Comparison of the different drinking water standards.
\\n\\n
IntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\\n\\nBy listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
\\n\\nAll three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\\n\\n"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\\n\\n"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\\n\\nIn conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\\n\\n“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\\n\\nWe invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\\n\\nFeel free to share this news on social media and help us mark this memorable moment!
\\n\\n\\n"}]',published:!0,mainMedia:{caption:"",originalUrl:"/media/original/237"}},components:[{type:"htmlEditorComponent",content:'
After years of being acknowledged as the world's leading publisher of Open Access books, today, we are proud to announce we’ve successfully launched a portfolio of Open Science journals covering rapidly expanding areas of interdisciplinary research.
\n\n\n\nIntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\n\nBy listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
\n\nAll three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\n\n"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\n\n"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\n\nIn conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\n\n“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\n\nWe invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\n\nFeel free to share this news on social media and help us mark this memorable moment!
\n\n\n'}],latestNews:[{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"},{slug:"intechopen-identified-as-one-of-the-most-significant-contributor-to-oa-book-growth-in-doab-20210809",title:"IntechOpen Identified as One of the Most Significant Contributors to OA Book Growth in DOAB"}]},book:{item:{type:"book",id:"6144",leadTitle:null,fullTitle:"High-Resolution Neuroimaging - Basic Physical Principles and Clinical Applications",title:"High-Resolution Neuroimaging",subtitle:"Basic Physical Principles and Clinical Applications",reviewType:"peer-reviewed",abstract:"Dr. Ahmet Mesrur Halefoğlu mostly deals with research fields in body imaging and neuroradiology with multidetector computed tomography and high-resolution magnetic resonance imaging. He has served as postdoctoral research fellow at Johns Hopkins Hospital. Currently, he is working as an associate professor of radiology in Istanbul, Turkey. He has more than 50 high-impact-factor publications and has written 3 book chapters. He is a member of Turkish Society of Radiology and European Society of Radiology. During the recent years, there have been major breakthroughs in MRI due to developments in scanner technology and pulse sequencing. These important achievements have led to remarkable improvements in neuroimaging and advanced techniques, including diffusion imaging, diffusion tensor imaging, perfusion imaging, magnetic resonance spectroscopy, and functional MRI. These advanced neuroimaging techniques have enabled us to achieve invaluable insights into tissue microstructure, microvasculature, metabolism, and brain connectivity.",isbn:"978-953-51-3866-2",printIsbn:"978-953-51-3865-5",pdfIsbn:"978-953-51-4045-0",doi:"10.5772/intechopen.68268",price:119,priceEur:129,priceUsd:155,slug:"high-resolution-neuroimaging-basic-physical-principles-and-clinical-applications",numberOfPages:174,isOpenForSubmission:!1,isInWos:1,isInBkci:!1,hash:"505b513060f90e61167b5e46e8cd9fea",bookSignature:"Ahmet Mesrur Halefoğlu",publishedDate:"March 14th 2018",coverURL:"https://cdn.intechopen.com/books/images_new/6144.jpg",numberOfDownloads:14800,numberOfWosCitations:38,numberOfCrossrefCitations:33,numberOfCrossrefCitationsByBook:2,numberOfDimensionsCitations:57,numberOfDimensionsCitationsByBook:3,hasAltmetrics:1,numberOfTotalCitations:128,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"June 6th 2017",dateEndSecondStepPublish:"June 27th 2017",dateEndThirdStepPublish:"September 23rd 2017",dateEndFourthStepPublish:"December 22nd 2017",dateEndFifthStepPublish:"February 20th 2018",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"51736",title:"Prof.",name:"Ahmet Mesrur",middleName:null,surname:"Halefoğlu",slug:"ahmet-mesrur-halefoglu",fullName:"Ahmet Mesrur Halefoğlu",profilePictureURL:"https://mts.intechopen.com/storage/users/51736/images/system/51736.jfif",biography:"Dr. Ahmet Mesrur Halefoğlu is currently working as a resident specialist of Radiology and a Professor at Sisli Etfal Training and Research Hospital, Istanbul, Turkey. He has completed Antakya High School at Antakya, Hatay, Turkey, with an honors degree and has graduated from Istanbul University Cerrahpaşa Faculty of Medicine in 1986, \nIstanbul, Turkey. He completed his residency between 1992 and 1997 at Sisli Etfal Training and Research Hospital, Istanbul, Turkey. \nHe has served as a postdoctoral research fellowship at Johns Hopkins Hospital, Baltimore, MD, USA, between 1998 and 1999. \nHe has also been a research observer at Johns Hopkins Hospital in the years 2002 and 2004. \nHe is mostly dealing with research fields in body imaging and neuroradiology with multidetector computed tomography and high-resolution magnetic resonance imaging. \nHe has more than 60 high impact factor publications and has written 3 book chapters. \nHe is a member of the Turkish Society of Radiology and the European Society of Radiology.",institutionString:"Şişli Etfal Eğitim ve Araştırma Hastanesi",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"2",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"209",title:"Cognitive Neuroscience",slug:"cognitive-neuroscience"}],chapters:[{id:"57669",title:"fNIRS-Based Clinical Assessment of ADHD Children",doi:"10.5772/intechopen.71835",slug:"fnirs-based-clinical-assessment-of-adhd-children",totalDownloads:1362,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"While a growing body of neurocognitive research has explored the neural substrates associated with attention deficit hyperactive disorder (ADHD), an objective biomarker for diagnosis has not been established. The advent of functional near-infrared spectroscopy (fNIRS), which is a noninvasive and unrestrictive method of functional neuroimaging, raised the possibility of introducing functional neuroimaging diagnosis for young ADHD children. In search of a stable and clinically applicable biological marker, here in this chapter, we first discuss a plausible solution to enable the objective monitoring of the acute effects of ADHD medications at the group level. Subsequently, we discuss our successful visualization of differential neural substrates between ADHD and healthy control children for inhibitory control at the individual level, which reached an optimized classification parameter with a value of 85% and a sensitivity of 90%. These findings led us to postulate that fNIRS-based examination would allow the identification of an objective neuro-functional biomarker to diagnose and determine the appropriate treatment for ADHD children. We believe that such a novel technical application would evoke wide interest from neuroimaging researchers.",signatures:"Yukifumi Monden, Masako Nagashima, Haruka Dan, Takahiro\nIkeda, Yasushi Kyutoku, Takanori Yamagata and Ippeita Dan",downloadPdfUrl:"/chapter/pdf-download/57669",previewPdfUrl:"/chapter/pdf-preview/57669",authors:[{id:"61412",title:"Dr.",name:"Haruka",surname:"Dan",slug:"haruka-dan",fullName:"Haruka Dan"},{id:"211691",title:"Dr.",name:"Yukifumi",surname:"Monden",slug:"yukifumi-monden",fullName:"Yukifumi Monden"},{id:"224103",title:"Prof.",name:"Ippeita",surname:"Dan",slug:"ippeita-dan",fullName:"Ippeita Dan"},{id:"224105",title:"Dr.",name:"Masako",surname:"Nagashima",slug:"masako-nagashima",fullName:"Masako Nagashima"},{id:"224107",title:"Dr.",name:"Takahiro",surname:"Ikeda",slug:"takahiro-ikeda",fullName:"Takahiro Ikeda"},{id:"224109",title:"Prof.",name:"Takanori",surname:"Yamagata",slug:"takanori-yamagata",fullName:"Takanori Yamagata"},{id:"224111",title:"Mr.",name:"Yasushi",surname:"Kyutoku",slug:"yasushi-kyutoku",fullName:"Yasushi Kyutoku"}],corrections:null},{id:"57855",title:"The Role of the Magnetic Resonance Imaging for the Accurate Management of Focal Therapy with High-Intensity Focused Ultrasound for the Localized Prostate Cancer",doi:"10.5772/intechopen.71996",slug:"the-role-of-the-magnetic-resonance-imaging-for-the-accurate-management-of-focal-therapy-with-high-in",totalDownloads:1150,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"The concept of the currently attracted focal therapy is to treat clinical significant cancer with minimal invasion of health-related functions such as urethra, sphincter, neurovascular bundle, and bladder neck. The patients' criteria have been decided with pathologic tumor features characterized according to a combination of cancer core length and Gleason grade with prostate biopsy. Because the area involved in a single treatment using high-intensity focused ultrasound (HIFU) is extremely small, only minor temperature changes are observed outside of the focal zone. HIFU has been considered as an attractive therapeutic modality for the focal treatment of the prostate with the aim of curing the cancer while preserving continence and erectile function. Clinical trials of focal ablation of prostate cancer with HIFU have been reported. In our protocol, magnetic resonance imaging (MRI) has played a major role in the diagnosis of the spatial location of the significant cancer, treatment planning, and the evaluation of the treatment efficacy and recurrence after the treatment. In the chapter in “MR Imaging,” we want to present the role of MRI in the accurate management of focal therapy with HIFU for the localized prostate cancer.",signatures:"Sunao Shoji and Akira Miyajima",downloadPdfUrl:"/chapter/pdf-download/57855",previewPdfUrl:"/chapter/pdf-preview/57855",authors:[{id:"63316",title:"Dr.",name:"Sunao",surname:"Shoji",slug:"sunao-shoji",fullName:"Sunao Shoji"}],corrections:null},{id:"58247",title:"3D Polarized Light Imaging Portrayed: Visualization of Fiber Architecture Derived from 3D-PLI",doi:"10.5772/intechopen.72532",slug:"3d-polarized-light-imaging-portrayed-visualization-of-fiber-architecture-derived-from-3d-pli",totalDownloads:1395,totalCrossrefCites:1,totalDimensionsCites:6,hasAltmetrics:1,abstract:"3D polarized light imaging (3D-PLI) is a neuroimaging technique that has recently opened up new avenues to study the complex architecture of nerve fibers in postmortem brains at microscopic scales. In a specific voxel-based analysis, each voxel is assigned a single 3D fiber orientation vector. This leads to comprehensive 3D vector fields. In order to inspect and analyze such high-resolution fiber orientation vector field, also in combination with complementary microscopy measurements, appropriate visualization techniques are essential to overcome several challenges, such as the massive data sizes, the large amount of both unique and redundant information at different scales, or the occlusion issues of inner structures by outer layers. Here, we introduce a comprehensive software tool that is able to visualize all information of a typical 3D-PLI dataset in an adequate and sophisticated manner. This includes the visualization of (i) anatomic structural and fiber architectonic data in one representation, (ii) a large-scale fiber orientation vector field, and (iii) a clustered version of the field. Alignment of a 3D-PLI dataset to an appropriate brain atlas provides expert-based delineation, segmentation, and, ultimately, visualization of selected anatomical structures. By means of these techniques, a detailed analysis of the complex fiber architecture in 3D is feasible.",signatures:"Nicole Schubert, Markus Axer, Uwe Pietrzyk and Katrin Amunts",downloadPdfUrl:"/chapter/pdf-download/58247",previewPdfUrl:"/chapter/pdf-preview/58247",authors:[{id:"164075",title:"Dr.",name:"Markus",surname:"Axer",slug:"markus-axer",fullName:"Markus Axer"},{id:"211977",title:"M.Sc.",name:"Nicole",surname:"Schubert",slug:"nicole-schubert",fullName:"Nicole Schubert"},{id:"232971",title:"Prof.",name:"Uwe",surname:"Pietrzyk",slug:"uwe-pietrzyk",fullName:"Uwe Pietrzyk"},{id:"232972",title:"Prof.",name:"Katrin",surname:"Amunts",slug:"katrin-amunts",fullName:"Katrin Amunts"}],corrections:null},{id:"59087",title:"Detection of Brain Tumor in MRI Image through Fuzzy-Based Approach",doi:"10.5772/intechopen.71485",slug:"detection-of-brain-tumor-in-mri-image-through-fuzzy-based-approach",totalDownloads:1489,totalCrossrefCites:5,totalDimensionsCites:6,hasAltmetrics:0,abstract:"The process of accurate detection of edges of MRI images of a brain is always a challenging but interesting problem. Accurate detection is very important and critical for the generation of correct diagnosis. The major problem that comes across while analyzing MRI images of a brain is inaccurate data. The process of segmentation of brain MRI image involves the problem of searching anatomical regions of interest, which can help radiologists to extract shapes, appearance, and other structural features for diagnosis of diseases or treatment evaluation. The brain image segmentation is composed of many stages. During the last few years, preprocessing algorithms, techniques, and operators have emerged as a powerful tool for efficient extraction of regions of interest, performing basic algebraic operations on images, enhancing specific image features, and reducing data on both resolution and brightness. Edge detection is one of the techniques of image segmentation. Here from image segmentation, tumor is located. Finally, we try to retrieve tumor from MRI image of a brain in the form of edge more accurately and efficiently, by enhancing the performance of diffe rent kinds of edge detectors using fuzzy approach.",signatures:"Neha Mathur, Yogesh Kumar Meena, Shruti Mathur and Divya\nMathur",downloadPdfUrl:"/chapter/pdf-download/59087",previewPdfUrl:"/chapter/pdf-preview/59087",authors:[{id:"213292",title:"Associate Prof.",name:"Neha",surname:"Mathur",slug:"neha-mathur",fullName:"Neha Mathur"},{id:"214822",title:"Mrs.",name:"Shruti",surname:"Mathur",slug:"shruti-mathur",fullName:"Shruti Mathur"},{id:"214823",title:"Mrs.",name:"Divya",surname:"Mathur",slug:"divya-mathur",fullName:"Divya Mathur"},{id:"223291",title:"Dr.",name:"Dr. Yogesh Kumar",surname:"Meena",slug:"dr.-yogesh-kumar-meena",fullName:"Dr. Yogesh Kumar Meena"}],corrections:null},{id:"57470",title:"MRI RF-Induced Heating in Heterogeneous Human Body with Implantable Medical Device",doi:"10.5772/intechopen.71384",slug:"mri-rf-induced-heating-in-heterogeneous-human-body-with-implantable-medical-device",totalDownloads:1701,totalCrossrefCites:3,totalDimensionsCites:4,hasAltmetrics:0,abstract:"Magnetic resonance imaging (MRI) radio frequency (RF)-induced heating is one of the most important concerns of MRI safety for patients, especially with orthopaedic healthcare products. In this chapter, numerical modelling and simulations were conducted to study the RF-induced heating within a 1.5T and 3T magnetic resonance (MR) environment. Numerical simulations were firstly conducted to study the difference between the cases of implantable medical devices inside the phantom and the human body. Then, numerical modelling were conducted to describe the difference of electromagnetic behaviours between the homogeneous phantom and heterogeneous human tissues. The MRI RF-induced heating due to an implantable medical device behaves significantly different in homogeneous media and in heterogeneous human body. For typical orthopaedic medical devices, such as healthcare products applied to shoulder, humerus, hip, femur and tibia, the properties of the RF-induced heating are different in general phantom and in human body. The hot spot location, as well as worst case configuration were evaluated and it was found that they were determined by the incident field and electromagnetic properties of medium. With further scaling, the RF-induced heating in human body for the orthopedic devices can be assessed by phantom studies.",signatures:"Ran Guo, Jianfeng Zheng and Ji Chen",downloadPdfUrl:"/chapter/pdf-download/57470",previewPdfUrl:"/chapter/pdf-preview/57470",authors:[{id:"213555",title:"Ph.D.",name:"Jianfeng",surname:"Zheng",slug:"jianfeng-zheng",fullName:"Jianfeng Zheng"},{id:"213557",title:"BSc.",name:"Ran",surname:"Guo",slug:"ran-guo",fullName:"Ran Guo"}],corrections:null},{id:"58837",title:"Advanced Brain Tumour Segmentation from MRI Images",doi:"10.5772/intechopen.71416",slug:"advanced-brain-tumour-segmentation-from-mri-images",totalDownloads:2206,totalCrossrefCites:5,totalDimensionsCites:8,hasAltmetrics:0,abstract:"Magnetic resonance imaging (MRI) is widely used medical technology for diagnosis of various tissue abnormalities, detection of tumors. The active development in the computerized medical image segmentation has played a vital role in scientific research. This helps the doctors to take necessary treatment in an easy manner with fast decision making. Brain tumor segmentation is a hot point in the research field of Information technology with biomedical engineering. The brain tumor segmentation is motivated by assessing tumor growth, treatment responses, computer-based surgery, treatment of radiation therapy, and developing tumor growth models. Therefore, computer-aided diagnostic system is meaningful in medical treatments to reducing the workload of doctors and giving the accurate results. This chapter explains the causes, awareness of brain tumor segmentation and its classification, MRI scanning process and its operation, brain tumor classifications, and different segmentation methodologies.",signatures:"Kavitha Angamuthu Rajasekaran and Chellamuthu Chinna\nGounder",downloadPdfUrl:"/chapter/pdf-download/58837",previewPdfUrl:"/chapter/pdf-preview/58837",authors:[{id:"213441",title:"Dr.",name:"A.R.Kavitha",surname:"Balaji",slug:"a.r.kavitha-balaji",fullName:"A.R.Kavitha Balaji"},{id:"222721",title:"Dr.",name:"Chellamuthu",surname:"Chinna Gounder",slug:"chellamuthu-chinna-gounder",fullName:"Chellamuthu Chinna Gounder"}],corrections:null},{id:"58070",title:"MRI Medical Image Denoising by Fundamental Filters",doi:"10.5772/intechopen.72427",slug:"mri-medical-image-denoising-by-fundamental-filters",totalDownloads:2553,totalCrossrefCites:17,totalDimensionsCites:30,hasAltmetrics:1,abstract:"Nowadays Medical imaging technique Magnetic Resonance Imaging (MRI) plays an important role in medical setting to form high standard images contained in the human brain. MRI is commonly used once treating brain, prostate cancers, ankle and foot. The Magnetic Resonance Imaging (MRI) images are usually liable to suffer from noises such as Gaussian noise, salt and pepper noise and speckle noise. So getting of brain image with accuracy is very extremely task. An accurate brain image is very necessary for further diagnosis process. During this chapter, a median filter algorithm will be modified. Gaussian noise and Salt and pepper noise will be added to MRI image. A proposed Median filter (MF), Adaptive Median filter (AMF) and Adaptive Wiener filter (AWF) will be implemented. The filters will be used to remove the additive noises present in the MRI images. The noise density will be added gradually to MRI image to compare performance of the filters evaluation. The performance of these filters will be compared exploitation the applied mathematics parameter Peak Signal-to-Noise Ratio (PSNR).",signatures:"Hanafy M. Ali",downloadPdfUrl:"/chapter/pdf-download/58070",previewPdfUrl:"/chapter/pdf-preview/58070",authors:[{id:"213318",title:"Dr.",name:"Hanafy",surname:"Ali",slug:"hanafy-ali",fullName:"Hanafy Ali"}],corrections:null},{id:"59370",title:"Fourier Velocity Encoded MRI: Acceleration and Velocity Map Estimation",doi:"10.5772/intechopen.72531",slug:"fourier-velocity-encoded-mri-acceleration-and-velocity-map-estimation",totalDownloads:983,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Fourier velocity encoding (FVE) is an alternative to phase contrast imaging (PC). FVE provides considerably higher SNR than PC, due to its higher dimensionality and larger voxel sizes. Furthermore, FVE is robust to partial voluming, as it resolves the velocity distribution within each voxel. FVE data are usually acquired with low spatial resolution, due to scan-time restrictions associated with its higher dimensionality. FVE is capable of providing the velocity distribution associated with a large voxel, but does not directly provides a velocity map. Knowing the velocity distribution on a voxel is important for accurate diagnosis of stenosis in vessels on the scale of spatial resolution. Velocity maps, however, are useful for visualizing the actual blood flow through a vessel and can be used in different studies and diagnosis. In this context, this chapter deals with two aspects of the FVE MRI technique: acceleration and estimation of velocity map. First, are introduced six different acceleration techniques that can be applied to FVE acquisition. Methods such as variable-density sampling and compressive sampling. Then, is proposed a novel method to estimate velocity maps with high spatial resolution from low-resolution FVE data. Finally, it can be concluded that FVE datasets can be acquired in time scale comparable to PC, it contains more velocity information, since it resolves a velocity distribution within a voxel, and also provides an accurate estimation of the velocity map.",signatures:"Vinicius C. Rispoli, Joao L.A. Carvalho, Cristiano J. Miosso and\nFabiano A. Soares",downloadPdfUrl:"/chapter/pdf-download/59370",previewPdfUrl:"/chapter/pdf-preview/59370",authors:[{id:"36213",title:"Prof.",name:"Joao",surname:"Carvalho",slug:"joao-carvalho",fullName:"Joao Carvalho"},{id:"208686",title:"Dr.",name:"Vinicius",surname:"Rispoli",slug:"vinicius-rispoli",fullName:"Vinicius Rispoli"},{id:"209663",title:"Dr.",name:"Cristiano",surname:"Miosso",slug:"cristiano-miosso",fullName:"Cristiano Miosso"},{id:"216170",title:"Dr.",name:"Fabiano",surname:"Soares",slug:"fabiano-soares",fullName:"Fabiano Soares"}],corrections:null},{id:"57618",title:"Basics of Chemical Exchange Saturation Transfer (CEST) Magnetic Resonance Imaging",doi:"10.5772/intechopen.71645",slug:"basics-of-chemical-exchange-saturation-transfer-cest-magnetic-resonance-imaging",totalDownloads:1961,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Chemical exchange saturation transfer (CEST) is one of the contrast mechanisms in magnetic resonance imaging (MRI) and has been used to detect dilute proteins through the interaction between bulk water and labile solute protons. Amide proton transfer (APT) MRI has been developed for imaging diseases such as acute stroke. Moreover, various CEST agents have been explored to enhance the CEST effect. The contrast mechanism of CEST or APT MRI, however, is complex and depends not only on the concentration of amide protons or CEST agents and exchange properties, but also varies with imaging parameters such as radiofrequency (RF) power and magnetic field strength. When there are multiple exchangeable pools within a single CEST system, the contrast mechanism of CEST becomes even more complex. Numerical simulations are useful and effective for analyzing the complex contrast mechanism of CEST and for investigating the optimal imaging parameter values. In this chapter, we present the basics of CEST or APT MRI and a simple and fast numerical method for solving the time-dependent Bloch-McConnell equations for analyzing the behavior of magnetization and/or contrast mechanism in CEST or APT MRI. We also present a method for analyzing the behavior of magnetization in spin-locking CEST MRI.",signatures:"Kenya Murase",downloadPdfUrl:"/chapter/pdf-download/57618",previewPdfUrl:"/chapter/pdf-preview/57618",authors:[{id:"213859",title:"Prof.",name:"Kenya",surname:"Murase",slug:"kenya-murase",fullName:"Kenya Murase"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"6005",title:"Computed Tomography",subtitle:"Advanced Applications",isOpenForSubmission:!1,hash:"8a17c8499e693346539688f5d170a43d",slug:"computed-tomography-advanced-applications",bookSignature:"Ahmet Mesrur Halefoglu",coverURL:"https://cdn.intechopen.com/books/images_new/6005.jpg",editedByType:"Edited by",editors:[{id:"51736",title:"Prof.",name:"Ahmet Mesrur",surname:"Halefoğlu",slug:"ahmet-mesrur-halefoglu",fullName:"Ahmet Mesrur 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\r\n\tOrganic electronics can impact healthcare, sports, and national security through inventions such as real-time biosensing and drug-delivery, stretchable and flexible sport track gear, and the electronic- nose and tongue. Organic semiconductors, based on carbon and hydrogen, two of the most abundant and low cost materials, can transduce ionic and electronic carriers into quantifiable data paving the way for multi-functional applications that are not easy to create with other material systems and often go beyond the working principle of the conventional field-effect transistor. We will begin our review with a general overview of the current state of OFETs focusing on complex architectures, materials and fabrication processes. We will discuss the device physics and explain the doping mechanisms that can exist in organic semiconducting channel materials. Then we will focus on exciting applications that include the electronic- nose and tongue, myriad biosensing applications for preventive, point-of-care testing and real-time drug delivery, emerging physico-chemical low cost sensing applications, and the well known flexible, stretchable electronics.
",isbn:null,printIsbn:"979-953-307-X-X",pdfIsbn:null,doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!1,isSalesforceBook:!1,hash:"787c5b02acbbf3f4efda634be5e6f3c0",bookSignature:"Dr. Jonathan Sayago",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/7741.jpg",keywords:"double-gate, floating-gate, abundant materials, charge carrier mobilities, electronic nose, electronic tongue, preventive health care, real-time drug delivery, radiation dosimeters, pH meter, sport track gear, wearable electronics",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:0,numberOfDimensionsCitations:0,numberOfTotalCitations:0,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"November 7th 2019",dateEndSecondStepPublish:"March 10th 2020",dateEndThirdStepPublish:"May 9th 2020",dateEndFourthStepPublish:"July 28th 2020",dateEndFifthStepPublish:"September 26th 2020",remainingDaysToSecondStep:"2 years",secondStepPassed:!0,currentStepOfPublishingProcess:5,editedByType:null,kuFlag:!1,biosketch:null,coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"198513",title:"Dr.",name:"Jonathan",middleName:null,surname:"Sayago",slug:"jonathan-sayago",fullName:"Jonathan Sayago",profilePictureURL:"https://mts.intechopen.com/storage/users/198513/images/system/198513.jpg",biography:"Jonathan Javier Sayago Hoyos is a research associate at the National Autonomous University of Mexico. During his doctoral studies, Dr. Sayago tackled the problem of achieving low-voltage organic transistors employing electrolytes as the gating medium. His research contributed to shedding light on fundamental physicochemical processes in electrochemical transistors and energy storage devices. After his PhD studies, Dr. Sayago worked as a consultant for Bowhead Health Inc., a Canadian startup company aiming for the commercialization of bioelectronic devices for preventive medical applications. His team designed and built a biosensor device capable of testing 50 µl of blood which led the company to secure a private funding from the world-class Mexican company Grupo Arcoiris. As a Postdoctoral Researcher at the Institute of Renewable Energies, UNAM, Dr. Sayago investigates biocompatible and biodegradable electrodes engineered for energy storage and heat transfer applications. Derived from this work he authored and co-authored over 10 articles in highly recognized international journals, 3 book chapters and participated in numerous international conferences and workshops. Dr. Sayago has taught courses in mathematics, advanced physics laboratory, computer assisted design and 3D printing, and tutoring sessions. 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The available freshwater resource is only 2.7% of the available water on earth but only 1% of the available freshwater (in lakes, rivers and groundwater) is accessible. Most of the available freshwater resources are inaccessible because they are in the hidden part of the hydrologic cycles (deep aquifers) and in glaciers (frozen in the polar ice), which means safe drinkable water on earth has very small proportion (~3%) in the freshwater resources. Freshwater can also be obtained from the seawater by desalinization process. In some countries, sufficient freshwater is not available (
South Africa receives about 450 mm annual rainfall and is classified as a water-stressed country [1, 2]. The available freshwater resource can sustain 80 million people only. Some African countries (Ethiopia, Congo and Papua New Guinea) have excess freshwater resources, but they are having water shortage due to economic reasons. Ethiopia, the second populous countries in Africa, is the water tower of east Africa due to the availability of abundant water (nine major river basins). However, the country is among the few countries in the world affected by chronic water problem. The water scarcity in the world is further aggravated by the reduced water quantity (or an increased water demands) due to population growth and the declining of water quality by pollution.
As a criterion, an adequate, clean and safe drinking water supply has to be available for various users [3]. There is no universally accepted definition of “safe drinking water.” Safe drinking water is defined as the water that does not represent any significant risk to health over a lifetime of consumption [4]. The safe drinking water must be delivered that is pure, wholesome, healthful and potable. Safe water is not necessarily pure, it has some impurities in it. It contains some traces of salts such as magnesium, calcium, carbonates, bicarbonates and others. The degree of purity and safety is a relative term and debatable. Clean/pure water has no minerals and it only contains H and O. According to the Monitoring organizations under the supervision of the Joint Monitoring Programme (JMP), “safe drinking water” is defined as water from an “improved water source,” which includes household connections, public standpipes, boreholes, protected dug wells, protected springs and rainwater collections. According to the same organization, “access to safe drinking water” is defined as the availability of at least 20 l per person per day from an “improved” source within 1 km of the user’s dwelling.
Safe drinking (potable) water is the water that can be delivered to the user and is safe for drinking, food preparation, personal hygiene and washing [3]. The water must meet the required (chemical, biological and physical) quality standards at the point of supply to the users [5]. Therefore, safe drinking water is a relative term, which depends on the standards and guidelines of a country; the standards set for the different quality parameters are different. The standard of WHO is not exactly the same as that of USA, Canada, European Commission, Russia, India, South Africa, Ethiopia, and so on. The term “safe” depends on the particular resistance ability of an individual. Water that is safe for drinking in some African countries might not be safe in European countries. Some African countries already developed resistance to some of the water-related diseases.
Safe drinking water is anonymously accepted as an international agenda and priority, which is evident from the MDGs and SDGs of the United Nations (UN) initiative and vision (MDGs 7 and SDGs 6). Despite the MDGs effort, still many people lack access to safe drinking water, even lack access to basic water. Globally, more than 1 billion people do not have access to safe drinking water. According to the Third World Academy of Sciences (TWAS) report [6], contaminated/dirty water is killing more people than cancer, AIDS, wars or accidents. Population of the world is increasing and the available freshwater resources almost remain constant. The number of people without access to safe drinking water is increasing. This is mostly related to the ever-increasing population growth in the developing countries and the inability (or unwillingness) of governments (local and national) to provide adequate water supply facilities in these countries [7].
Water is connected to every form of life on earth and is the basic human need, equally important as air. Water is connected to every aspect of human day-to-day activities directly or indirectly. At a basic level, everyone needs access to safe water in adequate quantities for drinking, cooking, personal hygiene and sanitation facilities that do not compromise health or dignity. Therefore, access to safe and dependable (clean and fresh) water is the fundamental/basic right of humans [8]. The UN and other countries declared that access to clean, safe drinking water is a basic human right, and an essential step toward improving living standards worldwide. Access to water was one of the main goals of UN-MDGs and it is also one of the main goals of the UN-SDGs. The South African constitution declares “
Globally, it is estimated that 89% of people have access to water suitable for drinking [10]. According to UNDP [11] report, one out of six people do not have access to clean water, that is, about 1.1 billion people lack access to safe drinking water. In some countries, especially in Africa, almost half of the population do not have access to safe drinking water and hence, is afflicted with poor health [12]. The number of people without safe drinking water is more than the number reported by UNDP [11]. This is due to the fact that most of the water supply facilities initiated during the MDGs in developing countries are not functioning properly.
Water of satisfactory quality is the fundamental indicator of health and well-being of a society and hence, crucial for the development of a country. Contaminated water not only has the potential to pose immediate threat to human, but also can affect an individual productive rate [13]. According to the WHO [14] report, an estimated 1.1 billion people in the world drink unsafe water. Approximately 3.1% of the global annual death (1.7 million) and 3.7% of the annual burden (disability) (54.2 million) are caused by the use of unsafe water and lack of basic sanitation and hygiene.
Water provides a number of benefits and services for humans and the ecosystem. As reported by OECD [15], the benefit of water is not documented sufficiently, resulting in low political priority for water issues and in suboptimal levels of investment in water infrastructures. The same document also indicates that the benefit of water is mostly hidden in other technical documents. Most researchers have indicated that the benefit-cost ratio of access to water is more than 2, and in some cases, it can reach 7.0. In developing countries like Africa, the benefit-cost ratio of access to water is very high (more than 5:1 ratio) because it is related to every dimension of developmental activities (agriculture, energy, industry, etc.). In such areas, the return on investment in water services usually result in a substantial economic gains, estimated in the range of 5–28 USD per 1 USD [7]. In addition to the economic gains, water supply projects have technical, environmental and political gains. Water sector is interconnected with other development sectors (agriculture, energy, industry, etc.) and factors (social, economic, environmental, health, educational, legal and political) at local, national levels, regional and international levels [16]. In fact, access to safe water has a number of direct and indirect benefits related to health, education, poverty and environment. The UN World Water Development Report [7] indicated that there is a linkage or nexus between water and sustainable development, far beyond its social, economic and environmental dimensions. The report clearly indicated that access to safe water has a great role in addressing the developmental challenges, such as human health, food and energy security, urbanization and industrial growth, as well as climate changes. Especially, there is a strong nexus between water, food and energy [3].
The MDGs of the UN targeted to “
Research has shown that the majority of people without access to safe water are from developing nations [18]. This shows that many people in the developing world, especially Africa, still depend on unsafe water sources for daily water need and affected by chronic water problems and water-borne diseases. Millions of people die due to water-related diseases like cholera, diarrhea, malaria, dengue fever, and so on. Globally, water-borne diseases kill more than 25,000 people per day and about 5000 children die per day due to water-related diseases (mainly diarrhea) [12], most of them can be easily prevented. Diarrhea and related diseases kill about 1.8 million children every year, most of them are in developing countries [19]. It is also estimated that about 1.8 billion people drink water contaminated with
In cognizant to the benefits of water, the newly introduced ambitious Sustainable Development Goal (SDG) by UN in 2014 [21] considers water as one of the main developmental pillars under SDG 6. In fact, water was also one of the main goals of the UN-MDGs. The UN-SDG 6 states that “
There are basic standards, norms, criterion and indicators for safe drinking water. There are also policies, strategy and program under safe drinking water. These terms are well defined by Bos et al. [3]. Norm refers to the standard of development related to the large group of society. Criterion refers to the agreed norm or standard used for the decision. Indicator refers to the measured value of individual water quality parameters. Standard refers to the agreed target/threshold value established as an agreed target, which is set by an authority. There are various water quality standards and criteria in the world. Details of the water quality standards are provided under Section 5.3.
Water regulations are important for the provision of drinking water that is sufficient in quantity, safe, accessible, acceptable, affordable and reliable. Drinking water regulations include controlling of the water supply systems which are water source, water treatment, distribution, use, wastewater and gray water. Countries regulate drinking water differently depending on the quality of their water source. As stated earlier, different countries regulate drinking water differently depending on the quality of their water source.
In South Africa, water sources are monitored by the Department of Water and Sanitation (DWS). This was achieved by the implementation of the National Water Act (NWA) 36 of 1998 [9]. The purpose of the NWA is to ensure that the nation’s water resources are protected, used, developed, conserved, managed and controlled. Local authorities are responsible for the supply of water to residents. This was achieved by the implementation of the Water Services Act (WSA) 108 of 1997. WSA are established to provide the following services [9]: (1) ensuring the rights of access to basic water supply and sanitation; (2) setting national standards, norms and tariffs; (3) water service development plans; (4) prepare the regulatory framework for water service institutions and intermediaries; (5) establish and disestablish committee for water boards and water services and their powers and duties; (6) monitoring water services and intervention and (7) providing financial assistance to water service institutions.
As a criterion, an adequate, clean and safe drinking water supply has to be available for various users [3]. Moreover, water has to be accessible for all, including children, elders and disabled ones. Water
The role of a drinking water supplier is to provide adequate water for the community and prevent/mitigate risk of water contamination in different elements/points of water supply system such as source, treatment and distribution. They also should assure the delivery of a safe and esthetically pleasing drinking water to the consumer’s point. In general, the prevention, mitigation and elimination of water contamination are the responsibilities of water providers and regulators. Water regulations are also important for the provision of drinking water that is sufficient in quantity, safe, accessible, acceptable, affordable and reliable. Countries regulate drinking water differently depending on the quality of their water source. According to the WHO [23] and US Environmental Protection Agency [24], there are guidelines and principles that need to be followed for water to be considered fit for use. The guidelines are as follows: physical, microbial, chemical and radiological. The water quality standards for different countries are summarized under Section 6.1.
The water supply system (WSS) is a system of hydrologic and hydraulic components, including all buildings and installations, used to meet water requirement of industrial and population centers. It consists of capturing raw water, drainage basin, water capturing and transmission pipes, water treatment plants, treated water transfer pipes, drinking water adduction pipes, pumping stations and pumping, water storage tanks and water distribution networks to the consumers [25, 26, 27]. A conventional water supply system is a combination of complex subsystems, consisting of the water supply catchment, water storage reservoir, water treatment plant and water distribution network [26]. Water supply and distribution systems typically comprise a combination of source works, treatment facilities, service reservoirs, pumping stations, pipes, valves and so on [25].
In the ambitious vision 2050 of the SDG, sufficient and safe water has to be available for all to support human’s basic needs and ecosystem integrity [7]. The sustainable development of the world largely depends on the sustainable development of water since other sectors are interrelated with water resources. It requires the progress of the three dimensions of the sustainable development (social, economic and environmental) [7]. Thus, the vision of SDGs (goal 6) for water requires management of the available water and related resources in an integrated, inclusive and participatory approach. Huge investment is highly needed for infrastructure, treatment plant systems and water recycling [29].
A WSS may face a number of challenges associated with many factors in provision of quality, efficient, reliable, resilient and sustainable water supply for the present and future generations. Rural areas are facing more financial and technical difficulties than urban areas. According to da Silva et al. [29], wealthier urban areas have more financial capacity and technical expertise than the poor rural communities to raise the capital needed for water infrastructure. Especially in rural areas with arid environment and great hydrologic variability, reliable and dependable WSS requires energy intensive infrastructure. A study made by Chung et al. [30] showed that robust optimization approach is a useful tool in reliable WSS design, under uncertainty, that prevents system failure at a certain level of risk.
Achieving the SDG requires huge
The other challenge of sustainable water supply is the
In urban areas, the infrequent and insufficient application of
Moreover, there is an urgent need to move toward
In fast-growing urban regions,
There are a number of factors challenging WSS. Some of the factors are aging infrastructure, water service provision thinking horizons, catchment (mountain)-specific issues, climate change, knowledge gaps with respect to present and future hydrology, accurate water demand prediction, land use/cover change, optimal operation of water supply systems, cost recovery, operating cost, water quality (water pollution), water scarcity, water leaks, low water pressure, over-use, response to drought and natural disasters, rapid urbanization, population growth, migration, demographic changes, economic development, consumer behavioral patterns, efficiency and reliability of a water supply system, self-sufficiency through use of alternative water sources, dynamic and uncertain urban water systems, complex dynamic human-environment coupled systems (non-holistic or siloed management), lack of adaptive capacity indicators to assess sustainability of water systems, scant attention of smart water grids (not supported by information and communications technology), lack of policies and programs that consider rural diversity and cultural differences and neglecting wastewater management are mentioned as challenges to water supply systems for provision of sustainable and reliable water services, which meet acceptable standards for present and future generations [14, 25, 26, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49].
According to Berg and Danilenko [38], WSS has faced a number of global challenges in the twenty-first century. The major challenges are population growth, uncertain climate changes, socio-environmental issues, limited water resources, economic crises and continuous aging process. There are a number of problems associated with the continuous aging process, including low pressure, water loss and water quality deterioration [36]. The major challenges in the provision of safe water and sanitation on a global basis are [37]: (1) water contamination within distribution systems; (2) increasing water scarcity and shortages; (3) implementing innovative and low-cost sanitation systems; (4) providing sustainable water supply systems and sanitation for megacities; (5) reducing the disparities in access to water and sanitation and (6) developing financially feasible water and sanitation services.
Water is most fundamental in shaping the land and regulating the climate. It is one of the most important resources that profoundly influence life. Water quality is the most fundamental controlling factor when it comes to health and the state of diseases in both humans and animals. According to WHO report [23], about 80% of all the human diseases in human beings are caused by water.
Depending on the purpose of water quality analysis, water quality can be defined based on a set of biological, physical and chemical variable, which are closely linked to the water’s intended use. As a principle, drinking water is supposed to be free from harmful pathogens and toxic chemicals [3]. Contamination of freshwater (especially groundwater) sources is one of the main challenges currently faced by the South Africans, more especially in communities who depend almost exclusively on groundwater [52]. Groundwater is used for domestic, industrial and agricultural water supply in all four corners of the world. Therefore, the presence of contaminants in natural freshwater continues to be one of the most important environmental issues in many areas of the world, more especially in developing countries [53]. Once the groundwater is contaminated, its quality cannot be restored back easily, the best way is to protect it.
The concept and theory of water quality is very broad since it is influenced by many factors. Water quality is based on the intended uses of water for different purposes, that is, different water uses require different criteria to be satisfied. In water quality analysis, all of the accepted and unaccepted values must be clearly defined for each quality variable. If the quality variables meet the pre-established standards for a given use is considered safe for that use. When water fails to meet these standards, it must be treated if possible before use.
Physical quality parameters are related to total solids content, which is composed of floating matter, settleable matter, colloidal matter and matter in solution. The following physical parameters are determined in water [12]:
The chemical constituents have more health concerns for drinking water than for the physical constituents. The objectionability of most of the physical parameters are based on esthetic value than health effects. But the main objectionability of some of the chemical constituents is based on esthetic as well as concerns for adverse health effects. Some of the chemical constituents have an ability to cause health problems after prolonged period of time [54]. That means the chemical constituents have a cumulative effect on humans. The chemical quality parameters of water include alkalinity, biological oxygen demand (BOD), chemical oxygen demand (COD), dissolved gases, nitrogen compounds, pH, phosphorus and solids (organic). Sometimes, chemical characteristics are evidenced by their observed reactions such as in laundering, redox reactions, and so on [12, 54].
Below is a list of some of the chemical compounds and elements found in water:
Biological parameters are the basic quality parameters for the control of diseases caused by pathogenic organisms, which have human origin. Pathogenic organisms found in surface water include bacteria, fungi, algae, protozoa, plants and animals and viruses. Some of these disease-causing organisms (bacteria, fungi, algae, protozoa and viruses) are not identifiable and can only be observed microscopically. Microbiological agents are very important in their relation to public health and may also be significant in the modification of physical and chemical characteristics of water [12]. Water for drinking and cooking purposes must be free from pathogens. The greatest microbial risks are associated with consumption of water that is contaminated with human or animal feces. Feces can carry pathogenic bacteria, protozoa, helminthes and virus. Pathogens originating from feces are the principle concerns in setting health-based targets for microbial safety. Water-borne diseases are particularly to be avoided because of the capacity of result in the simultaneous infection of large number of people. While water can be a very significant source of infectious organisms, many of the diseases that may be waterborne may also be transmitted by other routes, including person-to-person contact, droplets and aerosols and food intake [54].
The techniques for comprehensive bacteriological test are complex and time consuming. Different tests have been developed to detect the relative degree of bacterial contaminations in terms of an easily defined quantity. There are two mostly used test methods widely used to estimate the number of microorganism of coliform groups (
As presented in Section 3.1, standard is defined as a basis for judging the quality. A standard for drinking water quality is thus the reference that will ensure that the delivered water will not pose any threat or harm to human health. The water quality standard is the framework against which a water sample can be considered satisfactory or safe for use [54]. There are a number of standard guidelines for drinking purposes such as World Health Organization [54], Commission for European Union [55], U.S. Environmental Protection Agent [24], Environmental Canada [56], Russian Standard [57], Indian Standard [58, 59], South African National Standard [60] and Ethiopian Standards [61]. Most developing and other developed countries use the WHO standards for drinking water [54]. Table 1 summarizes water quality guidelines of different countries.
Parameters | Standard concentrations | ||||||||
---|---|---|---|---|---|---|---|---|---|
WHOa | USA (USEPAb) | Europe (CEUc) | Russiad | Canada (ECe) | Indiaf | South Africag (SANS) | Ethiopiah (ESA) | ||
HDL | MPL | ||||||||
PH | 7.0–8.5 | 6.5–8.5 | 6.5–8.5 | 6.5–8.5 | 6.0–9.0 | 6.5–8.5 | 6.5–9.2 | 6.5–9.0 | 6.5–8.5 |
EC | 300 | 1400 | – | – | 2000 | – | – | – | |
Na+ | – | 200 | – | – | 200 | 20 | 150 | 100 | 200 |
Ca2+ | 75 | 100 | – | – | – | – | 100 | 32 | 75 |
Mg2+ | 30 | 50 | – | – | – | – | 100 | 30 | 50 |
K+ | 12 | 200 | – | – | – | – | – | 50 | 1.5 |
Cl− | 200 | 600 | 250 | 250 | 350 | 250 | 1000 | 200 | 250 |
– | 45 | – | – | – | – | – | – | – | |
– | 500 | – | – | – | – | 400 | – | – | |
TH | 200 | 500 | – | – | – | 300 | 600 | – | 300 |
F | 1.0 | 1.5 | 2.0 | 1.5 | 1.5 | 1.5 | – | 1.0 | 1.5 |
B | – | 0.3 | – | 1.0 | 0.3 | 5.0 | 5 | – | 0.3 |
200 | 250 | 250 | 250 | 500 | 250 | 400 | 200 | 250 | |
TDS | 500 | 600 | 500 | – | 1000 | 500 | 1500 | 450 | 1000 |
Comparison of the different drinking water standards.
P – probability (%); HDL – highest desirable limit; MPL – maximum permissible limit; USEPA – United States Environmental Protection Agency; CEU – Commission of European Union; EC – Environmental Canada.
Sources: aWHO [54], bUSEPA [24], cCEU [55], dUNESCO/WHO/UNEP [56], eHealth Canada [57], fISI [58] and BIS [59], gSANS [60], hESA [61]. Note that the values indicated for the different standards other than WHO are the maximum permissible limits.
It is difficult to quantify the overall suitability of water for drinking based on the various guidelines presented in Table 1. The interpretation of the various water quality parameters separately is usually a difficult task for general public as well as decision and policy makers. Therefore, the calculation of a general water quality index (WQI) is extremely important in order to communicate the quality of water in a better and understandable ways. There are different approaches of calculating WQI. In this section, a brief description has been provided for the weighted Arithmetic Water Quality Index Method proposed by Tiwari and Mishra [62] and adopted by others [63, 64, 65, 66, 67]. The quality rating (qi), the sub-index (SI) [65] and the relative weights (Wi) are calculated using Eqs. (1)–(3).
where Vi and Siare the analytical and the standard value for the ith parameter, respectively, Vo is the ideal value of the ith parameter in pure water (Vo = 0, except pH =7.0). The standard value is usually considered as the maximum permissible level set by WHO [10, 14, 54] or as per the standards for different countries presented in Table 1. Wi is the relative weights for various water quality parameters, assumed to be inversely proportional to the recommended standards for the corresponding parameters. wi is the unit weight of each parameter according to its relative importance in the overall quality of water for drinking purposes. The wi values are provided by Tiwari and Mishra [62], which depend on the number of parameters considered in the calculation of WQI. Note that the ∑Wi should be equal to 1.
Finally, the overall WQI (Eq. (4)) is calculated for each of the water sources by aggregating the quality rating (qi) linearly and taking their weighted mean.
WQI classes are as follows: 0–25 (excellent, grade A), 26–50 (good, grade B), 51–75 (poor, grade C), 76–100 (very poor, grade D), >100 (unfit for drinking, Grade E).
As water is a basic need for human life, access to clean, safe drinking water is a basic human right. As a criterion, an adequate, reliable, clean, acceptable and safe drinking water supply has to be available for various users. Moreover, everyone needs access to safe water in adequate quantities for drinking, cooking and personal hygiene and sanitation facilities that do not compromise health or dignity. Access to water is one of the most important catalysts given high priority by the UN for sustainable development. Despite these facts, there are inequalities in access to safe drinking water in the world. There are a number of factors challenging the sustainable WSS. Some of the factors are related to infrastructures (aging), clean water issues (quality, scarcity), natural factors (climate change, flood and drought), human factors (population growth, migration, demographic change, economic development, willingness to pay for water supply services, overuse), water management and delivery problems (pressure, leakages, lack of smart water meters, cost recovery, operation costs, etc.).
MDG fails to achieve its goal for access to safe water and sanitation. The chance for the success of the newly set SDG is also not different from that of MDGs, especially in some African countries. Some of the African leaders are reporting a false number of people with access to safe drinking water and sanitation to get a donation from the UN and using the donated money to buy weapons and use it to suppress the right of the people. In developing countries, improving access to safe water requires provision of good quality education and the establishment of good governance. Priorities should be given to the development of a democratic government and community empowerment.
Aluminium (Al) amongst several metals is attractive due to its ductility, malleability, good conductivity, light weight, good strength and availability in abundance (8% of earth crust is aluminium). It combines with hard materials like ceramic and offer promising metal matrix composites (MMCs) with improved properties and hence finding wide range of industrial and structural applications including aerospace, automotive, marine and military [1, 2, 3, 4, 5]. For developing aluminium-based metal matrix composites various methods are applied by various researchers in liquid metallurgy routes for mass production. Reinforcement in aluminium metal matrix composites can be in particulate, whisker, continuous or discontinuous fibres. Their addition to the base metal may vary in percentage resulting in improved properties. Composites having aluminium as base metal gives the following advantages: higher strength, improved stiffness, reduced density, survival at high temperature, high wear and corrosion resistance, improved damping capabilities [2].
\nFor developing aluminium-based metal matrix composites various methods like powder metallurgy, spray decomposition, liquid metal infiltration, squeeze casting, mechanical alloying and compo casting are applied by various researchers in liquid metallurgy routes for mass production. Most common method use for processing of aluminium MMCs by powder metallurgy (PM). Via PM route aluminium MMCs can be prepared either by direct metal oxidation (DIMOX) or by reinforcements of particles in the matrix so as to achieve high density, high hardness and strength. In MMCs generally matrix component is more in quantity and reinforcement is a contrasting phase distributed in the matrix in order to reinforce it. The reinforcement rather than making a solid solution with the base matrix, it gets distributed all around it. When three constituents are present, it is called a hybrid composite. The aim of the reinforcement particles is to give high strength and stiffness to the composite and the aim of the matrix is to bind the reinforced particles together by virtue of its adhesive and cohesive nature and to transfer the load to and between reinforcements. In case of particle reinforced composites significant improvement is obtained in the mechanical properties in terms of strength, hardness and stiffness [6, 7, 8]. As a continuous phase, the matrix controls the interlaminar strength, elevated-temperature strength and transverse properties of the composite. The matrix holds reinforcing particles in the proper orientation and position so that they can carry the intended loads and distributes the loads evenly among the reinforcements so in a way matrix allows the strength of the reinforcements to be used to their full potential. The matrix also provides a vital inelastic response so that stress concentration are reduced and internal stresses are redistributed from broken reinforcements, reinforcements increase strength, decrease the coefficient of thermal expansion, and improve the wear resistance at a cost of a reduction in ductility and in fracture toughness [9]. Amongst the various methods employed to synthesize metal matrix composites, stir casting method is preferred and used for bulk production. The particular advantages of this process lie in its simplicity, cost effectiveness, flexibility and applicability to larger size components and mass production [10]. Selection of optimum parameters of stirring speed, stirring time, uniform feed rate of particles preheating temperature of the mould results in homogenous mixing and wetting of reinforced particles with base metal. It is seen that the cost of manufacturing of composite materials using a conventional casting method is about one third to half as that of competitive methods and, for high volume production, this cost is expected to reach the level of one-tenth [11]. In MMC’s processing there are limitations with the conventional methods as conventionally produced composites are thermodynamically unstable when used at high temperature for longer time [12].
\nAs it is known that today aluminium metal matrix composites are considered the most potential material for structural and functional applications and are finding versatile application in industries due to their price including defence, aerospace, automotive and thermal management areas, as well as in sports and recreation because of their unique isotropic properties of high strength, high stiffness, reduced density (weight), high wear, abrasion and corrosion resistance and improved high temperature properties. These properties are limited in conventional alloys [1, 2, 3, 4, 5]. Some of the applications of Al MMCs are shown in Figure 1 [13]. It is reported that in aluminium-based metal matrix composites fabrication aluminium is reinforced with different reinforcing material like MgO, SiC, MnO, Al2O3 which give high mechanical properties to these composites like hardness, fracture toughness and reduced density (weight). Al MMCs consist of hard particles like SiC, WC, Al2O3, etc. and these particles make the aluminium matrix plastically constrained which improves its high temperature properties and they give superior mechanical and wear resistant properties [14].
\n(a) Piston, (b) engine with cylinder barrel, (c) piston connecting rod, (d) brake system made of aluminium (Al) metal matrix composites (MMCs) [
Researchers have reinforced Al matrix with different metallic, non-metallic and ceramic elements to have desired physical and mechanical properties. Stir casting given by Ray [15] is the best liquid state fabrication technique through which metal matrix composites can be successfully processed. In this method reinforcements are dispersed in molten metal matrix by mechanical stirring as shown in Figure 2. Al-Al2O3 (MnO2) hybrid MMCs were processed
Stir casting set up schematic diagram.
Now a days, aluminium-based metal matrix composites (Al MMCs) are used in making of piston, connecting rod, contactors, where sliding is an important factor [26]. Excessive wear of the mating components sometimes leads to catastrophic failures [27]. So study of wear properties of Al MMCs has become the need of time. Wear tests are generally conducted on ball/pin wear tester, schematic diagram as represented in Figure 3. Wear properties of many MMCs having continuous and discontinuous reinforcements like Al2O3, MnO2, SiC, graphite, mica, glass, graphite and others have been reported [28, 29, 30].
\nSchematic diagram for sliding wear ball on disc tests.
There has been increasing interest in composites and many researchers contributing their work in the area of wear analysis of aluminium composites, cermets, ceramics [30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40]. Umanath et al. [30], examined the effect of SiC and Al2O3 on dry sliding wear behaviour of Al6061 hybrid composites prepared by stir casting method, results showed that with increase in the volume content, wear decreases due to the presence of hard oxide particles. Suresh et al. [39] investigated the wear behaviour of Al6061 reinforced with Al2O3 and graphite by keeping 2 wt.% graphite constant and Al2O3 content is varied 2–8 wt.%. The reinforcement of Al2O3 and graphite improved the tribological behaviour and caused reduction in the wear of Al6061 composites. The wear decreased with the increase of speed and aluminium oxide percentage. Basavarajappa and Chandramohan [40], worked on the dry sliding wear behaviour of Al2219 reinforced with SiC (0–15 wt.%). Results shows that 15% SiC reinforced composites have better wear resistance then other composites. Raghavendra and Ramamurthy [41], examined the influence of particle size and volume fraction on wear behaviour of Al7075 alloy reinforced with Al2O3 particles, size is varied 100–200 microns and the volume fraction is varied 3–12 wt.%. Results showed that hardness increased with decrease in particle size and the wear rate was reduced with reduction in particle size. Increase in volume fraction reduced the wear and coefficient of friction. Vivekanandan et al. [42], investigated the wear resistance by varying load on the fly ash reinforced composites. Fly ash was added to the aluminium alloy and fabricated by stir casting method. At varying load it was noticed that wear rate of composites was less than the pure alloy at all loads. Kumar et al. [43], worked on the mechanical and wear behaviour of aluminium-fly ash composites formed by stir casting method. It was found that the hardness of composites increased with increase in addition of fly ash. Addition of fly ash shows improvement in the strength of composites. Strengthening of composites is due to dispersion and reinforcement. Both the wear rate and frictional force decreased with the adding of fly ash in Al6063 alloy. The aforementioned literatures show that various researchers have attempted to improve the properties of Al alloy by adding different alloying elements.
\nAl2O3 alloy when reinforced with 20 wt.% of alumina gives better wear resistance properties [44]. Al6061-alumina fibre composites abrasive wear rate is reported to be very less than the matrix alloy and is reported to have better wear resistance almost six times the matrix alloy [44]. The reason attributes to it is due to the addition of hard ceramic particles. Wear rate of Al7091 alloy and Al7091-SiC composites have almost same wear rate at 1.2 m/s sliding velocity whereas at increasing sliding velocity composites show less wear than un reinforced matrix [45, 46, 47]. TiO2 as reinforcement in Al alloys give high mechanical properties as hardness and superior corrosion resistance [11]. Al6061 is considered as candidate material to prepare MMCs owing to its better formability characteristics and option of modification of the strength of composites by adopting optimal heat treatment [26]. Dinaharan et al. [48] fabricated aluminium alloy Al6061 reinforced with ZrB2 particles (10 wt.%) and found ZrB2 particles into the aluminium matrix improved tensile strength and wear resistance but reduced ductility and corrosion resistance. The wear resistance was measured using a pin-on-disc wear apparatus at room temperature according to ASTM G99-04 standard under dry sliding conditions. The polished surface of the pin of 6 × 6 × 50 mm was slide on a hardened chromium steel disc. The test was carried out at a sliding velocity of 15 m/s, normal force of 25 N and sliding distance of 2500 m. Wear resistance for Al6061 and Al6061/10 ZrB2 is found to be 182.48 and 377.51 m/mm3. The pitting corrosion rate was measured using potentiodynamic anodic polarisation technique as per ASTM G5 (ACM Gill-5500) at room temperature and found that 0.0230 and 0.1746 mm/year corrosion rate for Al6061 and Al6061/10 ZrB2. Lus et al. [49] investigated the wear properties of
The effect of external ultrasonic treatment during solidification of a casted hypereutectic Al-Si (18% Si) alloy is studied by Unal et al. [50] and found that it has favourably affected the hardness and provided an increase of 15–20%. From the pin on disc wear tests performed under 67 N and with 1250 m sliding distance, it was revealed that the ultrasonic treated and non-treated samples exhibited similar amounts of weight loss [50]. Yamanoglu et al. [51] studied the effect of nickel (1–5 wt.%) on microstructure and pin on disc wear behaviour of pure aluminium against steel and alumina counter faces. The dry sliding wear response of the Al-
Severe wear damage was observed at low and high nickel contents. Maximum wear resistance was obtained with the addition of 3 wt.% nickel to the pure aluminium under both loads and against both counter faces. The wear resistance of the alloys increased with increasing nickel content up to 3 wt.% Ni and tended to decrease >3 wt.% Ni. The wear rate of the Al-
Summarising, literature survey shows that Al base MMCs are of huge need as they are used for various applications as for making different machine components as heavy duty pistons, aircraft generator housings, air cooled cylinder heads, engine crankcases, petrol and oil tanks, oil pans, water cooled cylinder heads, rear axle housings, flywheel housings, automotive transmission cases, oil pans, rear axle housings, brackets, water cooled cylinder blocks, various fittings and pump bodies, air brake castings, gear cases, air cooled cylinder heads, air brake castings, gear cases, air cooled cylinder heads, Internal combustion engine pistons and blocks, cylinder bodies for compressors, pumps and brakes which gets degraded with passage of time due to either wear (abrasive, adhesive) or corrosion so its becomes very essential to study their wear properties [56].
\nPresent industrial developments are associated with materials having advantageous physical, mechanical and wear characteristics that can achieve technological needs. Aluminium and its composites are best suited materials as have better properties than unreinforced materials. Beneficial properties with reduced prices have enlarged their applications. Al MMCs are used in defence, aerospace, automotive, aviation, thermal management areas in engine pistons, cylinders barrel, connection rods, elements of vehicles braking systems because of their unique properties of high hardness, high strength, high stiffness, high wear, abrasion and corrosion resistance.
\nGeneral requirements for Open Access to Horizon 2020 research project outputs are found within Guidelines on Open Access to Scientific Publication and Research Data in Horizon 2020. The guidelines, in their simplest form, state that if you are a Horizon 2020 recipient, you must ensure open access to your scientific publications by enabling them to be downloaded, printed and read online. Additionally, said publications must be peer reviewed.
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Buchholz and Erik J. Behringer",hash:"e373a3d1123dbd45fddf75d90e3e7c38",volumeInSeries:1,fullTitle:"Calcium and Signal Transduction",editors:[{id:"89438",title:"Dr.",name:"John N.",middleName:null,surname:"Buchholz",slug:"john-n.-buchholz",fullName:"John N. Buchholz",profilePictureURL:"https://mts.intechopen.com/storage/users/89438/images/6463_n.jpg",institutionString:null,institution:{name:"Loma Linda University",institutionURL:null,country:{name:"United States of America"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Plant Physiology",value:13,count:1},{group:"subseries",caption:"Human Physiology",value:12,count:2},{group:"subseries",caption:"Cell Physiology",value:11,count:8}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:1},{group:"publicationYear",caption:"2020",value:2020,count:4},{group:"publicationYear",caption:"2019",value:2019,count:5},{group:"publicationYear",caption:"2018",value:2018,count:1}],authors:{paginationCount:302,paginationItems:[{id:"198499",title:"Dr.",name:"Daniel",middleName:null,surname:"Glossman-Mitnik",slug:"daniel-glossman-mitnik",fullName:"Daniel Glossman-Mitnik",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/198499/images/system/198499.jpeg",biography:"Dr. Daniel Glossman-Mitnik is currently a Titular Researcher at the Centro de Investigación en Materiales Avanzados (CIMAV), Chihuahua, Mexico, as well as a National Researcher of Level III at the Consejo Nacional de Ciencia y Tecnología, Mexico. His research interest focuses on computational chemistry and molecular modeling of diverse systems of pharmacological, food, and alternative energy interests by resorting to DFT and Conceptual DFT. He has authored a coauthored more than 255 peer-reviewed papers, 32 book chapters, and 2 edited books. He has delivered speeches at many international and domestic conferences. He serves as a reviewer for more than eighty international journals, books, and research proposals as well as an editor for special issues of renowned scientific journals.",institutionString:"Centro de Investigación en Materiales Avanzados",institution:{name:"Centro de Investigación en Materiales Avanzados",country:{name:"Mexico"}}},{id:"76477",title:"Prof.",name:"Mirza",middleName:null,surname:"Hasanuzzaman",slug:"mirza-hasanuzzaman",fullName:"Mirza Hasanuzzaman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/76477/images/system/76477.png",biography:"Dr. Mirza Hasanuzzaman is a Professor of Agronomy at Sher-e-Bangla Agricultural University, Bangladesh. He received his Ph.D. in Plant Stress Physiology and Antioxidant Metabolism from Ehime University, Japan, with a scholarship from the Japanese Government (MEXT). Later, he completed his postdoctoral research at the Center of Molecular Biosciences, University of the Ryukyus, Japan, as a recipient of the Japan Society for the Promotion of Science (JSPS) postdoctoral fellowship. He was also the recipient of the Australian Government Endeavour Research Fellowship for postdoctoral research as an adjunct senior researcher at the University of Tasmania, Australia. Dr. Hasanuzzaman’s current work is focused on the physiological and molecular mechanisms of environmental stress tolerance. Dr. Hasanuzzaman has published more than 150 articles in peer-reviewed journals. He has edited ten books and written more than forty book chapters on important aspects of plant physiology, plant stress tolerance, and crop production. According to Scopus, Dr. Hasanuzzaman’s publications have received more than 10,500 citations with an h-index of 53. He has been named a Highly Cited Researcher by Clarivate. He is an editor and reviewer for more than fifty peer-reviewed international journals and was a recipient of the “Publons Peer Review Award” in 2017, 2018, and 2019. He has been honored by different authorities for his outstanding performance in various fields like research and education, and he has received the World Academy of Science Young Scientist Award (2014) and the University Grants Commission (UGC) Award 2018. He is a fellow of the Bangladesh Academy of Sciences (BAS) and the Royal Society of Biology.",institutionString:"Sher-e-Bangla Agricultural University",institution:{name:"Sher-e-Bangla Agricultural University",country:{name:"Bangladesh"}}},{id:"187859",title:"Prof.",name:"Kusal",middleName:"K.",surname:"Das",slug:"kusal-das",fullName:"Kusal Das",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSBDeQAO/Profile_Picture_1623411145568",biography:"Kusal K. Das is a Distinguished Chair Professor of Physiology, Shri B. M. Patil Medical College and Director, Centre for Advanced Medical Research (CAMR), BLDE (Deemed to be University), Vijayapur, Karnataka, India. Dr. Das did his M.S. and Ph.D. in Human Physiology from the University of Calcutta, Kolkata. His area of research is focused on understanding of molecular mechanisms of heavy metal activated low oxygen sensing pathways in vascular pathophysiology. He has invented a new method of estimation of serum vitamin E. His expertise in critical experimental protocols on vascular functions in experimental animals was well documented by his quality of publications. He was a Visiting Professor of Medicine at University of Leeds, United Kingdom (2014-2016) and Tulane University, New Orleans, USA (2017). For his immense contribution in medical research Ministry of Science and Technology, Government of India conferred him 'G.P. Chatterjee Memorial Research Prize-2019” and he is also the recipient of 'Dr.Raja Ramanna State Scientist Award 2015” by Government of Karnataka. He is a Fellow of the Royal Society of Biology (FRSB), London and Honorary Fellow of Karnataka Science and Technology Academy, Department of Science and Technology, Government of Karnataka.",institutionString:"BLDE (Deemed to be University), India",institution:null},{id:"243660",title:"Dr.",name:"Mallanagouda Shivanagouda",middleName:null,surname:"Biradar",slug:"mallanagouda-shivanagouda-biradar",fullName:"Mallanagouda Shivanagouda Biradar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243660/images/system/243660.jpeg",biography:"M. S. Biradar is Vice Chancellor and Professor of Medicine of\nBLDE (Deemed to be University), Vijayapura, Karnataka, India.\nHe obtained his MD with a gold medal in General Medicine and\nhas devoted himself to medical teaching, research, and administrations. He has also immensely contributed to medical research\non vascular medicine, which is reflected by his numerous publications including books and book chapters. Professor Biradar was\nalso Visiting Professor at Tulane University School of Medicine, New Orleans, USA.",institutionString:"BLDE (Deemed to be University)",institution:{name:"BLDE University",country:{name:"India"}}},{id:"289796",title:"Dr.",name:"Swastika",middleName:null,surname:"Das",slug:"swastika-das",fullName:"Swastika Das",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/289796/images/system/289796.jpeg",biography:"Swastika N. Das is Professor of Chemistry at the V. P. Dr. P. G.\nHalakatti College of Engineering and Technology, BLDE (Deemed\nto be University), Vijayapura, Karnataka, India. She obtained an\nMSc, MPhil, and PhD in Chemistry from Sambalpur University,\nOdisha, India. Her areas of research interest are medicinal chemistry, chemical kinetics, and free radical chemistry. She is a member\nof the investigators who invented a new modified method of estimation of serum vitamin E. She has authored numerous publications including book\nchapters and is a mentor of doctoral curriculum at her university.",institutionString:"BLDEA’s V.P.Dr.P.G.Halakatti College of Engineering & Technology",institution:{name:"BLDE University",country:{name:"India"}}},{id:"248459",title:"Dr.",name:"Akikazu",middleName:null,surname:"Takada",slug:"akikazu-takada",fullName:"Akikazu Takada",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248459/images/system/248459.png",biography:"Akikazu Takada was born in Japan, 1935. After graduation from\nKeio University School of Medicine and finishing his post-graduate studies, he worked at Roswell Park Memorial Institute NY,\nUSA. He then took a professorship at Hamamatsu University\nSchool of Medicine. In thrombosis studies, he found the SK\npotentiator that enhances plasminogen activation by streptokinase. He is very much interested in simultaneous measurements\nof fatty acids, amino acids, and tryptophan degradation products. By using fatty\nacid analyses, he indicated that plasma levels of trans-fatty acids of old men were\nfar higher in the US than Japanese men. . He also showed that eicosapentaenoic acid\n(EPA) and docosahexaenoic acid (DHA) levels are higher, and arachidonic acid\nlevels are lower in Japanese than US people. By using simultaneous LC/MS analyses\nof plasma levels of tryptophan metabolites, he recently found that plasma levels of\nserotonin, kynurenine, or 5-HIAA were higher in patients of mono- and bipolar\ndepression, which are significantly different from observations reported before. In\nview of recent reports that plasma tryptophan metabolites are mainly produced by\nmicrobiota. He is now working on the relationships between microbiota and depression or autism.",institutionString:"Hamamatsu University School of Medicine",institution:{name:"Hamamatsu University School of Medicine",country:{name:"Japan"}}},{id:"137240",title:"Prof.",name:"Mohammed",middleName:null,surname:"Khalid",slug:"mohammed-khalid",fullName:"Mohammed Khalid",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/137240/images/system/137240.png",biography:"Mohammed Khalid received his B.S. degree in chemistry in 2000 and Ph.D. degree in physical chemistry in 2007 from the University of Khartoum, Sudan. He moved to School of Chemistry, Faculty of Science, University of Sydney, Australia in 2009 and joined Dr. Ron Clarke as a postdoctoral fellow where he worked on the interaction of ATP with the phosphoenzyme of the Na+/K+-ATPase and dual mechanisms of allosteric acceleration of the Na+/K+-ATPase by ATP; then he went back to Department of Chemistry, University of Khartoum as an assistant professor, and in 2014 he was promoted as an associate professor. In 2011, he joined the staff of Department of Chemistry at Taif University, Saudi Arabia, where he is currently an assistant professor. His research interests include the following: P-Type ATPase enzyme kinetics and mechanisms, kinetics and mechanisms of redox reactions, autocatalytic reactions, computational enzyme kinetics, allosteric acceleration of P-type ATPases by ATP, exploring of allosteric sites of ATPases, and interaction of ATP with ATPases located in cell membranes.",institutionString:"Taif University",institution:{name:"Taif University",country:{name:"Saudi Arabia"}}},{id:"63810",title:"Prof.",name:"Jorge",middleName:null,surname:"Morales-Montor",slug:"jorge-morales-montor",fullName:"Jorge Morales-Montor",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/63810/images/system/63810.png",biography:"Dr. Jorge Morales-Montor was recognized with the Lola and Igo Flisser PUIS Award for best graduate thesis at the national level in the field of parasitology. He received a fellowship from the Fogarty Foundation to perform postdoctoral research stay at the University of Georgia. He has 153 journal articles to his credit. He has also edited several books and published more than fifty-five book chapters. He is a member of the Mexican Academy of Sciences, Latin American Academy of Sciences, and the National Academy of Medicine. He has received more than thirty-five awards and has supervised numerous bachelor’s, master’s, and Ph.D. students. Dr. Morales-Montor is the past president of the Mexican Society of Parasitology.",institutionString:"National Autonomous University of Mexico",institution:{name:"National Autonomous University of Mexico",country:{name:"Mexico"}}},{id:"217215",title:"Dr.",name:"Palash",middleName:null,surname:"Mandal",slug:"palash-mandal",fullName:"Palash Mandal",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/217215/images/system/217215.jpeg",biography:null,institutionString:"Charusat University",institution:null},{id:"49739",title:"Dr.",name:"Leszek",middleName:null,surname:"Szablewski",slug:"leszek-szablewski",fullName:"Leszek Szablewski",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49739/images/system/49739.jpg",biography:"Leszek Szablewski is a professor of medical sciences. He received his M.S. in the Faculty of Biology from the University of Warsaw and his PhD degree from the Institute of Experimental Biology Polish Academy of Sciences. He habilitated in the Medical University of Warsaw, and he obtained his degree of Professor from the President of Poland. Professor Szablewski is the Head of Chair and Department of General Biology and Parasitology, Medical University of Warsaw. Professor Szablewski has published over 80 peer-reviewed papers in journals such as Journal of Alzheimer’s Disease, Biochim. Biophys. Acta Reviews of Cancer, Biol. Chem., J. Biomed. Sci., and Diabetes/Metabol. Res. Rev, Endocrine. He is the author of two books and four book chapters. He has edited four books, written 15 scripts for students, is the ad hoc reviewer of over 30 peer-reviewed journals, and editorial member of peer-reviewed journals. Prof. Szablewski’s research focuses on cell physiology, genetics, and pathophysiology. He works on the damage caused by lack of glucose homeostasis and changes in the expression and/or function of glucose transporters due to various diseases. He has given lectures, seminars, and exercises for students at the Medical University.",institutionString:"Medical University of Warsaw",institution:{name:"Medical University of Warsaw",country:{name:"Poland"}}},{id:"173123",title:"Dr.",name:"Maitham",middleName:null,surname:"Khajah",slug:"maitham-khajah",fullName:"Maitham Khajah",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/173123/images/system/173123.jpeg",biography:"Dr. Maitham A. Khajah received his degree in Pharmacy from Faculty of Pharmacy, Kuwait University, in 2003 and obtained his PhD degree in December 2009 from the University of Calgary, Canada (Gastrointestinal Science and Immunology). Since January 2010 he has been assistant professor in Kuwait University, Faculty of Pharmacy, Department of Pharmacology and Therapeutics. His research interest are molecular targets for the treatment of inflammatory bowel disease (IBD) and the mechanisms responsible for immune cell chemotaxis. He cosupervised many students for the MSc Molecular Biology Program, College of Graduate Studies, Kuwait University. Ever since joining Kuwait University in 2010, he got various grants as PI and Co-I. He was awarded the Best Young Researcher Award by Kuwait University, Research Sector, for the Year 2013–2014. He was a member in the organizing committee for three conferences organized by Kuwait University, Faculty of Pharmacy, as cochair and a member in the scientific committee (the 3rd, 4th, and 5th Kuwait International Pharmacy Conference).",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"195136",title:"Dr.",name:"Aya",middleName:null,surname:"Adel",slug:"aya-adel",fullName:"Aya Adel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/195136/images/system/195136.jpg",biography:"Dr. Adel works as an Assistant Lecturer in the unit of Phoniatrics, Department of Otolaryngology, Ain Shams University in Cairo, Egypt. Dr. Adel is especially interested in joint attention and its impairment in autism spectrum disorder",institutionString:"Ain Shams University",institution:{name:"Ain Shams University",country:{name:"Egypt"}}},{id:"94911",title:"Dr.",name:"Boulenouar",middleName:null,surname:"Mesraoua",slug:"boulenouar-mesraoua",fullName:"Boulenouar Mesraoua",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94911/images/system/94911.png",biography:"Dr Boulenouar Mesraoua is the Associate Professor of Clinical Neurology at Weill Cornell Medical College-Qatar and a Consultant Neurologist at Hamad Medical Corporation at the Neuroscience Department; He graduated as a Medical Doctor from the University of Oran, Algeria; he then moved to Belgium, the City of Liege, for a Residency in Internal Medicine and Neurology at Liege University; after getting the Belgian Board of Neurology (with high marks), he went to the National Hospital for Nervous Diseases, Queen Square, London, United Kingdom for a fellowship in Clinical Neurophysiology, under Pr Willison ; Dr Mesraoua had also further training in Epilepsy and Continuous EEG Monitoring for two years (from 2001-2003) in the Neurophysiology department of Zurich University, Switzerland, under late Pr Hans Gregor Wieser ,an internationally known epileptologist expert. \n\nDr B. Mesraoua is the Director of the Neurology Fellowship Program at the Neurology Section and an active member of the newly created Comprehensive Epilepsy Program at Hamad General Hospital, Doha, Qatar; he is also Assistant Director of the Residency Program at the Qatar Medical School. \nDr B. Mesraoua's main interests are Epilepsy, Multiple Sclerosis, and Clinical Neurology; He is the Chairman and the Organizer of the well known Qatar Epilepsy Symposium, he is running yearly for the past 14 years and which is considered a landmark in the Gulf region; He has also started last year , together with other epileptologists from Qatar, the region and elsewhere, a yearly International Epilepsy School Course, which was attended by many neurologists from the Area.\n\nInternationally, Dr Mesraoua is an active and elected member of the Commission on Eastern Mediterranean Region (EMR ) , a regional branch of the International League Against Epilepsy (ILAE), where he represents the Middle East and North Africa(MENA ) and where he holds the position of chief of the Epilepsy Epidemiology Section; Dr Mesraoua is a member of the American Academy of Neurology, the Europeen Academy of Neurology and the American Epilepsy Society.\n\nDr Mesraoua's main objectives are to encourage frequent gathering of the epileptologists/neurologists from the MENA region and the rest of the world, promote Epilepsy Teaching in the MENA Region, and encourage multicenter studies involving neurologists and epileptologists in the MENA region, particularly epilepsy epidemiological studies. \n\nDr. Mesraoua is the recipient of two research Grants, as the Lead Principal Investigator (750.000 USD and 250.000 USD) from the Qatar National Research Fund (QNRF) and the Hamad Hospital Internal Research Grant (IRGC), on the following topics : “Continuous EEG Monitoring in the ICU “ and on “Alpha-lactoalbumin , proof of concept in the treatment of epilepsy” .Dr Mesraoua is a reviewer for the journal \"seizures\" (Europeen Epilepsy Journal ) as well as dove journals ; Dr Mesraoua is the author and co-author of many peer reviewed publications and four book chapters in the field of Epilepsy and Clinical Neurology",institutionString:"Weill Cornell Medical College in Qatar",institution:{name:"Weill Cornell Medical College in Qatar",country:{name:"Qatar"}}},{id:"282429",title:"Prof.",name:"Covanis",middleName:null,surname:"Athanasios",slug:"covanis-athanasios",fullName:"Covanis Athanasios",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/282429/images/system/282429.jpg",biography:null,institutionString:"Neurology-Neurophysiology Department of the Children Hospital Agia Sophia",institution:null},{id:"190980",title:"Prof.",name:"Marwa",middleName:null,surname:"Mahmoud Saleh",slug:"marwa-mahmoud-saleh",fullName:"Marwa Mahmoud Saleh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/190980/images/system/190980.jpg",biography:"Professor Marwa Mahmoud Saleh is a doctor of medicine and currently works in the unit of Phoniatrics, Department of Otolaryngology, Ain Shams University in Cairo, Egypt. She got her doctoral degree in 1991 and her doctoral thesis was accomplished in the University of Iowa, United States. Her publications covered a multitude of topics as videokymography, cochlear implants, stuttering, and dysphagia. She has lectured Egyptian phonology for many years. Her recent research interest is joint attention in autism.",institutionString:"Ain Shams University",institution:{name:"Ain Shams University",country:{name:"Egypt"}}},{id:"259190",title:"Dr.",name:"Syed Ali Raza",middleName:null,surname:"Naqvi",slug:"syed-ali-raza-naqvi",fullName:"Syed Ali Raza Naqvi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259190/images/system/259190.png",biography:"Dr. Naqvi is a radioanalytical chemist and is working as an associate professor of analytical chemistry in the Department of Chemistry, Government College University, Faisalabad, Pakistan. Advance separation techniques, nuclear analytical techniques and radiopharmaceutical analysis are the main courses that he is teaching to graduate and post-graduate students. In the research area, he is focusing on the development of organic- and biomolecule-based radiopharmaceuticals for diagnosis and therapy of infectious and cancerous diseases. Under the supervision of Dr. Naqvi, three students have completed their Ph.D. degrees and 41 students have completed their MS degrees. He has completed three research projects and is currently working on 2 projects entitled “Radiolabeling of fluoroquinolone derivatives for the diagnosis of deep-seated bacterial infections” and “Radiolabeled minigastrin peptides for diagnosis and therapy of NETs”. He has published about 100 research articles in international reputed journals and 7 book chapters. 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Many parasitic diseases are classified as neglected tropical diseases because they have received minimal funding over recent years and, in many cases, are under-reported despite the critical role they play in morbidity and mortality among human and animal hosts. The current topic, Parasitic Infectious Diseases, in the Infectious Diseases Series aims to publish studies on the systematics, epidemiology, molecular biology, genomics, pathogenesis, genetics, and clinical significance of parasitic diseases from blood borne to intestinal parasites as well as zoonotic parasites. We hope to cover all aspects of parasitic diseases to provide current and relevant research data on these very important diseases. In the current atmosphere of the Coronavirus pandemic, communities around the world, particularly those in different underdeveloped areas, are faced with the growing challenges of the high burden of parasitic diseases. At the same time, they are faced with the Covid-19 pandemic leading to what some authors have called potential syndemics that might worsen the outcome of such infections. Therefore, it is important to conduct studies that examine parasitic infections in the context of the coronavirus pandemic for the benefit of all communities to help foster more informed decisions for the betterment of human and animal health.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/5.jpg",keywords:"Blood Borne Parasites, Intestinal Parasites, Protozoa, Helminths, Arthropods, Water Born Parasites, Epidemiology, Molecular Biology, Systematics, Genomics, Proteomics, Ecology"},{id:"6",title:"Viral Infectious Diseases",scope:"The Viral Infectious Diseases Book Series aims to provide a comprehensive overview of recent research trends and discoveries in various viral infectious diseases emerging around the globe. The emergence of any viral disease is hard to anticipate, which often contributes to death. A viral disease can be defined as an infectious disease that has recently appeared within a population or exists in nature with the rapid expansion of incident or geographic range. This series will focus on various crucial factors related to emerging viral infectious diseases, including epidemiology, pathogenesis, host immune response, clinical manifestations, diagnosis, treatment, and clinical recommendations for managing viral infectious diseases, highlighting the recent issues with future directions for effective therapeutic strategies.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/6.jpg",keywords:"Novel Viruses, Virus Transmission, Virus Evolution, Molecular Virology, Control and Prevention, Virus-host Interaction"}],annualVolumeBook:{},thematicCollection:[],selectedSeries:null,selectedSubseries:null},seriesLanding:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. This Biochemistry Series will address the current research on biomolecules and the emerging trends with great promise.",coverUrl:"https://cdn.intechopen.com/series/covers/11.jpg",latestPublicationDate:"May 15th, 2022",hasOnlineFirst:!0,numberOfOpenTopics:4,numberOfPublishedChapters:286,numberOfPublishedBooks:27,editor:{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},subseries:[{id:"14",title:"Cell and Molecular Biology",keywords:"Omics (Transcriptomics; Proteomics; Metabolomics), Molecular Biology, Cell Biology, Signal Transduction and Regulation, Cell Growth and Differentiation, Apoptosis, Necroptosis, Ferroptosis, Autophagy, Cell Cycle, Macromolecules and Complexes, Gene Expression",scope:"The Cell and Molecular Biology topic within the IntechOpen Biochemistry Series aims to rapidly publish contributions on all aspects of cell and molecular biology, including aspects related to biochemical and genetic research (not only in humans but all living beings). We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics include, but are not limited to: Advanced techniques of cellular and molecular biology (Molecular methodologies, imaging techniques, and bioinformatics); Biological activities at the molecular level; Biological processes of cell functions, cell division, senescence, maintenance, and cell death; Biomolecules interactions; Cancer; Cell biology; Chemical biology; Computational biology; Cytochemistry; Developmental biology; Disease mechanisms and therapeutics; DNA, and RNA metabolism; Gene functions, genetics, and genomics; Genetics; Immunology; Medical microbiology; Molecular biology; Molecular genetics; Molecular processes of cell and organelle dynamics; Neuroscience; Protein biosynthesis, degradation, and functions; Regulation of molecular interactions in a cell; Signalling networks and system biology; Structural biology; Virology and microbiology.",annualVolume:11410,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"79367",title:"Dr.",name:"Ana Isabel",middleName:null,surname:"Flores",fullName:"Ana Isabel Flores",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRpIOQA0/Profile_Picture_1632418099564",institutionString:null,institution:{name:"Hospital Universitario 12 De Octubre",institutionURL:null,country:{name:"Spain"}}},{id:"328234",title:"Ph.D.",name:"Christian",middleName:null,surname:"Palavecino",fullName:"Christian Palavecino",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000030DhEhQAK/Profile_Picture_1628835318625",institutionString:null,institution:{name:"Central University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"186585",title:"Dr.",name:"Francisco Javier",middleName:null,surname:"Martin-Romero",fullName:"Francisco Javier Martin-Romero",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSB3HQAW/Profile_Picture_1631258137641",institutionString:null,institution:{name:"University of Extremadura",institutionURL:null,country:{name:"Spain"}}}]},{id:"15",title:"Chemical Biology",keywords:"Phenolic Compounds, Essential Oils, Modification of Biomolecules, Glycobiology, Combinatorial Chemistry, Therapeutic peptides, Enzyme Inhibitors",scope:"Chemical biology spans the fields of chemistry and biology involving the application of biological and chemical molecules and techniques. In recent years, the application of chemistry to biological molecules has gained significant interest in medicinal and pharmacological studies. This topic will be devoted to understanding the interplay between biomolecules and chemical compounds, their structure and function, and their potential applications in related fields. Being a part of the biochemistry discipline, the ideas and concepts that have emerged from Chemical Biology have affected other related areas. This topic will closely deal with all emerging trends in this discipline.",annualVolume:11411,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null,editorialBoard:[{id:"241413",title:"Dr.",name:"Azhar",middleName:null,surname:"Rasul",fullName:"Azhar Rasul",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRT1oQAG/Profile_Picture_1635251978933",institutionString:null,institution:{name:"Government College University, Faisalabad",institutionURL:null,country:{name:"Pakistan"}}},{id:"178316",title:"Ph.D.",name:"Sergey",middleName:null,surname:"Sedykh",fullName:"Sergey Sedykh",profilePictureURL:"https://mts.intechopen.com/storage/users/178316/images/system/178316.jfif",institutionString:null,institution:{name:"Novosibirsk State University",institutionURL:null,country:{name:"Russia"}}}]},{id:"17",title:"Metabolism",keywords:"Biomolecules Metabolism, Energy Metabolism, Metabolic Pathways, Key Metabolic Enzymes, Metabolic Adaptation",scope:"Metabolism is frequently defined in biochemistry textbooks as the overall process that allows living systems to acquire and use the free energy they need for their vital functions or the chemical processes that occur within a living organism to maintain life. Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. Thus all studies on metabolism will be considered for publication.",annualVolume:11413,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",fullName:"Anca Pantea Stoian",profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"203824",title:"Dr.",name:"Attilio",middleName:null,surname:"Rigotti",fullName:"Attilio Rigotti",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institutionString:null,institution:{name:"Pontifical Catholic University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"300470",title:"Dr.",name:"Yanfei (Jacob)",middleName:null,surname:"Qi",fullName:"Yanfei (Jacob) Qi",profilePictureURL:"https://mts.intechopen.com/storage/users/300470/images/system/300470.jpg",institutionString:null,institution:{name:"Centenary Institute of Cancer Medicine and Cell Biology",institutionURL:null,country:{name:"Australia"}}}]},{id:"18",title:"Proteomics",keywords:"Mono- and Two-Dimensional Gel Electrophoresis (1-and 2-DE), Liquid Chromatography (LC), Mass Spectrometry/Tandem Mass Spectrometry (MS; MS/MS), Proteins",scope:"With the recognition that the human genome cannot provide answers to the etiology of a disorder, changes in the proteins expressed by a genome became a focus in research. Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. The Proteomics topic aims to attract contributions on all aspects of MS-based proteomics that, by pushing the boundaries of MS capabilities, may address biological problems that have not been resolved yet.",annualVolume:11414,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null,editorialBoard:[{id:"72288",title:"Dr.",name:"Arli Aditya",middleName:null,surname:"Parikesit",fullName:"Arli Aditya Parikesit",profilePictureURL:"https://mts.intechopen.com/storage/users/72288/images/system/72288.jpg",institutionString:null,institution:{name:"Indonesia International Institute for Life Sciences",institutionURL:null,country:{name:"Indonesia"}}},{id:"40928",title:"Dr.",name:"Cesar",middleName:null,surname:"Lopez-Camarillo",fullName:"Cesar Lopez-Camarillo",profilePictureURL:"https://mts.intechopen.com/storage/users/40928/images/3884_n.png",institutionString:null,institution:{name:"Universidad Autónoma de la Ciudad de México",institutionURL:null,country:{name:"Mexico"}}},{id:"81926",title:"Dr.",name:"Shymaa",middleName:null,surname:"Enany",fullName:"Shymaa Enany",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRqB9QAK/Profile_Picture_1626163237970",institutionString:null,institution:{name:"Suez Canal University",institutionURL:null,country:{name:"Egypt"}}}]}]}},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"profile.detail",path:"/profiles/58854",hash:"",query:{},params:{id:"58854"},fullPath:"/profiles/58854",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()