\\n\\n
These books synthesize perspectives of renowned scientists from the world’s most prestigious institutions - from Fukushima Renewable Energy Institute in Japan to Stanford University in the United States, including Columbia University (US), University of Sidney (AU), University of Miami (USA), Cardiff University (UK), and many others.
\\n\\nThis collaboration embodied the true essence of Open Access by simplifying the approach to OA publishing for Academic editors and authors who contributed their research and allowed the new research to be made available free and open to anyone anywhere in the world.
\\n\\nTo celebrate the 50 books published, we have gathered them at one location - just one click away, so that you can easily browse the subjects of your interest, download the content directly, share it or read online.
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IntechOpen and Knowledge Unlatched formed a partnership to support researchers working in engineering sciences by enabling an easier approach to publishing Open Access content. Using the Knowledge Unlatched crowdfunding model to raise the publishing costs through libraries around the world, Open Access Publishing Fee (OAPF) was not required from the authors.
\n\nInitially, the partnership supported engineering research, but it soon grew to include physical and life sciences, attracting more researchers to the advantages of Open Access publishing.
\n\n\n\nThese books synthesize perspectives of renowned scientists from the world’s most prestigious institutions - from Fukushima Renewable Energy Institute in Japan to Stanford University in the United States, including Columbia University (US), University of Sidney (AU), University of Miami (USA), Cardiff University (UK), and many others.
\n\nThis collaboration embodied the true essence of Open Access by simplifying the approach to OA publishing for Academic editors and authors who contributed their research and allowed the new research to be made available free and open to anyone anywhere in the world.
\n\nTo celebrate the 50 books published, we have gathered them at one location - just one click away, so that you can easily browse the subjects of your interest, download the content directly, share it or read online.
\n\n\n\n\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"491",leadTitle:null,fullTitle:"Photodiodes - World Activities in 2011",title:"Photodiodes",subtitle:"World Activities in 2011",reviewType:"peer-reviewed",abstract:"Photodiodes or photodetectors are in one boat with our human race. Efforts of people in related fields are contained in this book. 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Sheregii",authors:[{id:"102655",title:"Prof.",name:"Eugen",middleName:null,surname:"Sheregii",fullName:"Eugen Sheregii",slug:"eugen-sheregii"}]},{id:"36191",title:"Effective Reaction Monitoring of Intermediates by ATR-IR Spectroscopy Utilizing Fibre Optic Probes",slug:"effective-reaction-monitoring-of-intermediates-by-atr-ir-spectroscopy-utilizing-fibre-optic-probes",signatures:"Daniel Lumpi and Christian Braunshier",authors:[{id:"109019",title:"Dr.",name:"Christian",middleName:null,surname:"Braunshier",fullName:"Christian Braunshier",slug:"christian-braunshier"},{id:"111798",title:"MSc.",name:"Daniel",middleName:null,surname:"Lumpi",fullName:"Daniel Lumpi",slug:"daniel-lumpi"}]}]}],publishedBooks:[{type:"book",id:"2121",title:"Recent Advances in Immunology to Target Cancer, Inflammation and Infections",subtitle:null,isOpenForSubmission:!1,hash:"fad86ff21f0275dfabc2a53ad2ece71e",slug:"recent-advances-in-immunology-to-target-cancer-inflammation-and-infections",bookSignature:"Jagat R. 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Kanwar",coverURL:"https://cdn.intechopen.com/books/images_new/2121.jpg",editedByType:"Edited by",editors:[{id:"40068",title:"Prof.",name:"Jagat",surname:"Kanwar",slug:"jagat-kanwar",fullName:"Jagat Kanwar"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},onlineFirst:{chapter:{type:"chapter",id:"81829",title:"Down to Earth?: A Crisis of the Environmental Crisis",doi:"10.5772/intechopen.104595",slug:"down-to-earth-a-crisis-of-the-environmental-crisis",body:'A necessity animates the argument in this essay: to expand the horizon of our thinking about earth beyond the opposition between Ptolemean (geocentric) and Copernican (heliocentric) worldviews. The Copernican worldview undergirds modern science and technology in approaches to the environmental crisis today. By contrast, the Ptolemean worldview is relegated to outdated beliefs. Yet the both run a version of centrism, a claim that there always is a center or a number of them. Opposing Ptolemy and Copernicus too strongly takes any other (call them “a-centric”) approaches to earth off the table. These tacitly suppressed approaches can promise more in how one goes about environmental crisis today.
The argument is also responding to a much more obvious but much harder to face necessity: The environmental crisis is political and human in nature; as such, it cannot be fully addressed—let alone understood—by technology. Instead, a critical rethinking of the fundamental assumptions about politics and about humanity in approaching earth becomes due. The essay contributes to such rethinking by asking how thinking earth as “environment” preempts one from thinking earth1 Attempting to manage the crisis is always only the second step. The logically first step is in having committed to the terms in which one thinks of the crisis. One has to rethink the first step before getting too far into second.
Facing the contemporary “environmental crisis,” one therefore needs “to step back” both in time and in the conceptual scope, in order to revisit the notion of environment as defining and possibly also blindfolding one’s approach to the crisis. This essay commits such a stepping back to rethink the relationships between earth and environment. By necessity to become clear below, that evokes “old” bodies of text and thought, not only from the last century, when environmentalism was first taking shape, but also from the late antiquity, from the long durée of the Western thought. The working assumption is that a simple passage of time does not automatically render “old” irrelevant, but rather that placing a modern issue into a framework of an “older” tradition of thought yields a double new result. It invites “to step back” in thinking through a modern issue and also to rethink the pertinence of the “old” corpora of thought in a new light.
To provide an in-advance outline of the argument-structure and result of this essay: The analysis first turns to Edmund Husserl’s (d. 1938) deductive-analytical mereology (a theory of whole as always more than its parts) of earth as a simple bodiless whole, from which all bodies split off. The essay further compares Husserl’s mereology with Augustine with structurally (but not thematically) similar mereology of “mind” in Augustine (d. 430 C.E.), for whom mind is an equally simple whole without parts. That in turn allows to juxtapose both approaches to the the nineteenth to twentieth centuries mereologies of organic and complex bodily wholes, from which modern notions of environment and environmentalism stem. That delineates the origin and the limit of organicist mereologies and of environmentalism having stemmed from them. This framework of analysis allows to show that environmentalist crisis is not only a crisis of preserving environment but also and more foundationally a crisis spurred by environment as a notion purporting to regulate human attitude toward the earth.
My argument arises in rethinking Edmund Husserl’s 1934 work about earth2 as a way to address limitations of the notion of environment as the constitutive notion for any discussion of “environmental crisis.” After a preliminary exposition of such limitations, I will first of all show how, in thinking the earth, Husserl committed a more radical move than either environmental localism3 or environmental cosmopolitanism (or globalism) can afford. Husserl was offering a more demanding and, in his view, more precise notion of the earth than any locality-driven nationalist environmentalists did, as they sported the specter of “blood and soil.” (I take the most extreme version of this kind of political thought, which also manifested itself in the magnanimous figure of “the Soviet Land” and in a miniature of “the little motherland,” each one was to love.) Husserl was not a localist. Nor was his notion of the earth a cosmopolitan one: The cosmopolites’ specter of the “citizen of the world” would only negate and thus still depend upon (even if only negatively) on the locality-driven politics of “blood and soil.” Effectively leaving both the locality-oriented and cosmopolitical versions of environmentalism behind, Husserl offers what I interpret as a holistic approach to earth—a mereology of the earth, which both localism and cosmopolitanism fail to account for properly.
After outlining Husserl’s mereology of the earth, I will second of all introduce its structural (rather than thematic) parallel, Augustine mereology of the
A constitutive and guiding notion in all discussions of “environmental crisis” is that of “environment.”
According to Oxford English Dictionary, etymologically “environment” suggests an “action of surrounding something.” The German synonyms for “environment”—“
The notion of environment is thus unavoidably centrist. This remains unchanged, no matter whether one subscribes to Ptolemean views, which are considered by some outdated; or to Copernican views, which are considered by others misleading in their reduction of humans to just objects of science. Do humans on the earth mark the center of the universe (the word “universe” designates no more than an extended version of the “environment”) around which the sun and stars are rotating? Alternatively, is the earth only one of the many planets? Is there one privileged center of the world (which is also “ours”) or are there many centers and thus no Center with the capital “C”? Either answer must begin from a version of centrism. There simply is no environment without at least one—but potentially also several—centers. Centrism and environmentalism are inseparable one from another.
The notion, of “environment,” is thus too geocentric and too anthropocentric to not obfuscate the discussion of the “environmental crisis,” which it seemingly purports to be leading. My argument below responds to that obfuscation. Is that possible, and if so, how to avoid such a centrism? In search for an answer, I first turn to the geo-thought of Edmund Husserl.
Looking for a logically necessary foundation (“source,”
However, Husserl’s is not the only mereology, in which the whole consists of neither parts nor of organs; Augustine view of the
Husserl departs from an understanding of the Earth as a body in either Ptolemean or Copernican sense and arrives to a mereological understanding of Earth “as a whole which is not a body,” from which, however, all bodies—planets, stones, cars but also visceral living bodies, like “my own” living body emerge through a process of separation. Highlights of Husserl’s argument are as follows. (1) Apodictically (but not necessarily empirically) on the way to earth and people in space, there first must be an initial absolute earth-body (either an ellipsis or a flat plateau), which neither moves nor rests; this would be a base-earth in relation to which the movement and rest of all other bodies become determined in the first place. (2) On such a base-earth, there is and must be a visceral, living Ego, which, like the initial (Ptolemean) base-earth, is neither moving nor resting, thereby allowing for the Copernican earth-planet to move and to rest. The visceral ego allows to transition from the (1) to the earth-planet as a relatively moving and relatively resting body among other bodies. That means that the visceral living Ego takes place of the base-earth in (2): the visceral Ego neither moves nor rests, giving a foundation for movement and rest of all bodies. (3) This living visceral Ego logically
Husserl builds this argument in response to what for him are unsurpassable “difficulties in establishing Earth as body.”10 However, as shaped as they are by the notion of environment, the discussions of the environmental crisis do not account for these difficulties, thereby, as Husserl helps see, missing the very earth these discussions purport to preserve. Yet, making this missing of the earth clear and loud might invite rethinking the terms of the “environmental crisis” in the first place. As this interpretation of Husserl highlights, these difficulties in establishing Earth as body apply to both Copernican and Ptolemean notions of the earth, thus revealing the common ground behind the two worldviews, a ground pertaining to the very notion of environment, however conceived. Whether the earth is thought of as a Copernican body (a planet among others) or as a Ptolemean body (an absolute center and an absolute neither moving nor resting ground for determining movement and rest), the “difficulties” Husserl lays bare remains the same: It is only possible to establish earth as body when and if earth is a mereological premise, foundation or ground (logical, physical and humanitarian alike) on which and only on which a body, indeed any and every body, can be ever thought or experienced.
To understand these “difficulties,” a more detailed exposition of Husserl’s 1934 argument is required. In the development of his argument, Husserl has four notions of earth: (1) a neither moving nor resting ground/base of experience of all moving and resting bodies; this is an outlook, which “I” gets through transferences to other Egos; this for Husserl holds for Copernican and Ptolemean and all other possible world-outlooks alike; (2) a moving and resting body (a planet among other planets); (3) the Ego-viscera [
Moving through these four senses of earth, Husserl arrives to a practical application of his mereology: If earth is not a body, there is and there can be only one earth12 and only one humanity: On whichever planet you (the visceral ego) go, you cannot arrive to another earth as such a whole or such a totality which is not a body.
The result of his argument is especially important in the context of polemics between local and national environmentalists on the one hand and the global environmentalists on the other: Both parties reduce the pieces of earth (Germany, France, continents) or even the whole planet Earth to a body, and this precludes the discussion of how to preserve earth by reaching its proper scope: How to think the only earth and the only humanity in the first place.
How then to evaluate Husserl’s mereology, both in its own terms, that is, as a mereology, and in terms of its application for the discussion of the environmental crisis? The second part of the question cannot be addressed without a due diligence with the first part. How then to place, that is to say, how to find proper limits to Husserl’s mereology of the bodiless earth. As already noted, his is not a mereology of an organic whole, for his earth is not a body, and thus is not an organism either. The closest to Husserl’s mereology of the earth can therefore be found in Augustin’s mereology of the mind. As we will momentarily see for Augustin mind is a whole without parts, which therefore entails a bodiless whole, as well.
Augustine
This mereology comes by way of polemics Augustine stages against Cicero.14 For Cicero, he argues, at stake is a virtue of prudence. A prudent one is to differentiate three kinds of phantasms one experiences from one’s intellectually clear cognition. The phantasms about the
Based on this concern with the prudent person, Augustine creates a time structure. Phantasms of the
Augustine result is a mereology of the mind which is a whole—in his case the who—who does not encounter oneself as a part of oneself, but only remembers oneself as a whole, that is to say as the present without parts.
What Husserl’s earth and Augustine mind have in common is a presence (Earth or Human/Divine mind) which/who is not defined as anything specific. For Husserl, it was the Earth which is not a body, from which all bodies are stemming. For Augustine, it was the mind remembering its own presence before the mind recalls, anticipates, perceives and/or contemplates things and matters.16 Mind is first of all memory and humanity is first of all earth; the two thinkers conclude respectively and almost in structural unison with each other. For both, there is a whole, a presence, which has no parts and from which all parts stem.
The differences between the two mereologies are too obvious to enumerate, yet one is particularly important: Husserl locates thinking in the visceral ego, while Augustine does not afford for the mind (which would be the best candidate for that) any bodily status whatsoever beyond what transpires from the memory of the present.
To understand the limits of these two mereologies is to relate them to what might be revealing about their common theological root. Other derivations from that same root can be instructive for understanding a particular direction Augustine mereology took and Husserl’s mereology followed. That common root will become clearer through juxtaposing the two mereologies with that of Philo of Alexandria in his philosophical reading of the G-d of the Septuagint.
If both Husserl and Augustine offer mereologies of bodiless wholes without organs or parts, an interpretative move of Philo of Alexandria in his understanding of relationships between the Septuagint’s G-d and the world (
At this juncture, the key is a polemical background, against which Philo’ creates a notion (and a neologism):
The world “subsists” under G-d, even if G-d is not a part of the world, Philo’s innovation further suggests to his Latin adherents. With Marcus Victorinus (fourth century C.E.), Latin theology mirrors Philo’s invention of
In this context, Husserl’s “earth” and Augustine “mind” present themselves as versions of Philo’s polemical mereology of huparxis.19 Augustine argues against reducing
The masters and students of rhetoric in Palestinian Rabbinical schools did not consider polemical contexts extraneous to the results of polemics. This general stance of any school of rhetoric found a particular configuration in a mereology of the Divine law the Palestinian rabbinical schools of rhetoric displayed in their extant archives, known today as the Palestinian Talmud or Jerusalem Talmud.20 What pertains to the context of this essay is that the Palestinian’s schools developed a mereology of the past as mereology of the divine law. Looking at their mereology sheds a new light on the mereology of
The Palestinian schools concern with a necessity and impossibility to testify for the divine law of the past. Such testifying, testimony or testament come in two forms: as an exemplary act (
The conflict of the impossibility and necessity to recall the law of the past is a version of mereology. The past is a whole that has no parts (in this case no fully specified laws/rules of procedure); and the recitations stemming from that past are (to use Husserl’s language) separations from the law of the past (just as the planets and other bodies were separations from the bodiless earth.) The paradoxy is that the characters in the Palestinian rabbinical schools of rhetoric in reciting the law make it present and thereby loosen or weaken its power, the power of the law of the past. This is why the characters in the Palestinian Talmud are often concerned with “what are we to testify to” or “what are we to establish” as the divine law (lit “what are we making stand” [
What does that mean by way of differing versions of mereologies considered heretofore? The Palestinian schools display a mereology of the past, which celebrates uncertainty of one’s standing between the impossible and the necessary, rather than committing to the would be false certainty about parts and parcels of the law of the obligation. Whereas this law comes from the past as a whole with no parts thereto, citing and detailing this law threatens its very power. Standing between Scilla of necessity and Haribdah of impossibility, the Rabbis, however, do not refuse to testify. They instead suspend testimony, thereby humiliating their own power of citation. They thereby suspend both the impossibility and the possibility to testify to the Law.
By comparison with Augustine memory of the present, the rabbis and students in the schools prefer the memory of the mereological past of the law over the recollection of the law in the present. That also means they prefer the memory of the law of the past to a recollection of that law in the form of definitive rules. Yet, facing the necessity of such recollection, they suspend such recollection/citation by committing to no final formulation of the law but only to a provisionally accepted number of recollections/citations. A community living by mutual obligations with G-d lives in suspension of any given recollection about the past of these obligations. Back to Augustine, instead of certainty of the memory of the present, this community lives by the uncertainty of the memory of the past. That celebrates a programmatic uncertainty as an authentic condition versus any certainty that Augustine offers in his “memory of the present.”
What that means, however, is that the mereologies of the bodiless whole without parts in Husserl and Augustine alike find a contrasting parallel in the rabbinic Palestinian mereology of the divine law. If the former strive for a certainty in the foundations of human life in a such a bodiless whole without parts, the Palestinian rabbis in their continuation of Philo’s mereology of
To conclude, Husserl’s mereology of the bodiless earth induces reservations about approaching the earth as environment. In its either localist or globalist versions, the notion of environment not only reduces the earth to a body, but also either begins with or stays within the anthropo- and geo-centric element. Husserl gestures toward a way to overcome such centrism: to approach earth as more than a body, that is, as not a body. His mereology of the bodiless earth, however, is as promising as it is also limited by his commitment (shared with Augustin) to finding a
Then what? Ascribing science the sole or even predominant responsibility for creating and resolving the “environmental crisis” needs a radical rethinking in view of the competing mereologies outlined above. For, they collectively put both earth and humanity back into consideration, while letting the Copernican science do what it does best, to work with the bodies. That also means keeping Copernican science apart from what is not a body, that is to say from the humanity and the earth.
The above analysis affords a conclusion that environmentalist thinking needs a sustained critique of its over-commitment to science, including the scientific view of wholes as organisms. Beyond and in addition to organicist holism of the bodies, a mereology of bodiless wholes without parts, in the competing versions thereof outlined above, needs to be brought forth and to claim its role in the understanding of what we do not understand when we lock ourselves into thinking about nature in terms of “environmental crisis” today.
Preparation of this article for publication was in part supported by Gordon and Gretchen Gross Professorship in Jewish Thought, University at Buffalo, SUNY. I thank Edouard Nadtochii and Elad Lapidot for many conversations and exchanges that contributed to shaping this argument.
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The immunoglobulin repertoire is provided by the process of somatic germ line recombination, which is the only controlled alteration of the genomic DNA after meiosis. It takes place in mammalian B lymphocyte (B cells) precursors in the bone marrow. The genome germ line sequence of undeveloped B cells is organized in gene segments and compromise V (variable), D (diversity), and J (joining) gene segments constituting the variable domain of the heavy chain and only V and J genes for building up the variable domain of the light chain. The rearrangement of the variable region follows a strict order. The following processes that participate in the generation of antibody diversity were summarized—allelic, combinational, and junctional diversity, pairing of IgH and IgL, and receptor editing—which all together produce the primary antigen repertoire (pre-antigen stimulation). When a B cell encounters a foreign antigen, affinity maturation and class switch are induced. 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The resulting secondary immunoglobulin repertoire reveals in humans at least 1011 specificities for different antigens.",book:{id:"5784",slug:"antibody-engineering",title:"Antibody Engineering",fullTitle:"Antibody Engineering"},signatures:"Oliver Backhaus",authors:[{id:"177685",title:"M.Sc.",name:"Oliver",middleName:null,surname:"Backhaus",slug:"oliver-backhaus",fullName:"Oliver Backhaus"}]},{id:"21711",title:"Screening of Bacterial Recombinants: Strategies and Preventing False Positives",slug:"screening-of-bacterial-recombinants-strategies-and-preventing-false-positives",totalDownloads:28415,totalCrossrefCites:1,totalDimensionsCites:5,abstract:null,book:{id:"375",slug:"molecular-cloning-selected-applications-in-medicine-and-biology",title:"Molecular Cloning",fullTitle:"Molecular Cloning - Selected Applications in Medicine and Biology"},signatures:"Sriram Padmanabhan, Sampali Banerjee and Naganath Mandi",authors:[{id:"46458",title:"Dr.",name:"Sriram",middleName:null,surname:"Padmanabhan",slug:"sriram-padmanabhan",fullName:"Sriram Padmanabhan"},{id:"136523",title:"Prof.",name:"Sampali",middleName:null,surname:"Banerjee",slug:"sampali-banerjee",fullName:"Sampali Banerjee"},{id:"136524",title:"Prof.",name:"Naganath",middleName:null,surname:"Mandi",slug:"naganath-mandi",fullName:"Naganath Mandi"}]},{id:"38236",title:"Extrinsic and Intrinsic Apoptosis Signal Pathway Review",slug:"extrinsic-and-intrinsic-apoptosis-signal-pathway-review",totalDownloads:11166,totalCrossrefCites:41,totalDimensionsCites:79,abstract:null,book:{id:"3141",slug:"apoptosis-and-medicine",title:"Apoptosis and Medicine",fullTitle:"Apoptosis and Medicine"},signatures:"Zhao Hongmei",authors:[{id:"146795",title:"Dr.",name:"Zhao",middleName:null,surname:"Hongmei",slug:"zhao-hongmei",fullName:"Zhao Hongmei"}]},{id:"19294",title:"Lagging Strand Synthesis and Genomic Stability",slug:"lagging-strand-synthesis-and-genomic-stability",totalDownloads:3352,totalCrossrefCites:0,totalDimensionsCites:2,abstract:null,book:{id:"346",slug:"dna-repair-on-the-pathways-to-fixing-dna-damage-and-errors",title:"DNA Repair",fullTitle:"DNA Repair - On the Pathways to Fixing DNA Damage and Errors"},signatures:"Tuan Anh Nguyen, Chul-Hwan Lee and Yeon-Soo Seo",authors:[{id:"45828",title:"Dr.",name:"Yeon-Soo",middleName:null,surname:"Seo",slug:"yeon-soo-seo",fullName:"Yeon-Soo Seo"},{id:"46800",title:"Ph.D.",name:"Tuan Anh",middleName:null,surname:"Nguyen",slug:"tuan-anh-nguyen",fullName:"Tuan Anh Nguyen"},{id:"57602",title:"Dr.",name:"Chul-Hwan",middleName:null,surname:"Lee",slug:"chul-hwan-lee",fullName:"Chul-Hwan Lee"}]},{id:"57802",title:"Control of Ribosomal RNA Transcription by Nutrients",slug:"control-of-ribosomal-rna-transcription-by-nutrients",totalDownloads:1609,totalCrossrefCites:3,totalDimensionsCites:6,abstract:"The ribosome is a unique machine for protein synthesis in organisms. The construction of ribosomes is exceedingly complex and consumes the majority of the cell materials and energy. The materials for ribosome production are supplied by nutrients. Therefore, the production of ribosomes is restricted by environmental nutrients, and cells need mechanisms to control ribosome production in order to reconcile demands for cell activities with available resources. Transcription of ribosomal RNA is an essential step in ribosome biogenesis. It strongly affects the total amount of ribosome production, and thus rapidly growing cells have an elevated level of ribosomal RNA transcription. Ribosomal RNA transcription is controlled by many mechanisms, including the efficiency of preinitiation complex formation for RNA polymerase I (Pol I) and epigenetic marks in ribosomal RNA genes. These are affected by cell cycle progression, signal transduction pathways, cell-damaging stresses, nutrients such as glucose, and the metabolites. Recent studies also suggest that the epigenetic marks, acetylation and methylation, may be not only controlled by nutrients but also function as reservoirs for biological resources in chromatin. Further studies would provide information about the mechanisms cells use to adjust production of cellular components to available resources and clues for developing novel anti-cancer treatments.",book:{id:"7204",slug:"gene-expression-and-regulation-in-mammalian-cells-transcription-toward-the-establishment-of-novel-therapeutics",title:"Gene Expression and Regulation in Mammalian Cells",fullTitle:"Gene Expression and Regulation in Mammalian Cells - Transcription Toward the Establishment of Novel Therapeutics"},signatures:"Yuji Tanaka and Makoto Tsuneoka",authors:[{id:"219040",title:"Prof.",name:"Makoto",middleName:null,surname:"Tsuneoka",slug:"makoto-tsuneoka",fullName:"Makoto Tsuneoka"},{id:"219221",title:"Dr.",name:"Yuji",middleName:null,surname:"Tanaka",slug:"yuji-tanaka",fullName:"Yuji Tanaka"}]}],onlineFirstChaptersFilter:{topicId:"400",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:0,limit:8,total:null},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:98,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:287,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:10,numberOfPublishedChapters:103,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:10,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"10",title:"Physiology",doi:"10.5772/intechopen.72796",issn:"2631-8261",scope:"Modern physiology requires a comprehensive understanding of the integration of tissues and organs throughout the mammalian body, including the cooperation between structure and function at the cellular and molecular levels governed by gene and protein expression. While a daunting task, learning is facilitated by identifying common and effective signaling pathways mediated by a variety of factors employed by nature to preserve and sustain homeostatic life. \r\nAs a leading example, the cellular interaction between intracellular concentration of Ca+2 increases, and changes in plasma membrane potential is integral for coordinating blood flow, governing the exocytosis of neurotransmitters, and modulating gene expression and cell effector secretory functions. 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From\r\n1964 to 1974, he worked as Assistant in Biochemistry at the School of MedicineUniversidad Nacional de La Plata, Argentina. From 1974 to 1976, he was a Fellowof the National Institutes of Health (NIH) at the University of Connecticut, Health Center, USA. From 1985 to 2004, he served as a Full Professor oBiochemistry at the Universidad Nacional de La Plata, Argentina. He is Member ofthe National Research Council (CONICET), Argentina, and Argentine Society foBiochemistry and Molecular Biology (SAIB). His laboratory has been interested for manyears in the lipid peroxidation of biological membranes from various tissues and different species. Professor Catalá has directed twelve doctoral theses, publishedover 100 papers in peer reviewed journals, several chapters in books andtwelve edited books. Angel Catalá received awards at the 40th InternationaConference Biochemistry of Lipids 1999: Dijon (France). W inner of the Bimbo PanAmerican Nutrition, Food Science and Technology Award 2006 and 2012, South AmericaHuman Nutrition, Professional Category. 2006 award in pharmacology, Bernardo\r\nHoussay, in recognition of his meritorious works of research. 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Additionally, to understand how to maintain and improve physical function in older adults, to conduct studies about the mechanism of sarcopenia and determine when possible interventions are needed.",institutionString:null,institution:{name:"Ritsumeikan University",institutionURL:null,country:{name:"Japan"}}}},{id:"13",title:"Plant Physiology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/13.jpg",isOpenForSubmission:!0,annualVolume:11409,editor:{id:"332229",title:"Prof.",name:"Jen-Tsung",middleName:null,surname:"Chen",slug:"jen-tsung-chen",fullName:"Jen-Tsung Chen",profilePictureURL:"https://mts.intechopen.com/storage/users/332229/images/system/332229.png",biography:"Dr. Jen-Tsung Chen is currently a professor at the National University of Kaohsiung, Taiwan. He teaches cell biology, genomics, proteomics, medicinal plant biotechnology, and plant tissue culture. Dr. Chen\\'s research interests include bioactive compounds, chromatography techniques, in vitro culture, medicinal plants, phytochemicals, and plant biotechnology. He has published more than ninety scientific papers and serves as an editorial board member for Plant Methods, Biomolecules, and International Journal of Molecular Sciences.",institutionString:"National University of Kaohsiung",institution:{name:"National University of Kaohsiung",institutionURL:null,country:{name:"Taiwan"}}},editorTwo:null,editorThree:null}]},overviewPageOFChapters:{paginationCount:17,paginationItems:[{id:"81751",title:"NanoBioSensors: From Electrochemical Sensors Improvement to Theranostic Applications",doi:"10.5772/intechopen.102552",signatures:"Anielle C.A. Silva, Eliete A. Alvin, Lais S. de Jesus, Caio C.L. de França, Marílya P.G. da Silva, Samaysa L. Lins, Diógenes Meneses, Marcela R. Lemes, Rhanoica O. Guerra, Marcos V. da Silva, Carlo J.F. de Oliveira, Virmondes Rodrigues Junior, Renata M. 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Since 2011, he has been a reviewer of grants and projects (including EU projects) in biomedical engineering.",institutionString:null,institution:{name:"University of Silesia",institutionURL:null,country:{name:"Poland"}}}]},{type:"book",id:"7218",title:"OCT",subtitle:"Applications in Ophthalmology",coverURL:"https://cdn.intechopen.com/books/images_new/7218.jpg",slug:"oct-applications-in-ophthalmology",publishedDate:"September 19th 2018",editedByType:"Edited by",bookSignature:"Michele Lanza",hash:"e3a3430cdfd6999caccac933e4613885",volumeInSeries:2,fullTitle:"OCT - Applications in Ophthalmology",editors:[{id:"240088",title:"Prof.",name:"Michele",middleName:null,surname:"Lanza",slug:"michele-lanza",fullName:"Michele Lanza",profilePictureURL:"https://mts.intechopen.com/storage/users/240088/images/system/240088.png",biography:"Michele Lanza is Associate Professor of Ophthalmology at Università della Campania, Luigi Vanvitelli, Napoli, Italy. His fields of interest are anterior segment disease, keratoconus, glaucoma, corneal dystrophies, and cataracts. His research topics include\nintraocular lens power calculation, eye modification induced by refractive surgery, glaucoma progression, and validation of new diagnostic devices in ophthalmology. \nHe has published more than 100 papers in international and Italian scientific journals, more than 60 in journals with impact factors, and chapters in international and Italian books. He has also edited two international books and authored more than 150 communications or posters for the most important international and Italian ophthalmology conferences.",institutionString:'University of Campania "Luigi Vanvitelli"',institution:{name:'University of Campania "Luigi Vanvitelli"',institutionURL:null,country:{name:"Italy"}}}]},{type:"book",id:"7560",title:"Non-Invasive Diagnostic Methods",subtitle:"Image Processing",coverURL:"https://cdn.intechopen.com/books/images_new/7560.jpg",slug:"non-invasive-diagnostic-methods-image-processing",publishedDate:"December 19th 2018",editedByType:"Edited by",bookSignature:"Mariusz Marzec and Robert Koprowski",hash:"d92fd8cf5a90a47f2b8a310837a5600e",volumeInSeries:3,fullTitle:"Non-Invasive Diagnostic Methods - Image Processing",editors:[{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",biography:"An assistant professor at Department of Biomedical Computer Systems, at Institute of Computer Science, Silesian University in Katowice. 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