Mihaela Pertea
Department of Plastic Surgery and Reconstructive Microsurgery, University of Medicine and Pharmacy "Grigore T. Popa", 700111 Iasi, Romania
Mihaela Pertea
Chapters authored
Deep Vein Thrombosis in Pregnancy and Postpartum; Are Sulfur-Containing Amino Acids Involved in Thrombophilia Condition?
Thrombophilia is a life-threatening condition causing deep vein thrombosis associated with pulmonary thromboembolism. In pregnancy and postpartum, the risk of venous thromboembolism is 5 times higher; in association with pre-existing thrombophilia becoming up to 30 times higher. The main cause of mortality at birth in underdeveloped countries is hemorrhage, while in developed countries, mortality is caused by thromboembolic complications. A peculiarity of pregnancy nowadays is the advanced age of the mother at the time of conception and assisted reproduction, both conditions presenting thrombotic risks through hyperstimulation that favors hemoconcentration as a result of high levels of estradiol generation and/or immobilization, which favors hypercoagulability and DVT respectively. In this chapter, we have summarized the most important connection between thrombophilia, deep vein thrombosis and Hcy involvement in pregnancy and postpartum conditions.
Part of the book: Cysteine - New insights [Working title]