Motor performance (per unit calculation) versus slot fill factor, at a given slot area and a given DC copper losses.
\r\n\t
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Dr. Li’s research focuses on the vibration, fatigue, damage, fracture, reliability, safety and durability of aircraft and aero engine. In this research area, he is the first author of 184 SCI journal publications (49 JCR Q1), 8 monographs, 3 edited books, 3 textbooks, 3 book chapters, 30 Chinese Patents, 2 US Patents, 2 Chinese Software Copyright, and more than 20 refereed conference proceedings. He has been involved in different projects related to structural damage, reliability, and airworthiness design for aircraft and aero engines, supported by the Natural Science Foundation of China, COMAC Company, and AECC Commercial Aircraft Engine Company.",institutionString:"Nanjing University of Aeronautics and Astronautics",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"5",totalChapterViews:"0",totalEditedBooks:"3",institution:{name:"Nanjing University of Aeronautics and Astronautics",institutionURL:null,country:{name:"China"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"14",title:"Materials Science",slug:"materials-science"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"478197",firstName:"Veronika",lastName:"Radosavac",middleName:null,title:"Dr.",imageUrl:"//cdnintech.com/web/frontend/www/assets/author.svg",email:"veronika@intechopen.com",biography:null}},relatedBooks:[{type:"book",id:"7404",title:"Hysteresis of Composites",subtitle:null,isOpenForSubmission:!1,hash:"8540fa2378dbb92e50411cfebfb853a6",slug:"hysteresis-of-composites",bookSignature:"Li Longbiao",coverURL:"https://cdn.intechopen.com/books/images_new/7404.jpg",editedByType:"Edited by",editors:[{id:"302409",title:"Dr.",name:"Longbiao",surname:"Li",slug:"longbiao-li",fullName:"Longbiao Li"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10690",title:"Air Traffic Management and Control",subtitle:null,isOpenForSubmission:!1,hash:"9b3aae480119950f33ef5b33f43c2598",slug:"air-traffic-management-and-control",bookSignature:"Longbiao Li",coverURL:"https://cdn.intechopen.com/books/images_new/10690.jpg",editedByType:"Edited by",editors:[{id:"302409",title:"Dr.",name:"Longbiao",surname:"Li",slug:"longbiao-li",fullName:"Longbiao Li"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10224",title:"Safety and Risk Assessment of Civil Aircraft during Operation",subtitle:null,isOpenForSubmission:!1,hash:"d966066f4fa44f6b320cd9b40ed66bbd",slug:"safety-and-risk-assessment-of-civil-aircraft-during-operation",bookSignature:"Longbiao Li",coverURL:"https://cdn.intechopen.com/books/images_new/10224.jpg",editedByType:"Edited by",editors:[{id:"302409",title:"Dr.",name:"Longbiao",surname:"Li",slug:"longbiao-li",fullName:"Longbiao Li"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6320",title:"Advances in Glass Science and Technology",subtitle:null,isOpenForSubmission:!1,hash:"6d0a32a0cf9806bccd04101a8b6e1b95",slug:"advances-in-glass-science-and-technology",bookSignature:"Vincenzo M. 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Kawsar Alam",coverURL:"https://cdn.intechopen.com/books/images_new/6805.jpg",editedByType:"Edited by",editors:[{id:"199691",title:"Dr.",name:"Md. Kawsar",surname:"Alam",slug:"md.-kawsar-alam",fullName:"Md. Kawsar Alam"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"75067",title:"Very Low Voltage and High Efficiency Motorisation for Electric Vehicles",doi:"10.5772/intechopen.95832",slug:"very-low-voltage-and-high-efficiency-motorisation-for-electric-vehicles",body:'The need for a higher competitive electrical machines, mainly in terms of power density and efficiency, is increasing especially in embedded applications (aerospace, Vertical Take-Off and Landing, Electric Vehicle, etc.); these performances are a key differentiator between competitors. As a rule of thumb, nowadays, a good power-to-weight ratio of PM electric motors is around 3 kW/kg (EMAG + mechanical packaging) [1]. Nevertheless, higher values have been proclaimed by many companies and star-ups, but for experimental prototypes where the maturity of the product is still questionable. The definition of the power to weight ratio is still versatile and controversial because, on one hand, the estimation of the total motor weight relies on many parts where some of them are not always considered in the calculation: EMAG, mechanics, coolant weight (in some cases is shared with the system), cables, power electronic, etc., on the other hand, the flexible definition of the output power (continuous or transient).
The opportunities for achieving a big improvement against the state of the art are very limited and challenging due to the very small degree of freedom.
The following expression provides the basic relationship of the sizing electromagnetic power of electric motors (rotational movement). This expression highlight some, but not all, obvious paths to follow in order to improve the performance.
Where, C: constant coefficient, kw: winding factor, λe: electric loading (number of ampere-conductors per meter around the bore of the stator), B: magnetic loading (magnetic flux-density in the airgap), D: rotor diameter, Ls: stator corepack length (active length), and Ω: rotation speed.
These are the main routes to enhance the performance of the electrical machines:
The ferromagnetic materials: there is no noticeable progress since the last 30 years on the electrical steels. The Iron Cobalt alloy (FeCo) is still the best electrical steel point of highest saturation level around 2.4 T and lowest coreloss (at a given lamination thickness and heat treatment), however is much more expensive and require a specific manufacturing process (specific annealing etc.) in comparison with other more conventional electrical steels like the Iron-Silicon alloy (FeSi) [1].
The permanent magnet grade: the catalog of the permanent magnet suppliers has been extended in the last few years, even though there is no noticeable since many years. High-grade magnets work well at development level (prototype), but they show some serious limitations when it comes to use them in a harsh environment (NdFeB are not suitable for high temperature > 200°C), or to consider the industrialization (high volume production/cost).
The thermal management: cooling is a key subject nowadays to push the performance of electric motors beyond certain limits. Some novel cooling technologies are very promising but not fully mature yet, such as: hollow conductor (technique so far reserved for high power machines > MW), flooded slot cooling, …
For a given specification, the selection of an efficient cooling technique can be very challenging because it can compromise the overall performance of the system (optimisation issue) by adding cost, complexity, and weight, and compromising the reliability as well, which can be prohibitive in some embedded applications.
The bar winding presented in this chapter permits to improve the heat exchange in both the slots and the end-windings [1, 2, 3].
The rotational speed: this has been always a research topic of interest. Very high speed motors have their own limitations and constraints, mainly mechanical (rotor sleeving, integrity of the structure,…).
Many applications require a rotational speed of few 1000 rpm with a minimum stage of reduction between the electric motor and the driven load (typically driven propeller of electric VTOL), which prohibit the use of very high speed motors.
The fundamental frequency: this is largely exploited nowadays; high fundamental frequency reduce the dimensions and the mass of electrical machines by making the stator back iron and the rotor yoke very thin (few millimeters). High fundamental frequency usually leads to a high pole count paired with a concentrated winding around the tooth (q < 1) which offer a very compact motor due to the short end-windings [4].
A thin stator back iron will noticeably reduce the thermal resistance between the copper and the external cooling sources, especially for forced air-cooled motors via the housing fins.
Furthermore, halbach arrangement is suitable for this type of motors and help getting rid of the rotor yoke, by, for example, gluing the magnets on a non-magnetic wheel such as aluminum or composite material in order to further reduce the weight.
The electric loading: this is an avenue for improvement, especially through the use of superconducting materials. There definitely has been a lot of progress, but the materials with low critical temperature have not given the expected results so far and the associated cooling devices prohibits any on-board use.
We suggest in this chapter to focus on a different approach to increase the performance of the electric motors by using a new winding technique with solid bars in order to improve the copper fill factor in the slot [1, 2, 3]. The fill factor of a conventional electrical machine with random round wire is always less than 45% (CSA pure copper/CSA naked slot). The use of a solid conductor allows reaching higher fill factor at least 75% and consequently enhances the performance of electric motors.
Despite these attractive advantages, the use of solid bar in the armature winding of synchronous machines has been reserved to very limited applications such as MW turbo generators and the aircraft 3-stage generators (APUG, VFG, IDG). Such a winding type becomes more and more common while being introduced in the electric and hybrid electric vehicle for a medium power ranging from 40 kW to 200 kW, it is called hairpin winding. A winding of this ilk is ideal to provide the needed performance when the traction motor of the vehicle required to develop high torque at low speed or during accelerations.
The winding covered in this chapter is different from the hairpin winding and has been used for many applications: electric vehicle, small sport car, utility vehicles, full electric boat,…
The performance of any electrical machine is intimately linked to the slot fill factor. There few definition of slot fill factor, here we consider the ratio of total pure copper in one slot per total slot area.
In a conventional overlapping winding with round wire, the copper fill factor is always mediocre and it is very complicated to exploit beyond 45% of the slot area (non-segmented stator), so almost half of the slot volume is inactive and occupied by the air and the different insulation materials (cf. Figure 1).
Illustration of the slot fill factor with round wire and with the solid bar proposed in this paper.
As regards the solid conductor winding we propose here, the slot fill factor is typically higher than 75%. Indeed, the bar is housed in a rectangular slot slightly larger than the bar to allow the slot insulation (slot liner). The slot dimensions are equal to: wslot = wbar + δsl and hslot = hbar + δsl, where δsl is the gap between the slot wall and the solid conductor intended to receive the slot liner. δsl typically lies between 0.3 mm and 0.5 mm (V < 1 kV and P < 300 kW).
Improving the slot fill factor with solid bar will introduce these benefits:
At a given electric loading and given DC copper loss: when the copper fill factor is improved, the height/size of the slot can be reduced in the same proportion. A shorter slot leads to a smaller and lighter motor by reducing its outer diameter; or, at a given motor outer diameter (envelope), the stator inner diameter can be increased and, hence, the output torque.
At a given slot area and a given DC copper losses: a better copper fill factor will permit to increase the torque-to weight ratio of the motor while keeping the same efficiency. For example, increasing the fill factor from 40% with round wire to 80% with solid bars (both values are practical) will permit to multiply the current in the slot by √2 and consequently getting +18% torque-to-weight ratio assuming that the copper is around 20% of the total EMAG weight. A per unit calculation is shown in the Table 1 in order to give an overview of the motor performance for a copper fill factor lying between 20% and 90%, where the baseline case is 40% fill factor (well known value for a standard manufacturing).
20% fill factor | 40% fill factor (baseline) | 80% fill factor | 90% fill factor | |
---|---|---|---|---|
CSA copper in the slot [PU] | 0.5 | 2 | 2.25 | |
Total current in the slot [PU] | 0.7071 | 1.4142 | 1.5 | |
Current density | 1.4142 | 0.7071 | 0.6667 | |
Electric loading | 0.7071 | 1.4142 | 1.5000 | |
Copper loss [PU] | 1 | 1 | 1 | |
Copper mass [PU] | 0.5 | 2 | 2.25 | |
Torque [PU] | 0.7071 | 1.4142 | 1.5 | |
Total EMAG weight [PU] | 0.9 | 1.2 | 1.25 | |
Copper weight / Total EMAG weight ratio [PU] | 0.111 | 0.333 | 0.360 | |
Torque-to-weight ratio [PU] | 0.7857 | 1.18 | 1.20 |
Motor performance (per unit calculation) versus slot fill factor, at a given slot area and a given DC copper losses.
In practice, it might be possible to increase the copper loss density in the solid bar winding because the thermal exchanges between the copper and the stator corepack and between the end-windings and the housing are improved (cf. Figure 1).
Enhancing the thermal management with solid bar will permit to homogenize the copper temperature and suppress the hotspots, which makes the winding insulation more reliable.
The end-windings are always representing an Achilles heel for electric actuators. Indeed, they dissipate the energy without contributing to the creation of useful power. Hotspots usually occur in this part of the winding. The prediction of the volume of the end-windings is difficult, because the geometry is complex and dependent on several poorly controlled factors, such as the winding topology, the tact of the engineer or the machine carrying out the winding,…
In practice, to approximately take into account the loss in the end-windings with round wire in the calculation of the efficiency, the designers multiply the Joule loss dissipated in the slots by an add-on factor generally lying between 1.3 and 2 (distributed winding). It is not unusual to encounter a short electrical machine with end-winding factor of 2; it means that the half-turn axial length is equal to the double of the stator active length (stack length) and therefore the loss in the end-windings are equal to the loss in the active copper located in the slots.
For the bar winding that we propose here, the end-windings volume can be precisely estimated via the relation (13) or (14). Accordingly, the end-windings Joule loss can be accurately predicted as well as the global efficiency of the machine.
Furthermore, we gain in space (shorter machine) and weight and thus better power density and efficiency (Figure 2).
End-windings of round wire winding (left) - End-windings of solid bar winding (right).
Despite the fact that some performance of the electrical machine are closely linked to the slotting effect, the slot opening width is not really an optimization parameter in the case of a conventional winding, because it is imposed by the winder to facilitate the insertion of the coils into the slots.
The performance related to the slot opening are:
Rated torque: the modulation of the flux density caused by the slotting effect impairs the fundamental of the airgap flux density (larger effective airgap) and consequently affects the produced torque.
Cogging torque: the smoother the stator bore the lower the slotting effect and the cogging torque. This improves the acoustic and vibration behavior of the machine.
Rotor eddy-current losses in the magnets, in the conducting retaining sleeve, and in the solid iron rotor: a low slot opening width will significantly mitigate the airgap reluctance modulation seen by the rotor and consequently less induced loss and better efficiency.
The windage loss: is proportional to the roughness coefficient that depends directly on the surface state of the rotor and stator. It is minimal (∼1) for a machine with a smooth rotor and low slot opening.
In the case of bar winding, there is no particular constraint on the slot opening because the conductors are inserted by sliding into the stator, which allows to optimize it and to improve the aforementioned performance. The optimum slot opening width with the bar winding proposed in this paper is typically lying between 0.5 mm and 1 mm. It corresponds to a trade-off between a minimal slotting effect and minimal leakage flux (highest produced torque).
Unlike the malleable round wire winding, the main complexity of a bar distributed winding is the connection of the overlapping poles at the end-windings level. To overcome this difficulty we have designed a relatively simple system to enable the end-windings connection by means of bent bars alternating overhead and frontally as shown in Figure 3, we called them “bow bar” and “crook bar”. The latter are brazed to the bars located in the slots and they have the same cross section (but could be different shape). According to the Figure 3, we can distinguish three different lengths of the bars located in the slots: short bar (bow/bow connection), medium bar (bow/crook), and long bar (crook/crook).
Illustration of the three different end-winding connections, from the top to the bottom: Bow/bow connection, bow/crook connection, and crook/crook connection.
The assembly of the proposed bar winding can be broken down into four main steps:
Cutting of the bars under the different lengths and then the bending of the end-windings connection bars.
Insulating the stator core with a slot liner made from sheets of material such as: Nomex, Kapton, Dacron-Mylar-Dacron,…
Insertion of the bars into the slots and joining them to the end-windings bars. Depends on the application (temperature and vibration level), we propose two approaches to connect the end-windings, the first method is based on the soldering only, whereas the second one is using both soldering and screws into threaded holes drilled in the copper.
Finally, the encapsulation or impregnation of the winding to reinforce the electrical insulation, increase the mechanical strength of the bars, and improve the heat exchange (especially at the end-windings).
In this part, we propose some practical and generalized analytical relationships allowing a quick determination of the dimensional characteristics of the proposed winding.
We consider the case of three-phase distributed winding, with one slot per pole and per phase (q = 1), and star connection.
The proposed relationships depend on whether the number of pole pairs, p, is even or odd. To facilitate the determination of these relationships, we consider the developed winding layout shown in Figure 4(a) (p is even: 4p, 24 s) and Figure 4(b) (p is odd: 5p, 30s).
Developed winding layout, for two different cases: 4p/24 s and 5p/30s. (a)
According to the Figure 4, we can clearly note the different lengths of bars stated earlier in the previous section: short bar (bow/bow), medium bar (bow/crook), and long bar (crook/crook). We also note that if p is even the connection of the neutral is ensured by an “bow bar” and “crook bar”, whereas if p is odd the connection of the neutral is performed with two “bow bars”.
If
Otherwise, if
The sum of the different bars must satisfy this relationship:
where
One of the main advantages of the proposed bar winding, with respect to the conventional round wire winding, is that the end-winding copper volume can be accurately estimated from the machine’s basic parameters (conductor height/width, slot number etc.).
All the machine’s dimensions necessary to calculate the total length of the copper as well as the end-winding ratio are illustrated in the Figure 5.
Geometrical parameters of the proposed solid bar winding. (a) Front view. (b) Longitudinal section view.
The total volume of the winding copper,
The end-winding copper is the sum of the bent connection bars (bow and crook) and the part of the bars located in the slots which overhangs the stator magnetic core.
Hence,
where
If p is even:
Otherwise, if p is odd:
We may express the total volume of the winding copper,
The end-winding ratio,
Relation 15 gives an idea about the copper wasted in the end-winding which is inactive because it does not participate in the creation of the torque. The lower is
Once the section of the conductor is known as well as the total length of the copper (cf. calculation in the previous section), the DC Joule loss can be accurately estimated from the following relation:
where
The solid copper conductor is always prone to supplementary loss called AC copper loss. This topic is treated in the next section.
A solid conductor is very favorable to additional losses due to the eddy-currents and circulating currents. Special attention must be paid to the bar design according to the frequency, otherwise the AC electrical resistance could increase tremendously. The cross-section area of the conductor is then restricted in the solid bar winding, which is a drawback. This problem does not arise for round wire winding where the use of stranded, insulated, and twisted wires (Litz wire) enable to overcome this limitation.
Three different phenomena could contribute to increase the loss in a solid conductor of electrical machines: the skin effect, the slot leakage flux, and the rotating field. A three-dimensional illustration of these effects is given in the Figure 6.
3D representation of the magnetic fields and their associated eddy-currents in a solid bar winding.
It is the well-known effect that tends to concentrate the current at the periphery of the conductor, this in an increasingly way as the frequency increases. The skin effect is due to opposing eddy-currents induced by the varying magnetic field,
The Figure 7 illustrates the skin effect in a solid copper bar with a cross-sectional area of 4x12 mm2 and carrying an alternative current at 550 Hz.
Skin effect in a rectangular solid bar.
The resistance factor,
where
For a better use of the copper area, the goal is always to obtain
The pure skin effect only concerns the end-windings, which is the part of the copper in the air.
For example, at f = 1000 Hz,
The slot leakage flux could create an extra copper loss in solid conductors surrounded by a magnetic material. This is an old phenomenon that was treated on large alternators and frequently called Field effect.
Indeed, the alternating leakage field due to the armature current, represented by
The Figure 8 shows 2D and 3D illustrations of the irregular current distribution in a solid copper bar surrounded by a magnetic material, with a cross-sectional area of 4x12 mm2 and carrying an alternative current at 550 Hz.
Non-uniform distribution of the current density in a solid conductor surrounded by a magnetic material. 2D FEA analysis (top) and 3D FEA analysis (bottom).
This same leakage flux effect is usefully exploited in double cage asynchronous machine to enhance the starting torque.
The resistance ratio,
where
It must be pointed out that the relation 18 is valid for simple layer winding (one bar per slot), which corresponds to the winding we are proposing here. Otherwise, a second term must be added in the relation 18 to take into account the proximity effect between the different elementary layers.
For a given width and frequency, a solid conductor surrounded by a magnetic material has an optimum height called
For the sake of illustrating what has been said above, we performed a 2D finite element calculation of the AC Joule loss in a copper bar with: fixed width of 4 mm, variable height between 1 mm and 20mm, a length of 1 m, carrying an alternating current of 285 Arms, and with parameterized frequency between 50 Hz and 1000 Hz. The results are presented on the Figure 9; we notice that there is an optimal height where the additional losses are minimal (minimum AC resistance) and which decreases with the frequency.
AC copper loss at 20°C in a rectangular solid bar with wbar = 4mm– Illustration of the critic height of the bar: Finite element analysis (left) and analytical relationship (21) (right).
The hcritic can be defined by the following relationship [6]:
Where δ is the skin depth of the bar, δ = 1/
The hcritic calculated by the relationship (21), for the same bar width wbar = 4 mm, is presented in the Figure 9(b), it can be shown that the analytical calculation is in good general agreement with the finite element analysis in the Figure 9(a).
As a rule of thumb, at 1 kHz operating frequency, at copper operating temperature around 150°C, the optimum copper bar height is around 4 mm.
To overcome the phenomenon of the uneven distribution of the current density due to the slot leakage flux, the most famous technique consists in subdividing the stator bars into parallel layers insulated from each other and regularly transposed along the length, so that each elementary conductor occupies different positions in the slot from the root to the head of the slot. With this technique the slot root inductance and the slot head inductance are balanced and the current tends to flow over the entire copper cross-sectional area. Consequently, the extra loss is tremendously mitigated and getting closer to the ohmic loss (DC loss). This technique is complex and impairs the copper fill factor compared to undivided bar due to the multiple insulations between the elementary conductors. It is commonly used for large generators (> 100MW rating) and called “
Using insulated conductors with simple paralleling (without twisting) is not sufficient to reduce losses, because the bars create circulating currents between each other, resulting in additional losses identical to those produced in an equivalent solid bar. The 2D finite element simulation in Figure 10 shows that the current density distribution in the parallel insulated conductors is the same with respect to a one solid bar (concentration near the slot opening).
Current density distribution in a copper bar following a simple paralleling.
However, the subdivision of the bar into
In lesser extent, there is a third effect caused by the rotor field traveling in front of the stator which is represented by Bmag in Figure 6. In this case, it is the rotating magnetic field of the permanent magnet mounted on the surface of the rotor. The variable Bmag could be seen by the solid conductors and, consequently, creates an extra eddy-current loss [1]. This loss component mainly depends on the slot opening and the saturation level of the iron surrounding the bar. If the slot is close enough the flux will be canalized by the iron and does not cross the copper. The typical slot opening width of the solid bar winding that we propose in this paper is between 0.5 and 1 mm (bar slipped into the slot). A finite element analysis, carried out on two different PM motors, has proven that the induced loss due to the rotating field is negligible for the slot opening lower than 2 mm, the results are shown in Figure 11.
Eddy-current loss in a solid bar due to the rotating field.
Many motor using the solid bar winding developed here were manufactured and tested successfully; all these motors were dedicated to the electric propulsion (e-Cars, e-Boats,…).
The main characteristics of one of these motor are presented in the Table 2. The stator and rotor photos are presented in the Figure 12.
Dimensions | |
---|---|
Stator outer diameter | 180 mm |
Stator inner diameter | 140 mm |
Magnetic airgap | 1,5 mm |
Magent height | 6.1 mm |
Stator stack length | 50 mm |
Winding bar dimensions (hxw) | 6x4 mm |
Slot dimensions (hxw) | 7x5 mm |
Stator corepack | M270-35A |
Magnets | N35UH |
Pole number | 16 |
Slot number | 48 |
Phase resistance, 20°C - 100°C | 1,3 mΩ - 1,7 mΩ |
Phase inductance | 12 μH |
Back EMF coefficient ke | 41,1 mVs/rd |
Torque coefficient kt | 0,123 Nm/A |
Total weight (including mechanics) | 10 kg |
Nominal torque-to-weight ratio | 2.5 Nm/kg |
Cooling | Natural convection |
Motor characteristics.
Photo of the prototype. Left: Standalone wound stator with bar winding - Right: Glued magnets on the rotor wheel and sleeved rotor.
The first test was carried out at no load by driving the motor with another machine. The line to line back EMF was measured and showed a good agreement with the predicted back EMF via the commercial FEA tool ANSYS Maxwell (cf. Figure 13).
Line to line back EMF at 3700 rpm and at 80°C magnet temperature.
The electrical power at the input of the inverter driving the motor at no load was measured as well, this measurement represents the total no load losses of the motor. At 3700 rpm, the total no load losses are equal to 300 W, cf. Table 3.
(1) | Phase current [Arms] | 170 |
(2) | Copper temperature [°C] | 100 |
(3) | Speed [rpm] | 3700 |
(4) | Frequency [Hz] | 493.33 |
(5) | Torque [Nm] | 20 |
(6) | Total phase resistance - Measured [mOhms] | 1.7 |
(7) | Total phase resistance - copper in slots only [mOhms] | 0.739 |
(8) | Total phase resistance - copper the end-windings only [(6)–(7)] [mOhms] | 0.961 |
(9) | DC copper loss at end-windings only [W] | 83.36 |
(10) | DC copper loss in the slots only [W] | 64.03 |
(11) | Kleak relationship 18 in Section 4.2.1 | 1.59 |
(12) | AC copper loss in the slots only - Analytical prediction [(11) x (9)] [W] | 101.81 |
(13) | AC copper loss in the slots only - 2D FEA Ansys Maxwell [W] | 93 |
(14) | Total no load losses - Measured (no load core loss + mechanical losses) [W] | 300 |
(15) | Magnet eddy-current loss - 2D FEA Ansys Maxwell [W] | 1.4 |
(16) | Sleeve eddy-current loss (non conductive) [W] | 0 |
(17) | Motor electrical input power - Measured [W] | 8270 |
(18) | Motor mechanical output power - Measured [W] | 7750 |
(19) | Motor total on load losses - Measured [(17)–(18)] [W] | 520.00 |
(20) | Total additional losses [(19)–(15) - (14) - (13) - (9)] [W] | 42.24 |
(21) | Efficiency of the motor - Measured [%] | 93.712 |
Motor losses breakdown.
Afterwards, a test rig was set up in back-to-back configuration (two identical motors) for the full load testing, as shown in Figure 14. The electrical power was measured at the output of the inverter driving one of the two motors by consuming the electrical power from the battery rack. The winding of the second motor is generating the power to charge the same battery. The output mechanical power was measured via a torque meter installed between the two motors.
Photo of the test rig – The identical motors are connected in back-to-back configuration.
The flux density and the full load torque were checked with ANSYS Maxwell and presented in the Figures 15 and 16 respectively.
On load flux density obtained from FEA analysis (ANSYS Maxwell) at 170 arms/20 nm.
Electromagnetic torque calculated by FEA at 170 Arms and 80°C magnet temperature.
The extra on load losses dissipated in the motor were isolated based on the measurements and the AC copper losses predicted by means of the FEA analysis; the calculation is detailed in the Table 3. These extra losses present 8% of the total on load losses (42 W/520 W), they occur in any inverter fed electric motors and can be split into many components:
The additional core loss due to the polluted current injected by the inverter.
The extra AC copper loss due to the distorted current from the inverter (switching harmonics).
Stray losses: these regroup all the “non-conventional” losses such as the eddy-current losses in the metallic structure of the motor (e.g. the end-windings leakage flux can generate eddy-currents in the flanges…).
The different tests carried out have shown that the motor is able to reaches the required performance point of view output power, efficiency and thermal behavior. The total losses were proven to be at the predicted level.
As the general surgical techniques have polished with more and more precise gestures, which in time lead to the appearance and development of even robotic surgery, the same phenomenon happened when it comes to adjuvant methods to better identify, visualize, and resect a specific structure/tissue during the intervention. Fluorescence can bring important assets when it comes to seeing better—the vessels, the lymph nodes, and the tumor itself. Some organs, such as the case of the ureter, are also much better underlined with the technique of NIR-ICG (near-infrared light and indocyanine green [ICG]), and therefore, the risk of producing a lesion secondary to incomplete visualization is smaller. This chapter closely looks at the literature on the theme of ICG in colorectal surgery, offering also a general frame made out of significant research, mainly systematic reviews and randomized controlled trials about the use of ICG in visceral surgery.
According to the definition given by the Merriam-Webster dictionary, a dye or a stain is able to penetrate living cells or tissues without inducing immediate obvious degenerative changes and thus, it is also called a vital stain. Supravital staining implies the removal of living cells from an organism, whereas intravital staining involves injecting (or otherwise administering) the dye into the organism. The term “vital stain” is sometimes used to refer to an intravital stain, and in some other situations, it is interchangeable with a supravital stain, the main idea being that the cell being looked at is still alive. In a more strict way of speaking, the term “vital staining” has a meaning which is opposite to “supravital staining.” If living cells take up the stain during supravital staining, living cells exclude the dye during “vital staining”; for example, they color negatively and only dead cells color positively, and hence, viability can be measured by counting in percentage the amount of total cells that stain negatively. Because the nature of the dye defines if the staining is either supravital or intravital, a mix of supravital and vital dyes can be employed to better categorize cells into various groups (e.g., viable, dead, dying) (Figures 1 and 2).
Metallic green sheen characteristic colonies of
A vial of methylene blue.
Tissue staining, also known as chromoscopy, can be used as an adjuvant technique in gastrointestinal endoscopy to help with the recognition of subtle lesions, such as is the case with polyps or, more so, allows to directly target biopsies, which may happen in the case of Barrett’s esophagus, in order to increase the precision of the diagnosis. Four endoscopic staining techniques have been described—vital staining (the use of an agent that is absorbed by the intestinal epithelium), contrast staining (the use of a substance to accentuate the aspect of the surface), reactive staining (the use of an agent that can fire chemical reactions), and tattooing (a technique using agents such as India ink to underline a special lesion on the mucosa).
Tissue stains used in gastrointestinal surgery, as mentioned by Fennerty [1], can be classified as follows:
tattooing agents
India ink is used for permanent marking of the mucosal site for relocalization at the time of surgery or endoscopy, also used in the esophagus, stomach, and colon, which is safe without side effects.
Indocyanine green is a shorter-duration tattooing agent with more information offered in the following section.
absorptive stains
Lugol’s iodine (stains normal glycogen containing squamous mucosa of the esophagus, allowing recognition of abnormal squamous epithelium—dysplasia—or metaplastic epithelium—Barrett s esophagus),
methylene blue and toluidine blue (stains the absorptive epithelium small bowel and colon), allowing the identification of metaplastic epithelium in the esophagus (Barrett s esophagus) and stomach (gastric intestinal metaplasia), can also find a negative stain in gastric metaplasia at the level of the duodenal bulb.
contrast stains
indigo carmine and cresyl violet (accentuates mucosal topography, allowing recognition of abnormal small bowel sprue and colonic mucosa inflammatory bowel disease, polyps).
reactive stains
Congo red (identifies acid-secreting portions of the stomach postoperatively and documents achlorhydria) and
phenol red (identifies alkaline areas of the stomach).
According to the definition offered by www.britannica.com, fluorescence is the emission of electromagnetic radiation, usually visible light, caused by the excitation of atoms in a material, which then reemit almost immediately (within about 10 s). The initial excitation is frequently determined by the absorption of energy from incident radiation of particles, as is the case with X-rays or electrons (Figure 3). Due to the fact that reemission happens so quickly, the fluorescence stops when the exciting source is removed, unlike the phenomenon of phosphorescence (Figure 4), which later persists as an afterglow.
High-resolution fluorescent microscope image of clusters of tumor cells in red surrounded by normal cells and normal skin in green. Photo source:
Research sample slide of tumor tissue where cells have been stained for different proteins using a fluorescently tagged antibody. Presented as false-color image on white background.
Fluorescence imaging techniques have become increasingly common in recent years. ICG-based fluorescence, in particular, is now widely used in a variety of diagnostic and treatment procedures, according to the research made by Nowaka and co [2]. ICG is currently the most commonly used fluorescent agent due to its gradual degradation and the rarity of the severe adverse effects described. ICG is a water-soluble, amphiphilic tricarbocyanine probe with a molecular weight of 776 Da, relatively nontoxic, unstable compound, a dye in clinic use bound by albumin in the intravascular space until rapid clearance by the liver. Severe allergic reactions associated with the use of ICG are very rare (1:10,000) with an incidence of 0.05% and mostly occur in patients allergic to iodine. It has various applications in different fields, such as cardiology, ophthalmology, and neurosurgery, but its fluorescent properties have only recently been applied to the intraoperative estimation of tissue blood supply. Apart from ICG, other substances can act as fluorophores (fluorescent chemical compounds that are able to reemit light upon light excitation), such as methylene blue, five-aminolevulinic acid, fluorescein sodium.
What is fluorescence-guided surgery (FSG)? FSG is employed because white visible light makes various tissues appear either identical or highly similar, and proper tumor identification can be difficult, according to www.isfgs.org [3]. Moreover, the surgeon just sees the tissues from the superficial layers under natural light. Nonetheless, structures that were previously invisible can be seen now and recognized by using ICG in a different light length. By combining visual abilities with special dyes, it is now possible to avoid such organs or structures during the surgical process in order to avoid harming them. Other benefits of the FSG include the ability to minimize operative time and the need for second-look procedures by facilitating the rapid detection of structures and lesions while avoiding excessive harm.
ICG has found application in several fields of general surgery, especially colorectal surgery (seen in the next section of the present article), esophageal surgery, and emergency evaluation of intestinal perfusion in cases of mesenteric ischemia, kidney transplantation, hepatobiliary, and endocrine surgery.
ICG can improve the harvesting of tumors during surgery and can properly adjust both the indications, as the extent of the intervention. In a systematic review performed in 2020 by Baiocchi [4], which took into account 192 screened papers with six series meeting the eligibility criteria, there were analyzed in total 353 peritoneal nodules, the neoplasms in question being—colorectal, hepatocellular, ovarian, endometrial. The above-mentioned study had as a purpose to look at the available clinical data regarding the value of ICG fluorescence imaging for intraoperative detection of peritoneal carcinomatosis during open surgery and the main aspects studied settled to the conclusion that sensitivity varied from 72.4 to 100%, while the specificity ranged from 54.2 to 100%.
The ICG fluorescence method is being used more and more in liver surgery due to the fact that it permits the real-time display of the segmental anatomy of the organ, depending on the tumor’s characteristics, and, more so, it is possible to perform direct or indirect identification of hepatic lesions and metastases. Additionally, ICG imaging allows more sensitive detection of tumor foci and, therefore, also a higher R0 resection rate. However, in a systematic review of the literature on the application of ICG imaging in open and laparoscopic liver surgery performed by Sucher et al. [5], the conclusion was drawn toward the aspect that the application resulted mainly useful for superficial lesions, as the depth of penetration of NIR is only 8–10 mm. In liver resections, post-hepatectomy liver failure (PHLF) can occur although an adequate liver volume is kept in place. Diverse dynamic functional tests, such as the indocyanine green test (ICG), could only appreciate globally the liver function, with no definition toward the functional ability of the hepatic remnant. Magnetic resonance imaging (MRI) with liver-specific contrast agents makes the evaluation of both liver function and volume possible. A preoperative combination between dynamic quantitative tests, such as ICG, with MRI or HBS (hepato-bilio-scintigraphy), should provide a more complete functional evaluation. One should opt for various functional tests to predict PHLF that should be selected according to patient’s characteristics, disease, and center experience, as shown by Tomassini and the team [6].
The incidence of skin flap necrosis after mastectomies can reach 11–24%. Laser-assisted ICG angiography appears as a promising technique to assess skin flap perfusion. In a systematic review performed by Driessen et al. [7], it was found that all studies looking at the current ICG methodology and ability to predict outcome showed a substantial decrease in skin necrosis when the ICG was used.
Endometriosis is a very commonly encountered disease that is found in up to 10% of the female population. The use of (ICG) has been advocated for the proper location of endometriotic lesions intraoperatively. NIR-ICG is useful in appreciating the blood supply of bowel anastomoses after segmental resection, according to a systematic review done by Ianieri et al. [8] that looked at 53 studies.
Iatrogenic ureteral injury in abdominal surgery is rare at the moment, although it can still result in significant morbidity and mortality. Inspection and palpation are two traditional methods of measuring iatrogenic ureteral damage, which can be difficult during laparoscopic procedures. The use of NIRF imaging to aid in better visualization of the ureters is currently being investigated. The report’s goal performed by Slooter et al. [9] was to picture the currently available and experimental dyes in ureter visualization and to further evaluate their feasibility of using them and, more so, to look at their effectiveness.
Several studies, among which the one performed by Copaescu [10], aimed to look at the reliability of a novel fluorescence-guided laparoscopic technique to correctly find the site of unknown gastrointestinal bleeding, with the help of the vascular washout properties of indocyanine green (ICG). The bleeding site was correctly identified and the patient benefited from a minimally invasive technique, and it was, therefore, possible to avoid an open surgical exploration.
This represents another important topic in different surgical fields, for instance, urology, gynecology, and general surgery.
In the early stage of breast cancer, ICG-fluorescence-based sentinel lymph node (SLN) detection is being considered. A systematic review looking at 2301 patients from 19 studies found that ICG-fluorescence could complement the radioisotope method or provide an alternative. Another study regarding the ICG lymph node technique in breast cancer was a literature review presented by Benson [11] in which a significantly better sentinel node detection rate was found with ICG than with the standard radioisotope method (Figure 5).
The surgeon uses a portable fluorescence imaging device during breast removal. Photo source:
Techniques that combine the ability to identify technetium-99 and a blue dye have been widely used for sentinel lymph node biopsy (SLNB), but there has recently been a surge of interest in the use of fluorescent staining, such as indocyanine green (ICG), to improve the rate of SLN detection. Even though recent guidelines recommend sentinel lymph node biopsy in addition to PLND, SLN biopsy alone is not yet the gold standard because there is insufficient prospective evidence, especially in terms of long-term oncological protection. The prospective randomized clinical trial SENTICOL III will answer to these signaled issues, as a study by Balaya et al. [12] mentions. In addition to the facts mentioned above, the prospectively randomized FILM trial evaluated ICG to be superior in lymph node detection compared to isosulfan blue dye in patients with stage I endometrial or cervical cancer, an evaluation performed by Frumovitz and team [13]. Meanwhile, the study’s conclusions created a context for the FDA’s approval of ICG for lymph node mapping. NCCN guidelines mention sentinel lymph node mapping by ICG in cervical cancer patients, according to Koh et al. [14].
Anastomotic leakage remains among the most feared and challenging complications after colorectal resection. The etiology of leaks includes patient factors, technical factors, and anastomotic perfusion. The known etiology of leaks includes the following: different patient factors, technical factors, and anastomotic blood supply. An intact anastomotic irrigation pattern is particularly vital in the process of anastomotic healing. The air leak testing and intraoperative colonoscopy are methods that can be done to establish the anastomotic integrity intraoperatively. Among the major causes of anastomotic leakage is impaired vascularization and a minimal deficit in blood supply, both aspects being difficult to detect under white light. Fluorescence angiography with indocyanine green (ICG-FA) is employed in colorectal surgery in order to evaluate the blood supply in the area of an anastomosis. Studies with ICG-FA in open and laparoscopic interventions indicated a lower rate of anastomotic leakage; for example, the PILLAR II study reported a leakage rate of 1.4%. There were researches in this field, such as is the case of Carus and Pick [15] that reported impressive results in clinical outcome and patient prognosis. Likewise, the use of ICG-FA in the group of patients studied potentially led to a reduction of the leakage rate by 48%. Another systematic review from Blanco-Colino and Espin-Basany [16] looks at 1302 patients from five nonrandomized studies in which fluorescence imaging significantly decreased the anastomotic leak in cases operated on for colorectal cancer. Lower leak rates were found in rectal cancer surgery, as well (ICG 1.1% vs. non-ICG 6.1%; p = 0.02) (Figure 6).
X-ray angiography of the inferior mesenteric artery (IMA) with contrast media. Its supplies arterial blood to organs of hindgut-distal 1/3 of the transverse, splenic flexure, descending colon, sigmoid, rectum.
Indocyanine green fluorescence imaging can also be used as a potential tool for enhancing the accuracy of the staging of patients with primary colorectal cancer through the detection of sentinel lymph nodes. The search in electronic databases was performed and eligible data were taken from 248 patients in a review published by Emile et al. [17], which looked at the overall sensitivity and specificity of (ICG) (NIR) fluorescence in sentinel lymph node detection in colorectal cancer. The median values for the sensitivity, specificity, and accuracy rates were 73.7, 100, and 75.7, respectively. Other several studies, even though none was a prospective one, considered the ICG method feasible in colorectal cancer and also for lower rectal tumors, especially in order to detect the lymphatic drainage across the lateral lymph nodes, as studied by the teams of Nagata et al. [18], Kawahara et al. [19], Cahill et al. [20], and Liberale et al. [21]. Another method used in correctly and precisely identifying the lymph node involvement is one-step nucleic acid (OSNA), as it can offer a quick method of characterization of the lymph nodes. On the other hand, near-infrared (NIR) laparoscopy, together with indocyanine green (ICG), can identify relevant nodal tissue
A study performed by Vuijk et al. [23] looking at the lymph node involvement in gastrointestinal tumors assessed the sentinel lymph node technique with Nanocoll, and ICG- and CEA-targeted fluorescent imaging, and settled to the following conclusions: sentinel lymph node interventions in gastric cancer resections using indocyanine green (ICG) linked to Nanocoll outperformed normal ICG, but could not offer details on possible lymph node metastasis. Besides that aspect, the carcinoembryonic antigen (CEA)-targeted fluorescent imaging technique by using SGM-101 was successful in both pancreatic and colorectal cancers. A large phase III multicenter trial with the corresponding results would be able to complete the missing data.
Simultaneously, in which concerns lymph node invasion, the concept of ultrastaging appeared recently in the specific literature. Furthermore, studies were compiled, such as the one by Hirche et al. [24], in which regards ultrastaging of colon cancer by sentinel node biopsy using fluorescence navigation with ICG Overall, the ICG fluorescence technique found a mean of 1.7 sentinel lymph node (SLN) in 25 out of 26 patients (with a detection rate of 96%). Metastatic involvement of the SLN was detected in 9 out of 11 nodal positive patients by conventional histopathology. The sensitivity of the method was 82% in the case of colon carcinoma. The drawn conclusion of the abovementioned study was that the ICG fluorescence technique is a new but feasible method for SLNB of colon carcinoma and permits ultrastaging with improved accuracy, but with limited validity (so far) due to the small number of cases (Figures 7 and 8).
Colorectal cancer concept. Development of cancer from the colon or rectum to the whole large intestine. Stages of spreading tumor to the lymph nodes and vector flat illustration of other internal organs.
Metastatic colon carcinoma, in lymph node. Tumor component is on the left and lymphoid component is on the right, magnification 200×.
ICG is metabolized by the liver and accumulates in areas of slower bile metabolism, a situation that can be encountered in primary liver cancers and colorectal secondary determinations (metastases), as found by the teams of Peloso et al. [25] and van der Vorst [26]. A tumor cluster of cells as small as 200 tumor cells can be identified by ICG, allowing surgeons to find foci of a minimum of 1 mm, as it was shown by Ishizawa et al. [27]. The practical aspect of finding liver masses is that they have to be superficial, and the fluorescence methods can look at the maximum depth of infiltration of up to 10 mm. A combination of the application of intraoperative ultrasound and fluorescence techniques was shown to increase the identification rate of colorectal metastatic lesions, as it was researched by Kaibori et al. [28]. In patients suffering from liver fibrosis, nevertheless, areas that have a slow bile metabolism might give false-positive fluorescence. ICG fluorescence can be employed to qualitatively and quantitatively depict changes at a molecular and cellular level in the living organism, and to objectively display liver tumor information, to define hepatic tumor boundaries, and to detect residual tumors, achieving an intraoperative real time coloration and the successful navigation of the liver parenchyma in the targeted zone, as mentioned by Shizawa et al. [29]. A recent meta-analysis included studies on 587 patients showing that ICG fluorescence in the field of liver surgery does decrease operative time, blood loss, hospital stay, and postoperative complications if we are to mention a study done by Qi et al. [30]. As mentioned in subchapter 3.2.2 (ICG in liver surgery), the ICG fluorescence technique is for sure viewed as an intraoperative method that allows the detection of additional superficial hepatic metastases of colorectal cancer, a fact underlined by Liberale and team [31] in an article in which PubMed and Medline literature databases were searched for articles on the use of ICG in the setting of clinical studies on CRC (Figures 9 and 10).
Immunofluorescence of multiple human tumor metastatic cells growing in tissue culture for research purposes.
Human liver cancer cell growth. 3D illustration.
As previously shown in the previous subsections of the chapter, ICG fluorescence imaging is increasingly being used, tested, and documented in different areas of abdominal surgery. The constant improvement in the method and in the technological possibilities enables easy use and facilitates operative decision-making, also in robotically assisted colorectal surgery, as it is communicated in a study published by Vilz et al. [32]. Additional information offered there was that the first individual studies underlined an important reduction in the incidence of anastomotic leakage after colorectal anastomosis through the use of ICG fluorescence angiography (FA, 9.1% vs. 16.3%; p = 0.04). First feasibility research studies also emphasized lymph node detection or navigation, as well as the possibility to visualize the ureter (Figure 11).
Robotic surgery in the operation room.
In regard to tumor localization, ICG-coated endoscopic clips can bring a promising new technique, as seen in a study by Lee et al. [33]. The precise localization of a tumor before surgery is vital, more so in the early stages of cancer, and the amplitude of the surgical intervention must be established. The accurate localization of a colorectal lesion ensures proper margins for resection and prevents surgical removal of healthy segments of the colon; furthermore, it can reduce the duration of surgery and prevent unnecessary colon traction and tumor handling, which could result in dissemination of tumor cells. The method abovementioned involves placing endoscopic clips coated or mounted with near-infrared fluorescent material, such as ICG, at the lesion site and determining the location of the tumor by consequently detecting the fluorescent signal through the intestinal wall (through the use of a near-infrared laparoscope).
In a research by de Nardi and team [34], a randomized trial was formulated, involving 252 cases in which laparoscopic left-sided colon and rectal resection were performed. The algorithm randomized 1:1 to intraoperative ICG or to subjective visual evaluation of the bowel blood supply without ICG. The main results were the following: ICG angiography documented insufficient blood supply of the colic stump, which implied extended bowel resection in 13 cases (11%). In the control group, 11 patients (9%) had a fistula; meanwhile, in the study group, six patients (5%) developed one anastomotic leak (p = n.s.).
Based on the general elements reviewed, it was summed up that intraoperative ICG fluorescence angiography can efficiently find correctly the vasculature of the colic stump and anastomosis in situations when colorectal resection is performed.
Despite the fact that this method guided proximal bowel resection in 13 instances, the ICG arm did not find a statistically meaningful decrease in anastomotic bowel leak rate. Transanal ICG angiography has been shown to be both feasible and effective in imaging the mucosal and anastomotic blood supply in research conducted by Sherwinter [35]. Future research in a larger community of patients is needed to fully understand the technique’s potential to detect flaws in tissue perfusion that could lead to an anastomotic breakdown. Twenty patients with benign and malignant lesions underwent low anterior resection for the analysis. Indocyanine green (ICG) was injected through a peripheral iv catheter after the anastomosis was completed. Transanally, an endoscopic near-infrared imaging device (NIR) was used to test the blood supply at the level of the colon mucosa, the rectum, and the anastomotic staple axis (Figure 12).
Schematics of fluorescence angiography in the colorectal area.
The incidence of the incisional surgical site infections in colorectal surgery was reported between 5 and 26%. Surgical site infections (SSI) in an abdominoperineal resection (APR) appear more than in other types of interventions in the case of patients with colorectal cancer. Toshiyuki et al. [36] found that perineal wounds are the most vulnerable sites, and they may be triggered by stool contamination. Indocyanine green (ICG) fluorescence testing was employed as a marker of perineal wound contamination. The study had as a method to inject indocyanine green into the rectum transanally before the operation, and fluorescence images were obtained during the operation in patients who underwent APR. The findings, though sparse, are promising: one subject had an SSI after having no clear gross contamination, and a trace of ICG fluorescence was found in the perianal skin.
The other two cases were free of SSI, and skin treatment was carried out thoroughly before ICG contamination was removed in those cases.
Even after the normal antiseptic skin preparation, a trace of stool contamination can remain in the perineal skin area, according to the study’s findings.
Furthermore, careful skin preparation is needed and it is compulsory if we are to minimize stool contamination in APR subjects (Figure 13).
A perineal wound with infection and inflammation after colorectal surgery.
India ink has been largely used for preoperative colonic tattooing, but different complications have been reported. A study performed by Miyoshi et al. [37] looked at the surgical usefulness of ICG as an alternative to India ink for endoscopic marking and evaluated 40 patients between the time of ICG marking and the intervention, the median time period was 4 days (range, 1–73 days).
At the time of surgery, all 29 patients who were operated on within 8 days of tattooing stained positive in green with ICG dye.
Positive staining was clearly obviated in just two of the remaining 10 cases after 9 days or more.
The staining faded over time and finally vanished.
There was no mention of the dye’s perioperative side effects.
The authors concluded that this study supports the use of ICG as a safe approach that may be consistently detected within 8 days of endoscopic injection (Figure 14).
Colon polyp removal. Endoscope inside colonoscopy for colon polyps.
Efficacy of oral or rectal administration of indocyanine green solution. In a study realized by Sou et al. [38] whose objectives were to detect enterovesical occult microfistulas in patients with Crohn’s disease before the fistulas had become readily apparent, nonhazardous enteral administration of indocyanine green solution was performed. The methods that were used collected a total of 12 patients with Crohn’s disease who were suspected from their clinical manifestations of having enterovesical fistulas. Urine was collected and tested for contamination with indocyanine green by using a colorimeter to detect fistulas following oral or rectal administration of the indocyanine green solution. In addition, the efficacy of the indocyanine green test was compared to that of the “classical” X-ray sample.
The ICG test was positive in 11 of the 12 cases after either oral or rectal administration, resulting in a 92% correct diagnosis rate (11/12 patients).
The percentage of right diagnoses using an X-ray analysis, on the other hand, was just 17% (2/12 patients).
Furthermore, none of the eight patients with secret fistulas could be accurately diagnosed using an X-ray analysis, but all showed promising results when the indocyanine green approach was used.
The researchers concluded that the indocyanine green test had a 92% accuracy rate in diagnosing obscure fistulas and was highly diagnostic, while traditional examinations are often complicated and inaccurate (Figure 15).
Intraoperative macroscopic enterovesical fistula.
Peritoneal metastases can appear in 30–40% of patients with colorectal cancer and in a quarter of the patients might be the cause of death. ICG-guided surgery was able to detect additional lesions, and some studies reported up to 21.4% with a direct impact on modifying the surgical resection technique (Figure 16).
Extensive lesions of peritoneal carcinomatosis.
Fluorescence-assisted surgery using near-infrared (NIR) light is a relatively new technique.
To improve the visible spectrum, this technique uses a combination of dyes and NIR imaging equipment.
As a result, it may provide more detailed anatomic and functional details, allowing for a more complete resection of a neoplasm or the protection of essential normal structures. Indocyanine green fluorescence technique is a surgical tool with increasing perioperative and intraoperative applications in colorectal surgical interventions. In colorectal surgery, in particular, several studies have shown that intraoperative fluorescence imaging is a safe and feasible method to evaluate anastomotic perfusion, and its use might positively affect the patient’s clinical outcome by decreasing the incidence of anastomotic leaks. The number of virtual uses for indocyanine green is enhancing and developing, including new ways to detect and control colorectal metastases to the liver. All these advances expanded by the further evolution in time with more prospective trials could offer great information and value for both surgeons and patients, by improving the accuracy and outcomes of general surgery and surgical oncology.
The author declares no conflict of interest.
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\n\nIntechOpen has collaborated with Enago, through its sister brand, Ulatus, which is one of the world’s leading providers of book translation services. The services are designed to convey the essence of your work to readers from across the globe in a language they understand. Enago’s expert translators incorporate cultural nuances in translations to make the content relevant for local audiences while retaining the original meaning and style. Enago translators are equipped to handle all complex and multiple overlapping themes encompassed in a single book and their high degree of linguistic and subject expertise enables them to deliver a superior quality output.
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\n\nFor a complete overview of all publishing process steps and descriptions, go to How Open Access Publishing Works.
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\n\nIf you are interested in publishing your book with IntechOpen, please submit your book proposal by completing the Publishing Proposal Form.
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Working with large volumes of data has given him a good command of big data processing tools and NoSQL databases. He has also been a visiting scholar at the Knowledge Engineering and Discovery Research Institute, Auckland University of Technology.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"314575",title:"Dr.",name:"Jesus",middleName:null,surname:"L. Lobo",slug:"jesus-l.-lobo",fullName:"Jesus L. Lobo",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/314575/images/system/314575.png",biography:"Dr. Jesús López is currently based in Bilbao (Spain) working at TECNALIA as Artificial Intelligence Research Scientist. In most cases, a project idea or a new research line needs to be investigated to see if it is good enough to take into production or to focus on it. That is exactly what he does, diving into Machine Learning algorithms and technologies to help TECNALIA to decide whether something is great in theory or will actually impact on the product or processes of its projects. So, he is expert at framing experiments, developing hypotheses, and proving whether they’re true or not, in order to investigate fundamental problems with a longer time horizon. He is also able to design and develop PoCs and system prototypes in simulation. He has participated in several national and internacional R&D projects.\n\nAs another relevant part of his everyday research work, he usually publishes his findings in reputed scientific refereed journals and international conferences, occasionally acting as reviewer and Programme Commitee member. Concretely, since 2018 he has published 9 JCR (8 Q1) journal papers, 9 conference papers (e.g. ECML PKDD 2021), and he has co-edited a book. He is also active in popular science writing data science stories for reputed blogs (KDNuggets, TowardsDataScience, Naukas). Besides, he has recently embarked on mentoring programmes as mentor, and has also worked as data science trainer.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"103779",title:"Prof.",name:"Yalcin",middleName:null,surname:"Isler",slug:"yalcin-isler",fullName:"Yalcin Isler",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRyQ8QAK/Profile_Picture_1628834958734",biography:"Yalcin Isler (1971 - Burdur / Turkey) received the B.Sc. degree in the Department of Electrical and Electronics Engineering from Anadolu University, Eskisehir, Turkey, in 1993, the M.Sc. degree from the Department of Electronics and Communication Engineering, Suleyman Demirel University, Isparta, Turkey, in 1996, the Ph.D. degree from the Department of Electrical and Electronics Engineering, Dokuz Eylul University, Izmir, Turkey, in 2009, and the Competence of Associate Professorship from the Turkish Interuniversity Council in 2019.\n\nHe was Lecturer at Burdur Vocational School in Suleyman Demirel University (1993-2000, Burdur / Turkey), Software Engineer (2000-2002, Izmir / Turkey), Research Assistant in Bulent Ecevit University (2002-2003, Zonguldak / Turkey), Research Assistant in Dokuz Eylul University (2003-2010, Izmir / Turkey), Assistant Professor at the Department of Electrical and Electronics Engineering in Bulent Ecevit University (2010-2012, Zonguldak / Turkey), Assistant Professor at the Department of Biomedical Engineering in Izmir Katip Celebi University (2012-2019, Izmir / Turkey). He is an Associate Professor at the Department of Biomedical Engineering at Izmir Katip Celebi University, Izmir / Turkey, since 2019. In addition to academics, he has also founded Islerya Medical and Information Technologies Company, Izmir / Turkey, since 2017.\n\nHis main research interests cover biomedical signal processing, pattern recognition, medical device design, programming, and embedded systems. He has many scientific papers and participated in several projects in these study fields. He was an IEEE Student Member (2009-2011) and IEEE Member (2011-2014) and has been IEEE Senior Member since 2014.",institutionString:null,institution:{name:"Izmir Kâtip Çelebi University",country:{name:"Turkey"}}},{id:"339677",title:"Dr.",name:"Mrinmoy",middleName:null,surname:"Roy",slug:"mrinmoy-roy",fullName:"Mrinmoy Roy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/339677/images/16768_n.jpg",biography:"An accomplished Sales & Marketing professional with 12 years of cross-functional experience in well-known organisations such as CIPLA, LUPIN, GLENMARK, ASTRAZENECA across different segment of Sales & Marketing, International Business, Institutional Business, Product Management, Strategic Marketing of HIV, Oncology, Derma, Respiratory, Anti-Diabetic, Nutraceutical & Stomatological Product Portfolio and Generic as well as Chronic Critical Care Portfolio. A First Class MBA in International Business & Strategic Marketing, B.Pharm, D.Pharm, Google Certified Digital Marketing Professional. Qualified PhD Candidate in Operations and Management with special focus on Artificial Intelligence and Machine Learning adoption, analysis and use in Healthcare, Hospital & Pharma Domain. Seasoned with diverse therapy area of Pharmaceutical Sales & Marketing ranging from generating revenue through generating prescriptions, launching new products, and making them big brands with continuous strategy execution at the Physician and Patients level. Moved from Sales to Marketing and Business Development for 3.5 years in South East Asian Market operating from Manila, Philippines. Came back to India and handled and developed Brands such as Gluconorm, Lupisulin, Supracal, Absolut Woman, Hemozink, Fabiflu (For COVID 19), and many more. In my previous assignment I used to develop and execute strategies on Sales & Marketing, Commercialization & Business Development for Institution and Corporate Hospital Business portfolio of Oncology Therapy Area for AstraZeneca Pharma India Ltd. Being a Research Scholar and Student of ‘Operations Research & Management: Artificial Intelligence’ I published several pioneer research papers and book chapters on the same in Internationally reputed journals and Books indexed in Scopus, Springer and Ei Compendex, Google Scholar etc. Currently, I am launching PGDM Pharmaceutical Management Program in IIHMR Bangalore and spearheading the course curriculum and structure of the same. I am interested in Collaboration for Healthcare Innovation, Pharma AI Innovation, Future trend in Marketing and Management with incubation on Healthcare, Healthcare IT startups, AI-ML Modelling and Healthcare Algorithm based training module development. I am also an affiliated member of the Institute of Management Consultant of India, looking forward to Healthcare, Healthcare IT and Innovation, Pharma and Hospital Management Consulting works.",institutionString:null,institution:{name:"Lovely Professional University",country:{name:"India"}}},{id:"1063",title:"Prof.",name:"Constantin",middleName:null,surname:"Volosencu",slug:"constantin-volosencu",fullName:"Constantin Volosencu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/1063/images/system/1063.png",biography:"Prof. Dr. Constantin Voloşencu graduated as an engineer from\nPolitehnica University of Timișoara, Romania, where he also\nobtained a doctorate degree. He is currently a full professor in\nthe Department of Automation and Applied Informatics at the\nsame university. Dr. Voloşencu is the author of ten books, seven\nbook chapters, and more than 160 papers published in journals\nand conference proceedings. He has also edited twelve books and\nhas twenty-seven patents to his name. He is a manager of research grants, editor in\nchief and member of international journal editorial boards, a former plenary speaker, a member of scientific committees, and chair at international conferences. His\nresearch is in the fields of control systems, control of electric drives, fuzzy control\nsystems, neural network applications, fault detection and diagnosis, sensor network\napplications, monitoring of distributed parameter systems, and power ultrasound\napplications. He has developed automation equipment for machine tools, spooling\nmachines, high-power ultrasound processes, and more.",institutionString:'"Politechnica" University Timişoara',institution:null},{id:"221364",title:"Dr.",name:"Eneko",middleName:null,surname:"Osaba",slug:"eneko-osaba",fullName:"Eneko Osaba",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/221364/images/system/221364.jpg",biography:"Dr. Eneko Osaba works at TECNALIA as a senior researcher. He obtained his Ph.D. in Artificial Intelligence in 2015. He has participated in more than twenty-five local and European research projects, and in the publication of more than 130 papers. He has performed several stays at universities in the United Kingdom, Italy, and Malta. Dr. Osaba has served as a program committee member in more than forty international conferences and participated in organizing activities in more than ten international conferences. He is a member of the editorial board of the International Journal of Artificial Intelligence, Data in Brief, and Journal of Advanced Transportation. He is also a guest editor for the Journal of Computational Science, Neurocomputing, Swarm, and Evolutionary Computation and IEEE ITS Magazine.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"275829",title:"Dr.",name:"Esther",middleName:null,surname:"Villar-Rodriguez",slug:"esther-villar-rodriguez",fullName:"Esther Villar-Rodriguez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/275829/images/system/275829.jpg",biography:"Dr. Esther Villar obtained a Ph.D. in Information and Communication Technologies from the University of Alcalá, Spain, in 2015. She obtained a degree in Computer Science from the University of Deusto, Spain, in 2010, and an MSc in Computer Languages and Systems from the National University of Distance Education, Spain, in 2012. Her areas of interest and knowledge include natural language processing (NLP), detection of impersonation in social networks, semantic web, and machine learning. Dr. Esther Villar made several contributions at conferences and publishing in various journals in those fields. Currently, she is working within the OPTIMA (Optimization Modeling & Analytics) business of TECNALIA’s ICT Division as a data scientist in projects related to the prediction and optimization of management and industrial processes (resource planning, energy efficiency, etc).",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"49813",title:"Dr.",name:"Javier",middleName:null,surname:"Del Ser",slug:"javier-del-ser",fullName:"Javier Del Ser",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49813/images/system/49813.png",biography:"Prof. Dr. Javier Del Ser received his first PhD in Telecommunication Engineering (Cum Laude) from the University of Navarra, Spain, in 2006, and a second PhD in Computational Intelligence (Summa Cum Laude) from the University of Alcala, Spain, in 2013. He is currently a principal researcher in data analytics and optimisation at TECNALIA (Spain), a visiting fellow at the Basque Center for Applied Mathematics (BCAM) and a part-time lecturer at the University of the Basque Country (UPV/EHU). His research interests gravitate on the use of descriptive, prescriptive and predictive algorithms for data mining and optimization in a diverse range of application fields such as Energy, Transport, Telecommunications, Health and Industry, among others. In these fields he has published more than 240 articles, co-supervised 8 Ph.D. theses, edited 6 books, coauthored 7 patents and participated/led more than 40 research projects. He is a Senior Member of the IEEE, and a recipient of the Biscay Talent prize for his academic career.",institutionString:"Tecnalia Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"278948",title:"Dr.",name:"Carlos Pedro",middleName:null,surname:"Gonçalves",slug:"carlos-pedro-goncalves",fullName:"Carlos Pedro Gonçalves",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRcmyQAC/Profile_Picture_1564224512145",biography:'Carlos Pedro Gonçalves (PhD) is an Associate Professor at Lusophone University of Humanities and Technologies and a researcher on Complexity Sciences, Quantum Technologies, Artificial Intelligence, Strategic Studies, Studies in Intelligence and Security, FinTech and Financial Risk Modeling. He is also a progammer with programming experience in:\n\nA) Quantum Computing using Qiskit Python module and IBM Quantum Experience Platform, with software developed on the simulation of Quantum Artificial Neural Networks and Quantum Cybersecurity;\n\nB) Artificial Intelligence and Machine learning programming in Python;\n\nC) Artificial Intelligence, Multiagent Systems Modeling and System Dynamics Modeling in Netlogo, with models developed in the areas of Chaos Theory, Econophysics, Artificial Intelligence, Classical and Quantum Complex Systems Science, with the Econophysics models having been cited worldwide and incorporated in PhD programs by different Universities.\n\nReceived an Arctic Code Vault Contributor status by GitHub, due to having developed open source software preserved in the \\"Arctic Code Vault\\" for future generations (https://archiveprogram.github.com/arctic-vault/), with the Strategy Analyzer A.I. module for decision making support (based on his PhD thesis, used in his Classes on Decision Making and in Strategic Intelligence Consulting Activities) and QNeural Python Quantum Neural Network simulator also preserved in the \\"Arctic Code Vault\\", for access to these software modules see: https://github.com/cpgoncalves. He is also a peer reviewer with outsanding review status from Elsevier journals, including Physica A, Neurocomputing and Engineering Applications of Artificial Intelligence. Science CV available at: https://www.cienciavitae.pt//pt/8E1C-A8B3-78C5 and ORCID: https://orcid.org/0000-0002-0298-3974',institutionString:"University of Lisbon",institution:{name:"Universidade Lusófona",country:{name:"Portugal"}}},{id:"310576",title:"Prof.",name:"Erick Giovani",middleName:null,surname:"Sperandio Nascimento",slug:"erick-giovani-sperandio-nascimento",fullName:"Erick Giovani Sperandio Nascimento",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0033Y00002pDKxDQAW/ProfilePicture%202022-06-20%2019%3A57%3A24.788",biography:"Prof. Erick Sperandio is the Lead Researcher and professor of Artificial Intelligence (AI) at SENAI CIMATEC, Bahia, Brazil, also working with Computational Modeling (CM) and HPC. He holds a PhD in Environmental Engineering in the area of Atmospheric Computational Modeling, a Master in Informatics in the field of Computational Intelligence and Graduated in Computer Science from UFES. He currently coordinates, leads and participates in R&D projects in the areas of AI, computational modeling and supercomputing applied to different areas such as Oil and Gas, Health, Advanced Manufacturing, Renewable Energies and Atmospheric Sciences, advising undergraduate, master's and doctoral students. He is the Lead Researcher at SENAI CIMATEC's Reference Center on Artificial Intelligence. In addition, he is a Certified Instructor and University Ambassador of the NVIDIA Deep Learning Institute (DLI) in the areas of Deep Learning, Computer Vision, Natural Language Processing and Recommender Systems, and Principal Investigator of the NVIDIA/CIMATEC AI Joint Lab, the first in Latin America within the NVIDIA AI Technology Center (NVAITC) worldwide program. He also works as a researcher at the Supercomputing Center for Industrial Innovation (CS2i) and at the SENAI Institute of Innovation for Automation (ISI Automação), both from SENAI CIMATEC. He is a member and vice-coordinator of the Basic Board of Scientific-Technological Advice and Evaluation, in the area of Innovation, of the Foundation for Research Support of the State of Bahia (FAPESB). He serves as Technology Transfer Coordinator and one of the Principal Investigators at the National Applied Research Center in Artificial Intelligence (CPA-IA) of SENAI CIMATEC, focusing on Industry, being one of the six CPA-IA in Brazil approved by MCTI / FAPESP / CGI.br. He also participates as one of the representatives of Brazil in the BRICS Innovation Collaboration Working Group on HPC, ICT and AI. He is the coordinator of the Work Group of the Axis 5 - Workforce and Training - of the Brazilian Strategy for Artificial Intelligence (EBIA), and member of the MCTI/EMBRAPII AI Innovation Network Training Committee. He is the coordinator, by SENAI CIMATEC, of the Artificial Intelligence Reference Network of the State of Bahia (REDE BAH.IA). He leads the working group of experts representing Brazil in the Global Partnership on Artificial Intelligence (GPAI), on the theme \"AI and the Pandemic Response\".",institutionString:null,institution:null},{id:"241400",title:"Prof.",name:"Mohammed",middleName:null,surname:"Bsiss",slug:"mohammed-bsiss",fullName:"Mohammed Bsiss",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/241400/images/8062_n.jpg",biography:null,institutionString:null,institution:null},{id:"276128",title:"Dr.",name:"Hira",middleName:null,surname:"Fatima",slug:"hira-fatima",fullName:"Hira Fatima",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/276128/images/14420_n.jpg",biography:"Dr. Hira Fatima\nAssistant Professor\nDepartment of Mathematics\nInstitute of Applied Science\nMangalayatan University, Aligarh\nMobile: no : 8532041179\nhirafatima2014@gmal.com\n\nDr. Hira Fatima has received his Ph.D. degree in pure Mathematics from Aligarh Muslim University, Aligarh India. Currently working as an Assistant Professor in the Department of Mathematics, Institute of Applied Science, Mangalayatan University, Aligarh. She taught so many courses of Mathematics of UG and PG level. Her research Area of Expertise is Functional Analysis & Sequence Spaces. She has been working on Ideal Convergence of double sequence. She has published 17 research papers in National and International Journals including Cogent Mathematics, Filomat, Journal of Intelligent and Fuzzy Systems, Advances in Difference Equations, Journal of Mathematical Analysis, Journal of Mathematical & Computer Science etc. She has also reviewed few research papers for the and international journals. She is a member of Indian Mathematical Society.",institutionString:null,institution:null},{id:"417317",title:"Mrs.",name:"Chiedza",middleName:null,surname:"Elvina Mashiri",slug:"chiedza-elvina-mashiri",fullName:"Chiedza Elvina Mashiri",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Midlands State University",country:{name:"Zimbabwe"}}},{id:"352140",title:"Dr.",name:"Edina",middleName:null,surname:"Chandiwana",slug:"edina-chandiwana",fullName:"Edina Chandiwana",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Midlands State University",country:{name:"Zimbabwe"}}},{id:"342259",title:"B.Sc.",name:"Leonard",middleName:null,surname:"Mushunje",slug:"leonard-mushunje",fullName:"Leonard Mushunje",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Midlands State University",country:{name:"Zimbabwe"}}},{id:"347042",title:"Mr.",name:"Maxwell",middleName:null,surname:"Mashasha",slug:"maxwell-mashasha",fullName:"Maxwell Mashasha",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Midlands State University",country:{name:"Zimbabwe"}}},{id:"2941",title:"Dr.",name:"Alberto J.",middleName:"Jorge",surname:"Rosales-Silva",slug:"alberto-j.-rosales-silva",fullName:"Alberto J. Rosales-Silva",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Instituto Politécnico Nacional",country:{name:"Mexico"}}},{id:"437913",title:"Dr.",name:"Guillermo",middleName:null,surname:"Urriolagoitia-Sosa",slug:"guillermo-urriolagoitia-sosa",fullName:"Guillermo Urriolagoitia-Sosa",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Instituto Politécnico Nacional",country:{name:"Mexico"}}},{id:"435126",title:"Prof.",name:"Joaquim",middleName:null,surname:"José de Castro Ferreira",slug:"joaquim-jose-de-castro-ferreira",fullName:"Joaquim José de Castro Ferreira",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Aveiro",country:{name:"Portugal"}}},{id:"437899",title:"MSc.",name:"Miguel Angel",middleName:null,surname:"Ángel Castillo-Martínez",slug:"miguel-angel-angel-castillo-martinez",fullName:"Miguel Angel Ángel Castillo-Martínez",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Instituto Politécnico Nacional",country:{name:"Mexico"}}},{id:"289955",title:"Dr.",name:"Raja",middleName:null,surname:"Kishor Duggirala",slug:"raja-kishor-duggirala",fullName:"Raja Kishor Duggirala",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Jawaharlal Nehru Technological University, Hyderabad",country:{name:"India"}}}]}},subseries:{item:{id:"10",type:"subseries",title:"Animal Physiology",keywords:"Physiology, Comparative, Evolution, Biomolecules, Organ, Homeostasis, Anatomy, Pathology, Medical, Cell Division, Cell Signaling, Cell Growth, Cell Metabolism, Endocrine, Neuroscience, Cardiovascular, Development, Aging, Development",scope:"Physiology, the scientific study of functions and mechanisms of living systems, is an essential area of research in its own right, but also in relation to medicine and health sciences. The scope of this topic will range from molecular, biochemical, cellular, and physiological processes in all animal species. Work pertaining to the whole organism, organ systems, individual organs and tissues, cells, and biomolecules will be included. Medical, animal, cell, and comparative physiology and allied fields such as anatomy, histology, and pathology with physiology links will be covered in this topic. Physiology research may be linked to development, aging, environment, regular and pathological processes, adaptation and evolution, exercise, or several other factors affecting, or involved with, animal physiology.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/10.jpg",hasOnlineFirst:!1,hasPublishedBooks:!1,annualVolume:11406,editor:{id:"202192",title:"Dr.",name:"Catrin",middleName:null,surname:"Rutland",slug:"catrin-rutland",fullName:"Catrin Rutland",profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",biography:"Catrin Rutland is an Associate Professor of Anatomy and Developmental Genetics at the University of Nottingham, UK. She obtained a BSc from the University of Derby, England, a master’s degree from Technische Universität München, Germany, and a Ph.D. from the University of Nottingham. She undertook a post-doctoral research fellowship in the School of Medicine before accepting tenure in Veterinary Medicine and Science. Dr. Rutland also obtained an MMedSci (Medical Education) and a Postgraduate Certificate in Higher Education (PGCHE). She is the author of more than sixty peer-reviewed journal articles, twelve books/book chapters, and more than 100 research abstracts in cardiovascular biology and oncology. She is a board member of the European Association of Veterinary Anatomists, Fellow of the Anatomical Society, and Senior Fellow of the Higher Education Academy. 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