CNS toxicity—lidocaine plasma concentrations and its effects [17].
\\n\\n
\\n"}]',published:!0,mainMedia:{caption:"Milestone",originalUrl:"/media/original/124"}},components:[{type:"htmlEditorComponent",content:'
Barely three months into the new year and we are happy to announce a monumental milestone reached - 150 million downloads.
\n\nThis achievement solidifies IntechOpen’s place as a pioneer in Open Access publishing and the home to some of the most relevant scientific research available through Open Access.
\n\nWe are so proud to have worked with so many bright minds throughout the years who have helped us spread knowledge through the power of Open Access and we look forward to continuing to support some of the greatest thinkers of our day.
\n\nThank you for making IntechOpen your place of learning, sharing, and discovery, and here’s to 150 million more!
\n\n\n\n\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"5195",leadTitle:null,fullTitle:"Magnetic Materials",title:"Magnetic Materials",subtitle:null,reviewType:"peer-reviewed",abstract:"This book reports on the recent progresses in theory, application, and characterization of magnetic materials. It covers a broad spectrum of topics on magnetic materials with different shapes and morphologies such as transition metals, cylindrical and 2D ferromagnetic nanowires, core-shell nanowires, monoatomic-layered nanostructures, and nanocrystals. This book addresses diverse groups of readers with general background in physics and material science and also covers topics for the specialists in the field of magnetism. It is believed that this book will be interesting for the readers and will provide a solid foundation about the topic for the students, scientists, and engineers working in the field of material science and condensed matter physics.",isbn:"978-953-51-2428-3",printIsbn:"978-953-51-2427-6",pdfIsbn:"978-953-51-6670-2",doi:"10.5772/61497",price:119,priceEur:129,priceUsd:155,slug:"magnetic-materials",numberOfPages:278,isOpenForSubmission:!1,isInWos:1,isInBkci:!1,hash:"4f04cfbb54e455378de5fc7725e36a0c",bookSignature:"Khan Maaz",publishedDate:"August 24th 2016",coverURL:"https://cdn.intechopen.com/books/images_new/5195.jpg",numberOfDownloads:17941,numberOfWosCitations:9,numberOfCrossrefCitations:2,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:5,numberOfDimensionsCitationsByBook:0,hasAltmetrics:0,numberOfTotalCitations:16,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"October 14th 2015",dateEndSecondStepPublish:"November 4th 2015",dateEndThirdStepPublish:"February 8th 2016",dateEndFourthStepPublish:"May 8th 2016",dateEndFifthStepPublish:"June 7th 2016",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6,7",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"107765",title:"Dr.",name:"Maaz",middleName:null,surname:"Khan",slug:"maaz-khan",fullName:"Maaz Khan",profilePictureURL:"https://mts.intechopen.com/storage/users/107765/images/system/107765.png",biography:"Dr. Maaz Khan is working as Deputy Chief Scientist (Professor) at PINSTECH, Pakistan. He has done Ph.D. and post doctorate in the field of Material Science (Nanoscience). His research interests include fabrication of nanomaterials and their structural, optical, magnetic, and electrical characterizations. He has authored more than 100 research articles and published 10 books. Presently, he is the Editor-in-Chief of ‘Journal of Materials, Processing and Design\\' and \\'The Nucleus\\'. He is also the Executive Editor of \\'International Journal of Nano Studies and Technology\\'. Dr. Maaz also serves as the editorial board member of several journals of Material Science.",institutionString:"Pakistan Institute of Nuclear Science and Technology",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"9",institution:{name:"Pakistan Institute of Nuclear Science and Technology",institutionURL:null,country:{name:"Pakistan"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"946",title:"Nanotechnology",slug:"metals-and-nonmetals-nanotechnology"}],chapters:[{id:"51314",title:"Scaling in Magnetic Materials",doi:"10.5772/63285",slug:"scaling-in-magnetic-materials",totalDownloads:1772,totalCrossrefCites:0,totalDimensionsCites:2,hasAltmetrics:0,abstract:"The chapter presents applications of the scaling in several problems of magnetic materials. Soft magnetic materials (SMMs) and soft magnetic composites (SMCs) are considered. Application of scaling in investigations of problems, such as power losses, losses separation, data collapse of the losses characteristics and modelling of the magnetic hysteresis, is presented. The symmetry group generated by scaling and gauge transformations enables us to introduce the classification of the hysteresis loops with respect to the equivalence classes. SMC materials require special treatment in the production process. Therefore, algorithms for optimization of the power losses are created. The algorithm for optimization processes is based on the scaling and the notion of the pseudo-equation of state. The scaling makes modelling and calculations easy; however, the data must obey the scaling. Checking procedure of statistical data to this respect is presented.",signatures:"Krzysztof Z. Sokalski, Barbara Ślusarek and Jan Szczygłowski",downloadPdfUrl:"/chapter/pdf-download/51314",previewPdfUrl:"/chapter/pdf-preview/51314",authors:[{id:"179335",title:"Prof.",name:"Krzysztof",surname:"Sokalski",slug:"krzysztof-sokalski",fullName:"Krzysztof Sokalski"},{id:"181153",title:"Prof.",name:"Barbara",surname:"Slusarek",slug:"barbara-slusarek",fullName:"Barbara Slusarek"},{id:"181154",title:"Prof.",name:"Jan",surname:"Szczyglowski",slug:"jan-szczyglowski",fullName:"Jan Szczyglowski"}],corrections:null},{id:"51443",title:"How to Characterize Cylindrical Magnetic Nanowires",doi:"10.5772/63482",slug:"how-to-characterize-cylindrical-magnetic-nanowires",totalDownloads:1692,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Cylindrical magnetic nanowires made through the help of nanoporous alumina templates are being fabricated and characterized since the beginning of 2000. They are still actively investigated nowadays, mainly due to their various promising applications, ranging from high-density magnetic recording to high-frequency devices, passing by sensors, and biomedical applications. They also represent suitable systems in order to study the dimensionality effects on a given material. With time, the development in fabrication techniques allowed to increase the obtained nanowire complexity (controlled crystallinity, modulated composition and/or geometry, range of materials, etc.), while the improvements in nanomanipulation permitted to fabricate system based either on arrays or on single nanowires. On the other side, their increased complexity requires specific physical characterization methods, due to their particular features such as high anisotropy, small magnetic volume, dipolar interaction field between them, and interesting electronic properties. The aim of this chapter was to offer an ample overview of the magnetic, electric, and physical characterization techniques that are suitable for cylindrical magnetic nanowire investigation, of what is the specific care that one needs to take into account and which information will be extracted, with typical and varied examples.",signatures:"Fanny Béron, Marcos V. Puydinger dos Santos, Peterson G. de\nCarvalho, Karoline O. Moura, Luis C.C. Arzuza and Kleber R. Pirota",downloadPdfUrl:"/chapter/pdf-download/51443",previewPdfUrl:"/chapter/pdf-preview/51443",authors:[{id:"180153",title:"Prof.",name:"Fanny",surname:"Béron",slug:"fanny-beron",fullName:"Fanny Béron"},{id:"180848",title:"MSc.",name:"Peterson",surname:"Grandini De Carvalho",slug:"peterson-grandini-de-carvalho",fullName:"Peterson Grandini De Carvalho"},{id:"180849",title:"MSc.",name:"Luis Carlos",surname:"Costa Arzuza",slug:"luis-carlos-costa-arzuza",fullName:"Luis Carlos Costa Arzuza"},{id:"180850",title:"MSc.",name:"Karoline",surname:"Moura",slug:"karoline-moura",fullName:"Karoline Moura"},{id:"180851",title:"Dr.",name:"Marcos",surname:"Puydinger Dos Santos",slug:"marcos-puydinger-dos-santos",fullName:"Marcos Puydinger Dos Santos"},{id:"180853",title:"Prof.",name:"Kleber Roberto",surname:"Pirota",slug:"kleber-roberto-pirota",fullName:"Kleber Roberto Pirota"}],corrections:null},{id:"51213",title:"Magnetization Dynamics–Induced Charge and Spin Transport on the Surface of a Topological Insulator Subjected to Magnetism",doi:"10.5772/62531",slug:"magnetization-dynamics-induced-charge-and-spin-transport-on-the-surface-of-a-topological-insulator-s",totalDownloads:1349,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"We theoretically show spin and charge transport on the disordered surface of a three‐dimensional topological insulator with a magnetic insulator when localized spin of the magnetic insulator depends on time and space. To ascertain the transports, we use a low‐energy effective Hamiltonian on the surface of a topological insulator using the exchange interaction and calculate analytically using Green's function techniques within the linear response to the exchange interaction. As a result, the time‐dependent localized spin induces the charge and spin current. These currents are detected from change in the half‐width value of the ferromagnetic resonance of the localized spin when the magnetic resonance of the localized spin is realized in the attached magnetic insulator. We also show spin and charge current generation in a three‐dimensional Weyl–Dirac semimetal, which has massless Dirac fermions with helicity degrees of freedoms. The time‐dependent localized spin drives the charge and spin current in the system. The charge current as well as the spin current in the Weyl–Dirac system are slightly different from those on the surface of the topological insulator.",signatures:"Katsuhisa Taguchi",downloadPdfUrl:"/chapter/pdf-download/51213",previewPdfUrl:"/chapter/pdf-preview/51213",authors:[{id:"181168",title:"Dr.",name:"Katsuhisa",surname:"Taguchi",slug:"katsuhisa-taguchi",fullName:"Katsuhisa Taguchi"}],corrections:null},{id:"51474",title:"Metamaterial Properties of 2D Ferromagnetic Nanostructures: From Continuous Ferromagnetic Films to Magnonic Crystals",doi:"10.5772/64070",slug:"metamaterial-properties-of-2d-ferromagnetic-nanostructures-from-continuous-ferromagnetic-films-to-ma",totalDownloads:1506,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"In recent years the study of low-dimensional magnetic systems has become topical not only for its several technological applications but also for achieving a deep understanding of the underlying physics of magnetic nanostructures. These efforts have considerably advanced the field of magnetism both theoretically and from an experimental point of view. Very recently, for their challenging features, great attention has been given to the investigation of the static and dynamical properties of magnetic nanostructures with special regard to magnonic crystals, a class of periodic magnetic systems. As shown by micromagnetic and analytical methods, the ferromagnetic materials composing magnonic crystals can be regarded as metamaterials since they exhibit effective properties directly linked, for instance, to the definition of an effective magnetization, an effective permeability, and an effective wavelength. Hence, the aim of this chapter is to give an overview of the recent results obtained on the study of metamaterial properties of two-dimensional ferromagnetic nanostructures ranging from those of thin films to the ones of two-dimensional magnonic crystals. Some possible applications based on the effective properties for tailoring new magnetic devices are suggested.",signatures:"Roberto Zivieri",downloadPdfUrl:"/chapter/pdf-download/51474",previewPdfUrl:"/chapter/pdf-preview/51474",authors:[{id:"181334",title:"Prof.",name:"Roberto",surname:"Zivieri",slug:"roberto-zivieri",fullName:"Roberto Zivieri"}],corrections:null},{id:"51707",title:"Molecular Magnetism Modeling with Applications in Spin Crossover Compounds",doi:"10.5772/64281",slug:"molecular-magnetism-modeling-with-applications-in-spin-crossover-compounds",totalDownloads:2101,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Molecular magnetic materials have become flourishing fields for research and technological developments due to their novel behavior compared to classical magnetic materials. Molecular magnetism modeling has reached a certain degree of maturity, although several experimental findings are still open problems. This chapter is aimed at providing a general introduction to physical modeling in molecular materials with a special emphasis placed on spin crossover compounds. This presentation includes Ising-type models and their generalizations, such as Wajnflasz and Pick, Bousseksou et al., Zimmermann and König, Sorai and Seki, and Nasser et al., along with their applications to the characterization of phase transition, hysteresis behavior, and thermal relaxations in spin crossover compounds. Recent experimental findings are explained in this context and the relevance of theoretical results for technological applications is also discussed.",signatures:"Mihai Dimian and Aurelian Rotaru",downloadPdfUrl:"/chapter/pdf-download/51707",previewPdfUrl:"/chapter/pdf-preview/51707",authors:[{id:"179954",title:"Dr.",name:"Mihai",surname:"Dimian",slug:"mihai-dimian",fullName:"Mihai Dimian"},{id:"181093",title:"Dr.",name:"Aurelian",surname:"Rotaru",slug:"aurelian-rotaru",fullName:"Aurelian Rotaru"}],corrections:null},{id:"50157",title:"Proteresis of Core-Shell Nanocrystals: Investigation through Theoretical Simulation and Experimental Analysis",doi:"10.5772/62398",slug:"proteresis-of-core-shell-nanocrystals-investigation-through-theoretical-simulation-and-experimental-",totalDownloads:1589,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"A study of proteresis (inverted hysteresis) in core-shell nanocrystals is presented. A core-shell anisotropic energy (CSAE) model is established to describe the observed proteretic behavior in Ni/NiO core-shell nanocrystals. The magnetic compositions of core-shell nanocrystals can be selected for ferromagnetic, antiferromagnetic, or paramagnetic materials where the exchange intercoupling between them results in both a large effective anisotropic energy and intercoupling energy. Simulation of the magnetization of core-shell nanocrystals reveals the existence of an exchange in the intercoupling energy between the interface of the core and shell moments that, surprisingly, is tuneable in both hysteresis and proteresis. Observations have shown a distinct proteresis, which is related to the spin-flip and exchange intercoupling energy between Ni and NiO. Our approach shows that the processing-dependent technology plays an important role when the grain size decreases to the order of nanometers and when the magnets are reduced from the single domain to core-shell domain. Integrated studies of process-dependent, theoretical modeling and core-shell nanocrystal fabrication technology will lead to more encouraging development in the overunity industry.",signatures:"Jhong-Yi Ji and Sheng Yun Wu",downloadPdfUrl:"/chapter/pdf-download/50157",previewPdfUrl:"/chapter/pdf-preview/50157",authors:[{id:"7156",title:"Prof.",name:"Sheng Yun",surname:"Wu",slug:"sheng-yun-wu",fullName:"Sheng Yun Wu"},{id:"184417",title:"Dr.",name:"Jhong-Yi",surname:"Ji",slug:"jhong-yi-ji",fullName:"Jhong-Yi Ji"}],corrections:null},{id:"50909",title:"Radiation and Propagation of Waves in Magnetic Materials with Helicoidal Magnetic Structure",doi:"10.5772/64014",slug:"radiation-and-propagation-of-waves-in-magnetic-materials-with-helicoidal-magnetic-structure",totalDownloads:1618,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"In this chapter, we are shortly reviewing some problems of electromagnetic and acoustic wave propagation and radiation in the magnets with helicoidal spin structure. We show the band structure of the coupled wave spectrum in the materials. The band gap width depends on the spiral angle (or, equivalently, on external magnetic field value). Interaction of spin and electromagnetic waves leads to opening the gap in spin-electromagnetic dispersion. This gap leads to opacity window in reflection spectrum of spiral magnet plate. The opacity window closes at phase transition into collinear ferromagnetic state and reaches a maximum at simple spiral state. At the frequencies near band gap boundaries, the rotation of polarization plane of propagating electromagnetic wave is observed. Account of interaction of spin and electromagnetic waves with acoustic subsystem leads to opening the gap in spin-acoustic spectrum. This gap leads to some features in electromagnetic reflectance spectrum and to rotation of acoustic wave polarization plane, i.e. to acoustic Faraday effect. We also show the possibility of acoustic and electromagnetic wave radiation by helicoidal magnets at phase transition into collinear ferromagnetic state. Some features of electromagnetic waves generation by spiral magnets placed in homogeneous magnetic field with harmonical time-dependence are also discussed.",signatures:"Igor V. Bychkov, Dmitry A. Kuzmin and Vladimir G. Shavrov",downloadPdfUrl:"/chapter/pdf-download/50909",previewPdfUrl:"/chapter/pdf-preview/50909",authors:[{id:"178503",title:"Prof.",name:"Igor",surname:"Bychkov",slug:"igor-bychkov",fullName:"Igor Bychkov"},{id:"179168",title:"Dr.",name:"Dmitry",surname:"Kuzmin",slug:"dmitry-kuzmin",fullName:"Dmitry Kuzmin"},{id:"179169",title:"Prof.",name:"Vladimir",surname:"Shavrov",slug:"vladimir-shavrov",fullName:"Vladimir Shavrov"}],corrections:null},{id:"50527",title:"Giant Magnetoimpedance Effect and AC Magnetic Susceptibility in Amorphous Alloys System of FeCoNbBSiCu",doi:"10.5772/63024",slug:"giant-magnetoimpedance-effect-and-ac-magnetic-susceptibility-in-amorphous-alloys-system-of-feconbbsi",totalDownloads:1457,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The study of Giant Magnetoimpedance (GMI) effect of the amorphous alloys system of Fe72-xCoxNb6B10Si11Cu1 (for x = 35 and x = 40 at. percent Co) and AC magnetic susceptibility for the amorphous alloy of Fe37Co35Nb6B11Si10Cu1 composition are presented in this chapter. The importance of GMI effect for the improvement of technological applications in sensor devices in amorphous magnetic Fe- and Co-based alloys is introduced; then it is described as the experimental procedure of magnetoimpedance and AC magnetic susceptibility measurements. The obtained results are discussed and finally the conclusions are presented.",signatures:"Zulia Isabel Caamaño De Ávila, Amilkar José Orozco Galán and\nAndrés Rosales-Rivera",downloadPdfUrl:"/chapter/pdf-download/50527",previewPdfUrl:"/chapter/pdf-preview/50527",authors:[{id:"181146",title:"Dr.",name:"Zulia",surname:"Caamaño",slug:"zulia-caamano",fullName:"Zulia Caamaño"}],corrections:null},{id:"51160",title:"Magnetization Statics and Ultrafast Photoinduced Dynamics in Co/garnet Heterostructures",doi:"10.5772/62542",slug:"magnetization-statics-and-ultrafast-photoinduced-dynamics-in-co-garnet-heterostructures",totalDownloads:1513,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"We demonstrate experimental studies of the magnetization behavior from statics to ultrafast photoinduced dynamics with high temporal resolution in ultrathin Co/garnet heterostructures with a sub-nanometer roughness at the interface. We report on modulation of spin precession in Co/garnet heterostructures with distinct frequencies and show that the excitation efficiency of these precessions strongly depends on the amplitude and the direction of external magnetic field. Furthermore, it is shown that the magnetization precession in the garnet film can be manipulated by the strong magnetostatic coupling between Co and garnet layers. These findings could provide new possibilities in all-optical excitation and local spin manipulation by polarized femtosecond pulses for the application in nanodevices with high-speed switching.",signatures:"Andrzej Stupakiewicz",downloadPdfUrl:"/chapter/pdf-download/51160",previewPdfUrl:"/chapter/pdf-preview/51160",authors:[{id:"41112",title:"Dr.",name:"Andrzej",surname:"Stupakiewicz",slug:"andrzej-stupakiewicz",fullName:"Andrzej Stupakiewicz"}],corrections:null},{id:"51644",title:"Magnetic Micro-Origami",doi:"10.5772/64293",slug:"magnetic-micro-origami",totalDownloads:1670,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Microscopic origami figures can be created from thin film patterns using surface tension of liquids or residual stresses in thin films. The curvature of the structures, direction of bending, twisting, and folding of the patterns can be controlled by their shape, thickness, and elastic properties and by the strength of the residual stresses. Magnetic materials used for micro- and nano-origami structures play an essential role in many applications. Magnetic force due to applied magnetic field can be used for remote actuation of microrobots. It can also be used in targeted drug delivery to direct cages loaded with drugs or microswimmers to transport drugs to specific organs. Magnetoelastic properties of free-standing micro-origami patterns can serve for stress or magnetic field sensing. Also, the stress-induced anisotropy and magnetic shape anisotropy provide a convenient method of tuning magnetic properties by designing a shape of the micro-origami figures instead of varying the composition of the films. Micro-origami figures can also serve as building blocks for two- and three-dimensional meta-materials with unique properties such as negative index of refraction. Micro-origami techniques provide a powerful method of self-assembly of magnetic circuits and integrating them with microelectro-mechanical systems or other functional devices.",signatures:"Leszek Malkinski and Rahmatollah Eskandari",downloadPdfUrl:"/chapter/pdf-download/51644",previewPdfUrl:"/chapter/pdf-preview/51644",authors:[{id:"115596",title:"Dr.",name:"Leszek",surname:"Malkinski",slug:"leszek-malkinski",fullName:"Leszek Malkinski"},{id:"187129",title:"MSc.",name:"Rahmatollah",surname:"Eskandari",slug:"rahmatollah-eskandari",fullName:"Rahmatollah Eskandari"}],corrections:null},{id:"51165",title:"Magnetic Properties of Gadolinium-Doped ZnO Films and Nanostructures",doi:"10.5772/63320",slug:"magnetic-properties-of-gadolinium-doped-zno-films-and-nanostructures",totalDownloads:1674,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The magnetic properties of Gd-doped ZnO films and nanostructures are important to the development of next-generation spintronic devices. Here, we elucidate the significant role played by Gd-oxygen-deficiency defects in mediating/inducing ferromagnetic coupling in in situ Gd-doped ZnO thin films deposited at low oxygen pressure by pulsed laser deposition (PLD). Samples deposited at higher oxygen pressures exhibited diamagnetic responses. Vacuum annealing was used on these diamagnetic samples (grown at a relatively high oxygen pressures) to create oxygen-deficiency defects with the aim of demonstrating reproducibility of room-temperature ferromagnetism (RTFM). Samples annealed at oxygen environment exhibited superparamagnetism and blocking-temperature effects. The samples possessed secondary phases; Gd segregation led to superparamagnetism. Theoretical studies showed a shift of the 4f level of Gd to the conduction band minimum (CBM) in Gd-doped ZnO nanowires, which led to an overlap with the Fermi level, resulting in strong exchange coupling and consequently RTFM.",signatures:"Iman S. Roqan, S. Assa Aravindh and Singaravelu Venkatesh",downloadPdfUrl:"/chapter/pdf-download/51165",previewPdfUrl:"/chapter/pdf-preview/51165",authors:[{id:"181087",title:"Dr.",name:"Iman",surname:"Roqan",slug:"iman-roqan",fullName:"Iman Roqan"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"6552",title:"Silver Nanoparticles",subtitle:"Fabrication, Characterization and Applications",isOpenForSubmission:!1,hash:"fa35924b88365602189440c335634a77",slug:"silver-nanoparticles-fabrication-characterization-and-applications",bookSignature:"Khan Maaz",coverURL:"https://cdn.intechopen.com/books/images_new/6552.jpg",editedByType:"Edited by",editors:[{id:"107765",title:"Dr.",name:"Maaz",surname:"Khan",slug:"maaz-khan",fullName:"Maaz Khan"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited 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by"}}},ofsBook:{item:{type:"book",id:"11678",leadTitle:null,title:"Cytotoxicity",subtitle:null,reviewType:"peer-reviewed",abstract:"
\r\n\tMedical devices and pharmaceutical agents must undergo rigorous testing to determine their biocompatibility when they have contact with the body, regardless of their mechanical, physical, and chemical properties. All new drugs and medical devices must undergo biocompatibility tests of cytotoxicity, sensitization, intradermal irritation, acute systemic toxicity, and a series of tests before entering a clinical environment to ensure safe and effective use for humans.
\r\n\tCell viability is defined as the number of healthy cells in a sample and proliferation of cells is a vital indicator for understanding the mechanisms inaction of certain genes, proteins, and pathways involved in cell survival or death after exposure to toxic agents. The methods used to determine viability are also common for the detection of cell proliferation. A cell viability assay is performed based on the ratio of live and dead cells. This assay is based on an analysis of cell viability in cell culture for evaluating in vitro drug effects in cell-mediated cytotoxicity assays for monitoring cell proliferation. Various methods are involved in performing a cell viability assay, including the dilution method, surface viable count, roll tube technique, nalidixic acid method, fluorogenic dye assay, and the Trypan Blue Cell Viability Assay. The cell viability assays can determine the effect of drug candidates on cells and be used to optimize the cell culture conditions. The parameters that define cell viability can be as diverse as the redox potential of the cell population, the integrity of cell membranes, or the activity of cellular enzymes.
\r\n\tCytotoxicity is the degree to which a substance can cause damage to a cell. Cytotoxicity assays measure the ability of cytotoxic compounds to cause cell damage or cell death. Cytotoxicity assays are widely used in fundamental research and drug discovery to screen libraries for toxic compounds. The cell cytotoxicity and proliferation assays are mainly used for drug screening to detect whether the test molecules have effects on cell proliferation or display direct cytotoxic effects. In a cell-based assay, it is important to know how many viable cells are remaining at the end of the experiment. There are a variety of assay methods based on various cell functions such as enzyme activity, cell membrane permeability, cell adherence, ATP production, co-enzyme production, and nucleotide uptake activity. These methods could be classified in to different categories: (I) dye exclusion methods such as trypan blue dye exclusion assay, (II) methods based on metabolic activity, (III) ATP assay, (IV) sulforhodamine B assay, (V) protease viability marker assay, (VI) clonogenic cell survival assay, (VII) DNA synthesis cell proliferation assays and (V) Raman micro-spectroscopy.
\r\n\tMedical devices have been widely used in various clinical disciplines and these devices have direct contact with the tissues and cells of the body, they should have good physical and chemical properties as well as good biocompatibility. Biocompatibility testing assesses the compatibility of medical devices with a biological system. It studies the interaction between the device and the various types of living tissues and cells exposed to the device when it comes into contact with patients.
\r\n\t
\r\n\tThe book will cover original studies, reviews, all aspects of Cell Viability and Cytotoxicity assays, methods, Biocompatibility of studies of biomedical devices, and related topics.
Local anesthetics (LA) are widely used in clinical practice in anesthesiology. They possess the common property of transient interruption in the neural conduction, and in the fibers C and Aδ, they cause interruption of pain transmission. Pharmacologically, there is a selective blockade of Na+ channels [1, 2]. The mechanism of action of LA is not related only to binding to the Na+ channels. LA have an important role in other targets (channels and receptors); for example, in K+ and Ca++ channels, they have an anti-inflammatory effect by bounding to G protein (inhibiting the adhesion of polymorphonuclear leukocytes, macrophages, and monocytes), increase the release of glutamate, as well as interfering in the activity of some intracellular signaling pathways [3, 4].
There are at least five applications for the use of LA in anesthesiology: local infiltration, regional intravenous anesthesia (Bier block), peripheral nerve block, central nervous system (CNS) blockade (spinal anesthesia, epidural, and caudal), and topical deposit (EMLA, eye drops in ophthalmology) [3]. In this chapter, we will discuss its application in the infiltration of the operative wound and its effects in the inflammatory process, after a brief discussion about the pharmacological structure of LA.
The Na+ channel is composed of one alpha subunit and one or two beta subunits, which can be present in three different states: resting, open, and inactivated (Figure 1). The AL binds to the Na+ channel after crossing the plasma membrane, that is, they bind to an internal portion of the alpha subunit preventing its activation and consequent depolarization of the membrane (Figure 2). Thus, the impulse is not propagated through the neurons, which prevents the perception of nociceptive pain [5, 6].
Na+ channels—it opens with the voltage changes (depolarization) propagated by the electrical impulse.
The electric stimuli are not able to open the Na+ channel because it is blocked by the LA.
In its chemical structure, the LA are weak bases that possess in its molecule a lipophilic portion (aromatic ring) and another hydrophilic (tertiary amine) separated by an intermediate chain (hydrocarbon chain containing an ester or an amide group) (Figure 3) [7, 8].
LA generic structural formula.
The latter allows the classification of LA in amino-esters or amino-amides. These two groups differ in relation to its biotransformation site (the ester forms are metabolized by plasmatic esterases, while amide forms are degraded by hepatic enzymes) [9, 10].
Regarding the allergenic potential—the para amino benzoic acid (PABA) is an allergenic metabolite of the amino esters. Caution must be observed with some LA formulations, because methylparaben and metabisulfite are allergenic used as a preservative [11].
The size of the alkyl chain, in the amino group or aromatic ring, confers the LA molecule its hydrophobic character and its permeability in the lipid bilayer. So, the larger the nitrogenated radicals will be their potency and duration of LA blockades [12].
Followed by the application of AL in the patient, a fraction will be absorbed by the bloodstream (plasma). Depending on the dose administered, the LA may reach higher or lesser degree the noble organs (e.g., brain and heart) producing physiological alterations in these tissues as well. The total dose used should comply with a maximum limit to try to avoid these undesirable effects, known as systemic LA toxicity [13]. Usually, in clinical practice, we must respect the maximum dose of each LA. Note that the CNS effects of lidocaine vary according to its plasma concentration (Table 1)—the higher the plasma concentration, the greater the risk to the patient, even develop a cardio-respiratory arrest. Thus, it is mandatory to observe the maximum allowable doses for each LA.
Plasma concentration (mcg/mL) | Effect |
---|---|
1–5 | Analgesia |
5–10 | Numbness of tongue, tinnitus |
10–15 | Seizures |
15–25 | Coma, respiratory failure |
>25 | CV depression |
CNS toxicity—lidocaine plasma concentrations and its effects [17].
LA may also induce cardiac toxicity depending on the dose employed, acting directly in the heart (specialized conduction tissues) and decreasing the contractility of ventricular myocytes. Bupivacaine is more cardio depressor than lidocaine [14, 15, 16].
The duration of action of LA is influenced by its effect on the vascular smooth muscle tone (vasoconstriction/vasodilatation) adjacent to the place where it is deposited. Other factors that determine its duration include the volume and concentration used, the approach itself (infiltrative versus regional peripheral nerve versus CNS blocks), the target tissue (fiber’s diameter and myelin sheath), and the plasma protein binding (drug-specific affinity).
Long-term LA are the most used in clinical practice in anesthesiology at the following maximal allowed doses—bupivacaine (2 mg/kg), levobupivacaine (2 mg/kg), and ropivacaine (3 mg/kg).
Bupivacaine is presented as a racemic mixture of enantiomers R+ and S−. The optical isometry due to the presence of a chiral carbon (asymmetric) confers several possibilities in the formulation of the LA.
Bupivacaine promotes differential conduction blockade. As it produces more sensory than motor blockade, it plays an important role in the postoperative pain control. The use of epinephrine (5 μg/mL) gives a small increase in its duration of action (as opposed to lidocaine, which takes great advantage over this association). The use of large volumes for infiltration should be taken with cautious and done gradually and intermittently (3–5 mL at 5 min intervals). The patient should always be monitored to detect any unintentional intravascular injection of LA. Bupivacaine presents a higher risk of cardiac toxicity, when compared to levobupivacaine and ropivacaine. Every injection of this anesthetic should be done with the utmost care, always checking the positioning of the needle (by aspirating the syringe ensuring that the needle bevel is not intravascular).
This anesthetic is the S-isomer of the bupivacaine, having the advantage of less neuro-cardio-toxicity due to lower affinity for these tissues. From a cardiac point of view, it causes a shorter prolongation of the QT interval and lower negative inotropism than racemic or R+ bupivacaine [18]. Its analgesic profile is similar to bupivacaine, because its duration of action is also long-lasting. Like ropivacaine, it has an intrinsic vasoconstrictor effect.
It is an anesthetic formulated by the pure enantiomer S of 1-propyl 2′-6′ pipecoloxylide [19]. As levobupivacaine, it has a safer profile than bupivacaine, because it has a lower toxicity in the CNS and heart. Its duration of action is long-lasting, like that of bupivacaine and levobupivacaine. It is widely used in infiltrative anesthesia and peripheral nerve blocks in anesthesiology. The same precautions should be taken with the use (intermittent and monitored injections). It is worth remembering that ropivacaine possesses intrinsic vasoconstrictor effect, which confers lower vascular absorption and increases its duration of action (levobupivacaine also owns this property).
New methods of releasing the LA have been used in order to prolong the analgesia conferred by these anesthetic drugs. One of them is to produce liposomes spheres loaded with LA. This system allows LA deposit in the center of the liposomes, being involved by a double lipid layer. This setting allows a slower, controlled, and gradual release of LA, (72–96 h), consequently providing extended analgesic duration [20, 21, 22, 23]. Liposomal bupivacaine (LB) has a decreased spread when compared with conventional bupivacaine. Therefore, several injections are needed and next to each other to obtain better results. In the infiltrative technique, it should be injected continuously from the fascia to the dermis. Unlike conventional formulations, which use bupivacaine HCl, the LB is produced only with its unprotonated basic form.
When the LA is used to infiltrate the operative wound, the anesthesiologist should seek a balance between the dose employed considering the size of the area to be anesthetized. In other words, it is sought to dilute the total dose used to cover most of the tissues operated. Thus, the same amount of LA used for infiltration on one side (e.g., right breast) needs to be diluted (doubling the volume) and to be employed bilaterally (e.g., right and left breast), always keep in mind that we must respect the maximum safety doses.
This approach allows an alternative to single dose injection of LA, namely the implantation of catheters for complementary use of the medication (continuous and/or in bolus, known as Patient Controlled Analgesia PCA) in order to prolong its therapeutic effect. In clinical practice, these resources increase costs because they need to be supervised, in addition to the increased risk of infection at the catheter implant site. New approaches are being investigated to optimize postoperative analgesia—use of newer drugs, innovative delivery systems (liposomal bupivacaine and ropivacaine), and the use of adjuvants along with LA.
With the advent of several approaches in the treatment of postoperative pain, the anesthesiologist can associate the use of various drugs and techniques aiming at greater efficacy in their control. The simultaneous use of several drugs (with pharmacological synergism) allows the anesthesiologist to decrease the total dose employed, when compared to the isolated use of each of them. This is one of the reasons for the use of adjuvants with the LA [24, 25, 26]. Another reason is to reduce opioid consumption in the post-operative period and associated collateral effects.
Usually, there is a consensus about the use of adjuvants in anesthesia, that is, the anesthesiologist must balance risks versus benefits and mainly the common sense. It is his/her responsibility to do the best choice in each case.
Magnesium sulfate antagonizes ionotropic N-methyl-D-aspartate (NMDA) glutamatergic receptor interfering in calcium homeostasis (membrane potential). When injected together with LA in regional anesthesia, some evidence suggest that its use is beneficial [27]. Conversely, the use of magnesium sulfate intravenously is controversial [28, 29].
Dexmedetomidine (DMD) is a strong and highly selective α2-adrenoceptor agonist. When added to local anesthetics can enhance the analgesic efficacy of the peripheral regional nerve block [30]. DMD is eight times more selective than clonidine. It has analgesic, sedative, and antihypertensive effects, when used in systemic route. This substance has been associated with bupivacaine and lidocaine aiming prolonging the analgesic effect [31].
Epinephrine has been used mixed to local anesthetics since a long time ago, and its recommended concentration is 5–10 μg/mL. It has, besides vasoconstrictive action that prolongates the local anesthesia, an analgesic effect mediated by alpha-2 adrenoceptor activation [32]. The vasoconstrictor effect of epinephrine can prevent inadvertent intravascular administration of local anesthetic solutions. Nowadays, the use of ultrasonography made such use largely redundant [33].
The onset time of local anesthesia after single injection was considered clinically significantly reduced when epinephrine was added to lidocaine or bupivacaine, when performing peripheral nerve blocks [34]. Current recommendations, however, allow the use of epinephrine in peripheral blocks only when ultrasonography is not available [35].
Clonidine applied at perineural sites, in doses up to 1.5 mcg/kg, acts as an adjuvant to local anesthetics prolonging analgesia and sensory/motor blocks [36]. It has intrinsic analgesic properties, inhibiting action potentials of C and Aδ fibers, as well as modulates the redistribution of local anesthetics through alpha1-receptors activation [37].
Side effects of this drug are dose dependent and include sedation, by decreasing sympathetic outflow (suppressing the release of norepinephrine in locus ceruleus (CNS) and substantia gelatinosa), hypotension, bradycardia, dry mouth, constipation, dizziness, and drowsiness [38].
Clonidine represents a good addition for the armamentarium of anesthesiologists because it prolongs the duration of analgesia, provides a faster onset of action, and improves the quality of nerve blocks (decreasing opioid consumption) [39, 40].
Morphine is used by several routes and dosages (intrathecal: 100–200 mcg, epidural: 1–5 mg, peripheral nerve block: 75–100 mcg/kg, intravenous and intramuscular) [41]. Despite its use to prolong the analgesia, it is important to the anesthesiologist to pay attention at recommended doses to avoid the undesirable side effects (pruritus, nausea, vomiting, urinary retention, and respiratory failure). Always double check the vials before the administration of this medication because there are several vials currently in use (2, 4, 5, 8, and 10 mg/ml). All vital signals must be monitored at post-anesthetic care unit after the morphine use to early detect any cardiovascular or respiratory complications: bradycardia, hypotension, hypoxemia, and respiratory failure [42].
Dexamethasone, a potent anti-inflammatory agent, has been investigated for its role as an adjuvant to local anesthetics in neuraxial as well as peripheral nerve blocks. This steroid has been used in intrathecal anesthesia (8 mg preservative free), in epidural analgesia (4–8 mg) and as an adjuvant in a variety of peripheral blocks, like brachial plexus, ankle block, and TAP block. A meta-analysis has found it to significantly prolong the duration of brachial plexus block when using conventional local anesthetics solutions [43]. Besides all the researches about the role of dexamethasone in neural block, one question has not been answered yet: is the better and prolonged analgesia caused by systemic effects of the steroid?
The wound healing is a continuous process, but for didactic understanding, it can be divided into four phases [44, 45]. The first phase occurs just after the incision or lesion of the skin, as soon as the blood leaks out of the body. There is a vasoconstriction, and the platelets stick together to initiate the coagulation. This phase is called the hemostasis phase. The platelet plug is reinforced by threads of fibrin. The hemostasis phase occurs very rapidly, in a question of seconds. As the fibrin mesh is formed, the blood is transformed from liquid to a gel state, that is, the pro-coagulant effect of prothrombin. This clot keeps the platelets and blood cells trapped in the wound area. Just after the injury of the skin, the epidermal tissue and the keratinocytes release the interleukin-1 (IL-1) pre-stored in these sites. The coagulation process activates the clotting cascade which is responsible to give the matrix for the influx of inflammatory cells. The degranulation of the platelets releases alpha granules, which secrete growth factors, like epidermal growth factor (EGF), platelet derived growth factor (PDGF), and transforming growth factor-beta (TGF-β). The PDGF and the IL-1 are responsible for attracting neutrophils to the wound site to remove bacteria [44]. The monocytes cells are converted to macrophages by influence of TGF-β, what has an important role in the initiation of the granulation tissue and a many proinflammatory cytokines (IL-1 and IL-6), besides other growth factors, like fibroblast growth factor (FGF), EGF, TGF-β, and PDGF. All these growth factors and the added endothelial cell proliferation ensues the angiogenesis beginning. During this hemostasis phase, the injured blood vessels leak transudate causing localized swelling and cell migrations to the site of wound. The damaged cells, pathogens, and bacteria are removed. White cells, growth factors, nutrients, and enzymes create the swelling, heat, pain, and redness, normally seen in the wound healing. This phase where all these signs appear is called the inflammatory phase. This phase is not a problem unless it is prolonged and excessive. After all the bacteria and debris are removed, the wound is rebuilt with a new tissue made up of collagen and extracellular matrix. This is the proliferative phase. In this phase, new blood vessels are formed, so that the granulation tissue can receive enough oxygen and nutrients. The myofibroblasts are responsible for the contraction of the wound, making the granulation tissue to take the ideal dimensions to the lesion. The granulation in this phase is pink or red. If there is a dark color is a sign of infection, ischemia or poor perfusion. At the end of this process the epitelial cells resurface the wound extension, what is called the maturation or remodelling phase. In this stage, it is wise to maintain the wound moist and hydrated to optimize the epithelialization [46]. Some authors consider that the wound healing has only three phases, and this is comprehensible as long as the hemostasis phase and the inflammatory phase are so concomitant, dynamic, and interactive, that they consider it just as an inflammation phase. In fact, the phases do not have a predetermined duration, as Witte and Barbul showed in their article (Figures 4 and 5), the migration of cells to the wound site and the matrix formation [47].
The time course of different cells during healing process. Macrophages and neutrophils are predominant in inflammation phase, whereas lymphocytes peak somewhat later. In the proliferative phase, fibroblasts are more frequent [
Deposition of wound matrix components over time [
When there is a rupture of vessels, there is an exposure of the subendothelial collagen to the platelets. This contact results in the aggregation and activation of the intrinsic factor of coagulation cascade. In the presence of thrombin, fibronectin, and their fragments, there is the release of cytokines and growth factors from platelets (PDGF), transforming growth factor-β (TGF-β), platelet-activating factor (PAF), fibronectin, and serotonin. All this form the local fibrin clot that is the scaffolding for invading cells such as neutrophils, monocytes, fibroblasts, and endothelial cells. The neutrophils are the first cells to invade the wound, increasing the vascular permeability due to inflammation and release of prostaglandins. In the same time, chemotactic substances like complement factors, interleukin, tumor necrosis factor-α (TNF-α), TGF-β, platelet factor 4, and stimulate neutrophil migration [47, 48, 49]. The factors associated with wound healing can be seen in Table 2.
Function | |
---|---|
Fibrin, plasma fibronectin | Coagulation, chemo attraction Structure for cell migration |
Factor XIII (fibrin-stabilizing factor) Circulatory growth factors | Chemo attraction and adhesion Modulation of chemo attraction, mitogenesis, fibroplasia |
Complement | Antimicrobial activity, chemo attraction |
Cytokines, growth factors | Regulation of chemo attraction, mitogenesis, fibroplasia |
Fibronectin | Early matrix, ligand for platelet aggregation |
Platelet-activating factor (PAF) Thromboxane A2 | Platelet aggregation Vasoconstriction, platelet aggregation, chemotaxis |
Platelet factor IV | Chemotactic for fibroblasts and monocytes, neutralizes activity of heparin, inhibits collagenase |
Serotonin | Induces vascular permeability, chemoattractant for neutrophils |
Adenosine dinucleotide | Stimulates cell proliferation and migration, induces platelet aggregation |
Hemostatic and platelet-derived factors associated with wound healing [47].
When analyzing the possible action of the LAs in the wound healing process, many aspects can take role. Injecting any substance in the surgery site, it is expected that it can have at least a pH influence, as the anesthetic has a pH different of the physiologic one. Many times, epinephrine is used to prolong the duration and lower the toxicity of the drug used [50, 51]. The influence of pain in the wound healing has been studied too [52, 53, 54]. The wound healing in the fetus has also been the object of research [55, 56]. And last, the LA probably can have a direct action in the eicosanoids or in the fibroblast formation and so in the cicatricial process [56].
These all are hypothesis that are discussed deeply, and many researches in human have to be done, unfortunately the majority of the manuscripts are in rats and they have a different immunologic system than humans.
The tissue injury caused by surgery produces directly and indirectly activation of nociceptors and higher expression of proinflammatory cytokines and cyclooxygenase-2 (COX-2), leading to peripheral and central sensitization with subsequent hyperalgesia. The pain and inflammation are maintained by abundant eicosanoids, like prostaglandin E2, released after surgical trauma. The long-acting local anesthetics such as bupivacaine and ropivacaine are used to provide prolonged perioperative pain relief and to diminish the occurrence of postoperative sensitization that manifests with hyperalgesia after the anesthetic effect has dissipated. The occurrence of hyperalgesia is very common when high doses of anesthetic are used [57, 58]. The routine of infiltrating the surgical site reduces the postoperative pain and morbidity and accelerates the recovery. This can be explained by reducing the production of cytokines. Although LA action is to block the nerve conduction, they have other cellular targets that modulate the inflammation, suggesting that the LAs have an anti-inflammatory effect [59, 60]. Several studies have shown that LA dose-dependently inhibits leukocyte adhesion to synthetic material and to blood vessel walls. LA can induce the release of prostacyclin, and this causes the release of leukocytes previously firmly adherent to vascular endothelium. It is shown that the LA can in low concentration stimulate the phospholipase A2 (PLA2) while in higher concentrations inhibited this enzyme [61].
All these considerations are important, but what is important in clinical aspects are the fibroblast formation and the quality of the wound healing. The first question the patient formulates is when he will return to normal life activity. To answer this question, it is important to have not only histological analyzes of the wound but also mechanical testing to be sure that the tissue is ready to normal work. Vasseur and cols in 1984 studied the effects of local anesthetics on abdominal wounds of rabbits [62]; using mechanical testing device, they could demonstrate that the breaking strength in the groups infiltrated with lidocaine or bupivacaine, do not vary consistently from the tissues infiltrated with saline solution, and so they conclude that the local infiltration with lidocaine and bupivacaine does not alter substantially the healing of midline abdominal incisions in rabbits. Abrão and cols in 2014 made a similar work using rats and long-lasting anesthetics, bupivacaine, and ropivacaine [63]. They used a computerized universal testing machine, and they concluded that there were no significant differences among the groups with respect to tensile strength after 14 days. These results, however, are not the same than Hanci and cols in 2012, who found that lidocaine and bupivacaine reduce the collagen production and the wound breaking strength in Wistar rats [64]. To further augment the argument, Kesici and cols in 2018 studied the effect of bupivacaine, levobupivacaine, and procaine in the Sprague Dawley rats [65]. They found that bupivacaine and levobupivacaine affect negatively the wound healing, especially at the late period (21 days). The differences in these studies increase the uncertainty and discussion regarding the effects of local anesthetics. Many aspects must be considered like the animal gender, the use of other analgesic like paracetamol, the infiltration method, and the time of evaluation. Interestingly, there is no work done on humans, who certainly have a different response to pain. Probably, the reason is the difficulty to use the same methodology. All the researches in humans have only clinic evaluation, it is almost impossible to make mechanical tests. Uncertainties in this field only will be clarified with new studies. The clinical studies in human beings have a very subjective way to follow the wound healing. They constitute another subject that must be studied separately. The analogic scale of pain as the consume of opioids has been used as parameters to analyze the efficacy of the method. These studies conclude that ropivacaine (0.3%) can be used alone or with the addition of DMD (1 μg/kg), and there is no effect on wound healing [31, 66]. We must bear in mind that some authors only used a clinic evaluation, what can vary a lot from one researcher to another.
Nowadays, all the anesthesiologists are engaged in avoiding the excessive use of opioids for their side effects in the postoperative pain treatment. In fact, the μ-opioid receptors are impaired by the unrestricted use of morphine like drugs, besides there is an inhibition of the beta-endorphin release. Considering that the infiltration of LA in the surgical site does not produce, clinically any significant harm to the tissue cicatrization, and has the property of sparing opioid use, this technique is an important tool in the control of the postoperative pain and must be recommended.
We declare that we do not have any conflict of interest.
Trade is an integral part of economic activity and development. In global economic system, countries exchange various products as well as intermediate goods/inputs. International trade creates network of economic activity which are generally called trade networks or supply chains. Supply chains are the major enablers of world trade and the world is connected through supply chains. The world economy is strongly connected and influenced by supply chains and its developments. According various industry reports/studies, the best companies are the ones which are having best Supply Chains [1]. Global competition is forcing organizations to build suitable competencies to reduce cost and improve customer service on continuous basis. Corporations have realized that substantial cost savings and market benefits can be achieved by more effective management of their supply chains globally. Advances in information/communication systems and quantitative modeling are also being widely implemented, which provide the potential for access and analysis of comprehensive data/information from each element of the supply chain. One of the main objectives of supply chain is to link the markets, distribution system, manufacturing and allied processes and the procurement to serve its customers across different parts of the world at lower cost and higher service levels. Various developments in technologies, trade policies lead to strong economic growth of the world. Supply chains facilitated globalization of trade for a long time. Various disruptions challenged the globalization. COVID-19 crisis has led to the greatest disruption of supply chains worldwide. COVID-19 crisis not only disrupted the global supply chains and it has thrown lot of challenges to politicians, business and overall economy. COVID-19 pandemic has precipitated economic crisis due to disruption of supply chain, manufacturing activities, and suppressed demand. International Monetary Fund (IMF) has projected global economic growth to be negative 4.9%. This economic crisis has resulted in substantial erosion of market capitalization across the globe.
This chapter focus on how supply chains helped in building the economic development before COVID-19 crisis and how these will help to restart the economic development post COVID-19. We present a brief overview of supply chain management with some examples, impact of COVID-19 on supply chains and economy followed by economy recover framework, sectors and strategies.
A supply chain is a system consists of people, material, transformation activities, organizations, information and resources used in fulfilling the demand for a product or service by a customer. Supply chain management deals with transformation of raw materials and components into a finished product/service that is delivered to the end customer [2]. Figure 1 shows a typical supply chain which consists of suppliers, manufacturers, distributors and final customer. These entities are connected through suitable transportation, warehousing and information sharing across the supply network.
A typical supply chain network [
A supply chain is a network between a company and its suppliers to produce and distribute a specific product to the final buyer. Generally, supply chains deal with different activities, people, material, information, financial resource, knowledge & skills. Figure 2 shows various flows that need to be managed in a supply chain. Three important aspects of supply chains include adaptability, alignment and agility. The best supply chains identify structural shifts, sometimes before they occur, by capturing the latest data, filtering out noise, and tracking key patterns [3]. The supply chain also represents the steps it takes to get the product or service from its original state to the customer [2, 3]. Supply chain management is a crucial process because an optimized supply chain results in lower costs and a faster production cycle which helps companies to remain competitive in the business landscape. Some of the important areas that requires attention in supply chains include flow optimization, coordination, risk management, sustainability, safety and security. The best supply chains aren’t just fast and cost effective. They are also agile and adaptable, and they ensure that all their companies’ interests are aligned [3, 4].
Various flows in supply chain [
Supply chain management uses different approaches for efficient integration of its stakeholders like suppliers, manufacturers, warehouses, retailers such that the merchandise is manufactured and supplied to the right customer on time at correct location at correct time at minimal cost and optimal service level [2, 3]. According to Institute for supply management, the supply chain management is defined as “the design and management of seamless, value-added process across organizational boundaries to meet the real needs of the end customer. The development and integration of people and technological resources are critical to successful supply chain integration”. Similarly, Supply Chain Council defines it as “Managing supply and demand, sourcing raw materials and parts, manufacturing and assembly, warehousing and inventory tracking, order entry and order management, distribution across all channels, and delivery to the customer”. Council of Supply Chain Management Professionals defined it as “the planning and management of sourcing and procurement, conversion, and all logistics management activities”. Also includes coordination with channel partners, which can be suppliers, intermediaries, third party service providers, and customers.
SCM is the management of a network of interconnected businesses involved in the provision of product and service packages required by the end customers. The network of interconnected businesses and comprises of three major building blocks Viz., structural, logical and informational [2, 3, 5, 6].
Structural building blocks of a supply chain [
Logical building blocks of a supply chain [
Organizations involved in supply chains need to take several decisions are different levels and different processes. A typical decision spectrum is shown in Figure 5 along with various decisions at different levels. Forecasting is one of the critical inputs that affects the efficiency and responsiveness of the entire supply chain both in short term and long term.
Supply chain decision spectrum [
Order fulfillment also takes into consideration of networking strategies such as allocating inventories in the physical buildings, transportation strategies such as trying new processes and carriers and making changes in the distribution centers. Therefore, the order fulfillment considers cross-functionality of the organization which builds coordination among main suppliers and customers.
There are two major aspects to be considered in post-sales. They are Customer relationship management (CRM), customer service management (CSM). CRM helps in understanding how to provide tailor-made products and services to meet the needs and demands of a customer. CRM through supply chain network and through the delivery of products builds competitive edge of a company against their competitors. The main responsibility of a customer service management lies in refining the relationship with the customers. Customer service management in the SCM building blocks effectively focus on managing customer service on the basis of customer’s preferences, tastes, and perceptions to deliver best of products and services.
Making rational decisions in the context of supply chain management is a complex one. To help managers decide how to proceed, [7] have suggested the following seven principles which were based on the stories of successful organizations in business. These principles include the following [7]:
Customer segmentation based on their needs
Logistics network customization
Observe market demand and plan accordingly
Postponement or delayed differentiation of product closer to the customer demand
Strategic sourcing
Use of SC wide technology strategy
Use of channel wide performance measures
Many organizations around the work have benefited by using these principles and able to meet the customer demand effectively and profitably by strengthening their supply chains. Further, organizations have pursued various initiatives like integration of supply chain activities and these have resulted in improved asset utilization, reduced cost, and created competitive advantage on one hand and improved revenues on the other hand.
Measuring supply chain performance is one of the most difficult tasks in business due to involvement of many stakeholders and different types of activities that they perform in different geographic locations and contexts. However, both industry practioners and researchers have evolved different performance measures which are based on cost, quality, delivery, efficiency, sustainability etc. Some of the mainly used performance measures include delivery performance to request, upside production flexibility/material availability, total supply chain costs, Cash-to-Cash Cycle Time, return on investment, inventory turns, fill rate, customer service level, revenue growth etc.
In this study, we have adopted a generic method for literature search and industry practices in the area of supply chain management in different sectors, reports on economic development, global value chains, world trade and reports on COVID-19. Literature search has been carried out using key words like COVID-19, Supply Chain Management, economy recovery, world trade, global value chain, world GDP, healthcare from the databases like PubMed, Google Scholar, EBSCO, ENKI, ABI Info, etc. The search does not include other databases. Apart from these we have also used information regarding various stimulus packages and sectoral specific schemes for economic recovery in different countries. We have used the information from firms like McKinsey, The Economist, Gartner Inc., World economic forum, World trade organization etc. The author’s own research and consulting experience in the area of supply chain management and healthcare management. Apart from these we have also gathered the information from experts from different fields like policy makers, industry practitioners, consultants, medical physicians from healthcare sector at global level. We have excluded country specific details in the study.
Supply chains are in practice for a very long time in different forms facilitating the trade [5]. After world war II (WW-II), the importance of supply chains has increased significantly and from 1960s its influence has increased duo to developments in computers and information technology. Further, post 1990s due to advent of internet technologies and globalization of trade, the importance of supply chains has increased many fold and the GDP of the world has increased significantly [5, 6, 8] and the same is given in Section 3. Supply chain ecosystem and framework is brief described in the following sub sections.
Figure 6 shows various stakeholders and their relationship in the context of supply chain ecosystem [9]. Supply chain ecosystem is a complex network connecting various stakeholders through suitable technology platforms and incentive systems. This include logistics service providers like third party, forth party logistics providers, reverse and returns, inbound and outbound. Transportation modes would include roadways, railways, airways and seaways. Other services like warehousing, courier and freight services and material handling. SC ecosystem would include platforms, software across different industry verticals like automobile, fast consumer goods, industrial goods, energy, health and other services.
Supply chain ecosystem [
SC platforms are very critical and include connectivity management, application management and data management. Connectivity management include WAN, Wi-Fi, Hotspot, Bluetooth, RFID etc. Due to increase in complexity of SC network, the importance of software has increased significantly and most of the activities are managed through software tools. Software management in the context of SC include network management, streaming, data management, security, internet of things, asset management, asset maintenance, warehouse management, building management, fleet management etc. Advances in information and communication technologies like GPS has further improved the performance and control of supply chain activities. Due to rich data and advances like Artificial Intelligence (AI), Machine learning (ML) are facilitating in more rational and timely decisions across the supply chain.
Supply Chain Operations Reference (SCOR) model is very widely used industry standard model developed by supply chain council in 1996 [10]. SCOR model follows a hierarchical structure and has three levels. Level 1 include five process types viz., plan, source, make, delivery and return. The elements of SCOR model is shown in Figure 7 along with major functions and role of digitization at each stage of the supply chain. Level II include process categories which defines the configuration and level III include process activities in terms of inputs and outputs and performance measures. SCOR model employs five performance measures: reliability, responsiveness, flexibility, costs and asset management. In summary, the traditional SCOR Model has five processes, five performance measures and three levels describing SC comprehensively. Due to technological advancements in data capturing and analysis tools, the digitization across SC has attracted many stakeholders in improving the supply chain performance significantly. Digitization of supply chain functions at each stage is also shown in Figure 7. The most interesting and important element is handling of returns across various industry verticals. Returns in the supply chain have assumed significance due to electronic commerce industry. Of late, AI and Blockchain technologies are playing a critical role in managing the returns across various industry verticals by tracking the product usage history and other relevant information.
SCOR model with traditional and digital focus [
SCOR model covers the following activities:
Covers all interactions of
All transactions related to
All interactions of the
SCOR model allows environmental measures like carbon emissions, air pollution, liquid and solid waste, percent recycled waste etc. SCOR model connects emissions to the processes at source and provide a structure for measuring environmental performance and improvement areas. The hierarchical nature SCOR model allows strategic environmental footprints to be translated to specific activities and targets.
Though the supply chains are widely used in manufacturing industry to start with, subsequently the supply chain concepts and practices have been applied in other sectors including healthcare industry, pharmaceutical, food and agriculture, ecommerce, humanitarian, disaster relief etc. Healthcare is changing at an unprecedented pace, due to the impacts of technology, cost pressures from both payers and patients who are seeking quality care. Healthcare organizations including providers, retailers, distributors and wholesalers, manufacturers. Some of the organization who have adopted supply chain practices include Johnson and Johnson, Cleveland Clinic, Mercy, CVS Health, McKesson, Novo Nordisk, Medtronic, Stryker, Roche, Pfizer, Owens and Minor etc. For example, Mayo Clinic has improved the care delivery and reduction in cost by collaborating with its suppliers and adopting digital technologies in its operations. Figure 8 shows the framework suggested by Gartner in respect of healthcare organizations with a main objective of improving the human life at sustainable costs as well as quality. This model has five major processes viz., patient focus, collaboration, network visibility, cost to serve and change management supported by fundamental capabilities covering all the processes [11].
Healthcare value chain capabilities model [
Due to inherent advantages and capabilities of supply chains, many organizations across different industry/business verticals have adopted supply chains and benefited immensely. Some of the major sectors include automobile, food and agriculture, e-commerce, healthcare including hospitals, pharmaceuticals, diagnostic services, medical devices etc., defense and government, energy and power, oil and gas etc. Supply chains of e-commerce, food and healthcare is briefly explained in this section.
Electronic commerce (e-commerce) supply chains have gained significant importance due to ability of supply chains in meeting the customer service and low cost. Many companies like Amazon, flipkart, Alibaba etc. have demonstrated the power of supply chain in their business operations. Figure 9 shows typical supply chain network of e-commerce supply chains. Figure 10 shows a macro view of supply chain management at Amazon [Amazon.com]. e-commerce supply chains are more robust compared to others mainly due to its ability to manage the disruptions during crisis like COVID-19. Particularly during COVID-19 crisis, Amazon, flipkart and other e-commerce companies were able to maintain the continuity of supply in spite restrictions like lockdowns, social/physical distance and limited time operations, shortage of manpower etc. These companies are able to recover fast due to its resilience and responsiveness capability. This can be seen from the latest trend in the share price of e-commerce and food supply chain companies.
E-commerce supply chain [
Amazon supply chain [
A typical food supply chain with food safety information system and quality assurance system is shown in Figure 11 [14]. The food supply chain includes farm/farmer, distributor, factory, distributor/retailer and final customer. In case of food supply chains the most critical issue is food safety across the supply chain. These supply chains focus very heavily into food safety and traceability at each stage of the supply chain mainly at interfaces. Food supply chains uses information and communication technology widely. Quality and Compliance of standards across food supply chain is very critical and makes use of advanced technologies like RFID, temperature controls, GPS enabled systems for tracking and traceability. It follows standards like good manufacturing practices, ISO standards and TQM etc. [14].
Food supply chain [
Healthcare supply chains are more complex than other supply chains due to presence of many stakeholders and responsiveness requirements. A typical healthcare supply chain is shown in Figure 12. Healthcare supply chains poses several challenges due to stringent regulatory requirements, safety and security and quality requirements. In spite all these challenges, many healthcare organizations benefited by adopting supply chain management approaches. According to Gartner study [11] on top 25 healthcare supply chains, top 5 organizations include Johnson and Johnson, Cleveland Clinic, Mercy, CVS health and Duke University Health system. Many of these organizations are using best practices like collaboration, digitalization, robust processes that are aligned with the overall objective as well as the elements listed in healthcare value chain capabilities model. The major strengths of healthcare supply chains include agility, alignment, adaptability, resilience and responsiveness. These organizations follow people, process and technology solutions in the care delivery. Of late, many healthcare organizations particularly using AI and Blockchain technologies for personalized care in large scale. Telemedicine and home care is growing very fast due to COVID-19 crisis where supply chain is very critical. Some of the organizations are using drones for delivery of medicines, pathology samples, food and equipment. Many start-ups also emerging in healthcare by bridging the gap predominantly through digital technologies and supply chains.
Elements of healthcare supply chain [
Supply chain network structures and its configuration is very important in achieving the performance of supply chains. Predominantly used supply chain structures in the practice include centralized and decentralized [2] or Hub and spoke model. Figure 13 shows typical structure of centralized and decentralized supply chains. Centralized systems are more efficient and are generally used for high volume low value commodities like steel, cement, automobiles, computers etc. where cost is important. Whereas decentralized systems are predominantly used in e-commerce, healthcare and other services where responsiveness is most important. Hub and spoke models are predominantly used is both product and service organizations. A typical hub and spoke model of a Start-up delivering health services in Rural areas in India is shown in Figure 14. Generally, the Hubs are equipped with more resources that can help serving the customers located spoke level. Typically, these share many resources and innovate through collaborative mechanism and employ multi skilled people and technology to improve the efficiency and reach.
Centralized and decentralized supply chain system [
Hub and spoke model of a healthcare start-up [
Supply chains have contributed significantly for the world trade for many years. Further, supply chains have facilitated the globalization of trade. Figure 15, shows the world trade over last four decades [8]. There is a sensitive relationship between economic development and supply chain because efficient management of the supply chain can reduce costs, maximize customer value, and maximize competitive advantage. It entails effective coordination and control of linked sectors, departments, systems, and organizations. According to a study by world economic forum, reducing supply chain barriers could increase world GDP better over import tariffs. Further, the study shows that 50% reduction in supply chain barriers can increase world trade by 14.5% and world GDP by 4.7% and these gains are more evenly distributed across various countries and also it can generate more employment [17].
World trade-exports [
Global trade has increased owing to adoption of liberalization and globalization as national economic policies by several countries in post-Soviet era (post 1992). Global GDP has also expanded in tandem with global trade. An analysis of global merchandise trade and global GDP at market exchange rates with 2008 as base years shows coupled growth in global GDP and global trade as depicted in Figure 16 [18]. Due to emergence of global value chains, the global trade is shifting fast. This can be seen from Figure 16. Expansion of global GDP and its correlation with global trade increases the importance of worldwide network of production of goods. A study done by [8] suggests that contribution of intermediary goods in global trade of manufactured goods was more than that of finished goods during 2001–2008 and 2009–2014. This conclusion supports the existence of complex Global Value Chains (GVC) [19]. Furthermore, as per the available data, 57% of the global trade in 2015 was constituted by trade of intermediate goods [18]. OECD TiVA database shows that the Asian economies have the highest growth rates of contributions in GVCs [20].
Relation between global trade and GDP [
Due to increasing network of global supplies, patterns in global trade have shifted from ‘trade in goods’ to ‘trade in value added’ and ‘trade in tasks’ [19]. The Global Value Chain (GVC) Framework has emerged due to shifting pattern of global trade. It focusses on expanding and strengthening supply chain and value generation therein. Both developing and developed economies get benefited by participation into GVC [8]. Participation into GVC provides an exposure to the global best practices, technological know-how, and competence development. These result in higher economic growth and development [21].
GVC framework provides a strategic overview of global supply chain and integration of different characteristics of complex supply networks into GVC would provide a holistic perspective of various methodologies- operational and strategic [17]. Development of robust supply chain management practices have strengthened GVCs thereby easing cross-border movement of goods. It promotes domestic manufacturing and consumption. These in-turn result in growth of national GDPs. Therefore, to boost global economic growth promotion of global trade is essential. Sustenance of rapid growth in global trade is a function of participation of various countries into GVC which requires a robust supply chain management. From this analysis, it can be concluded that, development in supply-chain practices have contributed substantially to global economic growth.
World class organizations like Walmart, Apple, P & G, Amazon, IBM, Toyota, General Motors, Best Buy, Marks & Spencer’s, Zara, Sports goods companies, mobile companies, food chains have gained significantly by adopting supply chain practices in their business. Similarly, healthcare organizations like CVS Pharma, Cleveland clinic, Narayana Health of India, pharmaceutical companies, medical device and equipment companies and many others have gained significantly.
In 2019 the United States imported a staggering four $52 Billions of goods from China. COVID-19 crisis has created historical disruption to global supply chains. COVID-19 crisis has affected health of people, business and overall economy at global level. COVID-19 crisis is a wake-up call for supply chains and one way it created de-globalization of business and supply chains. Over dependence on one country like China had proved to be very disrupted at times of pandemic. Bloomberg reported in March 2020 that electronic makers are past the point of no return in the gradual migration from China. Further, the Chinese trade (both domestic and international) transactions dropped by around 56% in the mid- February 2020. Similarly, US, UK and Europe also gone through a drop of 26% in April 2020 and touched 17% in late April 2020. Sourcing from India it is recommended an incremental approach in bringing all Indian suppliers i.e., carefully select some low-risk and high reward programs to try out in India while maintaining Chinese base.
Due to COVID-19 crisis companies have fallen into one of two categories those that do not do anything hoping such a deception will not ever happen again those firms that heed the lessons of this crisis and make investments in mapping their supply networks so that they do not operate blind when the next crisis strikes, these are the ultimate winners. Some of the major challenges faced by supply chains due to COVID-19 include the following [22, 23]:
Lack of visibility due to higher levels of SC network complexity
High uncertainty on both supply and demand end
Limited production flexibility
Limited financial flexibility
In several countries consumer surveys show a likelihood of greater spending on groceries and less spending on discretionary categories. According to McKinsey study on marketing and sales survey conducted in Italy, Spain, UK and US during March, 2020 reveals that except groceries (grown around 18%) other sectors like quick service restaurants, restaurants, footwear, apparel, jewelry, accessories, furnishing and appliances have recorded negative growth ranging from 50–85%. Among all sectors, restaurants are the worst affected.
Another important incident of 2011 Tsunami in Japan can also help the business organizations around the world to learn important lessons. After the 2011 earthquake and tsunami had devastated north-east in Japan it led to the application of a new methodology that was developed that enables a sophisticated way to understand the exposure to risk associated with unlikely events such as COVID-19 pandemic. The ability of the supply chain to recover from the disaster should be considered by the supplier as a performance factor of the supply chains.
McKinsey [22] has suggested the following three step framework for rapid recovery:
According to some of the major studies by McKinsey, Economist and others [22, 23, 24], the early starters of economy include health care including pharmaceuticals, medtech, diagnostics, hospital and home care services, telehealth/telemedicine, essential items, food and agriculture, FMCG, 3D printing, internet of things (IoT), AI/ML, robotics, smart systems, e-commerce industry. COVID-19 has put the medtech industry at center stage with unparalleled demand for diagnostic test PPE, ventilators, and critical medical supplies. McKinsey [22, 23] has built a detailed model of COVID-19 impact on medical procedures mainly for the United States on the Europe which is used to create a model for predicting the potential impact on medical device sales in consumables and implants. The models consider two broad scenarios for COVID-19 case growth V shape recovery and W shape recovery. In V shape recovery, it is estimated that the material procedures decline by around 70% in the second quarter and up to 45% in third quarter when compared to 2019. It is expected to see a rapid ramp up for the next three forth to catch up on delayed elective procedures. Whereas in W shaped recovery, procedures would decline by 69% and 45% in the second and third quarters respectively.
It will not be that easy for many organizations to have a detailed analytical understanding of demand variability at local and national level. However,
Develop a high-risk supply chain disruption-monitoring and response program for countries impacted by the virus and the potential supply chain exposure from Tier 1 and below.
Assign high-risk weighting to suppliers and sub-tiers from emerging and developing countries with less developed healthcare systems that are less prepared.
Conduct a contract review to understand any financial implications of not being able to deliver supplies to manufacturing locations and customers.
Special attention for balancing of supply and demand, building suitable safety stocks are essential for business continuity, particularly with the unpredictable volatility of supply chain functions.
Identify various opportunities at supply side and diversify suppliers to ensure manufacturing capacity and raw material availability.
Establish a robust risk management models to monitor and prepare for shortages in material, manufacturing capacity and work closely with supply chain stakeholders particularly with critical suppliers.
Implement and utilize enhanced risk management, including scenario planning to create preemptive action plans.
Review the New Product Introduction process and utilize design measures to discover or develop alternative sources and routes in order to diversify your value chains. At the same time, analyze cascading implications of changes in volumes, quality and markets.
The most common approach is to use the bill of materials and focus on key components.
Some of the major actions suggested by McKinsey for economy recovery [23] is given below.
Some of the actions suggested for recovery of medtech industry [22] include the following.
The company is required to fundamentally rethink the supply chain network and key suppliers as they were already facing pressure to localize in certain markets, after the crisis it will continue to be important for the companies to consider how to balance these pressures that can impact local supplies with potential desires for greater flexibility in capacity. These adaptations could include building more agile organizations, speeding time to market and aspiring to “absolute benchmarks” for product design and development and manufacturing efficiency.
Some of the lessons learned from fast food service organizations like KFC, McDonald etc. include the following which are based on digitalization:
These are the five specific capabilities that can have a dramatic impact on performance of the healthcare supply chain [26]:
Better segmentation of products, markets and customers.
Greater agility to reduce cost and increase flexibility.
Measurement and benchmarking.
Alignment with global standards.
Collaboration across the healthcare value chain.
Supply chain issues create opportunities for counterfeiters and gray market vendors threatening patient safety and cutting into revenues of legitimate companies. Supply chain security breaches are increasing by an average of 33% every year not only in the emerging markets such as China, India & Brazil but also in the developed world. Better supply chain processes are central to increasing patient safety. Therefore, it is recommended that adopting a common global data standard and upgraded grading supply chain processes could/counterfeiting in half returning up to $15 Billion to $30 Billion in revenue to legitimate companies to reinvest in further improvements to patient care.
Organizations can learn from the experience of laptop manufacturer in Indian who can accept an order and deliver a customized computers to a European customer in almost a week. Other organizations like pharmaceutical and medical equipment companies can adopt two broad approaches based on internal factors and external factors. Internal factors include – segmentation, agility, measurement while the external factors include- alignment & collaboration [27].
According to [25], the supply chains needs a stress test in terms of time to recover (TTR) and time to survive (TTS). TTR is the time it takes for a particular player/stakeholder (supplier, manufacturer, distributor, retailer etc.) in the supply chain to restore full functionality after disruption. TTS is the maximum duration that supply chain can match supply with demand after facility disruption. TTS also estimate each measure under different scenarios of business and Identify its ability to recover from the disaster. Organizations need to have a backup plan when TTR of a stakeholder or facility is greater than its TTS. This helps the organization in quantifying the cost of disruptions and prepare mitigation plans for the most critical parts of the supply chain [25].
At macro level, the economic recovery requires actions such as government stimulus, digitalization, advance technologies like 3D printing, up-skilling/multiskilling of workforce, restructuring of supply chains with better resilience and response, collaboration/alliances, facilitating innovation by start-ups, strengthening research collaboration between government, industry and academia is also very critical for faster recovery.
There is a strong relationship between world trade, GDP and supply chain investments around the world during last more than two centuries starting from 1800. As globalization has increased, the world’s supply chains have become substantially more interconnected. Moreover, as emerging market economies have steadily come to account for a greater proportion of global GDP, goods often have more stages to pass through before reaching the end consumer.
During last seven decades (starting from 1960s) the economic growth of the world is very significant and also seen many disruptions like Tsunamis, 911 Terrorist attacks, pandemics like COVID-19. Among all the COVID-19 crisis is more significant in terms of health and economy. COVID-19 has led to nearly 5% negative growth of world economy. From national lockdowns to closed airspace and borders, Covid-19 has resulted in unprecedented disruption to the mechanics of most economies, regardless of their size or stage of development. In particular, the erection of these barriers has placed a major strain on the world’s supply chains, including essential linkages relating to food and medicines. COVID-19 also created tension between major economies of the world and disrupted global supply chains significantly. Supply chain leaders face pressure to rethink traditional distribution and supplier models. For example, Amazon looks to strengthen its healthcare influence through the expansion of services in the medical supply chain, industry stakeholders are reconsidering traditional hospital-supplier relationships. Data, analytics and technology are playing an increasingly important role in supply chain strategy. A 2018 Global Healthcare Exchange survey [28] showed roughly 60 percent of respondents indicated data and analytics were the highest priority areas for improvement. These changes and trends have pushed the role of supply chain management into new territory. Now, supply chain leaders are positioned to help lead their organizations to higher levels of customer service with more efficient models [29, 30]. To ensure success amid this changing environment, business leaders including healthcare organizations should place an emphasis on technology, business practices and customer service.
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\n\nFor a complete overview of all publishing process steps and descriptions, go to How Open Access Publishing Works.
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\n\nIf you are interested in publishing your book with IntechOpen, please submit your book proposal by completing the Publishing Proposal Form.
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Marquis, Éric Guillaume and Carine Chivas-Joly",authors:[{id:"44307",title:"Dr",name:"Damien",middleName:"Michel",surname:"Marquis",slug:"damien-marquis",fullName:"Damien Marquis"},{id:"44317",title:"Prof.",name:"Carine",middleName:null,surname:"Chivas-Joly",slug:"carine-chivas-joly",fullName:"Carine Chivas-Joly"}]},{id:"52860",doi:"10.5772/65937",title:"Cerium Oxide Nanostructures and their Applications",slug:"cerium-oxide-nanostructures-and-their-applications",totalDownloads:5377,totalCrossrefCites:24,totalDimensionsCites:58,abstract:"Due to excellent physical and chemical properties, cerium oxide (ceria, CeO2) has attracted much attention in recent years. This chapter aimed at providing some basic and fundamental properties of ceria, the importance of oxygen vacancies in this material, nano‐size effects and various synthesis strategies to form diverse structural morphologies. Finally, some key applications of ceria‐based nanostructures are reviewed. We conclude this chapter by expressing personal perspective on the probable challenges and developments of the controllable synthesis of CeO2 nanomaterials for various applications.",book:{id:"5510",slug:"functionalized-nanomaterials",title:"Functionalized Nanomaterials",fullTitle:"Functionalized Nanomaterials"},signatures:"Adnan Younis, Dewei Chu and Sean Li",authors:[{id:"191574",title:"Dr.",name:"Adnan",middleName:null,surname:"Younis",slug:"adnan-younis",fullName:"Adnan Younis"}]}],mostDownloadedChaptersLast30Days:[{id:"38951",title:"Carbon Nanotube Transparent Electrode",slug:"carbon-nanotube-transparent-electrode",totalDownloads:3985,totalCrossrefCites:3,totalDimensionsCites:5,abstract:null,book:{id:"3077",slug:"syntheses-and-applications-of-carbon-nanotubes-and-their-composites",title:"Syntheses and Applications of Carbon Nanotubes and Their Composites",fullTitle:"Syntheses and Applications of Carbon Nanotubes and Their Composites"},signatures:"Jing Sun and Ranran Wang",authors:[{id:"153508",title:"Prof.",name:"Jing",middleName:null,surname:"Sun",slug:"jing-sun",fullName:"Jing Sun"},{id:"153596",title:"Ms.",name:"Ranran",middleName:null,surname:"Wang",slug:"ranran-wang",fullName:"Ranran Wang"}]},{id:"49413",title:"Electrodeposition of Nanostructure Materials",slug:"electrodeposition-of-nanostructure-materials",totalDownloads:3733,totalCrossrefCites:1,totalDimensionsCites:7,abstract:"We are conducting a multi-disciplinary research work that involves development of nanostructured thin films of semiconductors for different applications. Nanotechnology is widely considered to constitute the basis of the next technological revolution, following on from the first Industrial Revolution, which began around 1750 with the introduction of the steam engine and steelmaking. Nanotechnology is defined as the design, characterization, production, and application of materials, devices and systems by controlling shape and size of the nanoscale. The nanoscale itself is at present considered to cover the range from 1 to 100 nm. All samples prepared in thin film forms and the characterization revealed their nanostructure. The major exploitation of thin films has been in microelectronics, there are numerous and growing applications in communications, optical electronics, coatings of all kinds, and in energy generation. A great many sophisticated analytical instruments and techniques, largely developed to characterize thin films, have already become indispensable in virtually every scientific endeavor irrespective of discipline. Among all these techniques, electrodeposition is the most suitable technique for nanostructured thin films from aqueous solution served as samples under investigation. The electrodeposition of metallic layers from aqueous solution is based on the discharge of metal ions present in the electrolyte at a cathodic surface (the substrate or component.) The metal ions accept an electron from the electrically conducting material at the solid- electrolyte interface and then deposit as metal atoms onto the surface. The electrons necessary for this to occur are either supplied from an externally applied potential source or are surrendered by a reducing agent present in solution (electroless reduction). The metal ions themselves derive either from metal salts added to solution, or by the anodic dissolution of the so-called sacrificial anodes, made of the same metal that is to be deposited at the cathode.",book:{id:"4718",slug:"electroplating-of-nanostructures",title:"Electroplating of Nanostructures",fullTitle:"Electroplating of Nanostructures"},signatures:"Souad A. M. Al-Bat’hi",authors:[{id:"174793",title:"Dr.",name:"Mohamad",middleName:null,surname:"Souad",slug:"mohamad-souad",fullName:"Mohamad Souad"}]},{id:"54226",title:"Localized Surface Plasmon Resonance for Optical Fiber-Sensing Applications",slug:"localized-surface-plasmon-resonance-for-optical-fiber-sensing-applications",totalDownloads:2265,totalCrossrefCites:2,totalDimensionsCites:5,abstract:"It is well known that optical fiber sensors have attracted the attention of scientific community due to its intrinsic advantages, such as lightweight, small size, portability, remote sensing, immunity to electromagnetic interferences and the possibility of multiplexing several signals. This field has shown a dramatic growth thanks to the creation of sensitive thin films onto diverse optical fiber configurations. In this sense, a wide range of optical fiber devices have been successfully fabricated for monitoring biological, chemical, medical or physical parameters. In addition, the use of nanoparticles into the sensitive thin films has resulted in an enhancement in the response time, robustness or sensitivity in the optical devices, which is associated to the inherent properties of nanoparticles (high surface area ratio or porosity). Among all of them, the metallic nanoparticles are of great interest for sensing applications due to the presence of strong absorption bands in the visible and near-infrared regions, due to their localized surface plasmon resonances (LSPR). These optical resonances are due to the coupling of certain modes of the incident light to the collective oscillation of the conduction electrons of the metallic nanoparticles. The LSPR extinction bands are very useful for sensing applications as far as they can be affected by refractive index variations of the surrounding medium of the nanoparticles, and therefore, it is possible to create optical sensors with outstanding properties such as high sensitivity and optical self-reference. In this chapter, the attractive optical properties of metal nanostructures and their implementation into different optical fiber configuration for sensing or biosensing applications will be studied.",book:{id:"5721",slug:"nanoplasmonics-fundamentals-and-applications",title:"Nanoplasmonics",fullTitle:"Nanoplasmonics - Fundamentals and Applications"},signatures:"Pedro J. Rivero, Javier Goicoechea and Francisco J. Arregui",authors:[{id:"69816",title:"Dr.",name:"Javier",middleName:null,surname:"Goicoechea",slug:"javier-goicoechea",fullName:"Javier Goicoechea"},{id:"188796",title:"Dr.",name:"Pedro J.",middleName:null,surname:"Rivero",slug:"pedro-j.-rivero",fullName:"Pedro J. Rivero"},{id:"197277",title:"Dr.",name:"Francisco",middleName:null,surname:"Arregui",slug:"francisco-arregui",fullName:"Francisco Arregui"}]},{id:"25297",title:"Nanofabrication of Metal Oxide Patterns Using Self-Assembled Monolayers",slug:"nanofabrication-of-metal-oxide-patterns-using-self-assembled-monolayers",totalDownloads:3443,totalCrossrefCites:0,totalDimensionsCites:0,abstract:null,book:{id:"860",slug:"nanofabrication",title:"Nanofabrication",fullTitle:"Nanofabrication"},signatures:"Yoshitake Masuda",authors:[{id:"12385",title:"Dr.",name:"Yoshitake",middleName:null,surname:"Masuda",slug:"yoshitake-masuda",fullName:"Yoshitake Masuda"}]},{id:"77225",title:"Piezoelectricity and Its Applications",slug:"piezoelectricity-and-its-applications",totalDownloads:510,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"The piezoelectric effect is extensively encountered in nature and many synthetic materials. Piezoelectric materials are capable of transforming mechanical strain and vibration energy into electrical energy. This property allows opportunities for implementing renewable and sustainable energy through power harvesting and self-sustained smart sensing in buildings. As the most common construction material, plain cement paste lacks satisfactory piezoelectricity and is not efficient at harvesting the electrical energy from the ambient vibrations of a building system. In recent years, many techniques have been proposed and applied to improve the piezoelectric capacity of cement-based composite, namely admixture incorporation and physical. The successful application of piezoelectric materials for sustainable building development not only relies on understanding the mechanism of the piezoelectric properties of various building components, but also the latest developments and implementations in the building industry. Therefore, this review systematically illustrates research efforts to develop new construction materials with high piezoelectricity and energy storage capacity. In addition, this article discusses the latest techniques for utilizing the piezoelectric materials in energy harvesters, sensors and actuators for various building systems. With advanced methods for improving the cementations piezoelectricity and applying the material piezoelectricity for different building functions, more renewable and sustainable building systems are anticipated.",book:{id:"10511",slug:"multifunctional-ferroelectric-materials",title:"Multifunctional Ferroelectric Materials",fullTitle:"Multifunctional Ferroelectric Materials"},signatures:"B. Chandra Sekhar, B. Dhanalakshmi, B. Srinivasa Rao, S. Ramesh, K. Venkata Prasad, P.S.V. Subba Rao and B. Parvatheeswara Rao",authors:[{id:"335022",title:"Dr.",name:"B. Chandra",middleName:null,surname:"Sekhar",slug:"b.-chandra-sekhar",fullName:"B. Chandra Sekhar"},{id:"422021",title:"Dr.",name:"B.",middleName:null,surname:"Dhanalakshmi",slug:"b.-dhanalakshmi",fullName:"B. Dhanalakshmi"},{id:"422022",title:"Dr.",name:"B.Srinivasa",middleName:null,surname:"Rao",slug:"b.srinivasa-rao",fullName:"B.Srinivasa Rao"},{id:"422023",title:"Dr.",name:"S.",middleName:null,surname:"Ramesh",slug:"s.-ramesh",fullName:"S. Ramesh"},{id:"422024",title:"Dr.",name:"K.Venkata",middleName:null,surname:"Prasad",slug:"k.venkata-prasad",fullName:"K.Venkata Prasad"},{id:"422025",title:"Dr.",name:"P.S.V",middleName:null,surname:"Subba Rao",slug:"p.s.v-subba-rao",fullName:"P.S.V Subba Rao"},{id:"422026",title:"Dr.",name:"B.Parvatheeswara",middleName:null,surname:"Rao",slug:"b.parvatheeswara-rao",fullName:"B.Parvatheeswara Rao"}]}],onlineFirstChaptersFilter:{topicId:"1169",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"81438",title:"Research Progress of Ionic Thermoelectric Materials for Energy Harvesting",slug:"research-progress-of-ionic-thermoelectric-materials-for-energy-harvesting",totalDownloads:24,totalDimensionsCites:0,doi:"10.5772/intechopen.101771",abstract:"Thermoelectric material is a kind of functional material that can mutually convert heat energy and electric energy. It can convert low-grade heat energy (less than 130°C) into electric energy. Compared with traditional electronic thermoelectric materials, ionic thermoelectric materials have higher performance. The Seebeck coefficient can generate 2–3 orders of magnitude higher ionic thermoelectric potential than electronic thermoelectric materials, so it has good application prospects in small thermoelectric generators and solar power generation. According to the thermoelectric conversion mechanism, ionic thermoelectric materials can be divided into ionic thermoelectric materials based on the Soret effect and thermocouple effect. They are widely used in pyrogen batteries and ionic thermoelectric capacitors. The latest two types of ionic thermoelectric materials are in this article. The research progress is explained, and the problems and challenges of ionic thermoelectric materials and the future development direction are also put forward.",book:{id:"10037",title:"Thermoelectricity - Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10037.jpg"},signatures:"Jianwei Zhang, Ying Xiao, Bowei Lei, Gengyuan Liang and Wenshu Zhao"},{id:"77670",title:"Thermoelectric Elements with Negative Temperature Factor of Resistance",slug:"thermoelectric-elements-with-negative-temperature-factor-of-resistance",totalDownloads:72,totalDimensionsCites:0,doi:"10.5772/intechopen.98860",abstract:"The method of manufacturing of ceramic materials on the basis of ferrites of nickel and cobalt by synthesis and sintering in controllable regenerative atmosphere is presented. As the generator of regenerative atmosphere the method of conversion of carbonic gas is offered. Calculation of regenerative atmosphere for simultaneous sintering of ceramic ferrites of nickel and cobalt is carried out. It is offered, methods of the dilated nonequilibrium thermodynamics to view process of distribution of a charge and heat along a thermoelement branch. The model of a thermoelement taking into account various relaxation times of a charge and warmth is constructed.",book:{id:"10037",title:"Thermoelectricity - Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10037.jpg"},signatures:"Yuri Bokhan"},{id:"79236",title:"Processing Techniques with Heating Conditions for Multiferroic Systems of BiFeO3, BaTiO3, PbTiO3, CaTiO3 Thin Films",slug:"processing-techniques-with-heating-conditions-for-multiferroic-systems-of-bifeo3-batio3-pbtio3-catio",totalDownloads:96,totalDimensionsCites:0,doi:"10.5772/intechopen.101122",abstract:"In this chapter, we have report a list of synthesis methods (including both synthesis steps & heating conditions) used for thin film fabrication of perovskite ABO3 (BiFeO3, BaTiO3, PbTiO3 and CaTiO3) based multiferroics (in both single-phase and composite materials). The processing of high quality multiferroic thin film have some features like epitaxial strain, physical phenomenon at atomic-level, interfacial coupling parameters to enhance device performance. Since these multiferroic thin films have ME properties such as electrical (dielectric, magnetoelectric coefficient & MC) and magnetic (ferromagnetic, magnetic susceptibility etc.) are heat sensitive, i.e. ME response at low as well as higher temperature might to enhance the device performance respect with long range ordering. The magnetoelectric coupling between ferromagnetism and ferroelectricity in multiferroic becomes suitable in the application of spintronics, memory and logic devices, and microelectronic memory or piezoelectric devices. In comparison with bulk multiferroic, the fabrication of multiferroic thin film with different structural geometries on substrate has reducible clamping effect. A brief procedure for multiferroic thin film fabrication in terms of their thermal conditions (temperature for film processing and annealing for crystallization) are described. Each synthesis methods have its own characteristic phenomenon in terms of film thickness, defects formation, crack free film, density, chip size, easier steps and availability etc. been described. A brief study towards phase structure and ME coupling for each multiferroic system of BiFeO3, BaTiO3, PbTiO3 and CaTiO3 is shown.",book:{id:"10037",title:"Thermoelectricity - Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10037.jpg"},signatures:"Kuldeep Chand Verma and Manpreet Singh"},{id:"78034",title:"Quantum Physical Interpretation of Thermoelectric Properties of Ruthenate Pyrochlores",slug:"quantum-physical-interpretation-of-thermoelectric-properties-of-ruthenate-pyrochlores",totalDownloads:78,totalDimensionsCites:0,doi:"10.5772/intechopen.99260",abstract:"Lead- and lead-yttrium ruthenate pyrochlores were synthesized and investigated for Seebeck coefficients, electrical- and thermal conductivity. Compounds A2B2O6.5+z with 0 ≤ z < 0.5 were defect pyrochlores and p-type conductors. The thermoelectric data were analyzed using quantum physical models to identify scattering mechanisms underlying electrical (σ) and thermal conductivity (κ) and to understand the temperature dependence of the Seebeck effect (S). In the metal-like lead ruthenates with different Pb:Ru ratios, σ (T) and the electronic thermal conductivity κe (T) were governed by ‘electron impurity scattering’, the lattice thermal conductivity κL (T) by the 3-phonon resistive process (Umklapp scattering). In the lead-yttrium ruthenate solid solutions (Pb(2-x)YxRu2O(6.5±z)), a metal–insulator transition occurred at 0.2 moles of yttrium. On the metallic side (<0.2 moles Y) ‘electron impurity scattering’ prevailed. On the semiconductor/insulator side between x = 0.2 and x = 1.0 several mechanisms were equally likely. At x > 1.5 the Mott Variable Range Hopping mechanism was active. S (T) was discussed for Pb-Y-Ru pyrochlores in terms of the effect of minority carrier excitation at lower- and a broadening of the Fermi distribution at higher temperatures. The figures of merit of all of these pyrochlores were still small (≤7.3 × 10−3).",book:{id:"10037",title:"Thermoelectricity - Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10037.jpg"},signatures:"Sepideh Akhbarifar"},{id:"77635",title:"Optimization of Thermoelectric Properties Based on Rashba Spin Splitting",slug:"optimization-of-thermoelectric-properties-based-on-rashba-spin-splitting",totalDownloads:124,totalDimensionsCites:0,doi:"10.5772/intechopen.98788",abstract:"In recent years, the application of thermoelectricity has become more and more widespread. Thermoelectric materials provide a simple and environmentally friendly solution for the direct conversion of heat to electricity. The development of higher performance thermoelectric materials and their performance optimization have become more important. Generally, to improve the ZT value, electrical conductivity, Seebeck coefficient and thermal conductivity must be globally optimized as a whole object. However, due to the strong coupling among ZT parameters in many cases, it is very challenging to break the bottleneck of ZT optimization currently. Beyond the traditional optimization methods (such as inducing defects, varying temperature), the Rashba effect is expected to effectively increase the S2σ and decrease the κ, thus enhancing thermoelectric performance, which provides a new strategy to develop new-generation thermoelectric materials. Although the Rashba effect has great potential in enhancing thermoelectric performance, the underlying mechanism of Rashba-type thermoelectric materials needs further research. In addition, how to introduce Rashba spin splitting into current thermoelectric materials is also of great significance to the optimization of thermoelectricity.",book:{id:"10037",title:"Thermoelectricity - Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10037.jpg"},signatures:"Zhenzhen Qin"},{id:"75364",title:"Challenges in Improving Performance of Oxide Thermoelectrics Using Defect Engineering",slug:"challenges-in-improving-performance-of-oxide-thermoelectrics-using-defect-engineering",totalDownloads:214,totalDimensionsCites:0,doi:"10.5772/intechopen.96278",abstract:"Oxide thermoelectric materials are considered promising for high-temperature thermoelectric applications in terms of low cost, temperature stability, reversible reaction, and so on. Oxide materials have been intensively studied to suppress the defects and electronic charge carriers for many electronic device applications, but the studies with a high concentration of defects are limited. It desires to improve thermoelectric performance by enhancing its charge transport and lowering its lattice thermal conductivity. For this purpose, here, we modified the stoichiometry of cation and anion vacancies in two different systems to regulate the carrier concentration and explored their thermoelectric properties. Both cation and anion vacancies act as a donor of charge carriers and act as phonon scattering centers, decoupling the electrical conductivity and thermal conductivity.",book:{id:"10037",title:"Thermoelectricity - Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10037.jpg"},signatures:"Jamil Ur Rahman, Gul Rahman and Soonil Lee"}],onlineFirstChaptersTotal:6},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:98,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:287,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:10,numberOfPublishedChapters:103,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:10,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"7",title:"Biomedical Engineering",doi:"10.5772/intechopen.71985",issn:"2631-5343",scope:"Biomedical Engineering is one of the fastest-growing interdisciplinary branches of science and industry. The combination of electronics and computer science with biology and medicine has improved patient diagnosis, reduced rehabilitation time, and helped to facilitate a better quality of life. Nowadays, all medical imaging devices, medical instruments, or new laboratory techniques result from the cooperation of specialists in various fields. The series of Biomedical Engineering books covers such areas of knowledge as chemistry, physics, electronics, medicine, and biology. This series is intended for doctors, engineers, and scientists involved in biomedical engineering or those wanting to start working in this field.",coverUrl:"https://cdn.intechopen.com/series/covers/7.jpg",latestPublicationDate:"May 13th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:12,editor:{id:"50150",title:"Prof.",name:"Robert",middleName:null,surname:"Koprowski",slug:"robert-koprowski",fullName:"Robert Koprowski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYTYNQA4/Profile_Picture_1630478535317",biography:"Robert Koprowski, MD (1997), PhD (2003), Habilitation (2015), is an employee of the University of Silesia, Poland, Institute of Computer Science, Department of Biomedical Computer Systems. For 20 years, he has studied the analysis and processing of biomedical images, emphasizing the full automation of measurement for a large inter-individual variability of patients. Dr. Koprowski has authored more than a hundred research papers with dozens in impact factor (IF) journals and has authored or co-authored six books. Additionally, he is the author of several national and international patents in the field of biomedical devices and imaging. Since 2011, he has been a reviewer of grants and projects (including EU projects) in biomedical engineering.",institutionString:null,institution:{name:"University of Silesia",institutionURL:null,country:{name:"Poland"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"10",title:"Animal Physiology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/10.jpg",isOpenForSubmission:!0,editor:{id:"202192",title:"Dr.",name:"Catrin",middleName:null,surname:"Rutland",slug:"catrin-rutland",fullName:"Catrin Rutland",profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",biography:"Catrin Rutland is an Associate Professor of Anatomy and Developmental Genetics at the University of Nottingham, UK. She obtained a BSc from the University of Derby, England, a master’s degree from Technische Universität München, Germany, and a Ph.D. from the University of Nottingham. She undertook a post-doctoral research fellowship in the School of Medicine before accepting tenure in Veterinary Medicine and Science. Dr. Rutland also obtained an MMedSci (Medical Education) and a Postgraduate Certificate in Higher Education (PGCHE). She is the author of more than sixty peer-reviewed journal articles, twelve books/book chapters, and more than 100 research abstracts in cardiovascular biology and oncology. She is a board member of the European Association of Veterinary Anatomists, Fellow of the Anatomical Society, and Senior Fellow of the Higher Education Academy. Dr. Rutland has also written popular science books for the public. https://orcid.org/0000-0002-2009-4898. www.nottingham.ac.uk/vet/people/catrin.rutland",institutionString:null,institution:{name:"University of Nottingham",institutionURL:null,country:{name:"United Kingdom"}}},editorTwo:null,editorThree:null},{id:"11",title:"Cell Physiology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/11.jpg",isOpenForSubmission:!0,editor:{id:"133493",title:"Prof.",name:"Angel",middleName:null,surname:"Catala",slug:"angel-catala",fullName:"Angel Catala",profilePictureURL:"https://mts.intechopen.com/storage/users/133493/images/3091_n.jpg",biography:"Prof. Dr. Angel Catalá \r\nShort Biography Angel Catalá was born in Rodeo (San Juan, Argentina). He studied \r\nchemistry at the Universidad Nacional de La Plata, Argentina, where received aPh.D. degree in chemistry (Biological Branch) in 1965. From\r\n1964 to 1974, he worked as Assistant in Biochemistry at the School of MedicineUniversidad Nacional de La Plata, Argentina. From 1974 to 1976, he was a Fellowof the National Institutes of Health (NIH) at the University of Connecticut, Health Center, USA. From 1985 to 2004, he served as a Full Professor oBiochemistry at the Universidad Nacional de La Plata, Argentina. He is Member ofthe National Research Council (CONICET), Argentina, and Argentine Society foBiochemistry and Molecular Biology (SAIB). His laboratory has been interested for manyears in the lipid peroxidation of biological membranes from various tissues and different species. Professor Catalá has directed twelve doctoral theses, publishedover 100 papers in peer reviewed journals, several chapters in books andtwelve edited books. Angel Catalá received awards at the 40th InternationaConference Biochemistry of Lipids 1999: Dijon (France). W inner of the Bimbo PanAmerican Nutrition, Food Science and Technology Award 2006 and 2012, South AmericaHuman Nutrition, Professional Category. 2006 award in pharmacology, Bernardo\r\nHoussay, in recognition of his meritorious works of research. Angel Catalá belongto the Editorial Board of Journal of lipids, International Review of Biophysical ChemistryFrontiers in Membrane Physiology and Biophysics, World Journal oExperimental Medicine and Biochemistry Research International, W orld Journal oBiological Chemistry, Oxidative Medicine and Cellular Longevity, Diabetes and thePancreas, International Journal of Chronic Diseases & Therapy, International Journal oNutrition, Co-Editor of The Open Biology Journal.",institutionString:null,institution:{name:"National University of La Plata",institutionURL:null,country:{name:"Argentina"}}},editorTwo:null,editorThree:null},{id:"12",title:"Human Physiology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/12.jpg",isOpenForSubmission:!0,editor:{id:"195829",title:"Prof.",name:"Kunihiro",middleName:null,surname:"Sakuma",slug:"kunihiro-sakuma",fullName:"Kunihiro Sakuma",profilePictureURL:"https://mts.intechopen.com/storage/users/195829/images/system/195829.jpg",biography:"Professor Kunihiro Sakuma, Ph.D., currently works in the Institute for Liberal Arts at the Tokyo Institute of Technology. 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Radiotherapy and Nuclear Medicine Technology has always been my aspiration and my life. As years passed I accumulated a tremendous amount of skills and knowledge in Radiotherapy and Nuclear Medicine, Conventional Radiology, Radiation Protection, Bioinformatics Technology, PACS, Image processing, clinically and lecturing that will enable me to provide a valuable service to the community as a Researcher and Consultant in this field. My method of translating this into day to day in clinical practice is non-exhaustible and my habit of exchanging knowledge and expertise with others in those fields is the code and secret of success.",institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"313277",title:"Dr.",name:"Bartłomiej",middleName:null,surname:"Płaczek",slug:"bartlomiej-placzek",fullName:"Bartłomiej Płaczek",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/313277/images/system/313277.jpg",biography:"Bartłomiej Płaczek, MSc (2002), Ph.D. (2005), Habilitation (2016), is a professor at the University of Silesia, Institute of Computer Science, Poland, and an expert from the National Centre for Research and Development. His research interests include sensor networks, smart sensors, intelligent systems, and image processing with applications in healthcare and medicine. He is the author or co-author of more than seventy papers in peer-reviewed journals and conferences as well as the co-author of several books. He serves as a reviewer for many scientific journals, international conferences, and research foundations. Since 2010, Dr. Placzek has been a reviewer of grants and projects (including EU projects) in the field of information technologies.",institutionString:"University of Silesia",institution:{name:"University of Silesia",country:{name:"Poland"}}},{id:"35000",title:"Prof.",name:"Ulrich H.P",middleName:"H.P.",surname:"Fischer",slug:"ulrich-h.p-fischer",fullName:"Ulrich H.P Fischer",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/35000/images/3052_n.jpg",biography:"Academic and Professional Background\nUlrich H. P. has Diploma and PhD degrees in Physics from the Free University Berlin, Germany. He has been working on research positions in the Heinrich-Hertz-Institute in Germany. Several international research projects has been performed with European partners from France, Netherlands, Norway and the UK. He is currently Professor of Communications Systems at the Harz University of Applied Sciences, Germany.\n\nPublications and Publishing\nHe has edited one book, a special interest book about ‘Optoelectronic Packaging’ (VDE, Berlin, Germany), and has published over 100 papers and is owner of several international patents for WDM over POF key elements.\n\nKey Research and Consulting Interests\nUlrich’s research activity has always been related to Spectroscopy and Optical Communications Technology. Specific current interests include the validation of complex instruments, and the application of VR technology to the development and testing of measurement systems. He has been reviewer for several publications of the Optical Society of America\\'s including Photonics Technology Letters and Applied Optics.\n\nPersonal Interests\nThese include motor cycling in a very relaxed manner and performing martial arts.",institutionString:null,institution:{name:"Charité",country:{name:"Germany"}}},{id:"341622",title:"Ph.D.",name:"Eduardo",middleName:null,surname:"Rojas Alvarez",slug:"eduardo-rojas-alvarez",fullName:"Eduardo Rojas Alvarez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/341622/images/15892_n.jpg",biography:null,institutionString:null,institution:{name:"University of Cuenca",country:{name:"Ecuador"}}},{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/215610/images/system/215610.jpeg",biography:"Muhammad Sarfraz is a professor in the Department of Information Science, Kuwait University, Kuwait. His research interests include optimization, computer graphics, computer vision, image processing, machine learning, pattern recognition, soft computing, data science, and intelligent systems. Prof. Sarfraz has been a keynote/invited speaker at various platforms around the globe. He has advised/supervised more than 110 students for their MSc and Ph.D. theses. He has published more than 400 publications as books, journal articles, and conference papers. He has authored and/or edited around seventy books. Prof. Sarfraz is a member of various professional societies. He is a chair and member of international advisory committees and organizing committees of numerous international conferences. He is also an editor and editor in chief for various international journals.",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"32650",title:"Prof.",name:"Lukas",middleName:"Willem",surname:"Snyman",slug:"lukas-snyman",fullName:"Lukas Snyman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/32650/images/4136_n.jpg",biography:"Lukas Willem Snyman received his basic education at primary and high schools in South Africa, Eastern Cape. He enrolled at today's Nelson Metropolitan University and graduated from this university with a BSc in Physics and Mathematics, B.Sc Honors in Physics, MSc in Semiconductor Physics, and a Ph.D. in Semiconductor Physics in 1987. After his studies, he chose an academic career and devoted his energy to the teaching of physics to first, second, and third-year students. After positions as a lecturer at the University of Port Elizabeth, he accepted a position as Associate Professor at the University of Pretoria, South Africa.\r\n\r\nIn 1992, he motivates the concept of 'television and computer-based education” as means to reach large student numbers with only the best of teaching expertise and publishes an article on the concept in the SA Journal of Higher Education of 1993 (and later in 2003). The University of Pretoria subsequently approved a series of test projects on the concept with outreach to Mamelodi and Eerste Rust in 1993. In 1994, the University established a 'Unit for Telematic Education ' as a support section for multiple faculties at the University of Pretoria. In subsequent years, the concept of 'telematic education” subsequently becomes well established in academic circles in South Africa, grew in popularity, and is adopted by many universities and colleges throughout South Africa as a medium of enhancing education and training, as a method to reaching out to far out communities, and as a means to enhance study from the home environment.\r\n\r\nProfessor Snyman in subsequent years pursued research in semiconductor physics, semiconductor devices, microelectronics, and optoelectronics.\r\n\r\nIn 2000 he joined the TUT as a full professor. Here served for a period as head of the Department of Electronic Engineering. Here he makes contributions to solar energy development, microwave and optoelectronic device development, silicon photonics, as well as contributions to new mobile telecommunication systems and network planning in SA.\r\n\r\nCurrently, he teaches electronics and telecommunications at the TUT to audiences ranging from first-year students to Ph.D. level.\r\n\r\nFor his research in the field of 'Silicon Photonics” since 1990, he has published (as author and co-author) about thirty internationally reviewed articles in scientific journals, contributed to more than forty international conferences, about 25 South African provisional patents (as inventor and co-inventor), 8 PCT international patent applications until now. Of these, two USA patents applications, two European Patents, two Korean patents, and ten SA patents have been granted. A further 4 USA patents, 5 European patents, 3 Korean patents, 3 Chinese patents, and 3 Japanese patents are currently under consideration.\r\n\r\nRecently he has also published an extensive scholarly chapter in an internet open access book on 'Integrating Microphotonic Systems and MOEMS into standard Silicon CMOS Integrated circuitry”.\r\n\r\nFurthermore, Professor Snyman recently steered a new initiative at the TUT by introducing a 'Laboratory for Innovative Electronic Systems ' at the Department of Electrical Engineering. The model of this laboratory or center is to primarily combine outputs as achieved by high-level research with lower-level system development and entrepreneurship in a technical university environment. Students are allocated to projects at different levels with PhDs and Master students allocated to the generation of new knowledge and new technologies, while students at the diploma and Baccalaureus level are allocated to electronic systems development with a direct and a near application for application in industry or the commercial and public sectors in South Africa.\r\n\r\nProfessor Snyman received the WIRSAM Award of 1983 and the WIRSAM Award in 1985 in South Africa for best research papers by a young scientist at two international conferences on electron microscopy in South Africa. He subsequently received the SA Microelectronics Award for the best dissertation emanating from studies executed at a South African university in the field of Physics and Microelectronics in South Africa in 1987. In October of 2011, Professor Snyman received the prestigious Institutional Award for 'Innovator of the Year” for 2010 at the Tshwane University of Technology, South Africa. This award was based on the number of patents recognized and granted by local and international institutions as well as for his contributions concerning innovation at the TUT.",institutionString:null,institution:{name:"University of South Africa",country:{name:"South Africa"}}},{id:"317279",title:"Mr.",name:"Ali",middleName:"Usama",surname:"Syed",slug:"ali-syed",fullName:"Ali Syed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/317279/images/16024_n.png",biography:"A creative, talented, and innovative young professional who is dedicated, well organized, and capable research fellow with two years of experience in graduate-level research, published in engineering journals and book, with related expertise in Bio-robotics, equally passionate about the aesthetics of the mechanical and electronic system, obtained expertise in the use of MS Office, MATLAB, SolidWorks, LabVIEW, Proteus, Fusion 360, having a grasp on python, C++ and assembly language, possess proven ability in acquiring research grants, previous appointments with social and educational societies with experience in administration, current affiliations with IEEE and Web of Science, a confident presenter at conferences and teacher in classrooms, able to explain complex information to audiences of all levels.",institutionString:null,institution:{name:"Air University",country:{name:"Pakistan"}}},{id:"75526",title:"Ph.D.",name:"Zihni Onur",middleName:null,surname:"Uygun",slug:"zihni-onur-uygun",fullName:"Zihni Onur Uygun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/75526/images/12_n.jpg",biography:"My undergraduate education and my Master of Science educations at Ege University and at Çanakkale Onsekiz Mart University have given me a firm foundation in Biochemistry, Analytical Chemistry, Biosensors, Bioelectronics, Physical Chemistry and Medicine. After obtaining my degree as a MSc in analytical chemistry, I started working as a research assistant in Ege University Medical Faculty in 2014. In parallel, I enrolled to the MSc program at the Department of Medical Biochemistry at Ege University to gain deeper knowledge on medical and biochemical sciences as well as clinical chemistry in 2014. In my PhD I deeply researched on biosensors and bioelectronics and finished in 2020. Now I have eleven SCI-Expanded Index published papers, 6 international book chapters, referee assignments for different SCIE journals, one international patent pending, several international awards, projects and bursaries. In parallel to my research assistant position at Ege University Medical Faculty, Department of Medical Biochemistry, in April 2016, I also founded a Start-Up Company (Denosens Biotechnology LTD) by the support of The Scientific and Technological Research Council of Turkey. Currently, I am also working as a CEO in Denosens Biotechnology. The main purposes of the company, which carries out R&D as a research center, are to develop new generation biosensors and sensors for both point-of-care diagnostics; such as glucose, lactate, cholesterol and cancer biomarker detections. My specific experimental and instrumental skills are Biochemistry, Biosensor, Analytical Chemistry, Electrochemistry, Mobile phone based point-of-care diagnostic device, POCTs and Patient interface designs, HPLC, Tandem Mass Spectrometry, Spectrophotometry, ELISA.",institutionString:null,institution:{name:"Ege University",country:{name:"Turkey"}}},{id:"246502",title:"Dr.",name:"Jaya T.",middleName:"T",surname:"Varkey",slug:"jaya-t.-varkey",fullName:"Jaya T. Varkey",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246502/images/11160_n.jpg",biography:"Jaya T. Varkey, PhD, graduated with a degree in Chemistry from Cochin University of Science and Technology, Kerala, India. She obtained a PhD in Chemistry from the School of Chemical Sciences, Mahatma Gandhi University, Kerala, India, and completed a post-doctoral fellowship at the University of Minnesota, USA. She is a research guide at Mahatma Gandhi University and Associate Professor in Chemistry, St. Teresa’s College, Kochi, Kerala, India.\nDr. Varkey received a National Young Scientist award from the Indian Science Congress (1995), a UGC Research award (2016–2018), an Indian National Science Academy (INSA) Visiting Scientist award (2018–2019), and a Best Innovative Faculty award from the All India Association for Christian Higher Education (AIACHE) (2019). She Hashas received the Sr. Mary Cecil prize for best research paper three times. She was also awarded a start-up to develop a tea bag water filter. \nDr. Varkey has published two international books and twenty-seven international journal publications. She is an editorial board member for five international journals.",institutionString:"St. Teresa’s College",institution:null},{id:"250668",title:"Dr.",name:"Ali",middleName:null,surname:"Nabipour Chakoli",slug:"ali-nabipour-chakoli",fullName:"Ali Nabipour Chakoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/250668/images/system/250668.jpg",biography:"Academic Qualification:\r\n•\tPhD in Materials Physics and Chemistry, From: Sep. 2006, to: Sep. 2010, School of Materials Science and Engineering, Harbin Institute of Technology, Thesis: Structure and Shape Memory Effect of Functionalized MWCNTs/poly (L-lactide-co-ε-caprolactone) Nanocomposites. Supervisor: Prof. Wei Cai,\r\n•\tM.Sc in Applied Physics, From: 1996, to: 1998, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Determination of Boron in Micro alloy Steels with solid state nuclear track detectors by neutron induced auto radiography, Supervisors: Dr. M. Hosseini Ashrafi and Dr. A. Hosseini.\r\n•\tB.Sc. in Applied Physics, From: 1991, to: 1996, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Design of shielding for Am-Be neutron sources for In Vivo neutron activation analysis, Supervisor: Dr. M. Hosseini Ashrafi.\r\n\r\nResearch Experiences:\r\n1.\tNanomaterials, Carbon Nanotubes, Graphene: Synthesis, Functionalization and Characterization,\r\n2.\tMWCNTs/Polymer Composites: Fabrication and Characterization, \r\n3.\tShape Memory Polymers, Biodegradable Polymers, ORC, Collagen,\r\n4.\tMaterials Analysis and Characterizations: TEM, SEM, XPS, FT-IR, Raman, DSC, DMA, TGA, XRD, GPC, Fluoroscopy, \r\n5.\tInteraction of Radiation with Mater, Nuclear Safety and Security, NDT(RT),\r\n6.\tRadiation Detectors, Calibration (SSDL),\r\n7.\tCompleted IAEA e-learning Courses:\r\nNuclear Security (15 Modules),\r\nNuclear Safety:\r\nTSA 2: Regulatory Protection in Occupational Exposure,\r\nTips & Tricks: Radiation Protection in Radiography,\r\nSafety and Quality in Radiotherapy,\r\nCourse on Sealed Radioactive Sources,\r\nCourse on Fundamentals of Environmental Remediation,\r\nCourse on Planning for Environmental Remediation,\r\nKnowledge Management Orientation Course,\r\nFood Irradiation - Technology, Applications and Good Practices,\r\nEmployment:\r\nFrom 2010 to now: Academic staff, Nuclear Science and Technology Research Institute, Kargar Shomali, Tehran, Iran, P.O. Box: 14395-836.\r\nFrom 1997 to 2006: Expert of Materials Analysis and Characterization. Research Center of Agriculture and Medicine. Rajaeeshahr, Karaj, Iran, P. O. Box: 31585-498.",institutionString:"Atomic Energy Organization of Iran",institution:{name:"Atomic Energy Organization of Iran",country:{name:"Iran"}}},{id:"248279",title:"Dr.",name:"Monika",middleName:"Elzbieta",surname:"Machoy",slug:"monika-machoy",fullName:"Monika Machoy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248279/images/system/248279.jpeg",biography:"Monika Elżbieta Machoy, MD, graduated with distinction from the Faculty of Medicine and Dentistry at the Pomeranian Medical University in 2009, defended her PhD thesis with summa cum laude in 2016 and is currently employed as a researcher at the Department of Orthodontics of the Pomeranian Medical University. She expanded her professional knowledge during a one-year scholarship program at the Ernst Moritz Arndt University in Greifswald, Germany and during a three-year internship at the Technical University in Dresden, Germany. She has been a speaker at numerous orthodontic conferences, among others, American Association of Orthodontics, European Orthodontic Symposium and numerous conferences of the Polish Orthodontic Society. She conducts research focusing on the effect of orthodontic treatment on dental and periodontal tissues and the causes of pain in orthodontic patients.",institutionString:"Pomeranian Medical University",institution:{name:"Pomeranian Medical University",country:{name:"Poland"}}},{id:"252743",title:"Prof.",name:"Aswini",middleName:"Kumar",surname:"Kar",slug:"aswini-kar",fullName:"Aswini Kar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252743/images/10381_n.jpg",biography:"uploaded in cv",institutionString:null,institution:{name:"KIIT University",country:{name:"India"}}},{id:"204256",title:"Dr.",name:"Anil",middleName:"Kumar",surname:"Kumar Sahu",slug:"anil-kumar-sahu",fullName:"Anil Kumar Sahu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204256/images/14201_n.jpg",biography:"I have nearly 11 years of research and teaching experience. I have done my master degree from University Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur, Chhattisgarh India. I have published 16 review and research articles in international and national journals and published 4 chapters in IntechOpen, the world’s leading publisher of Open access books. I have presented many papers at national and international conferences. I have received research award from Indian Drug Manufacturers Association in year 2015. My research interest extends from novel lymphatic drug delivery systems, oral delivery system for herbal bioactive to formulation optimization.",institutionString:null,institution:{name:"Chhattisgarh Swami Vivekanand Technical University",country:{name:"India"}}},{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",biography:"An assistant professor at Department of Biomedical Computer Systems, at Institute of Computer Science, Silesian University in Katowice. Scientific interests: computer analysis and processing of images, biomedical images, databases and programming languages. He is an author and co-author of scientific publications covering analysis and processing of biomedical images and development of database systems.",institutionString:"University of Silesia",institution:null},{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",biography:"Dr. Hadi Mohammadi is a biomedical engineer with hands-on experience in the design and development of many engineering structures and medical devices through various projects that he has been involved in over the past twenty years. Dr. Mohammadi received his BSc. and MSc. degrees in Mechanical Engineering from Sharif University of Technology, Tehran, Iran, and his PhD. degree in Biomedical Engineering (biomaterials) from the University of Western Ontario. He was a postdoctoral trainee for almost four years at University of Calgary and Harvard Medical School. He is an industry innovator having created the technology to produce lifelike synthetic platforms that can be used for the simulation of almost all cardiovascular reconstructive surgeries. He’s been heavily involved in the design and development of cardiovascular devices and technology for the past 10 years. He is currently an Assistant Professor with the University of British Colombia, Canada.",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",country:{name:"Canada"}}},{id:"254463",title:"Prof.",name:"Haisheng",middleName:null,surname:"Yang",slug:"haisheng-yang",fullName:"Haisheng Yang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/254463/images/system/254463.jpeg",biography:"Haisheng Yang, Ph.D., Professor and Director of the Department of Biomedical Engineering, College of Life Science and Bioengineering, Beijing University of Technology. He received his Ph.D. degree in Mechanics/Biomechanics from Harbin Institute of Technology (jointly with University of California, Berkeley). Afterwards, he worked as a Postdoctoral Research Associate in the Purdue Musculoskeletal Biology and Mechanics Lab at the Department of Basic Medical Sciences, Purdue University, USA. He also conducted research in the Research Centre of Shriners Hospitals for Children-Canada at McGill University, Canada. Dr. Yang has over 10 years research experience in orthopaedic biomechanics and mechanobiology of bone adaptation and regeneration. He earned an award from Beijing Overseas Talents Aggregation program in 2017 and serves as Beijing Distinguished Professor.",institutionString:"Beijing University of Technology",institution:null},{id:"255757",title:"Dr.",name:"Igor",middleName:"Victorovich",surname:"Lakhno",slug:"igor-lakhno",fullName:"Igor Lakhno",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255757/images/system/255757.jpg",biography:"Lakhno Igor Victorovich was born in 1971 in Kharkiv (Ukraine). \nMD – 1994, Kharkiv National Medical Univesity.\nOb&Gyn; – 1997, master courses in Kharkiv Medical Academy of Postgraduate Education.\nPhD – 1999, Kharkiv National Medical Univesity.\nDSc – 2019, PL Shupik National Academy of Postgraduate Education \nLakhno Igor has been graduated from an international training courses on reproductive medicine and family planning held in Debrecen University (Hungary) in 1997. Since 1998 Lakhno Igor has worked as an associate professor of the department of obstetrics and gynecology of VN Karazin National University and an associate professor of the perinatology, obstetrics and gynecology department of Kharkiv Medical Academy of Postgraduate Education. Since June 2019 he’s a professor of the department of obstetrics and gynecology of VN Karazin National University and a professor of the perinatology, obstetrics and gynecology department of Kharkiv Medical Academy of Postgraduate Education . He’s an author of about 200 printed works and there are 17 of them in Scopus or Web of Science databases. Lakhno Igor is a rewiever of Journal of Obstetrics and Gynaecology (Taylor and Francis), Informatics in Medicine Unlocked (Elsevier), The Journal of Obstetrics and Gynecology Research (Wiley), Endocrine, Metabolic & Immune Disorders-Drug Targets (Bentham Open), The Open Biomedical Engineering Journal (Bentham Open), etc. He’s defended a dissertation for DSc degree \\'Pre-eclampsia: prediction, prevention and treatment”. Lakhno Igor has participated as a speaker in several international conferences and congresses (International Conference on Biological Oscillations April 10th-14th 2016, Lancaster, UK, The 9th conference of the European Study Group on Cardiovascular Oscillations). His main scientific interests: obstetrics, women’s health, fetal medicine, cardiovascular medicine.",institutionString:"V.N. Karazin Kharkiv National University",institution:{name:"Kharkiv Medical Academy of Postgraduate Education",country:{name:"Ukraine"}}},{id:"89721",title:"Dr.",name:"Mehmet",middleName:"Cuneyt",surname:"Ozmen",slug:"mehmet-ozmen",fullName:"Mehmet Ozmen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/89721/images/7289_n.jpg",biography:null,institutionString:null,institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"243698",title:"M.D.",name:"Xiaogang",middleName:null,surname:"Wang",slug:"xiaogang-wang",fullName:"Xiaogang Wang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243698/images/system/243698.png",biography:"Dr. Xiaogang Wang, a faculty member of Shanxi Eye Hospital specializing in the treatment of cataract and retinal disease and a tutor for postgraduate students of Shanxi Medical University, worked in the COOL Lab as an international visiting scholar under the supervision of Dr. David Huang and Yali Jia from October 2012 through November 2013. Dr. Wang earned an MD from Shanxi Medical University and a Ph.D. from Shanghai Jiao Tong University. Dr. Wang was awarded two research project grants focused on multimodal optical coherence tomography imaging and deep learning in cataract and retinal disease, from the National Natural Science Foundation of China. He has published around 30 peer-reviewed journal papers and four book chapters and co-edited one book.",institutionString:"Shanxi Eye Hospital",institution:{name:"Shanxi Eye Hospital",country:{name:"China"}}},{id:"242893",title:"Ph.D. Student",name:"Joaquim",middleName:null,surname:"De Moura",slug:"joaquim-de-moura",fullName:"Joaquim De Moura",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/242893/images/7133_n.jpg",biography:"Joaquim de Moura received his degree in Computer Engineering in 2014 from the University of A Coruña (Spain). In 2016, he received his M.Sc degree in Computer Engineering from the same university. He is currently pursuing his Ph.D degree in Computer Science in a collaborative project between ophthalmology centers in Galicia and the University of A Coruña. His research interests include computer vision, machine learning algorithms and analysis and medical imaging processing of various kinds.",institutionString:null,institution:{name:"University of A Coruña",country:{name:"Spain"}}},{id:"267434",title:"Dr.",name:"Rohit",middleName:null,surname:"Raja",slug:"rohit-raja",fullName:"Rohit Raja",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRZkkQAG/Profile_Picture_2022-05-09T12:55:18.jpg",biography:null,institutionString:null,institution:null},{id:"294334",title:"B.Sc.",name:"Marc",middleName:null,surname:"Bruggeman",slug:"marc-bruggeman",fullName:"Marc Bruggeman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/294334/images/8242_n.jpg",biography:"Chemical engineer graduate, with a passion for material science and specific interest in polymers - their near infinite applications intrigue me. \n\nI plan to continue my scientific career in the field of polymeric biomaterials as I am fascinated by intelligent, bioactive and biomimetic materials for use in both consumer and medical applications.",institutionString:null,institution:null},{id:"244950",title:"Dr.",name:"Salvatore",middleName:null,surname:"Di Lauro",slug:"salvatore-di-lauro",fullName:"Salvatore Di Lauro",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0030O00002bSF1HQAW/ProfilePicture%202021-12-20%2014%3A54%3A14.482",biography:"Name:\n\tSALVATORE DI LAURO\nAddress:\n\tHospital Clínico Universitario Valladolid\nAvda Ramón y Cajal 3\n47005, Valladolid\nSpain\nPhone number: \nFax\nE-mail:\n\t+34 983420000 ext 292\n+34 983420084\nsadilauro@live.it\nDate and place of Birth:\nID Number\nMedical Licence \nLanguages\t09-05-1985. Villaricca (Italy)\n\nY1281863H\n474707061\nItalian (native language)\nSpanish (read, written, spoken)\nEnglish (read, written, spoken)\nPortuguese (read, spoken)\nFrench (read)\n\t\t\nCurrent position (title and company)\tDate (Year)\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. Private practise.\t2017-today\n\n2019-today\n\t\n\t\nEducation (High school, university and postgraduate training > 3 months)\tDate (Year)\nDegree in Medicine and Surgery. University of Neaples 'Federico II”\nResident in Opthalmology. Hospital Clinico Universitario Valladolid\nMaster in Vitreo-Retina. IOBA. University of Valladolid\nFellow of the European Board of Ophthalmology. Paris\nMaster in Research in Ophthalmology. University of Valladolid\t2003-2009\n2012-2016\n2016-2017\n2016\n2012-2013\n\t\nEmployments (company and positions)\tDate (Year)\nResident in Ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl.\nFellow in Vitreo-Retina. IOBA. University of Valladolid\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. \n\t2012-2016\n2016-2017\n2017-today\n\n2019-Today\n\n\n\t\nClinical Research Experience (tasks and role)\tDate (Year)\nAssociated investigator\n\n' FIS PI20/00740: DESARROLLO DE UNA CALCULADORA DE RIESGO DE\nAPARICION DE RETINOPATIA DIABETICA BASADA EN TECNICAS DE IMAGEN MULTIMODAL EN PACIENTES DIABETICOS TIPO 1. Grant by: Ministerio de Ciencia e Innovacion \n\n' (BIO/VA23/14) Estudio clínico multicéntrico y prospectivo para validar dos\nbiomarcadores ubicados en los genes p53 y MDM2 en la predicción de los resultados funcionales de la cirugía del desprendimiento de retina regmatógeno. Grant by: Gerencia Regional de Salud de la Junta de Castilla y León.\n' Estudio multicéntrico, aleatorizado, con enmascaramiento doble, en 2 grupos\nparalelos y de 52 semanas de duración para comparar la eficacia, seguridad e inmunogenicidad de SOK583A1 respecto a Eylea® en pacientes con degeneración macular neovascular asociada a la edad' (CSOK583A12301; N.EUDRA: 2019-004838-41; FASE III). Grant by Hexal AG\n\n' Estudio de fase III, aleatorizado, doble ciego, con grupos paralelos, multicéntrico para comparar la eficacia y la seguridad de QL1205 frente a Lucentis® en pacientes con degeneración macular neovascular asociada a la edad. (EUDRACT: 2018-004486-13). Grant by Qilu Pharmaceutical Co\n\n' Estudio NEUTON: Ensayo clinico en fase IV para evaluar la eficacia de aflibercept en pacientes Naive con Edema MacUlar secundario a Oclusion de Vena CenTral de la Retina (OVCR) en regimen de tratamientO iNdividualizado Treat and Extend (TAE)”, (2014-000975-21). Grant by Fundacion Retinaplus\n\n' Evaluación de la seguridad y bioactividad de anillos de tensión capsular en conejo. Proyecto Procusens. Grant by AJL, S.A.\n\n'Estudio epidemiológico, prospectivo, multicéntrico y abierto\\npara valorar la frecuencia de la conjuntivitis adenovírica diagnosticada mediante el test AdenoPlus®\\nTest en pacientes enfermos de conjuntivitis aguda”\\n. National, multicenter study. Grant by: NICOX.\n\nEuropean multicentric trial: 'Evaluation of clinical outcomes following the use of Systane Hydration in patients with dry eye”. Study Phase 4. Grant by: Alcon Labs'\n\nVLPs Injection and Activation in a Rabbit Model of Uveal Melanoma. Grant by Aura Bioscience\n\nUpdating and characterization of a rabbit model of uveal melanoma. Grant by Aura Bioscience\n\nEnsayo clínico en fase IV para evaluar las variantes genéticas de la vía del VEGF como biomarcadores de eficacia del tratamiento con aflibercept en pacientes con degeneración macular asociada a la edad (DMAE) neovascular. Estudio BIOIMAGE. IMO-AFLI-2013-01\n\nEstudio In-Eye:Ensayo clínico en fase IV, abierto, aleatorizado, de 2 brazos,\nmulticçentrico y de 12 meses de duración, para evaluar la eficacia y seguridad de un régimen de PRN flexible individualizado de 'esperar y extender' versus un régimen PRN según criterios de estabilización mediante evaluaciones mensuales de inyecciones intravítreas de ranibizumab 0,5 mg en pacientes naive con neovascularización coriodea secunaria a la degeneración macular relacionada con la edad. CP: CRFB002AES03T\n\nTREND: Estudio Fase IIIb multicéntrico, randomizado, de 12 meses de\nseguimiento con evaluador de la agudeza visual enmascarado, para evaluar la eficacia y la seguridad de ranibizumab 0.5mg en un régimen de tratar y extender comparado con un régimen mensual, en pacientes con degeneración macular neovascular asociada a la edad. CP: CRFB002A2411 Código Eudra CT:\n2013-002626-23\n\n\n\nPublications\t\n\n2021\n\n\n\n\n2015\n\n\n\n\n2021\n\n\n\n\n\n2021\n\n\n\n\n2015\n\n\n\n\n2015\n\n\n2014\n\n\n\n\n2015-16\n\n\n\n2015\n\n\n2014\n\n\n2014\n\n\n\n\n2014\n\n\n\n\n\n\n\n2014\n\nJose Carlos Pastor; Jimena Rojas; Salvador Pastor-Idoate; Salvatore Di Lauro; Lucia Gonzalez-Buendia; Santiago Delgado-Tirado. Proliferative vitreoretinopathy: A new concept of disease pathogenesis and practical\nconsequences. Progress in Retinal and Eye Research. 51, pp. 125 - 155. 03/2016. DOI: 10.1016/j.preteyeres.2015.07.005\n\n\nLabrador-Velandia S; Alonso-Alonso ML; Di Lauro S; García-Gutierrez MT; Srivastava GK; Pastor JC; Fernandez-Bueno I. Mesenchymal stem cells provide paracrine neuroprotective resources that delay degeneration of co-cultured organotypic neuroretinal cultures.Experimental Eye Research. 185, 17/05/2019. DOI: 10.1016/j.exer.2019.05.011\n\nSalvatore Di Lauro; Maria Teresa Garcia Gutierrez; Ivan Fernandez Bueno. Quantification of pigment epithelium-derived factor (PEDF) in an ex vivo coculture of retinal pigment epithelium cells and neuroretina.\nJournal of Allbiosolution. 2019. ISSN 2605-3535\n\nSonia Labrador Velandia; Salvatore Di Lauro; Alonso-Alonso ML; Tabera Bartolomé S; Srivastava GK; Pastor JC; Fernandez-Bueno I. Biocompatibility of intravitreal injection of human mesenchymal stem cells in immunocompetent rabbits. Graefe's archive for clinical and experimental ophthalmology. 256 - 1, pp. 125 - 134. 01/2018. DOI: 10.1007/s00417-017-3842-3\n\n\nSalvatore Di Lauro, David Rodriguez-Crespo, Manuel J Gayoso, Maria T Garcia-Gutierrez, J Carlos Pastor, Girish K Srivastava, Ivan Fernandez-Bueno. A novel coculture model of porcine central neuroretina explants and retinal pigment epithelium cells. Molecular Vision. 2016 - 22, pp. 243 - 253. 01/2016.\n\nSalvatore Di Lauro. Classifications for Proliferative Vitreoretinopathy ({PVR}): An Analysis of Their Use in Publications over the Last 15 Years. Journal of Ophthalmology. 2016, pp. 1 - 6. 01/2016. DOI: 10.1155/2016/7807596\n\nSalvatore Di Lauro; Rosa Maria Coco; Rosa Maria Sanabria; Enrique Rodriguez de la Rua; Jose Carlos Pastor. Loss of Visual Acuity after Successful Surgery for Macula-On Rhegmatogenous Retinal Detachment in a Prospective Multicentre Study. Journal of Ophthalmology. 2015:821864, 2015. DOI: 10.1155/2015/821864\n\nIvan Fernandez-Bueno; Salvatore Di Lauro; Ivan Alvarez; Jose Carlos Lopez; Maria Teresa Garcia-Gutierrez; Itziar Fernandez; Eva Larra; Jose Carlos Pastor. Safety and Biocompatibility of a New High-Density Polyethylene-Based\nSpherical Integrated Porous Orbital Implant: An Experimental Study in Rabbits. Journal of Ophthalmology. 2015:904096, 2015. DOI: 10.1155/2015/904096\n\nPastor JC; Pastor-Idoate S; Rodríguez-Hernandez I; Rojas J; Fernandez I; Gonzalez-Buendia L; Di Lauro S; Gonzalez-Sarmiento R. Genetics of PVR and RD. Ophthalmologica. 232 - Suppl 1, pp. 28 - 29. 2014\n\nRodriguez-Crespo D; Di Lauro S; Singh AK; Garcia-Gutierrez MT; Garrosa M; Pastor JC; Fernandez-Bueno I; Srivastava GK. Triple-layered mixed co-culture model of RPE cells with neuroretina for evaluating the neuroprotective effects of adipose-MSCs. Cell Tissue Res. 358 - 3, pp. 705 - 716. 2014.\nDOI: 10.1007/s00441-014-1987-5\n\nCarlo De Werra; Salvatore Condurro; Salvatore Tramontano; Mario Perone; Ivana Donzelli; Salvatore Di Lauro; Massimo Di Giuseppe; Rosa Di Micco; Annalisa Pascariello; Antonio Pastore; Giorgio Diamantis; Giuseppe Galloro. Hydatid disease of the liver: thirty years of surgical experience.Chirurgia italiana. 59 - 5, pp. 611 - 636.\n(Italia): 2007. ISSN 0009-4773\n\nChapters in books\n\t\n' Salvador Pastor Idoate; Salvatore Di Lauro; Jose Carlos Pastor Jimeno. PVR: Pathogenesis, Histopathology and Classification. Proliferative Vitreoretinopathy with Small Gauge Vitrectomy. Springer, 2018. ISBN 978-3-319-78445-8\nDOI: 10.1007/978-3-319-78446-5_2. \n\n' Salvatore Di Lauro; Maria Isabel Lopez Galvez. Quistes vítreos en una mujer joven. Problemas diagnósticos en patología retinocoroidea. Sociedad Española de Retina-Vitreo. 2018.\n\n' Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor Jimeno. iOCT in PVR management. OCT Applications in Opthalmology. pp. 1 - 8. INTECH, 2018. DOI: 10.5772/intechopen.78774.\n\n' Rosa Coco Martin; Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor. amponadores, manipuladores y tinciones en la cirugía del traumatismo ocular.Trauma Ocular. Ponencia de la SEO 2018..\n\n' LOPEZ GALVEZ; DI LAURO; CRESPO. OCT angiografia y complicaciones retinianas de la diabetes. PONENCIA SEO 2021, CAPITULO 20. (España): 2021.\n\n' Múltiples desprendimientos neurosensoriales bilaterales en paciente joven. Enfermedades Degenerativas De Retina Y Coroides. SERV 04/2016. \n' González-Buendía L; Di Lauro S; Pastor-Idoate S; Pastor Jimeno JC. Vitreorretinopatía proliferante (VRP) e inflamación: LA INFLAMACIÓN in «INMUNOMODULADORES Y ANTIINFLAMATORIOS: MÁS ALLÁ DE LOS CORTICOIDES. RELACION DE PONENCIAS DE LA SOCIEDAD ESPAÑOLA DE OFTALMOLOGIA. 10/2014.",institutionString:null,institution:null},{id:"265335",title:"Mr.",name:"Stefan",middleName:"Radnev",surname:"Stefanov",slug:"stefan-stefanov",fullName:"Stefan Stefanov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/265335/images/7562_n.jpg",biography:null,institutionString:null,institution:null},{id:"318905",title:"Prof.",name:"Elvis",middleName:"Kwason",surname:"Tiburu",slug:"elvis-tiburu",fullName:"Elvis Tiburu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Ghana",country:{name:"Ghana"}}},{id:"336193",title:"Dr.",name:"Abdullah",middleName:null,surname:"Alamoudi",slug:"abdullah-alamoudi",fullName:"Abdullah Alamoudi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"318657",title:"MSc.",name:"Isabell",middleName:null,surname:"Steuding",slug:"isabell-steuding",fullName:"Isabell Steuding",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Harz University of Applied Sciences",country:{name:"Germany"}}},{id:"318656",title:"BSc.",name:"Peter",middleName:null,surname:"Kußmann",slug:"peter-kussmann",fullName:"Peter Kußmann",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Harz University of Applied Sciences",country:{name:"Germany"}}},{id:"338222",title:"Mrs.",name:"María José",middleName:null,surname:"Lucía Mudas",slug:"maria-jose-lucia-mudas",fullName:"María José Lucía Mudas",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Carlos III University of Madrid",country:{name:"Spain"}}},{id:"147824",title:"Mr.",name:"Pablo",middleName:null,surname:"Revuelta Sanz",slug:"pablo-revuelta-sanz",fullName:"Pablo Revuelta Sanz",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Carlos III University of Madrid",country:{name:"Spain"}}}]}},subseries:{item:{id:"15",type:"subseries",title:"Chemical Biology",keywords:"Phenolic Compounds, Essential Oils, Modification of Biomolecules, Glycobiology, Combinatorial Chemistry, Therapeutic peptides, Enzyme Inhibitors",scope:"Chemical biology spans the fields of chemistry and biology involving the application of biological and chemical molecules and techniques. In recent years, the application of chemistry to biological molecules has gained significant interest in medicinal and pharmacological studies. This topic will be devoted to understanding the interplay between biomolecules and chemical compounds, their structure and function, and their potential applications in related fields. Being a part of the biochemistry discipline, the ideas and concepts that have emerged from Chemical Biology have affected other related areas. This topic will closely deal with all emerging trends in this discipline.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11411,editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",slug:"sukru-beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",biography:"Dr. Şükrü Beydemir obtained a BSc in Chemistry in 1995 from Yüzüncü Yıl University, MSc in Biochemistry in 1998, and PhD in Biochemistry in 2002 from Atatürk University, Turkey. He performed post-doctoral studies at Max-Planck Institute, Germany, and University of Florence, Italy in addition to making several scientific visits abroad. He currently works as a Full Professor of Biochemistry in the Faculty of Pharmacy, Anadolu University, Turkey. Dr. Beydemir has published over a hundred scientific papers spanning protein biochemistry, enzymology and medicinal chemistry, reviews, book chapters and presented several conferences to scientists worldwide. He has received numerous publication awards from various international scientific councils. He serves in the Editorial Board of several international journals. Dr. Beydemir is also Rector of Bilecik Şeyh Edebali University, Turkey.",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",slug:"deniz-ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",biography:"Dr. Deniz Ekinci obtained a BSc in Chemistry in 2004, MSc in Biochemistry in 2006, and PhD in Biochemistry in 2009 from Atatürk University, Turkey. 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