of Water Resources (CNRH) definitions and recommendations.
According to the aforementioned law and its amendments, the definition refers to the classification of the dam risk category (DRC) by the associated potential damage (APD) and by its reservoir volume. In the DRC, aspects that may influence the possibility of an accident or disaster are verified, taking into account the technical characteristics and the state of conservation, and the Dam Safety Plan, that is, the conditions of the risk of dam accidents due to failure or lack of adequate actions, is the developer’s responsibility.
On the other hand, the APD refers to damage that can occur due to failure, leakage, infiltration into the soil or malfunction of a dam, regardless of its probability of occurrence, to be graded according to the loss of human life and social impacts, economic and environmental.
The dams must be classified into five classes (A, B, C, D and E, presented in (Table 1), and those that present a higher degree classification, in the risk category scale and associated potential damage, must prepare a more complete plan.
Risk category | Associated potential damage (APD) | ||
---|---|---|---|
High | Medium | Low | |
High | A | B | C |
Medium | A | C | D |
Low | A | C | E |
Risk matrix and associated potential damage.
Currently, Brazil has 22,649 dams registered by 33 inspection bodies in the National Information System on Dam Safety (SNISB in Portuguese). There are 6507 dams assessed by DRC, and of these 2503 were classified as high DRC; there are 1388 dams assessed by APD, and of these 871 were classified as high APD.
The state of Mato Grosso, located in the Central-West region of Brazil, has five Dam Safety inspection bodies: (1) Mato Grosso State Secretariat for the Environment (SEMA-MT in Portuguese) inspects dams intended for multiple uses, located in state rivers; (2) National Water and Sanitation Agency (ANA in Portuguese) inspects dams intended for multiple uses, located in federal rivers; (3) National Mining Agency (ANM in Portuguese) inspects dams destined for the disposal of mining tailings; (4) National Electric Energy Agency (ANEEL in Portuguese) inspects dams intended for generating electric energy; (5) Brazilian Institute of Environment and Renewable Natural Resources (IBAMA in Portuguese) inspects dams intended to contain industrial waste. However, only four of these bodies are effectively inspected, except for IBAMA.
According to the National Information System on Dam Safety, there are currently 652 dams registered in the state of Mato Grosso. Of these, 262 are inspected by the Mato Grosso State Secretariat for the Environment, 132 by the National Water and Sanitation Agency, 141 by the National Mining Agency and 117 by the National Electric Energy Agency.
Dam safety has been a very important item for a long time, although in Brazil, the development of regulatory actions only took place after Law No. 12,334, on November 20, 2010. The improvement of actions evolved after the Inspection Agencies (federal and state) issued the respective regulations.
After establishing the National Dam Safety Policy, there were advances in dam classification and regularisation in Brazil. However, progress is still needed in terms of inspectors’ performance, specifically in dam regularisation (issuance of grants and environmental licences, among others), construction and refinement of registries, inserting dams into the National Information System on Dam Safety, dam classification, reviewing regulations [6] and on-site and documentary inspection actions. Most dams were not regularised and/or included in the National Dam Safety Policy by the inspection entities due to a lack of basic information such as height and volume, or because they were not classified as to the APD, or because of the difficulty in identifying the responsible developer [10].
As in several states in Brazil, the state of Mato Grosso also has problems regarding the safety of multipurpose dams located in state water bodies, as presented in [11]. This is because the competence in the state for managing civil works, such as dam construction, is carried out by another sector of the Mato Grosso State Secretariat for the Environment, which deals with environmental licencing, requiring strong coordination between the Water Resource Superintendence and other areas of the secretariat to carry out the actions proposed by the National Water and Sanitation Agency, as in the case of dam regularisation in terms of licencing, granting and dam classification, together with the fact that the state also has recently published regulations for dam regularisation.
Most multipurpose dams, located in existing state water bodies in the state of Mato Grosso, were predominantly built on land; they have a small reservoir area and height and are mostly characterised as small dams. They are mostly located on rural properties, with predominant uses for irrigation and aquaculture activities. These dams are, in many cases, maintained (not so adequately) by small developers who usually do not have sufficient technical knowledge for more accurate assessments and/or financial resources to hire qualified professionals. This situation is common in several regions of Brazil and in other parts of the world [12].
It was noted that the vast majority of them are located mainly on farms, but far from the sites where the caretakers are. Thus, there is little or no concern with dam safety on the part of developers, mainly due to the absence of specific regulation, until mid-2017, and, consequently, a lack of guidance, a lack of disclosure and notification and/or lack of knowledge. Most dams do not have a technician responsible for the structure and were built without having a project, without constructive care and without environmental licencing. Some were built for access purposes, on irregular terrain and ended up damming (rain) water. These normally do not present dam aspects, but they present risks because of the lack of adequate executive and maintenance conditions.
The dams in the best safety conditions are those that have the “regular road function”. In this case, there is no excess vegetation, at least at the crest of the dam. It can also be observed that the excess vegetation, a common characteristic found in the dams of the state, is part of a culture of the developers and employees of the farms, who must believe that the excessive vegetation (mainly trees on the crest) on the slopes would protect the dam. However, it is the opposite.
In the visits to the dams, it was noticed that some conditions are recurrent in the state’s dams and require care and maintenance, such as excess of high vegetation on the crest and slopes; crest cracks; fissures and erosion on the slope; infiltration moisture, on the downstream slope; and structures close to roads, which can cause socio-environmental impacts (and even deaths) in the event of a possible failure.
Most of the dam accidents, that had a loss of life, occurred in small and/or medium dams, with a height of less than 30 meters. Therefore, these dams have become a matter of concern and of greater interest to dam safety professionals [13].
In the state of Mato Grosso (MT), it is common to find these small dams located in the same watercourse (or in thalwegs), which can be sequential (when there is no negative effect of a dam on the downstream dam) or in cascade. Many are located close to highways and/or other infrastructure, which may represent high APD.
Dam failure is considered as a cascade, when the occurrence of an extreme event (with loss of resistance, or overtopping and/or overflowing) of one of them, generating a burst flood wave, may indicate that it serves as a cause for the possibility of failure of another dam, existing downstream (in the same watercourse or thalweg).
Each developer should manage the dams they own properly, so as not to assign additional risks to other dams in the cascade, which may even belong to other developers. The flood wave caused by a failure is generally greater than the design flow and capacity of the dam spillway or spillway immediately downstream, as the reservoir volume is released in a short time interval. This flood wave can cause the downstream dam to overflow (“overtopping”) and failure [14].
Given that in the state of Mato Grosso, there have already been cascading failures, which is a concern for the inspection body, there is a need to develop differentiated procedures for the regularisation and classification of these structures. Thus, the objective of the study is to analyse the possibility of failure, according to the conditions of dams located in the same watercourse (or thalweg), in the municipality of Várzea Grande, MT. APD classification is also made possible of these dams and, thus, presents a procedure (or protocol) for the APD classification of dams located in the same body of water (or thalweg).
To analyse the negative influence of a dam failure in other dams located in the same watercourse, the “Simplified Methodology to Define the Classification Flood Zone of Associated Potential Damage of a Dam” was used. This methodology is currently used by the National Water and Sanitation Agency to classify dams within the competence. It is a methodology developed at the National Laboratory for Civil Engineering in Portugal for the National Water and Sanitation Agency, which generates a reference area or polygon for APD estimation. The methodology assumes that the available data from both the dams and the relief do not allow the accurate modelling of the failure. Thus, the appropriate methodology was simplified so as to use the Shuttle Radar Topography Mission (SRTM) as a digital elevation model and a minimum of input data without describing the geometry of both the dam and the downstream flow channel.
Therefore, the objective of this area is only to delimit the area of analysis to classify the APD. It is similar to a flooded area; however, we cannot understand it as an exact flood area, due to insufficient data precision, especially the relief data (30 m SRTM). It is limited to being a reference on which the public agent, or the dam safety supervisory body, can be based to prioritise its performance [15].
According to [15], the methodology (considering the area downstream of the dam and some cross sections, reference and control) consists of the following procedures:
Empirical calculation of the length of the river to be modelled.
Verification of the adequacy of the determined limit, analysing the occupation and geomorphology of the valley downstream of the dam.
Calculation of the maximum flow associated with the dam failure.
Calculation of peak flows in each of the cross sections along the valley.
Comparison of the damped flow in each cross section along the valley with the maximum flow of the spillway.
Obtaining the altimetry of points along the cross sections.
Hydraulic calculation to estimate the maximum level of the failure wave in each of the cross sections.
Creation of the surface surrounding the failure wave.
Obtaining the polygon, for the APD classification.
Possible adoption of adjustments, to consider specific characteristics of the site.
To generate the area, it is necessary to use the ArcGis software. In the study, version 10.5 was used. In addition, the following additional data are required:
SRTM 30 m.
Reservoir volume (hm3).
Height of the dam (m).
Crowning quota (meters above mean sea level, m).
Satellite images.
The risk analysis of cascading failure of the dams (selected) occurred from thematic maps with the classification areas, where they were evaluated according to the aspects of the classification of the APD presented in [16], such as total volume of the reservoir; potential for loss of human life; environmental impact and socio-economic impact.
For the analysis, a case study was carried out using dams 1 (B1), dam 2 (B2) and dam 3 (B3) located in Ribeirão Esmeril, a municipality of Várzea Grande, Mato Grosso and presented in Figure 1.
Dams used to analyse the negative influence of dams located in the same watercourse.
The structures were built using homogeneous land as material, with priority use for aquaculture activity. These dams are registered with the Mato Grosso State Secretariat for the Environment Water Resource Superintendence. They were inspected in 2016 and have data collected in the field by technicians from the inspection body (SEMA-MT).
The location and height of the dams were obtained from the Mato Grosso State Secretariat for the Environment survey report. The volume was estimated from the wetland and height of the dam. Additional information on the dams includes: foundation on soil; embankment dam formed of compacted earth, material homogeneous; construction date, unknown; volume of dam 1 = 0.24 hm3; volume of dam 2 = 0.50 hm3; volume of dam 3 = 0.39 hm3; height of dam 1 = 2.7 m; height of dam 2 = 4.8 m; and height of dam 3 = 6.3 m. The crest of the dams was obtained from Google Earth. The input data used in the simulations are shown in Table 2.
Simulation | Scenario | Estimated volume (hm3) | H (m) | Crowning quota (m) |
---|---|---|---|---|
S1 | Isolated failure of B1 dam | 0.24 | 2.7 | 175 |
S2 | Isolated failure of B2 dam | 0.50 | 4.8 | 174 |
S3 | Isolated failure of B3 dam | 0.39 | 6.3 | 173 |
S4 | Failure of B2 and B3 dams | 0.89 | 6.3 | 173 |
S5 | Failure of B1, B2 and B3 dams | 1.13 | 6.3 | 173 |
Input data for generating the APD classification area, considering different scenarios.
In the simulations, to analyse the negative influence of dams located in the same watercourse, some scenarios were considered, where they could occur:
Isolated failure of each of the dams, according to the recommendations of [15].
Cascade failure of dams B2 and B3, where the initial failure occurs in dam B2, but given the limitations of the application, it is considered as occurring in dam B3, adding the volumes of water stored in the two structures (volume of dam B2 added to the volume of the B3 dam), as if it were only in the B3.
Failure of the three dams. In this case (given the limitations of the methodology), the modelled failure occurs in dam B3 and the volume considered in the simulation was the sum of the volumes of the three dams.
As the methodology for generating the classification area can only consider data from only one dam, for the cascade failure scenarios (simulation S4 and S5), the simulation was started at the last dam where the failure would occur.
Therefore, the height and crown height data used in the S4 and S5 simulations were the data from the B3 dam, while the volume used was the sum of the three reservoirs.
Figure 2 shows the classification area considering only the B1 failure.
Area generated considering simulation 1.
By analysing the isolated areas and the values of the maximum levels obtained, it can be observed that the failure of the upstream dam (dam B1) would probably cause the failure of dams B2 and B3, as the maximum levels obtained in the simulation of dam B1 in the sections of dams B2 and B3 are 175.32 m and 174.33 m, respectively. The heights of the crest of these dams are 174 m and 173 m, respectively.
Thus, by the simulation, the water could pass over the crest of these dams, which would probably cause a sequential failure by overtopping.
A similar situation occurred with the maximum levels of the isolated failure simulation of dam B2. In this case, the wave would probably cause water to pass over dam B3, according to the simulation, as the maximum height of the flood wave in the section where dam B3 is located is 174.89 m and the crest level of that dam is 173 m.
Figure 3 shows that the areas generated by the cascade failures are larger than the areas considering the isolated dam failures.
Area caused by the hypothetical failure of dams B1, B2, and B3.
This demonstrates the need for a differentiated regularisation procedure for these dams, since they must be classified together, as they generate greater negative consequences, that is, possible loss of life, damage to the environment and socio-economic losses.
In the case studied, according to the simulation of the hypothetical failure area, a possible failure could affect housing and the federal highway located downstream of the dams, as well as fish farming ponds, also generating economic impacts.
Considering the dam classification separately, all are classified with HIGH APD, according to [9]. Following the classification matrix regarding the APD of resolutions [8, 16], the area in the three cases passes through housing where there is permanent occupation, a federal highway and aquaculture tanks, as shown in Figure 4, totalling APD equal to 17 (a = 1, b = 12, c = 1, and d = 3, in the evaluation table).
Detail of the housing, aquaculture tanks and road section present in the area, considering the failure of dams B1, B2, and B3.
According to [9], there was guidance to already consider HIGH APD, in case any item of the “Conservation State” is greater than or equal to “10”.
The same occurred considering the failure of the cascade dams, both for the scenario of the failure of dams B2 and B3 and for the failure scenario of the three dams.
It is important to mention that the program itself calculates the length of the river to be modelled. For all simulations, the limit distance calculated by the program was approximately 7 km.
Therefore, all the generated flood areas are about 7 km long and, consequently, would appear (unconfirmed) that they would probably not reach the Cuiabá river.
However, it is believed that if the simulation were carried out for a greater distance, the area would reach the main body of water. However, it is also believed that the Cuiabá river itself (as it is larger) would be able to lessen this cascade failure flood wave.
From these simulations, a procedure to analyse the APD of cascade dams was devised, which consists of the following steps:
Carry out the simulation considering the isolated dam failure.
Check if there would be a situation of overtopping of the downstream dams, caused by the upstream dams, considering the maximum elevation values of the classification area.
Carry out the simulation considering the extreme case of cascading failure of all dams. In this case, the simulation must use data from the last downstream dam (height and height of the crest), but with the total volume of the three dams.
Analyse the APD classification criteria presented in [16], based on the APD classification area generated by the simulation that considers the extreme case of a cascade failure.
Check the APD rating (high, medium or low) as per Table 1 from [9], showed in item Theoretical background.
The existence of numerous small dams and many in cascade spread throughout the state of Mato Grosso is a risk of accidents and catastrophes, related to the safety of dams. From the way they originated and live day to day (lack of design, inadequate construction, lack of knowledge of technique and legislation, lack of maintenance, lack of resources, etc.), there is uncertainty about their safety.
Thus, the analysis of the negative influence of dams located in the same watercourse is extremely important so that the inspection bodies of dam safety are aware of the possible impacts of dams in cascade and not just sequential when there would be no failure in the “domino effect”.
The development of related studies and their regulation will make it mandatory for designers to provide and submit to the supervisory body: studies, reports and action plans, necessary to guarantee the safety of these dams, as well as immediate resilience activities, thus guaranteeing the safety of the population and the environment.
Both the authors wish to express their thanks to the Institute of Applied Economic Research (IPEA) and National Water and Sanitation Agency (ANA) for the scholarship to researchers, through the Project “Aperfeiçoamento de Ferramentas Estaduais de Gestão de Recursos Hídricos no Âmbito do Progestão”. They are also thankful to the State Environment Secretary, Mato Grosso State (SEMA-MT) for the technical support, support for field activities, as well as for providing and authorising the use and dissemination of data. The support of the Federal University of Mato Grosso – “Edital de Apoio à Pesquisa (2021)”.
The authors declare no conflict of interest.
A cascade dam system poses more hazards for downstream life and structures, when compared with a single dam located on a river. Therefore, there is a need to develop differentiated procedures to classify and regulate these dams. In the state of Mato Grosso (MT), Brazil, it is common to find multipurpose dams, which can be considered as a cascade, when a dam failure causes adverse effects in downstream dams. The objective of the study is to analyse the possibility of dam failure located in the cascade system operated by the municipality of Várzea Grande, MT by the Associated Potential Damage (APD) classification used throughout the country. In order to do this, the specification namely “Simplified Methodology to Define the Classification Flood Zone of Associated Potential Damage of a Dam” developed by the National Laboratory for Civil Engineering in Portugal (LNEC in Portuguese) was utilised. This specification was adapted by the National Water and Sanitation Agency (ANA in Portuguese) in Brazil. In the case study, there are three dams (Dam 1, Dam 2 and Dam 3) in the cascade system. Dam 1 can cause overtopping problem for Dam 2 and Dam 3. According to APD classification, dams considered for the study are categorised as “high dam”.
',reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/1084630",risUrl:"/chapter/ris/1084630",signatures:"Angélica Luciana Barros de Campos, Ruben Jose Ramos Cardia and Welitom Ttatom Pereira da Silva",book:{id:"11187",type:"book",title:"Special Topics in Dam Engineering",subtitle:null,fullTitle:"Special Topics in Dam Engineering",slug:null,publishedDate:null,bookSignature:"Prof. Hasan Tosun",coverURL:"https://cdn.intechopen.com/books/images_new/11187.jpg",licenceType:"CC BY 3.0",editedByType:null,isbn:"978-1-80355-978-0",printIsbn:"978-1-80355-979-7",pdfIsbn:"978-1-80355-980-3",isAvailableForWebshopOrdering:!1,editors:[{id:"79083",title:"Dr.",name:"Hasan",middleName:null,surname:"Tosun",slug:"hasan-tosun",fullName:"Hasan Tosun"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"330069",title:"Prof.",name:"Welitom Ttatom",middleName:"Ttatom Pereira Da",surname:"Pereira da Silva",fullName:"Welitom Ttatom Pereira da Silva",slug:"welitom-ttatom-pereira-da-silva",email:"wttatom@gmail.com",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0033Y000030zSDpQAM/ProfilePicture%202021-12-22%2002%3A45%3A11.218",institution:null},{id:"450806",title:"M.Sc.",name:"Angélica Luciana Barros",middleName:null,surname:"de Campos",fullName:"Angélica Luciana Barros de Campos",slug:"angelica-luciana-barros-de-campos",email:"angelbarrosdecampos@gmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"450807",title:"B.Sc.",name:"Ruben Jose Ramos",middleName:null,surname:"Cardia",fullName:"Ruben Jose Ramos Cardia",slug:"ruben-jose-ramos-cardia",email:"rjcardia@gmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Theoretical background",level:"1"},{id:"sec_2_2",title:"2.1 National dam safety policy",level:"2"},{id:"sec_3_2",title:"2.2 Dam safety plan",level:"2"},{id:"sec_4_2",title:"2.3 Dam classification",level:"2"},{id:"sec_5_2",title:"2.4 Situation of cascade dams",level:"2"},{id:"sec_7",title:"3. Methodology",level:"1"},{id:"sec_8",title:"4. Results and discussion",level:"1"},{id:"sec_9",title:"5. Conclusion",level:"1"},{id:"sec_10",title:"Acknowledgments",level:"1"},{id:"sec_10",title:"Conflict of interest",level:"1"}],chapterReferences:[{id:"B1",body:'IntechOpen - where academia and industry create content with global impact
",metaTitle:"Team",metaDescription:"Advancing discovery in Open Access for the scientists by the scientist",metaKeywords:null,canonicalURL:"page/team",contentRaw:'[{"type":"htmlEditorComponent","content":"Our business values are based on those any scientist applies to their research. We have created a culture of respect and collaboration within a relaxed, friendly and progressive atmosphere, while maintaining academic rigour.
\\n\\nCo-founded by Alex Lazinica and Vedran Kordic: “We are passionate about the advancement of science. As Ph.D. researchers in Vienna, we found it difficult to access the scholarly research we needed. We created IntechOpen with the specific aim of putting the academic needs of the global research community before the business interests of publishers. Our Team is now a global one and includes highly-renowned scientists and publishers, as well as experts in disseminating your research.”
\\n\\nBut, one thing we have in common is -- we are all scientists at heart!
\\n\\nSara Uhac, COO
\\n\\nSara Uhac was appointed Managing Director of IntechOpen at the beginning of 2014. She directs and controls the company’s operations. Sara joined IntechOpen in 2010 as Head of Journal Publishing, a new strategically underdeveloped department at that time. After obtaining a Master's degree in Media Management, she completed her Ph.D. at the University of Lugano, Switzerland. She holds a BA in Financial Market Management from the Bocconi University in Milan, Italy, where she started her career in the American publishing house Condé Nast and further collaborated with the UK-based publishing company Time Out. Sara was awarded a professional degree in Publishing from Yale University (2012). She is a member of the professional branch association of "Publishers, Designers and Graphic Artists" at the Croatian Chamber of Commerce.
\\n\\nAdrian Assad De Marco
\\n\\nAdrian Assad De Marco joined the company as a Director in 2017. With his extensive experience in management, acquired while working for regional and global leaders, he took over direction and control of all the company's publishing processes. Adrian holds a degree in Economy and Management from the University of Zagreb, School of Economics, Croatia. A former sportsman, he continually strives to develop his skills through professional courses and specializations such as NLP (Neuro-linguistic programming).
\\n\\nDr Alex Lazinica
\\n\\nAlex Lazinica is co-founder and Board member of IntechOpen. After obtaining a Master's degree in Mechanical Engineering, he continued his Ph.D. in Robotics at the Vienna University of Technology. There, he worked as a robotics researcher with the university's Intelligent Manufacturing Systems Group, as well as a guest researcher at various European universities, including the Swiss Federal Institute of Technology Lausanne (EPFL). During this time he published more than 20 scientific papers, gave presentations, served as a reviewer for major robotic journals and conferences and, most importantly, co-founded and built the International Journal of Advanced Robotic Systems, the world's first Open Access journal in the field of robotics. Starting this journal was a pivotal point in his career since it proved to be the pathway to the foundation of IntechOpen with its focus on addressing academic researchers’ needs. Alex personifies many of IntechOpen´s key values, including the commitment to developing mutual trust, openness, and a spirit of entrepreneurialism. Today, his focus is on defining the growth and development strategy for the company.
\\n"}]'},components:[{type:"htmlEditorComponent",content:"Our business values are based on those any scientist applies to their research. We have created a culture of respect and collaboration within a relaxed, friendly and progressive atmosphere, while maintaining academic rigour.
\n\nCo-founded by Alex Lazinica and Vedran Kordic: “We are passionate about the advancement of science. As Ph.D. researchers in Vienna, we found it difficult to access the scholarly research we needed. We created IntechOpen with the specific aim of putting the academic needs of the global research community before the business interests of publishers. Our Team is now a global one and includes highly-renowned scientists and publishers, as well as experts in disseminating your research.”
\n\nBut, one thing we have in common is -- we are all scientists at heart!
\n\nSara Uhac, COO
\n\nSara Uhac was appointed Managing Director of IntechOpen at the beginning of 2014. She directs and controls the company’s operations. Sara joined IntechOpen in 2010 as Head of Journal Publishing, a new strategically underdeveloped department at that time. After obtaining a Master's degree in Media Management, she completed her Ph.D. at the University of Lugano, Switzerland. She holds a BA in Financial Market Management from the Bocconi University in Milan, Italy, where she started her career in the American publishing house Condé Nast and further collaborated with the UK-based publishing company Time Out. Sara was awarded a professional degree in Publishing from Yale University (2012). She is a member of the professional branch association of "Publishers, Designers and Graphic Artists" at the Croatian Chamber of Commerce.
\n\nAdrian Assad De Marco
\n\nAdrian Assad De Marco joined the company as a Director in 2017. With his extensive experience in management, acquired while working for regional and global leaders, he took over direction and control of all the company's publishing processes. Adrian holds a degree in Economy and Management from the University of Zagreb, School of Economics, Croatia. A former sportsman, he continually strives to develop his skills through professional courses and specializations such as NLP (Neuro-linguistic programming).
\n\nDr Alex Lazinica
\n\nAlex Lazinica is co-founder and Board member of IntechOpen. After obtaining a Master's degree in Mechanical Engineering, he continued his Ph.D. in Robotics at the Vienna University of Technology. There, he worked as a robotics researcher with the university's Intelligent Manufacturing Systems Group, as well as a guest researcher at various European universities, including the Swiss Federal Institute of Technology Lausanne (EPFL). During this time he published more than 20 scientific papers, gave presentations, served as a reviewer for major robotic journals and conferences and, most importantly, co-founded and built the International Journal of Advanced Robotic Systems, the world's first Open Access journal in the field of robotics. Starting this journal was a pivotal point in his career since it proved to be the pathway to the foundation of IntechOpen with its focus on addressing academic researchers’ needs. Alex personifies many of IntechOpen´s key values, including the commitment to developing mutual trust, openness, and a spirit of entrepreneurialism. Today, his focus is on defining the growth and development strategy for the company.
\n"}]},successStories:{items:[]},authorsAndEditors:{filterParams:{},profiles:[{id:"396",title:"Dr.",name:"Vedran",middleName:null,surname:"Kordic",slug:"vedran-kordic",fullName:"Vedran Kordic",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/396/images/7281_n.png",biography:"After obtaining his Master's degree in Mechanical Engineering he continued his education at the Vienna University of Technology where he obtained his PhD degree in 2004. He worked as a researcher at the Automation and Control Institute, Faculty of Electrical Engineering, Vienna University of Technology until 2008. His studies in robotics lead him not only to a PhD degree but also inspired him to co-found and build the International Journal of Advanced Robotic Systems - world's first Open Access journal in the field of robotics.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"441",title:"Ph.D.",name:"Jaekyu",middleName:null,surname:"Park",slug:"jaekyu-park",fullName:"Jaekyu Park",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/441/images/1881_n.jpg",biography:null,institutionString:null,institution:{name:"LG Corporation (South Korea)",country:{name:"Korea, South"}}},{id:"465",title:"Dr.",name:"Christian",middleName:null,surname:"Martens",slug:"christian-martens",fullName:"Christian Martens",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Rheinmetall (Germany)",country:{name:"Germany"}}},{id:"479",title:"Dr.",name:"Valentina",middleName:null,surname:"Colla",slug:"valentina-colla",fullName:"Valentina Colla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/479/images/358_n.jpg",biography:null,institutionString:null,institution:{name:"Sant'Anna School of Advanced Studies",country:{name:"Italy"}}},{id:"494",title:"PhD",name:"Loris",middleName:null,surname:"Nanni",slug:"loris-nanni",fullName:"Loris Nanni",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/494/images/system/494.jpg",biography:"Loris Nanni received his Master Degree cum laude on June-2002 from the University of Bologna, and the April 26th 2006 he received his Ph.D. in Computer Engineering at DEIS, University of Bologna. On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. His research interests include pattern recognition, bioinformatics, and biometric systems (fingerprint classification and recognition, signature verification, face recognition).",institutionString:null,institution:null},{id:"496",title:"Dr.",name:"Carlos",middleName:null,surname:"Leon",slug:"carlos-leon",fullName:"Carlos Leon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Seville",country:{name:"Spain"}}},{id:"512",title:"Dr.",name:"Dayang",middleName:null,surname:"Jawawi",slug:"dayang-jawawi",fullName:"Dayang Jawawi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Technology Malaysia",country:{name:"Malaysia"}}},{id:"528",title:"Dr.",name:"Kresimir",middleName:null,surname:"Delac",slug:"kresimir-delac",fullName:"Kresimir Delac",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/528/images/system/528.jpg",biography:"K. Delac received his B.Sc.E.E. degree in 2003 and is currentlypursuing a Ph.D. degree at the University of Zagreb, Faculty of Electrical Engineering andComputing. His current research interests are digital image analysis, pattern recognition andbiometrics.",institutionString:null,institution:{name:"University of Zagreb",country:{name:"Croatia"}}},{id:"557",title:"Dr.",name:"Andon",middleName:"Venelinov",surname:"Topalov",slug:"andon-topalov",fullName:"Andon Topalov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/557/images/1927_n.jpg",biography:"Dr. Andon V. Topalov received the MSc degree in Control Engineering from the Faculty of Information Systems, Technologies, and Automation at Moscow State University of Civil Engineering (MGGU) in 1979. He then received his PhD degree in Control Engineering from the Department of Automation and Remote Control at Moscow State Mining University (MGSU), Moscow, in 1984. From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. His current research interests are in the fields of intelligent control and robotics.",institutionString:null,institution:{name:"Technical University of Sofia",country:{name:"Bulgaria"}}},{id:"585",title:"Prof.",name:"Munir",middleName:null,surname:"Merdan",slug:"munir-merdan",fullName:"Munir Merdan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/585/images/system/585.jpg",biography:"Munir Merdan received the M.Sc. degree in mechanical engineering from the Technical University of Sarajevo, Bosnia and Herzegovina, in 2001, and the Ph.D. degree in electrical engineering from the Vienna University of Technology, Vienna, Austria, in 2009.Since 2005, he has been at the Automation and Control Institute, Vienna University of Technology, where he is currently a Senior Researcher. His research interests include the application of agent technology for achieving agile control in the manufacturing environment.",institutionString:null,institution:null},{id:"605",title:"Prof",name:"Dil",middleName:null,surname:"Hussain",slug:"dil-hussain",fullName:"Dil Hussain",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/605/images/system/605.jpg",biography:"Dr. Dil Muhammad Akbar Hussain is a professor of Electronics Engineering & Computer Science at the Department of Energy Technology, Aalborg University Denmark. Professor Akbar has a Master degree in Digital Electronics from Govt. College University, Lahore Pakistan and a P-hD degree in Control Engineering from the School of Engineering and Applied Sciences, University of Sussex United Kingdom. Aalborg University has Two Satellite Campuses, one in Copenhagen (Aalborg University Copenhagen) and the other in Esbjerg (Aalborg University Esbjerg).\n· He is a member of prestigious IEEE (Institute of Electrical and Electronics Engineers), and IAENG (International Association of Engineers) organizations. \n· He is the chief Editor of the Journal of Software Engineering.\n· He is the member of the Editorial Board of International Journal of Computer Science and Software Technology (IJCSST) and International Journal of Computer Engineering and Information Technology. \n· He is also the Editor of Communication in Computer and Information Science CCIS-20 by Springer.\n· Reviewer For Many Conferences\nHe is the lead person in making collaboration agreements between Aalborg University and many universities of Pakistan, for which the MOU’s (Memorandum of Understanding) have been signed.\nProfessor Akbar is working in Academia since 1990, he started his career as a Lab demonstrator/TA at the University of Sussex. After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. He has contributed in stochastic estimation of control area especially, in the Multiple Target Tracking and Interactive Multiple Model (IMM) research, Ball & Beam Control Problem, Robotics, Levitation Control. He has contributed in developing Algorithms for Fingerprint Matching, Computer Vision and Face Recognition. He has been supervising Pattern Recognition, Formal Languages and Distributed Processing projects for several years. He has reviewed many books on Management, Computer Science. Currently, he is an active and permanent reviewer for many international conferences and symposia and the program committee member for many international conferences.\nIn teaching he has taught the core computer science subjects like, Digital Design, Real Time Embedded System Programming, Operating Systems, Software Engineering, Data Structures, Databases, Compiler Construction. In the Engineering side, Digital Signal Processing, Computer Architecture, Electronics Devices, Digital Filtering and Engineering Management.\nApart from his Academic Interest and activities he loves sport especially, Cricket, Football, Snooker and Squash. He plays cricket for Esbjerg city in the second division team as an opener wicket keeper batsman. He is a very good player of squash but has not played squash since his arrival in Denmark.",institutionString:null,institution:null},{id:"611",title:"Prof.",name:"T",middleName:null,surname:"Nagarajan",slug:"t-nagarajan",fullName:"T Nagarajan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universiti Teknologi Petronas",country:{name:"Malaysia"}}}],filtersByRegion:[{group:"region",caption:"North America",value:1,count:13389},{group:"region",caption:"Middle and South America",value:2,count:11658},{group:"region",caption:"Africa",value:3,count:4168},{group:"region",caption:"Asia",value:4,count:22334},{group:"region",caption:"Australia and Oceania",value:5,count:2019},{group:"region",caption:"Europe",value:6,count:33642}],offset:12,limit:12,total:135275},chapterEmbeded:{data:{}},editorApplication:{success:null,errors:{}},ofsBooks:{filterParams:{hasNoEditors:"0",sort:"dateEndThirdStepPublish",topicId:"5,6,12,13,18"},books:[{type:"book",id:"11369",title:"RNA Viruses Infection",subtitle:null,isOpenForSubmission:!0,hash:"52f8a3a1486912beae40b34ac557fed3",slug:null,bookSignature:"Ph.D. Yogendra Shah",coverURL:"https://cdn.intechopen.com/books/images_new/11369.jpg",editedByType:null,editors:[{id:"278914",title:"Ph.D.",name:"Yogendra",surname:"Shah",slug:"yogendra-shah",fullName:"Yogendra Shah"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11610",title:"New Insights in Herbicide Science",subtitle:null,isOpenForSubmission:!0,hash:"eb3830b8176caf3d1fd52c32313c5168",slug:null,bookSignature:"Ph.D. Kassio Ferreira Mendes",coverURL:"https://cdn.intechopen.com/books/images_new/11610.jpg",editedByType:null,editors:[{id:"197720",title:"Ph.D.",name:"Kassio",surname:"Ferreira Mendes",slug:"kassio-ferreira-mendes",fullName:"Kassio Ferreira Mendes"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11793",title:"Production, Nutritional and Industrial Perspectives of Barley",subtitle:null,isOpenForSubmission:!0,hash:"996125d4599193b3b6b749f5d8aa3cb2",slug:null,bookSignature:"Dr. Farhan Saeed and Dr. Muhammad Afzaal",coverURL:"https://cdn.intechopen.com/books/images_new/11793.jpg",editedByType:null,editors:[{id:"192244",title:"Dr.",name:"Farhan",surname:"Saeed",slug:"farhan-saeed",fullName:"Farhan Saeed"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11810",title:"Animal Behavior - New Insights",subtitle:null,isOpenForSubmission:!0,hash:"db1dacc9284b2fc73f38fa985a586e15",slug:null,bookSignature:"Associate Prof. Volkan Gelen and Dr. Abdulsamed Kükürt",coverURL:"https://cdn.intechopen.com/books/images_new/11810.jpg",editedByType:null,editors:[{id:"178366",title:"Dr.",name:"Volkan",surname:"Gelen",slug:"volkan-gelen",fullName:"Volkan Gelen"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12157",title:"Rice Crops - Productivity, Quality and Sustainability",subtitle:null,isOpenForSubmission:!0,hash:"2a38bb2448f4516740db05ce746f08e3",slug:null,bookSignature:"Dr. Min Huang, Dr. Jiana Chen, Dr. Xiaowu Pan and Dr. Haiming Tang",coverURL:"https://cdn.intechopen.com/books/images_new/12157.jpg",editedByType:null,editors:[{id:"189829",title:"Dr.",name:"Min",surname:"Huang",slug:"min-huang",fullName:"Min Huang"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11788",title:"Plant Stress Responses and Defense Mechanisms",subtitle:null,isOpenForSubmission:!0,hash:"fd76ac80924e5a4d530ad0a1b54ca1f4",slug:null,bookSignature:"Dr. Saddam Hussain, Dr. Tahir Hussain Awan, Dr. Ejaz Waraich and Dr. Masood Iqbal Awan",coverURL:"https://cdn.intechopen.com/books/images_new/11788.jpg",editedByType:null,editors:[{id:"247858",title:"Dr.",name:"Saddam",surname:"Hussain",slug:"saddam-hussain",fullName:"Saddam Hussain"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11643",title:"Genetic Diversity - Recent Advances and Applications",subtitle:null,isOpenForSubmission:!0,hash:"0b1e679fcacdec2448603a66df71ccc7",slug:null,bookSignature:"Prof. Mahmut Çalışkan and Dr. Sevcan Aydin",coverURL:"https://cdn.intechopen.com/books/images_new/11643.jpg",editedByType:null,editors:[{id:"51528",title:"Prof.",name:"Mahmut",surname:"Çalışkan",slug:"mahmut-caliskan",fullName:"Mahmut Çalışkan"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11637",title:"Neuropsychology of Dementia",subtitle:null,isOpenForSubmission:!0,hash:"d40f707b9ef020bb202be89404f77a1e",slug:null,bookSignature:"Dr. Devendra Kumar, Prof. Sushil Kumar Singh and Dr. Ankit Ganeshpurkar",coverURL:"https://cdn.intechopen.com/books/images_new/11637.jpg",editedByType:null,editors:[{id:"454030",title:"Dr.",name:"Devendra",surname:"Kumar",slug:"devendra-kumar",fullName:"Devendra Kumar"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11624",title:"Agricultural Waste - New Insights",subtitle:null,isOpenForSubmission:!0,hash:"f86a9f720cc3ac0f1c385d0367ea89b9",slug:null,bookSignature:"Dr. Fiaz Ahmad and Prof. Muhammad Sultan",coverURL:"https://cdn.intechopen.com/books/images_new/11624.jpg",editedByType:null,editors:[{id:"338219",title:"Dr.",name:"Fiaz",surname:"Ahmad",slug:"fiaz-ahmad",fullName:"Fiaz Ahmad"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11784",title:"Bryophytes - The State of Knowledge in a World Under Climate Change",subtitle:null,isOpenForSubmission:!0,hash:"80743b2add35e11b09c10e6895a45831",slug:null,bookSignature:"Prof. Jair Putzke",coverURL:"https://cdn.intechopen.com/books/images_new/11784.jpg",editedByType:null,editors:[{id:"324930",title:"Prof.",name:"Jair",surname:"Putzke",slug:"jair-putzke",fullName:"Jair Putzke"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11642",title:"Food Preservation and Packaging - Recent Process and Technological Advancements",subtitle:null,isOpenForSubmission:!0,hash:"00f636e3012dc12ebb8713cb51d75a1f",slug:null,bookSignature:"Dr. Jaya Shankar Tumuluru",coverURL:"https://cdn.intechopen.com/books/images_new/11642.jpg",editedByType:null,editors:[{id:"95803",title:"Dr.",name:"Jaya Shankar",surname:"Tumuluru",slug:"jaya-shankar-tumuluru",fullName:"Jaya Shankar Tumuluru"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12332",title:"Resveratrol - Recent Advances, Application, and Therapeutic Potential",subtitle:null,isOpenForSubmission:!0,hash:"6c796885b34b6727cb8fb36badef827f",slug:null,bookSignature:"Dr. Ali Imran",coverURL:"https://cdn.intechopen.com/books/images_new/12332.jpg",editedByType:null,editors:[{id:"235082",title:"Dr.",name:"Ali",surname:"Imran",slug:"ali-imran",fullName:"Ali Imran"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],filtersByTopic:[{group:"topic",caption:"Agricultural and Biological Sciences",value:5,count:27},{group:"topic",caption:"Biochemistry, Genetics and Molecular Biology",value:6,count:7},{group:"topic",caption:"Business, Management and Economics",value:7,count:4},{group:"topic",caption:"Chemistry",value:8,count:16},{group:"topic",caption:"Computer and Information Science",value:9,count:18},{group:"topic",caption:"Earth and Planetary Sciences",value:10,count:8},{group:"topic",caption:"Engineering",value:11,count:42},{group:"topic",caption:"Environmental Sciences",value:12,count:5},{group:"topic",caption:"Immunology and Microbiology",value:13,count:8},{group:"topic",caption:"Materials Science",value:14,count:17},{group:"topic",caption:"Mathematics",value:15,count:9},{group:"topic",caption:"Medicine",value:16,count:68},{group:"topic",caption:"Nanotechnology and Nanomaterials",value:17,count:3},{group:"topic",caption:"Neuroscience",value:18,count:3},{group:"topic",caption:"Pharmacology, Toxicology and Pharmaceutical Science",value:19,count:6},{group:"topic",caption:"Physics",value:20,count:6},{group:"topic",caption:"Psychology",value:21,count:5},{group:"topic",caption:"Robotics",value:22,count:2},{group:"topic",caption:"Social Sciences",value:23,count:7},{group:"topic",caption:"Veterinary Medicine and Science",value:25,count:2}],offset:12,limit:12,total:50},popularBooks:{featuredBooks:[{type:"book",id:"7827",title:"Interpersonal Relationships",subtitle:null,isOpenForSubmission:!1,hash:"ebf41f4d17c75010eb3294cc8cac3d47",slug:"interpersonal-relationships",bookSignature:"Martha Peaslee Levine",coverURL:"https://cdn.intechopen.com/books/images_new/7827.jpg",editors:[{id:"186919",title:"Dr.",name:"Martha",middleName:null,surname:"Peaslee Levine",slug:"martha-peaslee-levine",fullName:"Martha Peaslee Levine"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10808",title:"Current Concepts in Dental Implantology",subtitle:"From Science to Clinical Research",isOpenForSubmission:!1,hash:"4af8830e463f89c57515c2da2b9777b0",slug:"current-concepts-in-dental-implantology-from-science-to-clinical-research",bookSignature:"Dragana Gabrić and Marko Vuletić",coverURL:"https://cdn.intechopen.com/books/images_new/10808.jpg",editors:[{id:"26946",title:"Prof.",name:"Dragana",middleName:null,surname:"Gabrić",slug:"dragana-gabric",fullName:"Dragana Gabrić"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10908",title:"Advances in Decision Making",subtitle:null,isOpenForSubmission:!1,hash:"126486f7f91e18e2e3539a32c38be7b1",slug:"advances-in-decision-making",bookSignature:"Fausto Pedro García Márquez",coverURL:"https://cdn.intechopen.com/books/images_new/10908.jpg",editors:[{id:"22844",title:"Prof.",name:"Fausto Pedro",middleName:null,surname:"García Márquez",slug:"fausto-pedro-garcia-marquez",fullName:"Fausto Pedro García Márquez"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10796",title:"Extracellular Vesicles",subtitle:"Role in Diseases, Pathogenesis and Therapy",isOpenForSubmission:!1,hash:"eb5407fcf93baff7bca3fae5640153a2",slug:"extracellular-vesicles-role-in-diseases-pathogenesis-and-therapy",bookSignature:"Manash K. Paul",coverURL:"https://cdn.intechopen.com/books/images_new/10796.jpg",editors:[{id:"319365",title:"Assistant Prof.",name:"Manash K.",middleName:null,surname:"Paul",slug:"manash-k.-paul",fullName:"Manash K. Paul"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11263",title:"Supply Chain",subtitle:"Recent Advances and New Perspectives in the Industry 4.0 Era",isOpenForSubmission:!1,hash:"aab634c9c1f9a692c1e9881d18e9c9b7",slug:"supply-chain-recent-advances-and-new-perspectives-in-the-industry-4-0-era",bookSignature:"Tamás Bányai, Ágota Bányai and Ireneusz Kaczmar",coverURL:"https://cdn.intechopen.com/books/images_new/11263.jpg",editors:[{id:"201248",title:"Dr.",name:"Tamás",middleName:null,surname:"Bányai",slug:"tamas-banyai",fullName:"Tamás Bányai"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10739",title:"Global Decline of Insects",subtitle:null,isOpenForSubmission:!1,hash:"543783652b9092962a8fa4bed38eeb17",slug:"global-decline-of-insects",bookSignature:"Hamadttu Abdel Farag El-Shafie",coverURL:"https://cdn.intechopen.com/books/images_new/10739.jpg",editors:[{id:"192142",title:"Dr.",name:"Hamadttu",middleName:null,surname:"Abdel Farag El-Shafie",slug:"hamadttu-abdel-farag-el-shafie",fullName:"Hamadttu Abdel Farag El-Shafie"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10911",title:"Higher Education",subtitle:"New Approaches to Accreditation, Digitalization, and Globalization in the Age of Covid",isOpenForSubmission:!1,hash:"223a02337498e535e967174c1f648fbc",slug:"higher-education-new-approaches-to-accreditation-digitalization-and-globalization-in-the-age-of-covid",bookSignature:"Lee Waller and Sharon Waller",coverURL:"https://cdn.intechopen.com/books/images_new/10911.jpg",editors:[{id:"263301",title:"Dr.",name:"Lee",middleName:null,surname:"Waller",slug:"lee-waller",fullName:"Lee Waller"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10669",title:"Corrosion",subtitle:"Fundamentals and Protection Mechanisms",isOpenForSubmission:!1,hash:"4a76d54f8a40fc2e7002a8d13fd617c1",slug:"corrosion-fundamentals-and-protection-mechanisms",bookSignature:"Fahmina Zafar, Anujit Ghosal and Eram Sharmin",coverURL:"https://cdn.intechopen.com/books/images_new/10669.jpg",editors:[{id:"89672",title:"Dr.",name:"Fahmina",middleName:null,surname:"Zafar",slug:"fahmina-zafar",fullName:"Fahmina Zafar"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"95",title:"Applications and Experiences of Quality Control",subtitle:null,isOpenForSubmission:!1,hash:"4bcb22b1eee68210a977a97d5a0f363a",slug:"applications-and-experiences-of-quality-control",bookSignature:"Ognyan Ivanov",coverURL:"https://cdn.intechopen.com/books/images_new/95.jpg",editors:[{id:"22230",title:"Prof.",name:"Ognyan",middleName:null,surname:"Ivanov",slug:"ognyan-ivanov",fullName:"Ognyan Ivanov"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"2160",title:"MATLAB",subtitle:"A Fundamental Tool for Scientific Computing and Engineering Applications - Volume 1",isOpenForSubmission:!1,hash:"dd9c658341fbd264ed4f8d9e6aa8ca29",slug:"matlab-a-fundamental-tool-for-scientific-computing-and-engineering-applications-volume-1",bookSignature:"Vasilios N. Katsikis",coverURL:"https://cdn.intechopen.com/books/images_new/2160.jpg",editors:[{id:"12289",title:"Prof.",name:"Vasilios",middleName:"N.",surname:"Katsikis",slug:"vasilios-katsikis",fullName:"Vasilios Katsikis"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"3560",title:"Advances in Landscape Architecture",subtitle:null,isOpenForSubmission:!1,hash:"a20614517ec5f7e91188fe8e42832138",slug:"advances-in-landscape-architecture",bookSignature:"Murat Özyavuz",coverURL:"https://cdn.intechopen.com/books/images_new/3560.jpg",editors:[{id:"93073",title:"Dr.",name:"Murat",middleName:null,surname:"Ozyavuz",slug:"murat-ozyavuz",fullName:"Murat Ozyavuz"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"3568",title:"Recent Advances in Plant in vitro Culture",subtitle:null,isOpenForSubmission:!1,hash:"830bbb601742c85a3fb0eeafe1454c43",slug:"recent-advances-in-plant-in-vitro-culture",bookSignature:"Annarita Leva and Laura M. R. Rinaldi",coverURL:"https://cdn.intechopen.com/books/images_new/3568.jpg",editors:[{id:"142145",title:"Dr.",name:"Annarita",middleName:null,surname:"Leva",slug:"annarita-leva",fullName:"Annarita Leva"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],offset:12,limit:12,total:4798},hotBookTopics:{hotBooks:[],offset:0,limit:12,total:null},publish:{},publishingProposal:{success:null,errors:{}},books:{featuredBooks:[{type:"book",id:"7827",title:"Interpersonal Relationships",subtitle:null,isOpenForSubmission:!1,hash:"ebf41f4d17c75010eb3294cc8cac3d47",slug:"interpersonal-relationships",bookSignature:"Martha Peaslee Levine",coverURL:"https://cdn.intechopen.com/books/images_new/7827.jpg",publishedDate:"July 27th 2022",numberOfDownloads:7107,editors:[{id:"186919",title:"Dr.",name:"Martha",middleName:null,surname:"Peaslee Levine",slug:"martha-peaslee-levine",fullName:"Martha Peaslee Levine"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10808",title:"Current Concepts in Dental Implantology",subtitle:"From Science to Clinical Research",isOpenForSubmission:!1,hash:"4af8830e463f89c57515c2da2b9777b0",slug:"current-concepts-in-dental-implantology-from-science-to-clinical-research",bookSignature:"Dragana Gabrić and Marko Vuletić",coverURL:"https://cdn.intechopen.com/books/images_new/10808.jpg",publishedDate:"July 27th 2022",numberOfDownloads:1955,editors:[{id:"26946",title:"Prof.",name:"Dragana",middleName:null,surname:"Gabrić",slug:"dragana-gabric",fullName:"Dragana Gabrić"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10908",title:"Advances in Decision Making",subtitle:null,isOpenForSubmission:!1,hash:"126486f7f91e18e2e3539a32c38be7b1",slug:"advances-in-decision-making",bookSignature:"Fausto Pedro García Márquez",coverURL:"https://cdn.intechopen.com/books/images_new/10908.jpg",publishedDate:"July 27th 2022",numberOfDownloads:1452,editors:[{id:"22844",title:"Prof.",name:"Fausto Pedro",middleName:null,surname:"García Márquez",slug:"fausto-pedro-garcia-marquez",fullName:"Fausto Pedro García Márquez"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10796",title:"Extracellular Vesicles",subtitle:"Role in Diseases, Pathogenesis and Therapy",isOpenForSubmission:!1,hash:"eb5407fcf93baff7bca3fae5640153a2",slug:"extracellular-vesicles-role-in-diseases-pathogenesis-and-therapy",bookSignature:"Manash K. Paul",coverURL:"https://cdn.intechopen.com/books/images_new/10796.jpg",publishedDate:"July 20th 2022",numberOfDownloads:2289,editors:[{id:"319365",title:"Assistant Prof.",name:"Manash K.",middleName:null,surname:"Paul",slug:"manash-k.-paul",fullName:"Manash K. Paul"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11263",title:"Supply Chain",subtitle:"Recent Advances and New Perspectives in the Industry 4.0 Era",isOpenForSubmission:!1,hash:"aab634c9c1f9a692c1e9881d18e9c9b7",slug:"supply-chain-recent-advances-and-new-perspectives-in-the-industry-4-0-era",bookSignature:"Tamás Bányai, Ágota Bányai and Ireneusz Kaczmar",coverURL:"https://cdn.intechopen.com/books/images_new/11263.jpg",publishedDate:"July 27th 2022",numberOfDownloads:888,editors:[{id:"201248",title:"Dr.",name:"Tamás",middleName:null,surname:"Bányai",slug:"tamas-banyai",fullName:"Tamás Bányai"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10739",title:"Global Decline of Insects",subtitle:null,isOpenForSubmission:!1,hash:"543783652b9092962a8fa4bed38eeb17",slug:"global-decline-of-insects",bookSignature:"Hamadttu Abdel Farag El-Shafie",coverURL:"https://cdn.intechopen.com/books/images_new/10739.jpg",publishedDate:"July 20th 2022",numberOfDownloads:1566,editors:[{id:"192142",title:"Dr.",name:"Hamadttu",middleName:null,surname:"Abdel Farag El-Shafie",slug:"hamadttu-abdel-farag-el-shafie",fullName:"Hamadttu Abdel Farag El-Shafie"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10911",title:"Higher Education",subtitle:"New Approaches to Accreditation, Digitalization, and Globalization in the Age of Covid",isOpenForSubmission:!1,hash:"223a02337498e535e967174c1f648fbc",slug:"higher-education-new-approaches-to-accreditation-digitalization-and-globalization-in-the-age-of-covid",bookSignature:"Lee Waller and Sharon Waller",coverURL:"https://cdn.intechopen.com/books/images_new/10911.jpg",publishedDate:"July 13th 2022",numberOfDownloads:2054,editors:[{id:"263301",title:"Dr.",name:"Lee",middleName:null,surname:"Waller",slug:"lee-waller",fullName:"Lee Waller"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10669",title:"Corrosion",subtitle:"Fundamentals and Protection Mechanisms",isOpenForSubmission:!1,hash:"4a76d54f8a40fc2e7002a8d13fd617c1",slug:"corrosion-fundamentals-and-protection-mechanisms",bookSignature:"Fahmina Zafar, Anujit Ghosal and Eram Sharmin",coverURL:"https://cdn.intechopen.com/books/images_new/10669.jpg",publishedDate:"July 27th 2022",numberOfDownloads:780,editors:[{id:"89672",title:"Dr.",name:"Fahmina",middleName:null,surname:"Zafar",slug:"fahmina-zafar",fullName:"Fahmina Zafar"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"95",title:"Applications and Experiences of Quality Control",subtitle:null,isOpenForSubmission:!1,hash:"4bcb22b1eee68210a977a97d5a0f363a",slug:"applications-and-experiences-of-quality-control",bookSignature:"Ognyan Ivanov",coverURL:"https://cdn.intechopen.com/books/images_new/95.jpg",publishedDate:"April 26th 2011",numberOfDownloads:318480,editors:[{id:"22230",title:"Prof.",name:"Ognyan",middleName:null,surname:"Ivanov",slug:"ognyan-ivanov",fullName:"Ognyan Ivanov"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"2160",title:"MATLAB",subtitle:"A Fundamental Tool for Scientific Computing and Engineering Applications - Volume 1",isOpenForSubmission:!1,hash:"dd9c658341fbd264ed4f8d9e6aa8ca29",slug:"matlab-a-fundamental-tool-for-scientific-computing-and-engineering-applications-volume-1",bookSignature:"Vasilios N. Katsikis",coverURL:"https://cdn.intechopen.com/books/images_new/2160.jpg",publishedDate:"September 26th 2012",numberOfDownloads:271760,editors:[{id:"12289",title:"Prof.",name:"Vasilios",middleName:"N.",surname:"Katsikis",slug:"vasilios-katsikis",fullName:"Vasilios Katsikis"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],latestBooks:[{type:"book",id:"10808",title:"Current Concepts in Dental Implantology",subtitle:"From Science to Clinical Research",isOpenForSubmission:!1,hash:"4af8830e463f89c57515c2da2b9777b0",slug:"current-concepts-in-dental-implantology-from-science-to-clinical-research",bookSignature:"Dragana Gabrić and Marko Vuletić",coverURL:"https://cdn.intechopen.com/books/images_new/10808.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"26946",title:"Prof.",name:"Dragana",middleName:null,surname:"Gabrić",slug:"dragana-gabric",fullName:"Dragana Gabrić"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11328",title:"Botulinum Toxin",subtitle:"Recent Topics and Applications",isOpenForSubmission:!1,hash:"7dd05a316001cef143e209eda51387a7",slug:"botulinum-toxin-recent-topics-and-applications",bookSignature:"Suna Sabuncuoglu",coverURL:"https://cdn.intechopen.com/books/images_new/11328.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"270856",title:"Associate Prof.",name:"Suna",middleName:null,surname:"Sabuncuoglu",slug:"suna-sabuncuoglu",fullName:"Suna Sabuncuoglu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11085",title:"Polycystic Ovary Syndrome",subtitle:"Functional Investigation and Clinical Application",isOpenForSubmission:!1,hash:"3066dd3ff29e1fac072fd60b08d4d3e7",slug:"polycystic-ovary-syndrome-functional-investigation-and-clinical-application",bookSignature:"Zhengchao Wang",coverURL:"https://cdn.intechopen.com/books/images_new/11085.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"204883",title:"Dr.",name:"Zhengchao",middleName:null,surname:"Wang",slug:"zhengchao-wang",fullName:"Zhengchao Wang"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10833",title:"Tumor Angiogenesis and Modulators",subtitle:null,isOpenForSubmission:!1,hash:"f29b575c46128b2da061ef7f9bd1070b",slug:"tumor-angiogenesis-and-modulators",bookSignature:"Ke Xu",coverURL:"https://cdn.intechopen.com/books/images_new/10833.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"59529",title:"Dr.",name:"Ke",middleName:null,surname:"Xu",slug:"ke-xu",fullName:"Ke Xu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11356",title:"Molecular Cloning",subtitle:null,isOpenForSubmission:!1,hash:"671c629dd86e97f0fb467b9e70e92296",slug:"molecular-cloning",bookSignature:"Sadık Dincer, Hatice Aysun Mercimek Takcı and Melis Sumengen Ozdenef",coverURL:"https://cdn.intechopen.com/books/images_new/11356.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"188141",title:"Prof.",name:"Sadik",middleName:null,surname:"Dincer",slug:"sadik-dincer",fullName:"Sadik Dincer"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7827",title:"Interpersonal Relationships",subtitle:null,isOpenForSubmission:!1,hash:"ebf41f4d17c75010eb3294cc8cac3d47",slug:"interpersonal-relationships",bookSignature:"Martha Peaslee Levine",coverURL:"https://cdn.intechopen.com/books/images_new/7827.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"186919",title:"Dr.",name:"Martha",middleName:null,surname:"Peaslee Levine",slug:"martha-peaslee-levine",fullName:"Martha Peaslee Levine"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10908",title:"Advances in Decision Making",subtitle:null,isOpenForSubmission:!1,hash:"126486f7f91e18e2e3539a32c38be7b1",slug:"advances-in-decision-making",bookSignature:"Fausto Pedro García Márquez",coverURL:"https://cdn.intechopen.com/books/images_new/10908.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"22844",title:"Prof.",name:"Fausto Pedro",middleName:null,surname:"García Márquez",slug:"fausto-pedro-garcia-marquez",fullName:"Fausto Pedro García Márquez"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10669",title:"Corrosion",subtitle:"Fundamentals and Protection Mechanisms",isOpenForSubmission:!1,hash:"4a76d54f8a40fc2e7002a8d13fd617c1",slug:"corrosion-fundamentals-and-protection-mechanisms",bookSignature:"Fahmina Zafar, Anujit Ghosal and Eram Sharmin",coverURL:"https://cdn.intechopen.com/books/images_new/10669.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"89672",title:"Dr.",name:"Fahmina",middleName:null,surname:"Zafar",slug:"fahmina-zafar",fullName:"Fahmina Zafar"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10677",title:"Advanced Topics of Topology",subtitle:null,isOpenForSubmission:!1,hash:"bf964c52f9e653fac20a7fcab58070e5",slug:"advanced-topics-of-topology",bookSignature:"Francisco Bulnes",coverURL:"https://cdn.intechopen.com/books/images_new/10677.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"92918",title:"Dr.",name:"Francisco",middleName:null,surname:"Bulnes",slug:"francisco-bulnes",fullName:"Francisco Bulnes"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11195",title:"Recent Advances in Biometrics",subtitle:null,isOpenForSubmission:!1,hash:"2d32e33e0f499cb5241734bb75dd2a83",slug:"recent-advances-in-biometrics",bookSignature:"Muhammad Sarfraz",coverURL:"https://cdn.intechopen.com/books/images_new/11195.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},subject:{topic:{id:"349",title:"Agrobiology",slug:"agrobiology",parent:{id:"41",title:"Plant Biology",slug:"agricultural-and-biological-sciences-plant-biology"},numberOfBooks:5,numberOfSeries:0,numberOfAuthorsAndEditors:136,numberOfWosCitations:154,numberOfCrossrefCitations:115,numberOfDimensionsCitations:308,videoUrl:null,fallbackUrl:null,description:null},booksByTopicFilter:{topicId:"349",sort:"-publishedDate",limit:12,offset:0},booksByTopicCollection:[{type:"book",id:"9684",title:"Cassava",subtitle:"Biology, Production, and Use",isOpenForSubmission:!1,hash:"1dfb68fa31006e91fa3995d804e361c1",slug:"cassava-biology-production-and-use",bookSignature:"Andri Frediansyah",coverURL:"https://cdn.intechopen.com/books/images_new/9684.jpg",editedByType:"Edited by",editors:[{id:"210767",title:"Dr.",name:"Andri",middleName:null,surname:"Frediansyah",slug:"andri-frediansyah",fullName:"Andri Frediansyah"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8954",title:"Biostimulants in Plant Science",subtitle:null,isOpenForSubmission:!1,hash:"ac0eb3328820cca42cb7d6cdbfca4ec2",slug:"biostimulants-in-plant-science",bookSignature:"Seyed Mahyar Mirmajlessi and Ramalingam Radhakrishnan",coverURL:"https://cdn.intechopen.com/books/images_new/8954.jpg",editedByType:"Edited by",editors:[{id:"100573",title:"Dr.",name:"Seyed Mahyar",middleName:null,surname:"Mirmajlessi",slug:"seyed-mahyar-mirmajlessi",fullName:"Seyed Mahyar Mirmajlessi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8004",title:"Nitrogen Fixation",subtitle:null,isOpenForSubmission:!1,hash:"02f39c8365ba155d1c520184c2f26976",slug:"nitrogen-fixation",bookSignature:"Everlon Cid Rigobelo and Ademar Pereira Serra",coverURL:"https://cdn.intechopen.com/books/images_new/8004.jpg",editedByType:"Edited by",editors:[{id:"39553",title:"Prof.",name:"Everlon",middleName:"Cid",surname:"Rigobelo",slug:"everlon-rigobelo",fullName:"Everlon Rigobelo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7206",title:"Corn",subtitle:"Production and Human Health in Changing Climate",isOpenForSubmission:!1,hash:"0140cb7a425a230a388fcece870e62b2",slug:"corn-production-and-human-health-in-changing-climate",bookSignature:"Amanullah and Shah Fahad",coverURL:"https://cdn.intechopen.com/books/images_new/7206.jpg",editedByType:"Edited by",editors:[{id:"178825",title:"Dr.",name:"Dr.",middleName:null,surname:"Amanullah",slug:"dr.-amanullah",fullName:"Dr. Amanullah"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1958",title:"Phytochemicals as Nutraceuticals",subtitle:"Global Approaches to Their Role in Nutrition and Health",isOpenForSubmission:!1,hash:"7a4d422838dabdc758119a7dfc6e7a54",slug:"phytochemicals-as-nutraceuticals-global-approaches-to-their-role-in-nutrition-and-health",bookSignature:"Venketeshwer Rao",coverURL:"https://cdn.intechopen.com/books/images_new/1958.jpg",editedByType:"Edited by",editors:[{id:"82663",title:"Dr.",name:"Venketeshwer",middleName:null,surname:"Rao",slug:"venketeshwer-rao",fullName:"Venketeshwer Rao"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],booksByTopicTotal:5,seriesByTopicCollection:[],seriesByTopicTotal:0,mostCitedChapters:[{id:"32901",doi:"10.5772/27843",title:"Plant Polyphenols as Antioxidants Influencing the Human Health",slug:"plant-polyphenols-as-antioxidants-influencing-the-human-health",totalDownloads:6827,totalCrossrefCites:16,totalDimensionsCites:35,abstract:null,book:{id:"1958",slug:"phytochemicals-as-nutraceuticals-global-approaches-to-their-role-in-nutrition-and-health",title:"Phytochemicals as Nutraceuticals",fullTitle:"Phytochemicals as Nutraceuticals - Global Approaches to Their Role in Nutrition and Health"},signatures:"Sanda Vladimir-Knežević, Biljana Blažeković, Maja Bival Štefan and Marija Babac",authors:[{id:"71793",title:"Dr.",name:"Biljana",middleName:null,surname:"Blazekovic",slug:"biljana-blazekovic",fullName:"Biljana Blazekovic"},{id:"76049",title:"Prof.",name:"Sanda",middleName:null,surname:"Vladimir-Knežević",slug:"sanda-vladimir-knezevic",fullName:"Sanda Vladimir-Knežević"},{id:"76050",title:"MSc.",name:"Maja",middleName:null,surname:"Bival Štefan",slug:"maja-bival-stefan",fullName:"Maja Bival Štefan"},{id:"76054",title:"MSc.",name:"Marija",middleName:null,surname:"Babac",slug:"marija-babac",fullName:"Marija Babac"}]},{id:"32893",doi:"10.5772/26956",title:"Biological Oxidations and Antioxidant Activity of Natural Products",slug:"biological-oxidations-and-antioxidant-activity-of-natural-products",totalDownloads:6200,totalCrossrefCites:7,totalDimensionsCites:33,abstract:null,book:{id:"1958",slug:"phytochemicals-as-nutraceuticals-global-approaches-to-their-role-in-nutrition-and-health",title:"Phytochemicals as Nutraceuticals",fullTitle:"Phytochemicals as Nutraceuticals - Global Approaches to Their Role in Nutrition and Health"},signatures:"Xirley Pereira Nunes, Fabrício Souza Silva, Jackson Roberto Guedes da S. Almeida, Julianeli Tolentino de Lima, Luciano Augusto de Araújo Ribeiro, Lucindo José Quintans Júnior and José Maria Barbosa Filho",authors:[{id:"68388",title:"Dr.",name:"Xirley",middleName:null,surname:"Nunes",slug:"xirley-nunes",fullName:"Xirley Nunes"},{id:"70159",title:"Dr.",name:"Lucindo",middleName:null,surname:"Quintans-Júnior",slug:"lucindo-quintans-junior",fullName:"Lucindo Quintans-Júnior"},{id:"72113",title:"Prof.",name:"Jackson",middleName:"Roberto Guedes Da Silva",surname:"Almeida",slug:"jackson-almeida",fullName:"Jackson Almeida"},{id:"72114",title:"Dr.",name:"Julianeli",middleName:"Tolentino",surname:"Lima",slug:"julianeli-lima",fullName:"Julianeli Lima"},{id:"73341",title:"Prof.",name:"José Maria",middleName:null,surname:"Barbosa-Filho",slug:"jose-maria-barbosa-filho",fullName:"José Maria Barbosa-Filho"},{id:"76185",title:"Dr.",name:"Luciano",middleName:null,surname:"Ribeiro",slug:"luciano-ribeiro",fullName:"Luciano Ribeiro"},{id:"76187",title:"MSc.",name:"Fabrício",middleName:null,surname:"Silva",slug:"fabricio-silva",fullName:"Fabrício Silva"}]},{id:"32903",doi:"10.5772/30459",title:"Potato Peel as a Source of Important Phytochemical Antioxidant Nutraceuticals and Their Role in Human Health - A Review",slug:"potato-peel-as-a-source-of-important-phytochemical-antioxidant-nutraceuticals-and-their-role-in-huma",totalDownloads:8546,totalCrossrefCites:12,totalDimensionsCites:28,abstract:null,book:{id:"1958",slug:"phytochemicals-as-nutraceuticals-global-approaches-to-their-role-in-nutrition-and-health",title:"Phytochemicals as Nutraceuticals",fullTitle:"Phytochemicals as Nutraceuticals - Global Approaches to Their Role in Nutrition and Health"},signatures:"A. Al-Weshahy and V.A. Rao",authors:[{id:"82663",title:"Dr.",name:"Venketeshwer",middleName:null,surname:"Rao",slug:"venketeshwer-rao",fullName:"Venketeshwer Rao"},{id:"150485",title:"Dr.",name:"Amir",middleName:null,surname:"Al-Weshahy",slug:"amir-al-weshahy",fullName:"Amir Al-Weshahy"}]},{id:"69956",doi:"10.5772/intechopen.88829",title:"Biostimulants and Their Role in Improving Plant Growth under Abiotic Stresses",slug:"biostimulants-and-their-role-in-improving-plant-growth-under-abiotic-stresses",totalDownloads:2637,totalCrossrefCites:9,totalDimensionsCites:25,abstract:"Biostimulants are products that reduce the need for fertilizers and increase plant growth, resistance to water and abiotic stresses. In small concentrations, these substances are efficient, favoring the good performance of the plant’s vital processes, and allowing high yields and good quality products. In addition, biostimulants applied to plants enhance nutrition efficiency, abiotic stress tolerance and/or plant quality traits, regardless of its nutrient contents. Several researches have been developed in order to evaluate the biostimulants in improving plant development subjected to stresses, saline environment, and development of seedlings, among others. Furthermore, various raw materials have been used in biostimulant compositions, such as humic acids, hormones, algae extracts, and plant growth-promoting bacteria. In this sense, this chapter aims to approach the use of biostimulants in plant growth according to the raw material used in their compositions as well as their effects on plants subjected to abiotic stresses.",book:{id:"8954",slug:"biostimulants-in-plant-science",title:"Biostimulants in Plant Science",fullTitle:"Biostimulants in Plant Science"},signatures:"Ana Carolina Feitosa de Vasconcelos and Lúcia Helena Garófalo Chaves",authors:null},{id:"32894",doi:"10.5772/27308",title:"Antimicrobial and Antioxidant Activities of Some Plant Extracts",slug:"antimicrobial-and-antioxidant-activities-of-some-plant-extracts",totalDownloads:7076,totalCrossrefCites:7,totalDimensionsCites:20,abstract:null,book:{id:"1958",slug:"phytochemicals-as-nutraceuticals-global-approaches-to-their-role-in-nutrition-and-health",title:"Phytochemicals as Nutraceuticals",fullTitle:"Phytochemicals as Nutraceuticals - Global Approaches to Their Role in Nutrition and Health"},signatures:"Elita Scio, Renata F. Mendes, Erick V.S. Motta, Paula M.Q. Bellozi, Danielle M.O. Aragão, Josiane Mello, Rodrigo L. Fabri, Jussara R. Moreira, Isabel V.L. de Assis and Maria Lúcia M. Bouzada",authors:[{id:"69660",title:"Dr.",name:"Elita",middleName:null,surname:"Scio",slug:"elita-scio",fullName:"Elita Scio"},{id:"76248",title:"MSc.",name:"Rodrigo",middleName:null,surname:"Fabri",slug:"rodrigo-fabri",fullName:"Rodrigo Fabri"},{id:"76251",title:"MSc.",name:"Danielle",middleName:null,surname:"Aragão",slug:"danielle-aragao",fullName:"Danielle Aragão"},{id:"76253",title:"Ms.",name:"Renata",middleName:null,surname:"Mendes",slug:"renata-mendes",fullName:"Renata Mendes"},{id:"76256",title:"Mr.",name:"Erick",middleName:null,surname:"Motta",slug:"erick-motta",fullName:"Erick Motta"},{id:"76259",title:"Ms.",name:"Isabel",middleName:null,surname:"Assis",slug:"isabel-assis",fullName:"Isabel Assis"},{id:"76261",title:"Ms.",name:"Jussara",middleName:null,surname:"Moreira",slug:"jussara-moreira",fullName:"Jussara Moreira"},{id:"76262",title:"MSc.",name:"Maria Lucia",middleName:null,surname:"Bouzada",slug:"maria-lucia-bouzada",fullName:"Maria Lucia Bouzada"},{id:"76264",title:"Ms.",name:"Paula",middleName:null,surname:"Bellozi",slug:"paula-bellozi",fullName:"Paula Bellozi"},{id:"76266",title:"MSc.",name:"Josiane",middleName:null,surname:"Mello",slug:"josiane-mello",fullName:"Josiane Mello"}]}],mostDownloadedChaptersLast30Days:[{id:"69956",title:"Biostimulants and Their Role in Improving Plant Growth under Abiotic Stresses",slug:"biostimulants-and-their-role-in-improving-plant-growth-under-abiotic-stresses",totalDownloads:2651,totalCrossrefCites:9,totalDimensionsCites:25,abstract:"Biostimulants are products that reduce the need for fertilizers and increase plant growth, resistance to water and abiotic stresses. In small concentrations, these substances are efficient, favoring the good performance of the plant’s vital processes, and allowing high yields and good quality products. In addition, biostimulants applied to plants enhance nutrition efficiency, abiotic stress tolerance and/or plant quality traits, regardless of its nutrient contents. Several researches have been developed in order to evaluate the biostimulants in improving plant development subjected to stresses, saline environment, and development of seedlings, among others. Furthermore, various raw materials have been used in biostimulant compositions, such as humic acids, hormones, algae extracts, and plant growth-promoting bacteria. In this sense, this chapter aims to approach the use of biostimulants in plant growth according to the raw material used in their compositions as well as their effects on plants subjected to abiotic stresses.",book:{id:"8954",slug:"biostimulants-in-plant-science",title:"Biostimulants in Plant Science",fullTitle:"Biostimulants in Plant Science"},signatures:"Ana Carolina Feitosa de Vasconcelos and Lúcia Helena Garófalo Chaves",authors:null},{id:"69577",title:"Role of Fungi in Agriculture",slug:"role-of-fungi-in-agriculture",totalDownloads:1635,totalCrossrefCites:5,totalDimensionsCites:6,abstract:"Fungi are a group of eukaryotic organisms and source of food, organic acids, alcohol, antibiotics, growth-promoting substances, enzymes, and amino acids. They include microorganisms like molds, yeasts, and mushrooms. They live on dead or living plants or animals’ tissue. Fungi are very different from other living organisms; they are the primary decomposers of substances in the ecological system. Fungi are tremendous decomposer of organic waste material and most readily attack cellulose, lignins, gums, and other organic complex substances. Fungi can act also under a wide range of soil reaction from acidic to alkaline soil reactions. Fungi conjointly play a basic role in different physiological processes as well as mineral and water uptake, chemical change, stomatal movement, and biosynthesis of compounds termed biostimulants, auxins, lignan, and ethylene to enhance the flexibility of plants to ascertain and cope environmental stresses like drought, salinity, heat, cold, and significant metals.",book:{id:"8954",slug:"biostimulants-in-plant-science",title:"Biostimulants in Plant Science",fullTitle:"Biostimulants in Plant Science"},signatures:"Muthuraman Yuvaraj and Murugaragavan Ramasamy",authors:[{id:"280193",title:"Dr.",name:"Muthuraman",middleName:null,surname:"Yuvaraj",slug:"muthuraman-yuvaraj",fullName:"Muthuraman Yuvaraj"},{id:"289410",title:"Dr.",name:"Murugaragavan",middleName:null,surname:"Ramasamy",slug:"murugaragavan-ramasamy",fullName:"Murugaragavan Ramasamy"}]},{id:"62653",title:"Phytochemical Composition: Antioxidant Potential and Biological Activities of Corn",slug:"phytochemical-composition-antioxidant-potential-and-biological-activities-of-corn",totalDownloads:2206,totalCrossrefCites:1,totalDimensionsCites:4,abstract:"Corn seeds are used as a nutritional source for humans, and the stem and leaves are utilized as fodder for cattle throughout the world. Corn silk and corn cob are usually discarded as waste. This chapter highlights the nutritional as well as medicinal importance of various parts of corn plant. All parts of corn plant are good source of a variety of bioactive phytochemical compounds which possess antioxidant potential. The principal phytochemicals present in corn seed and corn silk include polyphenols, phenolic acids, flavonoids, anthocyanins, glycosides, carotenoids, and polysaccharides of biological importance, reducing compounds and some water-soluble vitamins. The presence of these phytochemicals makes corn a medicinal plant which shows various biological activities particularly the antioxidant, antimicrobial, antidiabetic, anti-obesity, antiproliferative, hepatoprotective, cardioprotective, and renal-protective activities. On the account of its high antioxidant potential, all parts of corn plant can be used for the management of oxidative stress and the treatment of various diseases.",book:{id:"7206",slug:"corn-production-and-human-health-in-changing-climate",title:"Corn",fullTitle:"Corn - Production and Human Health in Changing Climate"},signatures:"Haq Nawaz, Saima Muzaffar, Momna Aslam and Shakeel Ahmad",authors:[{id:"230900",title:"Mr.",name:"Haq",middleName:null,surname:"Nawaz",slug:"haq-nawaz",fullName:"Haq Nawaz"},{id:"244066",title:"Prof.",name:"Saima",middleName:null,surname:"Muzaffar",slug:"saima-muzaffar",fullName:"Saima Muzaffar"},{id:"263041",title:"Ms.",name:"Momna",middleName:null,surname:"Aslam",slug:"momna-aslam",fullName:"Momna Aslam"},{id:"263042",title:"Dr.",name:"Shakeel",middleName:null,surname:"Ahmad",slug:"shakeel-ahmad",fullName:"Shakeel Ahmad"}]},{id:"70950",title:"Role of Biofertilizers in Plant Growth and Soil Health",slug:"role-of-biofertilizers-in-plant-growth-and-soil-health",totalDownloads:1434,totalCrossrefCites:4,totalDimensionsCites:11,abstract:"Biofertilizers nowadays have been realised for shifting fortunes in agriculture. It has been proven successful technology in many developed countries while in developing countries exploitation of bioinoculants is hampered by several factors. Scientific knowledge on bioinoculants and its usage will pave way for its effective usage. At the same time overlooking the significance of ensuring and maintaining a high quality standard of the product will have negative impact. Hence a proper knowledge of bioinoculants and its functioning will pave way to tape the resources in a better way. Thus the chapter provide overview knowledge about different bacterial, fungal and algal biofertilizers, its associations with plants and transformations of nutrients in soil. Adopting a rational approach to the use and management of microbial fertilizers in sustainable agriculture thrive vast potential for the future.",book:{id:"8004",slug:"nitrogen-fixation",title:"Nitrogen Fixation",fullTitle:"Nitrogen Fixation"},signatures:"Murugaragavan Ramasamy, T. Geetha and M. Yuvaraj",authors:[{id:"289410",title:"Dr.",name:"Murugaragavan",middleName:null,surname:"Ramasamy",slug:"murugaragavan-ramasamy",fullName:"Murugaragavan Ramasamy"}]},{id:"67454",title:"Nitrogen Fertilization I: Impact on Crop, Soil, and Environment",slug:"nitrogen-fertilization-i-impact-on-crop-soil-and-environment",totalDownloads:1613,totalCrossrefCites:7,totalDimensionsCites:17,abstract:"Nitrogen (N) is a major limiting nutrient to sustain crop yields and quality. As a result, N fertilizer is usually applied in large quantity to increase crop production throughout the world. Application of N fertilizers has increased crop yields and resulted in achievement of self-sufficiency in food production in many developing countries. Excessive application of N fertilizers beyond crops’ demand, however, has resulted in undesirable consequences of degradation in soil, water, and air quality. These include soil acidification, N leaching in groundwater, and emissions of nitrous oxide (N2O), a potent greenhouse gas that contributes to global warming. Long-term application of ammonia-based N fertilizers, such as urea, has increased soil acidity which rendered to soil infertility where crops fail to respond with further application of N fertilizers. Another problem is the groundwater contamination of nitrate-N (NO3-N) which can be a health hazard to human and livestock if its concentration goes above 10 mg L−1 in drinking water. The third problem is emissions of N2O gas which is 300 times more powerful than carbon dioxide in terms of global warming potential. This chapter examines the effect of N fertilization on soil and environmental quality and crop yields.",book:{id:"8004",slug:"nitrogen-fixation",title:"Nitrogen Fixation",fullTitle:"Nitrogen Fixation"},signatures:"Upendra M. Sainju, Rajan Ghimire and Gautam P. Pradhan",authors:[{id:"214367",title:"Dr.",name:"Upendra",middleName:null,surname:"Sainju",slug:"upendra-sainju",fullName:"Upendra Sainju"},{id:"266570",title:"Prof.",name:"Rajan",middleName:null,surname:"Ghimire",slug:"rajan-ghimire",fullName:"Rajan Ghimire"},{id:"266571",title:"Prof.",name:"Gautam",middleName:null,surname:"Pradhan",slug:"gautam-pradhan",fullName:"Gautam Pradhan"}]}],onlineFirstChaptersFilter:{topicId:"349",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:139,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:122,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:21,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:10,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"10",title:"Physiology",doi:"10.5772/intechopen.72796",issn:"2631-8261",scope:"Modern physiology requires a comprehensive understanding of the integration of tissues and organs throughout the mammalian body, including the cooperation between structure and function at the cellular and molecular levels governed by gene and protein expression. While a daunting task, learning is facilitated by identifying common and effective signaling pathways mediated by a variety of factors employed by nature to preserve and sustain homeostatic life. \r\nAs a leading example, the cellular interaction between intracellular concentration of Ca+2 increases, and changes in plasma membrane potential is integral for coordinating blood flow, governing the exocytosis of neurotransmitters, and modulating gene expression and cell effector secretory functions. Furthermore, in this manner, understanding the systemic interaction between the cardiovascular and nervous systems has become more important than ever as human populations' life prolongation, aging and mechanisms of cellular oxidative signaling are utilised for sustaining life. \r\nAltogether, physiological research enables our identification of distinct and precise points of transition from health to the development of multimorbidity throughout the inevitable aging disorders (e.g., diabetes, hypertension, chronic kidney disease, heart failure, peptic ulcer, inflammatory bowel disease, age-related macular degeneration, cancer). With consideration of all organ systems (e.g., brain, heart, lung, gut, skeletal and smooth muscle, liver, pancreas, kidney, eye) and the interactions thereof, this Physiology Series will address the goals of resolving (1) Aging physiology and chronic disease progression (2) Examination of key cellular pathways as they relate to calcium, oxidative stress, and electrical signaling, and (3) how changes in plasma membrane produced by lipid peroxidation products can affect aging physiology, covering new research in the area of cell, human, plant and animal physiology.",coverUrl:"https://cdn.intechopen.com/series/covers/10.jpg",latestPublicationDate:"July 20th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:14,editor:{id:"35854",title:"Prof.",name:"Tomasz",middleName:null,surname:"Brzozowski",slug:"tomasz-brzozowski",fullName:"Tomasz Brzozowski",profilePictureURL:"https://mts.intechopen.com/storage/users/35854/images/system/35854.jpg",biography:"Prof. Dr. Thomas Brzozowski works as a professor of Human Physiology and is currently Chairman at the Department of Physiology and is V-Dean of the Medical Faculty at Jagiellonian University Medical College, Cracow, Poland. His primary area of interest is physiology and pathophysiology of the gastrointestinal (GI) tract, with the major focus on the mechanism of GI mucosal defense, protection, and ulcer healing. He was a postdoctoral NIH fellow at the University of California and the Gastroenterology VA Medical Center, Irvine, Long Beach, CA, USA, and at the Gastroenterology Clinics Erlangen-Nuremberg and Munster in Germany. He has published 290 original articles in some of the most prestigious scientific journals and seven book chapters on the pathophysiology of the GI tract, gastroprotection, ulcer healing, drug therapy of peptic ulcers, hormonal regulation of the gut, and inflammatory bowel disease.",institutionString:null,institution:{name:"Jagiellonian University",institutionURL:null,country:{name:"Poland"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:6,paginationItems:[{id:"10",title:"Animal Physiology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/10.jpg",editor:{id:"202192",title:"Dr.",name:"Catrin",middleName:null,surname:"Rutland",slug:"catrin-rutland",fullName:"Catrin Rutland",profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",biography:"Catrin Rutland is an Associate Professor of Anatomy and Developmental Genetics at the University of Nottingham, UK. She obtained a BSc from the University of Derby, England, a master’s degree from Technische Universität München, Germany, and a Ph.D. from the University of Nottingham. She undertook a post-doctoral research fellowship in the School of Medicine before accepting tenure in Veterinary Medicine and Science. Dr. Rutland also obtained an MMedSci (Medical Education) and a Postgraduate Certificate in Higher Education (PGCHE). She is the author of more than sixty peer-reviewed journal articles, twelve books/book chapters, and more than 100 research abstracts in cardiovascular biology and oncology. She is a board member of the European Association of Veterinary Anatomists, Fellow of the Anatomical Society, and Senior Fellow of the Higher Education Academy. Dr. Rutland has also written popular science books for the public. https://orcid.org/0000-0002-2009-4898. www.nottingham.ac.uk/vet/people/catrin.rutland",institutionString:null,institution:{name:"University of Nottingham",institutionURL:null,country:{name:"United Kingdom"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"306970",title:"Mr.",name:"Amin",middleName:null,surname:"Tamadon",slug:"amin-tamadon",fullName:"Amin Tamadon",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002oHR5wQAG/Profile_Picture_1623910304139",institutionString:null,institution:{name:"Bushehr University of Medical Sciences",institutionURL:null,country:{name:"Iran"}}},{id:"251314",title:"Dr.",name:"Juan Carlos",middleName:null,surname:"Gardón Poggi",slug:"juan-carlos-gardon-poggi",fullName:"Juan Carlos Gardón Poggi",profilePictureURL:"https://mts.intechopen.com/storage/users/251314/images/system/251314.jpeg",institutionString:null,institution:{name:"Valencia Catholic University Saint Vincent Martyr",institutionURL:null,country:{name:"Spain"}}},{id:"245306",title:"Dr.",name:"María Luz",middleName:null,surname:"Garcia Pardo",slug:"maria-luz-garcia-pardo",fullName:"María Luz Garcia Pardo",profilePictureURL:"https://mts.intechopen.com/storage/users/245306/images/system/245306.png",institutionString:null,institution:{name:"Miguel Hernandez University",institutionURL:null,country:{name:"Spain"}}},{id:"283315",title:"Prof.",name:"Samir",middleName:null,surname:"El-Gendy",slug:"samir-el-gendy",fullName:"Samir El-Gendy",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRduYQAS/Profile_Picture_1606215849748",institutionString:null,institution:{name:"Alexandria University",institutionURL:null,country:{name:"Egypt"}}},{id:"178366",title:"Dr.",name:"Volkan",middleName:null,surname:"Gelen",slug:"volkan-gelen",fullName:"Volkan Gelen",profilePictureURL:"https://mts.intechopen.com/storage/users/178366/images/system/178366.jpg",institutionString:"Kafkas University",institution:{name:"Kafkas University",institutionURL:null,country:{name:"Turkey"}}}]},{id:"11",title:"Cell Physiology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/11.jpg",editor:{id:"133493",title:"Prof.",name:"Angel",middleName:null,surname:"Catala",slug:"angel-catala",fullName:"Angel Catala",profilePictureURL:"https://mts.intechopen.com/storage/users/133493/images/3091_n.jpg",biography:"Prof. Dr. Angel Catalá \r\nShort Biography Angel Catalá was born in Rodeo (San Juan, Argentina). He studied \r\nchemistry at the Universidad Nacional de La Plata, Argentina, where received aPh.D. degree in chemistry (Biological Branch) in 1965. From\r\n1964 to 1974, he worked as Assistant in Biochemistry at the School of MedicineUniversidad Nacional de La Plata, Argentina. From 1974 to 1976, he was a Fellowof the National Institutes of Health (NIH) at the University of Connecticut, Health Center, USA. From 1985 to 2004, he served as a Full Professor oBiochemistry at the Universidad Nacional de La Plata, Argentina. He is Member ofthe National Research Council (CONICET), Argentina, and Argentine Society foBiochemistry and Molecular Biology (SAIB). His laboratory has been interested for manyears in the lipid peroxidation of biological membranes from various tissues and different species. Professor Catalá has directed twelve doctoral theses, publishedover 100 papers in peer reviewed journals, several chapters in books andtwelve edited books. Angel Catalá received awards at the 40th InternationaConference Biochemistry of Lipids 1999: Dijon (France). W inner of the Bimbo PanAmerican Nutrition, Food Science and Technology Award 2006 and 2012, South AmericaHuman Nutrition, Professional Category. 2006 award in pharmacology, Bernardo\r\nHoussay, in recognition of his meritorious works of research. Angel Catalá belongto the Editorial Board of Journal of lipids, International Review of Biophysical ChemistryFrontiers in Membrane Physiology and Biophysics, World Journal oExperimental Medicine and Biochemistry Research International, W orld Journal oBiological Chemistry, Oxidative Medicine and Cellular Longevity, Diabetes and thePancreas, International Journal of Chronic Diseases & Therapy, International Journal oNutrition, Co-Editor of The Open Biology Journal.",institutionString:null,institution:{name:"National University of La Plata",institutionURL:null,country:{name:"Argentina"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"186048",title:"Prof.",name:"Ines",middleName:null,surname:"Drenjančević",slug:"ines-drenjancevic",fullName:"Ines Drenjančević",profilePictureURL:"https://mts.intechopen.com/storage/users/186048/images/5818_n.jpg",institutionString:null,institution:{name:"University of Osijek",institutionURL:null,country:{name:"Croatia"}}},{id:"187859",title:"Prof.",name:"Kusal",middleName:"K.",surname:"Das",slug:"kusal-das",fullName:"Kusal Das",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSBDeQAO/Profile_Picture_1623411145568",institutionString:"BLDE (Deemed to be University), India",institution:null},{id:"79615",title:"Dr.",name:"Robson",middleName:null,surname:"Faria",slug:"robson-faria",fullName:"Robson Faria",profilePictureURL:"https://mts.intechopen.com/storage/users/79615/images/system/79615.png",institutionString:null,institution:{name:"Oswaldo Cruz Foundation",institutionURL:null,country:{name:"Brazil"}}},{id:"84459",title:"Prof.",name:"Valerie",middleName:null,surname:"Chappe",slug:"valerie-chappe",fullName:"Valerie Chappe",profilePictureURL:"https://mts.intechopen.com/storage/users/84459/images/system/84459.jpg",institutionString:null,institution:{name:"Dalhousie University",institutionURL:null,country:{name:"Canada"}}}]},{id:"12",title:"Human Physiology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/12.jpg",editor:{id:"195829",title:"Prof.",name:"Kunihiro",middleName:null,surname:"Sakuma",slug:"kunihiro-sakuma",fullName:"Kunihiro Sakuma",profilePictureURL:"https://mts.intechopen.com/storage/users/195829/images/system/195829.jpg",biography:"Professor Kunihiro Sakuma, Ph.D., currently works in the Institute for Liberal Arts at the Tokyo Institute of Technology. He is a physiologist working in the field of skeletal muscle. He was awarded his sports science diploma in 1995 by the University of Tsukuba and began his scientific work at the Department of Physiology, Aichi Human Service Center, focusing on the molecular mechanism of congenital muscular dystrophy and normal muscle regeneration. His interest later turned to the molecular mechanism and attenuating strategy of sarcopenia (age-related muscle atrophy). His opinion is to attenuate sarcopenia by improving autophagic defects using nutrient- and pharmaceutical-based treatments.",institutionString:null,institution:{name:"Tokyo Institute of Technology",institutionURL:null,country:{name:"Japan"}}},editorTwo:{id:"331519",title:"Dr.",name:"Kotomi",middleName:null,surname:"Sakai",slug:"kotomi-sakai",fullName:"Kotomi Sakai",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000031QtFXQA0/Profile_Picture_1637053227318",biography:"Senior researcher Kotomi Sakai, Ph.D., MPH, works at the Research Organization of Science and Technology in Ritsumeikan University. She is a researcher in the geriatric rehabilitation and public health field. She received Ph.D. from Nihon University and MPH from St.Luke’s International University. Her main research interest is sarcopenia in older adults, especially its association with nutritional status. Additionally, to understand how to maintain and improve physical function in older adults, to conduct studies about the mechanism of sarcopenia and determine when possible interventions are needed.",institutionString:null,institution:{name:"Ritsumeikan University",institutionURL:null,country:{name:"Japan"}}},editorThree:null,editorialBoard:[{id:"213786",title:"Dr.",name:"Henrique P.",middleName:null,surname:"Neiva",slug:"henrique-p.-neiva",fullName:"Henrique P. Neiva",profilePictureURL:"https://mts.intechopen.com/storage/users/213786/images/system/213786.png",institutionString:null,institution:{name:"University of Beira Interior",institutionURL:null,country:{name:"Portugal"}}},{id:"39275",title:"Prof.",name:"Herbert Ryan",middleName:null,surname:"Marini",slug:"herbert-ryan-marini",fullName:"Herbert Ryan Marini",profilePictureURL:"https://mts.intechopen.com/storage/users/39275/images/9459_n.jpg",institutionString:null,institution:{name:"University of Messina",institutionURL:null,country:{name:"Italy"}}},{id:"319576",title:"Prof.",name:"Nikolay",middleName:null,surname:"Boyadjiev",slug:"nikolay-boyadjiev",fullName:"Nikolay Boyadjiev",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00002v4b3cQAA/Profile_Picture_2022-06-07T08:30:58.jpeg",institutionString:null,institution:{name:"Medical University Plovdiv",institutionURL:null,country:{name:"Bulgaria"}}},{id:"196218",title:"Dr.",name:"Pasquale",middleName:null,surname:"Cianci",slug:"pasquale-cianci",fullName:"Pasquale Cianci",profilePictureURL:"https://mts.intechopen.com/storage/users/196218/images/system/196218.png",institutionString:null,institution:{name:"University of Foggia",institutionURL:null,country:{name:"Italy"}}}]},{id:"13",title:"Plant Physiology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/13.jpg",editor:{id:"332229",title:"Prof.",name:"Jen-Tsung",middleName:null,surname:"Chen",slug:"jen-tsung-chen",fullName:"Jen-Tsung Chen",profilePictureURL:"https://mts.intechopen.com/storage/users/332229/images/system/332229.png",biography:"Dr. Jen-Tsung Chen is currently a professor at the National University of Kaohsiung, Taiwan. He teaches cell biology, genomics, proteomics, medicinal plant biotechnology, and plant tissue culture. Dr. Chen\\'s research interests include bioactive compounds, chromatography techniques, in vitro culture, medicinal plants, phytochemicals, and plant biotechnology. He has published more than ninety scientific papers and serves as an editorial board member for Plant Methods, Biomolecules, and International Journal of Molecular Sciences.",institutionString:"National University of Kaohsiung",institution:{name:"National University of Kaohsiung",institutionURL:null,country:{name:"Taiwan"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"313856",title:"Dr.",name:"Christophe",middleName:"F.E.",surname:"Hano",slug:"christophe-hano",fullName:"Christophe Hano",profilePictureURL:"https://mts.intechopen.com/storage/users/313856/images/system/313856.png",institutionString:"University of Orléans",institution:{name:"University of Orléans",institutionURL:null,country:{name:"France"}}},{id:"33993",title:"Dr.",name:"Jose Carlos",middleName:null,surname:"Jimenez-Lopez",slug:"jose-carlos-jimenez-lopez",fullName:"Jose Carlos Jimenez-Lopez",profilePictureURL:"https://mts.intechopen.com/storage/users/33993/images/system/33993.jpg",institutionString:"Spanish National Research Council",institution:{name:"Spanish National Research Council",institutionURL:null,country:{name:"Spain"}}},{id:"191770",title:"Dr.",name:"Mohamed A.",middleName:null,surname:"El-Esawi",slug:"mohamed-a.-el-esawi",fullName:"Mohamed A. El-Esawi",profilePictureURL:"https://mts.intechopen.com/storage/users/191770/images/system/191770.jpeg",institutionString:null,institution:{name:"Tanta University",institutionURL:null,country:{name:"Egypt"}}},{id:"247858",title:"Dr.",name:"Saddam",middleName:null,surname:"Hussain",slug:"saddam-hussain",fullName:"Saddam Hussain",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSF2aQAG/Profile_Picture_1625658281836",institutionString:null,institution:{name:"University of Agriculture Faisalabad",institutionURL:null,country:{name:"Pakistan"}}}]}]},overviewPageOFChapters:{paginationCount:10,paginationItems:[{id:"82465",title:"Agroforestry: An Approach for Sustainability and Climate Mitigation",doi:"10.5772/intechopen.105406",signatures:"Ricardo O. Russo",slug:"agroforestry-an-approach-for-sustainability-and-climate-mitigation",totalDownloads:2,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Vegetation Dynamics, Changing Ecosystems and Human Responsibility",coverURL:"https://cdn.intechopen.com/books/images_new/11663.jpg",subseries:{id:"40",title:"Ecosystems and Biodiversity"}}},{id:"82754",title:"Impact of Revegetation on Ecological Restoration of a Constructed Soil in a Coal Mining in Southern Brazil",doi:"10.5772/intechopen.105895",signatures:"Lizete Stumpf, Maria Bertaso De Garcia Fernandez, Pablo Miguel, Luiz Fernando Spinelli Pinto, Ryan Noremberg Schubert, Luís Carlos Iuñes de Oliveira Filho, Tania Hipolito Montiel, Lucas Da Silva Barbosa, Jeferson Diego Leidemer and Thábata Barbosa Duarte",slug:"impact-of-revegetation-on-ecological-restoration-of-a-constructed-soil-in-a-coal-mining-in-southern-",totalDownloads:3,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Vegetation Dynamics, Changing Ecosystems and Human Responsibility",coverURL:"https://cdn.intechopen.com/books/images_new/11663.jpg",subseries:{id:"40",title:"Ecosystems and Biodiversity"}}},{id:"82828",title:"Vegetation and Avifauna Distribution in the Serengeti National Park",doi:"10.5772/intechopen.106165",signatures:"Ally K. Nkwabi and Pius Y. Kavana",slug:"vegetation-and-avifauna-distribution-in-the-serengeti-national-park",totalDownloads:6,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Vegetation Dynamics, Changing Ecosystems and Human Responsibility",coverURL:"https://cdn.intechopen.com/books/images_new/11663.jpg",subseries:{id:"40",title:"Ecosystems and Biodiversity"}}},{id:"82808",title:"Climate Change and Anthropogenic Impacts on the Ecosystem of the Transgressive Mud Coastal Region of Bight of Benin, Nigeria",doi:"10.5772/intechopen.105760",signatures:"Patrick O. Ayeku",slug:"climate-change-and-anthropogenic-impacts-on-the-ecosystem-of-the-transgressive-mud-coastal-region-of",totalDownloads:8,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Vegetation Dynamics, Changing Ecosystems and Human Responsibility",coverURL:"https://cdn.intechopen.com/books/images_new/11663.jpg",subseries:{id:"40",title:"Ecosystems and Biodiversity"}}}]},overviewPagePublishedBooks:{paginationCount:1,paginationItems:[{type:"book",id:"10843",title:"Persistent Organic Pollutants (POPs)",subtitle:"Monitoring, Impact and Treatment",coverURL:"https://cdn.intechopen.com/books/images_new/10843.jpg",slug:"persistent-organic-pollutants-pops-monitoring-impact-and-treatment",publishedDate:"April 13th 2022",editedByType:"Edited by",bookSignature:"Mohamed Nageeb Rashed",hash:"f5b1589f0a990b6114fef2dadc735dd9",volumeInSeries:1,fullTitle:"Persistent Organic Pollutants (POPs) - Monitoring, Impact and Treatment",editors:[{id:"63465",title:"Prof.",name:"Mohamed Nageeb",middleName:null,surname:"Rashed",slug:"mohamed-nageeb-rashed",fullName:"Mohamed Nageeb Rashed",profilePictureURL:"https://mts.intechopen.com/storage/users/63465/images/system/63465.gif",biography:"Prof. Mohamed Nageeb Rashed is Professor of Analytical and Environmental Chemistry and former vice-dean for environmental affairs, Faculty of Science, Aswan University, Egypt. He received his Ph.D. in Environmental Analytical Chemistry from Assiut University, Egypt, in 1989. His research interest is in analytical and environmental chemistry with special emphasis on: (1) monitoring and assessing biological trace elements and toxic metals in human blood, urine, water, crops, vegetables, and medicinal plants; (2) relationships between environmental heavy metals and human diseases; (3) uses of biological indicators for monitoring water pollution; (4) environmental chemistry of lakes, rivers, and well water; (5) water and wastewater treatment by adsorption and photocatalysis techniques; (6) soil and water pollution monitoring, control, and treatment; and (7) advanced oxidation treatment. Prof. Rashed has supervised several MSc and Ph.D. theses in the field of analytical and environmental chemistry. He served as an examiner for several Ph.D. theses in analytical chemistry in India, Kazakhstan, and Botswana. He has published about ninety scientific papers in peer-reviewed international journals and several papers in national and international conferences. He participated as an invited speaker at thirty international conferences. Prof. Rashed is the editor-in-chief and an editorial board member for several international journals in the fields of chemistry and environment. He is a member of several national and international societies. He received the Egyptian State Award for Environmental Research in 2001 and the Aswan University Merit Award for Basic Science in 2020. Prof. Rashed was recognized in Stanford University’s list of the World’s Top 2% Scientists in 2020 and 2021.",institutionString:null,institution:{name:"Aswan University",institutionURL:null,country:{name:"Egypt"}}}]}]},openForSubmissionBooks:{paginationCount:2,paginationItems:[{id:"12086",title:"Cattle Diseases - Molecular and Biochemical Approach",coverURL:"https://cdn.intechopen.com/books/images_new/12086.jpg",hash:"afdbf57e32d996556a94528c06623cf3",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"July 5th 2022",isOpenForSubmission:!0,editors:[{id:"219081",title:"Dr.",name:"Abdulsamed",surname:"Kükürt",slug:"abdulsamed-kukurt",fullName:"Abdulsamed Kükürt"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11579",title:"Animal Welfare - New Insights",coverURL:"https://cdn.intechopen.com/books/images_new/11579.jpg",hash:"12e4f41264cbe99028655e5463fa941a",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"July 8th 2022",isOpenForSubmission:!0,editors:[{id:"51520",title:"Dr.",name:"Shao-Wen",surname:"Hung",slug:"shao-wen-hung",fullName:"Shao-Wen Hung"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},onlineFirstChapters:{paginationCount:19,paginationItems:[{id:"82804",title:"Psychiatric Problems in HIV Care",doi:"10.5772/intechopen.106077",signatures:"Seggane Musisi and Noeline Nakasujja",slug:"psychiatric-problems-in-hiv-care",totalDownloads:1,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Future Opportunities and Tools for Emerging Challenges for HIV/AIDS Control",coverURL:"https://cdn.intechopen.com/books/images_new/11575.jpg",subseries:{id:"6",title:"Viral Infectious Diseases"}}},{id:"82827",title:"Epidemiology and Control of Schistosomiasis",doi:"10.5772/intechopen.105170",signatures:"Célestin Kyambikwa Bisangamo",slug:"epidemiology-and-control-of-schistosomiasis",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"New Horizons for Schistosomiasis Research",coverURL:"https://cdn.intechopen.com/books/images_new/10829.jpg",subseries:{id:"5",title:"Parasitic Infectious Diseases"}}},{id:"82817",title:"Perspective Chapter: Microfluidic Technologies for On-Site Detection and Quantification of Infectious Diseases - The Experience with SARS-CoV-2/COVID-19",doi:"10.5772/intechopen.105950",signatures:"Andres Escobar and Chang-qing Xu",slug:"perspective-chapter-microfluidic-technologies-for-on-site-detection-and-quantification-of-infectious",totalDownloads:3,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"SARS-CoV-2 Variants - Two Years After",coverURL:"https://cdn.intechopen.com/books/images_new/11573.jpg",subseries:{id:"6",title:"Viral Infectious Diseases"}}},{id:"82667",title:"Perspective Chapter: Analysis of SARS-CoV-2 Indirect Spreading Routes and Possible Countermeasures",doi:"10.5772/intechopen.105914",signatures:"Cesare Saccani, Marco Pellegrini and Alessandro Guzzini",slug:"perspective-chapter-analysis-of-sars-cov-2-indirect-spreading-routes-and-possible-countermeasures",totalDownloads:8,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"SARS-CoV-2 Variants - Two Years After",coverURL:"https://cdn.intechopen.com/books/images_new/11573.jpg",subseries:{id:"6",title:"Viral Infectious Diseases"}}},{id:"82559",title:"Perspective Chapter: Bioinformatics Study of the Evolution of SARS-CoV-2 Spike Protein",doi:"10.5772/intechopen.105915",signatures:"Črtomir Podlipnik, Radostina Alexandrova, Sebastian Pleško, Urban Bren and Marko Jukič",slug:"perspective-chapter-bioinformatics-study-of-the-evolution-of-sars-cov-2-spike-protein",totalDownloads:14,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"SARS-CoV-2 Variants - Two Years After",coverURL:"https://cdn.intechopen.com/books/images_new/11573.jpg",subseries:{id:"6",title:"Viral Infectious Diseases"}}},{id:"82521",title:"Challenges in Platelet Functions in HIV/AIDS Management",doi:"10.5772/intechopen.105731",signatures:"Gordon Ogweno",slug:"challenges-in-platelet-functions-in-hiv-aids-management",totalDownloads:16,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Future Opportunities and Tools for Emerging Challenges for HIV/AIDS Control",coverURL:"https://cdn.intechopen.com/books/images_new/11575.jpg",subseries:{id:"6",title:"Viral Infectious Diseases"}}},{id:"82701",title:"Pathology of Streptococcal Infections",doi:"10.5772/intechopen.105814",signatures:"Yutaka Tsutsumi",slug:"pathology-of-streptococcal-infections",totalDownloads:8,totalCrossrefCites:0,totalDimensionsCites:0,authors:[{name:"Yutaka",surname:"Tsutsumi"}],book:{title:"Streptococcal Infections",coverURL:"https://cdn.intechopen.com/books/images_new/10828.jpg",subseries:{id:"3",title:"Bacterial Infectious Diseases"}}},{id:"82634",title:"Bacterial Sexually Transmitted Disease",doi:"10.5772/intechopen.105747",signatures:"Lebeza Alemu Tenaw",slug:"bacterial-sexually-transmitted-disease",totalDownloads:12,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Bacterial Sexually Transmitted Infections - New Findings, Diagnosis, Treatment, and Prevention",coverURL:"https://cdn.intechopen.com/books/images_new/11569.jpg",subseries:{id:"3",title:"Bacterial Infectious Diseases"}}},{id:"82552",title:"Perspective Chapter: SARS-CoV-2 Variants - Two Years Post-Onset of the Pandemic",doi:"10.5772/intechopen.105913",signatures:"Adekunle Sanyaolu, Aleksandra Marinkovic, Stephanie Prakash, Chuku Okorie, Abdul Jan, Priyank Desai, Abu Fahad Abbasi, Jasmine Mangat, Zaheeda Hosein, Kareem Hamdy, Nafees Haider, Nasar Khan, Rochelle Annan, Olanrewaju Badaru, Ricardo Izurieta and Stella Smith",slug:"perspective-chapter-sars-cov-2-variants-two-years-post-onset-of-the-pandemic",totalDownloads:13,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"SARS-CoV-2 Variants - Two Years After",coverURL:"https://cdn.intechopen.com/books/images_new/11573.jpg",subseries:{id:"6",title:"Viral Infectious Diseases"}}},{id:"82380",title:"Evolution of Parasitism and Pathogenic Adaptations in Certain Medically Important Fungi",doi:"10.5772/intechopen.105206",signatures:"Gokul Shankar Sabesan, Ranjit Singh AJA, Ranjith Mehenderkar and Basanta Kumar Mohanty",slug:"evolution-of-parasitism-and-pathogenic-adaptations-in-certain-medically-important-fungi",totalDownloads:7,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Fungal Infectious Diseases - Annual Volume 2022",coverURL:"https://cdn.intechopen.com/books/images_new/11400.jpg",subseries:{id:"4",title:"Fungal Infectious Diseases"}}}]},subseriesFiltersForOFChapters:[{caption:"Fungal Infectious Diseases",value:4,count:1,group:"subseries"},{caption:"Parasitic Infectious Diseases",value:5,count:3,group:"subseries"},{caption:"Bacterial Infectious Diseases",value:3,count:5,group:"subseries"},{caption:"Viral Infectious Diseases",value:6,count:10,group:"subseries"}],publishedBooks:{paginationCount:9,paginationItems:[{type:"book",id:"10654",title:"Brain-Computer Interface",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/10654.jpg",slug:"brain-computer-interface",publishedDate:"May 18th 2022",editedByType:"Edited by",bookSignature:"Vahid Asadpour",hash:"a5308884068cc53ed31c6baba756857f",volumeInSeries:9,fullTitle:"Brain-Computer Interface",editors:[{id:"165328",title:"Dr.",name:"Vahid",middleName:null,surname:"Asadpour",slug:"vahid-asadpour",fullName:"Vahid Asadpour",profilePictureURL:"https://mts.intechopen.com/storage/users/165328/images/system/165328.jpg",institutionString:"Kaiser Permanente Southern California",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"10859",title:"Data Mining",subtitle:"Concepts and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10859.jpg",slug:"data-mining-concepts-and-applications",publishedDate:"March 30th 2022",editedByType:"Edited by",bookSignature:"Ciza Thomas",hash:"63a4e514e537d3962cf53ef1c6b9d5eb",volumeInSeries:8,fullTitle:"Data Mining - Concepts and Applications",editors:[{id:"43680",title:"Prof.",name:"Ciza",middleName:null,surname:"Thomas",slug:"ciza-thomas",fullName:"Ciza Thomas",profilePictureURL:"https://mts.intechopen.com/storage/users/43680/images/system/43680.jpeg",institutionString:null,institution:{name:"Government of Kerala",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"10651",title:"Machine Learning",subtitle:"Algorithms, Models and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10651.jpg",slug:"machine-learning-algorithms-models-and-applications",publishedDate:"December 22nd 2021",editedByType:"Edited by",bookSignature:"Jaydip Sen",hash:"6208156401c496e0a4ca5ff4265324cc",volumeInSeries:7,fullTitle:"Machine Learning - Algorithms, Models and Applications",editors:[{id:"4519",title:"Prof.",name:"Jaydip",middleName:null,surname:"Sen",slug:"jaydip-sen",fullName:"Jaydip Sen",profilePictureURL:"https://mts.intechopen.com/storage/users/4519/images/system/4519.jpeg",institutionString:"Praxis Business School",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9869",title:"Self-Driving Vehicles and Enabling Technologies",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9869.jpg",slug:"self-driving-vehicles-and-enabling-technologies",publishedDate:"September 22nd 2021",editedByType:"Edited by",bookSignature:"Marian Găiceanu",hash:"fd451ca2e4785ef098e04b7d695a18d9",volumeInSeries:6,fullTitle:"Self-Driving Vehicles and Enabling Technologies",editors:[{id:"169608",title:"Prof.",name:"Marian",middleName:null,surname:"Găiceanu",slug:"marian-gaiceanu",fullName:"Marian Găiceanu",profilePictureURL:"https://mts.intechopen.com/storage/users/169608/images/system/169608.png",institutionString:'"Dunarea de Jos" University of Galati',institution:{name:'"Dunarea de Jos" University of Galati',institutionURL:null,country:{name:"Romania"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9958",title:"Artificial Intelligence",subtitle:"Latest Advances, New Paradigms and Novel Applications",coverURL:"https://cdn.intechopen.com/books/images_new/9958.jpg",slug:"artificial-intelligence-latest-advances-new-paradigms-and-novel-applications",publishedDate:"September 1st 2021",editedByType:"Edited by",bookSignature:"Eneko Osaba, Esther Villar, Jesús L. Lobo and Ibai Laña",hash:"39648fbfdaa11385097d62b1f13aad54",volumeInSeries:5,fullTitle:"Artificial Intelligence - Latest Advances, New Paradigms and Novel Applications",editors:[{id:"221364",title:"Dr.",name:"Eneko",middleName:null,surname:"Osaba",slug:"eneko-osaba",fullName:"Eneko Osaba",profilePictureURL:"https://mts.intechopen.com/storage/users/221364/images/system/221364.jpg",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",institutionURL:null,country:{name:"Spain"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9963",title:"Advances and Applications in Deep Learning",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9963.jpg",slug:"advances-and-applications-in-deep-learning",publishedDate:"December 9th 2020",editedByType:"Edited by",bookSignature:"Marco Antonio Aceves-Fernandez",hash:"0d51ba46f22e55cb89140f60d86a071e",volumeInSeries:4,fullTitle:"Advances and Applications in Deep Learning",editors:[{id:"24555",title:"Dr.",name:"Marco Antonio",middleName:null,surname:"Aceves Fernandez",slug:"marco-antonio-aceves-fernandez",fullName:"Marco Antonio Aceves Fernandez",profilePictureURL:"https://mts.intechopen.com/storage/users/24555/images/system/24555.jpg",institutionString:"Universidad Autonoma de Queretaro",institution:{name:"Autonomous University of Queretaro",institutionURL:null,country:{name:"Mexico"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7656",title:"Fuzzy Logic",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7656.jpg",slug:"fuzzy-logic",publishedDate:"February 5th 2020",editedByType:"Edited by",bookSignature:"Constantin Volosencu",hash:"54f092d4ffe0abf5e4172a80025019bc",volumeInSeries:3,fullTitle:"Fuzzy Logic",editors:[{id:"1063",title:"Prof.",name:"Constantin",middleName:null,surname:"Volosencu",slug:"constantin-volosencu",fullName:"Constantin Volosencu",profilePictureURL:"https://mts.intechopen.com/storage/users/1063/images/system/1063.png",institutionString:'"Politechnica" University Timişoara',institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7726",title:"Swarm Intelligence",subtitle:"Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/7726.jpg",slug:"swarm-intelligence-recent-advances-new-perspectives-and-applications",publishedDate:"December 4th 2019",editedByType:"Edited by",bookSignature:"Javier Del Ser, Esther Villar and Eneko Osaba",hash:"e7ea7e74ce7a7a8e5359629e07c68d31",volumeInSeries:2,fullTitle:"Swarm Intelligence - Recent Advances, New Perspectives and Applications",editors:[{id:"49813",title:"Dr.",name:"Javier",middleName:null,surname:"Del Ser",slug:"javier-del-ser",fullName:"Javier Del Ser",profilePictureURL:"https://mts.intechopen.com/storage/users/49813/images/system/49813.png",institutionString:"Tecnalia Research & Innovation",institution:{name:"Tecnalia",institutionURL:null,country:{name:"Spain"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7723",title:"Artificial Intelligence",subtitle:"Applications in Medicine and Biology",coverURL:"https://cdn.intechopen.com/books/images_new/7723.jpg",slug:"artificial-intelligence-applications-in-medicine-and-biology",publishedDate:"July 31st 2019",editedByType:"Edited by",bookSignature:"Marco Antonio Aceves-Fernandez",hash:"a3852659e727f95c98c740ed98146011",volumeInSeries:1,fullTitle:"Artificial Intelligence - Applications in Medicine and Biology",editors:[{id:"24555",title:"Dr.",name:"Marco Antonio",middleName:null,surname:"Aceves Fernandez",slug:"marco-antonio-aceves-fernandez",fullName:"Marco Antonio Aceves Fernandez",profilePictureURL:"https://mts.intechopen.com/storage/users/24555/images/system/24555.jpg",institutionString:"Universidad Autonoma de Queretaro",institution:{name:"Autonomous University of Queretaro",institutionURL:null,country:{name:"Mexico"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Computational Neuroscience",value:23,count:1},{group:"subseries",caption:"Evolutionary Computation",value:25,count:1},{group:"subseries",caption:"Machine Learning and Data Mining",value:26,count:3},{group:"subseries",caption:"Applied Intelligence",value:22,count:4}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:2},{group:"publicationYear",caption:"2021",value:2021,count:3},{group:"publicationYear",caption:"2020",value:2020,count:2},{group:"publicationYear",caption:"2019",value:2019,count:2}],authors:{paginationCount:250,paginationItems:[{id:"274452",title:"Dr.",name:"Yousif",middleName:"Mohamed",surname:"Abdallah",slug:"yousif-abdallah",fullName:"Yousif Abdallah",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/274452/images/8324_n.jpg",biography:"I certainly enjoyed my experience in Radiotherapy and Nuclear Medicine, particularly it has been in different institutions and hospitals with different Medical Cultures and allocated resources. Radiotherapy and Nuclear Medicine Technology has always been my aspiration and my life. As years passed I accumulated a tremendous amount of skills and knowledge in Radiotherapy and Nuclear Medicine, Conventional Radiology, Radiation Protection, Bioinformatics Technology, PACS, Image processing, clinically and lecturing that will enable me to provide a valuable service to the community as a Researcher and Consultant in this field. My method of translating this into day to day in clinical practice is non-exhaustible and my habit of exchanging knowledge and expertise with others in those fields is the code and secret of success.",institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"313277",title:"Dr.",name:"Bartłomiej",middleName:null,surname:"Płaczek",slug:"bartlomiej-placzek",fullName:"Bartłomiej Płaczek",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/313277/images/system/313277.jpg",biography:"Bartłomiej Płaczek, MSc (2002), Ph.D. (2005), Habilitation (2016), is a professor at the University of Silesia, Institute of Computer Science, Poland, and an expert from the National Centre for Research and Development. His research interests include sensor networks, smart sensors, intelligent systems, and image processing with applications in healthcare and medicine. He is the author or co-author of more than seventy papers in peer-reviewed journals and conferences as well as the co-author of several books. He serves as a reviewer for many scientific journals, international conferences, and research foundations. Since 2010, Dr. Placzek has been a reviewer of grants and projects (including EU projects) in the field of information technologies.",institutionString:"University of Silesia",institution:{name:"University of Silesia",country:{name:"Poland"}}},{id:"35000",title:"Prof.",name:"Ulrich H.P",middleName:"H.P.",surname:"Fischer",slug:"ulrich-h.p-fischer",fullName:"Ulrich H.P Fischer",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/35000/images/3052_n.jpg",biography:"Academic and Professional Background\nUlrich H. P. has Diploma and PhD degrees in Physics from the Free University Berlin, Germany. He has been working on research positions in the Heinrich-Hertz-Institute in Germany. Several international research projects has been performed with European partners from France, Netherlands, Norway and the UK. He is currently Professor of Communications Systems at the Harz University of Applied Sciences, Germany.\n\nPublications and Publishing\nHe has edited one book, a special interest book about ‘Optoelectronic Packaging’ (VDE, Berlin, Germany), and has published over 100 papers and is owner of several international patents for WDM over POF key elements.\n\nKey Research and Consulting Interests\nUlrich’s research activity has always been related to Spectroscopy and Optical Communications Technology. Specific current interests include the validation of complex instruments, and the application of VR technology to the development and testing of measurement systems. He has been reviewer for several publications of the Optical Society of America\\'s including Photonics Technology Letters and Applied Optics.\n\nPersonal Interests\nThese include motor cycling in a very relaxed manner and performing martial arts.",institutionString:null,institution:{name:"Charité",country:{name:"Germany"}}},{id:"341622",title:"Ph.D.",name:"Eduardo",middleName:null,surname:"Rojas Alvarez",slug:"eduardo-rojas-alvarez",fullName:"Eduardo Rojas Alvarez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/341622/images/15892_n.jpg",biography:null,institutionString:null,institution:{name:"University of Cuenca",country:{name:"Ecuador"}}},{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/215610/images/system/215610.jpeg",biography:"Muhammad Sarfraz is a professor in the Department of Information Science, Kuwait University. His research interests include computer graphics, computer vision, image processing, machine learning, pattern recognition, soft computing, data science, intelligent systems, information technology, and information systems. Prof. Sarfraz has been a keynote/invited speaker on various platforms around the globe. He has advised various students for their MSc and Ph.D. theses. He has published more than 400 publications as books, journal articles, and conference papers. He is a member of various professional societies and a chair and member of the International Advisory Committees and Organizing Committees of various international conferences. Prof. Sarfraz is also an editor-in-chief and editor of various international journals.",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"32650",title:"Prof.",name:"Lukas",middleName:"Willem",surname:"Snyman",slug:"lukas-snyman",fullName:"Lukas Snyman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/32650/images/4136_n.jpg",biography:"Lukas Willem Snyman received his basic education at primary and high schools in South Africa, Eastern Cape. He enrolled at today's Nelson Metropolitan University and graduated from this university with a BSc in Physics and Mathematics, B.Sc Honors in Physics, MSc in Semiconductor Physics, and a Ph.D. in Semiconductor Physics in 1987. After his studies, he chose an academic career and devoted his energy to the teaching of physics to first, second, and third-year students. After positions as a lecturer at the University of Port Elizabeth, he accepted a position as Associate Professor at the University of Pretoria, South Africa.\r\n\r\nIn 1992, he motivates the concept of 'television and computer-based education” as means to reach large student numbers with only the best of teaching expertise and publishes an article on the concept in the SA Journal of Higher Education of 1993 (and later in 2003). The University of Pretoria subsequently approved a series of test projects on the concept with outreach to Mamelodi and Eerste Rust in 1993. In 1994, the University established a 'Unit for Telematic Education ' as a support section for multiple faculties at the University of Pretoria. In subsequent years, the concept of 'telematic education” subsequently becomes well established in academic circles in South Africa, grew in popularity, and is adopted by many universities and colleges throughout South Africa as a medium of enhancing education and training, as a method to reaching out to far out communities, and as a means to enhance study from the home environment.\r\n\r\nProfessor Snyman in subsequent years pursued research in semiconductor physics, semiconductor devices, microelectronics, and optoelectronics.\r\n\r\nIn 2000 he joined the TUT as a full professor. Here served for a period as head of the Department of Electronic Engineering. Here he makes contributions to solar energy development, microwave and optoelectronic device development, silicon photonics, as well as contributions to new mobile telecommunication systems and network planning in SA.\r\n\r\nCurrently, he teaches electronics and telecommunications at the TUT to audiences ranging from first-year students to Ph.D. level.\r\n\r\nFor his research in the field of 'Silicon Photonics” since 1990, he has published (as author and co-author) about thirty internationally reviewed articles in scientific journals, contributed to more than forty international conferences, about 25 South African provisional patents (as inventor and co-inventor), 8 PCT international patent applications until now. Of these, two USA patents applications, two European Patents, two Korean patents, and ten SA patents have been granted. A further 4 USA patents, 5 European patents, 3 Korean patents, 3 Chinese patents, and 3 Japanese patents are currently under consideration.\r\n\r\nRecently he has also published an extensive scholarly chapter in an internet open access book on 'Integrating Microphotonic Systems and MOEMS into standard Silicon CMOS Integrated circuitry”.\r\n\r\nFurthermore, Professor Snyman recently steered a new initiative at the TUT by introducing a 'Laboratory for Innovative Electronic Systems ' at the Department of Electrical Engineering. The model of this laboratory or center is to primarily combine outputs as achieved by high-level research with lower-level system development and entrepreneurship in a technical university environment. Students are allocated to projects at different levels with PhDs and Master students allocated to the generation of new knowledge and new technologies, while students at the diploma and Baccalaureus level are allocated to electronic systems development with a direct and a near application for application in industry or the commercial and public sectors in South Africa.\r\n\r\nProfessor Snyman received the WIRSAM Award of 1983 and the WIRSAM Award in 1985 in South Africa for best research papers by a young scientist at two international conferences on electron microscopy in South Africa. He subsequently received the SA Microelectronics Award for the best dissertation emanating from studies executed at a South African university in the field of Physics and Microelectronics in South Africa in 1987. In October of 2011, Professor Snyman received the prestigious Institutional Award for 'Innovator of the Year” for 2010 at the Tshwane University of Technology, South Africa. This award was based on the number of patents recognized and granted by local and international institutions as well as for his contributions concerning innovation at the TUT.",institutionString:null,institution:{name:"University of South Africa",country:{name:"South Africa"}}},{id:"317279",title:"Mr.",name:"Ali",middleName:"Usama",surname:"Syed",slug:"ali-syed",fullName:"Ali Syed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/317279/images/16024_n.png",biography:"A creative, talented, and innovative young professional who is dedicated, well organized, and capable research fellow with two years of experience in graduate-level research, published in engineering journals and book, with related expertise in Bio-robotics, equally passionate about the aesthetics of the mechanical and electronic system, obtained expertise in the use of MS Office, MATLAB, SolidWorks, LabVIEW, Proteus, Fusion 360, having a grasp on python, C++ and assembly language, possess proven ability in acquiring research grants, previous appointments with social and educational societies with experience in administration, current affiliations with IEEE and Web of Science, a confident presenter at conferences and teacher in classrooms, able to explain complex information to audiences of all levels.",institutionString:null,institution:{name:"Air University",country:{name:"Pakistan"}}},{id:"75526",title:"Ph.D.",name:"Zihni Onur",middleName:null,surname:"Uygun",slug:"zihni-onur-uygun",fullName:"Zihni Onur Uygun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/75526/images/12_n.jpg",biography:"My undergraduate education and my Master of Science educations at Ege University and at Çanakkale Onsekiz Mart University have given me a firm foundation in Biochemistry, Analytical Chemistry, Biosensors, Bioelectronics, Physical Chemistry and Medicine. After obtaining my degree as a MSc in analytical chemistry, I started working as a research assistant in Ege University Medical Faculty in 2014. In parallel, I enrolled to the MSc program at the Department of Medical Biochemistry at Ege University to gain deeper knowledge on medical and biochemical sciences as well as clinical chemistry in 2014. In my PhD I deeply researched on biosensors and bioelectronics and finished in 2020. Now I have eleven SCI-Expanded Index published papers, 6 international book chapters, referee assignments for different SCIE journals, one international patent pending, several international awards, projects and bursaries. In parallel to my research assistant position at Ege University Medical Faculty, Department of Medical Biochemistry, in April 2016, I also founded a Start-Up Company (Denosens Biotechnology LTD) by the support of The Scientific and Technological Research Council of Turkey. Currently, I am also working as a CEO in Denosens Biotechnology. The main purposes of the company, which carries out R&D as a research center, are to develop new generation biosensors and sensors for both point-of-care diagnostics; such as glucose, lactate, cholesterol and cancer biomarker detections. My specific experimental and instrumental skills are Biochemistry, Biosensor, Analytical Chemistry, Electrochemistry, Mobile phone based point-of-care diagnostic device, POCTs and Patient interface designs, HPLC, Tandem Mass Spectrometry, Spectrophotometry, ELISA.",institutionString:null,institution:{name:"Ege University",country:{name:"Turkey"}}},{id:"267434",title:"Dr.",name:"Rohit",middleName:null,surname:"Raja",slug:"rohit-raja",fullName:"Rohit Raja",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/267434/images/system/267434.jpg",biography:"Dr. Rohit Raja received Ph.D. in Computer Science and Engineering from Dr. CVRAMAN University in 2016. His main research interest includes Face recognition and Identification, Digital Image Processing, Signal Processing, and Networking. Presently he is working as Associate Professor in IT Department, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur (CG), India. He has authored several Journal and Conference Papers. He has good Academics & Research experience in various areas of CSE and IT. He has filed and successfully published 27 Patents. He has received many time invitations to be a Guest at IEEE Conferences. He has published 100 research papers in various International/National Journals (including IEEE, Springer, etc.) and Proceedings of the reputed International/ National Conferences (including Springer and IEEE). He has been nominated to the board of editors/reviewers of many peer-reviewed and refereed Journals (including IEEE, Springer).",institutionString:"Guru Ghasidas Vishwavidyalaya",institution:{name:"Guru Ghasidas Vishwavidyalaya",country:{name:"India"}}},{id:"246502",title:"Dr.",name:"Jaya T.",middleName:"T",surname:"Varkey",slug:"jaya-t.-varkey",fullName:"Jaya T. Varkey",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246502/images/11160_n.jpg",biography:"Jaya T. Varkey, PhD, graduated with a degree in Chemistry from Cochin University of Science and Technology, Kerala, India. She obtained a PhD in Chemistry from the School of Chemical Sciences, Mahatma Gandhi University, Kerala, India, and completed a post-doctoral fellowship at the University of Minnesota, USA. She is a research guide at Mahatma Gandhi University and Associate Professor in Chemistry, St. Teresa’s College, Kochi, Kerala, India.\nDr. Varkey received a National Young Scientist award from the Indian Science Congress (1995), a UGC Research award (2016–2018), an Indian National Science Academy (INSA) Visiting Scientist award (2018–2019), and a Best Innovative Faculty award from the All India Association for Christian Higher Education (AIACHE) (2019). She Hashas received the Sr. Mary Cecil prize for best research paper three times. She was also awarded a start-up to develop a tea bag water filter. \nDr. Varkey has published two international books and twenty-seven international journal publications. She is an editorial board member for five international journals.",institutionString:"St. Teresa’s College",institution:null},{id:"250668",title:"Dr.",name:"Ali",middleName:null,surname:"Nabipour Chakoli",slug:"ali-nabipour-chakoli",fullName:"Ali Nabipour Chakoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/250668/images/system/250668.jpg",biography:"Academic Qualification:\r\n•\tPhD in Materials Physics and Chemistry, From: Sep. 2006, to: Sep. 2010, School of Materials Science and Engineering, Harbin Institute of Technology, Thesis: Structure and Shape Memory Effect of Functionalized MWCNTs/poly (L-lactide-co-ε-caprolactone) Nanocomposites. Supervisor: Prof. Wei Cai,\r\n•\tM.Sc in Applied Physics, From: 1996, to: 1998, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Determination of Boron in Micro alloy Steels with solid state nuclear track detectors by neutron induced auto radiography, Supervisors: Dr. M. Hosseini Ashrafi and Dr. A. Hosseini.\r\n•\tB.Sc. in Applied Physics, From: 1991, to: 1996, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Design of shielding for Am-Be neutron sources for In Vivo neutron activation analysis, Supervisor: Dr. M. Hosseini Ashrafi.\r\n\r\nResearch Experiences:\r\n1.\tNanomaterials, Carbon Nanotubes, Graphene: Synthesis, Functionalization and Characterization,\r\n2.\tMWCNTs/Polymer Composites: Fabrication and Characterization, \r\n3.\tShape Memory Polymers, Biodegradable Polymers, ORC, Collagen,\r\n4.\tMaterials Analysis and Characterizations: TEM, SEM, XPS, FT-IR, Raman, DSC, DMA, TGA, XRD, GPC, Fluoroscopy, \r\n5.\tInteraction of Radiation with Mater, Nuclear Safety and Security, NDT(RT),\r\n6.\tRadiation Detectors, Calibration (SSDL),\r\n7.\tCompleted IAEA e-learning Courses:\r\nNuclear Security (15 Modules),\r\nNuclear Safety:\r\nTSA 2: Regulatory Protection in Occupational Exposure,\r\nTips & Tricks: Radiation Protection in Radiography,\r\nSafety and Quality in Radiotherapy,\r\nCourse on Sealed Radioactive Sources,\r\nCourse on Fundamentals of Environmental Remediation,\r\nCourse on Planning for Environmental Remediation,\r\nKnowledge Management Orientation Course,\r\nFood Irradiation - Technology, Applications and Good Practices,\r\nEmployment:\r\nFrom 2010 to now: Academic staff, Nuclear Science and Technology Research Institute, Kargar Shomali, Tehran, Iran, P.O. Box: 14395-836.\r\nFrom 1997 to 2006: Expert of Materials Analysis and Characterization. Research Center of Agriculture and Medicine. Rajaeeshahr, Karaj, Iran, P. O. Box: 31585-498.",institutionString:"Atomic Energy Organization of Iran",institution:{name:"Atomic Energy Organization of Iran",country:{name:"Iran"}}},{id:"248279",title:"Dr.",name:"Monika",middleName:"Elzbieta",surname:"Machoy",slug:"monika-machoy",fullName:"Monika Machoy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248279/images/system/248279.jpeg",biography:"Monika Elżbieta Machoy, MD, graduated with distinction from the Faculty of Medicine and Dentistry at the Pomeranian Medical University in 2009, defended her PhD thesis with summa cum laude in 2016 and is currently employed as a researcher at the Department of Orthodontics of the Pomeranian Medical University. She expanded her professional knowledge during a one-year scholarship program at the Ernst Moritz Arndt University in Greifswald, Germany and during a three-year internship at the Technical University in Dresden, Germany. She has been a speaker at numerous orthodontic conferences, among others, American Association of Orthodontics, European Orthodontic Symposium and numerous conferences of the Polish Orthodontic Society. She conducts research focusing on the effect of orthodontic treatment on dental and periodontal tissues and the causes of pain in orthodontic patients.",institutionString:"Pomeranian Medical University",institution:{name:"Pomeranian Medical University",country:{name:"Poland"}}},{id:"252743",title:"Prof.",name:"Aswini",middleName:"Kumar",surname:"Kar",slug:"aswini-kar",fullName:"Aswini Kar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252743/images/10381_n.jpg",biography:"uploaded in cv",institutionString:null,institution:{name:"KIIT University",country:{name:"India"}}},{id:"204256",title:"Dr.",name:"Anil",middleName:"Kumar",surname:"Kumar Sahu",slug:"anil-kumar-sahu",fullName:"Anil Kumar Sahu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204256/images/14201_n.jpg",biography:"I have nearly 11 years of research and teaching experience. I have done my master degree from University Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur, Chhattisgarh India. I have published 16 review and research articles in international and national journals and published 4 chapters in IntechOpen, the world’s leading publisher of Open access books. I have presented many papers at national and international conferences. I have received research award from Indian Drug Manufacturers Association in year 2015. My research interest extends from novel lymphatic drug delivery systems, oral delivery system for herbal bioactive to formulation optimization.",institutionString:null,institution:{name:"Chhattisgarh Swami Vivekanand Technical University",country:{name:"India"}}},{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",biography:"An assistant professor at Department of Biomedical Computer Systems, at Institute of Computer Science, Silesian University in Katowice. Scientific interests: computer analysis and processing of images, biomedical images, databases and programming languages. He is an author and co-author of scientific publications covering analysis and processing of biomedical images and development of database systems.",institutionString:"University of Silesia",institution:{name:"University of Silesia",country:{name:"Poland"}}},{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",biography:"Dr. Hadi Mohammadi is a biomedical engineer with hands-on experience in the design and development of many engineering structures and medical devices through various projects that he has been involved in over the past twenty years. Dr. Mohammadi received his BSc. and MSc. degrees in Mechanical Engineering from Sharif University of Technology, Tehran, Iran, and his PhD. degree in Biomedical Engineering (biomaterials) from the University of Western Ontario. He was a postdoctoral trainee for almost four years at University of Calgary and Harvard Medical School. He is an industry innovator having created the technology to produce lifelike synthetic platforms that can be used for the simulation of almost all cardiovascular reconstructive surgeries. He’s been heavily involved in the design and development of cardiovascular devices and technology for the past 10 years. He is currently an Assistant Professor with the University of British Colombia, Canada.",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",country:{name:"Canada"}}},{id:"254463",title:"Prof.",name:"Haisheng",middleName:null,surname:"Yang",slug:"haisheng-yang",fullName:"Haisheng Yang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/254463/images/system/254463.jpeg",biography:"Haisheng Yang, Ph.D., Professor and Director of the Department of Biomedical Engineering, College of Life Science and Bioengineering, Beijing University of Technology. He received his Ph.D. degree in Mechanics/Biomechanics from Harbin Institute of Technology (jointly with University of California, Berkeley). Afterwards, he worked as a Postdoctoral Research Associate in the Purdue Musculoskeletal Biology and Mechanics Lab at the Department of Basic Medical Sciences, Purdue University, USA. He also conducted research in the Research Centre of Shriners Hospitals for Children-Canada at McGill University, Canada. Dr. Yang has over 10 years research experience in orthopaedic biomechanics and mechanobiology of bone adaptation and regeneration. He earned an award from Beijing Overseas Talents Aggregation program in 2017 and serves as Beijing Distinguished Professor.",institutionString:null,institution:{name:"Beijing University of Technology",country:{name:"China"}}},{id:"89721",title:"Dr.",name:"Mehmet",middleName:"Cuneyt",surname:"Ozmen",slug:"mehmet-ozmen",fullName:"Mehmet Ozmen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/89721/images/7289_n.jpg",biography:null,institutionString:null,institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"265335",title:"Mr.",name:"Stefan",middleName:"Radnev",surname:"Stefanov",slug:"stefan-stefanov",fullName:"Stefan Stefanov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/265335/images/7562_n.jpg",biography:null,institutionString:null,institution:{name:"Medical University Plovdiv",country:{name:"Bulgaria"}}},{id:"242893",title:"Ph.D. Student",name:"Joaquim",middleName:null,surname:"De Moura",slug:"joaquim-de-moura",fullName:"Joaquim De Moura",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/242893/images/7133_n.jpg",biography:"Joaquim de Moura received his degree in Computer Engineering in 2014 from the University of A Coruña (Spain). In 2016, he received his M.Sc degree in Computer Engineering from the same university. He is currently pursuing his Ph.D degree in Computer Science in a collaborative project between ophthalmology centers in Galicia and the University of A Coruña. His research interests include computer vision, machine learning algorithms and analysis and medical imaging processing of various kinds.",institutionString:null,institution:{name:"University of A Coruña",country:{name:"Spain"}}},{id:"294334",title:"B.Sc.",name:"Marc",middleName:null,surname:"Bruggeman",slug:"marc-bruggeman",fullName:"Marc Bruggeman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/294334/images/8242_n.jpg",biography:"Chemical engineer graduate, with a passion for material science and specific interest in polymers - their near infinite applications intrigue me. \n\nI plan to continue my scientific career in the field of polymeric biomaterials as I am fascinated by intelligent, bioactive and biomimetic materials for use in both consumer and medical applications.",institutionString:null,institution:null},{id:"255757",title:"Dr.",name:"Igor",middleName:"Victorovich",surname:"Lakhno",slug:"igor-lakhno",fullName:"Igor Lakhno",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255757/images/system/255757.jpg",biography:"Igor Victorovich Lakhno was born in 1971 in Kharkiv (Ukraine). \nMD – 1994, Kharkiv National Medical Univesity.\nOb&Gyn; – 1997, master courses in Kharkiv Medical Academy of Postgraduate Education.\nPh.D. – 1999, Kharkiv National Medical Univesity.\nDSC – 2019, PL Shupik National Academy of Postgraduate Education \nProfessor – 2021, Department of Obstetrics and Gynecology of VN Karazin Kharkiv National University\nHead of Department – 2021, Department of Perinatology, Obstetrics and gynecology of Kharkiv Medical Academy of Postgraduate Education\nIgor Lakhno has been graduated from international training courses on reproductive medicine and family planning held at Debrecen University (Hungary) in 1997. Since 1998 Lakhno Igor has worked as an associate professor in the department of obstetrics and gynecology of VN Karazin National University and an associate professor of the perinatology, obstetrics, and gynecology department of Kharkiv Medical Academy of Postgraduate Education. Since June 2019 he’s been a professor in the department of obstetrics and gynecology of VN Karazin National University and a professor of the perinatology, obstetrics, and gynecology department. He’s affiliated with Kharkiv Medical Academy of Postgraduate Education as a Head of Department from November 2021. Igor Lakhno has participated in several international projects on fetal non-invasive electrocardiography (with Dr. J. A. Behar (Technion), Prof. D. Hoyer (Jena University), and José Alejandro Díaz Méndez (National Institute of Astrophysics, Optics, and Electronics, Mexico). He’s an author of about 200 printed works and there are 31 of them in Scopus or Web of Science databases. Igor Lakhno is a member of the Editorial Board of Reproductive Health of Woman, Emergency Medicine, and Technology Transfer Innovative Solutions in Medicine (Estonia). He is a medical Editor of “Z turbotoyu pro zhinku”. Igor Lakhno is a reviewer of the Journal of Obstetrics and Gynaecology (Taylor and Francis), British Journal of Obstetrics and Gynecology (Wiley), Informatics in Medicine Unlocked (Elsevier), The Journal of Obstetrics and Gynecology Research (Wiley), Endocrine, Metabolic & Immune Disorders-Drug Targets (Bentham Open), The Open Biomedical Engineering Journal (Bentham Open), etc. He’s defended a dissertation for a DSc degree “Pre-eclampsia: prediction, prevention, and treatment”. Three years ago Igor Lakhno has participated in a training course on innovative technologies in medical education at Lublin Medical University (Poland). Lakhno Igor has participated as a speaker in several international conferences and congresses (International Conference on Biological Oscillations April 10th-14th 2016, Lancaster, UK, The 9th conference of the European Study Group on Cardiovascular Oscillations). His main scientific interests: are obstetrics, women’s health, fetal medicine, and cardiovascular medicine. \nIgor Lakhno is a consultant at Kharkiv municipal perinatal center. He’s graduated from training courses on endoscopy in gynecology. He has 28 years of practical experience in the field.",institutionString:null,institution:null},{id:"244950",title:"Dr.",name:"Salvatore",middleName:null,surname:"Di Lauro",slug:"salvatore-di-lauro",fullName:"Salvatore Di Lauro",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0030O00002bSF1HQAW/ProfilePicture%202021-12-20%2014%3A54%3A14.482",biography:"Name:\n\tSALVATORE DI LAURO\nAddress:\n\tHospital Clínico Universitario Valladolid\nAvda Ramón y Cajal 3\n47005, Valladolid\nSpain\nPhone number: \nFax\nE-mail:\n\t+34 983420000 ext 292\n+34 983420084\nsadilauro@live.it\nDate and place of Birth:\nID Number\nMedical Licence \nLanguages\t09-05-1985. Villaricca (Italy)\n\nY1281863H\n474707061\nItalian (native language)\nSpanish (read, written, spoken)\nEnglish (read, written, spoken)\nPortuguese (read, spoken)\nFrench (read)\n\t\t\nCurrent position (title and company)\tDate (Year)\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. Private practise.\t2017-today\n\n2019-today\n\t\n\t\nEducation (High school, university and postgraduate training > 3 months)\tDate (Year)\nDegree in Medicine and Surgery. University of Neaples 'Federico II”\nResident in Opthalmology. Hospital Clinico Universitario Valladolid\nMaster in Vitreo-Retina. IOBA. University of Valladolid\nFellow of the European Board of Ophthalmology. Paris\nMaster in Research in Ophthalmology. University of Valladolid\t2003-2009\n2012-2016\n2016-2017\n2016\n2012-2013\n\t\nEmployments (company and positions)\tDate (Year)\nResident in Ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl.\nFellow in Vitreo-Retina. IOBA. University of Valladolid\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. \n\t2012-2016\n2016-2017\n2017-today\n\n2019-Today\n\n\n\t\nClinical Research Experience (tasks and role)\tDate (Year)\nAssociated investigator\n\n' FIS PI20/00740: DESARROLLO DE UNA CALCULADORA DE RIESGO DE\nAPARICION DE RETINOPATIA DIABETICA BASADA EN TECNICAS DE IMAGEN MULTIMODAL EN PACIENTES DIABETICOS TIPO 1. Grant by: Ministerio de Ciencia e Innovacion \n\n' (BIO/VA23/14) Estudio clínico multicéntrico y prospectivo para validar dos\nbiomarcadores ubicados en los genes p53 y MDM2 en la predicción de los resultados funcionales de la cirugía del desprendimiento de retina regmatógeno. Grant by: Gerencia Regional de Salud de la Junta de Castilla y León.\n' Estudio multicéntrico, aleatorizado, con enmascaramiento doble, en 2 grupos\nparalelos y de 52 semanas de duración para comparar la eficacia, seguridad e inmunogenicidad de SOK583A1 respecto a Eylea® en pacientes con degeneración macular neovascular asociada a la edad' (CSOK583A12301; N.EUDRA: 2019-004838-41; FASE III). Grant by Hexal AG\n\n' Estudio de fase III, aleatorizado, doble ciego, con grupos paralelos, multicéntrico para comparar la eficacia y la seguridad de QL1205 frente a Lucentis® en pacientes con degeneración macular neovascular asociada a la edad. (EUDRACT: 2018-004486-13). Grant by Qilu Pharmaceutical Co\n\n' Estudio NEUTON: Ensayo clinico en fase IV para evaluar la eficacia de aflibercept en pacientes Naive con Edema MacUlar secundario a Oclusion de Vena CenTral de la Retina (OVCR) en regimen de tratamientO iNdividualizado Treat and Extend (TAE)”, (2014-000975-21). Grant by Fundacion Retinaplus\n\n' Evaluación de la seguridad y bioactividad de anillos de tensión capsular en conejo. Proyecto Procusens. Grant by AJL, S.A.\n\n'Estudio epidemiológico, prospectivo, multicéntrico y abierto\\npara valorar la frecuencia de la conjuntivitis adenovírica diagnosticada mediante el test AdenoPlus®\\nTest en pacientes enfermos de conjuntivitis aguda”\\n. National, multicenter study. Grant by: NICOX.\n\nEuropean multicentric trial: 'Evaluation of clinical outcomes following the use of Systane Hydration in patients with dry eye”. Study Phase 4. Grant by: Alcon Labs'\n\nVLPs Injection and Activation in a Rabbit Model of Uveal Melanoma. Grant by Aura Bioscience\n\nUpdating and characterization of a rabbit model of uveal melanoma. Grant by Aura Bioscience\n\nEnsayo clínico en fase IV para evaluar las variantes genéticas de la vía del VEGF como biomarcadores de eficacia del tratamiento con aflibercept en pacientes con degeneración macular asociada a la edad (DMAE) neovascular. Estudio BIOIMAGE. IMO-AFLI-2013-01\n\nEstudio In-Eye:Ensayo clínico en fase IV, abierto, aleatorizado, de 2 brazos,\nmulticçentrico y de 12 meses de duración, para evaluar la eficacia y seguridad de un régimen de PRN flexible individualizado de 'esperar y extender' versus un régimen PRN según criterios de estabilización mediante evaluaciones mensuales de inyecciones intravítreas de ranibizumab 0,5 mg en pacientes naive con neovascularización coriodea secunaria a la degeneración macular relacionada con la edad. CP: CRFB002AES03T\n\nTREND: Estudio Fase IIIb multicéntrico, randomizado, de 12 meses de\nseguimiento con evaluador de la agudeza visual enmascarado, para evaluar la eficacia y la seguridad de ranibizumab 0.5mg en un régimen de tratar y extender comparado con un régimen mensual, en pacientes con degeneración macular neovascular asociada a la edad. CP: CRFB002A2411 Código Eudra CT:\n2013-002626-23\n\n\n\nPublications\t\n\n2021\n\n\n\n\n2015\n\n\n\n\n2021\n\n\n\n\n\n2021\n\n\n\n\n2015\n\n\n\n\n2015\n\n\n2014\n\n\n\n\n2015-16\n\n\n\n2015\n\n\n2014\n\n\n2014\n\n\n\n\n2014\n\n\n\n\n\n\n\n2014\n\nJose Carlos Pastor; Jimena Rojas; Salvador Pastor-Idoate; Salvatore Di Lauro; Lucia Gonzalez-Buendia; Santiago Delgado-Tirado. Proliferative vitreoretinopathy: A new concept of disease pathogenesis and practical\nconsequences. Progress in Retinal and Eye Research. 51, pp. 125 - 155. 03/2016. DOI: 10.1016/j.preteyeres.2015.07.005\n\n\nLabrador-Velandia S; Alonso-Alonso ML; Di Lauro S; García-Gutierrez MT; Srivastava GK; Pastor JC; Fernandez-Bueno I. Mesenchymal stem cells provide paracrine neuroprotective resources that delay degeneration of co-cultured organotypic neuroretinal cultures.Experimental Eye Research. 185, 17/05/2019. DOI: 10.1016/j.exer.2019.05.011\n\nSalvatore Di Lauro; Maria Teresa Garcia Gutierrez; Ivan Fernandez Bueno. Quantification of pigment epithelium-derived factor (PEDF) in an ex vivo coculture of retinal pigment epithelium cells and neuroretina.\nJournal of Allbiosolution. 2019. ISSN 2605-3535\n\nSonia Labrador Velandia; Salvatore Di Lauro; Alonso-Alonso ML; Tabera Bartolomé S; Srivastava GK; Pastor JC; Fernandez-Bueno I. Biocompatibility of intravitreal injection of human mesenchymal stem cells in immunocompetent rabbits. Graefe's archive for clinical and experimental ophthalmology. 256 - 1, pp. 125 - 134. 01/2018. DOI: 10.1007/s00417-017-3842-3\n\n\nSalvatore Di Lauro, David Rodriguez-Crespo, Manuel J Gayoso, Maria T Garcia-Gutierrez, J Carlos Pastor, Girish K Srivastava, Ivan Fernandez-Bueno. A novel coculture model of porcine central neuroretina explants and retinal pigment epithelium cells. Molecular Vision. 2016 - 22, pp. 243 - 253. 01/2016.\n\nSalvatore Di Lauro. Classifications for Proliferative Vitreoretinopathy ({PVR}): An Analysis of Their Use in Publications over the Last 15 Years. Journal of Ophthalmology. 2016, pp. 1 - 6. 01/2016. DOI: 10.1155/2016/7807596\n\nSalvatore Di Lauro; Rosa Maria Coco; Rosa Maria Sanabria; Enrique Rodriguez de la Rua; Jose Carlos Pastor. Loss of Visual Acuity after Successful Surgery for Macula-On Rhegmatogenous Retinal Detachment in a Prospective Multicentre Study. Journal of Ophthalmology. 2015:821864, 2015. DOI: 10.1155/2015/821864\n\nIvan Fernandez-Bueno; Salvatore Di Lauro; Ivan Alvarez; Jose Carlos Lopez; Maria Teresa Garcia-Gutierrez; Itziar Fernandez; Eva Larra; Jose Carlos Pastor. Safety and Biocompatibility of a New High-Density Polyethylene-Based\nSpherical Integrated Porous Orbital Implant: An Experimental Study in Rabbits. Journal of Ophthalmology. 2015:904096, 2015. DOI: 10.1155/2015/904096\n\nPastor JC; Pastor-Idoate S; Rodríguez-Hernandez I; Rojas J; Fernandez I; Gonzalez-Buendia L; Di Lauro S; Gonzalez-Sarmiento R. Genetics of PVR and RD. Ophthalmologica. 232 - Suppl 1, pp. 28 - 29. 2014\n\nRodriguez-Crespo D; Di Lauro S; Singh AK; Garcia-Gutierrez MT; Garrosa M; Pastor JC; Fernandez-Bueno I; Srivastava GK. Triple-layered mixed co-culture model of RPE cells with neuroretina for evaluating the neuroprotective effects of adipose-MSCs. Cell Tissue Res. 358 - 3, pp. 705 - 716. 2014.\nDOI: 10.1007/s00441-014-1987-5\n\nCarlo De Werra; Salvatore Condurro; Salvatore Tramontano; Mario Perone; Ivana Donzelli; Salvatore Di Lauro; Massimo Di Giuseppe; Rosa Di Micco; Annalisa Pascariello; Antonio Pastore; Giorgio Diamantis; Giuseppe Galloro. Hydatid disease of the liver: thirty years of surgical experience.Chirurgia italiana. 59 - 5, pp. 611 - 636.\n(Italia): 2007. ISSN 0009-4773\n\nChapters in books\n\t\n' Salvador Pastor Idoate; Salvatore Di Lauro; Jose Carlos Pastor Jimeno. PVR: Pathogenesis, Histopathology and Classification. Proliferative Vitreoretinopathy with Small Gauge Vitrectomy. Springer, 2018. ISBN 978-3-319-78445-8\nDOI: 10.1007/978-3-319-78446-5_2. \n\n' Salvatore Di Lauro; Maria Isabel Lopez Galvez. Quistes vítreos en una mujer joven. Problemas diagnósticos en patología retinocoroidea. Sociedad Española de Retina-Vitreo. 2018.\n\n' Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor Jimeno. iOCT in PVR management. OCT Applications in Opthalmology. pp. 1 - 8. INTECH, 2018. DOI: 10.5772/intechopen.78774.\n\n' Rosa Coco Martin; Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor. amponadores, manipuladores y tinciones en la cirugía del traumatismo ocular.Trauma Ocular. Ponencia de la SEO 2018..\n\n' LOPEZ GALVEZ; DI LAURO; CRESPO. OCT angiografia y complicaciones retinianas de la diabetes. PONENCIA SEO 2021, CAPITULO 20. (España): 2021.\n\n' Múltiples desprendimientos neurosensoriales bilaterales en paciente joven. Enfermedades Degenerativas De Retina Y Coroides. SERV 04/2016. \n' González-Buendía L; Di Lauro S; Pastor-Idoate S; Pastor Jimeno JC. Vitreorretinopatía proliferante (VRP) e inflamación: LA INFLAMACIÓN in «INMUNOMODULADORES Y ANTIINFLAMATORIOS: MÁS ALLÁ DE LOS CORTICOIDES. RELACION DE PONENCIAS DE LA SOCIEDAD ESPAÑOLA DE OFTALMOLOGIA. 10/2014.",institutionString:null,institution:null},{id:"243698",title:"Dr.",name:"Xiaogang",middleName:null,surname:"Wang",slug:"xiaogang-wang",fullName:"Xiaogang Wang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243698/images/system/243698.png",biography:"Dr. Xiaogang Wang, a faculty member of Shanxi Eye Hospital specializing in the treatment of cataract and retinal disease and a tutor for postgraduate students of Shanxi Medical University, worked in the COOL Lab as an international visiting scholar under the supervision of Dr. David Huang and Yali Jia from October 2012 through November 2013. Dr. Wang earned an MD from Shanxi Medical University and a Ph.D. from Shanghai Jiao Tong University. Dr. Wang was awarded two research project grants focused on multimodal optical coherence tomography imaging and deep learning in cataract and retinal disease, from the National Natural Science Foundation of China. He has published around 30 peer-reviewed journal papers and four book chapters and co-edited one book.",institutionString:null,institution:null},{id:"7227",title:"Dr.",name:"Hiroaki",middleName:null,surname:"Matsui",slug:"hiroaki-matsui",fullName:"Hiroaki Matsui",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Tokyo",country:{name:"Japan"}}},{id:"312999",title:"Dr.",name:"Bernard O.",middleName:null,surname:"Asimeng",slug:"bernard-o.-asimeng",fullName:"Bernard O. Asimeng",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Ghana",country:{name:"Ghana"}}},{id:"318905",title:"Prof.",name:"Elvis",middleName:"Kwason",surname:"Tiburu",slug:"elvis-tiburu",fullName:"Elvis Tiburu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Ghana",country:{name:"Ghana"}}},{id:"336193",title:"Dr.",name:"Abdullah",middleName:null,surname:"Alamoudi",slug:"abdullah-alamoudi",fullName:"Abdullah Alamoudi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"318657",title:"MSc.",name:"Isabell",middleName:null,surname:"Steuding",slug:"isabell-steuding",fullName:"Isabell Steuding",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Harz University of Applied Sciences",country:{name:"Germany"}}},{id:"318656",title:"BSc.",name:"Peter",middleName:null,surname:"Kußmann",slug:"peter-kussmann",fullName:"Peter Kußmann",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Harz University of Applied Sciences",country:{name:"Germany"}}}]}},subseries:{item:{id:"17",type:"subseries",title:"Metabolism",keywords:"Biomolecules Metabolism, Energy Metabolism, Metabolic Pathways, Key Metabolic Enzymes, Metabolic Adaptation",scope:"Metabolism is frequently defined in biochemistry textbooks as the overall process that allows living systems to acquire and use the free energy they need for their vital functions or the chemical processes that occur within a living organism to maintain life. Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. Thus all studies on metabolism will be considered for publication.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11413,editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",slug:"yannis-karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",biography:"Yannis Karamanos, born in Greece in 1953, completed his pre-graduate studies at the Université Pierre et Marie Curie, Paris, then his Masters and Doctoral degree at the Université de Lille (1983). He was associate professor at the University of Limoges (1987) before becoming full professor of biochemistry at the Université d’Artois (1996). He worked on the structure-function relationships of glycoconjugates and his main project was the investigations on the biological roles of the de-N-glycosylation enzymes (Endo-N-acetyl-β-D-glucosaminidase and peptide-N4-(N-acetyl-β-glucosaminyl) asparagine amidase). From 2002 he contributes to the understanding of the Blood-brain barrier functioning using proteomics approaches. He has published more than 70 papers. His teaching areas are energy metabolism and regulation, integration and organ specialization and metabolic adaptation.",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null,series:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983"},editorialBoard:[{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",slug:"anca-pantea-stoian",fullName:"Anca Pantea Stoian",profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"203824",title:"Dr.",name:"Attilio",middleName:null,surname:"Rigotti",slug:"attilio-rigotti",fullName:"Attilio Rigotti",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institutionString:null,institution:{name:"Pontifical Catholic University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"300470",title:"Dr.",name:"Yanfei (Jacob)",middleName:null,surname:"Qi",slug:"yanfei-(jacob)-qi",fullName:"Yanfei (Jacob) Qi",profilePictureURL:"https://mts.intechopen.com/storage/users/300470/images/system/300470.jpg",institutionString:null,institution:{name:"Centenary Institute of Cancer Medicine and Cell Biology",institutionURL:null,country:{name:"Australia"}}}]},onlineFirstChapters:{paginationCount:0,paginationItems:[]},publishedBooks:{paginationCount:5,paginationItems:[{type:"book",id:"8737",title:"Rabies Virus at the Beginning of 21st Century",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/8737.jpg",slug:"rabies-virus-at-the-beginning-of-21st-century",publishedDate:"May 11th 2022",editedByType:"Edited by",bookSignature:"Sergey Tkachev",hash:"49cce3f548da548c718c865feb343509",volumeInSeries:9,fullTitle:"Rabies Virus at the Beginning of 21st Century",editors:[{id:"61139",title:"Dr.",name:"Sergey",middleName:null,surname:"Tkachev",slug:"sergey-tkachev",fullName:"Sergey Tkachev",profilePictureURL:"https://mts.intechopen.com/storage/users/61139/images/system/61139.png",institutionString:"Russian Academy of Sciences",institution:{name:"Russian Academy of Sciences",institutionURL:null,country:{name:"Russia"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"10497",title:"Canine Genetics, Health and Medicine",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/10497.jpg",slug:"canine-genetics-health-and-medicine",publishedDate:"June 2nd 2021",editedByType:"Edited by",bookSignature:"Catrin Rutland",hash:"b91512e31ce34032e560362e6cbccc1c",volumeInSeries:7,fullTitle:"Canine Genetics, Health and Medicine",editors:[{id:"202192",title:"Dr.",name:"Catrin",middleName:null,surname:"Rutland",slug:"catrin-rutland",fullName:"Catrin Rutland",profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",institutionString:null,institution:{name:"University of Nottingham",institutionURL:null,country:{name:"United Kingdom"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9081",title:"Equine Science",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9081.jpg",slug:"equine-science",publishedDate:"September 23rd 2020",editedByType:"Edited by",bookSignature:"Catrin Rutland and Albert Rizvanov",hash:"ac415ef2f5450fa80fdb9cf6cf32cd2d",volumeInSeries:5,fullTitle:"Equine Science",editors:[{id:"202192",title:"Dr.",name:"Catrin",middleName:null,surname:"Rutland",slug:"catrin-rutland",fullName:"Catrin Rutland",profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",institutionString:null,institution:{name:"University of Nottingham",institutionURL:null,country:{name:"United Kingdom"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8524",title:"Lactation in Farm Animals",subtitle:"Biology, Physiological Basis, Nutritional Requirements, and Modelization",coverURL:"https://cdn.intechopen.com/books/images_new/8524.jpg",slug:"lactation-in-farm-animals-biology-physiological-basis-nutritional-requirements-and-modelization",publishedDate:"January 22nd 2020",editedByType:"Edited by",bookSignature:"Naceur M'Hamdi",hash:"2aa2a9a0ec13040bbf0455e34625504e",volumeInSeries:3,fullTitle:"Lactation in Farm Animals - Biology, Physiological Basis, Nutritional Requirements, and Modelization",editors:[{id:"73376",title:"Dr.",name:"Naceur",middleName:null,surname:"M'Hamdi",slug:"naceur-m'hamdi",fullName:"Naceur M'Hamdi",profilePictureURL:"https://mts.intechopen.com/storage/users/73376/images/system/73376.jpg",institutionString:null,institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7144",title:"Veterinary Anatomy and Physiology",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7144.jpg",slug:"veterinary-anatomy-and-physiology",publishedDate:"March 13th 2019",editedByType:"Edited by",bookSignature:"Catrin Sian Rutland and Valentina Kubale",hash:"75cdacb570e0e6d15a5f6e69640d87c9",volumeInSeries:2,fullTitle:"Veterinary Anatomy and Physiology",editors:[{id:"202192",title:"Dr.",name:"Catrin",middleName:null,surname:"Rutland",slug:"catrin-rutland",fullName:"Catrin Rutland",profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",institutionString:null,institution:{name:"University of Nottingham",institutionURL:null,country:{name:"United Kingdom"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},testimonialsList:[{id:"18",text:"It was great publishing with IntechOpen, the process was straightforward and I had support all along.",author:{id:"71579",name:"Berend",surname:"Olivier",institutionString:"Utrecht University",profilePictureURL:"https://mts.intechopen.com/storage/users/71579/images/system/71579.png",slug:"berend-olivier",institution:{id:"253",name:"Utrecht University",country:{id:null,name:"Netherlands"}}}},{id:"8",text:"I work with IntechOpen for a number of reasons: their professionalism, their mission in support of Open Access publishing, and the quality of their peer-reviewed publications, but also because they believe in equality.",author:{id:"202192",name:"Catrin",surname:"Rutland",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",slug:"catrin-rutland",institution:{id:"134",name:"University of Nottingham",country:{id:null,name:"United Kingdom"}}}},{id:"27",text:"The opportunity to work with a prestigious publisher allows for the possibility to collaborate with more research groups interested in animal nutrition, leading to the development of new feeding strategies and food valuation while being more sustainable with the environment, allowing more readers to learn about the subject.",author:{id:"175967",name:"Manuel",surname:"Gonzalez Ronquillo",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/175967/images/system/175967.png",slug:"manuel-gonzalez-ronquillo",institution:{id:"6221",name:"Universidad Autónoma del Estado de México",country:{id:null,name:"Mexico"}}}}]},submityourwork:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:139,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:122,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:21,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:10,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],subseriesList:[],annualVolumeBook:{},thematicCollection:[],selectedSeries:null,selectedSubseries:null},seriesLanding:{item:{id:"7",title:"Biomedical Engineering",doi:"10.5772/intechopen.71985",issn:"2631-5343",scope:"Biomedical Engineering is one of the fastest-growing interdisciplinary branches of science and industry. The combination of electronics and computer science with biology and medicine has improved patient diagnosis, reduced rehabilitation time, and helped to facilitate a better quality of life. Nowadays, all medical imaging devices, medical instruments, or new laboratory techniques result from the cooperation of specialists in various fields. The series of Biomedical Engineering books covers such areas of knowledge as chemistry, physics, electronics, medicine, and biology. This series is intended for doctors, engineers, and scientists involved in biomedical engineering or those wanting to start working in this field.",coverUrl:"https://cdn.intechopen.com/series/covers/7.jpg",latestPublicationDate:"August 3rd, 2022",hasOnlineFirst:!0,numberOfOpenTopics:3,numberOfPublishedChapters:107,numberOfPublishedBooks:12,editor:{id:"50150",title:"Prof.",name:"Robert",middleName:null,surname:"Koprowski",fullName:"Robert Koprowski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYTYNQA4/Profile_Picture_1630478535317",biography:"Robert Koprowski, MD (1997), PhD (2003), Habilitation (2015), is an employee of the University of Silesia, Poland, Institute of Computer Science, Department of Biomedical Computer Systems. For 20 years, he has studied the analysis and processing of biomedical images, emphasizing the full automation of measurement for a large inter-individual variability of patients. Dr. Koprowski has authored more than a hundred research papers with dozens in impact factor (IF) journals and has authored or co-authored six books. Additionally, he is the author of several national and international patents in the field of biomedical devices and imaging. Since 2011, he has been a reviewer of grants and projects (including EU projects) in biomedical engineering.",institutionString:null,institution:{name:"University of Silesia",institutionURL:null,country:{name:"Poland"}}},subseries:[{id:"7",title:"Bioinformatics and Medical Informatics",keywords:"Biomedical Data, Drug Discovery, Clinical Diagnostics, Decoding Human Genome, AI in Personalized Medicine, Disease-prevention Strategies, Big Data Analysis in Medicine",scope:"Bioinformatics aims to help understand the functioning of the mechanisms of living organisms through the construction and use of quantitative tools. The applications of this research cover many related fields, such as biotechnology and medicine, where, for example, Bioinformatics contributes to faster drug design, DNA analysis in forensics, and DNA sequence analysis in the field of personalized medicine. Personalized medicine is a type of medical care in which treatment is customized individually for each patient. Personalized medicine enables more effective therapy, reduces the costs of therapy and clinical trials, and also minimizes the risk of side effects. Nevertheless, advances in personalized medicine would not have been possible without bioinformatics, which can analyze the human genome and other vast amounts of biomedical data, especially in genetics. The rapid growth of information technology enabled the development of new tools to decode human genomes, large-scale studies of genetic variations and medical informatics. The considerable development of technology, including the computing power of computers, is also conducive to the development of bioinformatics, including personalized medicine. In an era of rapidly growing data volumes and ever lower costs of generating, storing and computing data, personalized medicine holds great promises. Modern computational methods used as bioinformatics tools can integrate multi-scale, multi-modal and longitudinal patient data to create even more effective and safer therapy and disease prevention methods. Main aspects of the topic are: Applying bioinformatics in drug discovery and development; Bioinformatics in clinical diagnostics (genetic variants that act as markers for a condition or a disease); Blockchain and Artificial Intelligence/Machine Learning in personalized medicine; Customize disease-prevention strategies in personalized medicine; Big data analysis in personalized medicine; Translating stratification algorithms into clinical practice of personalized medicine.",annualVolume:11403,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/7.jpg",editor:{id:"351533",title:"Dr.",name:"Slawomir",middleName:null,surname:"Wilczynski",fullName:"Slawomir Wilczynski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035U1loQAC/Profile_Picture_1630074514792",institutionString:null,institution:{name:"Medical University of Silesia",institutionURL:null,country:{name:"Poland"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"5886",title:"Dr.",name:"Alexandros",middleName:"T.",surname:"Tzallas",fullName:"Alexandros Tzallas",profilePictureURL:"https://mts.intechopen.com/storage/users/5886/images/system/5886.png",institutionString:"University of Ioannina, Greece & Imperial College London",institution:{name:"University of Ioannina",institutionURL:null,country:{name:"Greece"}}},{id:"257388",title:"Distinguished Prof.",name:"Lulu",middleName:null,surname:"Wang",fullName:"Lulu Wang",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRX6kQAG/Profile_Picture_1630329584194",institutionString:"Shenzhen Technology University",institution:{name:"Shenzhen Technology University",institutionURL:null,country:{name:"China"}}},{id:"225387",title:"Prof.",name:"Reda R.",middleName:"R.",surname:"Gharieb",fullName:"Reda R. Gharieb",profilePictureURL:"https://mts.intechopen.com/storage/users/225387/images/system/225387.jpg",institutionString:"Assiut University",institution:{name:"Assiut University",institutionURL:null,country:{name:"Egypt"}}}]},{id:"8",title:"Bioinspired Technology and Biomechanics",keywords:"Bioinspired Systems, Biomechanics, Assistive Technology, Rehabilitation",scope:'Bioinspired technologies take advantage of understanding the actual biological system to provide solutions to problems in several areas. Recently, bioinspired systems have been successfully employing biomechanics to develop and improve assistive technology and rehabilitation devices. The research topic "Bioinspired Technology and Biomechanics" welcomes studies reporting recent advances in bioinspired technologies that contribute to individuals\' health, inclusion, and rehabilitation. Possible contributions can address (but are not limited to) the following research topics: Bioinspired design and control of exoskeletons, orthoses, and prostheses; Experimental evaluation of the effect of assistive devices (e.g., influence on gait, balance, and neuromuscular system); Bioinspired technologies for rehabilitation, including clinical studies reporting evaluations; Application of neuromuscular and biomechanical models to the development of bioinspired technology.',annualVolume:11404,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/8.jpg",editor:{id:"144937",title:"Prof.",name:"Adriano",middleName:"De Oliveira",surname:"Andrade",fullName:"Adriano Andrade",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRC8QQAW/Profile_Picture_1625219101815",institutionString:null,institution:{name:"Federal University of Uberlândia",institutionURL:null,country:{name:"Brazil"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"49517",title:"Prof.",name:"Hitoshi",middleName:null,surname:"Tsunashima",fullName:"Hitoshi Tsunashima",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYTP4QAO/Profile_Picture_1625819726528",institutionString:null,institution:{name:"Nihon University",institutionURL:null,country:{name:"Japan"}}},{id:"425354",title:"Dr.",name:"Marcus",middleName:"Fraga",surname:"Vieira",fullName:"Marcus Vieira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003BJSgIQAX/Profile_Picture_1627904687309",institutionString:null,institution:{name:"Universidade Federal de Goiás",institutionURL:null,country:{name:"Brazil"}}},{id:"196746",title:"Dr.",name:"Ramana",middleName:null,surname:"Vinjamuri",fullName:"Ramana Vinjamuri",profilePictureURL:"https://mts.intechopen.com/storage/users/196746/images/system/196746.jpeg",institutionString:"University of Maryland, Baltimore County",institution:{name:"University of Maryland, Baltimore County",institutionURL:null,country:{name:"United States of America"}}}]},{id:"9",title:"Biotechnology - Biosensors, Biomaterials and Tissue Engineering",keywords:"Biotechnology, Biosensors, Biomaterials, Tissue Engineering",scope:"The Biotechnology - Biosensors, Biomaterials and Tissue Engineering topic within the Biomedical Engineering Series aims to rapidly publish contributions on all aspects of biotechnology, biosensors, biomaterial and tissue engineering. We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics can include but are not limited to: Biotechnology such as biotechnological products and process engineering; Biotechnologically relevant enzymes and proteins; Bioenergy and biofuels; Applied genetics and molecular biotechnology; Genomics, transcriptomics, proteomics; Applied microbial and cell physiology; Environmental biotechnology; Methods and protocols. Moreover, topics in biosensor technology, like sensors that incorporate enzymes, antibodies, nucleic acids, whole cells, tissues and organelles, and other biological or biologically inspired components will be considered, and topics exploring transducers, including those based on electrochemical and optical piezoelectric, thermal, magnetic, and micromechanical elements. Chapters exploring biomaterial approaches such as polymer synthesis and characterization, drug and gene vector design, biocompatibility, immunology and toxicology, and self-assembly at the nanoscale, are welcome. Finally, the tissue engineering subcategory will support topics such as the fundamentals of stem cells and progenitor cells and their proliferation, differentiation, bioreactors for three-dimensional culture and studies of phenotypic changes, stem and progenitor cells, both short and long term, ex vivo and in vivo implantation both in preclinical models and also in clinical trials.",annualVolume:11405,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/9.jpg",editor:{id:"126286",title:"Dr.",name:"Luis",middleName:"Jesús",surname:"Villarreal-Gómez",fullName:"Luis Villarreal-Gómez",profilePictureURL:"https://mts.intechopen.com/storage/users/126286/images/system/126286.jpg",institutionString:null,institution:{name:"Autonomous University of Baja California",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"35539",title:"Dr.",name:"Cecilia",middleName:null,surname:"Cristea",fullName:"Cecilia Cristea",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYQ65QAG/Profile_Picture_1621007741527",institutionString:null,institution:{name:"Iuliu Hațieganu University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"40735",title:"Dr.",name:"Gil",middleName:"Alberto Batista",surname:"Gonçalves",fullName:"Gil Gonçalves",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYRLGQA4/Profile_Picture_1628492612759",institutionString:null,institution:{name:"University of Aveiro",institutionURL:null,country:{name:"Portugal"}}},{id:"211725",title:"Associate Prof.",name:"Johann F.",middleName:null,surname:"Osma",fullName:"Johann F. Osma",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSDv7QAG/Profile_Picture_1626602531691",institutionString:null,institution:{name:"Universidad de Los Andes",institutionURL:null,country:{name:"Colombia"}}},{id:"69697",title:"Dr.",name:"Mani T.",middleName:null,surname:"Valarmathi",fullName:"Mani T. Valarmathi",profilePictureURL:"https://mts.intechopen.com/storage/users/69697/images/system/69697.jpg",institutionString:"Religen Inc. | A Life Science Company, United States of America",institution:null},{id:"205081",title:"Dr.",name:"Marco",middleName:"Vinícius",surname:"Chaud",fullName:"Marco Chaud",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSDGeQAO/Profile_Picture_1622624307737",institutionString:null,institution:{name:"Universidade de Sorocaba",institutionURL:null,country:{name:"Brazil"}}}]}]}},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"profile.detail",path:"/profiles/62661",hash:"",query:{},params:{id:"62661"},fullPath:"/profiles/62661",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()